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2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
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L1000
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
progabide 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
gabamimetic agents
2278
62666-20-0
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
progabide
halogabide
gabrene
gabren
GABA agonist; structure
Molecular weight: 334.78
Formula: C17H16ClFN2O2
CLOGP: 2.90
LIPINSKI: 0
HAC: 4
HDO: 2
TPSA: 75.68
ALOGS: -4.68
ROTB: 6
Drug dosage:
None
ADMET properties:
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Property
Value
Reference
BA (Bioavailability)
60 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
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Approvals:
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Date
Agency
Company
Orphan
Jan. 1, 1985
YEAR INTRODUCED
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
N03AG05
NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Fatty acid derivatives
MeSH PA
D018726
Anti-Dyskinesia Agents
MeSH PA
D000927
Anticonvulsants
MeSH PA
D000928
Antidepressive Agents
MeSH PA
D000978
Antiparkinson Agents
MeSH PA
D002491
Central Nervous System Agents
MeSH PA
D018682
GABA Agents
MeSH PA
D018755
GABA Agonists
MeSH PA
D018377
Neurotransmitter Agents
MeSH PA
D011619
Psychotropic Drugs
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
12.28
acidic
pKa2
13.0
acidic
pKa3
3.38
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
GABA-A receptor alpha-1/beta-2/gamma-2
Ion channel
P14867
P18507
P47870
GBRA1_HUMAN
GBRG2_HUMAN
GBRB2_HUMAN
Ki
4.40
WOMBAT-PK
GABA-A receptor; anion channel
Ion channel
O00591
O14764
P14867
P18505
P18507
P28472
P31644
P34903
P47869
P47870
P48169
P78334
Q16445
Q8N1C3
Q99928
Q9UN88
GBRP_HUMAN
GBRD_HUMAN
GBRA1_HUMAN
GBRB1_HUMAN
GBRG2_HUMAN
GBRB3_HUMAN
GBRA5_HUMAN
GBRA3_HUMAN
GBRA2_HUMAN
GBRB2_HUMAN
GBRA4_HUMAN
GBRE_HUMAN
GBRA6_HUMAN
GBRG1_HUMAN
GBRG3_HUMAN
GBRT_HUMAN
Ki
4.40
CHEMBL
GABA-A receptor; anion channel
Ion channel
GBRP_RAT
GBRB1_RAT
GBRD_RAT
GBRG2_RAT
GBRA5_RAT
GBRA3_RAT
GBRG1_RAT
GBRA2_RAT
GBRA4_RAT
GBRG3_RAT
GBRA6_RAT
GBRA1_RAT
GBRB3_RAT
GBRB2_RAT
Q91ZM7_RAT
GBRE_RAT
Ki
4.85
CHEMBL
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External reference:
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ID
Source
005334
NDDF
34568
RXNORM
38C836J57Z
UNII
44115
PUBCHEM_CID
4656
INN_ID
C0072076
UMLSCUI
C017985
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:135422
CHEBI
CHEMBL287631
ChEMBL_ID
D05621
KEGG_DRUG
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Pharmaceutical products:
None
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progabide