dithranol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	226	1143-38-0

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

anthralin
chrysodermol
dithranol
cigthranol

An anthracene derivative that disrupts MITOCHONDRIA function and structure and is used for the treatment of DERMATOSES, especially PSORIASIS. It may cause FOLLICULITIS.

Molecular weight: 226.23
Formula: C14H10O3
CLOGP: 4.03
LIPINSKI: 0
HAC: 3
HDO: 2
TPSA: 57.53
ALOGS: -3.09
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D05AC01	DERMATOLOGICALS ANTIPSORIATICS ANTIPSORIATICS FOR TOPICAL USE Antracen derivatives
ATC	D05AC51	DERMATOLOGICALS ANTIPSORIATICS ANTIPSORIATICS FOR TOPICAL USE Antracen derivatives
MeSH PA	D003879	Dermatologic Agents
CHEBI has role	CHEBI:50748	antipsoriatic drug

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Psoriasis	off-label use	9014002	DOID:8893
Alopecia areata	off-label use	68225006	DOID:986

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.42	acidic
pKa2	11.19	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Arachidonate 12-lipoxygenase, 12R-type	Enzyme	O75342	LX12B_HUMAN					WOMBAT-PK
NAD-dependent protein deacylase sirtuin-5, mitochondrial	Enzyme	Q9NXA8	SIR5_HUMAN		IC50	7		CHEMBL
Serine protease hepsin	Enzyme	P05981	HEPS_HUMAN		IC50	6.64		CHEMBL
5-lipoxygenase	Enzyme		Q9BEG3_BOVIN		IC50	4.43		CHEMBL
Trypsin	Enzyme		TRYP_PIG		IC50	5.90		CHEMBL

External reference:

ID	Source
4018598	VUID
N0000146914	NUI
D00233	KEGG_DRUG
873	RXNORM
C0003166	UMLSCUI
CHEBI:37510	CHEBI
CHEMBL46469	ChEMBL_ID
DB11157	DRUGBANK_ID
2202	PUBCHEM_CID
24	MMSL
4206	MMSL
387293003	SNOMEDCT_US
53800008	SNOMEDCT_US
D000875	MESH_DESCRIPTOR_UI
83	INN_ID
4018598	VANDF
U8CJK0JH5M	UNII
001984	NDDF

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
DRITHO-CREME HP	HUMAN PRESCRIPTION DRUG LABEL	1	11086-037	CREAM	1 g	TOPICAL	unapproved drug other	7 sections
ZITHRANOL-RR	HUMAN PRESCRIPTION DRUG LABEL	1	42783-101	cream	0.01 g	TOPICAL	unapproved drug other	12 sections
Zithranol	HUMAN PRESCRIPTION DRUG LABEL	1	42783-111	SHAMPOO	1 g	TOPICAL	unapproved drug other	12 sections