prenylamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2261 | 390-64-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A drug formerly used in the treatment of angina pectoris but superseded by less hazardous drugs. Prenylamine depletes myocardial catecholamine stores and has some calcium channel blocking activity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1406)
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.12 | g | O |
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C01DX02 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY VASODILATORS USED IN CARDIAC DISEASES Other vasodilators used in cardiac diseases |
| ATC | C01DX52 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY VASODILATORS USED IN CARDIAC DISEASES Other vasodilators used in cardiac diseases |
| MeSH PA | D018663 | Adrenergic Agents |
| MeSH PA | D002121 | Calcium Channel Blockers |
| MeSH PA | D000077264 | Calcium-Regulating Hormones and Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D049990 | Membrane Transport Modulators |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D014665 | Vasodilator Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.32 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sodium channel alpha subunits; brain (Types I, II, III) | Ion channel | IC50 | 6.52 | CHEMBL | |||||
| Voltage-gated L-type calcium channel | Ion channel | Kd | 6.68 | CHEMBL | |||||
| Calmodulin | Cytosolic other | Kd | 6.30 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D02167 | KEGG_DRUG |
| 69-43-2 | SECONDARY_CAS_RN |
| C0033059 | UMLSCUI |
| CHEBI:8397 | CHEBI |
| CHEMBL24072 | ChEMBL_ID |
| DB04825 | DRUGBANK_ID |
| D011299 | MESH_DESCRIPTOR_UI |
| C053347 | MESH_SUPPLEMENTAL_RECORD_UI |
| 9801 | PUBCHEM_CID |
| 1196 | INN_ID |
| K2OH82Z000 | UNII |
| 34407 | RXNORM |
| 004026 | NDDF |
| 004027 | NDDF |
| 387288001 | SNOMEDCT_US |
| 51908007 | SNOMEDCT_US |
Pharmaceutical products:
None