pregnenolone succinate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| steroids not used as glucocorticosteroids | 2256 | 4598-67-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues. Pregnenolone is the precursor to GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS.
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 0.03 mg/mL | Bocci G, Oprea TI, Benet LZ |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
| CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.41 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Corticosteroid-binding globulin | Secreted | Ki | 5.23 | CHEMBL | |||||
| Sex hormone-binding globulin | Secreted | Kd | 7.15 | CHEMBL | |||||
| Glucose-6-phosphate 1-dehydrogenase | Enzyme | IC50 | 4.09 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D00143 | KEGG_DRUG |
| 4032600 | VANDF |
| CHEBI:16581 | CHEBI |
| PLO | PDB_CHEM_ID |
| CHEMBL2105373 | ChEMBL_ID |
| DB02789 | DRUGBANK_ID |
| 114052 | RXNORM |
| NOCODE | MMSL |
| 004993 | NDDF |
| 004994 | NDDF |
| 47350002 | SNOMEDCT_US |
| C0771291 | UMLSCUI |
| C0373704 | UMLSCUI |
| CHEMBL253363 | ChEMBL_ID |
| 10070529 | PUBCHEM_CID |
| 4178 | INN_ID |
| 145-13-1 | SECONDARY_CAS_RN |
| 8955 | PUBCHEM_CID |
| D011284 | MESH_DESCRIPTOR_UI |
| 2376 | IUPHAR_LIGAND_ID |
| 6LN4W6JJK6 | UNII |
| 73R90F7MQ8 | UNII |
Pharmaceutical products:
None