pregnenolone succinate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
steroids not used as glucocorticosteroids 2256 4598-67-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pregnenolone succinate
A 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues. Pregnenolone is the precursor to GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS.
  • Molecular weight: 416.56
  • Formula: C25H36O5
  • CLOGP: 4.74
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 80.67
  • ALOGS: -4.98
  • ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.41 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sex hormone-binding globulin Secreted Kd 7.15 CHEMBL
Glucose-6-phosphate 1-dehydrogenase Enzyme IC50 4.09 CHEMBL
Corticosteroid-binding globulin Secreted Ki 5.23 CHEMBL

External reference:

IDSource
D00143 KEGG_DRUG
6LN4W6JJK6 UNII
4178 INN_ID
145-13-1 SECONDARY_CAS_RN
004994 NDDF
CHEMBL253363 ChEMBL_ID
10070529 PUBCHEM_CID
D011284 MESH_DESCRIPTOR_UI
DB02789 DRUGBANK_ID
CHEMBL2105373 ChEMBL_ID
2376 IUPHAR_LIGAND_ID

Pharmaceutical products:

None