pregabalin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
gabamimetic agents 2255 148553-50-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pregabalin
  • (S)-Pregabalin
  • gabanext
  • maxgalin
  • lyrica
  • pregabalin hydrochloride
  • pregabalin HCl
A gamma-aminobutyric acid (GABA) derivative that functions as a CALCIUM CHANNEL BLOCKER and is used as an ANTICONVULSANT as well as an ANTI-ANXIETY AGENT. It is also used as an ANALGESIC in the treatment of NEUROPATHIC PAIN and FIBROMYALGIA.
  • Molecular weight: 159.23
  • Formula: C8H17NO2
  • CLOGP: -0.92
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 63.32
  • ALOGS: -1.15
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.30 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 33 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 90 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 53.83 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 90 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
July 6, 2004 EMA
Dec. 30, 2004 FDA PF PRISM CV

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Withdrawal syndrome 1366.42 9.85 952 235836 17182 46432092
Somnolence 986.30 9.85 2338 234450 154183 46295091
Pain 829.09 9.85 4666 232122 472282 45976992
Weight increased 614.35 9.85 2032 234756 162441 46286833
Intentional product misuse 605.13 9.85 953 235835 46175 46403099
Feeling abnormal 572.58 9.85 1659 235129 123401 46325873
Therapeutic product effect incomplete 366.26 9.85 1046 235742 77107 46372167
Intentional product use issue 356.25 9.85 811 235977 51969 46397305
Memory impairment 351.70 9.85 1024 235764 76313 46372961
Fibromyalgia 344.89 9.85 644 236144 35819 46413455
Insomnia 308.09 9.85 1649 235139 163275 46285999
Dizziness 306.12 9.85 2847 233941 337567 46111707
Drug hypersensitivity 300.15 9.85 2190 234598 241635 46207639
Drug dependence 294.36 9.85 430 236358 19471 46429803
Gait disturbance 291.68 9.85 1482 235306 143781 46305493
Prescribed overdose 288.94 9.85 309 236479 10140 46439134
Death 271.05 9.85 839 235949 334709 46114565
Vision blurred 269.99 9.85 954 235834 78754 46370520
Neuralgia 262.75 9.85 424 236364 20959 46428315
Exposure during pregnancy 243.77 9.85 122 236666 108090 46341184
Sleep disorder 228.58 9.85 636 236152 46159 46403115
Maternal exposure during pregnancy 220.10 9.85 123 236665 102426 46346848
Drug withdrawal syndrome 216.92 9.85 449 236339 26935 46422339
Thinking abnormal 216.39 9.85 258 236530 9556 46439718
Pain in extremity 211.66 9.85 2122 234666 256558 46192716
Fall 210.94 9.85 2572 234216 326525 46122749
Confusional state 209.70 9.85 1459 235329 158433 46290841
Disturbance in attention 206.31 9.85 479 236309 31081 46418193
Tremor 203.46 9.85 1138 235650 114501 46334773
Pemphigus 201.86 9.85 6 236782 45268 46404006
Sciatica 201.54 9.85 353 236435 18667 46430607
Feeling drunk 198.97 9.85 162 236626 3725 46445549
Impaired driving ability 189.23 9.85 163 236625 4061 46445213
Burning sensation 188.44 9.85 574 236214 43837 46405437
Illness 183.48 9.85 266 236522 11958 46437316
Hypoacusis 173.39 9.85 350 236438 20619 46428655
Pre-existing condition improved 167.95 9.85 187 236601 6425 46442849
Body height decreased 164.15 9.85 223 236565 9429 46439845
Suicidal ideation 161.01 9.85 639 236149 55743 46393531
Speech disorder 159.60 9.85 474 236314 35693 46413581
Therapeutic response unexpected 155.40 9.85 282 236506 15334 46433940
Euphoric mood 154.24 9.85 146 236642 4126 46445148
Malaise 145.52 9.85 2423 234365 328809 46120465
Febrile neutropenia 144.40 9.85 160 236628 94467 46354807
Product use issue 129.49 9.85 873 235915 93771 46355503
Balance disorder 128.39 9.85 657 236131 63864 46385410
Myoclonus 127.64 9.85 247 236541 14105 46435169
Hypoaesthesia 116.97 9.85 1015 235773 117854 46331420
Diarrhoea 115.50 9.85 2072 234716 557530 45891744
Device expulsion 114.84 9.85 6 236782 27536 46421738
Visual impairment 113.04 9.85 650 236138 66039 46383235
Amnesia 109.47 9.85 460 236328 41171 46408103
Movement disorder 106.03 9.85 252 236536 16597 46432677
Injection site pain 105.87 9.85 242 236546 106910 46342364
Impaired work ability 105.75 9.85 212 236576 12424 46436850
Systemic lupus erythematosus 104.13 9.85 106 236682 65074 46384200
Drug ineffective for unapproved indication 103.85 9.85 246 236542 16167 46433107
Glossodynia 101.42 9.85 49 236739 44324 46404950
Product dispensing error 97.33 9.85 171 236617 9062 46440212
Injection site erythema 95.80 9.85 143 236645 74284 46374990
Neutropenia 94.67 9.85 389 236399 142815 46306459
Muscle twitching 94.02 9.85 221 236567 14451 46434823
Haemoglobin decreased 92.46 9.85 339 236449 128610 46320664
Hand deformity 92.43 9.85 30 236758 34544 46414730
Sopor 92.39 9.85 265 236523 19563 46429711
Dysstasia 92.09 9.85 246 236542 17422 46431852
Expired product administered 91.25 9.85 127 236661 5495 46443779
Diplopia 91.05 9.85 260 236528 19145 46430129
Alopecia 90.28 9.85 470 236318 161944 46287330
Anaemia 89.62 9.85 847 235941 254932 46194342
Disorientation 87.94 9.85 396 236392 36522 46412752
Crying 87.55 9.85 271 236517 20870 46428404
Infusion related reaction 87.26 9.85 245 236543 100963 46348311
Loss of personal independence in daily activities 87.07 9.85 542 236246 56641 46392633
Foetal exposure during pregnancy 87.07 9.85 24 236764 30723 46418551
Coma 84.48 9.85 546 236242 57803 46391471
Condition aggravated 82.18 9.85 1720 235068 243332 46205942
Drug effective for unapproved indication 80.47 9.85 65 236723 1477 46447797
Gastrointestinal haemorrhage 79.49 9.85 171 236617 77202 46372072
Sedation 78.16 9.85 275 236513 22635 46426639
Drug abuse 77.96 9.85 570 236218 62838 46386436
Mental impairment 76.98 9.85 185 236603 12271 46437003
Dyskinesia 75.56 9.85 319 236469 28606 46420668
Prescription drug used without a prescription 75.08 9.85 60 236728 1342 46447932
Pyrexia 75.06 9.85 1281 235507 347521 46101753
Back disorder 74.87 9.85 152 236636 8989 46440285
Atrial fibrillation 74.46 9.85 272 236516 103318 46345956
Cognitive disorder 73.64 9.85 376 236412 36507 46412767
Depressed level of consciousness 73.12 9.85 452 236336 47117 46402157
Paraesthesia 72.80 9.85 913 235875 116524 46332750
Respiratory depression 72.45 9.85 173 236615 11427 46437847
Hospitalisation 72.06 9.85 132 236656 63253 46386021
Muscle spasms 71.63 9.85 946 235842 122167 46327107
Injection site swelling 71.00 9.85 60 236728 40267 46409007
Product prescribing error 70.44 9.85 243 236545 19804 46429470
Gait inability 69.67 9.85 358 236430 34845 46414429
Depression 69.60 9.85 1231 235557 168873 46280401
Abdominal discomfort 68.86 9.85 466 236322 150699 46298575
Cardiac failure congestive 67.88 9.85 238 236550 91512 46357762
Sensitivity to weather change 67.23 9.85 109 236679 5407 46443867
Dysarthria 67.16 9.85 371 236417 37127 46412147
Dry mouth 66.51 9.85 492 236296 54434 46394840
Diabetic neuropathy 65.12 9.85 88 236700 3701 46445573
Dyspnoea 64.91 9.85 2057 234731 513491 45935783
Premature delivery 64.83 9.85 16 236772 22053 46427221
White blood cell count decreased 63.90 9.85 322 236466 111909 46337365
Pleural effusion 63.51 9.85 212 236576 82740 46366534
Injection site reaction 63.46 9.85 90 236698 47759 46401515
Platelet count decreased 63.42 9.85 276 236512 99748 46349526
Sepsis 63.10 9.85 417 236371 135597 46313677
Neuropathy peripheral 63.05 9.85 722 236066 90171 46359103
Nerve injury 62.96 9.85 128 236660 7577 46441697
Nervousness 62.33 9.85 298 236490 28177 46421097
Dysphemia 62.15 9.85 68 236720 2290 46446984
Oedema peripheral 61.89 9.85 1146 235642 158560 46290714
Drug ineffective 61.85 9.85 4105 232683 673733 45775541
Pericarditis 61.81 9.85 22 236766 23905 46425369
Hypotension 61.72 9.85 820 235968 231769 46217505
Psoriatic arthropathy 60.58 9.85 353 236435 36026 46413248
Abdominal pain 60.31 9.85 813 235975 229218 46220056
Multiple organ dysfunction syndrome 60.29 9.85 106 236682 51604 46397670
Mucosal inflammation 59.32 9.85 66 236722 38910 46410364
Dysgraphia 59.25 9.85 72 236716 2720 46446554
Irritability 59.12 9.85 297 236491 28649 46420625
Road traffic accident 58.59 9.85 257 236531 23434 46425840
Increased appetite 58.56 9.85 132 236656 8395 46440879
Pregnancy 57.53 9.85 33 236755 27104 46422170
Pancytopenia 57.46 9.85 229 236559 84829 46364445
Restlessness 56.51 9.85 268 236520 25256 46424018
Hallucination 56.31 9.85 440 236348 49511 46399763
Coronary artery disease 56.08 9.85 53 236735 33699 46415575
C-reactive protein abnormal 55.90 9.85 19 236769 21251 46428023
Vertigo 55.68 9.85 453 236335 51595 46397679
Hyperhidrosis 53.91 9.85 691 236097 88617 46360657
Product use in unapproved indication 53.88 9.85 697 236091 89576 46359698
Thrombocytopenia 53.35 9.85 399 236389 126182 46323092
Acute myocardial infarction 53.19 9.85 50 236738 31874 46417400
Chest pain 53.04 9.85 605 236183 175719 46273555
Anxiety 52.36 9.85 1250 235538 180707 46268567
Pneumonia 51.84 9.85 1483 235305 374837 46074437
Alanine aminotransferase increased 51.36 9.85 252 236536 88199 46361075
Rheumatoid factor positive 50.86 9.85 20 236768 20441 46428833
International normalised ratio fluctuation 50.57 9.85 59 236729 2134 46447140
Injection site pruritus 49.55 9.85 78 236710 39665 46409609
International normalised ratio increased 49.49 9.85 102 236686 46781 46402493
Pulmonary hypertension 49.44 9.85 66 236722 35927 46413347
Formication 49.34 9.85 79 236709 3877 46445397
Cough 48.98 9.85 847 235941 229402 46219872
Rheumatoid factor negative 48.50 9.85 32 236756 525 46448749
Premature baby 47.91 9.85 16 236772 18096 46431178
Wrong technique in product usage process 45.96 9.85 133 236655 54289 46394985
Loss of consciousness 44.12 9.85 783 236005 107455 46341819
Limb discomfort 43.25 9.85 229 236559 22547 46426727
Hepatotoxicity 43.06 9.85 38 236750 24971 46424303
Respiratory failure 42.80 9.85 293 236495 94523 46354751
Injection site warmth 42.42 9.85 9 236779 13763 46435511
Restless legs syndrome 42.36 9.85 176 236612 15667 46433607
Coordination abnormal 42.26 9.85 137 236651 10812 46438462
Accidental exposure to product 41.42 9.85 28 236760 21053 46428221
Stomatitis 41.15 9.85 192 236596 68105 46381169
Altered state of consciousness 41.13 9.85 230 236558 23118 46426156
Live birth 40.82 9.85 3 236785 10327 46438947
Trigeminal neuralgia 40.49 9.85 62 236726 2927 46446347
Drug resistance 39.96 9.85 19 236769 17349 46431925
Pneumonia aspiration 39.91 9.85 286 236502 31319 46417955
Hallucination, visual 39.80 9.85 188 236600 17685 46431589
Aspartate aminotransferase increased 39.72 9.85 235 236553 78465 46370809
Septic shock 39.64 9.85 155 236633 57738 46391536
Pulmonary arterial hypertension 39.35 9.85 44 236744 25884 46423390
Intervertebral disc protrusion 39.32 9.85 206 236582 20199 46429075
Vomiting 39.26 9.85 1887 234901 450907 45998367
Blood iron abnormal 39.12 9.85 63 236725 3107 46446167
Breakthrough pain 39.00 9.85 38 236750 1114 46448160
Psoriasis 38.99 9.85 236 236552 78368 46370906
Leukopenia 38.93 9.85 196 236592 68147 46381127
Renal failure 38.91 9.85 378 236410 113216 46336058
Cytomegalovirus infection 38.55 9.85 22 236766 18122 46431152
Bedridden 38.47 9.85 118 236670 9041 46440233
Infective pulmonary exacerbation of cystic fibrosis 37.85 9.85 5 236783 10802 46438472
Haematocrit decreased 37.23 9.85 76 236712 34981 46414293
Fluid overload 37.18 9.85 50 236738 27135 46422139
Overdose 37.14 9.85 725 236063 101254 46348020
Hepatic enzyme increased 36.28 9.85 254 236534 81533 46367741
Intentional self-injury 34.87 9.85 226 236562 23940 46425334
Injection site bruising 34.75 9.85 81 236707 35555 46413719
Frustration tolerance decreased 34.57 9.85 80 236708 5177 46444097
Myocardial infarction 34.48 9.85 322 236466 97206 46352068
Deep vein thrombosis 34.29 9.85 250 236538 79523 46369751
Neoplasm progression 33.61 9.85 52 236736 26631 46422643
Urinary retention 33.59 9.85 237 236551 25824 46423450
Hypoxia 33.48 9.85 142 236646 51696 46397578
Panic reaction 33.42 9.85 64 236724 3625 46445649
Bradyphrenia 32.72 9.85 87 236701 6143 46443131
Ventricular tachycardia 32.72 9.85 23 236765 16944 46432330
Neutrophil count decreased 32.54 9.85 112 236676 43314 46405960
Oedema 32.42 9.85 499 236289 66572 46382702
Productive cough 32.09 9.85 140 236648 50575 46398699
Epistaxis 31.93 9.85 193 236595 64112 46385162
Pulmonary embolism 31.68 9.85 375 236413 108210 46341064
Blood creatinine increased 31.15 9.85 243 236545 76160 46373114
Foetal death 30.73 9.85 4 236784 8739 46440535
Dependence 30.41 9.85 43 236745 1888 46447386
Peritonitis bacterial 30.31 9.85 4 236784 8649 46440625
Product quality issue 30.18 9.85 87 236701 35561 46413713
Torsade de pointes 30.01 9.85 12 236776 12142 46437132
Premature labour 29.85 9.85 10 236778 11289 46437985
Visual acuity reduced 29.62 9.85 203 236585 21910 46427364
Feeling of body temperature change 29.39 9.85 66 236722 4186 46445088
Nausea 29.39 9.85 3047 233741 684407 45764867
Full blood count decreased 29.22 9.85 42 236746 22169 46427105
Cardiac arrest 29.22 9.85 305 236483 90094 46359180
Affective disorder 29.20 9.85 71 236717 4744 46444530
Emotional disorder 29.19 9.85 132 236656 12192 46437082
Multiple allergies 29.15 9.85 93 236695 7278 46441996
Caesarean section 28.86 9.85 25 236763 16578 46432696
Flushing 28.49 9.85 201 236587 64413 46384861
Hypokalaemia 28.44 9.85 297 236491 87727 46361547
Injection site haemorrhage 28.41 9.85 38 236750 20671 46428603
Muscular weakness 28.24 9.85 637 236151 91207 46358067
Colitis 28.20 9.85 96 236692 37251 46412023
Therapy cessation 28.05 9.85 58 236730 26571 46422703
Device dislocation 27.93 9.85 42 236746 21760 46427514
Hypersomnia 27.80 9.85 153 236635 15286 46433988
Fatigue 27.77 9.85 2685 234103 606012 45843262
Cataract 27.65 9.85 352 236436 45063 46404211
Duodenal ulcer perforation 27.35 9.85 5 236783 8497 46440777
Blood bilirubin increased 27.10 9.85 86 236702 34098 46415176
Agitation 27.05 9.85 413 236375 55002 46394272
Ascites 26.97 9.85 95 236693 36489 46412785
Mood altered 26.94 9.85 134 236654 12873 46436401
Ejection fraction decreased 26.61 9.85 31 236757 17906 46431368
Dementia 26.25 9.85 147 236641 14783 46434491
Ankle fracture 26.14 9.85 151 236637 15360 46433914
Oxygen saturation decreased 25.91 9.85 225 236563 68939 46380335
Urticaria 25.90 9.85 431 236357 117461 46331813
Multiple sclerosis relapse 25.85 9.85 327 236461 41798 46407476
Paralysis 25.81 9.85 100 236688 8621 46440653
Diverticulitis 25.58 9.85 84 236704 32955 46416319
Hypomagnesaemia 25.46 9.85 46 236742 22164 46427110
Panic attack 25.46 9.85 183 236605 20059 46429215
Aggression 25.43 9.85 200 236588 22544 46426730
Pneumocystis jirovecii pneumonia 25.26 9.85 24 236764 15224 46434050
Lyme disease 25.21 9.85 44 236744 2319 46446955
Pre-eclampsia 25.08 9.85 5 236783 7989 46441285
Pulmonary oedema 25.04 9.85 154 236634 50951 46398323
Decreased appetite 24.83 9.85 771 236017 193065 46256209
Acute myeloid leukaemia 24.80 9.85 26 236762 15752 46433522
Right ventricular failure 24.76 9.85 27 236761 16066 46433208
Eosinophilic colitis 24.68 9.85 12 236776 105 46449169
Device malfunction 24.66 9.85 19 236769 13355 46435919
Nightmare 24.42 9.85 156 236632 16442 46432832
Erythema 24.38 9.85 545 236243 142275 46306999
Fungal infection 24.30 9.85 73 236715 29447 46419827
Metastases to bone 24.04 9.85 32 236756 17444 46431830
Breast cancer 23.99 9.85 134 236654 45384 46403890
Reading disorder 23.99 9.85 24 236764 727 46448547
Chest discomfort 23.98 9.85 318 236470 89951 46359323
Uterine perforation 23.98 9.85 4 236784 7263 46442011
Rectal haemorrhage 23.96 9.85 106 236682 38149 46411125
Bone erosion 23.85 9.85 9 236779 9434 46439840
Complication associated with device 23.65 9.85 26 236762 15415 46433859
Tension 23.58 9.85 48 236740 2844 46446430
Poor quality sleep 23.47 9.85 145 236643 15108 46434166
Drug tolerance 23.43 9.85 51 236737 3167 46446107
Bloody discharge 23.42 9.85 27 236761 964 46448310
Depressed mood 23.23 9.85 265 236523 33054 46416220
Hyperaesthesia 23.18 9.85 90 236698 7766 46441508
Wound 23.11 9.85 125 236663 42677 46406597
Basal cell carcinoma 22.98 9.85 43 236745 20444 46428830
Impaired healing 22.90 9.85 102 236686 36641 46412633
Acute respiratory distress syndrome 22.88 9.85 48 236740 21874 46427400
Therapy non-responder 22.87 9.85 119 236669 41033 46408241
Abnormal dreams 22.80 9.85 108 236680 10171 46439103
Intentional dose omission 22.67 9.85 51 236737 3239 46446035
Pericardial effusion 22.62 9.85 61 236727 25482 46423792
Left ventricular dysfunction 22.42 9.85 12 236776 10243 46439031
Device issue 22.35 9.85 42 236746 19938 46429336
Musculoskeletal stiffness 22.31 9.85 653 236135 97340 46351934
Synovial fluid analysis 22.15 9.85 31 236757 1348 46447926
Respiratory distress 22.13 9.85 85 236703 31831 46417443
Treatment noncompliance 22.05 9.85 77 236711 29654 46419620
Epilepsy 21.92 9.85 200 236588 23538 46425736
Peritonitis 21.91 9.85 45 236743 20669 46428605
Myelosuppression 21.83 9.85 6 236782 7697 46441577
Tenosynovitis stenosans 21.72 9.85 37 236751 1912 46447362
Adverse drug reaction 21.57 9.85 134 236654 44228 46405046
Electrocardiogram QT prolonged 21.50 9.85 162 236626 51163 46398111
Dissociation 21.41 9.85 36 236752 1841 46447433
Candida infection 21.32 9.85 51 236737 22189 46427085
Urinary tract infection 21.24 9.85 907 235881 219359 46229915
Ataxia 21.17 9.85 132 236656 13798 46435476
Completed suicide 21.04 9.85 571 236217 145349 46303925
Hostility 20.97 9.85 30 236758 1332 46447942
Multiple sclerosis 20.96 9.85 205 236583 24586 46424688
Carpal tunnel syndrome 20.89 9.85 145 236643 15714 46433560
Small intestinal obstruction 20.87 9.85 31 236757 16141 46433133
Dyslexia 20.82 9.85 13 236775 193 46449081
Rash pruritic 20.76 9.85 135 236653 44080 46405194
Anorgasmia 20.76 9.85 20 236768 578 46448696
Product dose omission issue 20.69 9.85 674 236114 167846 46281428
Body mass index increased 20.67 9.85 26 236762 1018 46448256
Leukocytosis 20.62 9.85 56 236732 23342 46425932
Sinus tachycardia 20.48 9.85 50 236738 21599 46427675
Rash erythematous 20.43 9.85 97 236691 34253 46415021
Myelodysplastic syndrome 20.38 9.85 30 236758 15681 46433593
Ventricular fibrillation 20.36 9.85 17 236771 11479 46437795
Eyelid injury 20.28 9.85 6 236782 9 46449265
Acute kidney injury 20.15 9.85 984 235804 234871 46214403
Allodynia 20.10 9.85 19 236769 536 46448738
Intervertebral disc disorder 20.09 9.85 56 236732 4066 46445208
Lung infiltration 20.06 9.85 25 236763 14018 46435256
Visual field defect 19.87 9.85 72 236716 6011 46443263
Nail growth abnormal 19.84 9.85 18 236770 481 46448793
Intentional overdose 19.82 9.85 450 236338 64494 46384780
Cardio-respiratory arrest 19.75 9.85 201 236587 59668 46389606
Coagulopathy 19.73 9.85 40 236748 18459 46430815
Heart rate increased 19.67 9.85 264 236524 74527 46374747
Device difficult to use 19.60 9.85 8 236780 7996 46441278
Hypercalcaemia 19.60 9.85 49 236739 20997 46428277
Delirium 19.55 9.85 281 236507 36947 46412327
Dyspepsia 19.38 9.85 238 236550 68234 46381040
Drug screen false positive 19.24 9.85 23 236765 854 46448420
Abdominal pain lower 19.20 9.85 50 236738 21131 46428143
Tenderness 19.18 9.85 149 236639 16732 46432542
Spinal stenosis 19.15 9.85 119 236669 12424 46436850
Eyelid skin dryness 19.13 9.85 8 236780 47 46449227
Hypokinesia 18.93 9.85 110 236678 11212 46438062
Ill-defined disorder 18.89 9.85 71 236717 26756 46422518
Foetal growth restriction 18.83 9.85 5 236783 6562 46442712
Injection site rash 18.81 9.85 32 236756 15781 46433493
Blood count abnormal 18.78 9.85 39 236749 17839 46431435
Tunnel vision 18.71 9.85 19 236769 586 46448688
Body temperature increased 18.70 9.85 64 236724 24797 46424477
Hip arthroplasty 18.61 9.85 40 236748 18072 46431202
Lymphadenopathy 18.52 9.85 97 236691 33391 46415883
Drug use disorder 18.40 9.85 42 236746 2693 46446581
Colitis ulcerative 18.36 9.85 39 236749 17693 46431581
Abnormal behaviour 18.23 9.85 175 236613 20883 46428391
Dehydration 18.20 9.85 644 236144 158896 46290378
Libido increased 18.19 9.85 21 236767 751 46448523
Hyperglycaemia 18.07 9.85 104 236684 34967 46414307
Palmar-plantar erythrodysaesthesia syndrome 17.99 9.85 49 236739 20402 46428872
Myocardial ischaemia 17.89 9.85 23 236765 12726 46436548
Cervix neoplasm 17.87 9.85 12 236776 203 46449071
Cardiogenic shock 17.84 9.85 35 236753 16349 46432925
Pseudomonas infection 17.82 9.85 14 236774 9744 46439530
Hypersensitivity 17.79 9.85 604 236184 149717 46299557
Haemorrhage 17.77 9.85 185 236603 54684 46394590
Red blood cell sedimentation rate abnormal 17.77 9.85 26 236762 13623 46435651
Cholelithiasis 17.71 9.85 119 236669 38562 46410712
Somnambulism 17.64 9.85 61 236727 4976 46444298
Device breakage 17.58 9.85 14 236774 9678 46439596
Spinal disorder 17.57 9.85 84 236704 7940 46441334
Head titubation 17.55 9.85 19 236769 632 46448642
Musculoskeletal pain 17.54 9.85 473 236315 69655 46379619
Cold sweat 17.44 9.85 105 236683 10840 46438434
Skull fracture 17.44 9.85 22 236766 864 46448410
Sensory disturbance 17.26 9.85 114 236674 12153 46437121
Granulocytopenia 17.18 9.85 3 236785 5270 46444004
Drug screen positive 17.16 9.85 51 236737 3840 46445434
Knee arthroplasty 17.08 9.85 62 236726 23603 46425671
Miosis 17.06 9.85 73 236715 6584 46442690
Middle insomnia 16.93 9.85 94 236694 9421 46439853
Cardiomyopathy 16.93 9.85 35 236753 16038 46433236
Central obesity 16.82 9.85 21 236767 816 46448458
Melaena 16.77 9.85 78 236710 27694 46421580
Glaucoma 16.71 9.85 138 236650 15783 46433491
Aspergillus infection 16.69 9.85 7 236781 6883 46442391
Clostridium difficile colitis 16.66 9.85 44 236744 18509 46430765
Gastritis 16.63 9.85 104 236684 34274 46415000
General physical health deterioration 16.60 9.85 732 236056 115037 46334237
White blood cell count abnormal 16.55 9.85 3 236785 5129 46444145
Parkinsonism 16.54 9.85 82 236706 7866 46441408
Metastases to liver 16.43 9.85 48 236740 19537 46429737
Limb injury 16.43 9.85 159 236629 19015 46430259
Dysuria 16.21 9.85 214 236574 27619 46421655
Lower respiratory tract infection 16.15 9.85 190 236598 54899 46394375
Obstructive airways disorder 16.08 9.85 27 236761 13385 46435889
Platelet count increased 16.00 9.85 32 236756 14842 46434432
Anger 15.99 9.85 109 236679 11743 46437531
Nephropathy toxic 15.89 9.85 9 236779 7445 46441829
Head injury 15.87 9.85 193 236595 24443 46424831
Throat irritation 15.82 9.85 84 236704 28817 46420457
Tooth extraction 15.79 9.85 17 236771 10176 46439098
Poor quality product administered 15.78 9.85 42 236746 2967 46446307
Feeling cold 15.76 9.85 155 236633 18616 46430658
Osteonecrosis 15.72 9.85 72 236716 25672 46423602
Disease progression 15.68 9.85 348 236440 90952 46358322
Stress 15.67 9.85 357 236431 51194 46398080
Negative thoughts 15.47 9.85 20 236768 805 46448469
Nervous system disorder 15.45 9.85 137 236651 15992 46433282
Injection site urticaria 15.38 9.85 23 236765 11944 46437330
Oropharyngeal pain 15.36 9.85 274 236514 73894 46375380
Gingival bleeding 15.32 9.85 22 236766 11617 46437657
Cerebrospinal fluid retention 15.20 9.85 8 236780 84 46449190
Pain in jaw 15.19 9.85 123 236665 38249 46411025
Pulmonary haemorrhage 15.14 9.85 7 236781 6498 46442776
Vascular access site infection 15.14 9.85 6 236782 30 46449244
Auditory disorder 15.06 9.85 15 236773 452 46448822
Vascular access site thrombosis 14.98 9.85 6 236782 31 46449243
Abortion induced 14.93 9.85 18 236770 10242 46439032
Dyspnoea exertional 14.92 9.85 173 236615 50116 46399158
Diverticulum intestinal 14.86 9.85 6 236782 6035 46443239
Asthma 14.86 9.85 352 236436 91190 46358084
Injury 14.86 9.85 147 236641 43880 46405394
Inappropriate schedule of product administration 14.82 9.85 236 236552 64777 46384497
Pulmonary mass 14.81 9.85 44 236744 17813 46431461
Cellulitis 14.77 9.85 259 236529 70029 46379245
Hepatic failure 14.70 9.85 104 236684 33312 46415962
Normal newborn 14.70 9.85 6 236782 5995 46443279
Drug intolerance 14.62 9.85 898 235890 146151 46303123
Incorrect route of product administration 14.60 9.85 39 236749 16344 46432930
Spinal pain 14.57 9.85 93 236695 9799 46439475
Accommodation disorder 14.50 9.85 13 236775 342 46448932
Laboratory test abnormal 14.49 9.85 63 236725 22784 46426490
Anal sphincter atony 14.43 9.85 11 236777 229 46449045
Infusion site pain 14.43 9.85 18 236770 10089 46439185
Nerve compression 14.40 9.85 71 236717 6797 46442477
Device use error 14.32 9.85 4 236784 5077 46444197
Proteinuria 14.30 9.85 40 236748 16513 46432761
Neuropathic arthropathy 14.27 9.85 11 236777 233 46449041
Forceps delivery 14.22 9.85 10 236778 183 46449091
Pneumonia viral 14.12 9.85 8 236780 6616 46442658
Upper respiratory tract infection 14.06 9.85 232 236556 63324 46385950
Graft versus host disease 13.98 9.85 8 236780 6580 46442694
Cardiac output decreased 13.91 9.85 20 236768 892 46448382
Haematotoxicity 13.90 9.85 9 236779 6924 46442350
Supraventricular tachycardia 13.89 9.85 29 236759 13241 46436033
Mitral valve incompetence 13.86 9.85 49 236739 18803 46430471
Neurosis 13.86 9.85 12 236776 301 46448973
Hiatus hernia 13.84 9.85 47 236741 18255 46431019
Electrocardiogram ST-T segment abnormal 13.84 9.85 11 236777 244 46449030
Cardiomegaly 13.84 9.85 44 236744 17438 46431836
Fracture 13.82 9.85 136 236652 16335 46432939
Tobacco abuse 13.81 9.85 17 236771 651 46448623
Cardiac murmur 13.63 9.85 23 236765 11381 46437893
Renal injury 13.61 9.85 17 236771 9524 46439750
Hernia 13.58 9.85 90 236698 9605 46439669
Product prescribing issue 13.58 9.85 20 236768 912 46448362
White blood cell count increased 13.55 9.85 151 236637 44068 46405206
Therapeutic product effect delayed 13.55 9.85 30 236758 1885 46447389
Feeling jittery 13.54 9.85 99 236689 10909 46438365
Neck pain 13.54 9.85 372 236416 54934 46394340
Body tinea 13.53 9.85 20 236768 915 46448359
Neurotoxicity 13.52 9.85 31 236757 13686 46435588
Panniculitis 13.49 9.85 6 236782 5698 46443576
Social anxiety disorder 13.48 9.85 13 236775 376 46448898
Eosinophil count increased 13.48 9.85 12 236776 7854 46441420
Hyperprolactinaemia 13.47 9.85 39 236749 2893 46446381
Hospice care 13.45 9.85 5 236783 5290 46443984
Dysaesthesia 13.45 9.85 41 236747 3130 46446144
Temperature intolerance 13.44 9.85 75 236713 7532 46441742
Eye disorder 13.43 9.85 146 236642 17995 46431279
Bronchopulmonary aspergillosis 13.38 9.85 11 236777 7485 46441789
Tubulointerstitial nephritis 13.33 9.85 35 236753 14753 46434521
Oesophagitis 13.33 9.85 31 236757 13620 46435654
Unintended pregnancy 13.32 9.85 6 236782 5654 46443620
Language disorder 13.28 9.85 26 236762 1497 46447777
Mental status changes postoperative 13.25 9.85 10 236778 205 46449069
Monocyte count abnormal 13.25 9.85 10 236778 205 46449069
Cytopenia 13.13 9.85 12 236776 7756 46441518
Herpes zoster 13.00 9.85 443 236345 67429 46381845
Pulmonary fibrosis 12.99 9.85 55 236733 20037 46429237
Facial neuralgia 12.98 9.85 8 236780 116 46449158
Nasal congestion 12.95 9.85 169 236619 47944 46401330
Apparent death 12.95 9.85 24 236764 1326 46447948
Dysgeusia 12.92 9.85 137 236651 40354 46408920
Monoplegia 12.90 9.85 35 236753 2501 46446773
Foaming at mouth 12.90 9.85 22 236766 1138 46448136
Heparin-induced thrombocytopenia 12.90 9.85 3 236785 4306 46444968
Synovitis 12.85 9.85 225 236563 60850 46388424
Anti-actin antibody positive 12.80 9.85 4 236784 8 46449266
Bone marrow failure 12.73 9.85 93 236695 29576 46419698
Cholecystitis chronic 12.71 9.85 21 236767 10478 46438796
Scleritis 12.68 9.85 38 236750 2874 46446400
Pulmonary toxicity 12.67 9.85 4 236784 4689 46444585
Confusion postoperative 12.61 9.85 10 236778 221 46449053
Abnormal weight gain 12.61 9.85 25 236763 1453 46447821
Oral candidiasis 12.61 9.85 46 236742 17486 46431788
Pancreatitis 12.58 9.85 151 236637 43476 46405798
Cardiac failure 12.54 9.85 309 236479 79639 46369635
Colitis microscopic 12.49 9.85 9 236779 6547 46442727
Aphasia 12.47 9.85 209 236579 28358 46420916
Respiratory tract congestion 12.45 9.85 29 236759 12735 46436539
Neck injury 12.44 9.85 27 236761 1673 46447601
Inadequate analgesia 12.44 9.85 37 236751 2787 46446487
Low birth weight baby 12.41 9.85 6 236782 5428 46443846
Haemorrhoids 12.39 9.85 51 236737 18726 46430548
Myofascial pain syndrome 12.38 9.85 29 236759 1892 46447382
Hippocampal sclerosis 12.35 9.85 7 236781 86 46449188
Motor dysfunction 12.34 9.85 71 236717 7211 46442063
Atrial flutter 12.33 9.85 17 236771 9131 46440143
Renal cell carcinoma stage I 12.30 9.85 5 236783 27 46449247
Atonic urinary bladder 12.28 9.85 7 236781 87 46449187
Herpes zoster oticus 12.28 9.85 10 236778 230 46449044
Diarrhoea haemorrhagic 12.23 9.85 12 236776 7497 46441777
Product complaint 12.21 9.85 27 236761 12074 46437200
Tongue necrosis 12.20 9.85 4 236784 10 46449264
Therapeutic response decreased 12.19 9.85 150 236638 42995 46406279
Haematuria 12.11 9.85 83 236705 26775 46422499
Crepitations 12.08 9.85 62 236726 6030 46443244
Facial pain 12.05 9.85 73 236715 7552 46441722
Macular degeneration 12.05 9.85 70 236718 7135 46442139
Complex regional pain syndrome 12.04 9.85 30 236758 2036 46447238
Congestive cardiomyopathy 12.03 9.85 7 236781 5706 46443568
Neutropenic sepsis 12.02 9.85 28 236760 12296 46436978
Laryngeal disorder 11.99 9.85 18 236770 835 46448439
Pathogen resistance 11.97 9.85 8 236780 6052 46443222
Tricuspid valve incompetence 11.96 9.85 33 236755 13684 46435590
Hunger 11.93 9.85 45 236743 3830 46445444
Holmes-Adie pupil 11.87 9.85 5 236783 30 46449244
Corrective lens user 11.86 9.85 9 236779 186 46449088
Acute coronary syndrome 11.81 9.85 21 236767 10183 46439091
Hyponatraemia 11.78 9.85 408 236380 100924 46348350
Lower limb fracture 11.72 9.85 105 236683 12293 46436981
Acute respiratory failure 11.72 9.85 93 236695 29045 46420229
Cerebral ventricular rupture 11.70 9.85 9 236779 190 46449084
Plasma cell myeloma 11.69 9.85 157 236631 44321 46404953
Burning feet syndrome 11.67 9.85 4 236784 12 46449262
Cerebral haemorrhage 11.67 9.85 90 236698 28281 46420993
Vertigo CNS origin 11.60 9.85 5 236783 32 46449242
Suspected counterfeit product 11.53 9.85 11 236777 314 46448960
Intentional underdose 11.52 9.85 28 236760 1870 46447404
Blood alkaline phosphatase increased 11.46 9.85 137 236651 39472 46409802
Back injury 11.42 9.85 67 236721 6854 46442420
Neoplasm malignant 11.41 9.85 175 236613 23324 46425950
Drug dose titration not performed 11.38 9.85 12 236776 387 46448887
Frequent bowel movements 11.31 9.85 30 236758 12602 46436672
Diverticulum 11.31 9.85 25 236763 11181 46438093
Maternal drugs affecting foetus 11.29 9.85 7 236781 5511 46443763
Chronic kidney disease 11.21 9.85 143 236645 40728 46408546
Folliculitis 11.20 9.85 9 236779 6194 46443080
Aura 11.18 9.85 19 236769 980 46448294
Upper-airway cough syndrome 11.17 9.85 14 236774 7833 46441441
Pulmonary tuberculosis 11.15 9.85 5 236783 4726 46444548
Arteriosclerosis coronary artery 11.15 9.85 15 236773 8141 46441133
Rib fracture 11.15 9.85 146 236642 18808 46430466
Antinuclear antibody positive 11.15 9.85 62 236726 6218 46443056
Abortion spontaneous 11.14 9.85 155 236633 43491 46405783
Respiratory rate increased 11.13 9.85 26 236762 11407 46437867
Apathy 11.12 9.85 69 236719 7199 46442075
Clostridium difficile infection 11.11 9.85 78 236710 25025 46424249
Lymphocyte count abnormal 11.08 9.85 15 236773 632 46448642
Phantom limb syndrome 11.03 9.85 8 236780 154 46449120
Bacteraemia 11.01 9.85 36 236752 14143 46435131
Aplastic anaemia 11.01 9.85 12 236776 7141 46442133
Blindness 11.00 9.85 135 236653 17134 46432140
Blood lactate dehydrogenase increased 10.99 9.85 60 236728 20440 46428834
Indifference 10.98 9.85 7 236781 108 46449166
Oropharyngeal blistering 10.91 9.85 17 236771 815 46448459
Nephrolithiasis 10.88 9.85 111 236677 32940 46416334
Mite allergy 10.85 9.85 12 236776 409 46448865
Dry eye 10.83 9.85 215 236573 30107 46419167
Crohn's disease 10.82 9.85 11 236777 6760 46442514
Thought blocking 10.81 9.85 7 236781 111 46449163
Optic nerve cupping 10.80 9.85 3 236785 3 46449271
Limb fracture 10.80 9.85 3 236785 3 46449271
Myoglobin urine 10.80 9.85 4 236784 16 46449258
Sciatic nerve injury 10.76 9.85 11 236777 342 46448932
Haemophagocytic lymphohistiocytosis 10.75 9.85 16 236772 8326 46440948
Perfume sensitivity 10.71 9.85 14 236774 570 46448704
Encephalitis brain stem 10.71 9.85 7 236781 113 46449161
Dry skin 10.70 9.85 145 236643 40871 46408403
Granuloma 10.69 9.85 3 236785 3795 46445479
Heart rate decreased 10.67 9.85 106 236682 31617 46417657
Erythema multiforme 10.66 9.85 85 236703 9619 46439655
Sleep attacks 10.64 9.85 6 236782 73 46449201
Histone antibody positive 10.64 9.85 6 236782 73 46449201
Cerebral infarction 10.64 9.85 72 236716 23294 46425980
Generalised anxiety disorder 10.63 9.85 25 236763 1635 46447639
Tracheal oedema 10.61 9.85 4 236784 17 46449257
Malnutrition 10.56 9.85 36 236752 13967 46435307
Device related infection 10.52 9.85 63 236725 20978 46428296
Infusion site erythema 10.50 9.85 14 236774 7628 46441646
Failure to thrive 10.45 9.85 11 236777 6653 46442621
Atrial septal defect 10.45 9.85 10 236778 6322 46442952
Incoherent 10.44 9.85 48 236740 4464 46444810
Gastric bypass 10.43 9.85 22 236766 1337 46447937
Pituitary tumour benign 10.42 9.85 25 236763 1656 46447618
Mastocytosis 10.42 9.85 12 236776 428 46448846
Serum ferritin increased 10.40 9.85 7 236781 5276 46443998
Fear of injection 10.40 9.85 4 236784 4143 46445131
Ligament pain 10.36 9.85 8 236780 170 46449104
Seizure 10.35 9.85 741 236047 122313 46326961
Dolichocolon 10.35 9.85 3 236785 4 46449270
Weight abnormal 10.34 9.85 18 236770 947 46448327
Homicidal ideation 10.32 9.85 26 236762 1776 46447498
Femur fracture 10.31 9.85 129 236659 36868 46412406
Pregnancy with contraceptive device 10.24 9.85 5 236783 4498 46444776
Streptococcal infection 10.24 9.85 6 236782 4872 46444402
Cystic fibrosis 10.22 9.85 3 236785 3685 46445589
Hepatic cirrhosis 10.21 9.85 43 236745 15689 46433585
Liver function test abnormal 10.18 9.85 170 236618 46317 46402957
Second primary malignancy 10.18 9.85 11 236777 6573 46442701
Drug level decreased 10.16 9.85 9 236779 5903 46443371
Loss of control of legs 10.15 9.85 22 236766 1362 46447912
Bursitis infective 10.15 9.85 20 236768 1157 46448117
Cytomegalovirus viraemia 10.15 9.85 5 236783 4473 46444801
Peripheral coldness 10.12 9.85 85 236703 9770 46439504
Activated partial thromboplastin time prolonged 10.12 9.85 12 236776 6877 46442397
Upper gastrointestinal haemorrhage 10.11 9.85 47 236741 16691 46432583
Renal tubular necrosis 10.06 9.85 25 236763 10734 46438540
Physical deconditioning 10.02 9.85 10 236778 302 46448972
Rhinovirus infection 9.99 9.85 3 236785 3633 46445641
Eating disorder 9.97 9.85 116 236672 14538 46434736
Hereditary angioedema 9.96 9.85 8 236780 5508 46443766
Self esteem decreased 9.95 9.85 13 236775 529 46448745
Visual brightness 9.93 9.85 4 236784 21 46449253
Behaviour disorder 9.91 9.85 27 236761 1934 46447340
Ligament sprain 9.90 9.85 89 236699 10430 46438844
Clumsiness 9.90 9.85 25 236763 1711 46447563
Mandibular mass 9.86 9.85 8 236780 183 46449091
Dialysis 9.86 9.85 23 236765 10093 46439181

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Withdrawal syndrome 590.35 10.28 429 117397 10821 29823831
Somnolence 565.99 10.28 1204 116622 95559 29739093
Pain 427.37 10.28 1569 116257 171072 29663580
Drug abuse 351.08 10.28 904 116922 81168 29753484
Drug dependence 341.37 10.28 420 117406 20875 29813777
Intentional product misuse 291.77 10.28 504 117322 34163 29800489
Prescribed overdose 208.17 10.28 210 117616 8351 29826301
Burning sensation 208.09 10.28 289 117537 16185 29818467
Feeling abnormal 201.36 10.28 584 117242 56172 29778480
Drug hypersensitivity 178.39 10.28 634 117192 67885 29766767
Therapeutic product effect incomplete 168.08 10.28 395 117431 33439 29801213
Neuralgia 166.98 10.28 206 117620 10260 29824392
Suicidal ideation 154.35 10.28 398 117428 35716 29798936
Memory impairment 143.01 10.28 394 117432 36780 29797872
Prescription drug used without a prescription 141.83 10.28 78 117748 1184 29833468
Overdose 140.30 10.28 680 117146 83657 29750995
Vision blurred 139.41 10.28 421 117405 41395 29793257
Drug withdrawal syndrome 137.43 10.28 265 117561 19544 29815108
Pain in extremity 135.46 10.28 818 117008 109403 29725249
Insomnia 129.88 10.28 716 117110 92620 29742032
Death 126.31 10.28 856 116970 356427 29478225
Gait disturbance 124.40 10.28 603 117223 74174 29760478
Weight increased 120.98 10.28 599 117227 74314 29760338
Coma 118.98 10.28 390 117436 40059 29794593
Pre-existing condition improved 115.72 10.28 81 117745 1920 29832732
Drug use disorder 110.41 10.28 96 117730 3152 29831500
Myoclonus 108.60 10.28 191 117635 13121 29821531
Dizziness 107.33 10.28 1205 116621 193704 29640948
Disturbance in attention 106.24 10.28 255 117571 21874 29812778
Pyrexia 104.20 10.28 705 117121 293784 29540868
Euphoric mood 100.22 10.28 103 117723 4187 29830465
Confusional state 97.99 10.28 883 116943 133951 29700701
Hypoaesthesia 93.54 10.28 442 117384 53788 29780864
Hypoacusis 93.03 10.28 185 117641 13954 29820698
Intentional product use issue 91.18 10.28 333 117493 36107 29798545
Febrile neutropenia 91.00 10.28 176 117650 106517 29728135
Toxicity to various agents 89.71 10.28 1078 116748 176105 29658547
Fall 89.69 10.28 1101 116725 180771 29653881
Intentional overdose 87.41 10.28 359 117467 41122 29793530
Diarrhoea 85.79 10.28 871 116955 333232 29501420
Depressed level of consciousness 84.68 10.28 336 117490 37886 29796766
Miosis 84.42 10.28 127 117699 7649 29827003
Dysarthria 82.59 10.28 286 117540 30204 29804448
Anaemia 79.51 10.28 486 117340 207506 29627146
Balance disorder 70.79 10.28 308 117518 36185 29798467
Hypotension 69.36 10.28 483 117343 200082 29634570
Road traffic accident 68.68 10.28 184 117642 16887 29817765
Amnesia 68.37 10.28 231 117595 24090 29810562
Feeling drunk 65.68 10.28 53 117773 1566 29833086
Neuropathy peripheral 65.37 10.28 488 117338 69987 29764665
Therapeutic response unexpected 64.07 10.28 121 117705 8782 29825870
Impaired work ability 62.45 10.28 93 117733 5550 29829102
C-reactive protein abnormal 61.65 10.28 92 117734 5501 29829151
Respiratory depression 61.16 10.28 138 117688 11365 29823287
Visual impairment 60.65 10.28 259 117567 30179 29804473
Fibromyalgia 59.61 10.28 62 117764 2556 29832096
Hyperaesthesia 58.07 10.28 71 117755 3502 29831150
Atrial fibrillation 57.87 10.28 224 117602 107900 29726752
Paraesthesia 57.84 10.28 389 117437 53938 29780714
Impaired driving ability 56.20 10.28 59 117767 2459 29832193
Sedation 54.67 10.28 165 117661 16208 29818444
Suicide attempt 52.62 10.28 284 117542 36413 29798239
Thinking abnormal 52.40 10.28 83 117743 5228 29829424
Drug ineffective 52.36 10.28 1728 116098 338659 29495993
Cytology abnormal 51.33 10.28 27 117799 373 29834279
Nerve injury 51.29 10.28 61 117765 2922 29831730
Middle insomnia 51.24 10.28 86 117740 5687 29828965
Ascites 50.87 10.28 40 117786 35881 29798771
Tremor 50.84 10.28 486 117340 74877 29759775
Drug intolerance 49.83 10.28 327 117499 44964 29789688
Cardiac failure congestive 49.02 10.28 169 117657 84238 29750414
Cytomegalovirus infection 48.97 10.28 16 117810 23658 29810994
Drug tolerance 48.86 10.28 51 117775 2111 29832541
Herpes zoster 48.67 10.28 240 117586 29703 29804949
Neutropenia 47.14 10.28 304 117522 128236 29706416
Coronary artery disease 46.85 10.28 77 117749 49635 29785017
Sopor 44.74 10.28 119 117707 10872 29823780
Product prescribing error 44.47 10.28 156 117670 16577 29818075
Limb discomfort 44.19 10.28 105 117721 8945 29825707
Gastrointestinal haemorrhage 43.91 10.28 174 117652 83272 29751380
Speech disorder 43.85 10.28 202 117624 24310 29810342
Multiple organ dysfunction syndrome 43.35 10.28 118 117708 63369 29771283
Movement disorder 42.27 10.28 109 117717 9774 29824878
Pneumonia 40.24 10.28 1005 116821 333301 29501351
Altered state of consciousness 40.06 10.28 170 117656 19749 29814903
Prescription form tampering 39.96 10.28 26 117800 544 29834108
Agitation 38.60 10.28 353 117473 53720 29780932
Cardiac arrest 38.57 10.28 211 117615 92639 29742013
Dry mouth 38.46 10.28 185 117641 22665 29811987
Respiratory failure 37.92 10.28 236 117590 100406 29734246
Dependence 37.23 10.28 34 117792 1192 29833460
Diplopia 37.12 10.28 129 117697 13643 29821009
Cough 37.04 10.28 316 117510 125326 29709326
Arthropathy 36.48 10.28 170 117656 20557 29814095
Dysstasia 36.14 10.28 107 117719 10398 29824254
Hospitalisation 36.12 10.28 75 117751 44244 29790408
Sleep disorder due to general medical condition, insomnia type 35.75 10.28 33 117793 1173 29833479
Sleep disorder 34.78 10.28 189 117637 24290 29810362
Dyspnoea 34.62 10.28 1023 116803 332272 29502380
Disease progression 34.57 10.28 179 117647 79695 29754957
Acute myocardial infarction 34.21 10.28 101 117725 52838 29781814
Nervousness 34.04 10.28 113 117713 11675 29822977
Condition aggravated 33.41 10.28 743 117083 137123 29697529
Prerenal failure 33.40 10.28 39 117787 1832 29832820
Illness 33.22 10.28 52 117774 3242 29831410
Foetal exposure during pregnancy 33.00 10.28 59 117767 36812 29797840
Interstitial lung disease 32.90 10.28 372 117454 59825 29774827
Allodynia 32.87 10.28 24 117802 609 29834043
Dysgraphia 32.62 10.28 35 117791 1496 29833156
Post herpetic neuralgia 32.50 10.28 29 117797 986 29833666
Intervertebral disc protrusion 32.44 10.28 95 117731 9176 29825476
Drug ineffective for unapproved indication 32.05 10.28 105 117721 10775 29823877
Inadequate analgesia 31.95 10.28 46 117780 2662 29831990
Mucosal inflammation 31.85 10.28 44 117782 30450 29804202
Oedematous pancreatitis 31.85 10.28 19 117807 339 29834313
Trigeminal neuralgia 31.71 10.28 27 117799 861 29833791
Product use issue 31.63 10.28 298 117528 45718 29788934
Colour blindness acquired 31.58 10.28 12 117814 71 29834581
Erectile dysfunction 31.51 10.28 148 117678 17954 29816698
Suicide threat 31.40 10.28 9 117817 17 29834635
Therapy non-responder 31.27 10.28 42 117784 29411 29805241
Restlessness 31.11 10.28 173 117653 22426 29812226
Terminal state 31.07 10.28 53 117773 3551 29831101
Cognitive disorder 31.06 10.28 179 117647 23511 29811141
Housebound 29.94 10.28 15 117811 186 29834466
Myocardial infarction 29.84 10.28 333 117493 125292 29709360
Phantom limb syndrome 29.64 10.28 17 117809 281 29834371
Anxiety 29.43 10.28 507 117319 89364 29745288
Bradypnoea 29.33 10.28 37 117789 1884 29832768
Dyskinesia 29.30 10.28 166 117660 21668 29812984
Sepsis 29.15 10.28 403 117423 145992 29688660
Apparent death 29.11 10.28 51 117775 3491 29831161
Anorgasmia 28.99 10.28 22 117804 593 29834059
Ataxia 28.86 10.28 105 117721 11357 29823295
Dysphemia 28.34 10.28 32 117794 1449 29833203
Blood bilirubin increased 28.19 10.28 64 117762 36572 29798080
Loss of consciousness 27.89 10.28 453 117373 78922 29755730
Delirium 27.86 10.28 263 117563 40368 29794284
Diabetic neuropathy 27.49 10.28 53 117773 3906 29830746
Myoclonic epilepsy 27.24 10.28 24 117802 802 29833850
Haematuria 27.22 10.28 88 117738 44746 29789906
Mydriasis 26.53 10.28 68 117758 6075 29828577
Oedema peripheral 26.46 10.28 573 117253 105259 29729393
Blood creatinine increased 26.38 10.28 231 117595 91144 29743508
Bradyphrenia 26.29 10.28 52 117774 3905 29830747
Infusion related reaction 25.77 10.28 78 117748 40486 29794166
Pleural effusion 25.70 10.28 178 117648 73888 29760764
Cardio-respiratory arrest 25.60 10.28 127 117699 57179 29777473
Pancytopenia 25.45 10.28 213 117613 84839 29749813
Photosensitivity reaction 25.43 10.28 90 117736 9604 29825048
Drug resistance 25.38 10.28 25 117801 20108 29814544
Ventricular tachycardia 25.36 10.28 34 117792 23828 29810824
Depersonalisation/derealisation disorder 25.17 10.28 19 117807 508 29834144
Product prescribing issue 25.10 10.28 23 117803 810 29833842
Mental impairment 25.09 10.28 87 117739 9190 29825462
Clumsiness 24.91 10.28 29 117797 1358 29833294
Fluid overload 24.90 10.28 23 117803 19069 29815583
Blepharospasm 24.89 10.28 24 117802 902 29833750
Aspergillus infection 24.77 10.28 5 117821 10209 29824443
Coordination abnormal 24.74 10.28 74 117752 7231 29827421
Graft versus host disease 24.55 10.28 5 117821 10145 29824507
Epistaxis 23.90 10.28 117 117709 52864 29781788
Nausea 23.90 10.28 941 116885 296016 29538636
Haemodialysis 23.77 10.28 7 117819 11066 29823586
Hyperpyrexia 23.69 10.28 39 117787 2538 29832114
Thrombocytopenia 23.59 10.28 388 117438 136656 29697996
Urinary retention 23.54 10.28 215 117611 32702 29801950
Aggression 23.39 10.28 235 117591 36672 29797980
Disorientation 23.38 10.28 207 117619 31211 29803441
Chest pain 23.33 10.28 324 117502 117303 29717349
Pulmonary thrombosis 23.16 10.28 66 117760 6277 29828375
Infection 23.15 10.28 196 117630 77878 29756774
Bronchopulmonary aspergillosis 22.58 10.28 10 117816 12274 29822378
Back disorder 22.50 10.28 63 117763 5931 29828721
Lymphadenopathy 21.82 10.28 39 117787 24337 29810315
Haemoglobin decreased 21.67 10.28 317 117509 113781 29720871
Renal failure 21.58 10.28 367 117459 128599 29706053
Head circumference abnormal 21.54 10.28 8 117818 44 29834608
Reading disorder 21.51 10.28 14 117812 293 29834359
Formication 21.49 10.28 30 117796 1687 29832965
Pulmonary hypertension 21.39 10.28 26 117800 19010 29815642
International normalised ratio increased 21.20 10.28 106 117720 47633 29787019
Platelet count decreased 21.16 10.28 292 117534 105837 29728815
Hepatocellular injury 21.16 10.28 172 117654 25299 29809353
Mood altered 21.13 10.28 76 117750 8174 29826478
Hallucination 21.13 10.28 290 117536 48769 29785883
Injection site pain 20.93 10.28 56 117770 30254 29804398
Anger 20.90 10.28 93 117733 11027 29823625
Blood homocysteine increased 20.85 10.28 13 117813 252 29834400
Withdrawal arrhythmia 20.64 10.28 7 117819 28 29834624
Bone marrow failure 20.59 10.28 55 117771 29730 29804922
Pancreatitis 20.53 10.28 74 117752 36416 29798236
Depression 20.51 10.28 483 117343 89954 29744698
Petit mal epilepsy 20.49 10.28 37 117789 2594 29832058
Unevaluable event 20.27 10.28 61 117765 31724 29802928
Persistent depressive disorder 20.19 10.28 13 117813 267 29834385
Ejection fraction decreased 20.12 10.28 18 117808 15157 29819495
White blood cell count increased 20.05 10.28 84 117742 39589 29795063
Irritability 19.88 10.28 157 117669 22893 29811759
Hepatic failure 19.85 10.28 68 117758 33975 29800677
Thermophobia 19.83 10.28 9 117817 88 29834564
Peritonitis bacterial 19.78 10.28 10 117816 11368 29823284
Blood folate decreased 19.62 10.28 16 117810 480 29834172
Leukocytosis 19.61 10.28 34 117792 21468 29813184
Rectal haemorrhage 19.56 10.28 71 117755 34868 29799784
Brain injury 19.55 10.28 57 117769 5491 29829161
Clostridium difficile infection 19.44 10.28 20 117806 15763 29818889
Injection site reaction 19.40 10.28 9 117817 10751 29823901
Accidental poisoning 19.39 10.28 16 117810 488 29834164
Benzodiazepine drug level decreased 19.39 10.28 7 117819 35 29834617
Weight decreased 19.36 10.28 449 117377 150472 29684180
Flushing 19.24 10.28 56 117770 29436 29805216
Facial neuralgia 19.23 10.28 7 117819 36 29834616
Angioedema 19.17 10.28 70 117756 34314 29800338
Rash 19.10 10.28 592 117234 191297 29643355
Upper gastrointestinal haemorrhage 19.04 10.28 36 117790 21992 29812660
Visual acuity reduced 19.02 10.28 117 117709 15729 29818923
Jaundice 18.87 10.28 65 117761 32421 29802231
Sciatica 18.81 10.28 53 117773 5008 29829644
Hallucination, visual 18.73 10.28 118 117708 15995 29818657
Quality of life decreased 18.69 10.28 40 117786 3177 29831475
Polyneuropathy 18.66 10.28 94 117732 11729 29822923
Astigmatism 18.61 10.28 19 117807 766 29833886
Muscle twitching 18.29 10.28 72 117754 8083 29826569
Drug effective for unapproved indication 18.12 10.28 22 117804 1077 29833575
Renal injury 17.98 10.28 12 117814 11717 29822935
Acute kidney injury 17.84 10.28 888 116938 272954 29561698
Posterior reversible encephalopathy syndrome 17.80 10.28 6 117820 8701 29825951
Transplant rejection 17.71 10.28 7 117819 9199 29825453
Intentional self-injury 17.57 10.28 102 117724 13430 29821222
Nephropathy toxic 17.54 10.28 10 117816 10629 29824023
Neuroleptic malignant syndrome 17.53 10.28 23 117803 16272 29818380
Tuberculosis 17.53 10.28 5 117821 8072 29826580
White blood cell count decreased 17.44 10.28 229 117597 83718 29750934
Lymphoma 17.44 10.28 9 117817 10112 29824540
Accessory spleen 17.40 10.28 10 117816 166 29834486
Somatic symptom disorder 17.24 10.28 15 117811 493 29834159
Gamma-glutamyltransferase increased 17.23 10.28 184 117642 29166 29805486
Sinusitis 17.23 10.28 70 117756 33275 29801377
Dialysis 17.20 10.28 11 117815 10985 29823667
Staphylococcal infection 17.20 10.28 61 117765 30163 29804489
Seizure 17.15 10.28 508 117318 97967 29736685
Psychogenic seizure 17.12 10.28 12 117814 285 29834367
Clostridium difficile colitis 17.10 10.28 15 117811 12753 29821899
Drug interaction 16.93 10.28 953 116873 198615 29636037
Electrocardiogram QT prolonged 16.82 10.28 78 117748 35757 29798895
Product substitution 16.79 10.28 6 117820 29 29834623
Generalised tonic-clonic seizure 16.77 10.28 133 117693 19418 29815234
Spinal stenosis 16.74 10.28 46 117780 4283 29830369
Cardiomyopathy 16.68 10.28 21 117805 15122 29819530
Epilepsy 16.65 10.28 136 117690 20033 29814619
Lung infiltration 16.53 10.28 15 117811 12544 29822108
Motor dysfunction 16.53 10.28 56 117770 5846 29828806
Substance use 16.51 10.28 14 117812 444 29834208
Failure to anastomose 16.39 10.28 11 117815 243 29834409
Increased appetite 16.35 10.28 54 117772 5563 29829089
Enterococcal infection 16.25 10.28 6 117820 8218 29826434
Hyperbilirubinaemia 16.18 10.28 26 117800 16916 29817736
Septic shock 16.13 10.28 166 117660 63441 29771211
Red blood cell sedimentation rate increased 16.04 10.28 64 117762 7231 29827421
Limb injury 16.01 10.28 74 117752 8917 29825735
Overweight 16.00 10.28 24 117802 1441 29833211
Stress at work 15.95 10.28 9 117817 144 29834508
Dysaesthesia 15.94 10.28 30 117796 2171 29832481
Abdominal pain 15.91 10.28 409 117417 135245 29699407
Panic attack 15.86 10.28 72 117754 8609 29826043
Body height decreased 15.78 10.28 41 117785 3693 29830959
Vertigo 15.75 10.28 147 117679 22488 29812164
Nystagmus 15.70 10.28 45 117781 4293 29830359
Failure to thrive 15.70 10.28 6 117820 8048 29826604
Personality disorder 15.69 10.28 21 117805 1134 29833518
Ventricular fibrillation 15.65 10.28 22 117804 15116 29819536
Wrong drug 15.64 10.28 7 117819 66 29834586
Haemodynamic instability 15.58 10.28 6 117820 8009 29826643
Loss of personal independence in daily activities 15.56 10.28 141 117685 21394 29813258
Chills 15.52 10.28 196 117630 72142 29762510
Malaise 15.48 10.28 804 117022 166158 29668494
Feeling of body temperature change 15.23 10.28 22 117804 1277 29833375
Abnormal behaviour 15.21 10.28 161 117665 25462 29809190
Peritonitis 15.13 10.28 39 117787 21336 29813316
Wrong technique in product usage process 15.11 10.28 67 117759 31088 29803564
Neck pain 15.07 10.28 137 117689 20807 29813845
Adrenocorticotropic hormone deficiency 15.00 10.28 13 117813 425 29834227
Nerve degeneration 14.97 10.28 9 117817 163 29834489
Alanine aminotransferase increased 14.93 10.28 204 117622 74072 29760580
Spinal pain 14.91 10.28 45 117781 4419 29830233
Leukopenia 14.89 10.28 145 117681 56014 29778638
Product dispensing error 14.87 10.28 54 117772 5835 29828817
Hepatic cirrhosis 14.86 10.28 25 117801 15974 29818678
Deafness 14.85 10.28 80 117746 10245 29824407
Decreased appetite 14.78 10.28 463 117363 149447 29685205
Eosinophilic myocarditis 14.77 10.28 13 117813 434 29834218
Muscular weakness 14.76 10.28 341 117485 63304 29771348
Hypophagia 14.67 10.28 42 117784 22194 29812458
Brain malformation 14.62 10.28 7 117819 78 29834574
Multiple sclerosis 14.59 10.28 62 117764 7205 29827447
Accident 14.58 10.28 39 117787 3574 29831078
Gastrointestinal disorder 14.58 10.28 59 117767 28078 29806574
Disseminated intravascular coagulation 14.53 10.28 42 117784 22129 29812523
Venous oxygen saturation decreased 14.53 10.28 4 117822 6 29834646
Agitation neonatal 14.49 10.28 19 117807 1006 29833646
Gait inability 14.46 10.28 125 117701 18716 29815936
Vomiting 14.46 10.28 712 117114 219106 29615546
Sensory disturbance 14.43 10.28 53 117773 5758 29828894
Pseudomonas infection 14.43 10.28 12 117814 10470 29824182
Haemorrhage subcutaneous 14.39 10.28 29 117797 2208 29832444
Thrombotic microangiopathy 14.33 10.28 8 117818 8602 29826050
Acute pulmonary oedema 14.24 10.28 63 117763 7452 29827200
Acute myeloid leukaemia 14.22 10.28 31 117795 17975 29816677
Back pain 14.18 10.28 515 117311 102081 29732571
Dysgeusia 14.15 10.28 50 117776 24751 29809901
Visual field defect 14.15 10.28 44 117782 4392 29830260
Derealisation 14.03 10.28 14 117812 549 29834103
Behaviour disorder 14.02 10.28 30 117796 2382 29832270
Upper respiratory tract infection 13.99 10.28 58 117768 27418 29807234
Kidney transplant rejection 13.98 10.28 6 117820 7503 29827149
Product dose omission issue 13.97 10.28 265 117561 91366 29743286
Colitis ulcerative 13.93 10.28 22 117804 14412 29820240
Diastolic hypotension 13.85 10.28 5 117821 25 29834627
Testicular necrosis 13.81 10.28 4 117822 8 29834644
Device related infection 13.68 10.28 29 117797 16986 29817666
Complex regional pain syndrome 13.63 10.28 13 117813 482 29834170
Amputee 13.63 10.28 3 117823 0 29834652
Aspartate aminotransferase increased 13.54 10.28 172 117654 63250 29771402
Haemorrhage intracranial 13.50 10.28 24 117802 15008 29819644
Cytomegalovirus viraemia 13.49 10.28 3 117823 5726 29828926
Sleep deficit 13.28 10.28 12 117814 415 29834237
Onychophagia 13.24 10.28 5 117821 29 29834623
Frustration tolerance decreased 13.22 10.28 26 117800 1944 29832708
Pseudolymphoma 13.19 10.28 13 117813 502 29834150
Hypokalaemia 13.13 10.28 130 117696 50062 29784590
Post laminectomy syndrome 13.09 10.28 9 117817 207 29834445
Hypopituitarism 13.08 10.28 23 117803 1579 29833073
Ejaculation delayed 13.05 10.28 9 117817 208 29834444
Torsade de pointes 12.98 10.28 6 117820 7184 29827468
Drug diversion 12.98 10.28 17 117809 899 29833753
Psoriasis 12.91 10.28 106 117720 42400 29792252
Nervous system neoplasm 12.88 10.28 8 117818 154 29834498
Hepatitis C 12.86 10.28 20 117806 13185 29821467
Influenza virus test positive 12.80 10.28 7 117819 105 29834547
Venoocclusive liver disease 12.77 10.28 5 117821 6608 29828044
Preternatural anus 12.74 10.28 7 117819 106 29834546
Hiccups 12.74 10.28 11 117815 9423 29825229
Cellulitis 12.74 10.28 120 117706 46664 29787988
Haematocrit decreased 12.60 10.28 70 117756 30629 29804023
Rash scarlatiniform 12.46 10.28 7 117819 111 29834541
Oedema 12.45 10.28 238 117588 42755 29791897
Sexual activity increased 12.45 10.28 5 117821 35 29834617
Renal impairment 12.36 10.28 245 117581 83939 29750713
Pneumocystis jirovecii pneumonia 12.30 10.28 31 117795 17089 29817563
Injury 12.27 10.28 44 117782 21687 29812965
Haemorrhage 12.20 10.28 119 117707 45960 29788692
Rhabdomyolysis 12.17 10.28 332 117494 63248 29771404
Generalised anxiety disorder 12.15 10.28 14 117812 648 29834004
Haemoptysis 12.15 10.28 72 117754 31006 29803646
Inguinal mass 12.10 10.28 5 117821 38 29834614
Abdominal discomfort 12.10 10.28 128 117698 48663 29785989
Hepatomegaly 12.07 10.28 13 117813 10034 29824618
Depressed mood 12.05 10.28 111 117715 16918 29817734
Therapy cessation 12.01 10.28 26 117800 15111 29819541
Rhinalgia 11.99 10.28 11 117815 388 29834264
Joint swelling 11.98 10.28 255 117571 46691 29787961
Contraindication to medical treatment 11.98 10.28 12 117814 473 29834179
Myocardial ischaemia 11.95 10.28 32 117794 17285 29817367
Mucormycosis 11.93 10.28 3 117823 5265 29829387
Deep vein thrombosis 11.86 10.28 167 117659 60334 29774318
Restless legs syndrome 11.82 10.28 56 117770 6816 29827836
Application site hypersensitivity 11.78 10.28 7 117819 124 29834528
Melaena 11.72 10.28 77 117749 32360 29802292
Libido decreased 11.64 10.28 42 117784 4524 29830128
Injection site erythema 11.62 10.28 23 117803 13811 29820841
Metabolic acidosis 11.57 10.28 93 117733 37368 29797284
Nightmare 11.39 10.28 84 117742 11992 29822660
Dementia 11.37 10.28 86 117740 12375 29822277
Wrong product administered 11.37 10.28 42 117784 4576 29830076
Dehydration 11.35 10.28 385 117441 123154 29711498
Chondrocalcinosis 11.32 10.28 9 117817 260 29834392
Depression suicidal 11.31 10.28 19 117807 1257 29833395
Skull fracture 11.28 10.28 16 117810 913 29833739
Pericardial effusion 11.16 10.28 44 117782 21100 29813552
Dysmetropsia 11.10 10.28 3 117823 4 29834648
Intestinal sepsis 11.09 10.28 11 117815 428 29834224
Joint arthroplasty 11.08 10.28 13 117813 614 29834038
Panic reaction 11.07 10.28 20 117806 1403 29833249
Neonatal hyponatraemia 11.03 10.28 6 117820 89 29834563
Infusion site induration 11.03 10.28 8 117818 201 29834451
Anhedonia 11.01 10.28 10 117816 8359 29826293
Atelectasis 11.00 10.28 30 117796 16108 29818544
Libido increased 10.94 10.28 15 117811 829 29833823
Fatigue 10.92 10.28 1100 116726 319573 29515079
Candida infection 10.90 10.28 28 117798 15334 29819318
Peripheral coldness 10.86 10.28 53 117773 6530 29828122
Human ehrlichiosis 10.86 10.28 8 117818 206 29834446
Vertebral foraminal stenosis 10.67 10.28 12 117814 541 29834111
Peripheral swelling 10.61 10.28 315 117511 60759 29773893
Upper limb fracture 10.59 10.28 38 117788 4082 29830570
Myelosuppression 10.56 10.28 8 117818 7314 29827338
Adverse drug reaction 10.50 10.28 51 117775 23094 29811558
Multiple fractures 10.49 10.28 19 117807 1335 29833317
Lipoma 10.48 10.28 20 117806 1463 29833189
Small intestinal obstruction 10.39 10.28 24 117802 13635 29821017
Ejaculation disorder 10.38 10.28 16 117810 984 29833668
Pneumothorax 10.38 10.28 31 117795 16162 29818490
Homicidal ideation 10.36 10.28 27 117799 2436 29832216
Vibratory sense increased 10.35 10.28 3 117823 6 29834646
Varicose ulceration 10.35 10.28 3 117823 6 29834646
Haemolysis 10.30 10.28 8 117818 7223 29827429

Pharmacologic Action:

SourceCodeDescription
ATC N03AX16 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Other antiepileptics
MeSH PA D000700 Analgesics
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D000927 Anticonvulsants
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018689 Sensory System Agents
MeSH PA D014149 Tranquilizing Agents
CHEBI has role CHEBI:35623 antiepileptic
CHEBI has role CHEBI:38215 calcium channel blockers

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Postherpetic neuralgia indication 2177002
Generalized anxiety disorder indication 21897009 DOID:14320
Fibromyalgia indication 203082005 DOID:631
Diabetic peripheral neuropathy indication 424736006
Partial Epilepsy Treatment Adjunct indication
Suicidal thoughts contraindication 6471006
Weight gain finding contraindication 8943002
Reduced visual acuity contraindication 13164000
Depressive disorder contraindication 35489007
Angioedema contraindication 41291007 DOID:1558
Chronic heart failure contraindication 48447003
Disorder of muscle contraindication 129565002 DOID:423
Decompensated cardiac failure contraindication 195111005
Impaired renal function disorder contraindication 197663003
Atrioventricular block contraindication 233917008 DOID:0050820
Rhabdomyolysis contraindication 240131006
Drowsy contraindication 271782001
Peripheral edema contraindication 271809000
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Dizziness contraindication 404640003

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.97 acidic
pKa2 10.4 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
165MG LYRICA CR UPJOHN N209501 Oct. 11, 2017 RX TABLET, EXTENDED RELEASE ORAL April 11, 2021 PEDIATRIC EXCLUSIVITY
330MG LYRICA CR UPJOHN N209501 Oct. 11, 2017 RX TABLET, EXTENDED RELEASE ORAL April 11, 2021 PEDIATRIC EXCLUSIVITY
82.5MG LYRICA CR UPJOHN N209501 Oct. 11, 2017 RX TABLET, EXTENDED RELEASE ORAL April 11, 2021 PEDIATRIC EXCLUSIVITY
100MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL May 3, 2021 NEW PATIENT POPULATION
150MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL May 3, 2021 NEW PATIENT POPULATION
200MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL May 3, 2021 NEW PATIENT POPULATION
225MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL May 3, 2021 NEW PATIENT POPULATION
25MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL May 3, 2021 NEW PATIENT POPULATION
300MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL May 3, 2021 NEW PATIENT POPULATION
50MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL May 3, 2021 NEW PATIENT POPULATION
75MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL May 3, 2021 NEW PATIENT POPULATION
20MG/ML LYRICA UPJOHN N022488 Jan. 4, 2010 RX SOLUTION ORAL May 3, 2021 NEW PATIENT POPULATION
100MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL Nov. 3, 2021 PEDIATRIC EXCLUSIVITY
150MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL Nov. 3, 2021 PEDIATRIC EXCLUSIVITY
200MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL Nov. 3, 2021 PEDIATRIC EXCLUSIVITY
225MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL Nov. 3, 2021 PEDIATRIC EXCLUSIVITY
25MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL Nov. 3, 2021 PEDIATRIC EXCLUSIVITY
300MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL Nov. 3, 2021 PEDIATRIC EXCLUSIVITY
50MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL Nov. 3, 2021 PEDIATRIC EXCLUSIVITY
75MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL Nov. 3, 2021 PEDIATRIC EXCLUSIVITY
20MG/ML LYRICA UPJOHN N022488 Jan. 4, 2010 RX SOLUTION ORAL Nov. 3, 2021 PEDIATRIC EXCLUSIVITY
100MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL May 23, 2022 NEW PATIENT POPULATION
150MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL May 23, 2022 NEW PATIENT POPULATION
200MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL May 23, 2022 NEW PATIENT POPULATION
225MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL May 23, 2022 NEW PATIENT POPULATION
25MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL May 23, 2022 NEW PATIENT POPULATION
300MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL May 23, 2022 NEW PATIENT POPULATION
50MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL May 23, 2022 NEW PATIENT POPULATION
75MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL May 23, 2022 NEW PATIENT POPULATION
20MG/ML LYRICA UPJOHN N022488 Jan. 4, 2010 RX SOLUTION ORAL May 23, 2022 NEW PATIENT POPULATION
100MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL Nov. 23, 2022 PEDIATRIC EXCLUSIVITY
150MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL Nov. 23, 2022 PEDIATRIC EXCLUSIVITY
200MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL Nov. 23, 2022 PEDIATRIC EXCLUSIVITY
225MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL Nov. 23, 2022 PEDIATRIC EXCLUSIVITY
25MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL Nov. 23, 2022 PEDIATRIC EXCLUSIVITY
300MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL Nov. 23, 2022 PEDIATRIC EXCLUSIVITY
50MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL Nov. 23, 2022 PEDIATRIC EXCLUSIVITY
75MG LYRICA UPJOHN N021446 Dec. 30, 2004 RX CAPSULE ORAL Nov. 23, 2022 PEDIATRIC EXCLUSIVITY
20MG/ML LYRICA UPJOHN N022488 Jan. 4, 2010 RX SOLUTION ORAL Nov. 23, 2022 PEDIATRIC EXCLUSIVITY

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-dependent calcium channel subunit alpha-2/delta-1 Ion channel MODULATOR IC50 7.10 WOMBAT-PK CHEMBL
Voltage-dependent calcium channel subunit alpha-2/delta-2 Ion channel MODULATOR IC50 7.26 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Large neutral amino acids transporter small subunit 1 Transporter IC50 3.80 WOMBAT-PK
Uncharacterized protein; Voltage-dependent calcium channel alpha-2 delta subunit Ion channel IC50 7.14 CHEMBL

External reference:

IDSource
4024924 VUID
N0000171595 NUI
D02716 KEGG_DRUG
4024924 VANDF
C0657912 UMLSCUI
CHEBI:64356 CHEBI
5486971 PUBCHEM_CID
CHEMBL1059 ChEMBL_ID
D000069583 MESH_DESCRIPTOR_UI
DB00230 DRUGBANK_ID
5484 IUPHAR_LIGAND_ID
7643 INN_ID
55JG375S6M UNII
187832 RXNORM
19649 MMSL
67412 MMSL
79550 MMSL
d05508 MMSL
010083 NDDF
415159003 SNOMEDCT_US
415160008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lyrica HUMAN PRESCRIPTION DRUG LABEL 1 0071-1012 CAPSULE 25 mg ORAL NDA 33 sections
Lyrica HUMAN PRESCRIPTION DRUG LABEL 1 0071-1013 CAPSULE 50 mg ORAL NDA 33 sections
Lyrica HUMAN PRESCRIPTION DRUG LABEL 1 0071-1014 CAPSULE 75 mg ORAL NDA 33 sections
Lyrica HUMAN PRESCRIPTION DRUG LABEL 1 0071-1015 CAPSULE 100 mg ORAL NDA 33 sections
Lyrica HUMAN PRESCRIPTION DRUG LABEL 1 0071-1016 CAPSULE 150 mg ORAL NDA 33 sections
Lyrica HUMAN PRESCRIPTION DRUG LABEL 1 0071-1017 CAPSULE 200 mg ORAL NDA 33 sections
Lyrica HUMAN PRESCRIPTION DRUG LABEL 1 0071-1018 CAPSULE 300 mg ORAL NDA 33 sections
Lyrica HUMAN PRESCRIPTION DRUG LABEL 1 0071-1019 CAPSULE 225 mg ORAL NDA 33 sections
Lyrica HUMAN PRESCRIPTION DRUG LABEL 1 0071-1020 SOLUTION 20 mg ORAL NDA 33 sections
Lyrica CR HUMAN PRESCRIPTION DRUG LABEL 1 0071-1026 TABLET, FILM COATED, EXTENDED RELEASE 82.50 mg ORAL NDA 33 sections
Lyrica CR HUMAN PRESCRIPTION DRUG LABEL 1 0071-1027 TABLET, FILM COATED, EXTENDED RELEASE 165 mg ORAL NDA 33 sections
Lyrica CR HUMAN PRESCRIPTION DRUG LABEL 1 0071-1029 TABLET, FILM COATED, EXTENDED RELEASE 330 mg ORAL NDA 33 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0093-7621 CAPSULE 300 mg ORAL ANDA 28 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0093-7624 CAPSULE 75 mg ORAL ANDA 28 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0093-7625 CAPSULE 100 mg ORAL ANDA 28 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0093-7626 CAPSULE 150 mg ORAL ANDA 28 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0093-7627 CAPSULE 200 mg ORAL ANDA 28 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0093-7628 CAPSULE 225 mg ORAL ANDA 28 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0228-2856 CAPSULE 25 mg ORAL ANDA 29 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0228-2857 CAPSULE 50 mg ORAL ANDA 29 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0228-2858 CAPSULE 75 mg ORAL ANDA 29 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0228-2859 CAPSULE 100 mg ORAL ANDA 29 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0228-2860 CAPSULE 150 mg ORAL ANDA 29 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0228-2861 CAPSULE 200 mg ORAL ANDA 29 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0228-2862 CAPSULE 225 mg ORAL ANDA 29 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0228-2863 CAPSULE 300 mg ORAL ANDA 29 sections
PREGABALIN HUMAN PRESCRIPTION DRUG LABEL 1 0904-6991 CAPSULE 25 mg ORAL ANDA 19 sections
PREGABALIN HUMAN PRESCRIPTION DRUG LABEL 1 0904-6992 CAPSULE 50 mg ORAL ANDA 19 sections
PREGABALIN HUMAN PRESCRIPTION DRUG LABEL 1 0904-7000 CAPSULE 75 mg ORAL ANDA 19 sections
PREGABALIN HUMAN PRESCRIPTION DRUG LABEL 1 0904-7001 CAPSULE 100 mg ORAL ANDA 19 sections