pregabalin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
gabamimetic agents 2255 148553-50-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pregabalin
  • (S)-Pregabalin
  • gabanext
  • maxgalin
  • lyrica
  • pregabalin hydrochloride
  • pregabalin HCl
A gamma-aminobutyric acid (GABA) derivative that functions as a CALCIUM CHANNEL BLOCKER and is used as an ANTICONVULSANT as well as an ANTI-ANXIETY AGENT. It is also used as an ANALGESIC in the treatment of NEUROPATHIC PAIN and FIBROMYALGIA.
  • Molecular weight: 159.23
  • Formula: C8H17NO2
  • CLOGP: -0.92
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 63.32
  • ALOGS: -1.15
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.30 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 11.30 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 90 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 53.83 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 90 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
July 6, 2004 EMA
Dec. 30, 2004 FDA PF PRISM CV

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Withdrawal syndrome 1580.57 9.92 1073 314538 18924 63154487
Somnolence 1286.92 9.92 2781 312830 175904 62997507
Intentional product misuse 627.91 9.92 1104 314507 59813 63113598
Feeling abnormal 566.79 9.92 1824 313787 146568 63026843
Pemphigus 506.11 9.92 143 315468 183583 62989828
Maternal exposure during pregnancy 425.30 9.92 286 315325 219776 62953635
Glossodynia 394.56 9.92 198 315413 178678 62994733
Weight increased 380.77 9.92 2407 313204 258385 62915026
Drug dependence 362.94 9.92 524 315087 23959 63149452
Systemic lupus erythematosus 359.48 9.92 306 315305 208612 62964799
Pain 354.75 9.92 5400 310211 735228 62438183
Alopecia 350.22 9.92 720 314891 336816 62836595
Drug hypersensitivity 332.56 9.92 2660 312951 308027 62865384
Memory impairment 330.71 9.92 1205 314406 103053 63070358
Dizziness 330.57 9.92 3426 312185 426499 62746912
Hand deformity 321.98 9.92 197 315414 159260 63014151
Gait disturbance 315.51 9.92 1766 313845 181412 62991999
Anti-cyclic citrullinated peptide antibody positive 297.45 9.92 103 315508 116109 63057302
Abdominal discomfort 287.94 9.92 740 314871 320145 62853266
Insomnia 286.72 9.92 1942 313669 213310 62960101
Vision blurred 285.24 9.92 1055 314556 90869 63082542
Drug withdrawal syndrome 282.86 9.92 495 315116 26699 63146712
Therapeutic product effect incomplete 279.95 9.92 1298 314313 123758 63049653
Exposure during pregnancy 275.94 9.92 221 315390 155326 63018085
Tremor 269.57 9.92 1336 314275 130903 63042508
Sciatica 259.92 9.92 546 315065 33778 63139633
Fall 258.43 9.92 3033 312578 389301 62784110
Drug abuse 250.37 9.92 862 314749 71656 63101755
Pericarditis 250.05 9.92 174 315437 131405 63042006
Disturbance in attention 225.10 9.92 550 315061 37639 63135772
Neuralgia 211.13 9.92 425 315186 25501 63147910
Feeling drunk 209.49 9.92 170 315441 3972 63169439
Suicidal ideation 207.67 9.92 733 314878 61688 63111723
Thinking abnormal 205.34 9.92 259 315352 10384 63163027
Hypoacusis 205.20 9.92 403 315208 23748 63149663
Speech disorder 204.15 9.92 551 315060 40078 63133333
Wound 202.68 9.92 311 315300 162952 63010459
Pain in extremity 196.54 9.92 2513 313098 328973 62844438
Death 193.23 9.92 1082 314529 373299 62800112
Prescribed overdose 191.92 9.92 483 315128 33670 63139741
Confusional state 185.54 9.92 1893 313718 234487 62938924
Impaired driving ability 182.78 9.92 163 315448 4348 63169063
Euphoric mood 177.34 9.92 166 315445 4721 63168690
Sopor 176.52 9.92 360 315251 21804 63151607
Infusion related reaction 170.49 9.92 636 314975 244885 62928526
Burning sensation 168.33 9.92 624 314987 53783 63119628
Coma 157.37 9.92 686 314925 63678 63109733
Pre-existing condition improved 154.90 9.92 198 315413 8046 63165365
Malaise 154.24 9.92 2913 312698 413041 62760370
Body height decreased 154.19 9.92 219 315392 9859 63163552
Impaired work ability 150.16 9.92 293 315318 17182 63156229
Myoclonus 148.62 9.92 276 315335 15592 63157819
Sleep disorder 139.96 9.92 786 314825 80780 63092631
Macular degeneration 138.28 9.92 346 315265 24030 63149381
Device expulsion 138.01 9.92 9 315602 34913 63138498
Therapeutic response unexpected 134.62 9.92 292 315319 18467 63154944
Arthropathy 131.89 9.92 659 314952 234133 62939278
Hypoaesthesia 130.79 9.92 1346 314265 167047 63006364
Hepatic enzyme increased 129.04 9.92 542 315069 201786 62971625
Discomfort 125.87 9.92 419 315192 166955 63006456
Product dispensing error 125.04 9.92 201 315410 10104 63163307
Synovitis 123.39 9.92 494 315117 186424 62986987
Stomatitis 121.84 9.92 323 315288 138402 63035009
Injection site pain 121.13 9.92 293 315318 129507 63043904
Movement disorder 120.29 9.92 305 315306 21356 63152055
Disorientation 119.96 9.92 450 315161 39002 63134409
Balance disorder 119.64 9.92 774 314837 83648 63089763
Febrile neutropenia 118.10 9.92 258 315353 118191 63055220
Depressed level of consciousness 115.09 9.92 611 315000 61467 63111944
Overdose 114.52 9.92 970 314641 114108 63059303
Duodenal ulcer perforation 113.17 9.92 161 315450 87048 63086363
Hypersensitivity 112.81 9.92 922 314689 291763 62881648
Contraindicated product administered 112.66 9.92 628 314983 217020 62956391
Dysarthria 109.61 9.92 462 315149 42249 63131162
Dyskinesia 107.44 9.92 377 315234 31625 63141786
Depression 107.22 9.92 1468 314143 195024 62978387
Amnesia 107.11 9.92 553 315058 55032 63118379
Muscle twitching 105.15 9.92 273 315338 19395 63154016
Visual impairment 104.62 9.92 749 314862 83697 63089714
Dysstasia 104.26 9.92 285 315326 20881 63152530
Impaired healing 102.51 9.92 223 315388 102319 63071092
Anxiety 101.25 9.92 1581 314030 215960 62957451
Intentional product use issue 99.13 9.92 1022 314589 126870 63046541
Premature delivery 98.69 9.92 16 315595 30265 63143146
Crying 94.48 9.92 293 315318 23050 63150361
Lower respiratory tract infection 94.20 9.92 339 315272 131968 63041443
Hyperhidrosis 93.44 9.92 882 314729 106954 63066457
Respiratory depression 93.33 9.92 209 315402 13506 63159905
Diarrhoea 93.10 9.92 2778 312833 712588 62460823
Mental impairment 91.15 9.92 211 315400 13940 63159471
Vertigo 91.01 9.92 559 315052 59328 63114083
Prescription drug used without a prescription 90.35 9.92 83 315528 2303 63171108
Helicobacter infection 90.11 9.92 205 315406 92580 63080831
Folliculitis 90.06 9.92 131 315480 70186 63103225
Injection site erythema 89.83 9.92 173 315438 83001 63090410
Product prescribing error 89.37 9.92 311 315300 25978 63147433
Dry mouth 88.69 9.92 677 314934 77186 63096225
Expired product administered 86.82 9.92 129 315482 6052 63167359
Restlessness 86.28 9.92 332 315279 29121 63144290
Loss of consciousness 85.48 9.92 931 314680 117190 63056221
Irritability 84.59 9.92 347 315264 31347 63142064
Altered state of consciousness 82.78 9.92 295 315316 24935 63148476
Oedema peripheral 82.42 9.92 1362 314249 188149 62985262
International normalised ratio fluctuation 82 9.92 80 315531 2398 63171013
Diplopia 80.92 9.92 281 315330 23447 63149964
Muscle injury 80.52 9.92 125 315486 65220 63108191
Injection site swelling 78.91 9.92 72 315539 47500 63125911
Neutropenia 78.49 9.92 528 315083 174477 62998934
Gait inability 78.38 9.92 491 315120 52468 63120943
Ill-defined disorder 77.48 9.92 183 315428 81572 63091839
Nervousness 77.09 9.92 332 315279 30647 63142764
Hallucination 76.07 9.92 500 315111 54317 63119094
Rheumatoid factor positive 76.02 9.92 194 315417 84212 63089199
Fibromyalgia 73.81 9.92 666 314945 79754 63093657
Irritable bowel syndrome 73.77 9.92 190 315421 82222 63091189
Therapeutic product effect decreased 73.71 9.92 610 315001 192577 62980834
Gastrointestinal haemorrhage 73.55 9.92 186 315425 80990 63092421
Haemoglobin decreased 71.36 9.92 427 315184 145058 63028353
Fatigue 70.75 9.92 3653 311958 884375 62289036
Pneumonia aspiration 68.89 9.92 347 315264 34193 63139218
Loss of personal independence in daily activities 67.27 9.92 760 314851 96530 63076881
Cognitive disorder 66.21 9.92 490 315121 55325 63118086
Road traffic accident 66.15 9.92 358 315253 36274 63137137
Coordination abnormal 65.40 9.92 183 315428 13590 63159821
Bloody discharge 64.74 9.92 57 315554 1494 63171917
Hospitalisation 64.60 9.92 212 315399 84869 63088542
Dysgraphia 64.22 9.92 80 315531 3166 63170245
Back disorder 64.19 9.92 158 315453 10859 63162552
Miosis 64.03 9.92 124 315487 7229 63166182
Muscle spasms 63.77 9.92 1111 314500 155039 63018372
Intentional overdose 62.97 9.92 604 315007 73548 63099863
Drug ineffective for unapproved indication 60.90 9.92 332 315279 33731 63139680
Sensitivity to weather change 60.54 9.92 120 315491 7117 63166294
Agitation 59.56 9.92 504 315107 59253 63114158
Injection site reaction 57.88 9.92 128 315483 58396 63115015
Suicide attempt 57.17 9.92 507 315104 60411 63113000
Foetal exposure during pregnancy 57.14 9.92 45 315566 31917 63141494
Swelling 56.71 9.92 995 314616 274383 62899028
Illness 56.66 9.92 428 315183 48631 63124780
Hallucination, visual 56.08 9.92 217 315394 19081 63154330
Premature baby 55.45 9.92 17 315594 20718 63152693
Hyperaesthesia 55.36 9.92 135 315476 9223 63164188
Poor quality sleep 54.57 9.92 220 315391 19715 63153696
Drug effective for unapproved indication 54.28 9.92 75 315536 3289 63170122
Rash 53.75 9.92 2261 313350 558610 62614801
Intervertebral disc protrusion 53.64 9.92 247 315364 23462 63149949
Sleep disorder due to general medical condition, insomnia type 53.47 9.92 112 315499 52105 63121306
Pancytopenia 53.25 9.92 274 315337 96659 63076752
Sedation 53.24 9.92 353 315258 38456 63134955
Increased appetite 52.85 9.92 135 315476 9495 63163916
Lyme disease 52.83 9.92 75 315536 3374 63170037
Urinary retention 52.61 9.92 293 315318 30008 63143403
Dysphemia 51.44 9.92 65 315546 2610 63170801
Multiple organ dysfunction syndrome 51.43 9.92 130 315481 56622 63116789
Platelet count decreased 51.22 9.92 352 315259 115770 63057641
Multiple sclerosis 50.12 9.92 247 315364 24125 63149286
Blister 49.89 9.92 409 315202 129405 63044006
Intentional self-injury 49.09 9.92 255 315356 25432 63147979
Pyrexia 49.05 9.92 1878 313733 468600 62704811
Blood iron abnormal 48.95 9.92 77 315534 3799 63169612
Rheumatoid factor negative 48.76 9.92 33 315578 578 63172833
Formication 48.41 9.92 81 315530 4210 63169201
White blood cell count decreased 48.27 9.92 450 315161 138654 63034757
Dependence 47.33 9.92 55 315556 2022 63171389
Muscular weakness 46.56 9.92 861 314750 121492 63051919
Allodynia 46.54 9.92 36 315575 783 63172628
Cytomegalovirus infection 46.43 9.92 23 315588 20929 63152482
Nerve injury 46.10 9.92 131 315480 9815 63163596
Accidental exposure to product 46.02 9.92 41 315570 27364 63146047
Coronary artery disease 45.85 9.92 56 315555 32321 63141090
Cataract 45.64 9.92 459 315152 56594 63116817
Delirium 45.57 9.92 417 315194 50124 63123287
Hepatotoxicity 45.49 9.92 71 315540 36970 63136441
Acute myocardial infarction 45.03 9.92 56 315555 32068 63141343
Drug interaction 44.95 9.92 1473 314138 227658 62945753
Pregnancy 44.87 9.92 71 315540 36765 63136646
Aggression 44.71 9.92 233 315378 23265 63150146
Breakthrough pain 44.59 9.92 42 315569 1204 63172207
Joint swelling 44.52 9.92 1264 314347 326402 62847009
Dyspnoea 44.35 9.92 2765 312846 658548 62514863
Sepsis 44.29 9.92 517 315094 152606 63020805
Bradyphrenia 43.77 9.92 103 315508 6877 63166534
Neoplasm progression 43.63 9.92 71 315540 36357 63137054
Injection site pruritus 43.53 9.92 100 315511 45016 63128395
Wrong technique in product usage process 43.51 9.92 161 315450 62179 63111232
International normalised ratio increased 43.12 9.92 105 315506 46320 63127091
Paraesthesia 42.13 9.92 1050 314561 155916 63017495
Septic shock 42.10 9.92 179 315432 66450 63106961
Pulmonary hypertension 42.03 9.92 75 315536 37048 63136363
Bone erosion 41.50 9.92 18 315593 17699 63155712
Cough 40.86 9.92 1125 314486 291618 62881793
Anaemia 40.09 9.92 1131 314480 292299 62881112
Gastrointestinal disorder 39.96 9.92 438 315173 130801 63042610
Nightmare 39.81 9.92 195 315416 18999 63154412
Trigeminal neuralgia 39.13 9.92 66 315545 3453 63169958
Product dose omission issue 39.04 9.92 877 314734 233436 62939975
Injection site bruising 38.76 9.92 95 315516 41815 63131596
Ataxia 38.69 9.92 164 315447 15031 63158380
Pleural effusion 38.45 9.92 288 315323 92922 63080489
Cardiac failure congestive 38.42 9.92 285 315326 92148 63081263
Mucosal inflammation 38.40 9.92 113 315498 46815 63126596
Haematocrit decreased 38.11 9.92 87 315524 39253 63134158
Multiple sclerosis relapse 37.81 9.92 388 315223 48090 63125321
Affective disorder 37.79 9.92 90 315521 6056 63167355
Bedridden 37.79 9.92 131 315480 10920 63162491
Limb discomfort 36.45 9.92 263 315348 29453 63143958
Hypomagnesaemia 36.33 9.92 54 315557 28683 63144728
Emotional disorder 36.11 9.92 147 315464 13232 63160179
Synovial fluid analysis 35.94 9.92 52 315559 2381 63171030
Ventricular tachycardia 35.88 9.92 28 315583 19951 63153460
Panic reaction 35.87 9.92 70 315541 4104 63169307
Neutrophil count decreased 35.35 9.92 152 315459 56254 63117157
Visual acuity reduced 35.23 9.92 207 315404 21619 63151792
Systemic infection 35.11 9.92 74 315537 4586 63168825
Drug use disorder 35.09 9.92 77 315534 4907 63168504
Body tinea 34.98 9.92 45 315566 1840 63171571
Panic attack 34.90 9.92 210 315401 22121 63151290
Diabetic neuropathy 34.70 9.92 67 315544 3897 63169514
Condition aggravated 34.34 9.92 2380 313231 399837 62773574
Oedema 34.07 9.92 678 314933 96944 63076467
Depressed mood 33.92 9.92 327 315284 39864 63133547
Torsade de pointes 33.85 9.92 12 315599 13339 63160072
Tenosynovitis stenosans 33.38 9.92 60 315551 3304 63170107
Ankle fracture 33.25 9.92 176 315435 17679 63155732
Injection site warmth 33.19 9.92 17 315594 15178 63158233
Intervertebral disc disorder 33.17 9.92 74 315537 4769 63168642
Pruritus 33.10 9.92 1464 314147 359989 62813422
Anger 32.94 9.92 136 315475 12320 63161091
Restless legs syndrome 32.71 9.92 180 315431 18351 63155060
Spinal stenosis 32.67 9.92 154 315457 14771 63158640
Feeling of body temperature change 32.62 9.92 74 315537 4823 63168588
Abnormal behaviour 32.54 9.92 200 315411 21226 63152185
Dysaesthesia 32.46 9.92 70 315541 4408 63169003
Central obesity 32.39 9.92 35 315576 1186 63172225
Frustration tolerance decreased 32.35 9.92 92 315519 6896 63166515
Hostility 32.12 9.92 43 315568 1829 63171582
Premature labour 32.11 9.92 11 315600 12493 63160918
Tension 31.98 9.92 57 315554 3118 63170293
Paralysis 31.83 9.92 115 315496 9785 63163626
Spinal disorder 31.81 9.92 115 315496 9787 63163624
Injection site haemorrhage 31.42 9.92 45 315566 24269 63149142
Atrial fibrillation 31.37 9.92 400 315211 116236 63057175
Libido increased 31.29 9.92 36 315575 1309 63172102
Full blood count decreased 30.91 9.92 51 315560 25973 63147438
Hip arthroplasty 30.72 9.92 127 315484 47519 63125892
Red blood cell sedimentation rate abnormal 30.42 9.92 32 315579 19750 63153661
Abnormal dreams 30.35 9.92 118 315493 10398 63163013
C-reactive protein abnormal 30.26 9.92 122 315489 45974 63127437
Tenderness 30.14 9.92 204 315407 22374 63151037
Knee arthroplasty 29.89 9.92 153 315458 54053 63119358
Ascites 29.87 9.92 103 315508 40625 63132786
Hyperprolactinaemia 29.47 9.92 62 315549 3838 63169573
Hypervolaemia 29.04 9.92 61 315550 28352 63145059
Epistaxis 28.91 9.92 227 315384 72498 63100913
Urticaria 28.63 9.92 617 314994 165185 63008226
Device difficult to use 28.42 9.92 14 315597 12782 63160629
Disease progression 28.38 9.92 434 315177 122324 63051087
Hypersomnia 28.35 9.92 170 315441 17885 63155526
Hypotension 28.15 9.92 1089 314522 271515 62901896
Drug resistance 28.12 9.92 44 315567 22889 63150522
Infective pulmonary exacerbation of cystic fibrosis 27.98 9.92 5 315606 8812 63164599
Caesarean section 27.98 9.92 26 315585 17006 63156405
Mood altered 27.92 9.92 146 315465 14597 63158814
Musculoskeletal pain 27.71 9.92 627 314984 91650 63081761
Full blood count abnormal 27.70 9.92 74 315537 31643 63141768
Therapy cessation 27.41 9.92 70 315541 30387 63143024
Device dislocation 27.28 9.92 54 315557 25651 63147760
Pre-eclampsia 27.26 9.92 6 315605 9127 63164284
Inhibitory drug interaction 27.24 9.92 50 315561 2799 63170612
Photophobia 27.02 9.92 165 315446 17470 63155941
Dysuria 26.77 9.92 271 315340 33467 63139944
Behaviour disorder 26.71 9.92 53 315558 3146 63170265
Fungal infection 26.54 9.92 94 315517 36780 63136631
Thrombocytopenia 26.53 9.92 561 315050 150596 63022815
Visual field defect 26.22 9.92 82 315529 6479 63166932
Gangrene 25.84 9.92 78 315533 6045 63167366
Telangiectasia congenital 25.76 9.92 8 315603 16 63173395
Hypokinesia 25.70 9.92 137 315474 13799 63159612
Renal failure 25.50 9.92 421 315190 117231 63056180
Personality disorder 25.45 9.92 75 315536 5736 63167675
Chest pain 25.40 9.92 849 314762 215110 62958301
Ejection fraction decreased 25.39 9.92 45 315566 22287 63151124
Left ventricular dysfunction 25.32 9.92 14 315597 11974 63161437
Productive cough 25.26 9.92 197 315414 63011 63110400
Blood calcium decreased 25.22 9.92 59 315552 26392 63147019
Pulmonary arterial hypertension 25.21 9.92 46 315565 22531 63150880
Arthralgia 25.11 9.92 2465 313146 567245 62606166
Adverse drug reaction 25.07 9.92 264 315347 79450 63093961
Myelosuppression 24.98 9.92 50 315561 23653 63149758
Labelled drug-drug interaction medication error 24.90 9.92 132 315479 13267 63160144
Therapy non-responder 24.85 9.92 249 315362 75652 63097759
Apathy 24.83 9.92 98 315513 8696 63164715
Body temperature increased 24.69 9.92 98 315513 37094 63136317
Crepitations 24.67 9.92 92 315519 7948 63165463
Middle insomnia 24.49 9.92 126 315485 12517 63160894
Device issue 24.35 9.92 51 315560 23730 63149681
Chest discomfort 24.34 9.92 392 315219 109577 63063834
Thirst decreased 24.26 9.92 16 315595 268 63173143
Antinuclear antibody positive 24.11 9.92 91 315520 7908 63165503
Eye disorder 24.03 9.92 194 315417 22491 63150920
Acute myeloid leukaemia 23.92 9.92 30 315581 17117 63156294
Live birth 23.77 9.92 58 315553 25572 63147839
Aspartate aminotransferase increased 23.75 9.92 311 315300 89966 63083445
Coagulopathy 23.71 9.92 41 315570 20503 63152908
Glaucoma 23.58 9.92 168 315443 18737 63154674
Electrocardiogram QT prolonged 23.58 9.92 186 315425 59344 63114067
Dementia 23.43 9.92 167 315444 18627 63154784
Reading disorder 23.26 9.92 25 315586 842 63172569
Nasopharyngitis 23.21 9.92 1030 314581 253227 62920184
Scleritis 23.19 9.92 61 315550 4367 63169044
Pneumocystis jirovecii pneumonia 23.17 9.92 30 315581 16884 63156527
Monoplegia 23.16 9.92 50 315561 3151 63170260
Injection site rash 23.15 9.92 36 315575 18773 63154638
Parkinsonism 23.06 9.92 108 315503 10331 63163080
Hepatic cirrhosis 22.92 9.92 56 315555 24678 63148733
Anorgasmia 22.88 9.92 21 315590 582 63172829
Product quality issue 22.87 9.92 96 315515 35769 63137642
Pericardial effusion 22.73 9.92 75 315536 29983 63143428
Leukopenia 22.71 9.92 260 315351 77030 63096381
Sensory loss 22.67 9.92 106 315505 10132 63163279
Therapy interrupted 22.52 9.92 84 315527 32371 63141040
Inadequate analgesia 22.48 9.92 47 315564 2896 63170515
Foetal growth restriction 22.47 9.92 5 315606 7548 63165863
Aphasia 22.43 9.92 257 315354 32743 63140668
Complication associated with device 22.36 9.92 31 315580 16947 63156464
Multiple allergies 22.34 9.92 131 315480 13671 63159740
Eosinophilic colitis 22.22 9.92 13 315598 174 63173237
Fracture 22.13 9.92 170 315441 19414 63153997
Tissue infiltration 22.12 9.92 21 315590 608 63172803
Right ventricular failure 22.02 9.92 32 315579 17156 63156255
Normal newborn 22.01 9.92 7 315604 8334 63165077
Substance abuse 21.97 9.92 63 315548 4744 63168667
Psoriatic arthropathy 21.87 9.92 603 315008 90917 63082494
Foaming at mouth 21.86 9.92 28 315583 1140 63172271
Total lung capacity decreased 21.74 9.92 39 315572 2144 63171267
Skull fracture 21.68 9.92 27 315584 1068 63172343
Sensory disturbance 21.64 9.92 129 315482 13543 63159868
Dissociation 21.59 9.92 46 315565 2873 63170538
Sinusitis 21.55 9.92 914 314697 225739 62947672
Seizure 21.37 9.92 834 314777 131800 63041611
Drug screen false positive 21.14 9.92 24 315587 860 63172551
Drug screen positive 21.09 9.92 52 315559 3577 63169834
Vomiting 20.94 9.92 2449 313162 557168 62616243
Feeling jittery 20.92 9.92 126 315485 13277 63160134
Body mass index increased 20.90 9.92 28 315583 1192 63172219
Ventricular fibrillation 20.84 9.92 17 315594 11850 63161561
Retinitis 20.82 9.92 3 315608 6193 63167218
Bradypnoea 20.77 9.92 51 315560 3499 63169912
Flushing 20.75 9.92 256 315355 74831 63098580
Temperature intolerance 20.73 9.92 94 315517 8870 63164541
Neuropathy peripheral 20.55 9.92 724 314887 112943 63060468
Blood creatinine increased 20.49 9.92 310 315301 87534 63085877
Unintentional medical device removal 20.45 9.92 3 315608 6112 63167299
Cervix neoplasm 20.44 9.92 13 315598 204 63173207
Hospice care 20.33 9.92 7 315604 7925 63165486
Negative thoughts 20.21 9.92 24 315587 903 63172508
Nasal polyps 20.11 9.92 3 315608 6036 63167375
Somnambulism 20.09 9.92 67 315544 5476 63167935
Defaecation disorder 20.04 9.92 22 315589 759 63172652
Motor dysfunction 19.99 9.92 106 315505 10655 63162756
Infection susceptibility increased 19.99 9.92 50 315561 3471 63169940
Uterine perforation 19.94 9.92 5 315606 6958 63166453
Limb injury 19.91 9.92 204 315407 25273 63148138
Amnestic disorder 19.88 9.92 15 315596 314 63173097
Deep vein thrombosis 19.80 9.92 295 315316 83505 63089906
Myelodysplastic syndrome 19.74 9.92 33 315578 16721 63156690
Acute respiratory distress syndrome 19.74 9.92 56 315555 23478 63149933
Purpura 19.70 9.92 110 315501 11275 63162136
Back pain 19.62 9.92 1546 314065 262599 62910812
Nervous system disorder 19.61 9.92 160 315451 18606 63154805
Spinal pain 19.55 9.92 122 315489 13017 63160394
Oropharyngeal pain 19.54 9.92 341 315270 94146 63079265
Language disorder 19.51 9.92 37 315574 2123 63171288
Lower limb fracture 19.43 9.92 195 315416 24026 63149385
Leukocytosis 19.42 9.92 65 315546 25870 63147541
Oligohydramnios 19.37 9.92 4 315607 6362 63167049
Eyelid injury 19.32 9.92 6 315605 12 63173399
Aspergillus infection 19.31 9.92 8 315603 8085 63165326
Metastases to liver 19.28 9.92 57 315554 23582 63149829
Cold sweat 19.28 9.92 114 315497 11933 63161478
Orthostatic tremor 19.21 9.92 5 315606 3 63173408
Alanine aminotransferase increased 19.13 9.92 382 315229 103388 63070023
Pituitary tumour benign 19.06 9.92 35 315576 1960 63171451
Herpes zoster 19.05 9.92 541 315070 81921 63091490
Myofascial pain syndrome 18.87 9.92 38 315573 2280 63171131
Nasal congestion 18.85 9.92 222 315389 65438 63107973
Carcinoid tumour pulmonary 18.83 9.92 17 315594 461 63172950
Nail growth abnormal 18.80 9.92 18 315593 527 63172884
Low birth weight baby 18.78 9.92 6 315605 7123 63166288
Sensorimotor disorder 18.59 9.92 17 315594 469 63172942
Epilepsy 18.50 9.92 211 315400 26854 63146557
Granulocytopenia 18.48 9.92 3 315608 5669 63167742
Lung infiltration 18.46 9.92 27 315584 14436 63158975
Creatinine renal clearance decreased 18.41 9.92 33 315578 16275 63157136
Vascular access site infection 18.36 9.92 8 315603 54 63173357
Small intestinal obstruction 18.21 9.92 40 315571 18297 63155114
Product preparation error 18.19 9.92 4 315607 6088 63167323
Snoring 18.18 9.92 54 315557 4148 63169263
Urinary incontinence 18.17 9.92 241 315370 31773 63141638
Reduced facial expression 18.16 9.92 34 315577 1932 63171479
Affect lability 18.15 9.92 106 315505 11045 63162366
Crush syndrome 18.11 9.92 10 315601 119 63173292
Dyslexia 18.04 9.92 14 315597 306 63173105
Abdominal pain 18.03 9.92 1236 314375 292220 62881191
Head injury 18.02 9.92 212 315399 27184 63146227
Neurosis 17.95 9.92 13 315598 255 63173156
Contrast media allergy 17.94 9.92 38 315573 2363 63171048
Distractibility 17.90 9.92 16 315595 428 63172983
Urinary hesitation 17.89 9.92 37 315574 2263 63171148
Respiratory failure 17.87 9.92 378 315233 101480 63071931
Sickle cell anaemia with crisis 17.80 9.92 4 315607 5999 63167412
Breast cancer stage I 17.80 9.92 6 315605 6883 63166528
COVID-19 17.78 9.92 427 315184 112676 63060735
Neck pain 17.78 9.92 461 315150 68857 63104554
Myocardial infarction 17.74 9.92 370 315241 99523 63073888
Device malfunction 17.70 9.92 39 315572 17818 63155593
Rib fracture 17.68 9.92 181 315430 22416 63150995
Vascular access site thrombosis 17.64 9.92 7 315604 36 63173375
Illusion 17.48 9.92 24 315587 1046 63172365
Pneumonia 17.44 9.92 1996 313615 454771 62718640
Pseudomonas infection 17.40 9.92 18 315593 11195 63162216
Complication of device insertion 17.22 9.92 8 315603 7556 63165855
Deep vein thrombosis postoperative 17.18 9.92 106 315505 11263 63162148
Blood bilirubin increased 17.16 9.92 111 315500 37029 63136382
Dysphoria 17.09 9.92 59 315552 4907 63168504
Cytokine release syndrome 17.04 9.92 28 315583 14286 63159125
Carpal tunnel syndrome 16.90 9.92 168 315443 20649 63152762
Abdominal pain lower 16.83 9.92 68 315543 25610 63147801
Candida infection 16.80 9.92 78 315533 28273 63145138
Logorrhoea 16.80 9.92 38 315573 2472 63170939
Device use error 16.77 9.92 4 315607 5757 63167654
Granuloma 16.77 9.92 4 315607 5757 63167654
Breast cancer 16.56 9.92 157 315454 48226 63125185
Anxiety disorder 16.54 9.92 51 315560 3999 63169412
Cytopenia 16.49 9.92 20 315591 11581 63161830
Laryngeal disorder 16.47 9.92 23 315588 1019 63172392
Myocardial ischaemia 16.42 9.92 24 315587 12835 63160576
Pulmonary oedema 16.35 9.92 184 315427 54689 63118722
Social anxiety disorder 16.33 9.92 15 315596 416 63172995
Cardiogenic shock 16.30 9.92 41 315570 17891 63155520
Device breakage 16.30 9.92 20 315591 11522 63161889
Monocyte count abnormal 16.29 9.92 11 315600 192 63173219
Adverse event 16.24 9.92 237 315374 67322 63106089
Orthostatic hypotension 16.24 9.92 109 315502 36051 63137360
Cardiac output decreased 16.18 9.92 22 315589 950 63172461
General physical health deterioration 16.15 9.92 1186 314425 200216 62973195
Complication of device removal 16.14 9.92 3 315608 5139 63168272
Cardiac arrest 16.07 9.92 344 315267 92201 63081210
Sternal fracture 16.07 9.92 35 315576 2219 63171192
Treatment noncompliance 16.02 9.92 114 315497 37211 63136200
Sleep deficit 16.01 9.92 18 315593 638 63172773
Hormone receptor positive HER2 negative breast cancer 16.00 9.92 10 315601 152 63173259
Myoclonic epilepsy 15.96 9.92 25 315586 1229 63172182
Nerve compression 15.86 9.92 88 315523 8999 63164412
Spinal osteoarthritis 15.85 9.92 136 315475 16050 63157361
Hernia 15.83 9.92 112 315499 12462 63160949
Negative symptoms in schizophrenia 15.75 9.92 9 315602 115 63173296
Proteinuria 15.73 9.92 46 315565 19099 63154312
Palmar-plantar erythrodysaesthesia syndrome 15.69 9.92 60 315551 22955 63150456
Fear of injection 15.67 9.92 8 315603 7156 63166255
Heart rate increased 15.59 9.92 353 315258 93885 63079526
Colitis 15.55 9.92 160 315451 48368 63125043
Mental disorder 15.50 9.92 197 315414 25722 63147689
Injection site urticaria 15.42 9.92 29 315582 14044 63159367
Orthostatic intolerance 15.42 9.92 24 315587 1173 63172238
Peroneal nerve palsy 15.40 9.92 56 315555 4779 63168632
Dyspnoea exertional 15.40 9.92 209 315402 60093 63113318
Cerebrospinal fluid retention 15.35 9.92 8 315603 84 63173327
Mydriasis 15.35 9.92 107 315504 11849 63161562
Drug ineffective 15.23 9.92 5593 310018 1039172 62134239
Psychomotor retardation 15.13 9.92 48 315563 3822 63169589
Autoimmune disorder 15.11 9.92 141 315470 17036 63156375
Hippocampal sclerosis 15.11 9.92 8 315603 87 63173324
Peripheral coldness 15.11 9.92 108 315503 12057 63161354
Poor quality product administered 15.05 9.92 42 315569 3114 63170297
Polyneuropathy 15.04 9.92 124 315487 14465 63158946
Upper airway obstruction 15.00 9.92 18 315593 685 63172726
Head titubation 14.99 9.92 20 315591 848 63172563
Eye pain 14.94 9.92 244 315367 33610 63139801
Melaena 14.94 9.92 89 315522 30276 63143135
Arterial occlusive disease 14.93 9.92 64 315547 5894 63167517
Unintended pregnancy 14.92 9.92 6 315605 6173 63167238
Rhinitis allergic 14.86 9.92 22 315589 11705 63161706
Ear infection 14.85 9.92 120 315491 38093 63135318
Vitamin D deficiency 14.82 9.92 119 315492 13773 63159638
Priapism 14.73 9.92 9 315602 131 63173280
Tobacco abuse 14.53 9.92 18 315593 708 63172703
Apparent death 14.48 9.92 24 315587 1238 63172173
Face oedema 14.46 9.92 159 315452 20053 63153358
Cytomegalovirus viraemia 14.45 9.92 5 315606 5644 63167767
Bronchopulmonary aspergillosis 14.40 9.92 13 315598 8622 63164789
Pneumonia viral 14.35 9.92 11 315600 7911 63165500
Hereditary angioedema 14.35 9.92 10 315601 7552 63165859
Rheumatic fever 14.29 9.92 141 315470 42970 63130441
Laboratory test abnormal 14.25 9.92 77 315534 26835 63146576
Mite allergy 14.25 9.92 17 315594 643 63172768
Sinus tachycardia 14.24 9.92 67 315544 24201 63149210
Anal sphincter atony 14.23 9.92 11 315600 239 63173172
Abortion induced 14.20 9.92 18 315593 10224 63163187
Metastases to bone 14.20 9.92 55 315556 20964 63152447
Graft versus host disease 14.14 9.92 8 315603 6755 63166656
Feeling of despair 14.11 9.92 34 315577 2305 63171106
Mental status changes postoperative 14.08 9.92 10 315601 190 63173221
Enuresis 14.04 9.92 36 315575 2537 63170874
Basal ganglion degeneration 13.97 9.92 14 315597 434 63172977
Hot flush 13.94 9.92 343 315268 50816 63122595
Accommodation disorder 13.94 9.92 13 315598 368 63173043
Nephropathy toxic 13.84 9.92 16 315595 9463 63163948
Eye pruritus 13.84 9.92 47 315564 18624 63154787
Clostridium difficile colitis 13.78 9.92 54 315557 20515 63152896
Heparin-induced thrombocytopenia 13.70 9.92 3 315608 4579 63168832
Joint destruction 13.65 9.92 7 315604 6245 63167166
Erythema multiforme 13.64 9.92 92 315519 10077 63163334
White blood cell count abnormal 13.61 9.92 7 315604 6235 63167176
Renal cell carcinoma stage I 13.60 9.92 5 315606 20 63173391
Impaired quality of life 13.60 9.92 116 315495 13667 63159744
Myalgia 13.52 9.92 873 314738 145656 63027755
Haematotoxicity 13.50 9.92 16 315595 9360 63164051
Rhinovirus infection 13.47 9.92 3 315608 4526 63168885
Drug dose titration not performed 13.38 9.92 15 315596 530 63172881
Eosinophil count increased 13.37 9.92 21 315590 10907 63162504
Bacteraemia 13.32 9.92 43 315568 17305 63156106
Sputum discoloured 13.30 9.92 132 315479 16215 63157196
Forceps delivery 13.22 9.92 10 315601 210 63173201
Cardiomyopathy 13.21 9.92 44 315567 17540 63155871
Paraplegia 13.18 9.92 36 315575 2636 63170775
Enthesopathy 13.17 9.92 14 315597 8600 63164811
Total cholesterol/HDL ratio abnormal 13.15 9.92 7 315604 77 63173334
Drug level decreased 13.11 9.92 12 315599 7907 63165504
Lymphadenopathy 13.07 9.92 125 315486 38333 63135078
Peritonitis bacterial 13.05 9.92 4 315607 4875 63168536
Hiatus hernia 13.04 9.92 59 315552 21535 63151876
Hyperglycaemia 13.02 9.92 139 315472 41728 63131683
Transient psychosis 13.02 9.92 6 315605 47 63173364
Haemorrhage 13.01 9.92 219 315392 60803 63112608
Appendicitis 13.01 9.92 13 315598 8216 63165195
Acute hepatic failure 13.00 9.92 47 315564 18280 63155131
Pulmonary haemorrhage 12.97 9.92 10 315601 7171 63166240
Throat irritation 12.95 9.92 122 315489 37525 63135886
Naevus flammeus 12.95 9.92 8 315603 119 63173292
Cholestasis 12.94 9.92 212 315399 29222 63144189
Wrist deformity 12.89 9.92 31 315580 2099 63171312
Anti-actin antibody positive 12.88 9.92 4 315607 8 63173403
Dry eye 12.87 9.92 279 315332 40482 63132929
Diverticulitis 12.85 9.92 130 315481 39427 63133984
Rheumatic disorder 12.84 9.92 39 315572 3033 63170378
Radiculopathy 12.84 9.92 80 315531 8531 63164880
Chronic kidney disease 12.83 9.92 154 315457 45244 63128167
Vaccination site reaction 12.83 9.92 8 315603 121 63173290
Mood swings 12.80 9.92 143 315468 18105 63155306
Wrong patient 12.72 9.92 10 315601 223 63173188
Gastric bypass 12.71 9.92 28 315583 1789 63171622
Atrial flutter 12.71 9.92 18 315593 9754 63163657
Atonic urinary bladder 12.70 9.92 7 315604 83 63173328
Supraventricular tachycardia 12.69 9.92 33 315578 14238 63159173
Facial pain 12.68 9.92 93 315518 10468 63162943
Incontinence 12.60 9.92 100 315511 11532 63161879
Urticaria chronic 12.54 9.92 16 315595 649 63172762
Bursitis 12.50 9.92 256 315355 36785 63136626
Mastocytosis 12.50 9.92 15 315596 571 63172840
Diarrhoea haemorrhagic 12.42 9.92 16 315595 9026 63164385
Epstein-Barr virus infection 12.40 9.92 13 315598 8037 63165374
Vertigo CNS origin 12.40 9.92 5 315606 27 63173384
Glucose tolerance impaired 12.36 9.92 65 315546 6512 63166899
Auditory disorder 12.27 9.92 15 315596 582 63172829
Confusion postoperative 12.24 9.92 10 315601 236 63173175
Injury 12.22 9.92 274 315337 72973 63100438
Accidental overdose 12.22 9.92 173 315438 23136 63150275
Allergy to chemicals 12.14 9.92 38 315573 3004 63170407
Illness anxiety disorder 12.13 9.92 8 315603 134 63173277
Intentional underdose 12.05 9.92 28 315583 1854 63171557
Liver injury 12.00 9.92 220 315391 60300 63113111
Tongue necrosis 12.00 9.92 4 315607 11 63173400
Holmes-Adie pupil 11.97 9.92 5 315606 30 63173381
C-reactive protein 11.90 9.92 52 315559 4830 63168581
Abortion spontaneous 11.90 9.92 164 315447 47031 63126380
Cyclic vomiting syndrome 11.88 9.92 8 315603 139 63173272
Blood lactate dehydrogenase increased 11.77 9.92 67 315544 23049 63150362
Aura 11.77 9.92 20 315591 1053 63172358
Decreased appetite 11.75 9.92 1081 314530 249971 62923440
Breast cancer stage III 11.74 9.92 21 315590 10365 63163046
Bronchopulmonary aspergillosis allergic 11.72 9.92 31 315580 2227 63171184
Hearing disability 11.70 9.92 5 315606 32 63173379
Pleural rub 11.68 9.92 6 315605 61 63173350
Hepatic failure 11.66 9.92 117 315494 35539 63137872
Spinal cord injury 11.64 9.92 18 315593 875 63172536
Lymphocyte count abnormal 11.63 9.92 16 315595 699 63172712
Feeling cold 11.61 9.92 175 315436 23713 63149698
Pleuritic pain 11.60 9.92 74 315537 7955 63165456
Sudden onset of sleep 11.54 9.92 14 315597 539 63172872
Hypoalbuminaemia 11.52 9.92 26 315585 11779 63161632
Numb chin syndrome 11.51 9.92 4 315607 13 63173398
Pathogen resistance 11.44 9.92 9 315602 6389 63167022
Oropharyngeal blistering 11.40 9.92 18 315593 891 63172520
Finger deformity 11.39 9.92 13 315598 7732 63165679
Gestational diabetes 11.39 9.92 15 315596 8381 63165030
Poisoning 11.33 9.92 111 315500 13589 63159822
Post-traumatic neck syndrome 11.30 9.92 29 315582 2045 63171366
Neurogenic bladder 11.28 9.92 39 315572 3246 63170165
Burnout syndrome 11.28 9.92 9 315602 205 63173206
Infection 11.28 9.92 983 314628 228190 62945221
Respiratory distress 11.27 9.92 111 315500 33840 63139571
Cerebral ventricular rupture 11.21 9.92 9 315602 207 63173204
Disturbance in social behaviour 11.18 9.92 3 315608 3990 63169421
Homicidal ideation 11.15 9.92 26 315585 1726 63171685
Post procedural pulmonary embolism 11.11 9.92 10 315601 270 63173141
Ligament pain 11.10 9.92 9 315602 210 63173201
Drug dose omission by device 11.05 9.92 5 315606 4796 63168615
Foot deformity 11.04 9.92 87 315524 27766 63145645
Major depression 11.03 9.92 73 315538 7945 63165466
Second primary malignancy 11.00 9.92 14 315597 7939 63165472
Hyperacusis 10.96 9.92 29 315582 2084 63171327
Onychomycosis 10.94 9.92 14 315597 7918 63165493
Neck injury 10.89 9.92 29 315582 2092 63171319
Myoglobin urine 10.88 9.92 4 315607 16 63173395
Venous valve ruptured 10.86 9.92 3 315608 3 63173408
Self esteem decreased 10.85 9.92 15 315596 658 63172753
Incoherent 10.85 9.92 48 315563 4482 63168929
Hypokalaemia 10.84 9.92 414 315197 103390 63070021
Cholecystitis chronic 10.79 9.92 22 315589 10339 63163072
Renal injury 10.75 9.92 19 315592 9420 63163991
Eyelid skin dryness 10.74 9.92 8 315603 164 63173247
Anaesthesia 10.73 9.92 12 315599 423 63172988
Reflexes abnormal 10.72 9.92 15 315596 666 63172745
Haemophagocytic lymphohistiocytosis 10.70 9.92 23 315588 10604 63162807
Daydreaming 10.69 9.92 11 315600 352 63173059
Serum ferritin increased 10.68 9.92 9 315602 6173 63167238
Failure to thrive 10.67 9.92 12 315599 7186 63166225
Pregnancy with contraceptive device 10.63 9.92 5 315606 4689 63168722
Decreased interest 10.63 9.92 38 315573 3216 63170195
Neoplasm malignant 10.62 9.92 208 315403 29653 63143758
Spinal operation 10.61 9.92 74 315537 8197 63165214
Urine odour abnormal 10.57 9.92 61 315550 6328 63167083
Gingival bleeding 10.52 9.92 30 315581 12557 63160854
Drug specific antibody present 10.51 9.92 4 315607 4255 63169156
Sciatic nerve injury 10.50 9.92 13 315598 511 63172900
Stress 10.50 9.92 421 315190 66746 63106665
Organising pneumonia 10.49 9.92 8 315603 5768 63167643
Depression suicidal 10.47 9.92 26 315585 1797 63171614
Intervertebral disc degeneration 10.46 9.92 122 315489 15610 63157801
Colour blindness acquired 10.41 9.92 6 315605 78 63173333
Abnormal weight gain 10.40 9.92 26 315585 1804 63171607
Basal cell carcinoma 10.38 9.92 89 315522 27902 63145509
Meralgia paraesthetica 10.37 9.92 12 315599 439 63172972
Gastritis 10.37 9.92 127 315484 37176 63136235
Mandibular mass 10.34 9.92 8 315603 174 63173237
Granulocyte count increased 10.34 9.92 17 315594 871 63172540
Ophthalmic herpes zoster 10.29 9.92 28 315583 2045 63171366
Stillbirth 10.29 9.92 11 315600 6739 63166672
Bradykinesia 10.26 9.92 52 315559 5136 63168275
Injection site irritation 10.25 9.92 6 315605 4972 63168439
Cholelithiasis 10.24 9.92 155 315456 43770 63129641
Ligament sprain 10.24 9.92 103 315508 12697 63160714
Aplastic anaemia 10.24 9.92 20 315591 9549 63163862
Post herpetic neuralgia 10.23 9.92 29 315582 2170 63171241
Electrocardiogram ST-T segment abnormal 10.22 9.92 10 315601 301 63173110
Diabetes mellitus 10.21 9.92 356 315255 55454 63117957
Papule 10.19 9.92 8 315603 5683 63167728
Perfume sensitivity 10.18 9.92 16 315595 789 63172622
Urinary tract infection 10.16 9.92 1156 314455 263528 62909883
Calcification metastatic 10.15 9.92 8 315603 179 63173232
Histone antibody positive 10.15 9.92 6 315605 82 63173329
Cardiomegaly 10.12 9.92 49 315562 17565 63155846
Rectal haemorrhage 10.11 9.92 177 315434 48853 63124558
Chronic sinusitis 10.11 9.92 103 315508 12740 63160671
Asthenopia 10.08 9.92 30 315581 2307 63171104
Suspected counterfeit product 10.01 9.92 11 315600 380 63173031
Clumsiness 10.01 9.92 28 315583 2079 63171332
Tunnel vision 9.98 9.92 20 315591 1196 63172215
Sleep attacks 9.96 9.92 6 315605 85 63173326
Soft tissue injury 9.95 9.92 24 315587 1628 63171783
Presbyopia 9.95 9.92 12 315599 459 63172952
Pulmonary tuberculosis 9.95 9.92 5 315606 4512 63168899
Complex regional pain syndrome 9.92 9.92 30 315581 2327 63171084

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 1149.06 10.60 1755 149938 97341 34707897
Somnolence 756.48 10.60 1559 150134 109557 34695681
Drug dependence 694.07 10.60 679 151014 23538 34781700
Withdrawal syndrome 662.63 10.60 498 151195 11957 34793281
Intentional product misuse 422.93 10.60 731 150962 44880 34760358
Miosis 384.44 10.60 324 151369 9211 34796027
Coma 370.93 10.60 691 151002 44987 34760251
Pain 345.48 10.60 1776 149917 202899 34602339
Drug use disorder 314.74 10.60 207 151486 3984 34801254
Overdose 250.18 10.60 916 150777 90143 34715095
Toxicity to various agents 232.48 10.60 1576 150117 198786 34606452
Depressed level of consciousness 217.88 10.60 536 151157 42305 34762933
Altered state of consciousness 210.86 10.60 366 151327 22527 34782711
Drug withdrawal syndrome 201.12 10.60 331 151362 19503 34785735
Prescribed overdose 190.32 10.60 233 151460 10414 34794824
Feeling abnormal 183.69 10.60 648 151045 62587 34742651
Burning sensation 178.51 10.60 301 151392 18093 34787145
Suicidal ideation 175.15 10.60 476 151217 39912 34765326
Drug hypersensitivity 146.78 10.60 715 150978 79814 34725424
Intentional overdose 145.74 10.60 469 151224 43205 34762033
Bradypnoea 141.33 10.60 109 151584 2720 34802518
Prescription drug used without a prescription 139.32 10.60 97 151596 2057 34803181
Confusional state 139.30 10.60 1086 150607 143074 34662164
Gait disturbance 137.71 10.60 731 150962 84409 34720829
Dysarthria 130.40 10.60 389 151304 34393 34770845
Memory impairment 129.28 10.60 448 151245 42870 34762368
Myoclonus 128.57 10.60 230 151463 14495 34790743
Disturbance in attention 122.84 10.60 316 151377 25629 34779609
Insomnia 122.36 10.60 821 150872 103086 34702152
Mydriasis 122.32 10.60 154 151539 7083 34798155
Vision blurred 119.09 10.60 454 151239 45509 34759729
Poisoning 118.53 10.60 200 151493 12026 34793212
Diarrhoea 116.91 10.60 1106 150587 388806 34416432
Therapeutic product effect incomplete 110.06 10.60 473 151220 50068 34755170
Death 109.37 10.60 1153 150540 396896 34408342
Pain in extremity 105.99 10.60 923 150770 125590 34679648
Substance abuse 102.14 10.60 145 151548 7496 34797742
Pre-existing condition improved 100.21 10.60 86 151607 2506 34802732
Febrile neutropenia 95.58 10.60 291 151402 136558 34668680
Neuralgia 94.29 10.60 205 151488 14908 34790330
Pyrexia 92.83 10.60 961 150732 332052 34473186
Dizziness 91.26 10.60 1392 150301 217129 34588109
Fall 88.04 10.60 1301 150392 201584 34603654
Respiratory depression 85.46 10.60 206 151487 16039 34789199
Euphoric mood 84.35 10.60 113 151580 5528 34799710
Agitation 82.83 10.60 478 151215 56921 34748317
Balance disorder 81.33 10.60 371 151322 40283 34764955
Aggression 81.26 10.60 360 151333 38604 34766634
Hypoaesthesia 79.93 10.60 498 151195 60946 34744292
Weight increased 76.95 10.60 677 151016 92356 34712882
Ascites 76.90 10.60 54 151639 46517 34758721
Multiple organ dysfunction syndrome 74.90 10.60 136 151557 76430 34728808
Hypoacusis 73.52 10.60 195 151498 16106 34789132
Suicide attempt 70.25 10.60 346 151347 38770 34766468
Hyperaesthesia 69.61 10.60 93 151600 4537 34800701
Anaemia 69.20 10.60 663 151030 232672 34572566
Amnesia 68.46 10.60 262 151431 26301 34778937
Impaired driving ability 66.52 10.60 69 151624 2564 34802674
Road traffic accident 66.17 10.60 196 151497 17254 34787984
Neutropenia 66.03 10.60 404 151289 156374 34648864
Dependence 65.65 10.60 48 151645 1102 34804136
Middle insomnia 65.57 10.60 111 151582 6691 34798547
Sedation 65.05 10.60 220 151473 20786 34784452
Cytomegalovirus infection 62.31 10.60 18 151675 26117 34779121
Atrial fibrillation 62.25 10.60 296 151397 122097 34683141
Congenital hiatus hernia 61.70 10.60 41 151652 803 34804435
Thinking abnormal 61.63 10.60 102 151591 6035 34799203
Feeling drunk 60.87 10.60 57 151636 1866 34803372
Tremor 60.70 10.60 586 151107 82001 34723237
Head discomfort 57.83 10.60 80 151613 4036 34801202
Sopor 57.62 10.60 148 151545 11988 34793250
Therapeutic response unexpected 57.08 10.60 129 151564 9628 34795610
C-reactive protein abnormal 56.45 10.60 120 151573 8590 34796648
Disease progression 56.36 10.60 259 151434 107818 34697420
Cardiac failure congestive 54.63 10.60 182 151511 83088 34722150
Inadequate analgesia 54.61 10.60 66 151627 2909 34802329
Visual impairment 54.17 10.60 302 151391 35500 34769738
Impaired work ability 53.90 10.60 103 151590 6827 34798411
Prescription form tampering 52.94 10.60 30 151663 436 34804802
Product prescribing error 52.54 10.60 218 151475 22709 34782529
Cough 51.82 10.60 410 151283 149730 34655508
Hospitalisation 51.35 10.60 106 151587 56796 34748442
Fibromyalgia 50.85 10.60 65 151628 3035 34802203
Herpes zoster 50.61 10.60 288 151405 34111 34771127
Pneumonia 50.19 10.60 1195 150498 361432 34443806
Paraesthesia 49.46 10.60 460 151233 63712 34741526
Cytology abnormal 48.77 10.60 27 151666 374 34804864
Bradyphrenia 48.52 10.60 80 151613 4718 34800520
Therapy non-responder 48.52 10.60 59 151634 39087 34766151
Allodynia 48.16 10.60 35 151658 796 34804442
Systemic infection 47.54 10.60 83 151610 5129 34800109
Sepsis 47.33 10.60 478 151215 166083 34639155
Victim of crime 47.17 10.60 26 151667 357 34804881
Product dose omission issue 47.04 10.60 315 151378 119396 34685842
Restlessness 46.17 10.60 226 151467 25256 34779982
Loss of consciousness 45.62 10.60 554 151139 82113 34723125
Speech disorder 43.15 10.60 223 151470 25463 34779775
Terminal state 43.06 10.60 68 151625 3866 34801372
Hypotension 42.89 10.60 690 151003 220959 34584279
Limb discomfort 42.76 10.60 125 151568 10922 34794316
Trigeminal neuralgia 41.96 10.60 38 151655 1191 34804047
Cardiac arrest 41.91 10.60 245 151448 95914 34709324
Neck pain 41.84 10.60 219 151474 25130 34780108
Nervousness 41.68 10.60 135 151558 12471 34792767
Dyspnoea 41.36 10.60 1283 150410 375499 34429739
Gastrointestinal haemorrhage 40.96 10.60 221 151472 88256 34716982
Rash 40.62 10.60 701 150992 222051 34583187
Anxiety 40.45 10.60 631 151062 98797 34706441
Nerve injury 40.21 10.60 62 151631 3453 34801785
Intentional product use issue 39.86 10.60 416 151277 59400 34745838
Disorientation 39.45 10.60 263 151430 32925 34772313
Ventricular fibrillation 38.70 10.60 26 151667 22928 34782310
Photosensitivity reaction 38.28 10.60 117 151576 10477 34794761
Myelosuppression 37.97 10.60 18 151675 19247 34785991
Delirium 37.83 10.60 323 151370 43668 34761570
Visceral congestion 37.57 10.60 27 151666 603 34804635
Drug tolerance 37.50 10.60 54 151639 2828 34802410
Lymphadenopathy 37.32 10.60 41 151652 28422 34776816
Respiratory failure 37.20 10.60 297 151396 108275 34696963
Interstitial lung disease 37.11 10.60 440 151253 64842 34740396
Infection 36.82 10.60 237 151456 90678 34714560
Injection site pain 36.61 10.60 71 151622 38934 34766304
Aspergillus infection 36.36 10.60 5 151688 12249 34792989
Apparent death 35.83 10.60 60 151633 3584 34801654
Depression 35.33 10.60 605 151088 96493 34708745
Cardiogenic shock 35.28 10.60 38 151655 26580 34778658
Sleep disorder 35.22 10.60 247 151446 31441 34773797
Dyskinesia 35.19 10.60 191 151502 22222 34783016
COVID-19 35.18 10.60 195 151498 77355 34727883
Cognitive disorder 34.48 10.60 228 151465 28465 34776773
Breath sounds abnormal 33.79 10.60 85 151608 6796 34798442
Oedematous pancreatitis 33.60 10.60 23 151670 474 34804764
Ejection fraction decreased 33.24 10.60 21 151672 19133 34786105
Ventricular tachycardia 33.00 10.60 40 151653 26539 34778699
Myelopathy 32.80 10.60 47 151646 2450 34802788
Intervertebral disc protrusion 32.35 10.60 106 151587 9850 34795388
Wrong patient 32.24 10.60 15 151678 140 34805098
Acute myocardial infarction 32.16 10.60 122 151571 53597 34751641
Infusion related reaction 32.08 10.60 120 151573 52937 34752301
Reversible airways obstruction 31.58 10.60 22 151671 467 34804771
Epistaxis 31.30 10.60 138 151555 58113 34747125
Arthropathy 31.24 10.60 212 151481 26695 34778543
Drug resistance 31.16 10.60 40 151653 25887 34779351
Rhinalgia 31.03 10.60 30 151663 1023 34804215
Thrombocytopenia 30.99 10.60 484 151209 155763 34649475
Urinary retention 30.96 10.60 266 151427 36022 34769216
Sleep disorder due to general medical condition, insomnia type 30.60 10.60 33 151660 1283 34803955
Pathogen resistance 30.30 10.60 3 151690 9479 34795759
Colour blindness acquired 30.16 10.60 12 151681 73 34805165
Movement disorder 30.08 10.60 119 151574 12129 34793109
Intentional self-injury 30.04 10.60 129 151564 13642 34791596
Mucosal inflammation 29.97 10.60 78 151615 38544 34766694
Graft versus host disease 29.79 10.60 5 151688 10564 34794674
Hallucination, visual 29.56 10.60 154 151539 17637 34787601
Blood bilirubin increased 29.21 10.60 78 151615 38218 34767020
Pancytopenia 29.14 10.60 268 151425 94889 34710349
Acute kidney injury 29.07 10.60 1057 150636 303931 34501307
Blood creatinine increased 28.87 10.60 268 151425 94708 34710530
Withdrawal arrhythmia 28.52 10.60 10 151683 40 34805198
White blood cell count decreased 28.29 10.60 271 151422 95174 34710064
Suicide threat 28.15 10.60 9 151684 25 34805213
Coronary artery disease 28.08 10.60 111 151582 48194 34757044
Clostridium difficile colitis 27.64 10.60 17 151676 15713 34789525
Pulmonary hypertension 27.59 10.60 30 151663 20894 34784344
Intestinal sepsis 27.45 10.60 23 151670 648 34804590
Foetal exposure during pregnancy 27.28 10.60 80 151613 38021 34767217
Prostate cancer 27.14 10.60 85 151608 39564 34765674
Affective disorder 27.03 10.60 59 151634 4301 34800937
Bronchopulmonary aspergillosis 26.95 10.60 15 151678 14644 34790594
Wrong technique in product usage process 26.92 10.60 74 151619 35912 34769326
Dry mouth 26.73 10.60 223 151470 29942 34775296
Hepatic failure 26.59 10.60 70 151623 34461 34770777
Housebound 26.17 10.60 15 151678 223 34805015
Clostridium difficile infection 26.15 10.60 26 151667 18872 34786366
Pleural effusion 26.14 10.60 227 151466 81319 34723919
Accidental poisoning 26.13 10.60 24 151669 766 34804472
International normalised ratio increased 26.10 10.60 111 151582 47216 34758022
Diplopia 26.08 10.60 143 151550 16700 34788538
General physical health deterioration 26.05 10.60 735 150958 127534 34677704
Mental impairment 25.93 10.60 101 151592 10221 34795017
Drug intolerance 25.73 10.60 382 151311 59188 34746050
Bradykinesia 25.65 10.60 54 151639 3839 34801399
Depersonalisation/derealisation disorder 25.63 10.60 21 151672 573 34804665
Rhabdomyolysis 25.61 10.60 427 151266 67736 34737502
Prerenal failure 25.60 10.60 38 151655 2046 34803192
Haemodialysis 25.55 10.60 7 151686 10519 34794719
Off label use 25.51 10.60 1526 150167 417998 34387240
Sinusitis 25.45 10.60 93 151600 41309 34763929
Nausea 25.41 10.60 1211 150482 338697 34466541
Erectile dysfunction 25.41 10.60 165 151528 20472 34784766
Posterior reversible encephalopathy syndrome 25.36 10.60 6 151687 9948 34795290
Septic shock 25.29 10.60 195 151498 71639 34733599
Haematotoxicity 25.14 10.60 3 151690 8191 34797047
Pulmonary thrombosis 25.10 10.60 80 151613 7327 34797911
Flushing 24.75 10.60 66 151627 32354 34772884
Upper respiratory tract infection 24.71 10.60 68 151625 32991 34772247
Appendicitis 24.66 10.60 17 151676 14790 34790448
Multiple sclerosis 24.58 10.60 74 151619 6571 34798667
Nephropathy toxic 24.44 10.60 12 151681 12576 34792662
Phantom limb syndrome 24.32 10.60 15 151678 257 34804981
Haematuria 24.31 10.60 123 151570 49943 34755295
Petit mal epilepsy 24.25 10.60 46 151647 3032 34802206
Lymphoma 24.17 10.60 12 151681 12495 34792743
Dysphemia 23.92 10.60 32 151661 1563 34803675
Joint arthroplasty 23.69 10.60 24 151669 867 34804371
Mood altered 23.64 10.60 89 151604 8863 34796375
Coordination abnormal 23.61 10.60 80 151613 7564 34797674
Formication 23.53 10.60 33 151660 1686 34803552
Nicotinic acid deficiency 23.43 10.60 11 151682 105 34805133
Dysstasia 23.42 10.60 110 151583 12085 34793153
Haemoglobin decreased 23.30 10.60 376 151317 120396 34684842
Poisoning deliberate 23.27 10.60 81 151612 7763 34797475
Irritability 23.21 10.60 185 151508 24505 34780733
Seizure 23.03 10.60 607 151086 104250 34700988
Myocardial infarction 23.02 10.60 378 151315 120707 34684531
White blood cell count increased 23.01 10.60 96 151597 41055 34764183
Bone marrow failure 22.75 10.60 59 151634 29194 34776044
Dysaesthesia 22.73 10.60 38 151655 2267 34802971
Platelet count decreased 22.67 10.60 374 151319 119343 34685895
Anorgasmia 22.63 10.60 23 151670 834 34804404
Hallucination, auditory 22.53 10.60 107 151586 11810 34793428
Quality of life decreased 22.41 10.60 52 151641 3949 34801289
Ataxia 22.39 10.60 119 151574 13734 34791504
Hepatocellular injury 22.31 10.60 169 151524 22042 34783196
Angioedema 22.29 10.60 85 151608 37289 34767949
Drug interaction 22.28 10.60 1196 150497 224750 34580488
Abdominal discomfort 22.22 10.60 160 151533 59675 34745563
Tuberculosis 22.19 10.60 5 151688 8572 34796666
Blepharospasm 22.13 10.60 26 151667 1112 34804126
Hypervolaemia 22.08 10.60 32 151661 19677 34785561
Head circumference abnormal 22.07 10.60 8 151685 36 34805202
Alanine aminotransferase increased 22.06 10.60 234 151459 80581 34724657
Thermophobia 22.06 10.60 9 151684 59 34805179
Haemodynamic instability 21.90 10.60 7 151686 9516 34795722
Clumsiness 21.88 10.60 32 151661 1700 34803538
Myoclonic epilepsy 21.78 10.60 26 151667 1131 34804107
Chest pain 21.77 10.60 403 151290 126359 34678879
Delusion of grandeur 21.73 10.60 26 151667 1134 34804104
Pneumonia aspiration 21.46 10.60 277 151416 41626 34763612
Muscle twitching 21.34 10.60 95 151598 10203 34795035
Accidental overdose 21.22 10.60 155 151538 19985 34785253
Staphylococcal infection 21.20 10.60 72 151621 32688 34772550
Therapy interrupted 21.16 10.60 17 151676 13680 34791558
Substance use 20.88 10.60 20 151673 674 34804564
Thrombotic microangiopathy 20.84 10.60 10 151683 10620 34794618
Aspartate aminotransferase increased 20.70 10.60 191 151502 67592 34737646
Renal failure 20.61 10.60 421 151272 130136 34675102
Depressed mood 20.55 10.60 149 151544 19168 34786070
Post herpetic neuralgia 20.53 10.60 24 151669 1021 34804217
Daydreaming 20.48 10.60 18 151675 542 34804696
Abdominal pain 20.42 10.60 547 151146 163071 34642167
Hyperpyrexia 19.93 10.60 40 151653 2748 34802490
Venoocclusive liver disease 19.90 10.60 5 151688 7961 34797277
Cytomegalovirus viraemia 19.90 10.60 4 151689 7426 34797812
Anger 19.83 10.60 103 151590 11781 34793457
Haemorrhage 19.74 10.60 136 151557 51234 34754004
Blood homocysteine increased 19.72 10.60 13 151680 251 34804987
Limb injury 19.29 10.60 101 151592 11588 34793650
Drug detoxification 19.24 10.60 13 151680 262 34804976
Gait inability 19.22 10.60 155 151538 20603 34784635
Internal fixation of fracture 19.16 10.60 9 151684 86 34805152
Injection site reaction 19.13 10.60 17 151676 13016 34792222
Electrocardiogram QT prolonged 19.10 10.60 102 151591 40850 34764388
Malignant melanoma in situ 19.10 10.60 30 151663 1698 34803540
Weight decreased 19.09 10.60 601 151092 175700 34629538
Somatic symptom disorder 19.08 10.60 19 151674 672 34804566
Dysgraphia 19.04 10.60 35 151658 2252 34802986
Persistent depressive disorder 18.94 10.60 14 151679 327 34804911
Substance use disorder 18.94 10.60 20 151673 759 34804479
Panic attack 18.79 10.60 86 151607 9346 34795892
Back pain 18.73 10.60 675 151018 121114 34684124
Benzodiazepine drug level decreased 18.72 10.60 7 151686 35 34805203
Psychotic behaviour 18.67 10.60 19 151674 690 34804548
Sensory disturbance 18.51 10.60 64 151629 6113 34799125
Renal injury 18.45 10.60 13 151680 11182 34794056
Pseudomonas infection 18.35 10.60 16 151677 12366 34792872
Red blood cell sedimentation rate abnormal 18.32 10.60 45 151648 3544 34801694
Transplant rejection 18.31 10.60 11 151682 10300 34794938
Electric shock sensation 18.29 10.60 10 151683 135 34805103
Condition aggravated 18.07 10.60 1013 150680 191183 34614055
Bladder dilatation 18.03 10.60 27 151666 1465 34803773
Acute respiratory failure 18.02 10.60 71 151622 30857 34774381
Venous oxygen saturation decreased 17.88 10.60 5 151688 7 34805231
Enterococcal infection 17.88 10.60 9 151684 9297 34795941
Vestibular disorder 17.83 10.60 23 151670 1084 34804154
Accessory spleen 17.79 10.60 10 151683 143 34805095
Candida infection 17.73 10.60 31 151662 17684 34787554
Vertigo 17.67 10.60 179 151514 25357 34779881
Leukocytosis 17.61 10.60 50 151643 24015 34781223
Hiccups 17.57 10.60 11 151682 10071 34795167
Back disorder 17.46 10.60 66 151627 6585 34798653
Jaundice 17.44 10.60 75 151618 31807 34773431
Neuropathy peripheral 17.42 10.60 479 151214 82784 34722454
Nerve degeneration 17.41 10.60 11 151682 197 34805041
Basal cell carcinoma 17.41 10.60 37 151656 19621 34785617
Premature baby 17.34 10.60 37 151656 19596 34785642
Hallucination 17.33 10.60 317 151376 51181 34754057
Gastrointestinal disorder 17.29 10.60 82 151611 33866 34771372
Hypogammaglobulinaemia 17.26 10.60 6 151687 7734 34797504
Mental disorder 17.16 10.60 119 151574 15090 34790148
Nervous system disorder 17.13 10.60 115 151578 14428 34790810
Failure to anastomose 17.07 10.60 11 151682 204 34805034
Gamma-glutamyltransferase increased 17.03 10.60 198 151495 29033 34776205
Quadriparesis 17.01 10.60 27 151666 1542 34803696
Drug diversion 16.95 10.60 20 151673 859 34804379
Neutrophil count decreased 16.93 10.60 141 151552 50963 34754275
Sciatica 16.89 10.60 61 151632 5953 34799285
Pericardial effusion 16.79 10.60 53 151640 24609 34780629
Blood folate decreased 16.78 10.60 17 151676 614 34804624
Hepatic cirrhosis 16.70 10.60 31 151662 17283 34787955
Injection site erythema 16.67 10.60 27 151666 15872 34789366
Aspiration 16.57 10.60 100 151593 12094 34793144
Lung infiltration 16.47 10.60 19 151674 12886 34792352
Red blood cell sedimentation rate increased 16.41 10.60 81 151612 9081 34796157
Kidney transplant rejection 16.39 10.60 6 151687 7491 34797747
Hyperbilirubinaemia 16.38 10.60 30 151663 16813 34788425
Mucormycosis 16.33 10.60 3 151690 5939 34799299
Nystagmus 16.04 10.60 51 151642 4664 34800574
Spinal pain 15.92 10.60 59 151634 5830 34799408
Polyneuropathy 15.90 10.60 115 151578 14781 34790457
Upper gastrointestinal haemorrhage 15.89 10.60 57 151636 25461 34779777
Psychogenic seizure 15.86 10.60 13 151680 355 34804883
Carbon dioxide abnormal 15.78 10.60 10 151683 180 34805058
Undifferentiated connective tissue disease 15.73 10.60 6 151687 32 34805206
Motor dysfunction 15.73 10.60 66 151627 6908 34798330
Derealisation 15.72 10.60 16 151677 581 34804657
BK virus infection 15.55 10.60 3 151690 5735 34799503
Melaena 15.48 10.60 90 151603 35290 34769948
Panic reaction 15.46 10.60 25 151668 1450 34803788
Personality disorder 15.37 10.60 22 151671 1146 34804092
Haemoptysis 15.34 10.60 89 151604 34917 34770321
Anaphylactic reaction 15.32 10.60 80 151613 32221 34773017
Hypokalaemia 15.31 10.60 170 151523 58044 34747194
Epstein-Barr virus infection 15.23 10.60 7 151686 7621 34797617
Leukopenia 15.19 10.60 187 151506 62669 34742569
Suicidal behaviour 15.19 10.60 25 151668 1472 34803766
Coma scale abnormal 15.17 10.60 45 151648 3963 34801275
Hyperarousal 15.15 10.60 6 151687 36 34805202
Pruritus 15.12 10.60 485 151208 141496 34663742
Testicular necrosis 15.02 10.60 4 151689 4 34805234
Haemorrhage intracranial 14.98 10.60 29 151664 15917 34789321
COVID-19 pneumonia 14.97 10.60 32 151661 16935 34788303
Anaemia of malignant disease 14.91 10.60 14 151679 460 34804778
Vertebral foraminal stenosis 14.89 10.60 15 151678 538 34804700
Frustration tolerance decreased 14.83 10.60 34 151659 2562 34802676
Behaviour disorder 14.82 10.60 51 151642 4859 34800379
Disseminated intravascular coagulation 14.77 10.60 47 151646 21769 34783469
Visual acuity reduced 14.63 10.60 120 151573 16029 34789209
Dissociation 14.60 10.60 26 151667 1632 34803606
Feeling of body temperature change 14.57 10.60 24 151669 1414 34803824
Abnormal behaviour 14.49 10.60 169 151524 24800 34780438
Drug-induced liver injury 14.47 10.60 70 151623 28762 34776476
Spinal stenosis 14.43 10.60 53 151640 5216 34800022
Product substitution 14.37 10.60 6 151687 42 34805196
Atelectasis 14.37 10.60 35 151658 17692 34787546
Alcohol interaction 14.32 10.60 36 151657 2877 34802361
Influenza virus test positive 14.25 10.60 8 151685 114 34805124
Metabolic acidosis 14.25 10.60 121 151572 43559 34761679
Failure to thrive 14.16 10.60 10 151683 8591 34796647
Bladder cancer 14.11 10.60 31 151662 16247 34788991
Sexual activity increased 14.07 10.60 5 151688 21 34805217
Wrong drug 13.97 10.60 7 151686 78 34805160
Diabetic neuropathy 13.92 10.60 45 151648 4152 34801086
Visual field defect 13.92 10.60 47 151646 4436 34800802
Immunosuppression 13.86 10.60 5 151688 6299 34798939
Oedema peripheral 13.80 10.60 644 151049 119168 34686070
Shock 13.77 10.60 56 151637 24123 34781115
Dialysis 13.77 10.60 17 151676 11191 34794047
Brain injury 13.75 10.60 58 151635 6084 34799154
Bacteraemia 13.68 10.60 42 151651 19675 34785563
Hypoxia 13.66 10.60 163 151530 54932 34750306
Cytokine release syndrome 13.66 10.60 52 151641 22825 34782413
Injection site swelling 13.63 10.60 18 151675 11509 34793729
Application site hypersensitivity 13.61 10.60 8 151685 125 34805113
Sleep disorder due to a general medical condition 13.59 10.60 3 151690 5218 34800020
Reduced facial expression 13.55 10.60 20 151673 1071 34804167
Joint swelling 13.51 10.60 348 151345 59542 34745696
Polyneuropathy in malignant disease 13.48 10.60 10 151683 235 34805003
Body height decreased 13.47 10.60 42 151651 3801 34801437
Fatigue 13.45 10.60 1406 150287 369247 34435991
Phonophobia 13.42 10.60 9 151684 179 34805059
Pseudoporphyria 13.41 10.60 12 151681 370 34804868
Post laminectomy syndrome 13.38 10.60 9 151684 180 34805058
Asphyxia 13.38 10.60 62 151631 6773 34798465
Mitral valve incompetence 13.34 10.60 28 151665 14915 34790323
Cannabinoid hyperemesis syndrome 13.33 10.60 3 151690 0 34805238
Amputee 13.33 10.60 3 151690 0 34805238
Aplasia pure red cell 13.25 10.60 5 151688 6127 34799111
Reading disorder 13.24 10.60 14 151679 532 34804706
Hyponatraemia 13.23 10.60 266 151427 82425 34722813
Acute pulmonary oedema 13.21 10.60 65 151628 7278 34797960
Device leakage 13.18 10.60 6 151687 6569 34798669
Activated partial thromboplastin time prolonged 13.18 10.60 11 151682 8684 34796554
Dissociative disorder 13.14 10.60 13 151680 456 34804782
Eosinophilic myocarditis 13.11 10.60 14 151679 538 34804700
Incorrect route of product administration 13.09 10.60 28 151665 14817 34790421
Product dispensing error 13.09 10.60 58 151635 6216 34799022
Immunosuppressant drug level increased 12.98 10.60 5 151688 6050 34799188
Dysphoria 12.98 10.60 30 151663 2272 34802966
Full blood count decreased 12.93 10.60 38 151655 18050 34787188
Apathy 12.93 10.60 62 151631 6870 34798368
Sensory loss 12.87 10.60 47 151646 4612 34800626
Bacterial infection 12.82 10.60 35 151658 17028 34788210
Panic disorder 12.80 10.60 21 151672 1233 34804005
Drug abuser 12.76 10.60 42 151651 3912 34801326
Prostatic specific antigen increased 12.69 10.60 28 151665 14652 34790586
Electrocardiogram abnormal 12.67 10.60 76 151617 9171 34796067
Age-related macular degeneration 12.66 10.60 11 151682 326 34804912
Unevaluable event 12.66 10.60 86 151607 32504 34772734
Oesophageal carcinoma 12.64 10.60 13 151680 9291 34795947
Micturition urgency 12.63 10.60 59 151634 6466 34798772
Deafness 12.62 10.60 88 151605 11177 34794061
Preternatural anus 12.58 10.60 7 151686 98 34805140
Pseudolymphoma 12.48 10.60 15 151678 657 34804581
Visceral pain 12.37 10.60 6 151687 62 34805176
Nervous system neoplasm 12.34 10.60 8 151685 150 34805088
Small intestinal obstruction 12.33 10.60 29 151664 14837 34790401
Drug withdrawal maintenance therapy 12.28 10.60 7 151686 103 34805135
Gastric haemorrhage 12.15 10.60 16 151677 10245 34794993
Loss of personal independence in daily activities 12.14 10.60 207 151486 32972 34772266
Tumour lysis syndrome 12.08 10.60 36 151657 17023 34788215
Agitation neonatal 12.07 10.60 19 151674 1077 34804161
Astigmatism 12.06 10.60 19 151674 1078 34804160
Tinnitus 12.04 10.60 137 151556 19981 34785257
Lower respiratory tract infection 12.03 10.60 84 151609 31553 34773685
Nightmare 12.01 10.60 105 151588 14286 34790952
Skin toxicity 11.96 10.60 3 151690 4781 34800457
Acute myeloid leukaemia 11.92 10.60 40 151653 18230 34787008
Lymphopenia 11.91 10.60 34 151659 16301 34788937
Genital swelling 11.89 10.60 8 151685 160 34805078
Therapy cessation 11.89 10.60 36 151657 16937 34788301
Injection site haemorrhage 11.81 10.60 15 151678 9753 34795485
Nephrolithiasis 11.80 10.60 80 151613 30253 34774985
Coagulopathy 11.80 10.60 45 151648 19744 34785494
Rash scarlatiniform 11.76 10.60 7 151686 112 34805126
Generalised anxiety disorder 11.73 10.60 16 151677 796 34804442
Haemorrhage subcutaneous 11.72 10.60 29 151664 2295 34802943
Colitis 11.68 10.60 106 151587 37644 34767594
Muscular weakness 11.68 10.60 406 151287 72491 34732747
Chest injury 11.58 10.60 23 151670 1568 34803670
Haematocrit decreased 11.54 10.60 87 151606 32129 34773109
Stent placement 11.41 10.60 48 151645 5030 34800208
Neurotoxicity 11.37 10.60 40 151653 17970 34787268
Vomiting 11.30 10.60 923 150770 246698 34558540
Stress at work 11.29 10.60 9 151684 236 34805002
Generalised tonic-clonic seizure 11.27 10.60 141 151552 21033 34784205
Viral infection 11.22 10.60 39 151654 17584 34787654
Libido increased 11.15 10.60 16 151677 835 34804403
Ventricular arrhythmia 11.15 10.60 5 151688 5523 34799715
Complex regional pain syndrome 11.10 10.60 13 151680 554 34804684
Ankylosing spondylitis 11.09 10.60 51 151642 5553 34799685
Joint injury 11.08 10.60 73 151620 9100 34796138
Device related infection 11.07 10.60 38 151655 17199 34788039
Homicidal ideation 11.01 10.60 31 151662 2651 34802587
Deep vein thrombosis 11.01 10.60 208 151485 65040 34740198
Pneumothorax 11.01 10.60 44 151649 19048 34786190
Renal neoplasm 10.99 10.60 20 151673 1277 34803961
Neonatal hyponatraemia 10.91 10.60 6 151687 82 34805156
Tracheal pain 10.90 10.60 5 151688 45 34805193
Spinal shock 10.90 10.60 5 151688 45 34805193
Wrong product administered 10.90 10.60 49 151644 5285 34799953
Breakthrough pain 10.88 10.60 13 151680 566 34804672
Hepatotoxicity 10.88 10.60 52 151641 21433 34783805
Intestinal perforation 10.86 10.60 14 151679 9046 34796192
Pancreatitis 10.86 10.60 112 151581 38779 34766459
Paralysis recurrent laryngeal nerve 10.81 10.60 5 151688 46 34805192
Reactive psychosis 10.81 10.60 3 151690 4 34805234
Interchange of vaccine products 10.81 10.60 3 151690 4 34805234
Dysmetropsia 10.81 10.60 3 151690 4 34805234
Labelled drug-drug interaction issue 10.79 10.60 10 151683 323 34804915
Peripheral nerve lesion 10.76 10.60 7 151686 132 34805106
Dysgeusia 10.75 10.60 69 151624 26428 34778810
Paresis 10.73 10.60 27 151666 2159 34803079
Accidental death 10.69 10.60 29 151664 2427 34802811
Toxic epidermal necrolysis 10.61 10.60 53 151640 21593 34783645

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Withdrawal syndrome 2075.96 9.83 1413 389010 25441 79328524
Somnolence 1568.64 9.83 3551 386872 235430 79118535
Drug abuse 986.70 9.83 2345 388078 160346 79193619
Intentional product misuse 946.33 9.83 1683 388740 93482 79260483
Drug dependence 922.16 9.83 1067 389356 39702 79314263
Pain 752.94 9.83 5948 384475 697854 78656111
Feeling abnormal 622.15 9.83 1953 388470 157246 79196719
Gait disturbance 436.50 9.83 2092 388331 205414 79148551
Drug withdrawal syndrome 434.47 9.83 681 389742 34037 79319928
Coma 433.51 9.83 1278 389145 99371 79254594
Memory impairment 432.87 9.83 1367 389056 110367 79243598
Therapeutic product effect incomplete 422.17 9.83 1588 388835 140057 79213908
Drug hypersensitivity 396.51 9.83 2663 387760 296253 79057712
Prescribed overdose 386.63 9.83 678 389745 37205 79316760
Miosis 378.52 9.83 426 389997 15363 79338602
Insomnia 373.73 9.83 2263 388160 242907 79111058
Hypoacusis 317.31 9.83 547 389876 29603 79324362
Fall 310.26 9.83 3699 386724 483930 78870035
Burning sensation 292.09 9.83 785 389638 57847 79296118
Suicidal ideation 276.56 9.83 913 389510 75427 79278538
Depressed level of consciousness 274.22 9.83 1067 389356 95585 79258380
Confusional state 270.82 9.83 2559 387864 315438 79038527
Pain in extremity 268.25 9.83 2846 387577 361692 78992273
Pre-existing condition improved 260.63 9.83 217 390206 5346 79348619
Drug use disorder 257.85 9.83 262 390161 8389 79345576
Dizziness 254.17 9.83 3799 386624 522642 78831323
Disturbance in attention 253.89 9.83 681 389742 50120 79303845
Overdose 245.67 9.83 1644 388779 182562 79171403
Altered state of consciousness 245.30 9.83 613 389810 43209 79310756
Tremor 235.92 9.83 1533 388890 168550 79185415
Sciatica 234.49 9.83 509 389914 32713 79321252
Neuralgia 224.90 9.83 502 389921 32882 79321083
Myoclonus 218.76 9.83 444 389979 27216 79326749
Sopor 214.15 9.83 489 389934 32521 79321444
Death 211.24 9.83 1767 388656 564747 78789218
Febrile neutropenia 204.30 9.83 524 389899 230475 79123490
Weight increased 202.64 9.83 2163 388260 275223 79078742
Thinking abnormal 197.32 9.83 281 390142 12880 79341085
Intentional product use issue 194.67 9.83 1344 389079 150768 79203197
Body height decreased 192.98 9.83 224 390199 8356 79345609
Impaired driving ability 191.31 9.83 180 390243 5235 79348730
Maternal exposure during pregnancy 190.15 9.83 233 390190 136305 79217660
Therapeutic response unexpected 186.90 9.83 344 390079 19602 79334363
Speech disorder 182.06 9.83 634 389789 53811 79300154
Euphoric mood 177.63 9.83 204 390219 7522 79346443
Impaired work ability 176.38 9.83 333 390090 19348 79334617
Hypoaesthesia 175.92 9.83 1489 388934 177863 79176102
Pemphigus 174.27 9.83 139 390284 99443 79254522
Anti-cyclic citrullinated peptide antibody positive 169.63 9.83 98 390325 83045 79270920
Feeling drunk 166.98 9.83 157 390266 4562 79349403
Vision blurred 165.88 9.83 985 389438 104913 79249052
Dysarthria 159.89 9.83 706 389717 66916 79287049
Prescription drug used without a prescription 158.32 9.83 143 390280 3942 79350023
Diarrhoea 153.52 9.83 3218 387205 877271 78476694
Exposure during pregnancy 148.96 9.83 165 390258 100967 79252998
Malaise 147.77 9.83 3285 387138 486584 78867381
Respiratory depression 145.78 9.83 378 390045 27252 79326713
Balance disorder 141.26 9.83 898 389525 97959 79256006
Movement disorder 137.78 9.83 367 390056 26892 79327073
Amnesia 137.64 9.83 643 389780 62414 79291551
Glossodynia 136.97 9.83 183 390240 103154 79250811
Multiple organ dysfunction syndrome 136.23 9.83 237 390186 120009 79233956
Neutropenia 134.26 9.83 841 389582 286869 79067096
Hand deformity 132.75 9.83 189 390234 103730 79250235
Alopecia 131.10 9.83 634 389789 230721 79123244
Pericarditis 130.77 9.83 192 390231 104044 79249921
Abdominal discomfort 130.26 9.83 708 389715 250019 79103946
Product dispensing error 129.67 9.83 233 390190 13030 79340935
Product prescribing error 125.63 9.83 493 389930 44320 79309645
Bradypnoea 124.55 9.83 151 390272 5901 79348064
Loss of consciousness 124.08 9.83 1313 389110 166630 79187335
Injection site pain 121.41 9.83 286 390137 129552 79224413
Intentional overdose 120.37 9.83 910 389513 105050 79248915
Visual impairment 117.19 9.83 813 389610 91318 79262647
Gastrointestinal haemorrhage 112.25 9.83 360 390063 147359 79206606
Disorientation 111.52 9.83 604 389819 62172 79291793
Pyrexia 110.98 9.83 2505 387918 676204 78677761
Substance abuse 110.77 9.83 191 390232 10335 79343630
Nervousness 110.74 9.83 388 390035 33027 79320938
Anxiety 108.68 9.83 1765 388658 246747 79107218
Ascites 106.17 9.83 128 390295 75434 79278531
Cytomegalovirus infection 102.72 9.83 40 390383 42604 79311361
Agitation 102.58 9.83 837 389586 98878 79255087
Restlessness 102.12 9.83 475 389948 46017 79307948
Mydriasis 102.09 9.83 250 390173 17393 79336572
Irritability 101.40 9.83 435 389988 40709 79313256
Aggression 99.97 9.83 504 389919 50454 79303511
Depression 99.79 9.83 1553 388870 215237 79138728
Hyperaesthesia 98.79 9.83 198 390225 12024 79341941
Cardiac failure congestive 98.73 9.83 361 390062 142041 79211924
Gait inability 96.76 9.83 555 389868 58362 79295603
Rash 96.36 9.83 2128 388295 576230 78777735
Illness 96.20 9.83 467 389956 46044 79307921
Dyskinesia 95.10 9.83 453 389970 44320 79309645
Expired product administered 94.78 9.83 143 390280 6908 79347057
Infusion related reaction 94.43 9.83 699 389724 229538 79124427
Dysstasia 94.40 9.83 325 390098 27421 79326544
Premature delivery 94.24 9.83 5 390418 23462 79330503
Suicide attempt 94.05 9.83 712 389711 82220 79271745
Device expulsion 93.84 9.83 9 390414 25852 79328113
Systemic lupus erythematosus 92.91 9.83 294 390129 120855 79233110
Dependence 92.32 9.83 84 390339 2338 79351627
Road traffic accident 92.18 9.83 441 389982 43223 79310742
Injection site erythema 90.51 9.83 152 390271 78045 79275920
Loss of personal independence in daily activities 90.35 9.83 832 389591 101748 79252217
Synovitis 90.11 9.83 405 390018 150329 79203636
Dysgraphia 88.57 9.83 104 390319 3928 79350037
Disease progression 88.50 9.83 534 389889 183828 79170137
Sepsis 86.84 9.83 871 389552 268557 79085408
Coronary artery disease 85.69 9.83 117 390306 65357 79288608
Allodynia 85.02 9.83 68 390355 1580 79352385
Stomatitis 83.77 9.83 401 390022 146356 79207609
Anaemia 83.65 9.83 1605 388818 443410 78910555
Injection site swelling 83.44 9.83 65 390358 47067 79306898
Hypotension 82.78 9.83 1588 388835 438729 78915236
Haemoglobin decreased 82.42 9.83 693 389730 221426 79132539
Wrong technique in product usage process 82.40 9.83 147 390276 73728 79280237
Vertigo 82.25 9.83 600 389823 68482 79285483
Crying 81.99 9.83 274 390149 22769 79331196
Intervertebral disc protrusion 80.63 9.83 277 390146 23344 79330621
Atrial fibrillation 80.55 9.83 602 389821 197284 79156681
Poisoning 79.93 9.83 289 390134 24983 79328982
Bradyphrenia 79.66 9.83 167 390256 10473 79343492
Mucosal inflammation 79.35 9.83 156 390267 75424 79278541
Nerve injury 79.35 9.83 155 390268 9237 79344728
Dyspnoea 79.07 9.83 3412 387011 853613 78500352
Pancytopenia 78.02 9.83 483 389940 165262 79188703
Back disorder 77.85 9.83 174 390249 11404 79342561
Systemic infection 77.65 9.83 157 390266 9595 79344370
Toxicity to various agents 77.01 9.83 2651 387772 418889 78935076
White blood cell count decreased 75.12 9.83 576 389847 187712 79166253
Acute myocardial infarction 74.99 9.83 166 390257 76870 79277095
International normalised ratio increased 74.96 9.83 192 390231 84529 79269436
Intentional self-injury 74.75 9.83 336 390087 32083 79321882
Pulmonary hypertension 74.65 9.83 75 390348 48005 79305960
Sedation 74.47 9.83 472 389951 51423 79302542
Hospitalisation 74.15 9.83 226 390197 94010 79259955
Ventricular tachycardia 74.02 9.83 58 390365 41877 79312088
Fibromyalgia 73.85 9.83 554 389869 63786 79290179
Hyperhidrosis 73.44 9.83 1095 389328 150397 79203568
Pleural effusion 73.30 9.83 414 390009 144848 79209117
Mental impairment 71.90 9.83 231 390192 18805 79335160
Pneumonia aspiration 70.97 9.83 566 389857 66401 79287564
Limb discomfort 70.95 9.83 334 390089 32516 79321449
Cognitive disorder 70.85 9.83 585 389838 69341 79284624
Cough 70.38 9.83 1318 389105 365471 78988494
Condition aggravated 70.38 9.83 3062 387361 498062 78855903
Platelet count decreased 69.68 9.83 613 389810 194051 79159914
Septic shock 68.08 9.83 339 390084 122462 79231503
Lower respiratory tract infection 67.54 9.83 364 390059 128856 79225109
Hypersensitivity 66.51 9.83 894 389529 261345 79092620
Cardiac arrest 66.07 9.83 532 389891 171564 79182401
International normalised ratio fluctuation 65.96 9.83 83 390340 3371 79350594
Dry mouth 65.83 9.83 690 389733 87329 79266636
Muscle twitching 65.05 9.83 267 390156 24497 79329468
Apparent death 64.77 9.83 75 390348 2790 79351175
Delirium 63.57 9.83 664 389759 83963 79270002
Bloody discharge 63.47 9.83 62 390361 1891 79352074
Blood iron abnormal 63.37 9.83 53 390370 1314 79352651
Sleep disorder 62.84 9.83 669 389754 85008 79268957
Epistaxis 61.72 9.83 308 390115 111207 79242758
Middle insomnia 61.60 9.83 196 390227 15873 79338092
Multiple sclerosis 61.53 9.83 244 390179 22038 79331927
General physical health deterioration 60.99 9.83 1772 388651 273466 79080499
Urinary retention 60.75 9.83 480 389943 56150 79297815
Ventricular fibrillation 59.13 9.83 42 390381 31884 79322081
Coordination abnormal 59.08 9.83 203 390220 17109 79336856
Hepatic enzyme increased 58.94 9.83 590 389833 182020 79171945
Hallucination, visual 58.86 9.83 316 390107 32413 79321552
Paraesthesia 58.64 9.83 1200 389223 175123 79178842
Aspergillus infection 57.14 9.83 12 390411 19149 79334816
Impaired healing 57.00 9.83 228 390195 87427 79266538
Diplopia 56.75 9.83 318 390105 33148 79320817
Poor quality sleep 56.57 9.83 241 390182 22481 79331484
Blood creatinine increased 56.49 9.83 486 389937 154571 79199394
Sensitivity to weather change 56.44 9.83 123 390300 7924 79346041
Thrombocytopenia 56.32 9.83 936 389487 264323 79089642
Transplant rejection 56.29 9.83 13 390410 19424 79334541
Cataract 56.29 9.83 507 389916 61613 79292352
Congenital hiatus hernia 55.80 9.83 40 390383 784 79353181
Cardiogenic shock 55.75 9.83 74 390349 41840 79312125
Hepatotoxicity 55.64 9.83 104 390319 51248 79302717
Lyme disease 55.42 9.83 75 390348 3275 79350690
Respiratory failure 54.92 9.83 593 389830 180318 79173647
Infection 54.62 9.83 843 389580 240869 79113096
Myelosuppression 53.75 9.83 71 390352 40225 79313740
Drug resistance 53.67 9.83 77 390346 42136 79311829
Aspartate aminotransferase increased 53.48 9.83 428 389995 138213 79215752
Drug ineffective for unapproved indication 52.63 9.83 430 389993 50808 79303157
Muscle spasms 52.56 9.83 1172 389251 173558 79180407
Panic attack 51.41 9.83 245 390178 23971 79329994
Alanine aminotransferase increased 51.32 9.83 528 389895 162042 79191923
Haematocrit decreased 51.17 9.83 143 390280 61169 79292796
Neutrophil count decreased 51.15 9.83 261 390162 93698 79260267
Trigeminal neuralgia 51.10 9.83 75 390348 3534 79350431
Chest pain 49.70 9.83 1029 389394 281275 79072690
Herpes zoster 49.54 9.83 684 389739 92399 79261566
Hypervolaemia 48.46 9.83 84 390339 42606 79311359
Hypomagnesaemia 48.23 9.83 98 390325 46813 79307152
Graft versus host disease 47.82 9.83 8 390415 15018 79338947
Affective disorder 47.20 9.83 117 390306 8202 79345763
Ejection fraction decreased 47.07 9.83 60 390363 34517 79319448
Pneumonia 46.86 9.83 2700 387723 657546 78696419
Spinal stenosis 46.11 9.83 176 390247 15615 79338350
Drug effective for unapproved indication 45.87 9.83 95 390328 5906 79348059
Bronchopulmonary aspergillosis 45.86 9.83 26 390397 22268 79331697
Duodenal ulcer perforation 45.77 9.83 168 390255 66043 79287922
Depressed mood 45.63 9.83 399 390024 48081 79305884
Injection site reaction 45.56 9.83 128 390295 54657 79299308
Infective pulmonary exacerbation of cystic fibrosis 45.26 9.83 5 390418 12846 79341119
Frustration tolerance decreased 45.22 9.83 108 390315 7394 79346571
Inadequate analgesia 44.84 9.83 81 390342 4548 79349417
Sensory disturbance 44.81 9.83 169 390254 14908 79339057
Renal failure 44.68 9.83 703 389720 200265 79153700
Nephropathy toxic 44.67 9.83 22 390401 20397 79333568
Blood bilirubin increased 44.52 9.83 170 390253 66062 79287903
Hallucination 44.39 9.83 627 389796 85118 79268847
Myocardial infarction 44.06 9.83 635 389788 183494 79170471
Diabetic neuropathy 43.58 9.83 95 390328 6121 79347844
Torsade de pointes 43.49 9.83 20 390403 19292 79334673
Wound 43.27 9.83 362 390061 115817 79238148
Appendicitis 43.13 9.83 24 390399 20770 79333195
Dysphemia 43.10 9.83 68 390355 3416 79350549
Dysaesthesia 42.87 9.83 91 390332 5757 79348208
Behaviour disorder 42.59 9.83 95 390328 6218 79347747
Multiple sclerosis relapse 42.26 9.83 380 390043 46153 79307812
Panic reaction 41.88 9.83 79 390344 4586 79349379
Therapy non-responder 41.87 9.83 272 390151 92033 79261932
Lymphadenopathy 41.67 9.83 128 390295 53119 79300846
Therapy cessation 41.65 9.83 75 390348 37487 79316478
Formication 41.35 9.83 82 390341 4941 79349024
Folliculitis 41.32 9.83 136 390287 55244 79298721
Injection site pruritus 41.24 9.83 91 390332 42192 79311773
Electrocardiogram QT prolonged 41.17 9.83 266 390157 90120 79263845
Therapy interrupted 41.01 9.83 56 390367 31285 79322680
Drug ineffective 40.46 9.83 5955 384468 1074958 78279007
Injection site haemorrhage 40.44 9.83 46 390377 27824 79326141
Acute kidney injury 40.15 9.83 2106 388317 517298 78836667
Clostridium difficile infection 39.90 9.83 94 390329 42591 79311374
Coagulopathy 39.83 9.83 72 390351 35934 79318031
Body tinea 39.37 9.83 47 390376 1807 79352158
Feeling of body temperature change 39.18 9.83 83 390340 5243 79348722
Anger 38.91 9.83 177 390246 16985 79336980
Neck pain 38.84 9.83 551 389872 74866 79279099
Pericardial effusion 38.47 9.83 108 390315 46129 79307836
Victim of crime 38.46 9.83 26 390397 462 79353503
Breakthrough pain 38.40 9.83 40 390383 1319 79352646
Cytomegalovirus viraemia 38.29 9.83 8 390415 12813 79341152
Prostate cancer 38.18 9.83 65 390358 33203 79320762
Spinal pain 38.12 9.83 163 390260 15229 79338736
Venoocclusive liver disease 38.06 9.83 6 390417 11765 79342200
Muscular weakness 37.85 9.83 1043 389380 159686 79194279
Wrong patient 37.38 9.83 23 390400 345 79353620
Clostridium difficile colitis 37.12 9.83 63 390360 32220 79321745
Pathogen resistance 37.02 9.83 12 390411 14330 79339635
Ill-defined disorder 36.99 9.83 181 390242 65694 79288271
Irritable bowel syndrome 36.72 9.83 168 390255 62073 79291892
Angioedema 36.58 9.83 220 390203 75815 79278150
Personality disorder 36.53 9.83 88 390335 6058 79347907
Cytokine release syndrome 36.33 9.83 76 390347 35922 79318043
Accidental exposure to product 36.13 9.83 61 390362 31261 79322704
Cytology abnormal 36.10 9.83 22 390401 324 79353641
Back pain 36.05 9.83 1828 388595 302352 79051613
Fungal infection 35.86 9.83 96 390327 41652 79312313
Hypersomnia 35.65 9.83 214 390209 22872 79331093
Helicobacter infection 35.50 9.83 198 390225 69506 79284459
Lung infiltration 35.27 9.83 36 390387 22876 79331089
Tenosynovitis stenosans 35.24 9.83 58 390365 3020 79350945
Neoplasm progression 35.16 9.83 132 390291 51550 79302415
Hepatic cirrhosis 34.97 9.83 74 390349 34832 79319133
Dyslexia 34.83 9.83 19 390404 224 79353741
Synovial fluid analysis 34.82 9.83 50 390373 2309 79351656
Ankle fracture 34.81 9.83 170 390253 16799 79337166
Macular degeneration 34.73 9.83 128 390295 11168 79342797
Flushing 34.72 9.83 271 390152 87997 79265968
Nightmare 34.52 9.83 231 390192 25630 79328335
Pseudomonas infection 34.32 9.83 31 390392 20872 79333093
Acute myeloid leukaemia 33.95 9.83 62 390361 30823 79323142
Epstein-Barr virus infection 33.94 9.83 14 390409 14402 79339563
Muscle injury 33.71 9.83 123 390300 48438 79305527
Prescription form tampering 33.58 9.83 22 390401 370 79353595
Haematotoxicity 33.53 9.83 17 390406 15502 79338463
Bradykinesia 33.52 9.83 101 390322 7942 79346023
Abdominal pain 33.49 9.83 1562 388861 388007 78965958
Haemorrhage 33.44 9.83 285 390138 90833 79263132
Motor dysfunction 33.44 9.83 152 390271 14581 79339384
Libido increased 33.41 9.83 45 390378 1956 79352009
Chest discomfort 33.39 9.83 475 389948 137569 79216396
Leukocytosis 32.92 9.83 106 390317 43349 79310616
Interstitial lung disease 32.82 9.83 752 389671 111848 79242117
Hepatic failure 32.77 9.83 171 390252 61041 79292924
Melaena 32.65 9.83 170 390253 60720 79293245
Multiple allergies 32.55 9.83 119 390304 10341 79343624
Ataxia 32.43 9.83 222 390201 24817 79329148
Injection site warmth 32.32 9.83 16 390407 14791 79339174
White blood cell count increased 32.30 9.83 223 390200 74410 79279555
Orthostatic hypotension 32.30 9.83 153 390270 56011 79297954
Gastrointestinal disorder 32.27 9.83 413 390010 121792 79232173
Product dose omission issue 31.92 9.83 945 389478 246592 79107373
Apathy 31.81 9.83 137 390286 12840 79341125
Nervous system disorder 31.81 9.83 233 390190 26623 79327342
Deep vein thrombosis 31.80 9.83 409 390014 120510 79233455
Head discomfort 31.72 9.83 148 390275 14354 79339611
Cytomegalovirus infection reactivation 31.71 9.83 3 390420 8713 79345252
COVID-19 31.62 9.83 562 389861 157112 79196853
Bedridden 31.54 9.83 130 390293 11949 79342016
Device difficult to use 31.51 9.83 13 390410 13372 79340593
Restless legs syndrome 31.51 9.83 187 390236 19905 79334060
Kidney transplant rejection 31.43 9.83 6 390417 10240 79343725
Psoriatic arthropathy 31.12 9.83 546 389877 77453 79276512
Leukopenia 31.05 9.83 393 390030 116120 79237845
Dementia 30.98 9.83 217 390206 24442 79329523
Mood altered 30.53 9.83 170 390253 17677 79336288
Candida infection 30.52 9.83 91 390332 38123 79315842
Colitis 30.29 9.83 222 390201 73085 79280880
Pulmonary arterial hypertension 30.24 9.83 58 390365 28308 79325657
Mental disorder 30.18 9.83 259 390164 31043 79322922
Emotional disorder 30.14 9.83 145 390278 14242 79339723
Musculoskeletal pain 29.96 9.83 684 389739 101670 79252295
Enterococcal infection 29.80 9.83 20 390403 15640 79338325
Injection site bruising 29.70 9.83 102 390321 40900 79313065
Bladder cancer 29.69 9.83 31 390392 19495 79334470
Skull fracture 29.67 9.83 40 390383 1740 79352225
Thrombotic microangiopathy 29.58 9.83 33 390390 20136 79333829
Posterior reversible encephalopathy syndrome 29.57 9.83 52 390371 26229 79327736
Fatigue 29.55 9.83 4046 386377 925681 78428284
Pruritus 29.36 9.83 1606 388817 393042 78960923
Limb injury 29.35 9.83 246 390177 29282 79324683
Product use issue 29.34 9.83 1282 389141 208540 79145425
Acute respiratory failure 29.32 9.83 171 390252 59370 79294595
Daydreaming 29.17 9.83 29 390394 904 79353061
Sleep disorder due to general medical condition, insomnia type 29.14 9.83 112 390311 43444 79310521
Increased appetite 29.02 9.83 126 390297 11852 79342113
Hypokalaemia 29.01 9.83 513 389910 143527 79210438
Mucormycosis 28.11 9.83 4 390419 8465 79345500
Accidental overdose 28.05 9.83 307 390116 39274 79314691
Adenovirus infection 28.01 9.83 4 390419 8443 79345522
Glaucoma 27.89 9.83 179 390244 19582 79334383
Thirst decreased 27.88 9.83 18 390405 295 79353670
Hyperprolactinaemia 27.84 9.83 67 390356 4609 79349356
Haematuria 27.70 9.83 210 390213 68626 79285339
Reduced facial expression 27.57 9.83 49 390374 2716 79351249
Phantom limb syndrome 27.56 9.83 19 390404 349 79353616
Intervertebral disc disorder 27.52 9.83 68 390355 4757 79349208
Blood calcium decreased 27.46 9.83 73 390350 31746 79322219
Reading disorder 27.44 9.83 29 390394 973 79352992
Withdrawal arrhythmia 27.34 9.83 10 390413 40 79353925
Sensory loss 27.26 9.83 131 390292 12860 79341105
Spinal disorder 27.25 9.83 111 390312 10149 79343816
Photophobia 27.18 9.83 183 390240 20345 79333620
Bacteraemia 27.06 9.83 77 390346 32747 79321218
Left ventricular dysfunction 26.98 9.83 33 390390 19328 79334637
Anorgasmia 26.97 9.83 32 390391 1222 79352743
Fracture 26.89 9.83 191 390232 21610 79332355
Treatment noncompliance 26.87 9.83 148 390275 52120 79301845
Visceral congestion 26.77 9.83 28 390395 928 79353037
Full blood count decreased 26.75 9.83 57 390366 26762 79327203
Renal injury 26.74 9.83 26 390397 16901 79337064
Eye disorder 26.53 9.83 201 390222 23211 79330754
Vomiting 26.46 9.83 2855 387568 662973 78690992
Device related infection 26.43 9.83 83 390340 34211 79319754
Bone erosion 26.40 9.83 29 390394 17818 79336147
Immunosuppressant drug level increased 26.22 9.83 6 390417 9021 79344944
Lower limb fracture 26.13 9.83 199 390224 23016 79330949
Atrial flutter 25.98 9.83 41 390382 21584 79332381
Parkinsonism 25.78 9.83 154 390269 16430 79337535
Sickle cell anaemia with crisis 25.70 9.83 4 390419 7918 79346047
Urticaria 25.65 9.83 700 389723 184501 79169464
Pneumocystis jirovecii pneumonia 25.54 9.83 78 390345 32430 79321535
Granulocytopenia 25.49 9.83 12 390411 11419 79342546
Visual acuity reduced 25.42 9.83 238 390185 29231 79324734
Housebound 25.32 9.83 20 390403 456 79353509
Tension 25.05 9.83 62 390361 4342 79349623
Hepatocellular injury 25.02 9.83 349 390074 47244 79306721
Proteinuria 24.82 9.83 79 390344 32423 79321542
Poor quality product administered 24.75 9.83 55 390368 3590 79350375
Abnormal behaviour 24.68 9.83 280 390143 36141 79317824
Therapeutic product effect decreased 24.64 9.83 612 389811 163251 79190714
Injection site rash 24.60 9.83 31 390392 17923 79336042
Carcinoid tumour pulmonary 24.54 9.83 18 390405 366 79353599
Hostility 24.42 9.83 42 390381 2268 79351697
Tuberculosis 24.41 9.83 23 390400 15175 79338790
Dissociation 24.36 9.83 58 390365 3963 79350002
Hypoxia 24.35 9.83 357 390066 102886 79251079
Myelodysplastic syndrome 24.31 9.83 72 390351 30229 79323736
Post herpetic neuralgia 24.30 9.83 45 390378 2576 79351389
Body mass index increased 24.29 9.83 38 390385 1895 79352070
Snoring 24.24 9.83 71 390352 5495 79348470
Discomfort 24.16 9.83 451 389972 125166 79228799
Gastritis 24.07 9.83 137 390286 47856 79306109
Neoplasm malignant 24.07 9.83 250 390173 31560 79322405
Contraindicated product administered 24.06 9.83 587 389836 156951 79197014
Small intestinal obstruction 23.97 9.83 62 390361 27210 79326755
Drug tolerance 23.95 9.83 95 390328 8580 79345385
Terminal state 23.87 9.83 65 390358 4824 79349141
Caesarean section 23.86 9.83 16 390407 12519 79341446
Hiatus hernia 23.71 9.83 49 390374 23263 79330702
Rhinovirus infection 23.68 9.83 5 390418 7948 79346017
Pregnancy 23.63 9.83 61 390362 26790 79327175
Oropharyngeal pain 23.46 9.83 385 390038 108968 79244997
Rheumatoid factor positive 23.40 9.83 184 390239 59655 79294310
Metabolic acidosis 23.26 9.83 275 390148 82254 79271711
Poisoning deliberate 23.25 9.83 165 390258 18663 79335302
Haemodialysis 23.23 9.83 33 390390 18135 79335830
Feeling of despair 23.16 9.83 46 390377 2775 79351190
Bone marrow failure 22.97 9.83 151 390272 50956 79303009
Sensorimotor disorder 22.94 9.83 25 390398 869 79353096
Drug level decreased 22.89 9.83 22 390401 14380 79339585
Paralysis 22.86 9.83 126 390297 13051 79340914
Blood phosphorus increased 22.86 9.83 11 390412 10336 79343629
Hepatic necrosis 22.82 9.83 8 390415 9092 79344873
Central obesity 22.66 9.83 35 390388 1726 79352239
Unintentional medical device removal 22.65 9.83 5 390418 7707 79346258
Neuropathy peripheral 22.64 9.83 876 389547 140429 79213536
Right ventricular failure 22.56 9.83 51 390372 23446 79330519
Scleritis 22.37 9.83 59 390364 4297 79349668
Hypokinesia 22.37 9.83 165 390258 18895 79335070
Blood lactate dehydrogenase increased 22.35 9.83 107 390316 39063 79314902
Activated partial thromboplastin time prolonged 22.31 9.83 22 390401 14206 79339759
Drug diversion 22.24 9.83 29 390394 1221 79352744
Metastases to liver 22.20 9.83 68 390355 28246 79325719
Dialysis 22.19 9.83 35 390388 18427 79335538
Neurotoxicity 22.15 9.83 83 390340 32435 79321530
Device use error 22.12 9.83 4 390419 7097 79346868
Negative symptoms in schizophrenia 22.11 9.83 12 390411 140 79353825
Foaming at mouth 22.06 9.83 36 390387 1861 79352104
Device issue 22.05 9.83 64 390359 27044 79326921
Substance use 22.04 9.83 25 390398 909 79353056
Blister 22.04 9.83 432 389991 119044 79234921
Cervix neoplasm 22.03 9.83 13 390410 180 79353785
Electric shock sensation 22.01 9.83 24 390399 835 79353130
Dyspnoea exertional 21.98 9.83 297 390126 86776 79267189
Substance use disorder 21.96 9.83 25 390398 913 79353052
Heparin-induced thrombocytopenia 21.84 9.83 10 390413 9672 79344293
Drug interaction 21.84 9.83 2337 388086 412846 78941119
Polyneuropathy 21.81 9.83 197 390226 23954 79330011
Visual field defect 21.80 9.83 95 390328 8950 79345015
Aspiration 21.69 9.83 171 390252 19987 79333978
Myocardial ischaemia 21.68 9.83 59 390364 25460 79328505
Device dislocation 21.35 9.83 61 390362 25909 79328056
Hospice care 21.29 9.83 12 390411 10312 79343653
Vascular access site thrombosis 21.13 9.83 8 390415 36 79353929
Nausea 21.13 9.83 4251 386172 952945 78401020
Body temperature increased 21.11 9.83 129 390294 44291 79309674
Psychomotor skills impaired 21.11 9.83 65 390358 5172 79348793
Feeling jittery 21.10 9.83 121 390302 12720 79341245
Nasal polyps 21.02 9.83 5 390418 7322 79346643
Thermophobia 21.01 9.83 9 390414 59 79353906
Suicide threat 20.88 9.83 9 390414 60 79353905
Migraine 20.65 9.83 568 389855 86925 79267040
Lung consolidation 20.56 9.83 9 390414 8938 79345027
Bacterial infection 20.56 9.83 81 390342 31199 79322766
Inhibitory drug interaction 20.55 9.83 58 390365 4395 79349570
Eyelid injury 20.49 9.83 6 390417 9 79353956
Nasal congestion 20.47 9.83 258 390165 76294 79277671
Abnormal dreams 20.39 9.83 110 390313 11302 79342663
Breast cancer stage I 20.39 9.83 4 390419 6696 79347269
Product quality issue 20.38 9.83 91 390332 33849 79320116
Peripheral coldness 20.33 9.83 141 390282 15829 79338136
Ventricular hypokinesia 20.30 9.83 10 390413 9269 79344696
Failure to thrive 20.13 9.83 17 390406 11827 79342138
Urinary hesitation 20.12 9.83 56 390367 4210 79349755
Nerve compression 19.99 9.83 94 390329 9145 79344820
Normal newborn 19.95 9.83 5 390418 7067 79346898
Pre-eclampsia 19.82 9.83 5 390418 7036 79346929
Pulmonary tuberculosis 19.57 9.83 7 390416 7858 79346107
Serum ferritin increased 19.52 9.83 12 390411 9835 79344130
Drug detoxification 19.46 9.83 16 390407 387 79353578
Deep vein thrombosis postoperative 19.46 9.83 104 390319 10648 79343317
Throat irritation 19.42 9.83 119 390304 40827 79313138
Staphylococcal infection 19.36 9.83 187 390236 58108 79295857
Complication associated with device 19.34 9.83 35 390388 17461 79336504
Logorrhoea 19.32 9.83 56 390367 4309 79349656
Gangrene 19.25 9.83 91 390332 8873 79345092
Delusion of grandeur 19.19 9.83 29 390394 1403 79352562
Device leakage 19.18 9.83 15 390408 10841 79343124
Breath sounds abnormal 19.11 9.83 139 390284 15845 79338120
Rectal haemorrhage 18.99 9.83 261 390162 76039 79277926
Cytopenia 18.96 9.83 45 390378 20338 79333627
Tissue infiltration 18.92 9.83 20 390403 671 79353294
Impaired quality of life 18.90 9.83 128 390295 14258 79339707
Atonic urinary bladder 18.88 9.83 9 390414 78 79353887
Epilepsy 18.87 9.83 293 390130 40567 79313398
Defaecation disorder 18.68 9.83 20 390403 681 79353284
Syringe issue 18.67 9.83 4 390419 6294 79347671
Oesophagitis 18.57 9.83 59 390364 24230 79329735
Device breakage 18.54 9.83 15 390408 10660 79343305
Premature labour 18.41 9.83 9 390414 8381 79345584
Exposure to toxic agent 18.38 9.83 11 390412 9147 79344818
Dysphoria 18.38 9.83 58 390365 4676 79349289
Cardio-respiratory arrest 18.34 9.83 398 390025 108112 79245853
Hypoalbuminaemia 18.27 9.83 49 390374 21248 79332717
Jaundice 18.20 9.83 170 390253 53179 79300786
Hepatitis B 18.19 9.83 9 390414 8323 79345642
Haemophagocytic lymphohistiocytosis 18.17 9.83 51 390372 21786 79332179
Nocardiosis 18.13 9.83 3 390420 5676 79348289
Skin toxicity 18.12 9.83 9 390414 8305 79345660
Hypogammaglobulinaemia 18.12 9.83 22 390401 12929 79341036
Heart rate increased 18.11 9.83 451 389972 120273 79233692
Granuloma 18.06 9.83 9 390414 8288 79345677
Pancreatitis 18.01 9.83 232 390191 68343 79285622
Dysuria 18.00 9.83 350 390073 50601 79303364
Retinitis 17.97 9.83 3 390420 5640 79348325
Bladder dilatation 17.94 9.83 35 390388 2084 79351881
Acute hepatic failure 17.93 9.83 81 390342 30032 79323933
Colorectal cancer 17.91 9.83 10 390413 8637 79345328
Aplastic anaemia 17.90 9.83 38 390385 17867 79336098
Benzodiazepine drug level decreased 17.90 9.83 7 390416 35 79353930
Radiculopathy 17.81 9.83 88 390335 8736 79345229
Intestinal sepsis 17.80 9.83 22 390401 877 79353088
Accident 17.78 9.83 88 390335 8743 79345222
Unevaluable event 17.75 9.83 180 390243 55405 79298560
Psychogenic seizure 17.71 9.83 33 390390 1898 79352067
Petit mal epilepsy 17.69 9.83 65 390358 5662 79348303
Intentional underdose 17.68 9.83 37 390386 2317 79351648
Myofascial pain syndrome 17.67 9.83 34 390389 2003 79351962
Coronary artery bypass 17.66 9.83 4 390419 6058 79347907
Cold sweat 17.65 9.83 154 390269 18545 79335420
Creatinine renal clearance decreased 17.63 9.83 42 390381 18960 79335005
Hormone receptor positive HER2 negative breast cancer 17.56 9.83 10 390413 129 79353836
Illusion 17.55 9.83 31 390392 1710 79352255
Oesophageal carcinoma 17.54 9.83 17 390406 11067 79342898
Aphasia 17.53 9.83 324 390099 46408 79307557
Rheumatoid factor negative 17.52 9.83 25 390398 1148 79352817
Mitral valve incompetence 17.51 9.83 76 390347 28489 79325476
Sleep deficit 17.47 9.83 25 390398 1151 79352814
Photosensitivity reaction 17.41 9.83 169 390254 20958 79333007
Mood swings 17.37 9.83 161 390262 19719 79334246
Cerebrospinal fluid retention 17.36 9.83 9 390414 95 79353870
Eosinophil count increased 17.36 9.83 36 390387 17069 79336896
Accidental poisoning 17.35 9.83 30 390393 1627 79352338
Endophthalmitis 17.27 9.83 5 390418 6423 79347542
Myoclonic epilepsy 17.24 9.83 33 390390 1937 79352028
Nerve degeneration 17.17 9.83 13 390410 278 79353687
Gamma-glutamyltransferase increased 17.13 9.83 369 390054 54311 79299654
Dysgeusia 17.10 9.83 188 390235 56989 79296976
Head titubation 17.06 9.83 22 390401 916 79353049
Completed suicide 17.00 9.83 1007 389416 244760 79109205
Acute respiratory distress syndrome 17.00 9.83 136 390287 43931 79310034
Nicotinic acid deficiency 17.00 9.83 11 390412 181 79353784
Somatic symptom disorder 16.91 9.83 38 390385 2499 79351466
End stage renal disease 16.84 9.83 21 390402 12199 79341766
Sexual activity increased 16.81 9.83 6 390417 22 79353943
Uterine perforation 16.76 9.83 5 390418 6298 79347667
Productive cough 16.71 9.83 318 390105 88013 79265952
Lymphoma 16.68 9.83 38 390385 17422 79336543
Systemic candida 16.64 9.83 6 390417 6700 79347265
Sinus tachycardia 16.61 9.83 109 390314 36799 79317166
Orthostatic tremor 16.61 9.83 6 390417 23 79353942
Chronic kidney disease 16.57 9.83 226 390197 65928 79288037
Disseminated intravascular coagulation 16.56 9.83 105 390318 35737 79318228
Drug dose omission by device 16.54 9.83 5 390418 6245 79347720
Product preparation error 16.53 9.83 4 390419 5789 79348176
Haemodynamic instability 16.47 9.83 38 390385 17344 79336621
Hyperammonaemia 16.43 9.83 18 390405 11075 79342890
Fear of injection 16.43 9.83 8 390415 7466 79346499
Hyperbilirubinaemia 16.43 9.83 63 390360 24455 79329510
Eye pruritus 16.41 9.83 49 390374 20521 79333444
Tumour lysis syndrome 16.37 9.83 61 390362 23878 79330087
Neurosis 16.35 9.83 15 390408 422 79353543
Upper gastrointestinal haemorrhage 16.29 9.83 127 390296 41253 79312712
Malnutrition 16.28 9.83 56 390367 22446 79331519
Hyperpyrexia 16.25 9.83 66 390357 6026 79347939
Deafness 16.23 9.83 166 390257 20871 79333094
Crush syndrome 16.20 9.83 11 390412 197 79353768
Paraplegia 16.16 9.83 58 390365 4995 79348970
Neutropenic sepsis 15.99 9.83 73 390350 26991 79326974
Contrast media allergy 15.95 9.83 37 390386 2485 79351480
Cerebral haemorrhage 15.94 9.83 193 390230 57480 79296485
Sternal fracture 15.88 9.83 37 390386 2493 79351472
Post laminectomy syndrome 15.86 9.83 13 390410 313 79353652
Asphyxia 15.83 9.83 105 390318 11615 79342350
Haemorrhoids 15.80 9.83 81 390342 29047 79324918
Pneumothorax 15.79 9.83 78 390345 28245 79325720
Autoimmune disorder 15.77 9.83 137 390286 16475 79337490
Infection susceptibility increased 15.76 9.83 47 390376 3674 79350291
Monoplegia 15.74 9.83 49 390374 3922 79350043
Blood folate decreased 15.73 9.83 25 390398 1264 79352701
Blood culture positive 15.73 9.83 11 390412 8418 79345547
Coronary arterial stent insertion 15.70 9.83 5 390418 6039 79347926
Suicidal behaviour 15.69 9.83 43 390380 3204 79350761
Cardiomyopathy 15.61 9.83 80 390343 28694 79325271
Brain malformation 15.60 9.83 7 390416 52 79353913
Persistent depressive disorder 15.58 9.83 24 390399 1181 79352784
Pseudolymphoma 15.58 9.83 24 390399 1181 79352784
Methaemoglobinaemia 15.54 9.83 4 390419 5553 79348412
Self-injurious ideation 15.46 9.83 46 390377 3592 79350373
Antinuclear antibody positive 15.44 9.83 78 390345 7812 79346153
Diverticulum 15.41 9.83 31 390392 14865 79339100
Therapeutic product effect delayed 15.38 9.83 41 390382 3005 79350960
Hallucination, auditory 15.36 9.83 162 390261 20531 79333434
Ischaemic stroke 15.34 9.83 97 390326 33034 79320931
Hernia 15.33 9.83 139 390284 16920 79337045
Inappropriate schedule of product administration 15.31 9.83 518 389905 133110 79220855
Complications of transplanted kidney 15.28 9.83 6 390417 6360 79347605
Cytomegalovirus chorioretinitis 15.26 9.83 4 390419 5486 79348479
Amnestic disorder 15.23 9.83 17 390406 607 79353358
Tenderness 15.23 9.83 180 390243 23462 79330503
Complication of device insertion 15.22 9.83 6 390417 6344 79347621
Product prescribing issue 15.20 9.83 49 390374 3996 79349969
Shock 15.18 9.83 138 390285 43410 79310555
Prothrombin time prolonged 15.17 9.83 38 390385 16861 79337104
Hydronephrosis 15.09 9.83 40 390383 17414 79336551
Quality of life decreased 15.08 9.83 95 390328 10325 79343640
Tooth extraction 15.05 9.83 19 390404 10976 79342989
Cardiomegaly 15.03 9.83 72 390351 26280 79327685
Carpal tunnel syndrome 15.02 9.83 154 390269 19374 79334591
Venous oxygen saturation decreased 15.02 9.83 5 390418 14 79353951
C-reactive protein 14.95 9.83 56 390367 4923 79349042
Drug specific antibody present 14.81 9.83 7 390416 6645 79347320
Alcohol interaction 14.79 9.83 55 390368 4819 79349146
Blood urea increased 14.76 9.83 160 390263 48630 79305335
Haemorrhage intracranial 14.68 9.83 72 390351 26121 79327844
Somnambulism 14.49 9.83 61 390362 5660 79348305
Rheumatic disorder 14.45 9.83 41 390382 3117 79350848
Wrist deformity 14.44 9.83 32 390391 2085 79351880
Anal fistula 14.42 9.83 8 390415 6936 79347029
Pituitary tumour benign 14.37 9.83 36 390387 2540 79351425
Myopathy 14.32 9.83 52 390371 20511 79333454
Intestinal perforation 14.27 9.83 41 390382 17385 79336580
Hepatitis B reactivation 14.27 9.83 6 390417 6102 79347863
Intestinal ischaemia 14.26 9.83 27 390396 13243 79340722
Cholestasis 14.25 9.83 345 390078 51764 79302201
Spinal osteoarthritis 14.24 9.83 136 390287 16791 79337174
Transient psychosis 14.18 9.83 7 390416 66 79353899
Juvenile idiopathic arthritis 14.17 9.83 3 390420 4760 79349205
Allergy to chemicals 14.14 9.83 36 390387 2566 79351399
N-terminal prohormone brain natriuretic peptide increased 14.13 9.83 3 390420 4752 79349213
Basal cell carcinoma 14.12 9.83 116 390307 37259 79316706
Laboratory test abnormal 14.10 9.83 80 390343 27968 79325997
Cyclic vomiting syndrome 14.06 9.83 8 390415 103 79353862
Auditory disorder 14.03 9.83 15 390408 510 79353455
Language disorder 14 9.83 41 390382 3173 79350792
Head injury 13.99 9.83 259 390164 37110 79316855
Lymphoproliferative disorder 13.97 9.83 5 390418 5610 79348355
Cardiac output decreased 13.94 9.83 29 390394 1809 79352156
Adverse event 13.92 9.83 209 390214 60005 79293960
Radicular pain 13.90 9.83 13 390410 375 79353590
Injection site urticaria 13.87 9.83 26 390397 12800 79341165
Palmar-plantar erythrodysaesthesia syndrome 13.85 9.83 100 390323 33034 79320931
Hypoventilation 13.85 9.83 71 390352 7153 79346812
Graft versus host disease in gastrointestinal tract 13.68 9.83 7 390416 6349 79347616
Hepatic cancer 13.59 9.83 19 390404 10510 79343455
Brain herniation 13.58 9.83 10 390413 7453 79346512
Total lung capacity decreased 13.57 9.83 38 390385 2867 79351098
CADASIL 13.56 9.83 6 390417 43 79353922
Nystagmus 13.54 9.83 89 390334 9815 79344150
Pulmonary alveolar haemorrhage 13.50 9.83 22 390401 11435 79342530
Upper limb fracture 13.50 9.83 141 390282 17826 79336139
Hip arthroplasty 13.49 9.83 111 390312 35645 79318320
Pneumonitis 13.47 9.83 213 390210 60647 79293318
Age-related macular degeneration 13.44 9.83 20 390403 954 79353011
Anal sphincter atony 13.43 9.83 12 390411 326 79353639
Supraventricular tachycardia 13.40 9.83 56 390367 21214 79332751
Blood immunoglobulin E increased 13.39 9.83 6 390417 5876 79348089
Soft tissue injury 13.39 9.83 28 390395 1753 79352212
Seizure 13.38 9.83 1086 389337 187748 79166217
Oedematous pancreatitis 13.36 9.83 22 390401 1146 79352819
Drug level below therapeutic 13.25 9.83 17 390406 9753 79344212
Total cholesterol/HDL ratio abnormal 13.17 9.83 7 390416 78 79353887
Sudden onset of sleep 13.14 9.83 16 390407 628 79353337
Foot fracture 13.14 9.83 165 390258 21816 79332149
Urinary incontinence 13.12 9.83 277 390146 40632 79313333
Homicidal ideation 13.10 9.83 42 390381 3415 79350550
Crepitations 13.08 9.83 89 390334 9928 79344037
Dissociative disorder 13.01 9.83 18 390405 803 79353162
Anhedonia 12.99 9.83 34 390389 14864 79339101
Tricuspid valve incompetence 12.98 9.83 51 390372 19661 79334304
Amputee 12.97 9.83 3 390420 0 79353965
Blood arsenic increased 12.97 9.83 3 390420 0 79353965
Vaccination site reaction 12.94 9.83 8 390415 121 79353844
Libido decreased 12.91 9.83 56 390367 5265 79348700
Complex regional pain syndrome 12.91 9.83 30 390393 2018 79351947
Oliguria 12.90 9.83 39 390384 16270 79337695
Arthralgia 12.90 9.83 2536 387887 569267 78784698
Coronary artery stenosis 12.90 9.83 26 390397 12458 79341507
Needle issue 12.84 9.83 28 390395 13040 79340925
Vascular access site infection 12.83 9.83 8 390415 123 79353842
Distractibility 12.81 9.83 17 390406 728 79353237
Vascular device infection 12.81 9.83 19 390404 10257 79343708
Injection site mass 12.80 9.83 53 390370 20131 79333834
Clumsiness 12.78 9.83 39 390384 3088 79350877
Abnormal weight gain 12.76 9.83 35 390388 2609 79351356
Failure to anastomose 12.74 9.83 10 390413 226 79353739
Cholecystitis chronic 12.66 9.83 18 390405 9888 79344077
Neuropathic arthropathy 12.64 9.83 12 390411 353 79353612
Holmes-Adie pupil 12.63 9.83 5 390418 26 79353939
Blood homocysteine increased 12.62 9.83 13 390410 423 79353542
Squamous cell carcinoma 12.62 9.83 37 390386 15585 79338380
Pulseless electrical activity 12.59 9.83 32 390391 14128 79339837
Device malfunction 12.58 9.83 58 390365 21390 79332575
COVID-19 pneumonia 12.58 9.83 86 390337 28763 79325202
Mental status changes postoperative 12.57 9.83 9 390414 176 79353789
Glucose tolerance impaired 12.52 9.83 75 390348 8009 79345956
Peritonitis 12.51 9.83 83 390340 27953 79326012
Product substitution 12.45 9.83 7 390416 88 79353877
Lipoma 12.36 9.83 38 390385 3021 79350944
Streptococcal infection 12.35 9.83 15 390408 8815 79345150
Respiratory rate increased 12.33 9.83 59 390364 21541 79332424
Incoherent 12.32 9.83 72 390351 7620 79346345
Prerenal failure 12.30 9.83 43 390380 3655 79350310
Calcification metastatic 12.29 9.83 8 390415 133 79353832
Meralgia paraesthetica 12.28 9.83 14 390409 512 79353453
Cardiotoxicity 12.21 9.83 26 390397 12213 79341752
Hearing disability 12.21 9.83 6 390417 56 79353909
Prostatic specific antigen increased 12.19 9.83 20 390403 10366 79343599
Rash erythematous 12.19 9.83 204 390219 57565 79296400
Arterial occlusive disease 12.18 9.83 77 390346 8379 79345586
Sinusitis 12.14 9.83 809 389614 194692 79159273
Perfume sensitivity 12.06 9.83 18 390405 861 79353104
Angina unstable 12.04 9.83 41 390382 16486 79337479
Hyperarousal 12.04 9.83 5 390418 30 79353935
Sedation complication 12.02 9.83 38 390385 15631 79338334
Brain contusion 12.02 9.83 23 390400 1350 79352615
Respiratory distress 11.99 9.83 207 390216 58132 79295833
Visceral pain 11.98 9.83 7 390416 95 79353870
Haemorrhage subcutaneous 11.97 9.83 51 390372 4758 79349207
Liver function test abnormal 11.93 9.83 233 390190 64242 79289723
Pulmonary thrombosis 11.88 9.83 101 390322 12070 79341895
Pneumonia fungal 11.88 9.83 23 390400 11187 79342778
Skin cancer 11.88 9.83 36 390387 15004 79338961
Illness anxiety disorder 11.85 9.83 10 390413 251 79353714
Coronary artery occlusion 11.85 9.83 37 390386 15278 79338687
Oedema 11.84 9.83 707 389716 118873 79235092
Affect lability 11.83 9.83 95 390328 11164 79342801
Preternatural anus 11.79 9.83 7 390416 98 79353867
Surgery 11.79 9.83 103 390320 32663 79321302
Pulmonary haemorrhage 11.78 9.83 35 390388 14682 79339283
Congestive cardiomyopathy 11.78 9.83 25 390398 11755 79342210
Feeling cold 11.78 9.83 202 390221 28527 79325438
Ventricular hypertrophy 11.74 9.83 10 390413 6928 79347037
Cerebral disorder 11.73 9.83 56 390367 5482 79348483
Disseminated tuberculosis 11.72 9.83 3 390420 4180 79349785
Hepatomegaly 11.70 9.83 50 390373 18824 79335141
Thrombosis in device 11.70 9.83 6 390417 5436 79348529
Diarrhoea haemorrhagic 11.69 9.83 30 390393 13204 79340761
Hypercalcaemia 11.63 9.83 126 390297 38304 79315661
Peritonitis bacterial 11.63 9.83 18 390405 9549 79344416
Lumbar spinal stenosis 11.62 9.83 54 390369 5228 79348737
Blood pressure inadequately controlled 11.60 9.83 8 390415 6169 79347796
Deafness neurosensory 11.60 9.83 10 390413 6888 79347077
Neuroleptic malignant syndrome 11.60 9.83 83 390340 27476 79326489
Second primary malignancy 11.58 9.83 34 390389 14316 79339649
Pleural rub 11.52 9.83 6 390417 64 79353901
Vertigo CNS origin 11.52 9.83 5 390418 34 79353931
Enuresis 11.51 9.83 38 390385 3138 79350827
Venoocclusive disease 11.50 9.83 4 390419 4569 79349396
Oxygen consumption increased 11.46 9.83 5 390418 4974 79348991
Dyslipidaemia 11.37 9.83 25 390398 11608 79342357
Renal cancer 11.36 9.83 27 390396 12199 79341766
Fractured coccyx 11.36 9.83 19 390404 1003 79352962
Social anxiety disorder 11.35 9.83 14 390409 557 79353408
Anaphylactic shock 11.31 9.83 117 390306 35879 79318086
Hereditary angioedema 11.30 9.83 6 390417 5329 79348636
Facial pain 11.29 9.83 101 390322 12249 79341716
Food craving 11.25 9.83 25 390398 1632 79352333
Aplasia 11.25 9.83 13 390410 7807 79346158
Gastric haemorrhage 11.20 9.83 37 390386 15013 79338952
Subileus 11.14 9.83 56 390367 5598 79348367
Respiratory syncytial virus infection 11.13 9.83 18 390405 9384 79344581
Hypotonia 11.13 9.83 104 390319 12766 79341199
Confusion postoperative 11.11 9.83 9 390414 213 79353752
Reflexes abnormal 11.11 9.83 18 390405 925 79353040
Overweight 11.10 9.83 45 390378 4105 79349860
Large intestine polyp 11.08 9.83 29 390394 12679 79341286
Nail growth abnormal 11.07 9.83 13 390410 491 79353474
Ventricular dysfunction 11.05 9.83 8 390415 6015 79347950
Accessory spleen 11.04 9.83 9 390414 215 79353750
Electrocardiogram abnormal 11.03 9.83 128 390295 16609 79337356
Purpura 11.00 9.83 145 390278 19382 79334583
Urinary tract infection 11.00 9.83 1176 389247 273336 79080629
Polyneuropathy in malignant disease 11 9.83 10 390413 278 79353687
Anal abscess 10.99 9.83 18 390405 9337 79344628
Intervertebral disc degeneration 10.99 9.83 122 390301 15663 79338302
Arteriospasm coronary 10.98 9.83 10 390413 6706 79347259
Decreased appetite 10.94 9.83 1489 388934 340929 79013036
Diabetes insipidus 10.93 9.83 6 390417 5231 79348734
Urine odour abnormal 10.89 9.83 60 390363 6213 79347752
Pulmonary oedema 10.85 9.83 339 390084 87915 79266050
Accommodation disorder 10.84 9.83 14 390409 584 79353381
Abdominal distension 10.81 9.83 477 389946 119173 79234792
Subdural haematoma 10.79 9.83 100 390323 31334 79322631
Subdural haemorrhage 10.79 9.83 8 390415 5940 79348025
Ear infection 10.79 9.83 112 390311 34320 79319645
Cerebral infarction 10.75 9.83 158 390265 45518 79308447
Renal tubular necrosis 10.74 9.83 75 390348 24964 79329001
Blindness 10.72 9.83 197 390226 28186 79325779
Toxic encephalopathy 10.68 9.83 94 390329 11346 79342619
Unintended pregnancy 10.68 9.83 3 390420 3930 79350035
Near death experience 10.64 9.83 13 390410 512 79353453
Peroneal nerve palsy 10.63 9.83 58 390365 5984 79347981
Subarachnoid haemorrhage 10.63 9.83 73 390350 24392 79329573
Bone density decreased 10.63 9.83 106 390317 13241 79340724
Haemolysis 10.60 9.83 30 390393 12782 79341183
Migraine without aura 10.59 9.83 10 390413 292 79353673
Narcolepsy 10.59 9.83 21 390402 1265 79352700
Basal ganglion degeneration 10.59 9.83 12 390411 436 79353529
Lymphocyte count abnormal 10.57 9.83 23 390400 1480 79352485
Device related sepsis 10.55 9.83 9 390414 6231 79347734
Pulmonary embolism 10.54 9.83 711 389712 170943 79183022
Internal fixation of fracture 10.53 9.83 11 390412 364 79353601
Troponin I increased 10.52 9.83 5 390418 4733 79349232
Thought blocking 10.50 9.83 9 390414 231 79353734
Pyometra 10.49 9.83 6 390417 78 79353887
Blood sodium decreased 10.49 9.83 108 390315 33147 79320818
Herpes simplex 10.48 9.83 28 390395 12159 79341806
Cystic fibrosis 10.46 9.83 3 390420 3877 79350088
Periarthritis 10.44 9.83 35 390388 2913 79351052
Hypernatraemia 10.43 9.83 36 390387 14415 79339550
Blood lactic acid increased 10.43 9.83 30 390393 12714 79341251
Malignant melanoma in situ 10.41 9.83 31 390392 2421 79351544
Laryngeal disorder 10.39 9.83 19 390404 1077 79352888
Depersonalisation/derealisation disorder 10.37 9.83 26 390397 1836 79352129
Gastrointestinal inflammation 10.36 9.83 13 390410 7531 79346434
Tracheal pain 10.33 9.83 5 390418 45 79353920
Renal cell carcinoma stage I 10.33 9.83 5 390418 45 79353920
Mastocytosis 10.31 9.83 13 390410 529 79353436
Self esteem decreased 10.31 9.83 18 390405 984 79352981
Hiccups 10.27 9.83 21 390402 10010 79343955
Diabetic foot 10.21 9.83 40 390383 3592 79350373
Hyponatraemia 10.21 9.83 741 389682 177107 79176858
Quadriparesis 10.20 9.83 39 390384 3462 79350503
Dry skin 10.20 9.83 254 390169 67741 79286224
Tic 10.18 9.83 35 390388 2951 79351014
Platelet count increased 10.17 9.83 66 390357 22340 79331625
Klebsiella infection 10.15 9.83 41 390382 15679 79338286
Laryngeal pain 10.12 9.83 9 390414 6105 79347860
Anxiety disorder 10.11 9.83 44 390379 4143 79349822
Paralysis recurrent laryngeal nerve 10.09 9.83 7 390416 130 79353835
Wrong dosage formulation 10.06 9.83 3 390420 5 79353960
Arthritis 10.05 9.83 672 389751 114208 79239757
Sputum culture positive 10.05 9.83 3 390420 3778 79350187
Abortion induced 10.03 9.83 12 390411 7097 79346868
Human herpesvirus 6 infection 10.03 9.83 7 390416 5363 79348602
Electrocardiogram ST segment elevation 10.01 9.83 16 390407 8381 79345584
Occipital neuralgia 10.00 9.83 12 390411 464 79353501
Clostridial infection 9.96 9.83 8 390415 5706 79348259
Intestinal stenosis 9.94 9.83 3 390420 3751 79350214
Ligament pain 9.94 9.83 9 390414 249 79353716
Papule 9.93 9.83 13 390410 7394 79346571
Heart rate decreased 9.93 9.83 265 390158 70051 79283914
Throat tightness 9.92 9.83 88 390335 27819 79326146
Pleural fibrosis 9.88 9.83 4 390419 4163 79349802
Injection related reaction 9.87 9.83 18 390405 1018 79352947
Blood glucose increased 9.85 9.83 461 389962 114514 79239451
Parainfluenzae virus infection 9.85 9.83 8 390415 5674 79348291
Rash pruritic 9.84 9.83 271 390152 71358 79282607
Tongue paralysis 9.84 9.83 12 390411 472 79353493

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Telangiectasia congenital 34.38 28.19 9 239 18 89526

Pharmacologic Action:

SourceCodeDescription
ATC N02BF02 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Gabapentinoids
MeSH PA D000700 Analgesics
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D000927 Anticonvulsants
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018689 Sensory System Agents
MeSH PA D014149 Tranquilizing Agents
CHEBI has role CHEBI:35623 anticonvulsants
CHEBI has role CHEBI:38215 calcium channel blockers

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Postherpetic neuralgia indication 2177002
Generalized anxiety disorder indication 21897009 DOID:14320
Partial seizure indication 29753000
Fibromyalgia indication 203082005 DOID:631
Peripheral neuropathic pain indication 279981003
Diabetic peripheral neuropathy indication 424736006
Central neuropathic pain indication 1259040000
Partial Epilepsy Treatment Adjunct indication
Suicidal thoughts contraindication 6471006
Weight gain finding contraindication 8943002
Reduced visual acuity contraindication 13164000
Depressive disorder contraindication 35489007
Angioedema contraindication 41291007 DOID:1558
Chronic heart failure contraindication 48447003
Disorder of muscle contraindication 129565002 DOID:423
Decompensated cardiac failure contraindication 195111005
Impaired renal function disorder contraindication 197663003
Atrioventricular block contraindication 233917008 DOID:0050820
Rhabdomyolysis contraindication 240131006
Drowsy contraindication 271782001
Peripheral edema contraindication 271809000
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Dizziness contraindication 404640003




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.97 acidic
pKa2 10.4 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
165MG LYRICA CR UPJOHN N209501 Oct. 11, 2017 RX TABLET, EXTENDED RELEASE ORAL 10022447 Nov. 2, 2026 TREATMENT OF NEUROPATHIC PAIN ASSOCIATED WITH DIABETIC PERIPHERAL NEUROPATHY
165MG LYRICA CR UPJOHN N209501 Oct. 11, 2017 RX TABLET, EXTENDED RELEASE ORAL 10022447 Nov. 2, 2026 TREATMENT OF POSTHERPETIC NEURALGIA
165MG LYRICA CR UPJOHN N209501 Oct. 11, 2017 RX TABLET, EXTENDED RELEASE ORAL 8945620 Nov. 2, 2026 TREATMENT OF NEUROPATHIC PAIN ASSOCIATED WITH DIABETIC PERIPHERAL NEUROPATHY
165MG LYRICA CR UPJOHN N209501 Oct. 11, 2017 RX TABLET, EXTENDED RELEASE ORAL 8945620 Nov. 2, 2026 TREATMENT OF POSTHERPETIC NEURALGIA
330MG LYRICA CR UPJOHN N209501 Oct. 11, 2017 RX TABLET, EXTENDED RELEASE ORAL 10022447 Nov. 2, 2026 TREATMENT OF NEUROPATHIC PAIN ASSOCIATED WITH DIABETIC PERIPHERAL NEUROPATHY
330MG LYRICA CR UPJOHN N209501 Oct. 11, 2017 RX TABLET, EXTENDED RELEASE ORAL 10022447 Nov. 2, 2026 TREATMENT OF POSTHERPETIC NEURALGIA
330MG LYRICA CR UPJOHN N209501 Oct. 11, 2017 RX TABLET, EXTENDED RELEASE ORAL 8945620 Nov. 2, 2026 TREATMENT OF NEUROPATHIC PAIN ASSOCIATED WITH DIABETIC PERIPHERAL NEUROPATHY
330MG LYRICA CR UPJOHN N209501 Oct. 11, 2017 RX TABLET, EXTENDED RELEASE ORAL 8945620 Nov. 2, 2026 TREATMENT OF POSTHERPETIC NEURALGIA
82.5MG LYRICA CR UPJOHN N209501 Oct. 11, 2017 RX TABLET, EXTENDED RELEASE ORAL 10022447 Nov. 2, 2026 TREATMENT OF NEUROPATHIC PAIN ASSOCIATED WITH DIABETIC PERIPHERAL NEUROPATHY
82.5MG LYRICA CR UPJOHN N209501 Oct. 11, 2017 RX TABLET, EXTENDED RELEASE ORAL 10022447 Nov. 2, 2026 TREATMENT OF POSTHERPETIC NEURALGIA
82.5MG LYRICA CR UPJOHN N209501 Oct. 11, 2017 RX TABLET, EXTENDED RELEASE ORAL 8945620 Nov. 2, 2026 TREATMENT OF NEUROPATHIC PAIN ASSOCIATED WITH DIABETIC PERIPHERAL NEUROPATHY
82.5MG LYRICA CR UPJOHN N209501 Oct. 11, 2017 RX TABLET, EXTENDED RELEASE ORAL 8945620 Nov. 2, 2026 TREATMENT OF POSTHERPETIC NEURALGIA

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Voltage-dependent calcium channel subunit alpha-2/delta-1 Ion channel MODULATOR IC50 7.10 WOMBAT-PK CHEMBL
Voltage-dependent calcium channel subunit alpha-2/delta-2 Ion channel MODULATOR IC50 7.26 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Large neutral amino acids transporter small subunit 1 Transporter IC50 3.80 WOMBAT-PK
Uncharacterized protein; Voltage-dependent calcium channel alpha-2 delta subunit Ion channel IC50 7.14 CHEMBL

External reference:

IDSource
4024924 VUID
N0000171595 NUI
D02716 KEGG_DRUG
4024924 VANDF
C0657912 UMLSCUI
CHEBI:64356 CHEBI
CHEMBL1059 ChEMBL_ID
DB00230 DRUGBANK_ID
D000069583 MESH_DESCRIPTOR_UI
5486971 PUBCHEM_CID
7643 INN_ID
5484 IUPHAR_LIGAND_ID
530085-00-8 SECONDARY_CAS_RN
55JG375S6M UNII
187832 RXNORM
19649 MMSL
67412 MMSL
79550 MMSL
d05508 MMSL
010083 NDDF
415159003 SNOMEDCT_US
415160008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lyrica HUMAN PRESCRIPTION DRUG LABEL 1 0071-1012 CAPSULE 25 mg ORAL NDA 33 sections
Lyrica HUMAN PRESCRIPTION DRUG LABEL 1 0071-1013 CAPSULE 50 mg ORAL NDA 33 sections
Lyrica HUMAN PRESCRIPTION DRUG LABEL 1 0071-1014 CAPSULE 75 mg ORAL NDA 33 sections
Lyrica HUMAN PRESCRIPTION DRUG LABEL 1 0071-1015 CAPSULE 100 mg ORAL NDA 33 sections
Lyrica HUMAN PRESCRIPTION DRUG LABEL 1 0071-1016 CAPSULE 150 mg ORAL NDA 33 sections
Lyrica HUMAN PRESCRIPTION DRUG LABEL 1 0071-1017 CAPSULE 200 mg ORAL NDA 33 sections
Lyrica HUMAN PRESCRIPTION DRUG LABEL 1 0071-1018 CAPSULE 300 mg ORAL NDA 33 sections
Lyrica HUMAN PRESCRIPTION DRUG LABEL 1 0071-1019 CAPSULE 225 mg ORAL NDA 33 sections
Lyrica HUMAN PRESCRIPTION DRUG LABEL 1 0071-1020 SOLUTION 20 mg ORAL NDA 33 sections
Lyrica CR HUMAN PRESCRIPTION DRUG LABEL 1 0071-1026 TABLET, FILM COATED, EXTENDED RELEASE 82.50 mg ORAL NDA 33 sections
Lyrica CR HUMAN PRESCRIPTION DRUG LABEL 1 0071-1027 TABLET, FILM COATED, EXTENDED RELEASE 165 mg ORAL NDA 33 sections
Lyrica CR HUMAN PRESCRIPTION DRUG LABEL 1 0071-1029 TABLET, FILM COATED, EXTENDED RELEASE 330 mg ORAL NDA 33 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0228-2856 CAPSULE 25 mg ORAL ANDA 28 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0228-2856 CAPSULE 25 mg ORAL ANDA 28 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0228-2856 CAPSULE 25 mg ORAL ANDA 28 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0228-2857 CAPSULE 50 mg ORAL ANDA 28 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0228-2857 CAPSULE 50 mg ORAL ANDA 28 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0228-2857 CAPSULE 50 mg ORAL ANDA 28 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0228-2858 CAPSULE 75 mg ORAL ANDA 28 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0228-2858 CAPSULE 75 mg ORAL ANDA 28 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0228-2858 CAPSULE 75 mg ORAL ANDA 28 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0228-2859 CAPSULE 100 mg ORAL ANDA 28 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0228-2859 CAPSULE 100 mg ORAL ANDA 28 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0228-2859 CAPSULE 100 mg ORAL ANDA 28 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0228-2860 CAPSULE 150 mg ORAL ANDA 28 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0228-2860 CAPSULE 150 mg ORAL ANDA 28 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0228-2860 CAPSULE 150 mg ORAL ANDA 28 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0228-2861 CAPSULE 200 mg ORAL ANDA 28 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0228-2861 CAPSULE 200 mg ORAL ANDA 28 sections
Pregabalin HUMAN PRESCRIPTION DRUG LABEL 1 0228-2861 CAPSULE 200 mg ORAL ANDA 28 sections