prednisolone tebutate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
prednisone and prednisolone derivatives	2251	7681-14-3

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

prednisolone tebutate
prednisolone tert-butylacetate
Prednisolone TBA
prednisolone butylacetate
HYDELTRA-TBA
prednisolone tertiary butylacetate

Molecular weight: 458.60
Formula: C27H38O6
CLOGP: 3.82
LIPINSKI: 0
HAC: 6
HDO: 2
TPSA: 100.90
ALOGS: -4.69
ROTB: 6

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
S (Water solubility)	0.22 mg/mL	Bocci G, Oprea TI, Benet LZ

Approvals:

Date	Agency	Company	Orphan
July 25, 1956	FDA	MERCK

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
FDA MoA	N0000175450	Corticosteroid Hormone Receptor Agonists
FDA EPC	N0000175576	Corticosteroid
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D018931	Antineoplastic Agents, Hormonal
MeSH PA	D005938	Glucocorticoids
MeSH PA	D006728	Hormones
CHEBI has role	CHEBI:35472	anti-inflammatory drugs
CHEBI has role	CHEBI:35610	antineoplastic agents
CHEBI has role	CHEBI:35703	Xenobiotic
CHEBI has role	CHEBI:35705	immunosuppressive agents
CHEBI has role	CHEBI:37962	adrenergic agents
CHEBI has role	CHEBI:49103	drug metabolites
CHEBI has role	CHEBI:78298	environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

Species	Use	Relation
Cats	Inflammation	Indication
Dogs	Inflammation	Indication
Horses	Inflammation	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Hydeltrone-TBA Suspension	Boehringer lngelheim Animal Health USA Inc.	1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	12.65	acidic
pKa2	13.36	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Glucocorticoid receptor	Nuclear hormone receptor	P04150	GCR_HUMAN	AGONIST	IC50	9.28		CHEMBL	CHEMBL
Mineralocorticoid receptor	Nuclear hormone receptor	P08235	MCR_HUMAN		Ki	9.54		CHEMBL
Androgen receptor	Nuclear hormone receptor	P10275	ANDR_HUMAN		Ki	5.60		CHEMBL
Corticosteroid-binding globulin	Secreted	P08185	CBG_HUMAN		Ki	7.51		CHEMBL
Interleukin-6	Cytokine	P05231	IL6_HUMAN		IC50	8.38		CHEMBL
G-protein coupled bile acid receptor 1	GPCR	Q8TDU6	GPBAR_HUMAN		IC50	6.60		CHEMBL
Glutamine synthetase	Enzyme	P15104	GLNA_HUMAN		EC50	7.50		CHEMBL
Disintegrin and metalloproteinase domain-containing protein 17	Unclassified	P78536	ADA17_HUMAN		IC50	7.83		CHEMBL
Progesterone receptor	Nuclear hormone receptor	P06401	PRGR_HUMAN		IC50	5.68		CHEMBL
Fatty acid-binding protein, liver	Unclassified		FABPL_RAT		Ki	5.58		CHEMBL
Glucocorticoid receptor	Transcription factor		GCR_RAT		IC50	7.28		CHEMBL
Glucocorticoid receptor	Transcription factor		GCR_MOUSE		EC50	8.47		CHEMBL

External reference:

ID	Source
4017986	VUID
N0000179220	NUI
D00982	KEGG_DRUG
4017986	VANDF
4017988	VANDF
C0071844	UMLSCUI
CHEBI:8381	CHEBI
CHEBI:8378	CHEBI
TUA	PDB_CHEM_ID
CHEMBL1200909	ChEMBL_ID
DB14632	DRUGBANK_ID
C009021	MESH_SUPPLEMENTAL_RECORD_UI
1V7A1U282K	UNII
93055	PUBCHEM_CID
DB00860	DRUGBANK_ID
34376	RXNORM
5347	MMSL
5350	MMSL
59710	MMSL
d00084	MMSL
002155	NDDF
002159	NDDF
116601002	SNOMEDCT_US
52388000	SNOMEDCT_US
96336003	SNOMEDCT_US
C0032950	UMLSCUI
CHEMBL131	ChEMBL_ID
535	INN_ID
5755	PUBCHEM_CID
D011239	MESH_DESCRIPTOR_UI

Pharmaceutical products:

None