prednisolone sulfobenzoate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| prednisone and prednisolone derivatives | 2250 | 630-67-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 0.22 mg/mL | Bocci G, Oprea TI, Benet LZ |
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Urinary retention | 69.63 | 51.94 | 22 | 716 | 30279 | 63458005 |
| Hepatocellular injury | 63.39 | 51.94 | 20 | 718 | 27361 | 63460923 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Fixed eruption | 41.02 | 39.05 | 9 | 712 | 1691 | 34954519 |
| Retinal artery occlusion | 40.10 | 39.05 | 9 | 712 | 1876 | 34954334 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hepatocellular injury | 68.09 | 35.04 | 28 | 1554 | 47565 | 79695241 |
| Cholestasis | 52.68 | 35.04 | 24 | 1558 | 52085 | 79690721 |
| Fixed eruption | 51.97 | 35.04 | 12 | 1570 | 2942 | 79739864 |
| Urinary retention | 47.72 | 35.04 | 23 | 1559 | 56607 | 79686199 |
| Retinal artery occlusion | 45.49 | 35.04 | 11 | 1571 | 3283 | 79739523 |
| Hepatic cytolysis | 42.31 | 35.04 | 17 | 1565 | 27134 | 79715672 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
| FDA EPC | N0000175576 | Corticosteroid |
| MeSH PA | D006728 | Hormones |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D018931 | Antineoplastic Agents, Hormonal |
| MeSH PA | D005938 | Glucocorticoids |
| CHEBI has role | CHEBI:35472 | anti-inflammatory drugs |
| CHEBI has role | CHEBI:35610 | antineoplastic agents |
| CHEBI has role | CHEBI:35703 | Xenobiotic |
| CHEBI has role | CHEBI:35705 | immunosuppressive agents |
| CHEBI has role | CHEBI:37962 | adrenergic agents |
| CHEBI has role | CHEBI:49103 | drug metabolites |
| CHEBI has role | CHEBI:78298 | environmental contaminants |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.78 | acidic |
| pKa2 | 13.36 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D08413 | KEGG_DRUG |
| 3694-41-5 | SECONDARY_CAS_RN |
| 4017988 | VANDF |
| CHEBI:135823 | CHEBI |
| CHEBI:8378 | CHEBI |
| TUA | PDB_CHEM_ID |
| CHEMBL2111103 | ChEMBL_ID |
| CHEMBL2107364 | ChEMBL_ID |
| 181625 | PUBCHEM_CID |
| DB00860 | DRUGBANK_ID |
| 268872 | RXNORM |
| 5347 | MMSL |
| 59710 | MMSL |
| d00084 | MMSL |
| 002155 | NDDF |
| 005522 | NDDF |
| 116601002 | SNOMEDCT_US |
| 52388000 | SNOMEDCT_US |
| 897039000 | SNOMEDCT_US |
| C0889299 | UMLSCUI |
| C0032950 | UMLSCUI |
| 535 | INN_ID |
| 5755 | PUBCHEM_CID |
| D011239 | MESH_DESCRIPTOR_UI |
| SR3YX73FW2 | UNII |
Pharmaceutical products:
None