prednisolone succinate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| prednisone and prednisolone derivatives | 2246 | 2920-86-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 0.22 mg/mL | Bocci G, Oprea TI, Benet LZ |
| CL (Clearance) | 1.46 mL/min/kg | Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Toxic epidermal necrolysis | 152.16 | 43.33 | 41 | 912 | 25293 | 63462776 |
| Stevens-Johnson syndrome | 56.16 | 43.33 | 19 | 934 | 24931 | 63463138 |
| Cholecystitis | 52.18 | 43.33 | 16 | 937 | 15361 | 63472708 |
| Lip erosion | 48.69 | 43.33 | 9 | 944 | 984 | 63487085 |
| Blister | 46.26 | 43.33 | 27 | 926 | 129787 | 63358282 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Toxic epidermal necrolysis | 132.16 | 31.66 | 49 | 2204 | 44532 | 79697603 |
| Polyneuropathy | 55.20 | 31.66 | 22 | 2231 | 24129 | 79718006 |
| Stevens-Johnson syndrome | 51.07 | 31.66 | 24 | 2229 | 39142 | 79702993 |
| Lip erosion | 44.31 | 31.66 | 10 | 2243 | 1550 | 79740585 |
| Hyperthyroidism | 39.78 | 31.66 | 17 | 2236 | 22192 | 79719943 |
| Cholecystitis | 39.77 | 31.66 | 17 | 2236 | 22195 | 79719940 |
| Respiratory disorder | 36.52 | 31.66 | 20 | 2233 | 44836 | 79697299 |
| Blister | 34.75 | 31.66 | 28 | 2225 | 119448 | 79622687 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
| FDA EPC | N0000175576 | Corticosteroid |
| MeSH PA | D005938 | Glucocorticoids |
| MeSH PA | D006728 | Hormones |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D018931 | Antineoplastic Agents, Hormonal |
| CHEBI has role | CHEBI:35472 | anti-inflammatory drugs |
| CHEBI has role | CHEBI:35610 | antineoplastic agents |
| CHEBI has role | CHEBI:35703 | Xenobiotic |
| CHEBI has role | CHEBI:35705 | immunosuppressive agents |
| CHEBI has role | CHEBI:37962 | adrenergic agents |
| CHEBI has role | CHEBI:49103 | drug metabolites |
| CHEBI has role | CHEBI:78298 | environmental contaminants |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cats | Inflammation | Indication |
| Cats | Allergy and less severe stress conditions | Indication |
| Dogs | Inflammation | Indication |
| Dogs | Allergy and less severe stress conditions | Indication |
| Dogs | Shock | Indication |
| Horses | Inflammation | Indication |
| Horses | Allergy | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Solu-Delta Cortef Sterile Powder | Zoetis Inc. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.23 | acidic |
| pKa2 | 12.65 | acidic |
| pKa3 | 13.36 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D02156 | KEGG_DRUG |
| 4017988 | VANDF |
| CHEBI:135745 | CHEBI |
| CHEBI:8378 | CHEBI |
| TUA | PDB_CHEM_ID |
| CHEMBL485659 | ChEMBL_ID |
| DB14633 | DRUGBANK_ID |
| C021322 | MESH_SUPPLEMENTAL_RECORD_UI |
| 656804 | PUBCHEM_CID |
| DB00860 | DRUGBANK_ID |
| 55063 | RXNORM |
| 5347 | MMSL |
| 59710 | MMSL |
| d00084 | MMSL |
| 002155 | NDDF |
| 002158 | NDDF |
| 006890 | NDDF |
| 116601002 | SNOMEDCT_US |
| 52388000 | SNOMEDCT_US |
| C0071840 | UMLSCUI |
| C0032950 | UMLSCUI |
| CHEMBL1412530 | ChEMBL_ID |
| 535 | INN_ID |
| 1715-33-9 | SECONDARY_CAS_RN |
| 5755 | PUBCHEM_CID |
| D011239 | MESH_DESCRIPTOR_UI |
| G7080T74ON | UNII |
Pharmaceutical products:
None