prednisolone succinate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
prednisone and prednisolone derivatives	2246	2920-86-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: prednisolone succinate prednisolone bisuccinate prednisolone hemisuccinate prednisolone sodium succinate	Molecular weight: 460.52 Formula: C25H32O8 CLOGP: 1.73 LIPINSKI: 0 HAC: 8 HDO: 3 TPSA: 138.20 ALOGS: -3.98 ROTB: 7 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

prednisolone succinate
prednisolone bisuccinate
prednisolone hemisuccinate
prednisolone sodium succinate

Molecular weight: 460.52
Formula: C25H32O8
CLOGP: 1.73
LIPINSKI: 0
HAC: 8
HDO: 3
TPSA: 138.20
ALOGS: -3.98
ROTB: 7

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

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Property	Value	Reference
CL (Clearance)	1.46 mL/min/kg	Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K
S (Water solubility)	0.22 mg/mL	Bocci G, Oprea TI, Benet LZ

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Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxic epidermal necrolysis	152.16	43.33	41	912	25293	63462776
Stevens-Johnson syndrome	56.16	43.33	19	934	24931	63463138
Cholecystitis	52.18	43.33	16	937	15361	63472708
Lip erosion	48.69	43.33	9	944	984	63487085
Blister	46.26	43.33	27	926	129787	63358282

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FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxic epidermal necrolysis	132.16	31.66	49	2204	44532	79697603
Polyneuropathy	55.20	31.66	22	2231	24129	79718006
Stevens-Johnson syndrome	51.07	31.66	24	2229	39142	79702993
Lip erosion	44.31	31.66	10	2243	1550	79740585
Hyperthyroidism	39.78	31.66	17	2236	22192	79719943
Cholecystitis	39.77	31.66	17	2236	22195	79719940
Respiratory disorder	36.52	31.66	20	2233	44836	79697299
Blister	34.75	31.66	28	2225	119448	79622687

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
CHEBI has role	CHEBI:35472	anti-inflammatory drugs
CHEBI has role	CHEBI:35610	antineoplastic agents
CHEBI has role	CHEBI:35703	Xenobiotic
CHEBI has role	CHEBI:35705	immunosuppressive agents
CHEBI has role	CHEBI:37962	adrenergic agents
CHEBI has role	CHEBI:49103	drug metabolites
CHEBI has role	CHEBI:78298	environmental contaminants
FDA EPC	N0000175576	Corticosteroid
FDA MoA	N0000175450	Corticosteroid Hormone Receptor Agonists
MeSH PA	D005938	Glucocorticoids

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Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

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Species	Use	Relation
Cats	Inflammation	Indication
Cats	Allergy and less severe stress conditions	Indication
Dogs	Inflammation	Indication
Dogs	Allergy and less severe stress conditions	Indication
Dogs	Shock	Indication
Horses	Inflammation	Indication
Horses	Allergy	Indication

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🐶 Veterinary products

Product	Applicant	Ingredients
Solu-Delta Cortef Sterile Powder	Zoetis Inc.	1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.23	acidic
pKa2	12.65	acidic
pKa3	13.36	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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ID	Source
TUA	PDB_CHEM_ID
002155	NDDF
002158	NDDF
006890	NDDF
116601002	SNOMEDCT_US
1715-33-9	SECONDARY_CAS_RN
4017988	VANDF
52388000	SNOMEDCT_US
5347	MMSL
535	INN_ID

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Pharmaceutical products:

None