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prednicarbate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| prednisone and prednisolone derivatives | 2243 | 73771-04-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 0.22 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BA (Bioavailability) | 82 % |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,MAP3K7,MAPK10,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKDC,STK33,SYK,TEK,TTK,ZAP70 | 36 | |||
| kinase-selectivity-class | AXL,GRK2,MAP2K6,STK33,TEK | 5 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Sept. 23, 1991 | FDA | VALEANT PHARMS NORTH |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Blepharospasm | 96.57 | 24.64 | 44 | 3053 | 55401 | 90569949 |
| Taste disorder | 89.14 | 24.64 | 43 | 3054 | 61503 | 90563847 |
| Epilepsy | 80.14 | 24.64 | 44 | 3053 | 82162 | 90543188 |
| Gastrooesophageal reflux disease | 51.97 | 24.64 | 44 | 3053 | 166293 | 90459057 |
| Memory impairment | 47.41 | 24.64 | 45 | 3052 | 197199 | 90428151 |
| Migraine | 46.84 | 24.64 | 44 | 3053 | 190348 | 90435002 |
| Paraesthesia | 38.48 | 24.64 | 45 | 3052 | 250281 | 90375069 |
| Ecthyma | 36.45 | 24.64 | 7 | 3090 | 407 | 90624943 |
| Abdominal pain upper | 35.67 | 24.64 | 50 | 3047 | 332624 | 90292726 |
| Autoimmune dermatitis | 29.04 | 24.64 | 5 | 3092 | 157 | 90625193 |
| Hypoaesthesia | 28.98 | 24.64 | 44 | 3053 | 314166 | 90311184 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Blepharospasm | 99.34 | 26.40 | 44 | 3530 | 54807 | 110530918 |
| Taste disorder | 95.00 | 26.40 | 45 | 3529 | 65342 | 110520383 |
| Epilepsy | 76.90 | 26.40 | 45 | 3529 | 100164 | 110485561 |
| Gastrooesophageal reflux disease | 53.10 | 26.40 | 45 | 3529 | 179931 | 110405794 |
| Migraine | 52.87 | 26.40 | 44 | 3530 | 171608 | 110414117 |
| Memory impairment | 47.63 | 26.40 | 44 | 3530 | 196900 | 110388825 |
| Abdominal pain upper | 35.93 | 26.40 | 50 | 3524 | 349061 | 110236664 |
| Paraesthesia | 35.25 | 26.40 | 44 | 3530 | 276477 | 110309248 |
| Wound infection | 32.34 | 26.40 | 26 | 3548 | 96439 | 110489286 |
| Hypoaesthesia | 30.83 | 26.40 | 44 | 3530 | 314179 | 110271546 |
| Ecthyma | 30.42 | 26.40 | 7 | 3567 | 1032 | 110584693 |
| Rheumatic fever | 28.86 | 26.40 | 27 | 3547 | 122552 | 110463173 |
| Autoimmune dermatitis | 27.46 | 26.40 | 5 | 3569 | 230 | 110585495 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D07AC18 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, potent (group III) |
| FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
| FDA EPC | N0000175576 | Corticosteroid |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D005938 | Glucocorticoids |
| MeSH PA | D006728 | Hormones |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D018931 | Antineoplastic Agents, Hormonal |
| CHEBI has role | CHEBI:22587 | antiviral agent |
| CHEBI has role | CHEBI:33231 | antitubercular agent |
| CHEBI has role | CHEBI:33281 | antimicrobial agent |
| CHEBI has role | CHEBI:35441 | antiinfective agent |
| CHEBI has role | CHEBI:35472 | anti-inflammatory drug |
| CHEBI has role | CHEBI:35476 | antipsychotic agent |
| CHEBI has role | CHEBI:35526 | hypoglycemic agent |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:35674 | antihypertensive agent |
| CHEBI has role | CHEBI:35703 | xenobiotic |
| CHEBI has role | CHEBI:35705 | immunosuppressive agent |
| CHEBI has role | CHEBI:35816 | leprostatic drug |
| CHEBI has role | CHEBI:35842 | antirheumatic drug |
| CHEBI has role | CHEBI:37962 | adrenergic agent |
| CHEBI has role | CHEBI:39456 | antiglaucoma drug |
| CHEBI has role | CHEBI:49103 | drug metabolite |
| CHEBI has role | CHEBI:49201 | anti-ulcer drug |
| CHEBI has role | CHEBI:50177 | dermatologic drug |
| CHEBI has role | CHEBI:50671 | antithyroid drug |
| CHEBI has role | CHEBI:50748 | antipsoriatic |
| CHEBI has role | CHEBI:53784 | antispasmodic drug |
| CHEBI has role | CHEBI:64946 | anti-HIV agent |
| CHEBI has role | CHEBI:65023 | anti-asthmatic agent |
| CHEBI has role | CHEBI:66981 | ophthalmology drug |
| CHEBI has role | CHEBI:67079 | anti-inflammatory agent |
| CHEBI has role | CHEBI:75835 | anti-anaemic agent |
| CHEBI has role | CHEBI:76595 | nephroprotective agent |
| CHEBI has role | CHEBI:77715 | nasal decongestant |
| CHEBI has role | CHEBI:78298 | environmental contaminant |
| CHEBI has role | CHEBI:231911 | renoprotective agent |
| CHEBI has role | CHEBI:233423 | antifibrotic agent |
| CHEBI has role | CHEBI:35718 | antifungal agent |
| CHEBI has role | CHEBI:86327 | antifungal drug |
Related Drugs by ATC class:
D07AC Corticosteroids, potent (group III) 20 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Atopic dermatitis | indication | 24079001 | DOID:3310 |
| Contact dermatitis | indication | 40275004 | DOID:2773 |
| Seborrheic dermatitis | indication | 50563003 | DOID:8741 |
| Lichen simplex chronicus | indication | 53891004 | |
| Granuloma annulare | indication | 65508009 | DOID:3777 |
| Pruritus ani | indication | 90446007 | |
| Discoid lupus erythematosus | indication | 200938002 | |
| Plaque psoriasis | indication | 200965009 | |
| Scalp psoriasis | indication | 238608008 | |
| Pruritus of genital organs | indication | 267802000 | |
| Eruption of skin | indication | 271807003 | DOID:0050486 |
| Primary cutaneous T-cell lymphoma | indication | 400122007 | |
| Telangiectasia disorder | contraindication | 247479008 | |
| Adrenal cortical hypofunction | contraindication | 386584007 | DOID:10493 |
| Atrophoderma | contraindication | 399979006 | |
| Peripheral vascular disease | contraindication | 400047006 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.19 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4020905 | VUID |
| N0000148395 | NUI |
| D05601 | KEGG_DRUG |
| 4017988 | VANDF |
| 4020905 | VANDF |
| C0071836 | UMLSCUI |
| CHEBI:135791 | CHEBI |
| TUA | PDB_CHEM_ID |
| CHEMBL1200386 | ChEMBL_ID |
| DB01130 | DRUGBANK_ID |
| C035287 | MESH_SUPPLEMENTAL_RECORD_UI |
| 7605 | IUPHAR_LIGAND_ID |
| 4968 | INN_ID |
| V901LV1K7D | UNII |
| 6714002 | PUBCHEM_CID |
| 34369 | RXNORM |
| 5346 | MMSL |
| 5347 | MMSL |
| 59710 | MMSL |
| 89095 | MMSL |
| d00084 | MMSL |
| 002155 | NDDF |
| 004400 | NDDF |
| 116601002 | SNOMEDCT_US |
| 126086006 | SNOMEDCT_US |
| 415158006 | SNOMEDCT_US |
| 52388000 | SNOMEDCT_US |
| C0032950 | UMLSCUI |
| DB00860 | DRUGBANK_ID |
| 5755 | PUBCHEM_CID |
| 535 | INN_ID |
| D011239 | MESH_DESCRIPTOR_UI |
| CHEBI:8378 | CHEBI |
| V901LV1K7D | INXIGHT DRUGS |
Pharmaceutical products:
None