prednicarbate Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 2243 73771-04-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • prednicarbate
  • prednitop
  • Molecular weight: 488.58
  • Formula: C27H36O8
  • CLOGP: 3.50
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 1
  • TPSA: 116.20
  • ALOGS: -4.94
  • ROTB: 9

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 23, 1991 FDA VALEANT PHARMS NORTH

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC D07AC18 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, potent (group III)
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Atopic dermatitis indication 24079001 DOID:3310
Contact dermatitis indication 40275004 DOID:2773
Seborrheic dermatitis indication 50563003 DOID:8741
Lichen simplex chronicus indication 53891004
Granuloma annulare indication 65508009 DOID:3777
Pruritus ani indication 90446007
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Scalp psoriasis indication 238608008
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Primary cutaneous T-cell lymphoma indication 400122007
Telangiectasia disorder contraindication 247479008
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.19 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST CHEMBL CHEMBL

External reference:

IDSource
4020905 VUID
N0000148395 NUI
D05601 KEGG_DRUG
4020905 VANDF
C0071836 UMLSCUI
CHEBI:135791 CHEBI
CHEMBL1200386 ChEMBL_ID
DB01130 DRUGBANK_ID
7605 IUPHAR_LIGAND_ID
C035287 MESH_SUPPLEMENTAL_RECORD_UI
4968 INN_ID
V901LV1K7D UNII
52421 PUBCHEM_CID
34369 RXNORM
5346 MMSL
89095 MMSL
004400 NDDF
126086006 SNOMEDCT_US
415158006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Prednicarbate HUMAN PRESCRIPTION DRUG LABEL 1 0168-0381 CREAM 1 mg TOPICAL ANDA 20 sections
Prednicarbate HUMAN PRESCRIPTION DRUG LABEL 1 0168-0410 OINTMENT 1 mg TOPICAL ANDA 20 sections