DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
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L1000
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
prednicarbate 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
prednisone and prednisolone derivatives
2243
73771-04-7
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
prednicarbate
prednitop
Molecular weight: 488.58
Formula: C27H36O8
CLOGP: 3.50
LIPINSKI: 0
HAC: 8
HDO: 1
TPSA: 116.20
ALOGS: -4.94
ROTB: 9
Status: OFP
Legend:
OFP - off patent
OFM - off market
ONP - on patent
Drug dosage:
None
ADMET properties:
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Property
Value
Reference
S (Water solubility)
0.22 mg/mL
Bocci G, Oprea TI, Benet LZ
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Approvals:
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Date
Agency
Company
Orphan
Sept. 23, 1991
FDA
VALEANT PHARMS NORTH
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FDA Adverse Event Reporting System (Female)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Ecthyma
52.66
51.38
7
293
291
63488431
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FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
D07AC18
DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, potent (group III)
CHEBI has role
CHEBI:35472
anti-inflammatory drugs
CHEBI has role
CHEBI:35610
antineoplastic agents
CHEBI has role
CHEBI:35703
Xenobiotic
CHEBI has role
CHEBI:35705
immunosuppressive agents
CHEBI has role
CHEBI:37962
adrenergic agents
CHEBI has role
CHEBI:49103
drug metabolites
CHEBI has role
CHEBI:78298
environmental contaminants
FDA EPC
N0000175576
Corticosteroid
FDA MoA
N0000175450
Corticosteroid Hormone Receptor Agonists
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Atopic dermatitis
indication
24079001
DOID:3310
Contact dermatitis
indication
40275004
DOID:2773
Seborrheic dermatitis
indication
50563003
DOID:8741
Lichen simplex chronicus
indication
53891004
Granuloma annulare
indication
65508009
DOID:3777
Pruritus ani
indication
90446007
Discoid lupus erythematosus
indication
200938002
Plaque psoriasis
indication
200965009
Scalp psoriasis
indication
238608008
Pruritus of genital organs
indication
267802000
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
13.19
acidic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Glucocorticoid receptor
Nuclear hormone receptor
P04150
GCR_HUMAN
AGONIST
CHEMBL
CHEMBL
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External reference:
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ID
Source
TUA
PDB_CHEM_ID
002155
NDDF
004400
NDDF
116601002
SNOMEDCT_US
126086006
SNOMEDCT_US
34369
RXNORM
4017988
VANDF
4020905
VUID
4020905
VANDF
415158006
SNOMEDCT_US
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Pharmaceutical products:
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Product
Category
Ingredients
NDC
Form
Quantity
Route
Marketing
Label
Prednicarbate
HUMAN PRESCRIPTION DRUG LABEL
1
0168-0410
OINTMENT
1 mg
TOPICAL
ANDA
20 sections
Prednicarbate
HUMAN PRESCRIPTION DRUG LABEL
1
0168-0410
OINTMENT
1 mg
TOPICAL
ANDA
20 sections
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prednicarbate