prazepam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
diazepam derivatives	2240	2955-38-6

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: prazepam sedapran trepidan verstran prazene	A benzodiazepine that is used in the treatment of ANXIETY DISORDERS. Molecular weight: 324.81 Formula: C19H17ClN2O CLOGP: 3.93 LIPINSKI: 0 HAC: 3 HDO: 0 TPSA: 32.67 ALOGS: -4.91 ROTB: 3 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

prazepam
sedapran
trepidan
verstran
prazene

A benzodiazepine that is used in the treatment of ANXIETY DISORDERS.

Molecular weight: 324.81
Formula: C19H17ClN2O
CLOGP: 3.93
LIPINSKI: 0
HAC: 3
HDO: 0
TPSA: 32.67
ALOGS: -4.91
ROTB: 3

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
30	mg	O

ADMET properties:

Show entries

Search:

Property	Value	Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)	3.08 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.00 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0 %	Benet LZ, Broccatelli F, Oprea TI

Showing 1 to 4 of 4 entries

Previous1Next

Approvals:

Date	Agency	Company	Orphan
None	FDA	PARKE DAVIS

FDA Adverse Event Reporting System (Female)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Poisoning deliberate	394.06	37.57	99	3827	11119	63473977
Coma	311.74	37.57	125	3801	64239	63420857
Somnolence	181.21	37.57	121	3805	178564	63306532
Drug abuse	135.75	37.57	73	3853	72445	63412651
Altered state of consciousness	132.22	37.57	52	3874	25178	63459918
Suicide attempt	118.68	37.57	63	3863	60855	63424241
Intentional overdose	117.77	37.57	67	3859	74085	63411011
Drug dependence	102.63	37.57	43	3883	24440	63460656
Mydriasis	97.05	37.57	34	3892	11922	63473174
Toxicity to various agents	90.97	37.57	93	3833	247157	63237939

Showing 1 to 10 of 26 entries

Previous1 2 3Next

FDA Adverse Event Reporting System (Male)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Coma	212.71	35.76	84	1894	45594	34909359
Miosis	116.08	35.76	36	1942	9499	34945454
Somnolence	86.98	35.76	62	1916	111054	34843899
Drug abuse	81.47	35.76	57	1921	99039	34855914
Poisoning deliberate	80.44	35.76	26	1952	7818	34947135
Housebound	76.40	35.76	13	1965	225	34954728
Pneumonia aspiration	53.87	35.76	32	1946	41871	34913082
Bladder dilatation	47.60	35.76	12	1966	1480	34953473
Intentional overdose	40.18	35.76	27	1951	43647	34911306
Suicide attempt	37.96	35.76	25	1953	39091	34915862

Showing 1 to 10 of 11 entries

Previous1 2Next

FDA Adverse Event Reporting System (Geriatric)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Coma	491.92	29.65	207	5699	100442	79638040
Poisoning deliberate	435.16	29.65	124	5782	18704	79719778
Somnolence	259.81	29.65	181	5725	238800	79499682
Miosis	165.97	29.65	57	5849	15732	79722750
Altered state of consciousness	154.80	29.65	72	5834	43750	79694732
Suicide attempt	152.98	29.65	88	5818	82844	79655638
Drug abuse	146.13	29.65	110	5796	162581	79575901
Intentional overdose	135.54	29.65	89	5817	105871	79632611
Mydriasis	115.73	29.65	45	5861	17598	79720884
Hepatocellular injury	94.39	29.65	53	5853	47540	79690942

Showing 1 to 10 of 39 entries

Previous1 2 3 4Next

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Show entries

Search:

Source	Code	Description
ATC	N05BA11	NERVOUS SYSTEM PSYCHOLEPTICS ANXIOLYTICS Benzodiazepine derivatives
MeSH PA	D014151	Anti-Anxiety Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D018682	GABA Agents
MeSH PA	D018757	GABA Modulators
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D014149	Tranquilizing Agents

Showing 1 to 9 of 9 entries

Previous1Next

Drug Use | Suggest Off label Use Form| |View source of the data|

Show entries

Search:

Disease	Relation	SNOMED_ID	DOID
Anxiety	indication	48694002
Insomnia	indication	193462001
Suicidal thoughts	contraindication	6471006
Disorder of lung	contraindication	19829001	DOID:850
Borderline personality disorder	contraindication	20010003	DOID:10930
Alcohol intoxication	contraindication	25702006
Shock	contraindication	27942005
Depressive disorder	contraindication	35489007
Substance abuse	contraindication	66214007
Psychotic disorder	contraindication	69322001

Showing 1 to 10 of 20 entries

Previous1 2Next

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	2.89	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Show entries

Search:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
GABA-A receptor alpha-1/beta-2/gamma-2	Ion channel	P14867 P18507 P47870	GBRA1_HUMAN GBRG2_HUMAN GBRB2_HUMAN	POSITIVE ALLOSTERIC MODULATOR				WOMBAT-PK	CHEMBL

Showing 1 to 1 of 1 entries

Previous1Next

External reference:

Show entries

Search:

ID	Source
001459	NDDF
1727	INN_ID
387417001	SNOMEDCT_US
4018633	VUID
4018633	VANDF
4890	PUBCHEM_CID
7275	IUPHAR_LIGAND_ID
74065006	SNOMEDCT_US
8627	RXNORM
C0032910	UMLSCUI

Showing 1 to 10 of 17 entries

Previous1 2Next

Pharmaceutical products:

None