pranoprofen Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibuprofen derivatives 2238 52549-17-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pranoprofen
  • niflan
  • oftalar
  • dl-Pranoprofen
  • Molecular weight: 255.27
  • Formula: C15H13NO3
  • CLOGP: 2.49
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 59.42
  • ALOGS: -2.39
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC S01BC09 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Antiinflammatory agents, non-steroids
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D006074 Gout Suppressants
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.34 acidic
pKa2 5.55 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 1 Enzyme IC50 5.51 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 6.41 CHEMBL

External reference:

IDSource
D01578 KEGG_DRUG
C0072652 UMLSCUI
CHEBI:32040 CHEBI
CHEMBL367463 ChEMBL_ID
DB13514 DRUGBANK_ID
4298 INN_ID
4888 PUBCHEM_CID
C043940 MESH_SUPPLEMENTAL_RECORD_UI
2R7O1ET613 UNII
009072 NDDF
713470006 SNOMEDCT_US

Pharmaceutical products:

None