Stem definition | Drug id | CAS RN |
---|---|---|
leukotriene receptor antagonists | 2237 | 103177-37-3 |
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
March 15, 2007 | PMDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Asthma | 37.56 | 31.16 | 18 | 479 | 89319 | 50515308 |
None
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hepatic function abnormal | 41.45 | 26.01 | 21 | 1125 | 64292 | 64433294 |
Asthma | 33.75 | 26.01 | 21 | 1125 | 95204 | 64402382 |
Pyrexia | 27.51 | 26.01 | 41 | 1105 | 558603 | 63938983 |
None
Source | Code | Description |
---|---|---|
ATC | R03DC02 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES Leukotriene receptor antagonists |
MeSH PA | D018927 | Anti-Asthmatic Agents |
MeSH PA | D006727 | Hormone Antagonists |
MeSH PA | D020024 | Leukotriene Antagonists |
MeSH PA | D019141 | Respiratory System Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Allergic rhinitis | indication | 61582004 | |
Asthma | indication | 195967001 | DOID:2841 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 5.55 | acidic |
pKa2 | 10.08 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Cysteinyl leukotriene receptor 1 | GPCR | ANTAGONIST | IC50 | 10 | IUPHAR | SCIENTIFIC LITERATURE | |||
Cysteinyl leukotriene receptor 2 | GPCR | ANTAGONIST | IC50 | 5.44 | IUPHAR | ||||
Bile acid receptor | Nuclear hormone receptor | EC50 | 4.82 | CHEMBL | |||||
Uracil nucleotide/cysteinyl leukotriene receptor | GPCR | Ki | 5.39 | CHEMBL | |||||
Cysteinyl leukotriene receptor 1 | GPCR | Ki | 9.10 | CHEMBL | |||||
Replicase polyprotein 1ab | Unclassified | Kd | 4.85 | CHEMBL | |||||
Cruzipain | Enzyme | IC50 | 5.15 | CHEMBL |
ID | Source |
---|---|
D02732 | KEGG_DRUG |
C0526058 | UMLSCUI |
CHEBI:94810 | CHEBI |
KNT | PDB_CHEM_ID |
CHEMBL21333 | ChEMBL_ID |
CHEMBL11350 | ChEMBL_ID |
DB01411 | DRUGBANK_ID |
C047681 | MESH_SUPPLEMENTAL_RECORD_UI |
3634 | IUPHAR_LIGAND_ID |
6943 | INN_ID |
TB8Z891092 | UNII |
4887 | PUBCHEM_CID |
713438006 | SNOMEDCT_US |
None