pranlukast Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| leukotriene receptor antagonists | 2237 | 103177-37-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
SRS-A antagonist; leukotriene D4 receptor antagonist
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| March 15, 2007 | PMDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Asthma | 100.43 | 31.59 | 47 | 1021 | 108925 | 53239073 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Asthma | 89.59 | 28.39 | 39 | 1086 | 44026 | 32468375 |
| Eosinophilic granulomatosis with polyangiitis | 48.08 | 28.39 | 11 | 1114 | 1481 | 32510920 |
| Hepatic function abnormal | 35.43 | 28.39 | 21 | 1104 | 44819 | 32467582 |
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | R03DC02 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES Leukotriene receptor antagonists |
| MeSH PA | D018927 | Anti-Asthmatic Agents |
| MeSH PA | D006727 | Hormone Antagonists |
| MeSH PA | D020024 | Leukotriene Antagonists |
| MeSH PA | D019141 | Respiratory System Agents |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Allergic rhinitis | indication | 61582004 | |
| Asthma | indication | 195967001 | DOID:2841 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 5.55 | acidic |
| pKa2 | 10.08 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Cysteinyl leukotriene receptor 1 | GPCR | ANTAGONIST | IC50 | 10 | IUPHAR | SCIENTIFIC LITERATURE | |||
| Cysteinyl leukotriene receptor 2 | GPCR | ANTAGONIST | IC50 | 5.44 | IUPHAR | ||||
| Bile acid receptor | Nuclear hormone receptor | EC50 | 4.82 | CHEMBL | |||||
| Uracil nucleotide/cysteinyl leukotriene receptor | GPCR | Ki | 5.39 | CHEMBL | |||||
| Cysteinyl leukotriene receptor 1 | GPCR | Ki | 9.10 | CHEMBL | |||||
| Replicase polyprotein 1ab | Unclassified | Kd | 4.85 | CHEMBL | |||||
| Cruzipain | Enzyme | IC50 | 5.15 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D02732 | KEGG_DRUG |
| C0526058 | UMLSCUI |
| CHEBI:94810 | CHEBI |
| KNT | PDB_CHEM_ID |
| CHEMBL21333 | ChEMBL_ID |
| CHEMBL11350 | ChEMBL_ID |
| DB01411 | DRUGBANK_ID |
| C047681 | MESH_SUPPLEMENTAL_RECORD_UI |
| 3634 | IUPHAR_LIGAND_ID |
| 6943 | INN_ID |
| TB8Z891092 | UNII |
| 4887 | PUBCHEM_CID |
| 713438006 | SNOMEDCT_US |
Pharmaceutical products:
None