pramipexole ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2233 104632-26-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pramipexole hydrochloride
  • pramipexole hydrochloride hydrate
  • sifrol
  • oprymea
  • pramipexole
  • (S)-Pramipexole
  • mirapexin
  • pramipexole dihydrochloride
  • pramipexole dihydrochloride monohydrate
  • pramipexole HCl
  • pramipexol dihydrobromide
A dopamine agonist that binds with high selectivity and specificity to the D2 subfamily of dopamine receptors of which it has a preferential affinity to D3 receptors, and has full intrinsic activity. Pramipexole alleviates parkinsonian motor deficits by stimulation of dopamine receptors in the striatum. Animal studies have shown that pramipexole inhibits dopamine synthesis, release, and turnover.
  • Molecular weight: 211.33
  • Formula: C10H17N3S
  • CLOGP: 1.47
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 50.94
  • ALOGS: -3.18
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2.50 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.20 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 90 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.30 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 93 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 7 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7.20 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.85 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 12.40 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 1, 1997 FDA BOEHRINGER INGELHEIM

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gambling disorder 476.44 11.68 115 31346 1096 56259510
Dyskinesia 393.58 11.68 229 31232 28879 56231727
Restless legs syndrome 319.24 11.68 166 31295 16781 56243825
Impulse-control disorder 312.05 11.68 74 31387 649 56259957
Compulsive shopping 296.08 11.68 71 31390 656 56259950
On and off phenomenon 270.39 11.68 78 31383 1546 56259060
Hallucination 233.00 11.68 204 31257 48945 56211661
Hallucination, visual 173.65 11.68 113 31348 17355 56243251
Gambling 153.93 11.68 34 31427 209 56260397
Parkinsonism hyperpyrexia syndrome 131.45 11.68 27 31434 110 56260496
Dystonia 127.50 11.68 82 31379 12339 56248267
Tremor 123.17 11.68 233 31228 120856 56139750
Hypersexuality 116.72 11.68 31 31430 446 56260160
Freezing phenomenon 114.68 11.68 37 31424 1080 56259526
Stoma site discharge 106.43 11.68 37 31424 1365 56259241
Muscle rigidity 93.90 11.68 64 31397 10607 56249999
Pleurothotonus 93.15 11.68 33 31428 1288 56259318
Stoma site erythema 93.11 11.68 31 31430 1001 56259605
Bradykinesia 92.66 11.68 48 31413 4806 56255800
Obsessive-compulsive disorder 92.57 11.68 44 31417 3662 56256944
Sudden onset of sleep 89.56 11.68 26 31435 527 56260079
Systemic lupus erythematosus 87.26 11.68 3 31458 180075 56080531
Stoma site pain 85.80 11.68 28 31433 848 56259758
Stereotypy 82.59 11.68 23 31438 399 56260207
Binge eating 73.56 11.68 21 31440 400 56260206
Camptocormia 70.99 11.68 19 31442 282 56260324
Fall 70.54 11.68 389 31072 357121 55903485
Orthostatic hypotension 66.06 11.68 87 31374 33112 56227494
Jealous delusion 63.45 11.68 12 31449 28 56260578
Glossodynia 63.39 11.68 6 31455 152452 56108154
Maternal exposure during pregnancy 57.96 11.68 17 31444 189536 56071070
Hyperkinesia 55.30 11.68 24 31437 1615 56258991
Therapeutic response shortened 54.85 11.68 44 31417 9342 56251264
Delusion 53.99 11.68 47 31414 11168 56249438
Parkinson's disease 53.06 11.68 22 31439 1322 56259284
Compulsive hoarding 52.58 11.68 11 31450 50 56260556
Rheumatoid arthritis 51.62 11.68 84 31377 382520 55878086
Psychotic disorder 50.41 11.68 64 31397 23494 56237112
Acute psychosis 50.37 11.68 25 31436 2287 56258319
Pericarditis 48.90 11.68 3 31458 108920 56151686
Drug dispensed to wrong patient 48.19 11.68 13 31448 199 56260407
Hand deformity 47.13 11.68 9 31452 134483 56126123
Torticollis 47.08 11.68 22 31439 1761 56258845
Diabetes mellitus inadequate control 46.98 11.68 48 31413 13932 56246674
Alopecia 45.90 11.68 58 31403 293400 55967206
Abnormal dreams 45.57 11.68 40 31421 9609 56250997
Neuroleptic malignant syndrome 45.25 11.68 43 31418 11435 56249171
Somnolence 45.18 11.68 196 31265 163217 56097389
Contraindicated product administered 43.55 11.68 25 31436 186261 56074345
Gait disturbance 41.46 11.68 191 31270 163130 56097476
Abnormal behaviour 40.13 11.68 53 31408 20219 56240387
Parkinsonism 40.01 11.68 37 31424 9509 56251097
Medication error 38.75 11.68 78 31383 42257 56218349
Vestibular migraine 38.07 11.68 11 31450 219 56260387
Sleep attacks 38.04 11.68 9 31452 78 56260528
Akinesia 37.64 11.68 18 31443 1518 56259088
Febrile neutropenia 37.11 11.68 7 31454 105538 56155068
Stoma site infection 36.15 11.68 14 31447 703 56259903
Discomfort 36.13 11.68 17 31444 141744 56118862
Psychomotor hyperactivity 35.35 11.68 35 31426 9785 56250821
Total lung capacity decreased 35.12 11.68 17 31444 1472 56259134
Dependence 33.17 11.68 18 31443 1979 56258627
Bronchopulmonary aspergillosis allergic 32.58 11.68 16 31445 1430 56259176
Multiple drug therapy 32.58 11.68 20 31441 2772 56257834
Blood pressure inadequately controlled 32.55 11.68 24 31437 4500 56256106
Pituitary haemorrhage 32.18 11.68 8 31453 87 56260519
Insomnia 32.04 11.68 200 31261 191660 56068946
Swelling 31.95 11.68 53 31408 239718 56020888
Dopamine dysregulation syndrome 31.75 11.68 9 31452 167 56260439
Dropped head syndrome 31.08 11.68 8 31453 101 56260505
Malignant polyp 31.07 11.68 9 31452 181 56260425
Anxiety 30.79 11.68 199 31262 192973 56067633
Lung opacity 30.50 11.68 18 31443 2323 56258283
Drug intolerance 29.63 11.68 65 31396 264753 55995853
Synovitis 29.47 11.68 28 31433 161277 56099329
Delirium 29.42 11.68 70 31391 42447 56218159
Rash 28.79 11.68 160 31301 492887 55767719
Fibroma 28.55 11.68 12 31449 746 56259860
Economic problem 28.38 11.68 16 31445 1895 56258711
Abdominal discomfort 27.89 11.68 72 31389 277202 55983404
Exercise tolerance decreased 27.73 11.68 23 31438 5115 56255491
Memory impairment 27.17 11.68 108 31353 86449 56174157
Neutropenia 27.13 11.68 29 31432 158138 56102468
Joint swelling 27.09 11.68 78 31383 289722 55970884
Product prescribing error 26.53 11.68 47 31414 23139 56237467
Depressed mood 26.40 11.68 61 31400 36298 56224308
Hypersensitivity 26.23 11.68 66 31395 256342 56004264
Hyperventilation 25.84 11.68 23 31438 5625 56254981
Crime 25.53 11.68 5 31456 15 56260591
Hyperphagia 25.44 11.68 14 31447 1582 56259024
Exposure during pregnancy 24.52 11.68 24 31437 136318 56124288
Orthostatic intolerance 24.39 11.68 12 31449 1077 56259529
Oedema peripheral 24.04 11.68 171 31290 171083 56089523
Posture abnormal 23.77 11.68 15 31446 2183 56258423
Malignant neoplasm progression 23.60 11.68 6 31455 73581 56187025
Amnesia 23.58 11.68 68 31393 46254 56214352
Deep brain stimulation 23.19 11.68 5 31456 27 56260579
Cognitive disorder 22.99 11.68 70 31391 49063 56211543
Drug interaction 22.07 11.68 196 31265 209559 56051047
Vaccination site oedema 21.92 11.68 4 31457 7 56260599
Withdrawal syndrome 21.87 11.68 38 31423 18424 56242182
Nightmare 21.74 11.68 36 31425 16790 56243816
Compulsions 21.61 11.68 7 31454 207 56260399
Vaccination site bruising 21.57 11.68 4 31457 8 56260598
Vaccination site pruritus 21.57 11.68 4 31457 8 56260598
Chorea 21.45 11.68 12 31449 1400 56259206
Snoring 21.37 11.68 17 31444 3564 56257042
Stomatitis 20.88 11.68 22 31439 120788 56139818
Restlessness 20.86 11.68 46 31415 26540 56234066
Movement disorder 20.80 11.68 38 31423 19160 56241446
Diarrhoea 20.69 11.68 243 31218 638264 55622342
Pulmonary fibrosis 20.59 11.68 49 31412 29709 56230897
Therapeutic response changed 20.58 11.68 10 31451 873 56259733
Stoma site inflammation 20.48 11.68 8 31453 411 56260195
Sleep apnoea syndrome 20.34 11.68 45 31416 26016 56234590
Female orgasmic disorder 20.14 11.68 5 31456 54 56260552
Blister 19.77 11.68 19 31442 108868 56151738
Muscle injury 19.51 11.68 3 31458 52497 56208109
Drug withdrawal syndrome 19.46 11.68 44 31417 25813 56234793
Stoma site hypergranulation 19.29 11.68 7 31454 293 56260313
Off label use 19.05 11.68 209 31252 555971 55704635
Heat stroke 18.98 11.68 9 31452 745 56259861
Serum serotonin increased 18.90 11.68 6 31455 166 56260440
Prescribed underdose 18.88 11.68 38 31423 20579 56240027
Aspiration 18.80 11.68 25 31436 9596 56251010
Blood calcium increased 18.80 11.68 23 31438 8131 56252475
Coronary artery dissection 18.72 11.68 9 31452 768 56259838
Product substitution issue 18.55 11.68 31 31430 14568 56246038
Toxicity to various agents 18.46 11.68 64 31397 224500 56036106
Product residue present 18.46 11.68 16 31445 3779 56256827
Depression 18.27 11.68 167 31294 179950 56080656
Suspiciousness 18.18 11.68 7 31454 346 56260260
Inhibitory drug interaction 18.15 11.68 13 31448 2331 56258275
Therapeutic product effect variable 18.14 11.68 10 31451 1134 56259472
Orgasm abnormal 18.10 11.68 5 31456 84 56260522
Treatment failure 18.08 11.68 43 31418 170349 56090257
Ill-defined disorder 17.79 11.68 8 31453 68535 56192071
Stoma site irritation 17.29 11.68 6 31455 220 56260386
Wound 17.27 11.68 32 31429 138772 56121834
Pre-existing condition improved 17.27 11.68 21 31440 7377 56253229
Conjunctival discolouration 17.05 11.68 5 31456 105 56260501
Stoma site reaction 17.04 11.68 6 31455 230 56260376
Narcolepsy 16.88 11.68 10 31451 1299 56259307
Meningorrhagia 16.88 11.68 5 31456 109 56260497
Bipolar disorder 16.86 11.68 21 31440 7559 56253047
Pancytopenia 16.67 11.68 15 31446 88700 56171906
Suicidal ideation 16.50 11.68 70 31391 57672 56202934
Granuloma skin 16.43 11.68 20 31441 7031 56253575
Hypercapnia 16.22 11.68 17 31444 5079 56255527
Dizziness 15.98 11.68 297 31164 375843 55884763
Confusional state 15.86 11.68 182 31279 207973 56052633
Thrombocytopenia 15.58 11.68 33 31428 136191 56124415
Vaccination site erythema 15.51 11.68 4 31457 51 56260555
Breath sounds abnormal 15.49 11.68 22 31439 8985 56251621
Disease progression 15.18 11.68 22 31439 105151 56155455
Compulsive sexual behaviour 14.90 11.68 4 31457 60 56260546
Pyrexia 14.86 11.68 156 31305 418617 55841989
Autonomic nervous system imbalance 14.82 11.68 12 31449 2581 56258025
Feeling abnormal 14.64 11.68 126 31335 133476 56127130
Product use issue 14.64 11.68 54 31407 185987 56074619
Drug abuse 14.51 11.68 10 31451 67600 56193006
Speech disorder 14.45 11.68 50 31411 37443 56223163
Nasopharyngitis 14.38 11.68 69 31392 220890 56039716
Infusion related reaction 14.33 11.68 64 31397 208867 56051739
Stoma site candida 14.28 11.68 3 31458 14 56260592
Stoma site haemorrhage 14.02 11.68 8 31453 970 56259636
Sputum discoloured 13.88 11.68 27 31434 14265 56246341
Blood parathyroid hormone decreased 13.75 11.68 20 31441 8344 56252262
Vitamin B6 deficiency 13.69 11.68 4 31457 83 56260523
Bulimia nervosa 13.63 11.68 6 31455 418 56260188
Middle insomnia 13.58 11.68 23 31438 10927 56249679
Irritable bowel syndrome 13.56 11.68 11 31450 68447 56192159
Balance disorder 13.52 11.68 81 31380 76439 56184167
Arthropathy 13.35 11.68 62 31399 200213 56060393
Initial insomnia 13.29 11.68 16 31445 5563 56255043
Endometrial cancer 13.19 11.68 12 31449 3018 56257588
Patient elopement 13.01 11.68 3 31458 23 56260583
Condition aggravated 12.84 11.68 267 31194 344631 55915975
Muscle atrophy 12.83 11.68 17 31444 6504 56254102
Mucosal inflammation 12.78 11.68 4 31457 42806 56217800
Infection 12.74 11.68 63 31398 200143 56060463
Kleptomania 12.68 11.68 3 31458 26 56260580
Choking 12.65 11.68 20 31441 8977 56251629
Panniculitis 12.64 11.68 21 31440 9821 56250785
Anisomastia 12.48 11.68 3 31458 28 56260578
Vaccination site pain 12.29 11.68 4 31457 120 56260486
Stoma site extravasation 12.13 11.68 5 31456 296 56260310
Muscle rupture 12.01 11.68 10 31451 2236 56258370
Reduced facial expression 11.75 11.68 9 31452 1787 56258819
Skull fracture 11.68 11.68 7 31454 929 56259677

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Impulse-control disorder 762.87 14 174 19835 1102 31676233
Gambling disorder 611.51 14 152 19857 1450 31675885
Hypersexuality 589.02 14 144 19865 1274 31676061
Hallucination 450.23 14 309 19700 46101 31631234
Dyskinesia 341.43 14 194 19815 20716 31656619
On and off phenomenon 299.17 14 92 19917 2018 31675317
Restless legs syndrome 288.49 14 126 19883 7630 31669705
Dopamine dysregulation syndrome 232.86 14 52 19957 294 31677041
Hallucination, visual 196.34 14 123 19886 15671 31661664
Gambling 196.07 14 41 19968 160 31677175
Compulsive shopping 178.11 14 43 19966 358 31676977
Freezing phenomenon 123.21 14 42 19967 1288 31676047
Stereotypy 118.59 14 35 19974 663 31676672
Jealous delusion 110.15 14 27 19982 241 31677094
Obsessive-compulsive disorder 108.95 14 56 19953 4881 31672454
Needle fatigue 107.47 14 33 19976 719 31676616
Delusion 104.65 14 75 19934 11922 31665413
Gait spastic 101.57 14 33 19976 869 31676466
Relapsing-remitting multiple sclerosis 100.30 14 33 19976 905 31676430
Paraphilia 99.20 14 20 19989 62 31677273
Gait disturbance 91.05 14 170 19839 77325 31600010
Muscle rigidity 88.92 14 63 19946 9834 31667501
Nocturia 88.13 14 61 19948 9174 31668161
Libido increased 87.25 14 28 19981 708 31676627
Sudden onset of sleep 86.54 14 24 19985 360 31676975
Stoma site erythema 85.50 14 27 19982 647 31676688
Fall 84.88 14 284 19725 185805 31491530
Hypertonic bladder 80.60 14 33 19976 1697 31675638
Monoparesis 80.43 14 35 19974 2096 31675239
Parkinsonism hyperpyrexia syndrome 80.37 14 17 19992 71 31677264
Bradykinesia 77.11 14 40 19969 3552 31673783
Binge eating 74.56 14 17 19992 107 31677228
Micturition urgency 74.42 14 46 19963 5714 31671621
Memory impairment 73.90 14 105 19904 38025 31639310
Insomnia 72.92 14 175 19834 94661 31582674
Abnormal behaviour 72.22 14 82 19927 23746 31653589
Psychomotor hyperactivity 67.75 14 51 19958 8736 31668599
Movement disorder 65.74 14 55 19954 10964 31666371
Stoma site discharge 61.33 14 23 19986 934 31676401
Central nervous system lesion 60.80 14 41 19968 5907 31671428
Muscle spasticity 60.39 14 40 19969 5595 31671740
Balance disorder 59.57 14 94 19915 37328 31640007
Hyperkinesia 58.36 14 26 19983 1647 31675688
Dysarthria 54.56 14 83 19926 31934 31645401
Agitation 54.04 14 111 19898 54058 31623277
Impulsive behaviour 53.77 14 26 19983 1987 31675348
Toxicity to various agents 53.26 14 24 19985 181463 31495872
Confusional state 51.63 14 193 19816 133141 31544194
Encephalitis toxic 51.38 14 15 19994 273 31677062
Aggression 49.06 14 86 19923 37205 31640130
Compulsive hoarding 48.50 14 9 20000 15 31677320
Tremor 48.28 14 131 19878 76289 31601046
Parkinson's disease 47.84 14 22 19987 1501 31675834
Neuroleptic malignant syndrome 47.66 14 56 19953 16813 31660522
Ataxia 47.24 14 49 19960 12814 31664521
Psychotic disorder 47.07 14 64 19945 22229 31655106
Anxiety 46.86 14 145 19864 90888 31586447
Delirium 46.26 14 89 19920 41332 31636003
Stoma site pain 44.84 14 16 19993 563 31676772
Febrile neutropenia 44.63 14 11 19998 121838 31555497
Voyeurism 44.58 14 7 20002 0 31677335
Multiple sclerosis relapse 44.44 14 46 19963 12001 31665334
Neutropenia 43.67 14 17 19992 140347 31536988
Mania 43.11 14 40 19969 9137 31668198
Somnolence 42.76 14 149 19860 99296 31578039
Device dislocation 42.04 14 31 19978 5145 31672190
Sleep attacks 41.70 14 11 19998 135 31677200
Dependence 41.39 14 18 19991 1076 31676259
Diarrhoea 41.29 14 102 19907 352307 31325028
Dystonia 41.29 14 41 19968 10184 31667151
Compulsive sexual behaviour 40.33 14 12 19997 234 31677101
Pyrexia 39.58 14 83 19926 303757 31373578
Economic problem 38.80 14 18 19991 1253 31676082
Hyperphagia 38.18 14 18 19991 1300 31676035
Acute kidney injury 37.61 14 75 19934 279639 31397696
Hypomania 37.13 14 21 19988 2214 31675121
Excessive masturbation 36.35 14 9 20000 84 31677251
Posture abnormal 35.93 14 20 19989 2044 31675291
Pollakiuria 35.70 14 50 19959 17852 31659483
Dizziness 34.93 14 230 19779 198917 31478418
Restlessness 33.51 14 56 19953 23305 31654030
Suspiciousness 33.28 14 11 19998 306 31677029
Dementia 33.21 14 40 19969 12320 31665015
Delusional disorder, jealous type 31.84 14 5 20004 0 31677335
Therapeutic product effect variable 31.63 14 18 19991 1920 31675415
Paranoia 31.42 14 36 19973 10519 31666816
Akinesia 31.03 14 18 19991 1990 31675345
Personality change 30.82 14 25 19984 4770 31672565
Somnambulism 29.96 14 20 19989 2832 31674503
Depression 29.89 14 125 19884 90690 31586645
Pancytopenia 29.86 14 9 20000 87307 31590028
Disturbance in attention 29.81 14 52 19957 22398 31654937
Bipolar I disorder 29.52 14 13 19996 801 31676534
Sexually inappropriate behaviour 29.30 14 11 19998 448 31676887
Reduced facial expression 29.07 14 13 19996 831 31676504
Platelet count decreased 28.79 14 17 19992 110418 31566917
Road traffic accident 28.65 14 43 19966 16338 31660997
Cognitive disorder 28.36 14 54 19955 24869 31652466
Hypervigilance 27.91 14 8 20001 136 31677199
Contraindicated product prescribed 27.88 14 10 19999 357 31676978
Dropped head syndrome 27.70 14 8 20001 140 31677195
Acute psychosis 27.62 14 16 19993 1765 31675570
Sleep disorder 27.45 14 55 19954 26293 31651042
Erectile dysfunction 27.44 14 46 19963 19189 31658146
Obsessive-compulsive personality disorder 27.43 14 8 20001 145 31677190
Embedded device 27.10 14 9 20000 254 31677081
Motor dysfunction 26.67 14 26 19983 6313 31671022
Hallucination, tactile 26.43 14 9 20000 275 31677060
Anticholinergic syndrome 25.92 14 13 19996 1075 31676260
Compulsions 25.40 14 8 20001 190 31677145
Condition aggravated 24.93 14 183 19826 163826 31513509
Spontaneous penile erection 24.82 14 8 20001 205 31677130
Troponin increased 24.66 14 31 19978 9971 31667364
Parkinsonism 24.35 14 27 19982 7609 31669726
Human ehrlichiosis 24.29 14 8 20001 220 31677115
Malignant neoplasm progression 23.84 14 10 19999 78988 31598347
Stoma site haemorrhage 23.77 14 11 19998 761 31676574
Dysstasia 23.59 14 32 19977 11086 31666249
Drug withdrawal syndrome 23.05 14 42 19967 18708 31658627
Medical device site dryness 22.74 14 5 20004 26 31677309
Device effect decreased 22.70 14 4 20005 4 31677331
Intentional medical device removal by patient 22.68 14 8 20001 272 31677063
Depressive symptom 22.63 14 15 19994 2099 31675236
Device occlusion 22.53 14 23 19986 5902 31671433
Stoma site hypergranulation 22.48 14 7 20002 160 31677175
Bradycardia 22.46 14 95 19914 69232 31608103
Food interaction 22.09 14 11 19998 896 31676439
Sleep-related eating disorder 22.06 14 8 20001 295 31677040
Sleep apnoea syndrome 21.99 14 41 19968 18584 31658751
Stoma site inflammation 21.99 14 9 20000 462 31676873
Sepsis 21.89 14 39 19970 151890 31525445
Verbal abuse 21.88 14 7 20002 175 31677160
Rapid eye movements sleep abnormal 21.77 14 7 20002 178 31677157
Inappropriate antidiuretic hormone secretion 21.51 14 31 19978 11356 31665979
Cardiac dysfunction 21.03 14 14 19995 1973 31675362
Withdrawal syndrome 20.83 14 31 19978 11686 31665649
VACTERL syndrome 20.46 14 5 20004 44 31677291
Abnormal dreams 19.09 14 23 19986 7085 31670250
Cardiac arrest 18.93 14 17 19992 89045 31588290
Device issue 18.88 14 25 19984 8459 31668876
Marital problem 18.76 14 5 20004 64 31677271
Tension 18.57 14 13 19996 1988 31675347
Off label use 18.46 14 136 19873 347138 31330197
White blood cell count decreased 18.19 14 17 19992 87381 31589954
Stoma site infection 18.12 14 9 20000 729 31676606
Hyperkalaemia 18.08 14 9 20000 64342 31612993
Sexual activity increased 18.00 14 4 20005 22 31677313
Rash 17.99 14 66 19943 201420 31475915
Gait inability 17.64 14 38 19971 19106 31658229
Nightmare 17.27 14 29 19980 12108 31665227
Torticollis 17.27 14 10 19999 1102 31676233
Disease progression 17.23 14 19 19990 90445 31586890
Mobility decreased 17.23 14 47 19962 27422 31649913
Visual impairment 17.17 14 51 19958 31228 31646107
Anaemia 17.12 14 73 19936 213449 31463886
Eosinophilic fasciitis 17.08 14 5 20004 92 31677243
Sopor 16.97 14 28 19981 11524 31665811
Device alarm issue 16.94 14 8 20001 580 31676755
Suicidal ideation 16.89 14 56 19953 36350 31640985
Lung hyperinflation 16.88 14 9 20000 845 31676490
Interstitial lung disease 16.64 14 9 20000 61394 31615941
Device kink 16.53 14 7 20002 392 31676943
Hyperthyroidism 16.44 14 25 19984 9606 31667729
Device loosening 16.24 14 5 20004 110 31677225
Therapeutic response unexpected 16.22 14 24 19985 9000 31668335
Neutrophil count decreased 15.46 14 5 20004 46389 31630946
Mental impairment 15.23 14 24 19985 9508 31667827
Excessive exercise 15.21 14 3 20006 8 31677327
Paedophilia 15.21 14 3 20006 8 31677327
Rapid eye movement sleep behaviour disorder 15.06 14 5 20004 141 31677194
Hemivertebra 14.99 14 5 20004 143 31677192
Pleurothotonus 14.88 14 9 20000 1074 31676261
IVth nerve paresis 14.29 14 3 20006 12 31677323
Drug hypersensitivity 14.10 14 15 19994 72584 31604751

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Impulse-control disorder 754.95 11.38 178 39927 1501 70886838
Gambling disorder 658.80 11.38 164 39941 1774 70886565
Dyskinesia 559.56 11.38 326 39779 40748 70847591
Hallucination 448.34 11.38 360 39745 75900 70812439
Restless legs syndrome 413.67 11.38 204 39901 18224 70870115
On and off phenomenon 410.41 11.38 122 39983 2664 70885675
Hypersexuality 407.24 11.38 107 39998 1456 70886883
Hallucination, visual 297.60 11.38 193 39912 29144 70859195
Compulsive shopping 279.44 11.38 69 40036 719 70887620
Dopamine dysregulation syndrome 241.61 11.38 56 40049 434 70887905
Parkinsonism hyperpyrexia syndrome 212.22 11.38 44 40061 187 70888152
Gambling 184.46 11.38 41 40064 257 70888082
Freezing phenomenon 154.51 11.38 51 40054 1583 70886756
Dystonia 148.57 11.38 108 39997 19598 70868741
Stereotypy 143.98 11.38 42 40063 856 70887483
Jealous delusion 142.57 11.38 33 40072 254 70888085
Bradykinesia 127.74 11.38 69 40036 7433 70880906
Fall 121.03 11.38 534 39571 443562 70444777
Muscle rigidity 117.91 11.38 92 40013 18558 70869781
Stoma site discharge 115.76 11.38 42 40063 1737 70886602
Binge eating 115.72 11.38 31 40074 456 70887883
Delusion 115.70 11.38 92 40013 19073 70869266
Stoma site erythema 110.24 11.38 38 40067 1350 70886989
Obsessive-compulsive disorder 107.39 11.38 55 40050 5315 70883024
Tremor 106.81 11.38 257 39848 155367 70732972
Needle fatigue 101.96 11.38 31 40074 732 70887607
Hyperkinesia 99.93 11.38 42 40063 2581 70885758
Neuroleptic malignant syndrome 97.03 11.38 95 40010 25912 70862427
Psychotic disorder 95.23 11.38 112 39993 37589 70850750
Gait spastic 92.31 11.38 31 40074 1016 70887323
Compulsive hoarding 91.45 11.38 18 40087 55 70888284
Stoma site pain 91.23 11.38 32 40073 1198 70887141
Sudden onset of sleep 90.35 11.38 27 40078 600 70887739
Gait disturbance 85.23 11.38 264 39841 184842 70703497
Relapsing-remitting multiple sclerosis 84.09 11.38 31 40074 1342 70886997
Pleurothotonus 83.88 11.38 36 40069 2330 70886009
Abnormal behaviour 79.30 11.38 98 40007 34611 70853728
Insomnia 75.93 11.38 283 39822 217523 70670816
Acute psychosis 72.25 11.38 38 40067 3878 70884461
Febrile neutropenia 70.03 11.38 15 40090 204303 70684036
Akinesia 68.26 11.38 34 40071 3097 70885242
Nocturia 68.18 11.38 56 40049 12148 70876191
Therapeutic response shortened 67.76 11.38 57 40048 12781 70875558
Torticollis 66.62 11.38 30 40075 2179 70886160
Delirium 65.49 11.38 136 39969 74478 70813861
Monoparesis 64.41 11.38 33 40072 3191 70885148
Movement disorder 63.12 11.38 73 40032 24056 70864283
Paraphilia 62.94 11.38 13 40092 54 70888285
Camptocormia 61.96 11.38 19 40086 462 70887877
Orthostatic hypotension 61.08 11.38 107 39998 51636 70836703
Sleep attacks 59.67 11.38 15 40090 169 70888170
Hypertonic bladder 59.44 11.38 33 40072 3750 70884589
Neutropenia 59.30 11.38 36 40069 257120 70631219
Anxiety 56.10 11.38 260 39845 220070 70668269
Toxicity to various agents 55.84 11.38 81 40024 382091 70506248
Psychomotor hyperactivity 55.01 11.38 55 40050 15378 70872961
Impulsive behaviour 54.47 11.38 28 40077 2726 70885613
Parkinson's disease 52.94 11.38 24 40081 1771 70886568
Parkinsonism 51.67 11.38 53 40052 15272 70873067
Micturition urgency 51.16 11.38 46 40059 11268 70877071
Therapeutic product effect variable 50.86 11.38 23 40082 1687 70886652
Dropped head syndrome 50.37 11.38 14 40091 238 70888101
Drug withdrawal syndrome 49.93 11.38 76 40029 32639 70855700
Encephalitis toxic 48.28 11.38 14 40091 279 70888060
Posture abnormal 47.47 11.38 28 40077 3568 70884771
Memory impairment 47.19 11.38 137 39968 92504 70795835
Somnolence 46.71 11.38 243 39862 215363 70672976
Suspiciousness 45.54 11.38 16 40089 602 70887737
Cognitive disorder 45.39 11.38 104 40001 60852 70827487
Central nervous system lesion 43.68 11.38 44 40061 12409 70875930
Libido increased 42.84 11.38 21 40084 1848 70886491
Balance disorder 42.78 11.38 130 39975 89998 70798341
Restlessness 42.00 11.38 81 40024 42047 70846292
Pancytopenia 41.05 11.38 17 40088 151090 70737249
Agitation 40.92 11.38 131 39974 93244 70795095
Multiple sclerosis relapse 40.81 11.38 81 40024 42936 70845403
Aggression 39.83 11.38 86 40019 48360 70839979
Pyrexia 39.38 11.38 193 39912 606759 70281580
Voyeurism 38.87 11.38 6 40099 0 70888339
Rash 38.78 11.38 153 39952 510409 70377930
Diarrhoea 38.67 11.38 272 39833 783069 70105270
Malignant neoplasm progression 37.71 11.38 11 40094 121728 70766611
Economic problem 36.76 11.38 20 40085 2184 70886155
Stoma site infection 36.74 11.38 17 40088 1315 70887024
Abnormal dreams 36.35 11.38 37 40068 10566 70877773
Confusional state 36.27 11.38 280 39825 284118 70604221
Rheumatoid arthritis 35.96 11.38 69 40036 291736 70596603
Hyperphagia 35.49 11.38 20 40085 2339 70886000
Drug dispensed to wrong patient 35.21 11.38 13 40092 565 70887774
Dizziness 34.74 11.38 408 39697 463733 70424606
Withdrawal syndrome 34.04 11.38 55 40050 24849 70863490
Pericarditis 33.99 11.38 4 40101 84701 70803638
Mania 33.73 11.38 45 40060 17129 70871210
Depressive symptom 33.70 11.38 26 40079 5155 70883184
Excessive masturbation 33.45 11.38 8 40097 72 70888267
Compulsions 33.09 11.38 11 40094 349 70887990
Depressed mood 32.88 11.38 75 40030 43745 70844594
Reduced facial expression 32.86 11.38 19 40086 2333 70886006
Dementia 32.78 11.38 51 40054 22314 70866025
Hand deformity 32.52 11.38 5 40100 86477 70801862
Acute kidney injury 32.47 11.38 148 39957 474476 70413863
Delusional disorder, jealous type 32.39 11.38 5 40100 0 70888339
Erectile dysfunction 32.11 11.38 39 40066 13523 70874816
Nightmare 31.75 11.38 50 40055 22106 70866233
Medication error 31.75 11.38 87 40018 56825 70831514
Total lung capacity decreased 30.46 11.38 17 40088 1952 70886387
Troponin increased 30.31 11.38 42 40063 16572 70871767
Multiple drug therapy 29.91 11.38 20 40085 3172 70885167
Blood pressure inadequately controlled 29.86 11.38 25 40080 5567 70882772
Dysarthria 29.67 11.38 90 40015 62223 70826116
Stomatitis 29.58 11.38 18 40087 128493 70759846
Condition aggravated 29.40 11.38 370 39735 427265 70461074
Oedema peripheral 29.30 11.38 225 39880 227866 70660473
Ataxia 28.68 11.38 49 40056 23168 70865171
Glossodynia 28.32 11.38 7 40098 86480 70801859
Maternal exposure during pregnancy 28.21 11.38 15 40090 115330 70773009
Bronchopulmonary aspergillosis allergic 27.76 11.38 16 40089 1953 70886386
Inappropriate antidiuretic hormone secretion 27.29 11.38 48 40057 23228 70865111
Malignant polyp 27.29 11.38 8 40097 166 70888173
Pollakiuria 27.04 11.38 59 40046 33402 70854937
Snoring 26.34 11.38 22 40083 4882 70883457
Prescribed underdose 26.24 11.38 45 40060 21340 70866999
Sexually inappropriate behaviour 25.66 11.38 10 40095 505 70887834
Contraindicated product administered 25.62 11.38 23 40082 134589 70753750
Dependence 25.46 11.38 16 40089 2284 70886055
Discomfort 25.36 11.38 14 40091 105422 70782917
Marital problem 25.29 11.38 8 40097 216 70888123
Personality change 25.17 11.38 28 40077 8842 70879497
Obsessive-compulsive personality disorder 24.97 11.38 7 40098 123 70888216
Platelet count decreased 24.80 11.38 39 40066 178183 70710156
Sleep apnoea syndrome 24.55 11.38 56 40049 32657 70855682
Product residue present 24.33 11.38 18 40087 3352 70884987
Compulsive sexual behaviour 24.18 11.38 8 40097 250 70888089
Kleptomania 23.62 11.38 5 40100 24 70888315
Muscle spasticity 23.60 11.38 41 40064 19648 70868691
Dysstasia 23.38 11.38 47 40058 25132 70863207
Device dislocation 23.32 11.38 44 40061 22463 70865876
Depression 23.21 11.38 192 39913 198782 70689557
Diabetes mellitus inadequate control 23.13 11.38 44 40061 22601 70865738
Bipolar I disorder 22.91 11.38 14 40091 1903 70886436
Pituitary haemorrhage 22.87 11.38 8 40097 297 70888042
Disturbance in attention 22.37 11.38 64 40041 42830 70845509
Cardiac arrest 22.21 11.38 35 40070 159799 70728540
Hallucination, tactile 21.94 11.38 9 40096 520 70887819
Therapeutic response unexpected 21.89 11.38 38 40067 18193 70870146
Vaccination site bruising 21.87 11.38 4 40101 7 70888332
Chorea 21.87 11.38 14 40091 2064 70886275
Pulmonary fibrosis 21.73 11.38 55 40050 34255 70854084
Vaccination site pruritus 21.52 11.38 4 40101 8 70888331
Vaccination site oedema 21.52 11.38 4 40101 8 70888331
Off label use 21.38 11.38 294 39811 742766 70145573
Orthostatic intolerance 21.36 11.38 13 40092 1754 70886585
Mucosal inflammation 21.25 11.38 6 40099 67844 70820495
Product prescribing error 21.18 11.38 59 40046 38893 70849446
Device occlusion 21.17 11.38 28 40077 10567 70877772
Hyperventilation 20.94 11.38 23 40082 7163 70881176
Spontaneous penile erection 20.67 11.38 6 40099 120 70888219
Lung opacity 20.66 11.38 17 40088 3696 70884643
Stoma site inflammation 20.63 11.38 9 40096 606 70887733
Suicidal ideation 20.61 11.38 86 40019 69510 70818829
Stoma site hypergranulation 20.58 11.38 8 40097 401 70887938
Blister 20.58 11.38 16 40089 100510 70787829
Human ehrlichiosis 20.47 11.38 8 40097 407 70887932
Autonomic nervous system imbalance 20.33 11.38 18 40087 4321 70884018
Alopecia 20.27 11.38 52 40053 198438 70689901
Synovitis 20.23 11.38 26 40079 129202 70759137
Rapid eye movements sleep abnormal 20.22 11.38 7 40098 252 70888087
Drug intolerance 20.19 11.38 63 40042 225624 70662715
Verbal abuse 20.09 11.38 7 40098 257 70888082
Food interaction 19.98 11.38 12 40093 1581 70886758
Hypervigilance 19.52 11.38 8 40097 461 70887878
Paedophilia 19.44 11.38 3 40102 0 70888339
Paranoia 19.43 11.38 35 40070 17253 70871086
Disease progression 19.32 11.38 37 40068 156635 70731704
Vestibular migraine 19.30 11.38 6 40099 153 70888186
Thrombocytopenia 19.18 11.38 70 40035 239040 70649299
Duodenal ulcer perforation 19.11 11.38 3 40102 51109 70837230
Irritable bowel syndrome 18.98 11.38 3 40102 50847 70837492
Device kink 18.91 11.38 12 40093 1743 70886596
Urticaria 18.83 11.38 40 40065 163009 70725330
Hypomania 18.68 11.38 20 40085 6052 70882287
Hypersensitivity 18.61 11.38 67 40038 229745 70658594
Intentional medical device removal by patient 18.06 11.38 7 40098 348 70887991
Bone marrow failure 18.05 11.38 3 40102 49007 70839332
Product substitution issue 17.72 11.38 35 40070 18478 70869861
Female orgasmic disorder 17.49 11.38 4 40101 29 70888310
White blood cell count decreased 17.05 11.38 45 40060 170096 70718243
Blood calcium increased 16.80 11.38 23 40082 8970 70879369
Device issue 16.79 11.38 40 40065 23985 70864354
Stoma site haemorrhage 16.72 11.38 11 40094 1698 70886641
Drug reaction with eosinophilia and systemic symptoms 16.62 11.38 6 40099 58007 70830332
Hepatocellular injury 16.58 11.38 3 40102 46088 70842251
Nasopharyngitis 16.56 11.38 67 40038 222139 70666200
Fibroma 16.37 11.38 8 40097 699 70887640
Obsessive thoughts 16.12 11.38 9 40096 1034 70887305
Joint swelling 16.08 11.38 81 40024 253130 70635209
Conjunctival discolouration 16.06 11.38 5 40100 128 70888211
Serum serotonin increased 15.97 11.38 6 40099 274 70888065
Contraindicated product prescribed 15.88 11.38 10 40095 1433 70886906
Abdominal discomfort 15.82 11.38 65 40040 214593 70673746
Delusion of replacement 15.31 11.38 5 40100 150 70888189
Exercise tolerance decreased 15.27 11.38 21 40084 8227 70880112
Anticholinergic syndrome 15.25 11.38 13 40092 2967 70885372
Stoma site extravasation 15.12 11.38 6 40099 318 70888021
Vaccination site erythema 15.11 11.38 4 40101 56 70888283
Stoma site candida 15.04 11.38 3 40102 10 70888329
Parkinsonian gait 14.86 11.38 8 40097 856 70887483
Ascites 14.80 11.38 10 40095 67537 70820802
Orgasm abnormal 14.63 11.38 5 40100 173 70888166
Speech disorder 14.59 11.38 62 40043 50518 70837821
Swelling 14.59 11.38 56 40049 188483 70699856
Sleep disorder 14.58 11.38 78 40027 69794 70818545
Choking 14.54 11.38 24 40081 11036 70877303
Interstitial lung disease 14.47 11.38 23 40082 104662 70783677
Device connection issue 14.46 11.38 8 40097 903 70887436
Neutrophil count decreased 13.93 11.38 16 40089 83540 70804799
Somnambulism 13.90 11.38 16 40089 5244 70883095
Feeling abnormal 13.83 11.38 132 39973 142187 70746152
Drug tolerance decreased 13.82 11.38 22 40083 9811 70878528
Hiccups 13.77 11.38 21 40084 9031 70879308
Coronary artery dissection 13.73 11.38 8 40097 996 70887343
Amnesia 13.57 11.38 62 40043 52093 70836246
Ill-defined disorder 13.55 11.38 7 40098 54734 70833605
Euphoric mood 13.45 11.38 18 40087 6871 70881468
Sleep-related eating disorder 13.42 11.38 7 40098 702 70887637
Plasma cell myeloma 13.35 11.38 13 40092 73188 70815151
Cardiac dysfunction 13.34 11.38 13 40092 3524 70884815
Treatment failure 13.05 11.38 40 40065 144102 70744237
Micturition disorder 12.92 11.38 13 40092 3662 70884677
Motor dysfunction 12.86 11.38 25 40080 13045 70875294
Anisomastia 12.86 11.38 3 40102 24 70888315
Hypersomnia 12.85 11.38 33 40072 20731 70867608
Muscle injury 12.83 11.38 3 40102 38491 70849848
Bradycardia 12.82 11.38 117 39988 124498 70763841
Stoma site irritation 12.80 11.38 5 40100 254 70888085
Heat stroke 12.77 11.38 9 40096 1554 70886785
Middle insomnia 12.77 11.38 26 40079 14027 70874312
Sputum discoloured 12.76 11.38 31 40074 18820 70869519
Sexual activity increased 12.75 11.38 3 40102 25 70888314
Drug resistance 12.68 11.38 3 40102 38187 70850152
Eosinophilic fasciitis 12.54 11.38 5 40100 268 70888071
Excessive exercise 12.54 11.38 3 40102 27 70888312
Inhibitory drug interaction 12.53 11.38 13 40092 3794 70884545
Vaccination site pain 12.34 11.38 4 40101 117 70888222
Meningorrhagia 12.22 11.38 5 40100 287 70888052
Deep vein thrombosis 12.19 11.38 28 40077 111014 70777325
Liver injury 12.18 11.38 4 40101 41031 70847308
Bladder sphincter atony 12.03 11.38 4 40101 127 70888212
Lung hyperinflation 11.99 11.38 9 40096 1712 70886627
Apathy 11.99 11.38 23 40082 11885 70876454
Sepsis 11.95 11.38 85 40020 244460 70643879
Granuloma skin 11.94 11.38 18 40087 7664 70880675
Irritability 11.92 11.38 48 40057 38177 70850162
Aspiration 11.89 11.38 29 40076 17646 70870693
Keloid scar 11.86 11.38 4 40101 133 70888206
Blood creatine phosphokinase increased 11.85 11.38 67 40038 61196 70827143
Agranulocytosis 11.83 11.38 4 40101 40294 70848045
Underdose 11.77 11.38 40 40065 29343 70858996
Metabolic acidosis 11.59 11.38 15 40090 74331 70814008
Exposure during pregnancy 11.44 11.38 20 40085 87697 70800642
Infection 11.44 11.38 71 40034 210714 70677625

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N04BC05 NERVOUS SYSTEM
ANTI-PARKINSON DRUGS
DOPAMINERGIC AGENTS
Dopamine agonists
FDA MoA N0000000117 Dopamine Agonists
MeSH PA D018726 Anti-Dyskinesia Agents
MeSH PA D000975 Antioxidants
MeSH PA D000978 Antiparkinson Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D015259 Dopamine Agents
MeSH PA D018491 Dopamine Agonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D020011 Protective Agents
CHEBI has role CHEBI:48407 antiparkinson agent
CHEBI has role CHEBI:48578 free radical scavengers
CHEBI has role CHEBI:51065 Dopamine receptor agonist
CHEBI has role CHEBI:66956 antidyskinetic agent
FDA EPC N0000175768 Nonergot Dopamine Agonist

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Restless legs indication 32914008 DOID:0050425
Parkinson's disease indication 49049000 DOID:14330
Fibromyalgia off-label use 203082005 DOID:631
Hallucinations contraindication 7011001
Dyskinesia contraindication 9748009
Orthostatic hypotension contraindication 28651003
Narcolepsy contraindication 60380001 DOID:8986
Psychotic disorder contraindication 69322001
Sleep apnea contraindication 73430006 DOID:0050847
Kidney disease contraindication 90708001 DOID:557
Drowsy contraindication 271782001
Malignant melanoma contraindication 372244006
Breastfeeding (mother) contraindication 413712001




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.57 Basic
pKa2 5.18 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.375MG MIRAPEX ER BOEHRINGER INGELHEIM N022421 Feb. 19, 2010 RX TABLET, EXTENDED RELEASE ORAL 8679533 Sept. 8, 2029 TREATMENT OF PARKINSONS DISEASE
0.75MG MIRAPEX ER BOEHRINGER INGELHEIM N022421 Feb. 19, 2010 RX TABLET, EXTENDED RELEASE ORAL 8679533 Sept. 8, 2029 TREATMENT OF PARKINSONS DISEASE
1.5MG MIRAPEX ER BOEHRINGER INGELHEIM N022421 Feb. 19, 2010 RX TABLET, EXTENDED RELEASE ORAL 8679533 Sept. 8, 2029 TREATMENT OF PARKINSONS DISEASE
2.25MG MIRAPEX ER BOEHRINGER INGELHEIM N022421 June 17, 2011 RX TABLET, EXTENDED RELEASE ORAL 8679533 Sept. 8, 2029 TREATMENT OF PARKINSONS DISEASE
3.75MG MIRAPEX ER BOEHRINGER INGELHEIM N022421 June 17, 2011 RX TABLET, EXTENDED RELEASE ORAL 8679533 Sept. 8, 2029 TREATMENT OF PARKINSONS DISEASE
3MG MIRAPEX ER BOEHRINGER INGELHEIM N022421 Feb. 19, 2010 RX TABLET, EXTENDED RELEASE ORAL 8679533 Sept. 8, 2029 TREATMENT OF PARKINSONS DISEASE
4.5MG MIRAPEX ER BOEHRINGER INGELHEIM N022421 Feb. 19, 2010 RX TABLET, EXTENDED RELEASE ORAL 8679533 Sept. 8, 2029 TREATMENT OF PARKINSONS DISEASE

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(2) dopamine receptor GPCR AGONIST EC50 6.60 WOMBAT-PK CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 7.12 PDSP
5-hydroxytryptamine receptor 1A GPCR Ki 6.16 WOMBAT-PK
5-hydroxytryptamine receptor 2A GPCR EC50 5.93 CHEMBL
5-hydroxytryptamine receptor 7 GPCR Ki 5.93 PDSP
Alpha-2B adrenergic receptor GPCR Ki 6.20 WOMBAT-PK
D(3) dopamine receptor GPCR AGONIST EC50 8.67 WOMBAT-PK
Histamine H2 receptor GPCR Ki 5.57 PDSP
5-hydroxytryptamine receptor 1B GPCR Ki 5.46 PDSP
5-hydroxytryptamine receptor 1D GPCR Ki 5.78 PDSP
Alpha-2C adrenergic receptor GPCR Ki 7.28 PDSP
D(4) dopamine receptor GPCR AGONIST Ki 9.31 CHEMBL
Beta-2 adrenergic receptor GPCR Ki 4 CHEMBL
D(2) dopamine receptor GPCR Ki 8.51 CHEMBL
D(2) dopamine receptor GPCR Kd 8.80 CHEMBL
D(3) dopamine receptor GPCR Ki 9.35 CHEMBL

External reference:

IDSource
4024071 VUID
N0000022076 NUI
D00559 KEGG_DRUG
191217-81-9 SECONDARY_CAS_RN
4021042 VANDF
4024071 VANDF
C0074710 UMLSCUI
CHEBI:8356 CHEBI
G6L PDB_CHEM_ID
CHEMBL301265 ChEMBL_ID
DB00413 DRUGBANK_ID
CHEMBL3182733 ChEMBL_ID
CHEMBL542257 ChEMBL_ID
D000077487 MESH_DESCRIPTOR_UI
119570 PUBCHEM_CID
6227 INN_ID
953 IUPHAR_LIGAND_ID
83619PEU5T UNII
236747 RXNORM
169631 MMSL
23370 MMSL
5340 MMSL
d04145 MMSL
006721 NDDF
006722 NDDF
108471007 SNOMEDCT_US
386852009 SNOMEDCT_US
412282004 SNOMEDCT_US
725650009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Mirapex ER HUMAN PRESCRIPTION DRUG LABEL 1 0597-0109 TABLET, EXTENDED RELEASE 0.38 mg ORAL NDA 32 sections
Mirapex ER HUMAN PRESCRIPTION DRUG LABEL 1 0597-0109 TABLET, EXTENDED RELEASE 0.38 mg ORAL NDA 32 sections
Mirapex ER HUMAN PRESCRIPTION DRUG LABEL 1 0597-0113 TABLET, EXTENDED RELEASE 1.50 mg ORAL NDA 32 sections
Mirapex ER HUMAN PRESCRIPTION DRUG LABEL 1 0597-0113 TABLET, EXTENDED RELEASE 1.50 mg ORAL NDA 32 sections
Mirapex ER HUMAN PRESCRIPTION DRUG LABEL 1 0597-0115 TABLET, EXTENDED RELEASE 3 mg ORAL NDA 32 sections
Mirapex ER HUMAN PRESCRIPTION DRUG LABEL 1 0597-0115 TABLET, EXTENDED RELEASE 3 mg ORAL NDA 32 sections
Mirapex ER HUMAN PRESCRIPTION DRUG LABEL 1 0597-0116 TABLET, EXTENDED RELEASE 4.50 mg ORAL NDA 32 sections
Mirapex ER HUMAN PRESCRIPTION DRUG LABEL 1 0597-0116 TABLET, EXTENDED RELEASE 4.50 mg ORAL NDA 32 sections
Mirapex ER HUMAN PRESCRIPTION DRUG LABEL 1 0597-0285 TABLET, EXTENDED RELEASE 0.75 mg ORAL NDA 32 sections
Mirapex ER HUMAN PRESCRIPTION DRUG LABEL 1 0597-0285 TABLET, EXTENDED RELEASE 0.75 mg ORAL NDA 32 sections
Mirapex ER HUMAN PRESCRIPTION DRUG LABEL 1 0597-0286 TABLET, EXTENDED RELEASE 2.25 mg ORAL NDA 32 sections
Mirapex ER HUMAN PRESCRIPTION DRUG LABEL 1 0597-0286 TABLET, EXTENDED RELEASE 2.25 mg ORAL NDA 32 sections
Mirapex ER HUMAN PRESCRIPTION DRUG LABEL 1 0597-0287 TABLET, EXTENDED RELEASE 3.75 mg ORAL NDA 32 sections
Mirapex ER HUMAN PRESCRIPTION DRUG LABEL 1 0597-0287 TABLET, EXTENDED RELEASE 3.75 mg ORAL NDA 32 sections
Pramipexole Dihydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-7597 TABLET 1 mg ORAL ANDA 28 sections
Pramipexole Dihydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6704 TABLET 0.25 mg ORAL ANDA 20 sections
Pramipexole Dihydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6704 TABLET 0.25 mg ORAL ANDA 20 sections
Pramipexole DihydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-251 TABLET, EXTENDED RELEASE 0.38 mg ORAL ANDA 28 sections
Pramipexole DihydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-251 TABLET, EXTENDED RELEASE 0.38 mg ORAL ANDA 28 sections
Pramipexole DihydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-252 TABLET, EXTENDED RELEASE 0.75 mg ORAL ANDA 28 sections
Pramipexole DihydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-252 TABLET, EXTENDED RELEASE 0.75 mg ORAL ANDA 28 sections
Pramipexole DihydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-253 TABLET, EXTENDED RELEASE 1.50 mg ORAL ANDA 28 sections
Pramipexole DihydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-253 TABLET, EXTENDED RELEASE 1.50 mg ORAL ANDA 28 sections
Pramipexole DihydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-254 TABLET, EXTENDED RELEASE 3 mg ORAL ANDA 28 sections
Pramipexole DihydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-254 TABLET, EXTENDED RELEASE 3 mg ORAL ANDA 28 sections
Pramipexole DihydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-255 TABLET, EXTENDED RELEASE 4.50 mg ORAL ANDA 28 sections
Pramipexole DihydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-255 TABLET, EXTENDED RELEASE 4.50 mg ORAL ANDA 28 sections
Pramipexole DihydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-305 TABLET, EXTENDED RELEASE 2.25 mg ORAL ANDA 28 sections
Pramipexole DihydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-305 TABLET, EXTENDED RELEASE 2.25 mg ORAL ANDA 28 sections
Pramipexole DihydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-306 TABLET, EXTENDED RELEASE 3.75 mg ORAL ANDA 28 sections