pramipexole ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2233 104632-26-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pramipexole hydrochloride
  • pramipexole hydrochloride hydrate
  • sifrol
  • oprymea
  • pramipexole
  • (S)-Pramipexole
  • mirapexin
  • pramipexole dihydrochloride
  • pramipexole dihydrochloride monohydrate
  • pramipexole HCl
  • pramipexol dihydrobromide
A dopamine agonist that binds with high selectivity and specificity to the D2 subfamily of dopamine receptors of which it has a preferential affinity to D3 receptors, and has full intrinsic activity. Pramipexole alleviates parkinsonian motor deficits by stimulation of dopamine receptors in the striatum. Animal studies have shown that pramipexole inhibits dopamine synthesis, release, and turnover.
  • Molecular weight: 211.33
  • Formula: C10H17N3S
  • CLOGP: 1.47
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 50.94
  • ALOGS: -3.18
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2.50 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.20 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 90 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.30 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 93 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 7 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7.20 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.85 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 12.40 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 1, 1997 FDA BOEHRINGER INGELHEIM

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gambling disorder 419.43 11.47 104 28872 1090 50575058
Dyskinesia 360.85 11.47 215 28761 27646 50548502
Impulse-control disorder 315.88 11.47 74 28902 596 50575552
Compulsive shopping 279.86 11.47 68 28908 650 50575498
On and off phenomenon 252.12 11.47 72 28904 1340 50574808
Hallucination 225.82 11.47 198 28778 46459 50529689
Hallucination, visual 161.82 11.47 107 28869 16475 50559673
Gambling 154.10 11.47 34 28942 202 50575946
Parkinsonism hyperpyrexia syndrome 131 11.47 27 28949 109 50576039
Restless legs syndrome 123.14 11.47 89 28887 15808 50560340
Hypersexuality 112.73 11.47 30 28946 424 50575724
Tremor 111.77 11.47 220 28756 114683 50461465
Dystonia 111.64 11.47 75 28901 11851 50564297
Freezing phenomenon 96.87 11.47 32 28944 983 50575165
Pleurothotonus 92.87 11.47 33 28943 1268 50574880
Obsessive-compulsive disorder 92.79 11.47 43 28933 3297 50572851
Bradykinesia 91.94 11.47 45 28931 3898 50572250
Sudden onset of sleep 89.93 11.47 26 28950 506 50575642
Stoma site discharge 89.72 11.47 32 28944 1243 50574905
Stoma site erythema 88.69 11.47 29 28947 862 50575286
Muscle rigidity 85.32 11.47 59 28917 9770 50566378
Stereotypy 84.30 11.47 23 28953 359 50575789
Binge eating 74.28 11.47 21 28955 376 50575772
Stoma site pain 71.39 11.47 24 28952 779 50575369
Camptocormia 70.53 11.47 19 28957 282 50575866
Orthostatic hypotension 69.36 11.47 85 28891 29396 50546752
Systemic lupus erythematosus 67.75 11.47 3 28973 140619 50435529
Fall 65.48 11.47 370 28606 334562 50241586
Jealous delusion 63.16 11.47 12 28964 28 50576120
Hyperkinesia 54.20 11.47 23 28953 1429 50574719
Therapeutic response shortened 54.11 11.47 40 28936 7349 50568799
Compulsive hoarding 52.31 11.47 11 28965 50 50576098
Delusion 51.36 11.47 45 28931 10524 50565624
Drug dispensed to wrong patient 48.96 11.47 13 28963 182 50575966
Contraindicated product administered 47.93 11.47 13 28963 148945 50427203
Maternal exposure during pregnancy 47.69 11.47 16 28960 159762 50416386
Torticollis 47.14 11.47 22 28954 1714 50574434
Psychotic disorder 46.70 11.47 60 28916 21752 50554396
Diabetes mellitus inadequate control 46.64 11.47 47 28929 13098 50563050
Glossodynia 45.83 11.47 6 28970 115563 50460585
Synovitis 45.54 11.47 8 28968 123857 50452291
Acute psychosis 44.88 11.47 23 28953 2197 50573951
Medication error 43.67 11.47 76 28900 36028 50540120
Neuroleptic malignant syndrome 41.72 11.47 41 28935 11089 50565059
Somnolence 39.81 11.47 185 28791 154800 50421348
Abnormal dreams 39.81 11.47 37 28939 9340 50566808
Abnormal behaviour 38.86 11.47 52 28924 19606 50556542
Vestibular migraine 38.44 11.47 11 28965 206 50575942
Sleep attacks 37.82 11.47 9 28967 78 50576070
Akinesia 37.64 11.47 18 28958 1481 50574667
Joint swelling 36.92 11.47 52 28924 245234 50330914
Gait disturbance 36.30 11.47 176 28800 149829 50426319
Multiple drug therapy 36.09 11.47 19 28957 1918 50574230
Febrile neutropenia 34.42 11.47 7 28969 97660 50478488
Psychomotor hyperactivity 34.37 11.47 34 28942 9267 50566881
Pericarditis 33.96 11.47 3 28973 78686 50497462
Alopecia 33.00 11.47 56 28920 244991 50331157
Pituitary haemorrhage 32.50 11.47 8 28968 81 50576067
Hand deformity 31.74 11.47 9 28967 100190 50475958
Dopamine dysregulation syndrome 31.53 11.47 9 28967 167 50575981
Delirium 31.05 11.47 68 28908 38124 50538024
Malignant polyp 31.04 11.47 9 28967 177 50575971
Dependence 31.04 11.47 17 28959 1858 50574290
Dropped head syndrome 30.89 11.47 8 28968 101 50576047
Blood pressure inadequately controlled 30.48 11.47 23 28953 4357 50571791
Drug intolerance 29.56 11.47 50 28926 219054 50357094
Anxiety 29.34 11.47 188 28788 177418 50398730
Product prescribing error 29.18 11.47 47 28929 20914 50555234
Bronchopulmonary aspergillosis allergic 28.99 11.47 14 28962 1177 50574971
Memory impairment 28.45 11.47 105 28871 79255 50496893
Parkinsonism 28.44 11.47 30 28946 8817 50567331
Economic problem 28.25 11.47 16 28960 1866 50574282
Neutropenia 28.07 11.47 26 28950 147939 50428209
Total lung capacity decreased 27.92 11.47 14 28962 1277 50574871
Lung opacity 27.54 11.47 16 28960 1957 50574191
Treatment failure 27.54 11.47 23 28953 137614 50438534
Hypersensitivity 27.31 11.47 51 28925 215110 50361038
Stoma site infection 27.11 11.47 11 28965 610 50575538
Rash 26.97 11.47 144 28832 437327 50138821
Exercise tolerance decreased 26.22 11.47 22 28954 4852 50571296
Malignant neoplasm progression 25.92 11.47 4 28972 68120 50508028
Hyperphagia 25.66 11.47 14 28962 1518 50574630
Crime 25.41 11.47 5 28971 15 50576133
Orthostatic intolerance 25.34 11.47 12 28964 966 50575182
Fibroma 25.32 11.47 11 28965 724 50575424
Depressed mood 24.78 11.47 58 28918 33965 50542183
Amnesia 24.45 11.47 66 28910 42194 50533954
Discomfort 24.41 11.47 16 28960 108364 50467784
Hyperventilation 24.24 11.47 22 28954 5387 50570761
Posture abnormal 24.13 11.47 15 28961 2074 50574074
Deep brain stimulation 23.22 11.47 5 28971 26 50576122
Oedema peripheral 22.37 11.47 161 28815 157800 50418348
Abdominal discomfort 22.08 11.47 64 28912 231577 50344571
Vaccination site oedema 21.82 11.47 4 28972 7 50576141
Swelling 21.81 11.47 52 28924 200820 50375328
Chorea 21.77 11.47 12 28964 1328 50574820
Cognitive disorder 21.72 11.47 65 28911 44058 50532090
Compulsions 21.51 11.47 7 28969 205 50575943
Vaccination site bruising 21.47 11.47 4 28972 8 50576140
Vaccination site pruritus 21.47 11.47 4 28972 8 50576140
Withdrawal syndrome 21.23 11.47 37 28939 17553 50558595
Movement disorder 21.16 11.47 37 28939 17595 50558553
Sleep apnoea syndrome 21.13 11.47 44 28932 23824 50552324
Nightmare 20.95 11.47 35 28941 16051 50560097
Therapeutic response changed 20.91 11.47 10 28966 823 50575325
Female orgasmic disorder 20.28 11.47 5 28971 51 50576097
Insomnia 20.20 11.47 170 28806 174695 50401453
Heat stroke 20.14 11.47 9 28967 634 50575514
Infusion related reaction 19.95 11.47 42 28934 169515 50406633
Exposure during pregnancy 19.88 11.47 24 28952 120991 50455157
Snoring 19.72 11.47 16 28960 3368 50572780
Drug withdrawal syndrome 19.64 11.47 44 28932 25037 50551111
Coronary artery dissection 19.08 11.47 9 28967 718 50575430
Confusional state 19.02 11.47 176 28800 185752 50390396
Drug interaction 18.96 11.47 186 28790 199435 50376713
Diarrhoea 18.94 11.47 231 28745 588245 49987903
Serum serotonin increased 18.79 11.47 6 28970 165 50575983
Product residue present 18.58 11.47 16 28960 3656 50572492
Stoma site irritation 18.46 11.47 6 28970 175 50575973
Suspiciousness 18.43 11.47 7 28969 325 50575823
Inhibitory drug interaction 18.43 11.47 13 28963 2220 50573928
Restlessness 18.43 11.47 43 28933 25130 50551018
Therapeutic product effect variable 18.37 11.47 10 28966 1080 50575068
Orgasm abnormal 17.98 11.47 5 28971 84 50576064
Narcolepsy 17.78 11.47 10 28966 1150 50574998
Pre-existing condition improved 17.56 11.47 21 28955 7076 50569072
Product substitution issue 17.53 11.47 30 28946 14027 50562121
Parkinson's disease 17.51 11.47 10 28966 1185 50574963
Rheumatoid arthritis 17.16 11.47 59 28917 202491 50373657
Stoma site inflammation 17.05 11.47 7 28969 400 50575748
Meningorrhagia 16.89 11.47 5 28971 106 50576042
Pancytopenia 16.85 11.47 14 28962 84016 50492132
Bipolar disorder 16.73 11.47 20 28956 6737 50569411
Toxicity to various agents 16.61 11.47 64 28912 212435 50363713
Arthropathy 16.25 11.47 42 28934 157864 50418284
Blood calcium increased 16.15 11.47 21 28955 7698 50568450
Feeling abnormal 16.11 11.47 125 28851 125367 50450781
Product use issue 15.97 11.47 39 28937 149436 50426712
Stoma site hypergranulation 15.71 11.47 6 28970 283 50575865
Vaccination site erythema 15.56 11.47 4 28972 49 50576099
Autonomic nervous system imbalance 15.45 11.47 12 28964 2373 50573775
Hypercapnia 15.43 11.47 16 28960 4611 50571537
Off label use 15.33 11.47 186 28790 474240 50101908
Compulsive sexual behaviour 14.81 11.47 4 28972 60 50576088
Disease progression 14.72 11.47 20 28956 95846 50480302
Stomatitis 14.71 11.47 22 28954 101322 50474826
Aspiration 14.60 11.47 22 28954 9242 50566906
Dizziness 14.32 11.47 278 28698 346091 50230057
Stoma site candida 14.20 11.47 3 28973 14 50576134
Vitamin B6 deficiency 13.93 11.47 4 28972 76 50576072
Thrombocytopenia 13.89 11.47 33 28943 127640 50448508
Vaccination site pain 13.78 11.47 4 28972 79 50576069
Depression 13.73 11.47 150 28826 165273 50410875
Bulimia nervosa 13.72 11.47 6 28970 401 50575747
Stoma site reaction 13.67 11.47 5 28971 209 50575939
Speech disorder 13.55 11.47 48 28928 35500 50540648
Middle insomnia 13.47 11.47 22 28954 9899 50566249
Endometrial cancer 13.46 11.47 12 28964 2871 50573277
Muscle atrophy 13.35 11.47 17 28959 6104 50570044
Drug abuse 13.25 11.47 9 28967 59837 50516311
Choking 13.14 11.47 20 28956 8478 50567670
Balance disorder 13.07 11.47 77 28899 70513 50505635
Hepatic enzyme increased 13.04 11.47 38 28938 137342 50438806
Anisomastia 12.82 11.47 3 28973 24 50576124
Kleptomania 12.61 11.47 3 28973 26 50576122
Reduced facial expression 12.51 11.47 9 28967 1585 50574563
Tardive dyskinesia 12.51 11.47 18 28958 7261 50568887
Ill-defined disorder 12.39 11.47 8 28968 54646 50521502
Muscle injury 12.38 11.47 3 28973 37108 50539040
Mucosal inflammation 12.00 11.47 4 28972 40138 50536010
Suicidal ideation 11.97 11.47 63 28913 55322 50520826
Blister 11.96 11.47 19 28957 85399 50490749
Medical device site dryness 11.88 11.47 3 28973 34 50576114
Accidental overdose 11.80 11.47 31 28945 19502 50556646
Rheumatoid factor positive 11.72 11.47 7 28969 49852 50526296
Chronic obstructive pulmonary disease 11.70 11.47 61 28915 53374 50522774
Product administration error 11.63 11.47 31 28945 19668 50556480
Skull fracture 11.59 11.47 7 28969 919 50575229
Device kink 11.50 11.47 9 28967 1798 50574350

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Impulse-control disorder 724.53 14.22 166 18758 1059 29554544
Gambling disorder 607.04 14.22 151 18773 1424 29554179
Hypersexuality 573.08 14.22 140 18784 1216 29554387
Hallucination 416.77 14.22 292 18632 44420 29511183
Dyskinesia 322.21 14.22 185 18739 19876 29535727
On and off phenomenon 263.54 14.22 82 18842 1846 29553757
Dopamine dysregulation syndrome 223.79 14.22 50 18874 279 29555324
Gambling 196.34 14.22 41 18883 156 29555447
Hallucination, visual 187.88 14.22 118 18806 14897 29540706
Compulsive shopping 178.28 14.22 43 18881 351 29555252
Stereotypy 120.11 14.22 35 18889 624 29554979
Jealous delusion 116.33 14.22 27 18897 183 29555420
Obsessive-compulsive disorder 112.26 14.22 56 18868 4520 29551083
Freezing phenomenon 109.17 14.22 38 18886 1225 29554378
Delusion 105.95 14.22 74 18850 11142 29544461
Paraphilia 98.93 14.22 20 18904 62 29555541
Restless legs syndrome 92.66 14.22 57 18867 6927 29548676
Needle fatigue 88.24 14.22 27 18897 573 29555030
Gait disturbance 87.23 14.22 163 18761 73186 29482417
Gait spastic 84.52 14.22 27 18897 663 29554940
Muscle rigidity 84.04 14.22 60 18864 9351 29546252
Libido increased 83.36 14.22 27 18897 694 29554909
Relapsing-remitting multiple sclerosis 82.95 14.22 27 18897 705 29554898
Sudden onset of sleep 81.90 14.22 23 18901 357 29555246
Fall 80.96 14.22 273 18651 176905 29378698
Parkinsonism hyperpyrexia syndrome 80.14 14.22 17 18907 71 29555532
Bradykinesia 75.27 14.22 39 18885 3408 29552195
Abnormal behaviour 73.32 14.22 82 18842 23045 29532558
Stoma site erythema 70.29 14.22 23 18901 611 29554992
Psychomotor hyperactivity 70.21 14.22 51 18873 8162 29547441
Nocturia 69.39 14.22 51 18873 8311 29547292
Insomnia 69.15 14.22 166 18758 88595 29467008
Hypertonic bladder 64.85 14.22 27 18897 1429 29554174
Monoparesis 64.18 14.22 29 18895 1874 29553729
Memory impairment 63.25 14.22 96 18828 36374 29519229
Micturition urgency 63.02 14.22 40 18884 5133 29550470
Stoma site discharge 61.98 14.22 23 18901 894 29554709
Hyperkinesia 59.16 14.22 26 18898 1573 29554030
Movement disorder 56.20 14.22 49 18875 10188 29545415
Impulsive behaviour 54.31 14.22 26 18898 1917 29553686
Encephalitis toxic 51.23 14.22 15 18909 272 29555331
Toxicity to various agents 50.54 14.22 24 18900 173637 29381966
Binge eating 50.52 14.22 12 18912 91 29555512
Muscle spasticity 50.31 14.22 34 18890 4849 29550754
Agitation 50.05 14.22 105 18819 51199 29504404
Psychotic disorder 49.40 14.22 63 18861 20291 29535312
Balance disorder 48.82 14.22 85 18839 36085 29519518
Compulsive hoarding 48.76 14.22 9 18915 14 29555589
Central nervous system lesion 48.11 14.22 35 18889 5613 29549990
Confusional state 48.03 14.22 185 18739 127692 29427911
Dysarthria 47.52 14.22 77 18847 30834 29524769
Stoma site pain 46.34 14.22 16 18908 503 29555100
Tremor 46.32 14.22 127 18797 73411 29482192
Neuroleptic malignant syndrome 45.68 14.22 54 18870 16094 29539509
Aggression 44.72 14.22 81 18843 35460 29520143
Mania 44.63 14.22 40 18884 8623 29546980
Voyeurism 44.49 14.22 7 18917 0 29555603
Dependence 42.11 14.22 18 18906 1017 29554586
Anxiety 41.95 14.22 135 18789 85230 29470373
Sleep attacks 41.55 14.22 11 18913 135 29555468
Delirium 41.20 14.22 83 18841 39314 29516289
Compulsive sexual behaviour 40.56 14.22 12 18912 226 29555377
Febrile neutropenia 40.28 14.22 11 18913 112229 29443374
Neutropenia 40.18 14.22 17 18907 131694 29423909
Somnolence 39.49 14.22 141 18783 93814 29461789
Pyrexia 39.38 14.22 78 18846 287544 29268059
Hyperphagia 38.99 14.22 18 18906 1222 29554381
Dystonia 38.75 14.22 39 18885 9710 29545893
Economic problem 38.72 14.22 18 18906 1242 29554361
Ataxia 38.49 14.22 43 18881 12060 29543543
Hypomania 37.40 14.22 21 18903 2154 29553449
Posture abnormal 36.77 14.22 20 18904 1927 29553676
Acute kidney injury 36.25 14.22 72 18852 265195 29290408
Device dislocation 36.18 14.22 27 18897 4500 29551103
Diarrhoea 36.16 14.22 102 18822 332596 29223007
Multiple sclerosis relapse 35.34 14.22 40 18884 11379 29544224
Restlessness 35.17 14.22 56 18868 22089 29533514
Suspiciousness 33.48 14.22 11 18913 296 29555307
Dementia 32.99 14.22 39 18885 11619 29543984
Paranoia 32.98 14.22 36 18888 9841 29545762
Therapeutic product effect variable 31.94 14.22 18 18906 1859 29553744
Excessive masturbation 31.44 14.22 8 18916 83 29555520
Personality change 31.26 14.22 25 18899 4613 29550990
Sexually inappropriate behaviour 30.57 14.22 11 18913 391 29555212
Bipolar I disorder 30.46 14.22 13 18911 732 29554871
Road traffic accident 29.89 14.22 43 18881 15518 29540085
Platelet count decreased 29.60 14.22 15 18909 104657 29450946
Dizziness 28.96 14.22 214 18710 189470 29366133
Condition aggravated 28.91 14.22 176 18748 146119 29409484
Pollakiuria 28.56 14.22 44 18880 16872 29538731
Akinesia 28.34 14.22 17 18907 1973 29553630
Pancytopenia 28.27 14.22 9 18915 83159 29472444
Acute psychosis 28.22 14.22 16 18908 1671 29553932
Anticholinergic syndrome 28.18 14.22 13 18911 881 29554722
Dropped head syndrome 28.14 14.22 8 18916 130 29555473
Hypervigilance 28.08 14.22 8 18916 131 29555472
Reduced facial expression 27.81 14.22 12 18912 694 29554909
Embedded device 27.79 14.22 9 18915 231 29555372
Somnambulism 27.68 14.22 19 18905 2779 29552824
Obsessive-compulsive personality disorder 27.33 14.22 8 18916 145 29555458
Hallucination, tactile 26.43 14.22 9 18915 271 29555332
Sleep disorder 26.23 14.22 52 18872 24334 29531269
Parkinson's disease 25.76 14.22 14 18910 1347 29554256
Compulsions 25.62 14.22 8 18916 182 29555421
Delusional disorder, jealous type 25.42 14.22 4 18920 0 29555603
Depressive symptom 25.31 14.22 15 18909 1702 29553901
Cognitive disorder 25.15 14.22 50 18874 23449 29532154
Human ehrlichiosis 25.10 14.22 8 18916 195 29555408
Spontaneous penile erection 24.83 14.22 8 18916 202 29555401
Dysstasia 24.75 14.22 32 18892 10442 29545161
Contraindicated product prescribed 24.52 14.22 9 18915 339 29555264
Stoma site haemorrhage 24.41 14.22 11 18913 706 29554897
Disturbance in attention 23.42 14.22 46 18878 21378 29534225
Device occlusion 23.33 14.22 23 18901 5585 29550018
Depression 23.28 14.22 112 18812 85035 29470568
Drug withdrawal syndrome 22.62 14.22 41 18883 17943 29537660
Stoma site inflammation 22.61 14.22 9 18915 424 29555179
Stoma site hypergranulation 22.59 14.22 7 18917 155 29555448
Sleep-related eating disorder 22.41 14.22 8 18916 278 29555325
Inappropriate antidiuretic hormone secretion 22.16 14.22 31 18893 10901 29544702
Cardiac dysfunction 22.08 14.22 14 18910 1793 29553810
Withdrawal syndrome 22.03 14.22 31 18893 10961 29544642
Food interaction 22.03 14.22 11 18913 889 29554714
Sleep apnoea syndrome 21.98 14.22 40 18884 17559 29538044
Rapid eye movements sleep abnormal 21.83 14.22 7 18917 174 29555429
Verbal abuse 21.79 14.22 7 18917 175 29555428
Malignant neoplasm progression 21.77 14.22 10 18914 73849 29481754
Erectile dysfunction 21.33 14.22 40 18884 17969 29537634
Device issue 20.33 14.22 25 18899 7755 29547848
Parkinsonism 20.02 14.22 24 18900 7254 29548349
Bradycardia 19.90 14.22 89 18835 65540 29490063
White blood cell count decreased 19.35 14.22 15 18909 83347 29472256
Abnormal dreams 19.33 14.22 23 18901 6897 29548706
Sepsis 19.20 14.22 39 18885 142643 29412960
Motor dysfunction 18.73 14.22 21 18903 5909 29549694
Marital problem 18.69 14.22 5 18919 64 29555539
Nightmare 18.30 14.22 29 18895 11388 29544215
Suicidal ideation 18.02 14.22 56 18868 34660 29520943
Sexual activity increased 17.95 14.22 4 18920 22 29555581
Cardiac arrest 17.92 14.22 17 18907 85574 29470029
Eosinophilic fasciitis 17.90 14.22 5 18919 76 29555527
Sopor 17.84 14.22 28 18896 10906 29544697
Visual impairment 17.39 14.22 50 18874 29658 29525945
Torticollis 17.29 14.22 10 18914 1085 29554518
Gait inability 17.19 14.22 37 18887 18338 29537265
Lung hyperinflation 17.19 14.22 9 18915 803 29554800
Hyperkalaemia 17.05 14.22 9 18915 61383 29494220
Device kink 17 14.22 7 18917 360 29555243
Device effect decreased 16.99 14.22 3 18921 3 29555600
Intentional medical device removal by patient 16.93 14.22 6 18918 204 29555399
Device alarm issue 16.91 14.22 8 18916 574 29555029
Mobility decreased 16.68 14.22 45 18879 25735 29529868
Tension 16.62 14.22 12 18912 1901 29553702
Disease progression 16.31 14.22 17 18907 81899 29473704
Neutrophil count decreased 16.13 14.22 4 18920 43563 29512040
Rash 15.91 14.22 65 18859 189754 29365849
Mental impairment 15.74 14.22 24 18900 9117 29546486
Troponin increased 15.66 14.22 24 18900 9159 29546444
Stoma site infection 15.48 14.22 8 18916 695 29554908
Rapid eye movement sleep behaviour disorder 15.42 14.22 5 18919 129 29555474
Interstitial lung disease 15.25 14.22 9 18915 57709 29497894
Therapeutic response shortened 15.19 14.22 17 18907 4774 29550829
Paedophilia 15.17 14.22 3 18921 8 29555595
Excessive exercise 15.17 14.22 3 18921 8 29555595
Pleurothotonus 15.12 14.22 9 18915 1029 29554574
Micturition disorder 14.44 14.22 11 18913 1890 29553713
Anaemia 14.34 14.22 73 18851 200878 29354725
Ascites 14.28 14.22 3 18921 36616 29518987
IVth nerve paresis 14.24 14.22 3 18921 12 29555591

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Impulse-control disorder 719.08 11.43 170 37084 1418 64460060
Gambling disorder 599.38 11.43 152 37102 1742 64459736
Dyskinesia 526.20 11.43 311 36943 39077 64422401
Hallucination 422.35 11.43 344 36910 72444 64389034
Hypersexuality 391.60 11.43 103 37151 1376 64460102
On and off phenomenon 376.09 11.43 112 37142 2407 64459071
Hallucination, visual 276.09 11.43 182 37072 27652 64433826
Compulsive shopping 263.90 11.43 66 37188 711 64460767
Dopamine dysregulation syndrome 231.11 11.43 54 37200 425 64461053
Parkinsonism hyperpyrexia syndrome 211.48 11.43 44 37210 186 64461292
Gambling 184.85 11.43 41 37213 248 64461230
Jealous delusion 149.58 11.43 33 37221 194 64461284
Stereotypy 145.77 11.43 42 37212 800 64460678
Freezing phenomenon 136.25 11.43 46 37208 1500 64459978
Dystonia 134.90 11.43 101 37153 18764 64442714
Restless legs syndrome 129.95 11.43 95 37159 17021 64444457
Bradykinesia 129.31 11.43 67 37187 6493 64454985
Delusion 116.83 11.43 91 37163 17923 64443555
Fall 114.56 11.43 510 36744 416316 64045162
Muscle rigidity 110.58 11.43 87 37167 17386 64444092
Stoma site erythema 109.72 11.43 37 37217 1202 64460276
Obsessive-compulsive disorder 108.96 11.43 54 37200 4764 64456714
Stoma site discharge 102.32 11.43 38 37216 1644 64459834
Hyperkinesia 100.28 11.43 42 37212 2504 64458974
Tremor 96.44 11.43 243 37011 147987 64313491
Psychotic disorder 94.36 11.43 108 37146 34470 64427008
Binge eating 94.01 11.43 26 37228 424 64461054
Compulsive hoarding 91.06 11.43 18 37236 55 64461423
Neuroleptic malignant syndrome 91.05 11.43 91 37163 24905 64436573
Sudden onset of sleep 86.49 11.43 26 37228 577 64460901
Pleurothotonus 84.10 11.43 36 37218 2266 64459212
Needle fatigue 82.82 11.43 25 37229 563 64460915
Stoma site pain 81.61 11.43 29 37225 1104 64460374
Abnormal behaviour 80.13 11.43 98 37156 33524 64427954
Gait disturbance 77.47 11.43 247 37007 171908 64289570
Gait spastic 72.58 11.43 25 37229 867 64460611
Therapeutic response shortened 69.49 11.43 53 37201 10117 64451361
Acute psychosis 67.35 11.43 36 37218 3716 64457762
Relapsing-remitting multiple sclerosis 67.28 11.43 25 37229 1083 64460395
Torticollis 66.43 11.43 30 37224 2147 64459331
Akinesia 65.18 11.43 33 37221 3046 64458432
Orthostatic hypotension 64.70 11.43 105 37149 46633 64414845
Febrile neutropenia 63.84 11.43 15 37239 187642 64273836
Delirium 63.41 11.43 130 37124 69064 64392414
Paraphilia 63.05 11.43 13 37241 52 64461426
Camptocormia 61.56 11.43 19 37235 462 64461016
Insomnia 59.46 11.43 249 37005 197587 64263891
Sleep attacks 59.36 11.43 15 37239 169 64461309
Nocturia 58.88 11.43 50 37204 11115 64450363
Neutropenia 58.24 11.43 33 37221 239591 64221887
Movement disorder 55.48 11.43 66 37188 21934 64439544
Psychomotor hyperactivity 55.20 11.43 54 37200 14397 64447081
Impulsive behaviour 54.79 11.43 28 37226 2635 64458843
Toxicity to various agents 52.04 11.43 81 37173 363432 64098046
Anxiety 51.77 11.43 243 37011 202406 64259072
Therapeutic product effect variable 51.26 11.43 23 37231 1621 64459857
Dropped head syndrome 50.47 11.43 14 37240 231 64461247
Drug withdrawal syndrome 49.85 11.43 75 37179 31216 64430262
Monoparesis 49.45 11.43 27 37227 2907 64458571
Posture abnormal 48.33 11.43 28 37226 3378 64458100
Encephalitis toxic 48.08 11.43 14 37240 277 64461201
Suspiciousness 45.90 11.43 16 37238 575 64460903
Hypertonic bladder 45.61 11.43 27 37227 3391 64458087
Memory impairment 44.16 11.43 129 37125 85553 64375925
Micturition urgency 42.00 11.43 40 37214 10319 64451159
Cognitive disorder 41.89 11.43 96 37158 54991 64406487
Restlessness 41.57 11.43 79 37175 39706 64421772
Somnolence 41.36 11.43 229 37025 203416 64258062
Parkinsonism 41.08 11.43 46 37208 14327 64447151
Agitation 40.81 11.43 128 37126 88239 64373239
Pancytopenia 40.54 11.43 16 37238 143293 64318185
Drug dispensed to wrong patient 40.38 11.43 13 37241 364 64461114
Libido increased 40.29 11.43 20 37234 1770 64459708
Voyeurism 38.74 11.43 6 37248 0 64461478
Malignant neoplasm progression 38.42 11.43 9 37245 112862 64348616
Confusional state 38.23 11.43 270 36984 260874 64200604
Aggression 37.87 11.43 83 37171 46149 64415329
Economic problem 36.51 11.43 20 37234 2167 64459311
Rash 36.45 11.43 139 37115 458410 64003068
Hyperphagia 36.14 11.43 20 37234 2211 64459267
Medication error 35.72 11.43 85 37169 49881 64411597
Withdrawal syndrome 35.57 11.43 55 37199 23437 64438041
Multiple sclerosis relapse 35.01 11.43 75 37179 41060 64420418
Balance disorder 34.63 11.43 117 37137 83809 64377669
Depressive symptom 34.22 11.43 25 37229 4471 64457007
Central nervous system lesion 34.00 11.43 38 37216 11811 64449667
Pyrexia 33.91 11.43 187 37067 558457 63903021
Synovitis 33.53 11.43 8 37246 99082 64362396
Compulsions 33.29 11.43 11 37243 335 64461143
Nightmare 32.98 11.43 50 37204 20943 64440535
Abnormal dreams 32.83 11.43 35 37219 10321 64451157
Diarrhoea 32.79 11.43 264 36990 722440 63739038
Acute kidney injury 32.67 11.43 141 37113 449099 64012379
Reduced facial expression 31.67 11.43 18 37236 2095 64459383
Multiple drug therapy 30.58 11.43 18 37236 2236 64459242
Dementia 30.58 11.43 48 37206 20718 64440760
Mania 30.26 11.43 42 37212 16244 64445234
Condition aggravated 30.06 11.43 338 36916 372088 64089390
Dizziness 29.30 11.43 378 36876 429785 64031693
Contraindicated product administered 28.95 11.43 13 37241 107816 64353662
Depressed mood 28.49 11.43 69 37185 40943 64420535
Stoma site infection 28.39 11.43 14 37240 1221 64460257
Excessive masturbation 28.37 11.43 7 37247 71 64461407
Inappropriate antidiuretic hormone secretion 28.06 11.43 48 37206 22241 64439237
Malignant polyp 27.30 11.43 8 37246 162 64461316
Oedema peripheral 26.53 11.43 210 37044 210107 64251371
Sexually inappropriate behaviour 26.38 11.43 10 37244 458 64461020
Platelet count decreased 26.29 11.43 35 37219 167676 64293802
Blood pressure inadequately controlled 26.14 11.43 23 37231 5361 64456117
Dependence 26.11 11.43 16 37238 2139 64459339
Delusional disorder, jealous type 25.83 11.43 4 37250 0 64461478
Dysarthria 25.55 11.43 84 37170 59322 64402156
Personality change 25.41 11.43 28 37226 8565 64452913
Marital problem 25.23 11.43 8 37246 213 64461265
Sleep apnoea syndrome 24.93 11.43 54 37200 29778 64431700
Obsessive-compulsive personality disorder 24.82 11.43 7 37247 123 64461355
Bronchopulmonary aspergillosis allergic 24.80 11.43 14 37240 1608 64459870
Snoring 24.75 11.43 21 37233 4661 64456817
Compulsive sexual behaviour 24.26 11.43 8 37246 242 64461236
Erectile dysfunction 24.12 11.43 33 37221 12594 64448884
Total lung capacity decreased 24.02 11.43 14 37240 1708 64459770
Bipolar I disorder 23.66 11.43 14 37240 1757 64459721
Kleptomania 23.51 11.43 5 37249 24 64461454
Pericarditis 23.32 11.43 4 37250 62512 64398966
Diabetes mellitus inadequate control 23.09 11.43 43 37211 21278 64440200
Product prescribing error 23.08 11.43 58 37196 35211 64426267
Joint swelling 22.98 11.43 57 37197 215325 64246153
Pituitary haemorrhage 22.83 11.43 8 37246 292 64461186
Stomatitis 22.70 11.43 18 37236 109587 64351891
Hallucination, tactile 22.55 11.43 9 37245 474 64461004
Cardiac arrest 22.32 11.43 34 37220 154030 64307448
Orthostatic intolerance 22.30 11.43 13 37241 1587 64459891
Device occlusion 22.18 11.43 28 37226 9885 64451593
Maternal exposure during pregnancy 22.15 11.43 14 37240 95870 64365608
Chorea 22.09 11.43 14 37240 1986 64459492
Ataxia 22.02 11.43 43 37211 22041 64439437
Troponin increased 21.85 11.43 35 37219 15364 64446114
Vaccination site bruising 21.79 11.43 4 37250 7 64461471
Vaccination site oedema 21.44 11.43 4 37250 8 64461470
Vaccination site pruritus 21.44 11.43 4 37250 8 64461470
Hand deformity 21.36 11.43 5 37249 62766 64398712
Human ehrlichiosis 20.89 11.43 8 37246 377 64461101
Treatment failure 20.85 11.43 22 37232 116794 64344684
Pollakiuria 20.79 11.43 52 37202 31478 64430000
Autonomic nervous system imbalance 20.76 11.43 18 37236 4114 64457364
Spontaneous penile erection 20.74 11.43 6 37248 116 64461362
Food interaction 20.66 11.43 12 37242 1454 64460024
Paranoia 20.30 11.43 35 37219 16317 64445161
Product residue present 20.20 11.43 16 37238 3226 64458252
Rapid eye movements sleep abnormal 20.12 11.43 7 37247 250 64461228
Verbal abuse 19.94 11.43 7 37247 257 64461221
Drug intolerance 19.85 11.43 50 37204 187942 64273536
Muscle spasticity 19.81 11.43 35 37219 16634 64444844
Hyperventilation 19.73 11.43 22 37232 6818 64454660
Vestibular migraine 19.67 11.43 6 37248 140 64461338
Device dislocation 19.64 11.43 40 37214 21138 64440340
Hypomania 19.52 11.43 20 37234 5634 64455844
Hypervigilance 19.47 11.43 8 37246 454 64461024
Hypersensitivity 19.42 11.43 54 37200 196398 64265080
Mucosal inflammation 19.39 11.43 6 37248 62578 64398900
Dysstasia 19.37 11.43 42 37212 23173 64438305
Paedophilia 19.37 11.43 3 37251 0 64461478
Device kink 19.07 11.43 12 37242 1681 64459797
Glossodynia 18.66 11.43 7 37247 64689 64396789
Lung opacity 18.26 11.43 15 37239 3184 64458294
White blood cell count decreased 18.25 11.43 40 37214 157797 64303681
Product substitution issue 18.08 11.43 35 37219 17826 64443652
Therapeutic response unexpected 18.06 11.43 34 37220 16967 64444511
Bone marrow failure 18.04 11.43 3 37251 47949 64413529
Disease progression 18.00 11.43 34 37220 141646 64319832
Stoma site inflammation 17.80 11.43 8 37246 566 64460912
Thrombocytopenia 17.64 11.43 68 37186 223733 64237745
Disturbance in attention 17.59 11.43 58 37196 41016 64420462
Female orgasmic disorder 17.41 11.43 4 37250 29 64461449
Ascites 17.40 11.43 7 37247 61994 64399484
Urticaria 17.31 11.43 37 37217 147280 64314198
Stoma site hypergranulation 17.18 11.43 7 37247 389 64461089
Suicidal ideation 17.10 11.43 80 37174 66462 64395016
Hepatocellular injury 16.64 11.43 3 37251 45232 64416246
Drug hypersensitivity 16.43 11.43 76 37178 237739 64223739
Anticholinergic syndrome 16.26 11.43 13 37241 2656 64458822
Sleep disorder 16.25 11.43 73 37181 59636 64401842
Obsessive thoughts 16.15 11.43 9 37245 1008 64460470
Serum serotonin increased 15.89 11.43 6 37248 272 64461206
Discomfort 15.86 11.43 14 37240 80864 64380614
Device issue 15.61 11.43 38 37216 22610 64438868
Feeling abnormal 15.53 11.43 131 37123 133471 64328007
Prescribed underdose 15.50 11.43 33 37221 17982 64443496
Alanine aminotransferase increased 15.45 11.43 36 37218 138995 64322483
Drug reaction with eosinophilia and systemic symptoms 15.41 11.43 6 37248 54211 64407267
Hepatic function abnormal 15.40 11.43 9 37245 64304 64397174
Intentional medical device removal by patient 15.25 11.43 6 37248 304 64461174
Delusion of replacement 15.20 11.43 5 37249 150 64461328
Vaccination site erythema 15.16 11.43 4 37250 54 64461424
Choking 15.02 11.43 24 37230 10514 64450964
Contraindicated product prescribed 15 11.43 9 37245 1158 64460320
Stoma site candida 14.98 11.43 3 37251 10 64461468
Parkinson's disease 14.73 11.43 10 37244 1591 64459887
Hiccups 14.67 11.43 21 37233 8355 64453123
Cardiac dysfunction 14.54 11.43 13 37241 3093 64458385
Orgasm abnormal 14.53 11.43 5 37249 173 64461305
Exercise tolerance decreased 14.50 11.43 20 37234 7690 64453788
Off label use 14.48 11.43 268 36986 632538 63828940
Micturition disorder 14.39 11.43 13 37241 3135 64458343
Neutrophil count decreased 14.38 11.43 14 37240 77182 64384296
Blood calcium increased 14.35 11.43 21 37233 8521 64452957
Coronary artery dissection 14.31 11.43 8 37246 902 64460576
Rheumatoid arthritis 14.21 11.43 48 37206 164246 64297232
Alopecia 13.93 11.43 49 37205 165641 64295837
Vaccination site pain 13.79 11.43 4 37250 78 64461400
Eosinophilic fasciitis 13.76 11.43 5 37249 203 64461275
Arthropathy 13.70 11.43 31 37223 120936 64340542
Blister 13.62 11.43 16 37238 80951 64380527
Infusion related reaction 13.59 11.43 49 37205 164418 64297060
Stoma site irritation 13.56 11.43 5 37249 212 64461266
Sleep-related eating disorder 13.54 11.43 7 37247 675 64460803
Hypersomnia 13.50 11.43 33 37221 19684 64441794
Fibroma 13.47 11.43 7 37247 682 64460796
Underdose 13.40 11.43 39 37215 25790 64435688
Nasopharyngitis 13.34 11.43 63 37191 196010 64265468
Depression 13.26 11.43 163 37091 183128 64278350
Heat stroke 13.18 11.43 9 37245 1446 64460032
Amnesia 13.12 11.43 59 37195 48210 64413268
Speech disorder 13.01 11.43 59 37195 48382 64413096
Inhibitory drug interaction 12.83 11.43 13 37241 3614 64457864
Interstitial lung disease 12.81 11.43 23 37231 97709 64363769
Anisomastia 12.79 11.43 3 37251 24 64461454
Middle insomnia 12.75 11.43 25 37229 12852 64448626
Abdominal discomfort 12.74 11.43 58 37196 182264 64279214
Sexual activity increased 12.69 11.43 3 37251 25 64461453
Irritable bowel syndrome 12.67 11.43 3 37251 37366 64424112
Apathy 12.60 11.43 23 37231 11209 64450269
Excessive exercise 12.48 11.43 3 37251 27 64461451
Bladder sphincter atony 12.46 11.43 4 37250 111 64461367
Irritability 12.41 11.43 48 37206 36698 64424780
Motor dysfunction 12.40 11.43 23 37231 11350 64450128
Sepsis 12.39 11.43 80 37174 230261 64231217
Meningorrhagia 12.37 11.43 5 37249 272 64461206
Lung hyperinflation 12.35 11.43 9 37245 1603 64459875
Stoma site haemorrhage 12.35 11.43 9 37245 1604 64459874
Somnambulism 12.27 11.43 15 37239 5126 64456352
Euphoric mood 12.25 11.43 17 37237 6574 64454904
Mobility decreased 12.09 11.43 88 37166 85752 64375726
Hepatotoxicity 12.08 11.43 4 37250 39958 64421520
Stoma site extravasation 12.00 11.43 5 37249 294 64461184
Road traffic accident 11.92 11.43 42 37212 30703 64430775
Sopor 11.92 11.43 41 37213 29620 64431858
Hepatic enzyme increased 11.90 11.43 37 37217 129906 64331572
Device connection issue 11.88 11.43 7 37247 872 64460606

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N04BC05 NERVOUS SYSTEM
ANTI-PARKINSON DRUGS
DOPAMINERGIC AGENTS
Dopamine agonists
FDA MoA N0000000117 Dopamine Agonists
MeSH PA D018726 Anti-Dyskinesia Agents
MeSH PA D000975 Antioxidants
MeSH PA D000978 Antiparkinson Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D015259 Dopamine Agents
MeSH PA D018491 Dopamine Agonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D020011 Protective Agents
CHEBI has role CHEBI:48407 antiparkinson agent
CHEBI has role CHEBI:48578 free radical scavengers
CHEBI has role CHEBI:51065 Dopamine receptor agonist
CHEBI has role CHEBI:66956 antidyskinetic agent
FDA EPC N0000175768 Nonergot Dopamine Agonist

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Restless legs indication 32914008 DOID:0050425
Parkinson's disease indication 49049000 DOID:14330
Fibromyalgia off-label use 203082005 DOID:631
Hallucinations contraindication 7011001
Dyskinesia contraindication 9748009
Orthostatic hypotension contraindication 28651003
Narcolepsy contraindication 60380001 DOID:8986
Psychotic disorder contraindication 69322001
Sleep apnea contraindication 73430006 DOID:0050847
Kidney disease contraindication 90708001 DOID:557
Drowsy contraindication 271782001
Malignant melanoma contraindication 372244006
Breastfeeding (mother) contraindication 413712001




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.57 Basic
pKa2 5.18 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
0.375MG MIRAPEX ER BOEHRINGER INGELHEIM N022421 Feb. 19, 2010 RX TABLET, EXTENDED RELEASE ORAL 8679533 Sept. 8, 2029 TREATMENT OF PARKINSONS DISEASE
0.75MG MIRAPEX ER BOEHRINGER INGELHEIM N022421 Feb. 19, 2010 RX TABLET, EXTENDED RELEASE ORAL 8679533 Sept. 8, 2029 TREATMENT OF PARKINSONS DISEASE
1.5MG MIRAPEX ER BOEHRINGER INGELHEIM N022421 Feb. 19, 2010 RX TABLET, EXTENDED RELEASE ORAL 8679533 Sept. 8, 2029 TREATMENT OF PARKINSONS DISEASE
2.25MG MIRAPEX ER BOEHRINGER INGELHEIM N022421 June 17, 2011 RX TABLET, EXTENDED RELEASE ORAL 8679533 Sept. 8, 2029 TREATMENT OF PARKINSONS DISEASE
3.75MG MIRAPEX ER BOEHRINGER INGELHEIM N022421 June 17, 2011 RX TABLET, EXTENDED RELEASE ORAL 8679533 Sept. 8, 2029 TREATMENT OF PARKINSONS DISEASE
3MG MIRAPEX ER BOEHRINGER INGELHEIM N022421 Feb. 19, 2010 RX TABLET, EXTENDED RELEASE ORAL 8679533 Sept. 8, 2029 TREATMENT OF PARKINSONS DISEASE
4.5MG MIRAPEX ER BOEHRINGER INGELHEIM N022421 Feb. 19, 2010 RX TABLET, EXTENDED RELEASE ORAL 8679533 Sept. 8, 2029 TREATMENT OF PARKINSONS DISEASE

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(2) dopamine receptor GPCR AGONIST EC50 6.60 WOMBAT-PK CHEMBL
Beta-2 adrenergic receptor GPCR Ki 4 CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 7.12 PDSP
5-hydroxytryptamine receptor 1A GPCR Ki 6.16 WOMBAT-PK
5-hydroxytryptamine receptor 2A GPCR EC50 5.93 CHEMBL
5-hydroxytryptamine receptor 7 GPCR Ki 5.93 PDSP
Alpha-2B adrenergic receptor GPCR Ki 6.20 WOMBAT-PK
D(3) dopamine receptor GPCR AGONIST EC50 8.67 WOMBAT-PK
Histamine H2 receptor GPCR Ki 5.57 PDSP
5-hydroxytryptamine receptor 1B GPCR Ki 5.46 PDSP
5-hydroxytryptamine receptor 1D GPCR Ki 5.78 PDSP
Alpha-2C adrenergic receptor GPCR Ki 7.28 PDSP
D(4) dopamine receptor GPCR AGONIST Ki 9.31 CHEMBL
D(2) dopamine receptor GPCR Ki 8.51 CHEMBL
D(2) dopamine receptor GPCR Kd 8.80 CHEMBL
D(3) dopamine receptor GPCR Ki 9.35 CHEMBL

External reference:

IDSource
4024071 VUID
N0000022076 NUI
D00559 KEGG_DRUG
191217-81-9 SECONDARY_CAS_RN
4021042 VANDF
4024071 VANDF
C0074710 UMLSCUI
CHEBI:8356 CHEBI
G6L PDB_CHEM_ID
CHEMBL301265 ChEMBL_ID
DB00413 DRUGBANK_ID
CHEMBL3182733 ChEMBL_ID
CHEMBL542257 ChEMBL_ID
D000077487 MESH_DESCRIPTOR_UI
119570 PUBCHEM_CID
6227 INN_ID
953 IUPHAR_LIGAND_ID
83619PEU5T UNII
236747 RXNORM
169631 MMSL
23370 MMSL
5340 MMSL
d04145 MMSL
006721 NDDF
006722 NDDF
108471007 SNOMEDCT_US
386852009 SNOMEDCT_US
412282004 SNOMEDCT_US
725650009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Mirapex ER HUMAN PRESCRIPTION DRUG LABEL 1 0597-0109 TABLET, EXTENDED RELEASE 0.38 mg ORAL NDA 32 sections
Mirapex ER HUMAN PRESCRIPTION DRUG LABEL 1 0597-0113 TABLET, EXTENDED RELEASE 1.50 mg ORAL NDA 32 sections
Mirapex ER HUMAN PRESCRIPTION DRUG LABEL 1 0597-0115 TABLET, EXTENDED RELEASE 3 mg ORAL NDA 32 sections
Mirapex ER HUMAN PRESCRIPTION DRUG LABEL 1 0597-0116 TABLET, EXTENDED RELEASE 4.50 mg ORAL NDA 32 sections
Mirapex ER HUMAN PRESCRIPTION DRUG LABEL 1 0597-0285 TABLET, EXTENDED RELEASE 0.75 mg ORAL NDA 32 sections
Mirapex ER HUMAN PRESCRIPTION DRUG LABEL 1 0597-0286 TABLET, EXTENDED RELEASE 2.25 mg ORAL NDA 32 sections
Mirapex ER HUMAN PRESCRIPTION DRUG LABEL 1 0597-0287 TABLET, EXTENDED RELEASE 3.75 mg ORAL NDA 32 sections
Pramipexole Dihydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-7597 TABLET 1 mg ORAL ANDA 28 sections
Pramipexole Dihydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6704 TABLET 0.25 mg ORAL ANDA 20 sections
Pramipexole Dihydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6704 TABLET 0.25 mg ORAL ANDA 20 sections
Pramipexole DihydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-251 TABLET, EXTENDED RELEASE 0.38 mg ORAL ANDA 28 sections
Pramipexole DihydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-251 TABLET, EXTENDED RELEASE 0.38 mg ORAL ANDA 28 sections
Pramipexole DihydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-252 TABLET, EXTENDED RELEASE 0.75 mg ORAL ANDA 28 sections
Pramipexole DihydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-252 TABLET, EXTENDED RELEASE 0.75 mg ORAL ANDA 28 sections
Pramipexole DihydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-253 TABLET, EXTENDED RELEASE 1.50 mg ORAL ANDA 28 sections
Pramipexole DihydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-253 TABLET, EXTENDED RELEASE 1.50 mg ORAL ANDA 28 sections
Pramipexole DihydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-254 TABLET, EXTENDED RELEASE 3 mg ORAL ANDA 28 sections
Pramipexole DihydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-254 TABLET, EXTENDED RELEASE 3 mg ORAL ANDA 28 sections
Pramipexole DihydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-255 TABLET, EXTENDED RELEASE 4.50 mg ORAL ANDA 28 sections
Pramipexole DihydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-255 TABLET, EXTENDED RELEASE 4.50 mg ORAL ANDA 28 sections
Pramipexole DihydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-305 TABLET, EXTENDED RELEASE 2.25 mg ORAL ANDA 28 sections
Pramipexole DihydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-305 TABLET, EXTENDED RELEASE 2.25 mg ORAL ANDA 28 sections
Pramipexole DihydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-306 TABLET, EXTENDED RELEASE 3.75 mg ORAL ANDA 28 sections
Pramipexole DihydrochlorideExtended-Release HUMAN PRESCRIPTION DRUG LABEL 1 10370-306 TABLET, EXTENDED RELEASE 3.75 mg ORAL ANDA 28 sections
Pramipexole Dihydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 13668-091 TABLET 0.13 mg ORAL ANDA 20 sections
Pramipexole Dihydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 13668-091 TABLET 0.13 mg ORAL ANDA 20 sections
Pramipexole Dihydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 13668-092 TABLET 0.25 mg ORAL ANDA 20 sections
Pramipexole Dihydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 13668-092 TABLET 0.25 mg ORAL ANDA 20 sections
Pramipexole Dihydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 13668-093 TABLET 0.50 mg ORAL ANDA 20 sections
Pramipexole Dihydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 13668-093 TABLET 0.50 mg ORAL ANDA 20 sections