Stem definition | Drug id | CAS RN |
---|---|---|
2233 | 104632-26-0 |
Dose | Unit | Route |
---|---|---|
2.50 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.20 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 90 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.30 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 93 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 7 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 7.20 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.85 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 12.40 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
July 1, 1997 | FDA | BOEHRINGER INGELHEIM |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Gambling disorder | 476.44 | 11.68 | 115 | 31346 | 1096 | 56259510 |
Dyskinesia | 393.58 | 11.68 | 229 | 31232 | 28879 | 56231727 |
Restless legs syndrome | 319.24 | 11.68 | 166 | 31295 | 16781 | 56243825 |
Impulse-control disorder | 312.05 | 11.68 | 74 | 31387 | 649 | 56259957 |
Compulsive shopping | 296.08 | 11.68 | 71 | 31390 | 656 | 56259950 |
On and off phenomenon | 270.39 | 11.68 | 78 | 31383 | 1546 | 56259060 |
Hallucination | 233.00 | 11.68 | 204 | 31257 | 48945 | 56211661 |
Hallucination, visual | 173.65 | 11.68 | 113 | 31348 | 17355 | 56243251 |
Gambling | 153.93 | 11.68 | 34 | 31427 | 209 | 56260397 |
Parkinsonism hyperpyrexia syndrome | 131.45 | 11.68 | 27 | 31434 | 110 | 56260496 |
Dystonia | 127.50 | 11.68 | 82 | 31379 | 12339 | 56248267 |
Tremor | 123.17 | 11.68 | 233 | 31228 | 120856 | 56139750 |
Hypersexuality | 116.72 | 11.68 | 31 | 31430 | 446 | 56260160 |
Freezing phenomenon | 114.68 | 11.68 | 37 | 31424 | 1080 | 56259526 |
Stoma site discharge | 106.43 | 11.68 | 37 | 31424 | 1365 | 56259241 |
Muscle rigidity | 93.90 | 11.68 | 64 | 31397 | 10607 | 56249999 |
Pleurothotonus | 93.15 | 11.68 | 33 | 31428 | 1288 | 56259318 |
Stoma site erythema | 93.11 | 11.68 | 31 | 31430 | 1001 | 56259605 |
Bradykinesia | 92.66 | 11.68 | 48 | 31413 | 4806 | 56255800 |
Obsessive-compulsive disorder | 92.57 | 11.68 | 44 | 31417 | 3662 | 56256944 |
Sudden onset of sleep | 89.56 | 11.68 | 26 | 31435 | 527 | 56260079 |
Systemic lupus erythematosus | 87.26 | 11.68 | 3 | 31458 | 180075 | 56080531 |
Stoma site pain | 85.80 | 11.68 | 28 | 31433 | 848 | 56259758 |
Stereotypy | 82.59 | 11.68 | 23 | 31438 | 399 | 56260207 |
Binge eating | 73.56 | 11.68 | 21 | 31440 | 400 | 56260206 |
Camptocormia | 70.99 | 11.68 | 19 | 31442 | 282 | 56260324 |
Fall | 70.54 | 11.68 | 389 | 31072 | 357121 | 55903485 |
Orthostatic hypotension | 66.06 | 11.68 | 87 | 31374 | 33112 | 56227494 |
Jealous delusion | 63.45 | 11.68 | 12 | 31449 | 28 | 56260578 |
Glossodynia | 63.39 | 11.68 | 6 | 31455 | 152452 | 56108154 |
Maternal exposure during pregnancy | 57.96 | 11.68 | 17 | 31444 | 189536 | 56071070 |
Hyperkinesia | 55.30 | 11.68 | 24 | 31437 | 1615 | 56258991 |
Therapeutic response shortened | 54.85 | 11.68 | 44 | 31417 | 9342 | 56251264 |
Delusion | 53.99 | 11.68 | 47 | 31414 | 11168 | 56249438 |
Parkinson's disease | 53.06 | 11.68 | 22 | 31439 | 1322 | 56259284 |
Compulsive hoarding | 52.58 | 11.68 | 11 | 31450 | 50 | 56260556 |
Rheumatoid arthritis | 51.62 | 11.68 | 84 | 31377 | 382520 | 55878086 |
Psychotic disorder | 50.41 | 11.68 | 64 | 31397 | 23494 | 56237112 |
Acute psychosis | 50.37 | 11.68 | 25 | 31436 | 2287 | 56258319 |
Pericarditis | 48.90 | 11.68 | 3 | 31458 | 108920 | 56151686 |
Drug dispensed to wrong patient | 48.19 | 11.68 | 13 | 31448 | 199 | 56260407 |
Hand deformity | 47.13 | 11.68 | 9 | 31452 | 134483 | 56126123 |
Torticollis | 47.08 | 11.68 | 22 | 31439 | 1761 | 56258845 |
Diabetes mellitus inadequate control | 46.98 | 11.68 | 48 | 31413 | 13932 | 56246674 |
Alopecia | 45.90 | 11.68 | 58 | 31403 | 293400 | 55967206 |
Abnormal dreams | 45.57 | 11.68 | 40 | 31421 | 9609 | 56250997 |
Neuroleptic malignant syndrome | 45.25 | 11.68 | 43 | 31418 | 11435 | 56249171 |
Somnolence | 45.18 | 11.68 | 196 | 31265 | 163217 | 56097389 |
Contraindicated product administered | 43.55 | 11.68 | 25 | 31436 | 186261 | 56074345 |
Gait disturbance | 41.46 | 11.68 | 191 | 31270 | 163130 | 56097476 |
Abnormal behaviour | 40.13 | 11.68 | 53 | 31408 | 20219 | 56240387 |
Parkinsonism | 40.01 | 11.68 | 37 | 31424 | 9509 | 56251097 |
Medication error | 38.75 | 11.68 | 78 | 31383 | 42257 | 56218349 |
Vestibular migraine | 38.07 | 11.68 | 11 | 31450 | 219 | 56260387 |
Sleep attacks | 38.04 | 11.68 | 9 | 31452 | 78 | 56260528 |
Akinesia | 37.64 | 11.68 | 18 | 31443 | 1518 | 56259088 |
Febrile neutropenia | 37.11 | 11.68 | 7 | 31454 | 105538 | 56155068 |
Stoma site infection | 36.15 | 11.68 | 14 | 31447 | 703 | 56259903 |
Discomfort | 36.13 | 11.68 | 17 | 31444 | 141744 | 56118862 |
Psychomotor hyperactivity | 35.35 | 11.68 | 35 | 31426 | 9785 | 56250821 |
Total lung capacity decreased | 35.12 | 11.68 | 17 | 31444 | 1472 | 56259134 |
Dependence | 33.17 | 11.68 | 18 | 31443 | 1979 | 56258627 |
Bronchopulmonary aspergillosis allergic | 32.58 | 11.68 | 16 | 31445 | 1430 | 56259176 |
Multiple drug therapy | 32.58 | 11.68 | 20 | 31441 | 2772 | 56257834 |
Blood pressure inadequately controlled | 32.55 | 11.68 | 24 | 31437 | 4500 | 56256106 |
Pituitary haemorrhage | 32.18 | 11.68 | 8 | 31453 | 87 | 56260519 |
Insomnia | 32.04 | 11.68 | 200 | 31261 | 191660 | 56068946 |
Swelling | 31.95 | 11.68 | 53 | 31408 | 239718 | 56020888 |
Dopamine dysregulation syndrome | 31.75 | 11.68 | 9 | 31452 | 167 | 56260439 |
Dropped head syndrome | 31.08 | 11.68 | 8 | 31453 | 101 | 56260505 |
Malignant polyp | 31.07 | 11.68 | 9 | 31452 | 181 | 56260425 |
Anxiety | 30.79 | 11.68 | 199 | 31262 | 192973 | 56067633 |
Lung opacity | 30.50 | 11.68 | 18 | 31443 | 2323 | 56258283 |
Drug intolerance | 29.63 | 11.68 | 65 | 31396 | 264753 | 55995853 |
Synovitis | 29.47 | 11.68 | 28 | 31433 | 161277 | 56099329 |
Delirium | 29.42 | 11.68 | 70 | 31391 | 42447 | 56218159 |
Rash | 28.79 | 11.68 | 160 | 31301 | 492887 | 55767719 |
Fibroma | 28.55 | 11.68 | 12 | 31449 | 746 | 56259860 |
Economic problem | 28.38 | 11.68 | 16 | 31445 | 1895 | 56258711 |
Abdominal discomfort | 27.89 | 11.68 | 72 | 31389 | 277202 | 55983404 |
Exercise tolerance decreased | 27.73 | 11.68 | 23 | 31438 | 5115 | 56255491 |
Memory impairment | 27.17 | 11.68 | 108 | 31353 | 86449 | 56174157 |
Neutropenia | 27.13 | 11.68 | 29 | 31432 | 158138 | 56102468 |
Joint swelling | 27.09 | 11.68 | 78 | 31383 | 289722 | 55970884 |
Product prescribing error | 26.53 | 11.68 | 47 | 31414 | 23139 | 56237467 |
Depressed mood | 26.40 | 11.68 | 61 | 31400 | 36298 | 56224308 |
Hypersensitivity | 26.23 | 11.68 | 66 | 31395 | 256342 | 56004264 |
Hyperventilation | 25.84 | 11.68 | 23 | 31438 | 5625 | 56254981 |
Crime | 25.53 | 11.68 | 5 | 31456 | 15 | 56260591 |
Hyperphagia | 25.44 | 11.68 | 14 | 31447 | 1582 | 56259024 |
Exposure during pregnancy | 24.52 | 11.68 | 24 | 31437 | 136318 | 56124288 |
Orthostatic intolerance | 24.39 | 11.68 | 12 | 31449 | 1077 | 56259529 |
Oedema peripheral | 24.04 | 11.68 | 171 | 31290 | 171083 | 56089523 |
Posture abnormal | 23.77 | 11.68 | 15 | 31446 | 2183 | 56258423 |
Malignant neoplasm progression | 23.60 | 11.68 | 6 | 31455 | 73581 | 56187025 |
Amnesia | 23.58 | 11.68 | 68 | 31393 | 46254 | 56214352 |
Deep brain stimulation | 23.19 | 11.68 | 5 | 31456 | 27 | 56260579 |
Cognitive disorder | 22.99 | 11.68 | 70 | 31391 | 49063 | 56211543 |
Drug interaction | 22.07 | 11.68 | 196 | 31265 | 209559 | 56051047 |
Vaccination site oedema | 21.92 | 11.68 | 4 | 31457 | 7 | 56260599 |
Withdrawal syndrome | 21.87 | 11.68 | 38 | 31423 | 18424 | 56242182 |
Nightmare | 21.74 | 11.68 | 36 | 31425 | 16790 | 56243816 |
Compulsions | 21.61 | 11.68 | 7 | 31454 | 207 | 56260399 |
Vaccination site bruising | 21.57 | 11.68 | 4 | 31457 | 8 | 56260598 |
Vaccination site pruritus | 21.57 | 11.68 | 4 | 31457 | 8 | 56260598 |
Chorea | 21.45 | 11.68 | 12 | 31449 | 1400 | 56259206 |
Snoring | 21.37 | 11.68 | 17 | 31444 | 3564 | 56257042 |
Stomatitis | 20.88 | 11.68 | 22 | 31439 | 120788 | 56139818 |
Restlessness | 20.86 | 11.68 | 46 | 31415 | 26540 | 56234066 |
Movement disorder | 20.80 | 11.68 | 38 | 31423 | 19160 | 56241446 |
Diarrhoea | 20.69 | 11.68 | 243 | 31218 | 638264 | 55622342 |
Pulmonary fibrosis | 20.59 | 11.68 | 49 | 31412 | 29709 | 56230897 |
Therapeutic response changed | 20.58 | 11.68 | 10 | 31451 | 873 | 56259733 |
Stoma site inflammation | 20.48 | 11.68 | 8 | 31453 | 411 | 56260195 |
Sleep apnoea syndrome | 20.34 | 11.68 | 45 | 31416 | 26016 | 56234590 |
Female orgasmic disorder | 20.14 | 11.68 | 5 | 31456 | 54 | 56260552 |
Blister | 19.77 | 11.68 | 19 | 31442 | 108868 | 56151738 |
Muscle injury | 19.51 | 11.68 | 3 | 31458 | 52497 | 56208109 |
Drug withdrawal syndrome | 19.46 | 11.68 | 44 | 31417 | 25813 | 56234793 |
Stoma site hypergranulation | 19.29 | 11.68 | 7 | 31454 | 293 | 56260313 |
Off label use | 19.05 | 11.68 | 209 | 31252 | 555971 | 55704635 |
Heat stroke | 18.98 | 11.68 | 9 | 31452 | 745 | 56259861 |
Serum serotonin increased | 18.90 | 11.68 | 6 | 31455 | 166 | 56260440 |
Prescribed underdose | 18.88 | 11.68 | 38 | 31423 | 20579 | 56240027 |
Aspiration | 18.80 | 11.68 | 25 | 31436 | 9596 | 56251010 |
Blood calcium increased | 18.80 | 11.68 | 23 | 31438 | 8131 | 56252475 |
Coronary artery dissection | 18.72 | 11.68 | 9 | 31452 | 768 | 56259838 |
Product substitution issue | 18.55 | 11.68 | 31 | 31430 | 14568 | 56246038 |
Toxicity to various agents | 18.46 | 11.68 | 64 | 31397 | 224500 | 56036106 |
Product residue present | 18.46 | 11.68 | 16 | 31445 | 3779 | 56256827 |
Depression | 18.27 | 11.68 | 167 | 31294 | 179950 | 56080656 |
Suspiciousness | 18.18 | 11.68 | 7 | 31454 | 346 | 56260260 |
Inhibitory drug interaction | 18.15 | 11.68 | 13 | 31448 | 2331 | 56258275 |
Therapeutic product effect variable | 18.14 | 11.68 | 10 | 31451 | 1134 | 56259472 |
Orgasm abnormal | 18.10 | 11.68 | 5 | 31456 | 84 | 56260522 |
Treatment failure | 18.08 | 11.68 | 43 | 31418 | 170349 | 56090257 |
Ill-defined disorder | 17.79 | 11.68 | 8 | 31453 | 68535 | 56192071 |
Stoma site irritation | 17.29 | 11.68 | 6 | 31455 | 220 | 56260386 |
Wound | 17.27 | 11.68 | 32 | 31429 | 138772 | 56121834 |
Pre-existing condition improved | 17.27 | 11.68 | 21 | 31440 | 7377 | 56253229 |
Conjunctival discolouration | 17.05 | 11.68 | 5 | 31456 | 105 | 56260501 |
Stoma site reaction | 17.04 | 11.68 | 6 | 31455 | 230 | 56260376 |
Narcolepsy | 16.88 | 11.68 | 10 | 31451 | 1299 | 56259307 |
Meningorrhagia | 16.88 | 11.68 | 5 | 31456 | 109 | 56260497 |
Bipolar disorder | 16.86 | 11.68 | 21 | 31440 | 7559 | 56253047 |
Pancytopenia | 16.67 | 11.68 | 15 | 31446 | 88700 | 56171906 |
Suicidal ideation | 16.50 | 11.68 | 70 | 31391 | 57672 | 56202934 |
Granuloma skin | 16.43 | 11.68 | 20 | 31441 | 7031 | 56253575 |
Hypercapnia | 16.22 | 11.68 | 17 | 31444 | 5079 | 56255527 |
Dizziness | 15.98 | 11.68 | 297 | 31164 | 375843 | 55884763 |
Confusional state | 15.86 | 11.68 | 182 | 31279 | 207973 | 56052633 |
Thrombocytopenia | 15.58 | 11.68 | 33 | 31428 | 136191 | 56124415 |
Vaccination site erythema | 15.51 | 11.68 | 4 | 31457 | 51 | 56260555 |
Breath sounds abnormal | 15.49 | 11.68 | 22 | 31439 | 8985 | 56251621 |
Disease progression | 15.18 | 11.68 | 22 | 31439 | 105151 | 56155455 |
Compulsive sexual behaviour | 14.90 | 11.68 | 4 | 31457 | 60 | 56260546 |
Pyrexia | 14.86 | 11.68 | 156 | 31305 | 418617 | 55841989 |
Autonomic nervous system imbalance | 14.82 | 11.68 | 12 | 31449 | 2581 | 56258025 |
Feeling abnormal | 14.64 | 11.68 | 126 | 31335 | 133476 | 56127130 |
Product use issue | 14.64 | 11.68 | 54 | 31407 | 185987 | 56074619 |
Drug abuse | 14.51 | 11.68 | 10 | 31451 | 67600 | 56193006 |
Speech disorder | 14.45 | 11.68 | 50 | 31411 | 37443 | 56223163 |
Nasopharyngitis | 14.38 | 11.68 | 69 | 31392 | 220890 | 56039716 |
Infusion related reaction | 14.33 | 11.68 | 64 | 31397 | 208867 | 56051739 |
Stoma site candida | 14.28 | 11.68 | 3 | 31458 | 14 | 56260592 |
Stoma site haemorrhage | 14.02 | 11.68 | 8 | 31453 | 970 | 56259636 |
Sputum discoloured | 13.88 | 11.68 | 27 | 31434 | 14265 | 56246341 |
Blood parathyroid hormone decreased | 13.75 | 11.68 | 20 | 31441 | 8344 | 56252262 |
Vitamin B6 deficiency | 13.69 | 11.68 | 4 | 31457 | 83 | 56260523 |
Bulimia nervosa | 13.63 | 11.68 | 6 | 31455 | 418 | 56260188 |
Middle insomnia | 13.58 | 11.68 | 23 | 31438 | 10927 | 56249679 |
Irritable bowel syndrome | 13.56 | 11.68 | 11 | 31450 | 68447 | 56192159 |
Balance disorder | 13.52 | 11.68 | 81 | 31380 | 76439 | 56184167 |
Arthropathy | 13.35 | 11.68 | 62 | 31399 | 200213 | 56060393 |
Initial insomnia | 13.29 | 11.68 | 16 | 31445 | 5563 | 56255043 |
Endometrial cancer | 13.19 | 11.68 | 12 | 31449 | 3018 | 56257588 |
Patient elopement | 13.01 | 11.68 | 3 | 31458 | 23 | 56260583 |
Condition aggravated | 12.84 | 11.68 | 267 | 31194 | 344631 | 55915975 |
Muscle atrophy | 12.83 | 11.68 | 17 | 31444 | 6504 | 56254102 |
Mucosal inflammation | 12.78 | 11.68 | 4 | 31457 | 42806 | 56217800 |
Infection | 12.74 | 11.68 | 63 | 31398 | 200143 | 56060463 |
Kleptomania | 12.68 | 11.68 | 3 | 31458 | 26 | 56260580 |
Choking | 12.65 | 11.68 | 20 | 31441 | 8977 | 56251629 |
Panniculitis | 12.64 | 11.68 | 21 | 31440 | 9821 | 56250785 |
Anisomastia | 12.48 | 11.68 | 3 | 31458 | 28 | 56260578 |
Vaccination site pain | 12.29 | 11.68 | 4 | 31457 | 120 | 56260486 |
Stoma site extravasation | 12.13 | 11.68 | 5 | 31456 | 296 | 56260310 |
Muscle rupture | 12.01 | 11.68 | 10 | 31451 | 2236 | 56258370 |
Reduced facial expression | 11.75 | 11.68 | 9 | 31452 | 1787 | 56258819 |
Skull fracture | 11.68 | 11.68 | 7 | 31454 | 929 | 56259677 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Impulse-control disorder | 762.87 | 14 | 174 | 19835 | 1102 | 31676233 |
Gambling disorder | 611.51 | 14 | 152 | 19857 | 1450 | 31675885 |
Hypersexuality | 589.02 | 14 | 144 | 19865 | 1274 | 31676061 |
Hallucination | 450.23 | 14 | 309 | 19700 | 46101 | 31631234 |
Dyskinesia | 341.43 | 14 | 194 | 19815 | 20716 | 31656619 |
On and off phenomenon | 299.17 | 14 | 92 | 19917 | 2018 | 31675317 |
Restless legs syndrome | 288.49 | 14 | 126 | 19883 | 7630 | 31669705 |
Dopamine dysregulation syndrome | 232.86 | 14 | 52 | 19957 | 294 | 31677041 |
Hallucination, visual | 196.34 | 14 | 123 | 19886 | 15671 | 31661664 |
Gambling | 196.07 | 14 | 41 | 19968 | 160 | 31677175 |
Compulsive shopping | 178.11 | 14 | 43 | 19966 | 358 | 31676977 |
Freezing phenomenon | 123.21 | 14 | 42 | 19967 | 1288 | 31676047 |
Stereotypy | 118.59 | 14 | 35 | 19974 | 663 | 31676672 |
Jealous delusion | 110.15 | 14 | 27 | 19982 | 241 | 31677094 |
Obsessive-compulsive disorder | 108.95 | 14 | 56 | 19953 | 4881 | 31672454 |
Needle fatigue | 107.47 | 14 | 33 | 19976 | 719 | 31676616 |
Delusion | 104.65 | 14 | 75 | 19934 | 11922 | 31665413 |
Gait spastic | 101.57 | 14 | 33 | 19976 | 869 | 31676466 |
Relapsing-remitting multiple sclerosis | 100.30 | 14 | 33 | 19976 | 905 | 31676430 |
Paraphilia | 99.20 | 14 | 20 | 19989 | 62 | 31677273 |
Gait disturbance | 91.05 | 14 | 170 | 19839 | 77325 | 31600010 |
Muscle rigidity | 88.92 | 14 | 63 | 19946 | 9834 | 31667501 |
Nocturia | 88.13 | 14 | 61 | 19948 | 9174 | 31668161 |
Libido increased | 87.25 | 14 | 28 | 19981 | 708 | 31676627 |
Sudden onset of sleep | 86.54 | 14 | 24 | 19985 | 360 | 31676975 |
Stoma site erythema | 85.50 | 14 | 27 | 19982 | 647 | 31676688 |
Fall | 84.88 | 14 | 284 | 19725 | 185805 | 31491530 |
Hypertonic bladder | 80.60 | 14 | 33 | 19976 | 1697 | 31675638 |
Monoparesis | 80.43 | 14 | 35 | 19974 | 2096 | 31675239 |
Parkinsonism hyperpyrexia syndrome | 80.37 | 14 | 17 | 19992 | 71 | 31677264 |
Bradykinesia | 77.11 | 14 | 40 | 19969 | 3552 | 31673783 |
Binge eating | 74.56 | 14 | 17 | 19992 | 107 | 31677228 |
Micturition urgency | 74.42 | 14 | 46 | 19963 | 5714 | 31671621 |
Memory impairment | 73.90 | 14 | 105 | 19904 | 38025 | 31639310 |
Insomnia | 72.92 | 14 | 175 | 19834 | 94661 | 31582674 |
Abnormal behaviour | 72.22 | 14 | 82 | 19927 | 23746 | 31653589 |
Psychomotor hyperactivity | 67.75 | 14 | 51 | 19958 | 8736 | 31668599 |
Movement disorder | 65.74 | 14 | 55 | 19954 | 10964 | 31666371 |
Stoma site discharge | 61.33 | 14 | 23 | 19986 | 934 | 31676401 |
Central nervous system lesion | 60.80 | 14 | 41 | 19968 | 5907 | 31671428 |
Muscle spasticity | 60.39 | 14 | 40 | 19969 | 5595 | 31671740 |
Balance disorder | 59.57 | 14 | 94 | 19915 | 37328 | 31640007 |
Hyperkinesia | 58.36 | 14 | 26 | 19983 | 1647 | 31675688 |
Dysarthria | 54.56 | 14 | 83 | 19926 | 31934 | 31645401 |
Agitation | 54.04 | 14 | 111 | 19898 | 54058 | 31623277 |
Impulsive behaviour | 53.77 | 14 | 26 | 19983 | 1987 | 31675348 |
Toxicity to various agents | 53.26 | 14 | 24 | 19985 | 181463 | 31495872 |
Confusional state | 51.63 | 14 | 193 | 19816 | 133141 | 31544194 |
Encephalitis toxic | 51.38 | 14 | 15 | 19994 | 273 | 31677062 |
Aggression | 49.06 | 14 | 86 | 19923 | 37205 | 31640130 |
Compulsive hoarding | 48.50 | 14 | 9 | 20000 | 15 | 31677320 |
Tremor | 48.28 | 14 | 131 | 19878 | 76289 | 31601046 |
Parkinson's disease | 47.84 | 14 | 22 | 19987 | 1501 | 31675834 |
Neuroleptic malignant syndrome | 47.66 | 14 | 56 | 19953 | 16813 | 31660522 |
Ataxia | 47.24 | 14 | 49 | 19960 | 12814 | 31664521 |
Psychotic disorder | 47.07 | 14 | 64 | 19945 | 22229 | 31655106 |
Anxiety | 46.86 | 14 | 145 | 19864 | 90888 | 31586447 |
Delirium | 46.26 | 14 | 89 | 19920 | 41332 | 31636003 |
Stoma site pain | 44.84 | 14 | 16 | 19993 | 563 | 31676772 |
Febrile neutropenia | 44.63 | 14 | 11 | 19998 | 121838 | 31555497 |
Voyeurism | 44.58 | 14 | 7 | 20002 | 0 | 31677335 |
Multiple sclerosis relapse | 44.44 | 14 | 46 | 19963 | 12001 | 31665334 |
Neutropenia | 43.67 | 14 | 17 | 19992 | 140347 | 31536988 |
Mania | 43.11 | 14 | 40 | 19969 | 9137 | 31668198 |
Somnolence | 42.76 | 14 | 149 | 19860 | 99296 | 31578039 |
Device dislocation | 42.04 | 14 | 31 | 19978 | 5145 | 31672190 |
Sleep attacks | 41.70 | 14 | 11 | 19998 | 135 | 31677200 |
Dependence | 41.39 | 14 | 18 | 19991 | 1076 | 31676259 |
Diarrhoea | 41.29 | 14 | 102 | 19907 | 352307 | 31325028 |
Dystonia | 41.29 | 14 | 41 | 19968 | 10184 | 31667151 |
Compulsive sexual behaviour | 40.33 | 14 | 12 | 19997 | 234 | 31677101 |
Pyrexia | 39.58 | 14 | 83 | 19926 | 303757 | 31373578 |
Economic problem | 38.80 | 14 | 18 | 19991 | 1253 | 31676082 |
Hyperphagia | 38.18 | 14 | 18 | 19991 | 1300 | 31676035 |
Acute kidney injury | 37.61 | 14 | 75 | 19934 | 279639 | 31397696 |
Hypomania | 37.13 | 14 | 21 | 19988 | 2214 | 31675121 |
Excessive masturbation | 36.35 | 14 | 9 | 20000 | 84 | 31677251 |
Posture abnormal | 35.93 | 14 | 20 | 19989 | 2044 | 31675291 |
Pollakiuria | 35.70 | 14 | 50 | 19959 | 17852 | 31659483 |
Dizziness | 34.93 | 14 | 230 | 19779 | 198917 | 31478418 |
Restlessness | 33.51 | 14 | 56 | 19953 | 23305 | 31654030 |
Suspiciousness | 33.28 | 14 | 11 | 19998 | 306 | 31677029 |
Dementia | 33.21 | 14 | 40 | 19969 | 12320 | 31665015 |
Delusional disorder, jealous type | 31.84 | 14 | 5 | 20004 | 0 | 31677335 |
Therapeutic product effect variable | 31.63 | 14 | 18 | 19991 | 1920 | 31675415 |
Paranoia | 31.42 | 14 | 36 | 19973 | 10519 | 31666816 |
Akinesia | 31.03 | 14 | 18 | 19991 | 1990 | 31675345 |
Personality change | 30.82 | 14 | 25 | 19984 | 4770 | 31672565 |
Somnambulism | 29.96 | 14 | 20 | 19989 | 2832 | 31674503 |
Depression | 29.89 | 14 | 125 | 19884 | 90690 | 31586645 |
Pancytopenia | 29.86 | 14 | 9 | 20000 | 87307 | 31590028 |
Disturbance in attention | 29.81 | 14 | 52 | 19957 | 22398 | 31654937 |
Bipolar I disorder | 29.52 | 14 | 13 | 19996 | 801 | 31676534 |
Sexually inappropriate behaviour | 29.30 | 14 | 11 | 19998 | 448 | 31676887 |
Reduced facial expression | 29.07 | 14 | 13 | 19996 | 831 | 31676504 |
Platelet count decreased | 28.79 | 14 | 17 | 19992 | 110418 | 31566917 |
Road traffic accident | 28.65 | 14 | 43 | 19966 | 16338 | 31660997 |
Cognitive disorder | 28.36 | 14 | 54 | 19955 | 24869 | 31652466 |
Hypervigilance | 27.91 | 14 | 8 | 20001 | 136 | 31677199 |
Contraindicated product prescribed | 27.88 | 14 | 10 | 19999 | 357 | 31676978 |
Dropped head syndrome | 27.70 | 14 | 8 | 20001 | 140 | 31677195 |
Acute psychosis | 27.62 | 14 | 16 | 19993 | 1765 | 31675570 |
Sleep disorder | 27.45 | 14 | 55 | 19954 | 26293 | 31651042 |
Erectile dysfunction | 27.44 | 14 | 46 | 19963 | 19189 | 31658146 |
Obsessive-compulsive personality disorder | 27.43 | 14 | 8 | 20001 | 145 | 31677190 |
Embedded device | 27.10 | 14 | 9 | 20000 | 254 | 31677081 |
Motor dysfunction | 26.67 | 14 | 26 | 19983 | 6313 | 31671022 |
Hallucination, tactile | 26.43 | 14 | 9 | 20000 | 275 | 31677060 |
Anticholinergic syndrome | 25.92 | 14 | 13 | 19996 | 1075 | 31676260 |
Compulsions | 25.40 | 14 | 8 | 20001 | 190 | 31677145 |
Condition aggravated | 24.93 | 14 | 183 | 19826 | 163826 | 31513509 |
Spontaneous penile erection | 24.82 | 14 | 8 | 20001 | 205 | 31677130 |
Troponin increased | 24.66 | 14 | 31 | 19978 | 9971 | 31667364 |
Parkinsonism | 24.35 | 14 | 27 | 19982 | 7609 | 31669726 |
Human ehrlichiosis | 24.29 | 14 | 8 | 20001 | 220 | 31677115 |
Malignant neoplasm progression | 23.84 | 14 | 10 | 19999 | 78988 | 31598347 |
Stoma site haemorrhage | 23.77 | 14 | 11 | 19998 | 761 | 31676574 |
Dysstasia | 23.59 | 14 | 32 | 19977 | 11086 | 31666249 |
Drug withdrawal syndrome | 23.05 | 14 | 42 | 19967 | 18708 | 31658627 |
Medical device site dryness | 22.74 | 14 | 5 | 20004 | 26 | 31677309 |
Device effect decreased | 22.70 | 14 | 4 | 20005 | 4 | 31677331 |
Intentional medical device removal by patient | 22.68 | 14 | 8 | 20001 | 272 | 31677063 |
Depressive symptom | 22.63 | 14 | 15 | 19994 | 2099 | 31675236 |
Device occlusion | 22.53 | 14 | 23 | 19986 | 5902 | 31671433 |
Stoma site hypergranulation | 22.48 | 14 | 7 | 20002 | 160 | 31677175 |
Bradycardia | 22.46 | 14 | 95 | 19914 | 69232 | 31608103 |
Food interaction | 22.09 | 14 | 11 | 19998 | 896 | 31676439 |
Sleep-related eating disorder | 22.06 | 14 | 8 | 20001 | 295 | 31677040 |
Sleep apnoea syndrome | 21.99 | 14 | 41 | 19968 | 18584 | 31658751 |
Stoma site inflammation | 21.99 | 14 | 9 | 20000 | 462 | 31676873 |
Sepsis | 21.89 | 14 | 39 | 19970 | 151890 | 31525445 |
Verbal abuse | 21.88 | 14 | 7 | 20002 | 175 | 31677160 |
Rapid eye movements sleep abnormal | 21.77 | 14 | 7 | 20002 | 178 | 31677157 |
Inappropriate antidiuretic hormone secretion | 21.51 | 14 | 31 | 19978 | 11356 | 31665979 |
Cardiac dysfunction | 21.03 | 14 | 14 | 19995 | 1973 | 31675362 |
Withdrawal syndrome | 20.83 | 14 | 31 | 19978 | 11686 | 31665649 |
VACTERL syndrome | 20.46 | 14 | 5 | 20004 | 44 | 31677291 |
Abnormal dreams | 19.09 | 14 | 23 | 19986 | 7085 | 31670250 |
Cardiac arrest | 18.93 | 14 | 17 | 19992 | 89045 | 31588290 |
Device issue | 18.88 | 14 | 25 | 19984 | 8459 | 31668876 |
Marital problem | 18.76 | 14 | 5 | 20004 | 64 | 31677271 |
Tension | 18.57 | 14 | 13 | 19996 | 1988 | 31675347 |
Off label use | 18.46 | 14 | 136 | 19873 | 347138 | 31330197 |
White blood cell count decreased | 18.19 | 14 | 17 | 19992 | 87381 | 31589954 |
Stoma site infection | 18.12 | 14 | 9 | 20000 | 729 | 31676606 |
Hyperkalaemia | 18.08 | 14 | 9 | 20000 | 64342 | 31612993 |
Sexual activity increased | 18.00 | 14 | 4 | 20005 | 22 | 31677313 |
Rash | 17.99 | 14 | 66 | 19943 | 201420 | 31475915 |
Gait inability | 17.64 | 14 | 38 | 19971 | 19106 | 31658229 |
Nightmare | 17.27 | 14 | 29 | 19980 | 12108 | 31665227 |
Torticollis | 17.27 | 14 | 10 | 19999 | 1102 | 31676233 |
Disease progression | 17.23 | 14 | 19 | 19990 | 90445 | 31586890 |
Mobility decreased | 17.23 | 14 | 47 | 19962 | 27422 | 31649913 |
Visual impairment | 17.17 | 14 | 51 | 19958 | 31228 | 31646107 |
Anaemia | 17.12 | 14 | 73 | 19936 | 213449 | 31463886 |
Eosinophilic fasciitis | 17.08 | 14 | 5 | 20004 | 92 | 31677243 |
Sopor | 16.97 | 14 | 28 | 19981 | 11524 | 31665811 |
Device alarm issue | 16.94 | 14 | 8 | 20001 | 580 | 31676755 |
Suicidal ideation | 16.89 | 14 | 56 | 19953 | 36350 | 31640985 |
Lung hyperinflation | 16.88 | 14 | 9 | 20000 | 845 | 31676490 |
Interstitial lung disease | 16.64 | 14 | 9 | 20000 | 61394 | 31615941 |
Device kink | 16.53 | 14 | 7 | 20002 | 392 | 31676943 |
Hyperthyroidism | 16.44 | 14 | 25 | 19984 | 9606 | 31667729 |
Device loosening | 16.24 | 14 | 5 | 20004 | 110 | 31677225 |
Therapeutic response unexpected | 16.22 | 14 | 24 | 19985 | 9000 | 31668335 |
Neutrophil count decreased | 15.46 | 14 | 5 | 20004 | 46389 | 31630946 |
Mental impairment | 15.23 | 14 | 24 | 19985 | 9508 | 31667827 |
Excessive exercise | 15.21 | 14 | 3 | 20006 | 8 | 31677327 |
Paedophilia | 15.21 | 14 | 3 | 20006 | 8 | 31677327 |
Rapid eye movement sleep behaviour disorder | 15.06 | 14 | 5 | 20004 | 141 | 31677194 |
Hemivertebra | 14.99 | 14 | 5 | 20004 | 143 | 31677192 |
Pleurothotonus | 14.88 | 14 | 9 | 20000 | 1074 | 31676261 |
IVth nerve paresis | 14.29 | 14 | 3 | 20006 | 12 | 31677323 |
Drug hypersensitivity | 14.10 | 14 | 15 | 19994 | 72584 | 31604751 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Impulse-control disorder | 754.95 | 11.38 | 178 | 39927 | 1501 | 70886838 |
Gambling disorder | 658.80 | 11.38 | 164 | 39941 | 1774 | 70886565 |
Dyskinesia | 559.56 | 11.38 | 326 | 39779 | 40748 | 70847591 |
Hallucination | 448.34 | 11.38 | 360 | 39745 | 75900 | 70812439 |
Restless legs syndrome | 413.67 | 11.38 | 204 | 39901 | 18224 | 70870115 |
On and off phenomenon | 410.41 | 11.38 | 122 | 39983 | 2664 | 70885675 |
Hypersexuality | 407.24 | 11.38 | 107 | 39998 | 1456 | 70886883 |
Hallucination, visual | 297.60 | 11.38 | 193 | 39912 | 29144 | 70859195 |
Compulsive shopping | 279.44 | 11.38 | 69 | 40036 | 719 | 70887620 |
Dopamine dysregulation syndrome | 241.61 | 11.38 | 56 | 40049 | 434 | 70887905 |
Parkinsonism hyperpyrexia syndrome | 212.22 | 11.38 | 44 | 40061 | 187 | 70888152 |
Gambling | 184.46 | 11.38 | 41 | 40064 | 257 | 70888082 |
Freezing phenomenon | 154.51 | 11.38 | 51 | 40054 | 1583 | 70886756 |
Dystonia | 148.57 | 11.38 | 108 | 39997 | 19598 | 70868741 |
Stereotypy | 143.98 | 11.38 | 42 | 40063 | 856 | 70887483 |
Jealous delusion | 142.57 | 11.38 | 33 | 40072 | 254 | 70888085 |
Bradykinesia | 127.74 | 11.38 | 69 | 40036 | 7433 | 70880906 |
Fall | 121.03 | 11.38 | 534 | 39571 | 443562 | 70444777 |
Muscle rigidity | 117.91 | 11.38 | 92 | 40013 | 18558 | 70869781 |
Stoma site discharge | 115.76 | 11.38 | 42 | 40063 | 1737 | 70886602 |
Binge eating | 115.72 | 11.38 | 31 | 40074 | 456 | 70887883 |
Delusion | 115.70 | 11.38 | 92 | 40013 | 19073 | 70869266 |
Stoma site erythema | 110.24 | 11.38 | 38 | 40067 | 1350 | 70886989 |
Obsessive-compulsive disorder | 107.39 | 11.38 | 55 | 40050 | 5315 | 70883024 |
Tremor | 106.81 | 11.38 | 257 | 39848 | 155367 | 70732972 |
Needle fatigue | 101.96 | 11.38 | 31 | 40074 | 732 | 70887607 |
Hyperkinesia | 99.93 | 11.38 | 42 | 40063 | 2581 | 70885758 |
Neuroleptic malignant syndrome | 97.03 | 11.38 | 95 | 40010 | 25912 | 70862427 |
Psychotic disorder | 95.23 | 11.38 | 112 | 39993 | 37589 | 70850750 |
Gait spastic | 92.31 | 11.38 | 31 | 40074 | 1016 | 70887323 |
Compulsive hoarding | 91.45 | 11.38 | 18 | 40087 | 55 | 70888284 |
Stoma site pain | 91.23 | 11.38 | 32 | 40073 | 1198 | 70887141 |
Sudden onset of sleep | 90.35 | 11.38 | 27 | 40078 | 600 | 70887739 |
Gait disturbance | 85.23 | 11.38 | 264 | 39841 | 184842 | 70703497 |
Relapsing-remitting multiple sclerosis | 84.09 | 11.38 | 31 | 40074 | 1342 | 70886997 |
Pleurothotonus | 83.88 | 11.38 | 36 | 40069 | 2330 | 70886009 |
Abnormal behaviour | 79.30 | 11.38 | 98 | 40007 | 34611 | 70853728 |
Insomnia | 75.93 | 11.38 | 283 | 39822 | 217523 | 70670816 |
Acute psychosis | 72.25 | 11.38 | 38 | 40067 | 3878 | 70884461 |
Febrile neutropenia | 70.03 | 11.38 | 15 | 40090 | 204303 | 70684036 |
Akinesia | 68.26 | 11.38 | 34 | 40071 | 3097 | 70885242 |
Nocturia | 68.18 | 11.38 | 56 | 40049 | 12148 | 70876191 |
Therapeutic response shortened | 67.76 | 11.38 | 57 | 40048 | 12781 | 70875558 |
Torticollis | 66.62 | 11.38 | 30 | 40075 | 2179 | 70886160 |
Delirium | 65.49 | 11.38 | 136 | 39969 | 74478 | 70813861 |
Monoparesis | 64.41 | 11.38 | 33 | 40072 | 3191 | 70885148 |
Movement disorder | 63.12 | 11.38 | 73 | 40032 | 24056 | 70864283 |
Paraphilia | 62.94 | 11.38 | 13 | 40092 | 54 | 70888285 |
Camptocormia | 61.96 | 11.38 | 19 | 40086 | 462 | 70887877 |
Orthostatic hypotension | 61.08 | 11.38 | 107 | 39998 | 51636 | 70836703 |
Sleep attacks | 59.67 | 11.38 | 15 | 40090 | 169 | 70888170 |
Hypertonic bladder | 59.44 | 11.38 | 33 | 40072 | 3750 | 70884589 |
Neutropenia | 59.30 | 11.38 | 36 | 40069 | 257120 | 70631219 |
Anxiety | 56.10 | 11.38 | 260 | 39845 | 220070 | 70668269 |
Toxicity to various agents | 55.84 | 11.38 | 81 | 40024 | 382091 | 70506248 |
Psychomotor hyperactivity | 55.01 | 11.38 | 55 | 40050 | 15378 | 70872961 |
Impulsive behaviour | 54.47 | 11.38 | 28 | 40077 | 2726 | 70885613 |
Parkinson's disease | 52.94 | 11.38 | 24 | 40081 | 1771 | 70886568 |
Parkinsonism | 51.67 | 11.38 | 53 | 40052 | 15272 | 70873067 |
Micturition urgency | 51.16 | 11.38 | 46 | 40059 | 11268 | 70877071 |
Therapeutic product effect variable | 50.86 | 11.38 | 23 | 40082 | 1687 | 70886652 |
Dropped head syndrome | 50.37 | 11.38 | 14 | 40091 | 238 | 70888101 |
Drug withdrawal syndrome | 49.93 | 11.38 | 76 | 40029 | 32639 | 70855700 |
Encephalitis toxic | 48.28 | 11.38 | 14 | 40091 | 279 | 70888060 |
Posture abnormal | 47.47 | 11.38 | 28 | 40077 | 3568 | 70884771 |
Memory impairment | 47.19 | 11.38 | 137 | 39968 | 92504 | 70795835 |
Somnolence | 46.71 | 11.38 | 243 | 39862 | 215363 | 70672976 |
Suspiciousness | 45.54 | 11.38 | 16 | 40089 | 602 | 70887737 |
Cognitive disorder | 45.39 | 11.38 | 104 | 40001 | 60852 | 70827487 |
Central nervous system lesion | 43.68 | 11.38 | 44 | 40061 | 12409 | 70875930 |
Libido increased | 42.84 | 11.38 | 21 | 40084 | 1848 | 70886491 |
Balance disorder | 42.78 | 11.38 | 130 | 39975 | 89998 | 70798341 |
Restlessness | 42.00 | 11.38 | 81 | 40024 | 42047 | 70846292 |
Pancytopenia | 41.05 | 11.38 | 17 | 40088 | 151090 | 70737249 |
Agitation | 40.92 | 11.38 | 131 | 39974 | 93244 | 70795095 |
Multiple sclerosis relapse | 40.81 | 11.38 | 81 | 40024 | 42936 | 70845403 |
Aggression | 39.83 | 11.38 | 86 | 40019 | 48360 | 70839979 |
Pyrexia | 39.38 | 11.38 | 193 | 39912 | 606759 | 70281580 |
Voyeurism | 38.87 | 11.38 | 6 | 40099 | 0 | 70888339 |
Rash | 38.78 | 11.38 | 153 | 39952 | 510409 | 70377930 |
Diarrhoea | 38.67 | 11.38 | 272 | 39833 | 783069 | 70105270 |
Malignant neoplasm progression | 37.71 | 11.38 | 11 | 40094 | 121728 | 70766611 |
Economic problem | 36.76 | 11.38 | 20 | 40085 | 2184 | 70886155 |
Stoma site infection | 36.74 | 11.38 | 17 | 40088 | 1315 | 70887024 |
Abnormal dreams | 36.35 | 11.38 | 37 | 40068 | 10566 | 70877773 |
Confusional state | 36.27 | 11.38 | 280 | 39825 | 284118 | 70604221 |
Rheumatoid arthritis | 35.96 | 11.38 | 69 | 40036 | 291736 | 70596603 |
Hyperphagia | 35.49 | 11.38 | 20 | 40085 | 2339 | 70886000 |
Drug dispensed to wrong patient | 35.21 | 11.38 | 13 | 40092 | 565 | 70887774 |
Dizziness | 34.74 | 11.38 | 408 | 39697 | 463733 | 70424606 |
Withdrawal syndrome | 34.04 | 11.38 | 55 | 40050 | 24849 | 70863490 |
Pericarditis | 33.99 | 11.38 | 4 | 40101 | 84701 | 70803638 |
Mania | 33.73 | 11.38 | 45 | 40060 | 17129 | 70871210 |
Depressive symptom | 33.70 | 11.38 | 26 | 40079 | 5155 | 70883184 |
Excessive masturbation | 33.45 | 11.38 | 8 | 40097 | 72 | 70888267 |
Compulsions | 33.09 | 11.38 | 11 | 40094 | 349 | 70887990 |
Depressed mood | 32.88 | 11.38 | 75 | 40030 | 43745 | 70844594 |
Reduced facial expression | 32.86 | 11.38 | 19 | 40086 | 2333 | 70886006 |
Dementia | 32.78 | 11.38 | 51 | 40054 | 22314 | 70866025 |
Hand deformity | 32.52 | 11.38 | 5 | 40100 | 86477 | 70801862 |
Acute kidney injury | 32.47 | 11.38 | 148 | 39957 | 474476 | 70413863 |
Delusional disorder, jealous type | 32.39 | 11.38 | 5 | 40100 | 0 | 70888339 |
Erectile dysfunction | 32.11 | 11.38 | 39 | 40066 | 13523 | 70874816 |
Nightmare | 31.75 | 11.38 | 50 | 40055 | 22106 | 70866233 |
Medication error | 31.75 | 11.38 | 87 | 40018 | 56825 | 70831514 |
Total lung capacity decreased | 30.46 | 11.38 | 17 | 40088 | 1952 | 70886387 |
Troponin increased | 30.31 | 11.38 | 42 | 40063 | 16572 | 70871767 |
Multiple drug therapy | 29.91 | 11.38 | 20 | 40085 | 3172 | 70885167 |
Blood pressure inadequately controlled | 29.86 | 11.38 | 25 | 40080 | 5567 | 70882772 |
Dysarthria | 29.67 | 11.38 | 90 | 40015 | 62223 | 70826116 |
Stomatitis | 29.58 | 11.38 | 18 | 40087 | 128493 | 70759846 |
Condition aggravated | 29.40 | 11.38 | 370 | 39735 | 427265 | 70461074 |
Oedema peripheral | 29.30 | 11.38 | 225 | 39880 | 227866 | 70660473 |
Ataxia | 28.68 | 11.38 | 49 | 40056 | 23168 | 70865171 |
Glossodynia | 28.32 | 11.38 | 7 | 40098 | 86480 | 70801859 |
Maternal exposure during pregnancy | 28.21 | 11.38 | 15 | 40090 | 115330 | 70773009 |
Bronchopulmonary aspergillosis allergic | 27.76 | 11.38 | 16 | 40089 | 1953 | 70886386 |
Inappropriate antidiuretic hormone secretion | 27.29 | 11.38 | 48 | 40057 | 23228 | 70865111 |
Malignant polyp | 27.29 | 11.38 | 8 | 40097 | 166 | 70888173 |
Pollakiuria | 27.04 | 11.38 | 59 | 40046 | 33402 | 70854937 |
Snoring | 26.34 | 11.38 | 22 | 40083 | 4882 | 70883457 |
Prescribed underdose | 26.24 | 11.38 | 45 | 40060 | 21340 | 70866999 |
Sexually inappropriate behaviour | 25.66 | 11.38 | 10 | 40095 | 505 | 70887834 |
Contraindicated product administered | 25.62 | 11.38 | 23 | 40082 | 134589 | 70753750 |
Dependence | 25.46 | 11.38 | 16 | 40089 | 2284 | 70886055 |
Discomfort | 25.36 | 11.38 | 14 | 40091 | 105422 | 70782917 |
Marital problem | 25.29 | 11.38 | 8 | 40097 | 216 | 70888123 |
Personality change | 25.17 | 11.38 | 28 | 40077 | 8842 | 70879497 |
Obsessive-compulsive personality disorder | 24.97 | 11.38 | 7 | 40098 | 123 | 70888216 |
Platelet count decreased | 24.80 | 11.38 | 39 | 40066 | 178183 | 70710156 |
Sleep apnoea syndrome | 24.55 | 11.38 | 56 | 40049 | 32657 | 70855682 |
Product residue present | 24.33 | 11.38 | 18 | 40087 | 3352 | 70884987 |
Compulsive sexual behaviour | 24.18 | 11.38 | 8 | 40097 | 250 | 70888089 |
Kleptomania | 23.62 | 11.38 | 5 | 40100 | 24 | 70888315 |
Muscle spasticity | 23.60 | 11.38 | 41 | 40064 | 19648 | 70868691 |
Dysstasia | 23.38 | 11.38 | 47 | 40058 | 25132 | 70863207 |
Device dislocation | 23.32 | 11.38 | 44 | 40061 | 22463 | 70865876 |
Depression | 23.21 | 11.38 | 192 | 39913 | 198782 | 70689557 |
Diabetes mellitus inadequate control | 23.13 | 11.38 | 44 | 40061 | 22601 | 70865738 |
Bipolar I disorder | 22.91 | 11.38 | 14 | 40091 | 1903 | 70886436 |
Pituitary haemorrhage | 22.87 | 11.38 | 8 | 40097 | 297 | 70888042 |
Disturbance in attention | 22.37 | 11.38 | 64 | 40041 | 42830 | 70845509 |
Cardiac arrest | 22.21 | 11.38 | 35 | 40070 | 159799 | 70728540 |
Hallucination, tactile | 21.94 | 11.38 | 9 | 40096 | 520 | 70887819 |
Therapeutic response unexpected | 21.89 | 11.38 | 38 | 40067 | 18193 | 70870146 |
Vaccination site bruising | 21.87 | 11.38 | 4 | 40101 | 7 | 70888332 |
Chorea | 21.87 | 11.38 | 14 | 40091 | 2064 | 70886275 |
Pulmonary fibrosis | 21.73 | 11.38 | 55 | 40050 | 34255 | 70854084 |
Vaccination site pruritus | 21.52 | 11.38 | 4 | 40101 | 8 | 70888331 |
Vaccination site oedema | 21.52 | 11.38 | 4 | 40101 | 8 | 70888331 |
Off label use | 21.38 | 11.38 | 294 | 39811 | 742766 | 70145573 |
Orthostatic intolerance | 21.36 | 11.38 | 13 | 40092 | 1754 | 70886585 |
Mucosal inflammation | 21.25 | 11.38 | 6 | 40099 | 67844 | 70820495 |
Product prescribing error | 21.18 | 11.38 | 59 | 40046 | 38893 | 70849446 |
Device occlusion | 21.17 | 11.38 | 28 | 40077 | 10567 | 70877772 |
Hyperventilation | 20.94 | 11.38 | 23 | 40082 | 7163 | 70881176 |
Spontaneous penile erection | 20.67 | 11.38 | 6 | 40099 | 120 | 70888219 |
Lung opacity | 20.66 | 11.38 | 17 | 40088 | 3696 | 70884643 |
Stoma site inflammation | 20.63 | 11.38 | 9 | 40096 | 606 | 70887733 |
Suicidal ideation | 20.61 | 11.38 | 86 | 40019 | 69510 | 70818829 |
Stoma site hypergranulation | 20.58 | 11.38 | 8 | 40097 | 401 | 70887938 |
Blister | 20.58 | 11.38 | 16 | 40089 | 100510 | 70787829 |
Human ehrlichiosis | 20.47 | 11.38 | 8 | 40097 | 407 | 70887932 |
Autonomic nervous system imbalance | 20.33 | 11.38 | 18 | 40087 | 4321 | 70884018 |
Alopecia | 20.27 | 11.38 | 52 | 40053 | 198438 | 70689901 |
Synovitis | 20.23 | 11.38 | 26 | 40079 | 129202 | 70759137 |
Rapid eye movements sleep abnormal | 20.22 | 11.38 | 7 | 40098 | 252 | 70888087 |
Drug intolerance | 20.19 | 11.38 | 63 | 40042 | 225624 | 70662715 |
Verbal abuse | 20.09 | 11.38 | 7 | 40098 | 257 | 70888082 |
Food interaction | 19.98 | 11.38 | 12 | 40093 | 1581 | 70886758 |
Hypervigilance | 19.52 | 11.38 | 8 | 40097 | 461 | 70887878 |
Paedophilia | 19.44 | 11.38 | 3 | 40102 | 0 | 70888339 |
Paranoia | 19.43 | 11.38 | 35 | 40070 | 17253 | 70871086 |
Disease progression | 19.32 | 11.38 | 37 | 40068 | 156635 | 70731704 |
Vestibular migraine | 19.30 | 11.38 | 6 | 40099 | 153 | 70888186 |
Thrombocytopenia | 19.18 | 11.38 | 70 | 40035 | 239040 | 70649299 |
Duodenal ulcer perforation | 19.11 | 11.38 | 3 | 40102 | 51109 | 70837230 |
Irritable bowel syndrome | 18.98 | 11.38 | 3 | 40102 | 50847 | 70837492 |
Device kink | 18.91 | 11.38 | 12 | 40093 | 1743 | 70886596 |
Urticaria | 18.83 | 11.38 | 40 | 40065 | 163009 | 70725330 |
Hypomania | 18.68 | 11.38 | 20 | 40085 | 6052 | 70882287 |
Hypersensitivity | 18.61 | 11.38 | 67 | 40038 | 229745 | 70658594 |
Intentional medical device removal by patient | 18.06 | 11.38 | 7 | 40098 | 348 | 70887991 |
Bone marrow failure | 18.05 | 11.38 | 3 | 40102 | 49007 | 70839332 |
Product substitution issue | 17.72 | 11.38 | 35 | 40070 | 18478 | 70869861 |
Female orgasmic disorder | 17.49 | 11.38 | 4 | 40101 | 29 | 70888310 |
White blood cell count decreased | 17.05 | 11.38 | 45 | 40060 | 170096 | 70718243 |
Blood calcium increased | 16.80 | 11.38 | 23 | 40082 | 8970 | 70879369 |
Device issue | 16.79 | 11.38 | 40 | 40065 | 23985 | 70864354 |
Stoma site haemorrhage | 16.72 | 11.38 | 11 | 40094 | 1698 | 70886641 |
Drug reaction with eosinophilia and systemic symptoms | 16.62 | 11.38 | 6 | 40099 | 58007 | 70830332 |
Hepatocellular injury | 16.58 | 11.38 | 3 | 40102 | 46088 | 70842251 |
Nasopharyngitis | 16.56 | 11.38 | 67 | 40038 | 222139 | 70666200 |
Fibroma | 16.37 | 11.38 | 8 | 40097 | 699 | 70887640 |
Obsessive thoughts | 16.12 | 11.38 | 9 | 40096 | 1034 | 70887305 |
Joint swelling | 16.08 | 11.38 | 81 | 40024 | 253130 | 70635209 |
Conjunctival discolouration | 16.06 | 11.38 | 5 | 40100 | 128 | 70888211 |
Serum serotonin increased | 15.97 | 11.38 | 6 | 40099 | 274 | 70888065 |
Contraindicated product prescribed | 15.88 | 11.38 | 10 | 40095 | 1433 | 70886906 |
Abdominal discomfort | 15.82 | 11.38 | 65 | 40040 | 214593 | 70673746 |
Delusion of replacement | 15.31 | 11.38 | 5 | 40100 | 150 | 70888189 |
Exercise tolerance decreased | 15.27 | 11.38 | 21 | 40084 | 8227 | 70880112 |
Anticholinergic syndrome | 15.25 | 11.38 | 13 | 40092 | 2967 | 70885372 |
Stoma site extravasation | 15.12 | 11.38 | 6 | 40099 | 318 | 70888021 |
Vaccination site erythema | 15.11 | 11.38 | 4 | 40101 | 56 | 70888283 |
Stoma site candida | 15.04 | 11.38 | 3 | 40102 | 10 | 70888329 |
Parkinsonian gait | 14.86 | 11.38 | 8 | 40097 | 856 | 70887483 |
Ascites | 14.80 | 11.38 | 10 | 40095 | 67537 | 70820802 |
Orgasm abnormal | 14.63 | 11.38 | 5 | 40100 | 173 | 70888166 |
Speech disorder | 14.59 | 11.38 | 62 | 40043 | 50518 | 70837821 |
Swelling | 14.59 | 11.38 | 56 | 40049 | 188483 | 70699856 |
Sleep disorder | 14.58 | 11.38 | 78 | 40027 | 69794 | 70818545 |
Choking | 14.54 | 11.38 | 24 | 40081 | 11036 | 70877303 |
Interstitial lung disease | 14.47 | 11.38 | 23 | 40082 | 104662 | 70783677 |
Device connection issue | 14.46 | 11.38 | 8 | 40097 | 903 | 70887436 |
Neutrophil count decreased | 13.93 | 11.38 | 16 | 40089 | 83540 | 70804799 |
Somnambulism | 13.90 | 11.38 | 16 | 40089 | 5244 | 70883095 |
Feeling abnormal | 13.83 | 11.38 | 132 | 39973 | 142187 | 70746152 |
Drug tolerance decreased | 13.82 | 11.38 | 22 | 40083 | 9811 | 70878528 |
Hiccups | 13.77 | 11.38 | 21 | 40084 | 9031 | 70879308 |
Coronary artery dissection | 13.73 | 11.38 | 8 | 40097 | 996 | 70887343 |
Amnesia | 13.57 | 11.38 | 62 | 40043 | 52093 | 70836246 |
Ill-defined disorder | 13.55 | 11.38 | 7 | 40098 | 54734 | 70833605 |
Euphoric mood | 13.45 | 11.38 | 18 | 40087 | 6871 | 70881468 |
Sleep-related eating disorder | 13.42 | 11.38 | 7 | 40098 | 702 | 70887637 |
Plasma cell myeloma | 13.35 | 11.38 | 13 | 40092 | 73188 | 70815151 |
Cardiac dysfunction | 13.34 | 11.38 | 13 | 40092 | 3524 | 70884815 |
Treatment failure | 13.05 | 11.38 | 40 | 40065 | 144102 | 70744237 |
Micturition disorder | 12.92 | 11.38 | 13 | 40092 | 3662 | 70884677 |
Motor dysfunction | 12.86 | 11.38 | 25 | 40080 | 13045 | 70875294 |
Anisomastia | 12.86 | 11.38 | 3 | 40102 | 24 | 70888315 |
Hypersomnia | 12.85 | 11.38 | 33 | 40072 | 20731 | 70867608 |
Muscle injury | 12.83 | 11.38 | 3 | 40102 | 38491 | 70849848 |
Bradycardia | 12.82 | 11.38 | 117 | 39988 | 124498 | 70763841 |
Stoma site irritation | 12.80 | 11.38 | 5 | 40100 | 254 | 70888085 |
Heat stroke | 12.77 | 11.38 | 9 | 40096 | 1554 | 70886785 |
Middle insomnia | 12.77 | 11.38 | 26 | 40079 | 14027 | 70874312 |
Sputum discoloured | 12.76 | 11.38 | 31 | 40074 | 18820 | 70869519 |
Sexual activity increased | 12.75 | 11.38 | 3 | 40102 | 25 | 70888314 |
Drug resistance | 12.68 | 11.38 | 3 | 40102 | 38187 | 70850152 |
Eosinophilic fasciitis | 12.54 | 11.38 | 5 | 40100 | 268 | 70888071 |
Excessive exercise | 12.54 | 11.38 | 3 | 40102 | 27 | 70888312 |
Inhibitory drug interaction | 12.53 | 11.38 | 13 | 40092 | 3794 | 70884545 |
Vaccination site pain | 12.34 | 11.38 | 4 | 40101 | 117 | 70888222 |
Meningorrhagia | 12.22 | 11.38 | 5 | 40100 | 287 | 70888052 |
Deep vein thrombosis | 12.19 | 11.38 | 28 | 40077 | 111014 | 70777325 |
Liver injury | 12.18 | 11.38 | 4 | 40101 | 41031 | 70847308 |
Bladder sphincter atony | 12.03 | 11.38 | 4 | 40101 | 127 | 70888212 |
Lung hyperinflation | 11.99 | 11.38 | 9 | 40096 | 1712 | 70886627 |
Apathy | 11.99 | 11.38 | 23 | 40082 | 11885 | 70876454 |
Sepsis | 11.95 | 11.38 | 85 | 40020 | 244460 | 70643879 |
Granuloma skin | 11.94 | 11.38 | 18 | 40087 | 7664 | 70880675 |
Irritability | 11.92 | 11.38 | 48 | 40057 | 38177 | 70850162 |
Aspiration | 11.89 | 11.38 | 29 | 40076 | 17646 | 70870693 |
Keloid scar | 11.86 | 11.38 | 4 | 40101 | 133 | 70888206 |
Blood creatine phosphokinase increased | 11.85 | 11.38 | 67 | 40038 | 61196 | 70827143 |
Agranulocytosis | 11.83 | 11.38 | 4 | 40101 | 40294 | 70848045 |
Underdose | 11.77 | 11.38 | 40 | 40065 | 29343 | 70858996 |
Metabolic acidosis | 11.59 | 11.38 | 15 | 40090 | 74331 | 70814008 |
Exposure during pregnancy | 11.44 | 11.38 | 20 | 40085 | 87697 | 70800642 |
Infection | 11.44 | 11.38 | 71 | 40034 | 210714 | 70677625 |
None
Source | Code | Description |
---|---|---|
ATC | N04BC05 | NERVOUS SYSTEM ANTI-PARKINSON DRUGS DOPAMINERGIC AGENTS Dopamine agonists |
FDA MoA | N0000000117 | Dopamine Agonists |
MeSH PA | D018726 | Anti-Dyskinesia Agents |
MeSH PA | D000975 | Antioxidants |
MeSH PA | D000978 | Antiparkinson Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D015259 | Dopamine Agents |
MeSH PA | D018491 | Dopamine Agonists |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D020011 | Protective Agents |
CHEBI has role | CHEBI:48407 | antiparkinson agent |
CHEBI has role | CHEBI:48578 | free radical scavengers |
CHEBI has role | CHEBI:51065 | Dopamine receptor agonist |
CHEBI has role | CHEBI:66956 | antidyskinetic agent |
FDA EPC | N0000175768 | Nonergot Dopamine Agonist |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Restless legs | indication | 32914008 | DOID:0050425 |
Parkinson's disease | indication | 49049000 | DOID:14330 |
Fibromyalgia | off-label use | 203082005 | DOID:631 |
Hallucinations | contraindication | 7011001 | |
Dyskinesia | contraindication | 9748009 | |
Orthostatic hypotension | contraindication | 28651003 | |
Narcolepsy | contraindication | 60380001 | DOID:8986 |
Psychotic disorder | contraindication | 69322001 | |
Sleep apnea | contraindication | 73430006 | DOID:0050847 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Drowsy | contraindication | 271782001 | |
Malignant melanoma | contraindication | 372244006 | |
Breastfeeding (mother) | contraindication | 413712001 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.57 | Basic |
pKa2 | 5.18 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
0.375MG | MIRAPEX ER | BOEHRINGER INGELHEIM | N022421 | Feb. 19, 2010 | RX | TABLET, EXTENDED RELEASE | ORAL | 8679533 | Sept. 8, 2029 | TREATMENT OF PARKINSONS DISEASE |
0.75MG | MIRAPEX ER | BOEHRINGER INGELHEIM | N022421 | Feb. 19, 2010 | RX | TABLET, EXTENDED RELEASE | ORAL | 8679533 | Sept. 8, 2029 | TREATMENT OF PARKINSONS DISEASE |
1.5MG | MIRAPEX ER | BOEHRINGER INGELHEIM | N022421 | Feb. 19, 2010 | RX | TABLET, EXTENDED RELEASE | ORAL | 8679533 | Sept. 8, 2029 | TREATMENT OF PARKINSONS DISEASE |
2.25MG | MIRAPEX ER | BOEHRINGER INGELHEIM | N022421 | June 17, 2011 | RX | TABLET, EXTENDED RELEASE | ORAL | 8679533 | Sept. 8, 2029 | TREATMENT OF PARKINSONS DISEASE |
3.75MG | MIRAPEX ER | BOEHRINGER INGELHEIM | N022421 | June 17, 2011 | RX | TABLET, EXTENDED RELEASE | ORAL | 8679533 | Sept. 8, 2029 | TREATMENT OF PARKINSONS DISEASE |
3MG | MIRAPEX ER | BOEHRINGER INGELHEIM | N022421 | Feb. 19, 2010 | RX | TABLET, EXTENDED RELEASE | ORAL | 8679533 | Sept. 8, 2029 | TREATMENT OF PARKINSONS DISEASE |
4.5MG | MIRAPEX ER | BOEHRINGER INGELHEIM | N022421 | Feb. 19, 2010 | RX | TABLET, EXTENDED RELEASE | ORAL | 8679533 | Sept. 8, 2029 | TREATMENT OF PARKINSONS DISEASE |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
D(2) dopamine receptor | GPCR | AGONIST | EC50 | 6.60 | WOMBAT-PK | CHEMBL | |||
Alpha-2A adrenergic receptor | GPCR | Ki | 7.12 | PDSP | |||||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 6.16 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 2A | GPCR | EC50 | 5.93 | CHEMBL | |||||
5-hydroxytryptamine receptor 7 | GPCR | Ki | 5.93 | PDSP | |||||
Alpha-2B adrenergic receptor | GPCR | Ki | 6.20 | WOMBAT-PK | |||||
D(3) dopamine receptor | GPCR | AGONIST | EC50 | 8.67 | WOMBAT-PK | ||||
Histamine H2 receptor | GPCR | Ki | 5.57 | PDSP | |||||
5-hydroxytryptamine receptor 1B | GPCR | Ki | 5.46 | PDSP | |||||
5-hydroxytryptamine receptor 1D | GPCR | Ki | 5.78 | PDSP | |||||
Alpha-2C adrenergic receptor | GPCR | Ki | 7.28 | PDSP | |||||
D(4) dopamine receptor | GPCR | AGONIST | Ki | 9.31 | CHEMBL | ||||
Beta-2 adrenergic receptor | GPCR | Ki | 4 | CHEMBL | |||||
D(2) dopamine receptor | GPCR | Ki | 8.51 | CHEMBL | |||||
D(2) dopamine receptor | GPCR | Kd | 8.80 | CHEMBL | |||||
D(3) dopamine receptor | GPCR | Ki | 9.35 | CHEMBL |
ID | Source |
---|---|
4024071 | VUID |
N0000022076 | NUI |
D00559 | KEGG_DRUG |
191217-81-9 | SECONDARY_CAS_RN |
4021042 | VANDF |
4024071 | VANDF |
C0074710 | UMLSCUI |
CHEBI:8356 | CHEBI |
G6L | PDB_CHEM_ID |
CHEMBL301265 | ChEMBL_ID |
DB00413 | DRUGBANK_ID |
CHEMBL3182733 | ChEMBL_ID |
CHEMBL542257 | ChEMBL_ID |
D000077487 | MESH_DESCRIPTOR_UI |
119570 | PUBCHEM_CID |
6227 | INN_ID |
953 | IUPHAR_LIGAND_ID |
83619PEU5T | UNII |
236747 | RXNORM |
169631 | MMSL |
23370 | MMSL |
5340 | MMSL |
d04145 | MMSL |
006721 | NDDF |
006722 | NDDF |
108471007 | SNOMEDCT_US |
386852009 | SNOMEDCT_US |
412282004 | SNOMEDCT_US |
725650009 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Mirapex ER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0109 | TABLET, EXTENDED RELEASE | 0.38 mg | ORAL | NDA | 32 sections |
Mirapex ER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0109 | TABLET, EXTENDED RELEASE | 0.38 mg | ORAL | NDA | 32 sections |
Mirapex ER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0113 | TABLET, EXTENDED RELEASE | 1.50 mg | ORAL | NDA | 32 sections |
Mirapex ER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0113 | TABLET, EXTENDED RELEASE | 1.50 mg | ORAL | NDA | 32 sections |
Mirapex ER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0115 | TABLET, EXTENDED RELEASE | 3 mg | ORAL | NDA | 32 sections |
Mirapex ER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0115 | TABLET, EXTENDED RELEASE | 3 mg | ORAL | NDA | 32 sections |
Mirapex ER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0116 | TABLET, EXTENDED RELEASE | 4.50 mg | ORAL | NDA | 32 sections |
Mirapex ER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0116 | TABLET, EXTENDED RELEASE | 4.50 mg | ORAL | NDA | 32 sections |
Mirapex ER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0285 | TABLET, EXTENDED RELEASE | 0.75 mg | ORAL | NDA | 32 sections |
Mirapex ER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0285 | TABLET, EXTENDED RELEASE | 0.75 mg | ORAL | NDA | 32 sections |
Mirapex ER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0286 | TABLET, EXTENDED RELEASE | 2.25 mg | ORAL | NDA | 32 sections |
Mirapex ER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0286 | TABLET, EXTENDED RELEASE | 2.25 mg | ORAL | NDA | 32 sections |
Mirapex ER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0287 | TABLET, EXTENDED RELEASE | 3.75 mg | ORAL | NDA | 32 sections |
Mirapex ER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0287 | TABLET, EXTENDED RELEASE | 3.75 mg | ORAL | NDA | 32 sections |
Pramipexole Dihydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7597 | TABLET | 1 mg | ORAL | ANDA | 28 sections |
Pramipexole Dihydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6704 | TABLET | 0.25 mg | ORAL | ANDA | 20 sections |
Pramipexole Dihydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6704 | TABLET | 0.25 mg | ORAL | ANDA | 20 sections |
Pramipexole DihydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-251 | TABLET, EXTENDED RELEASE | 0.38 mg | ORAL | ANDA | 28 sections |
Pramipexole DihydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-251 | TABLET, EXTENDED RELEASE | 0.38 mg | ORAL | ANDA | 28 sections |
Pramipexole DihydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-252 | TABLET, EXTENDED RELEASE | 0.75 mg | ORAL | ANDA | 28 sections |
Pramipexole DihydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-252 | TABLET, EXTENDED RELEASE | 0.75 mg | ORAL | ANDA | 28 sections |
Pramipexole DihydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-253 | TABLET, EXTENDED RELEASE | 1.50 mg | ORAL | ANDA | 28 sections |
Pramipexole DihydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-253 | TABLET, EXTENDED RELEASE | 1.50 mg | ORAL | ANDA | 28 sections |
Pramipexole DihydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-254 | TABLET, EXTENDED RELEASE | 3 mg | ORAL | ANDA | 28 sections |
Pramipexole DihydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-254 | TABLET, EXTENDED RELEASE | 3 mg | ORAL | ANDA | 28 sections |
Pramipexole DihydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-255 | TABLET, EXTENDED RELEASE | 4.50 mg | ORAL | ANDA | 28 sections |
Pramipexole DihydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-255 | TABLET, EXTENDED RELEASE | 4.50 mg | ORAL | ANDA | 28 sections |
Pramipexole DihydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-305 | TABLET, EXTENDED RELEASE | 2.25 mg | ORAL | ANDA | 28 sections |
Pramipexole DihydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-305 | TABLET, EXTENDED RELEASE | 2.25 mg | ORAL | ANDA | 28 sections |
Pramipexole DihydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-306 | TABLET, EXTENDED RELEASE | 3.75 mg | ORAL | ANDA | 28 sections |