Stem definition | Drug id | CAS RN |
---|---|---|
2233 | 104632-26-0 |
Dose | Unit | Route |
---|---|---|
2.50 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.20 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 90 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.30 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 93 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 7 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 7.20 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.85 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 12.40 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
July 1, 1997 | FDA | BOEHRINGER INGELHEIM |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Gambling disorder | 419.43 | 11.47 | 104 | 28872 | 1090 | 50575058 |
Dyskinesia | 360.85 | 11.47 | 215 | 28761 | 27646 | 50548502 |
Impulse-control disorder | 315.88 | 11.47 | 74 | 28902 | 596 | 50575552 |
Compulsive shopping | 279.86 | 11.47 | 68 | 28908 | 650 | 50575498 |
On and off phenomenon | 252.12 | 11.47 | 72 | 28904 | 1340 | 50574808 |
Hallucination | 225.82 | 11.47 | 198 | 28778 | 46459 | 50529689 |
Hallucination, visual | 161.82 | 11.47 | 107 | 28869 | 16475 | 50559673 |
Gambling | 154.10 | 11.47 | 34 | 28942 | 202 | 50575946 |
Parkinsonism hyperpyrexia syndrome | 131 | 11.47 | 27 | 28949 | 109 | 50576039 |
Restless legs syndrome | 123.14 | 11.47 | 89 | 28887 | 15808 | 50560340 |
Hypersexuality | 112.73 | 11.47 | 30 | 28946 | 424 | 50575724 |
Tremor | 111.77 | 11.47 | 220 | 28756 | 114683 | 50461465 |
Dystonia | 111.64 | 11.47 | 75 | 28901 | 11851 | 50564297 |
Freezing phenomenon | 96.87 | 11.47 | 32 | 28944 | 983 | 50575165 |
Pleurothotonus | 92.87 | 11.47 | 33 | 28943 | 1268 | 50574880 |
Obsessive-compulsive disorder | 92.79 | 11.47 | 43 | 28933 | 3297 | 50572851 |
Bradykinesia | 91.94 | 11.47 | 45 | 28931 | 3898 | 50572250 |
Sudden onset of sleep | 89.93 | 11.47 | 26 | 28950 | 506 | 50575642 |
Stoma site discharge | 89.72 | 11.47 | 32 | 28944 | 1243 | 50574905 |
Stoma site erythema | 88.69 | 11.47 | 29 | 28947 | 862 | 50575286 |
Muscle rigidity | 85.32 | 11.47 | 59 | 28917 | 9770 | 50566378 |
Stereotypy | 84.30 | 11.47 | 23 | 28953 | 359 | 50575789 |
Binge eating | 74.28 | 11.47 | 21 | 28955 | 376 | 50575772 |
Stoma site pain | 71.39 | 11.47 | 24 | 28952 | 779 | 50575369 |
Camptocormia | 70.53 | 11.47 | 19 | 28957 | 282 | 50575866 |
Orthostatic hypotension | 69.36 | 11.47 | 85 | 28891 | 29396 | 50546752 |
Systemic lupus erythematosus | 67.75 | 11.47 | 3 | 28973 | 140619 | 50435529 |
Fall | 65.48 | 11.47 | 370 | 28606 | 334562 | 50241586 |
Jealous delusion | 63.16 | 11.47 | 12 | 28964 | 28 | 50576120 |
Hyperkinesia | 54.20 | 11.47 | 23 | 28953 | 1429 | 50574719 |
Therapeutic response shortened | 54.11 | 11.47 | 40 | 28936 | 7349 | 50568799 |
Compulsive hoarding | 52.31 | 11.47 | 11 | 28965 | 50 | 50576098 |
Delusion | 51.36 | 11.47 | 45 | 28931 | 10524 | 50565624 |
Drug dispensed to wrong patient | 48.96 | 11.47 | 13 | 28963 | 182 | 50575966 |
Contraindicated product administered | 47.93 | 11.47 | 13 | 28963 | 148945 | 50427203 |
Maternal exposure during pregnancy | 47.69 | 11.47 | 16 | 28960 | 159762 | 50416386 |
Torticollis | 47.14 | 11.47 | 22 | 28954 | 1714 | 50574434 |
Psychotic disorder | 46.70 | 11.47 | 60 | 28916 | 21752 | 50554396 |
Diabetes mellitus inadequate control | 46.64 | 11.47 | 47 | 28929 | 13098 | 50563050 |
Glossodynia | 45.83 | 11.47 | 6 | 28970 | 115563 | 50460585 |
Synovitis | 45.54 | 11.47 | 8 | 28968 | 123857 | 50452291 |
Acute psychosis | 44.88 | 11.47 | 23 | 28953 | 2197 | 50573951 |
Medication error | 43.67 | 11.47 | 76 | 28900 | 36028 | 50540120 |
Neuroleptic malignant syndrome | 41.72 | 11.47 | 41 | 28935 | 11089 | 50565059 |
Somnolence | 39.81 | 11.47 | 185 | 28791 | 154800 | 50421348 |
Abnormal dreams | 39.81 | 11.47 | 37 | 28939 | 9340 | 50566808 |
Abnormal behaviour | 38.86 | 11.47 | 52 | 28924 | 19606 | 50556542 |
Vestibular migraine | 38.44 | 11.47 | 11 | 28965 | 206 | 50575942 |
Sleep attacks | 37.82 | 11.47 | 9 | 28967 | 78 | 50576070 |
Akinesia | 37.64 | 11.47 | 18 | 28958 | 1481 | 50574667 |
Joint swelling | 36.92 | 11.47 | 52 | 28924 | 245234 | 50330914 |
Gait disturbance | 36.30 | 11.47 | 176 | 28800 | 149829 | 50426319 |
Multiple drug therapy | 36.09 | 11.47 | 19 | 28957 | 1918 | 50574230 |
Febrile neutropenia | 34.42 | 11.47 | 7 | 28969 | 97660 | 50478488 |
Psychomotor hyperactivity | 34.37 | 11.47 | 34 | 28942 | 9267 | 50566881 |
Pericarditis | 33.96 | 11.47 | 3 | 28973 | 78686 | 50497462 |
Alopecia | 33.00 | 11.47 | 56 | 28920 | 244991 | 50331157 |
Pituitary haemorrhage | 32.50 | 11.47 | 8 | 28968 | 81 | 50576067 |
Hand deformity | 31.74 | 11.47 | 9 | 28967 | 100190 | 50475958 |
Dopamine dysregulation syndrome | 31.53 | 11.47 | 9 | 28967 | 167 | 50575981 |
Delirium | 31.05 | 11.47 | 68 | 28908 | 38124 | 50538024 |
Malignant polyp | 31.04 | 11.47 | 9 | 28967 | 177 | 50575971 |
Dependence | 31.04 | 11.47 | 17 | 28959 | 1858 | 50574290 |
Dropped head syndrome | 30.89 | 11.47 | 8 | 28968 | 101 | 50576047 |
Blood pressure inadequately controlled | 30.48 | 11.47 | 23 | 28953 | 4357 | 50571791 |
Drug intolerance | 29.56 | 11.47 | 50 | 28926 | 219054 | 50357094 |
Anxiety | 29.34 | 11.47 | 188 | 28788 | 177418 | 50398730 |
Product prescribing error | 29.18 | 11.47 | 47 | 28929 | 20914 | 50555234 |
Bronchopulmonary aspergillosis allergic | 28.99 | 11.47 | 14 | 28962 | 1177 | 50574971 |
Memory impairment | 28.45 | 11.47 | 105 | 28871 | 79255 | 50496893 |
Parkinsonism | 28.44 | 11.47 | 30 | 28946 | 8817 | 50567331 |
Economic problem | 28.25 | 11.47 | 16 | 28960 | 1866 | 50574282 |
Neutropenia | 28.07 | 11.47 | 26 | 28950 | 147939 | 50428209 |
Total lung capacity decreased | 27.92 | 11.47 | 14 | 28962 | 1277 | 50574871 |
Lung opacity | 27.54 | 11.47 | 16 | 28960 | 1957 | 50574191 |
Treatment failure | 27.54 | 11.47 | 23 | 28953 | 137614 | 50438534 |
Hypersensitivity | 27.31 | 11.47 | 51 | 28925 | 215110 | 50361038 |
Stoma site infection | 27.11 | 11.47 | 11 | 28965 | 610 | 50575538 |
Rash | 26.97 | 11.47 | 144 | 28832 | 437327 | 50138821 |
Exercise tolerance decreased | 26.22 | 11.47 | 22 | 28954 | 4852 | 50571296 |
Malignant neoplasm progression | 25.92 | 11.47 | 4 | 28972 | 68120 | 50508028 |
Hyperphagia | 25.66 | 11.47 | 14 | 28962 | 1518 | 50574630 |
Crime | 25.41 | 11.47 | 5 | 28971 | 15 | 50576133 |
Orthostatic intolerance | 25.34 | 11.47 | 12 | 28964 | 966 | 50575182 |
Fibroma | 25.32 | 11.47 | 11 | 28965 | 724 | 50575424 |
Depressed mood | 24.78 | 11.47 | 58 | 28918 | 33965 | 50542183 |
Amnesia | 24.45 | 11.47 | 66 | 28910 | 42194 | 50533954 |
Discomfort | 24.41 | 11.47 | 16 | 28960 | 108364 | 50467784 |
Hyperventilation | 24.24 | 11.47 | 22 | 28954 | 5387 | 50570761 |
Posture abnormal | 24.13 | 11.47 | 15 | 28961 | 2074 | 50574074 |
Deep brain stimulation | 23.22 | 11.47 | 5 | 28971 | 26 | 50576122 |
Oedema peripheral | 22.37 | 11.47 | 161 | 28815 | 157800 | 50418348 |
Abdominal discomfort | 22.08 | 11.47 | 64 | 28912 | 231577 | 50344571 |
Vaccination site oedema | 21.82 | 11.47 | 4 | 28972 | 7 | 50576141 |
Swelling | 21.81 | 11.47 | 52 | 28924 | 200820 | 50375328 |
Chorea | 21.77 | 11.47 | 12 | 28964 | 1328 | 50574820 |
Cognitive disorder | 21.72 | 11.47 | 65 | 28911 | 44058 | 50532090 |
Compulsions | 21.51 | 11.47 | 7 | 28969 | 205 | 50575943 |
Vaccination site bruising | 21.47 | 11.47 | 4 | 28972 | 8 | 50576140 |
Vaccination site pruritus | 21.47 | 11.47 | 4 | 28972 | 8 | 50576140 |
Withdrawal syndrome | 21.23 | 11.47 | 37 | 28939 | 17553 | 50558595 |
Movement disorder | 21.16 | 11.47 | 37 | 28939 | 17595 | 50558553 |
Sleep apnoea syndrome | 21.13 | 11.47 | 44 | 28932 | 23824 | 50552324 |
Nightmare | 20.95 | 11.47 | 35 | 28941 | 16051 | 50560097 |
Therapeutic response changed | 20.91 | 11.47 | 10 | 28966 | 823 | 50575325 |
Female orgasmic disorder | 20.28 | 11.47 | 5 | 28971 | 51 | 50576097 |
Insomnia | 20.20 | 11.47 | 170 | 28806 | 174695 | 50401453 |
Heat stroke | 20.14 | 11.47 | 9 | 28967 | 634 | 50575514 |
Infusion related reaction | 19.95 | 11.47 | 42 | 28934 | 169515 | 50406633 |
Exposure during pregnancy | 19.88 | 11.47 | 24 | 28952 | 120991 | 50455157 |
Snoring | 19.72 | 11.47 | 16 | 28960 | 3368 | 50572780 |
Drug withdrawal syndrome | 19.64 | 11.47 | 44 | 28932 | 25037 | 50551111 |
Coronary artery dissection | 19.08 | 11.47 | 9 | 28967 | 718 | 50575430 |
Confusional state | 19.02 | 11.47 | 176 | 28800 | 185752 | 50390396 |
Drug interaction | 18.96 | 11.47 | 186 | 28790 | 199435 | 50376713 |
Diarrhoea | 18.94 | 11.47 | 231 | 28745 | 588245 | 49987903 |
Serum serotonin increased | 18.79 | 11.47 | 6 | 28970 | 165 | 50575983 |
Product residue present | 18.58 | 11.47 | 16 | 28960 | 3656 | 50572492 |
Stoma site irritation | 18.46 | 11.47 | 6 | 28970 | 175 | 50575973 |
Suspiciousness | 18.43 | 11.47 | 7 | 28969 | 325 | 50575823 |
Inhibitory drug interaction | 18.43 | 11.47 | 13 | 28963 | 2220 | 50573928 |
Restlessness | 18.43 | 11.47 | 43 | 28933 | 25130 | 50551018 |
Therapeutic product effect variable | 18.37 | 11.47 | 10 | 28966 | 1080 | 50575068 |
Orgasm abnormal | 17.98 | 11.47 | 5 | 28971 | 84 | 50576064 |
Narcolepsy | 17.78 | 11.47 | 10 | 28966 | 1150 | 50574998 |
Pre-existing condition improved | 17.56 | 11.47 | 21 | 28955 | 7076 | 50569072 |
Product substitution issue | 17.53 | 11.47 | 30 | 28946 | 14027 | 50562121 |
Parkinson's disease | 17.51 | 11.47 | 10 | 28966 | 1185 | 50574963 |
Rheumatoid arthritis | 17.16 | 11.47 | 59 | 28917 | 202491 | 50373657 |
Stoma site inflammation | 17.05 | 11.47 | 7 | 28969 | 400 | 50575748 |
Meningorrhagia | 16.89 | 11.47 | 5 | 28971 | 106 | 50576042 |
Pancytopenia | 16.85 | 11.47 | 14 | 28962 | 84016 | 50492132 |
Bipolar disorder | 16.73 | 11.47 | 20 | 28956 | 6737 | 50569411 |
Toxicity to various agents | 16.61 | 11.47 | 64 | 28912 | 212435 | 50363713 |
Arthropathy | 16.25 | 11.47 | 42 | 28934 | 157864 | 50418284 |
Blood calcium increased | 16.15 | 11.47 | 21 | 28955 | 7698 | 50568450 |
Feeling abnormal | 16.11 | 11.47 | 125 | 28851 | 125367 | 50450781 |
Product use issue | 15.97 | 11.47 | 39 | 28937 | 149436 | 50426712 |
Stoma site hypergranulation | 15.71 | 11.47 | 6 | 28970 | 283 | 50575865 |
Vaccination site erythema | 15.56 | 11.47 | 4 | 28972 | 49 | 50576099 |
Autonomic nervous system imbalance | 15.45 | 11.47 | 12 | 28964 | 2373 | 50573775 |
Hypercapnia | 15.43 | 11.47 | 16 | 28960 | 4611 | 50571537 |
Off label use | 15.33 | 11.47 | 186 | 28790 | 474240 | 50101908 |
Compulsive sexual behaviour | 14.81 | 11.47 | 4 | 28972 | 60 | 50576088 |
Disease progression | 14.72 | 11.47 | 20 | 28956 | 95846 | 50480302 |
Stomatitis | 14.71 | 11.47 | 22 | 28954 | 101322 | 50474826 |
Aspiration | 14.60 | 11.47 | 22 | 28954 | 9242 | 50566906 |
Dizziness | 14.32 | 11.47 | 278 | 28698 | 346091 | 50230057 |
Stoma site candida | 14.20 | 11.47 | 3 | 28973 | 14 | 50576134 |
Vitamin B6 deficiency | 13.93 | 11.47 | 4 | 28972 | 76 | 50576072 |
Thrombocytopenia | 13.89 | 11.47 | 33 | 28943 | 127640 | 50448508 |
Vaccination site pain | 13.78 | 11.47 | 4 | 28972 | 79 | 50576069 |
Depression | 13.73 | 11.47 | 150 | 28826 | 165273 | 50410875 |
Bulimia nervosa | 13.72 | 11.47 | 6 | 28970 | 401 | 50575747 |
Stoma site reaction | 13.67 | 11.47 | 5 | 28971 | 209 | 50575939 |
Speech disorder | 13.55 | 11.47 | 48 | 28928 | 35500 | 50540648 |
Middle insomnia | 13.47 | 11.47 | 22 | 28954 | 9899 | 50566249 |
Endometrial cancer | 13.46 | 11.47 | 12 | 28964 | 2871 | 50573277 |
Muscle atrophy | 13.35 | 11.47 | 17 | 28959 | 6104 | 50570044 |
Drug abuse | 13.25 | 11.47 | 9 | 28967 | 59837 | 50516311 |
Choking | 13.14 | 11.47 | 20 | 28956 | 8478 | 50567670 |
Balance disorder | 13.07 | 11.47 | 77 | 28899 | 70513 | 50505635 |
Hepatic enzyme increased | 13.04 | 11.47 | 38 | 28938 | 137342 | 50438806 |
Anisomastia | 12.82 | 11.47 | 3 | 28973 | 24 | 50576124 |
Kleptomania | 12.61 | 11.47 | 3 | 28973 | 26 | 50576122 |
Reduced facial expression | 12.51 | 11.47 | 9 | 28967 | 1585 | 50574563 |
Tardive dyskinesia | 12.51 | 11.47 | 18 | 28958 | 7261 | 50568887 |
Ill-defined disorder | 12.39 | 11.47 | 8 | 28968 | 54646 | 50521502 |
Muscle injury | 12.38 | 11.47 | 3 | 28973 | 37108 | 50539040 |
Mucosal inflammation | 12.00 | 11.47 | 4 | 28972 | 40138 | 50536010 |
Suicidal ideation | 11.97 | 11.47 | 63 | 28913 | 55322 | 50520826 |
Blister | 11.96 | 11.47 | 19 | 28957 | 85399 | 50490749 |
Medical device site dryness | 11.88 | 11.47 | 3 | 28973 | 34 | 50576114 |
Accidental overdose | 11.80 | 11.47 | 31 | 28945 | 19502 | 50556646 |
Rheumatoid factor positive | 11.72 | 11.47 | 7 | 28969 | 49852 | 50526296 |
Chronic obstructive pulmonary disease | 11.70 | 11.47 | 61 | 28915 | 53374 | 50522774 |
Product administration error | 11.63 | 11.47 | 31 | 28945 | 19668 | 50556480 |
Skull fracture | 11.59 | 11.47 | 7 | 28969 | 919 | 50575229 |
Device kink | 11.50 | 11.47 | 9 | 28967 | 1798 | 50574350 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Impulse-control disorder | 724.53 | 14.22 | 166 | 18758 | 1059 | 29554544 |
Gambling disorder | 607.04 | 14.22 | 151 | 18773 | 1424 | 29554179 |
Hypersexuality | 573.08 | 14.22 | 140 | 18784 | 1216 | 29554387 |
Hallucination | 416.77 | 14.22 | 292 | 18632 | 44420 | 29511183 |
Dyskinesia | 322.21 | 14.22 | 185 | 18739 | 19876 | 29535727 |
On and off phenomenon | 263.54 | 14.22 | 82 | 18842 | 1846 | 29553757 |
Dopamine dysregulation syndrome | 223.79 | 14.22 | 50 | 18874 | 279 | 29555324 |
Gambling | 196.34 | 14.22 | 41 | 18883 | 156 | 29555447 |
Hallucination, visual | 187.88 | 14.22 | 118 | 18806 | 14897 | 29540706 |
Compulsive shopping | 178.28 | 14.22 | 43 | 18881 | 351 | 29555252 |
Stereotypy | 120.11 | 14.22 | 35 | 18889 | 624 | 29554979 |
Jealous delusion | 116.33 | 14.22 | 27 | 18897 | 183 | 29555420 |
Obsessive-compulsive disorder | 112.26 | 14.22 | 56 | 18868 | 4520 | 29551083 |
Freezing phenomenon | 109.17 | 14.22 | 38 | 18886 | 1225 | 29554378 |
Delusion | 105.95 | 14.22 | 74 | 18850 | 11142 | 29544461 |
Paraphilia | 98.93 | 14.22 | 20 | 18904 | 62 | 29555541 |
Restless legs syndrome | 92.66 | 14.22 | 57 | 18867 | 6927 | 29548676 |
Needle fatigue | 88.24 | 14.22 | 27 | 18897 | 573 | 29555030 |
Gait disturbance | 87.23 | 14.22 | 163 | 18761 | 73186 | 29482417 |
Gait spastic | 84.52 | 14.22 | 27 | 18897 | 663 | 29554940 |
Muscle rigidity | 84.04 | 14.22 | 60 | 18864 | 9351 | 29546252 |
Libido increased | 83.36 | 14.22 | 27 | 18897 | 694 | 29554909 |
Relapsing-remitting multiple sclerosis | 82.95 | 14.22 | 27 | 18897 | 705 | 29554898 |
Sudden onset of sleep | 81.90 | 14.22 | 23 | 18901 | 357 | 29555246 |
Fall | 80.96 | 14.22 | 273 | 18651 | 176905 | 29378698 |
Parkinsonism hyperpyrexia syndrome | 80.14 | 14.22 | 17 | 18907 | 71 | 29555532 |
Bradykinesia | 75.27 | 14.22 | 39 | 18885 | 3408 | 29552195 |
Abnormal behaviour | 73.32 | 14.22 | 82 | 18842 | 23045 | 29532558 |
Stoma site erythema | 70.29 | 14.22 | 23 | 18901 | 611 | 29554992 |
Psychomotor hyperactivity | 70.21 | 14.22 | 51 | 18873 | 8162 | 29547441 |
Nocturia | 69.39 | 14.22 | 51 | 18873 | 8311 | 29547292 |
Insomnia | 69.15 | 14.22 | 166 | 18758 | 88595 | 29467008 |
Hypertonic bladder | 64.85 | 14.22 | 27 | 18897 | 1429 | 29554174 |
Monoparesis | 64.18 | 14.22 | 29 | 18895 | 1874 | 29553729 |
Memory impairment | 63.25 | 14.22 | 96 | 18828 | 36374 | 29519229 |
Micturition urgency | 63.02 | 14.22 | 40 | 18884 | 5133 | 29550470 |
Stoma site discharge | 61.98 | 14.22 | 23 | 18901 | 894 | 29554709 |
Hyperkinesia | 59.16 | 14.22 | 26 | 18898 | 1573 | 29554030 |
Movement disorder | 56.20 | 14.22 | 49 | 18875 | 10188 | 29545415 |
Impulsive behaviour | 54.31 | 14.22 | 26 | 18898 | 1917 | 29553686 |
Encephalitis toxic | 51.23 | 14.22 | 15 | 18909 | 272 | 29555331 |
Toxicity to various agents | 50.54 | 14.22 | 24 | 18900 | 173637 | 29381966 |
Binge eating | 50.52 | 14.22 | 12 | 18912 | 91 | 29555512 |
Muscle spasticity | 50.31 | 14.22 | 34 | 18890 | 4849 | 29550754 |
Agitation | 50.05 | 14.22 | 105 | 18819 | 51199 | 29504404 |
Psychotic disorder | 49.40 | 14.22 | 63 | 18861 | 20291 | 29535312 |
Balance disorder | 48.82 | 14.22 | 85 | 18839 | 36085 | 29519518 |
Compulsive hoarding | 48.76 | 14.22 | 9 | 18915 | 14 | 29555589 |
Central nervous system lesion | 48.11 | 14.22 | 35 | 18889 | 5613 | 29549990 |
Confusional state | 48.03 | 14.22 | 185 | 18739 | 127692 | 29427911 |
Dysarthria | 47.52 | 14.22 | 77 | 18847 | 30834 | 29524769 |
Stoma site pain | 46.34 | 14.22 | 16 | 18908 | 503 | 29555100 |
Tremor | 46.32 | 14.22 | 127 | 18797 | 73411 | 29482192 |
Neuroleptic malignant syndrome | 45.68 | 14.22 | 54 | 18870 | 16094 | 29539509 |
Aggression | 44.72 | 14.22 | 81 | 18843 | 35460 | 29520143 |
Mania | 44.63 | 14.22 | 40 | 18884 | 8623 | 29546980 |
Voyeurism | 44.49 | 14.22 | 7 | 18917 | 0 | 29555603 |
Dependence | 42.11 | 14.22 | 18 | 18906 | 1017 | 29554586 |
Anxiety | 41.95 | 14.22 | 135 | 18789 | 85230 | 29470373 |
Sleep attacks | 41.55 | 14.22 | 11 | 18913 | 135 | 29555468 |
Delirium | 41.20 | 14.22 | 83 | 18841 | 39314 | 29516289 |
Compulsive sexual behaviour | 40.56 | 14.22 | 12 | 18912 | 226 | 29555377 |
Febrile neutropenia | 40.28 | 14.22 | 11 | 18913 | 112229 | 29443374 |
Neutropenia | 40.18 | 14.22 | 17 | 18907 | 131694 | 29423909 |
Somnolence | 39.49 | 14.22 | 141 | 18783 | 93814 | 29461789 |
Pyrexia | 39.38 | 14.22 | 78 | 18846 | 287544 | 29268059 |
Hyperphagia | 38.99 | 14.22 | 18 | 18906 | 1222 | 29554381 |
Dystonia | 38.75 | 14.22 | 39 | 18885 | 9710 | 29545893 |
Economic problem | 38.72 | 14.22 | 18 | 18906 | 1242 | 29554361 |
Ataxia | 38.49 | 14.22 | 43 | 18881 | 12060 | 29543543 |
Hypomania | 37.40 | 14.22 | 21 | 18903 | 2154 | 29553449 |
Posture abnormal | 36.77 | 14.22 | 20 | 18904 | 1927 | 29553676 |
Acute kidney injury | 36.25 | 14.22 | 72 | 18852 | 265195 | 29290408 |
Device dislocation | 36.18 | 14.22 | 27 | 18897 | 4500 | 29551103 |
Diarrhoea | 36.16 | 14.22 | 102 | 18822 | 332596 | 29223007 |
Multiple sclerosis relapse | 35.34 | 14.22 | 40 | 18884 | 11379 | 29544224 |
Restlessness | 35.17 | 14.22 | 56 | 18868 | 22089 | 29533514 |
Suspiciousness | 33.48 | 14.22 | 11 | 18913 | 296 | 29555307 |
Dementia | 32.99 | 14.22 | 39 | 18885 | 11619 | 29543984 |
Paranoia | 32.98 | 14.22 | 36 | 18888 | 9841 | 29545762 |
Therapeutic product effect variable | 31.94 | 14.22 | 18 | 18906 | 1859 | 29553744 |
Excessive masturbation | 31.44 | 14.22 | 8 | 18916 | 83 | 29555520 |
Personality change | 31.26 | 14.22 | 25 | 18899 | 4613 | 29550990 |
Sexually inappropriate behaviour | 30.57 | 14.22 | 11 | 18913 | 391 | 29555212 |
Bipolar I disorder | 30.46 | 14.22 | 13 | 18911 | 732 | 29554871 |
Road traffic accident | 29.89 | 14.22 | 43 | 18881 | 15518 | 29540085 |
Platelet count decreased | 29.60 | 14.22 | 15 | 18909 | 104657 | 29450946 |
Dizziness | 28.96 | 14.22 | 214 | 18710 | 189470 | 29366133 |
Condition aggravated | 28.91 | 14.22 | 176 | 18748 | 146119 | 29409484 |
Pollakiuria | 28.56 | 14.22 | 44 | 18880 | 16872 | 29538731 |
Akinesia | 28.34 | 14.22 | 17 | 18907 | 1973 | 29553630 |
Pancytopenia | 28.27 | 14.22 | 9 | 18915 | 83159 | 29472444 |
Acute psychosis | 28.22 | 14.22 | 16 | 18908 | 1671 | 29553932 |
Anticholinergic syndrome | 28.18 | 14.22 | 13 | 18911 | 881 | 29554722 |
Dropped head syndrome | 28.14 | 14.22 | 8 | 18916 | 130 | 29555473 |
Hypervigilance | 28.08 | 14.22 | 8 | 18916 | 131 | 29555472 |
Reduced facial expression | 27.81 | 14.22 | 12 | 18912 | 694 | 29554909 |
Embedded device | 27.79 | 14.22 | 9 | 18915 | 231 | 29555372 |
Somnambulism | 27.68 | 14.22 | 19 | 18905 | 2779 | 29552824 |
Obsessive-compulsive personality disorder | 27.33 | 14.22 | 8 | 18916 | 145 | 29555458 |
Hallucination, tactile | 26.43 | 14.22 | 9 | 18915 | 271 | 29555332 |
Sleep disorder | 26.23 | 14.22 | 52 | 18872 | 24334 | 29531269 |
Parkinson's disease | 25.76 | 14.22 | 14 | 18910 | 1347 | 29554256 |
Compulsions | 25.62 | 14.22 | 8 | 18916 | 182 | 29555421 |
Delusional disorder, jealous type | 25.42 | 14.22 | 4 | 18920 | 0 | 29555603 |
Depressive symptom | 25.31 | 14.22 | 15 | 18909 | 1702 | 29553901 |
Cognitive disorder | 25.15 | 14.22 | 50 | 18874 | 23449 | 29532154 |
Human ehrlichiosis | 25.10 | 14.22 | 8 | 18916 | 195 | 29555408 |
Spontaneous penile erection | 24.83 | 14.22 | 8 | 18916 | 202 | 29555401 |
Dysstasia | 24.75 | 14.22 | 32 | 18892 | 10442 | 29545161 |
Contraindicated product prescribed | 24.52 | 14.22 | 9 | 18915 | 339 | 29555264 |
Stoma site haemorrhage | 24.41 | 14.22 | 11 | 18913 | 706 | 29554897 |
Disturbance in attention | 23.42 | 14.22 | 46 | 18878 | 21378 | 29534225 |
Device occlusion | 23.33 | 14.22 | 23 | 18901 | 5585 | 29550018 |
Depression | 23.28 | 14.22 | 112 | 18812 | 85035 | 29470568 |
Drug withdrawal syndrome | 22.62 | 14.22 | 41 | 18883 | 17943 | 29537660 |
Stoma site inflammation | 22.61 | 14.22 | 9 | 18915 | 424 | 29555179 |
Stoma site hypergranulation | 22.59 | 14.22 | 7 | 18917 | 155 | 29555448 |
Sleep-related eating disorder | 22.41 | 14.22 | 8 | 18916 | 278 | 29555325 |
Inappropriate antidiuretic hormone secretion | 22.16 | 14.22 | 31 | 18893 | 10901 | 29544702 |
Cardiac dysfunction | 22.08 | 14.22 | 14 | 18910 | 1793 | 29553810 |
Withdrawal syndrome | 22.03 | 14.22 | 31 | 18893 | 10961 | 29544642 |
Food interaction | 22.03 | 14.22 | 11 | 18913 | 889 | 29554714 |
Sleep apnoea syndrome | 21.98 | 14.22 | 40 | 18884 | 17559 | 29538044 |
Rapid eye movements sleep abnormal | 21.83 | 14.22 | 7 | 18917 | 174 | 29555429 |
Verbal abuse | 21.79 | 14.22 | 7 | 18917 | 175 | 29555428 |
Malignant neoplasm progression | 21.77 | 14.22 | 10 | 18914 | 73849 | 29481754 |
Erectile dysfunction | 21.33 | 14.22 | 40 | 18884 | 17969 | 29537634 |
Device issue | 20.33 | 14.22 | 25 | 18899 | 7755 | 29547848 |
Parkinsonism | 20.02 | 14.22 | 24 | 18900 | 7254 | 29548349 |
Bradycardia | 19.90 | 14.22 | 89 | 18835 | 65540 | 29490063 |
White blood cell count decreased | 19.35 | 14.22 | 15 | 18909 | 83347 | 29472256 |
Abnormal dreams | 19.33 | 14.22 | 23 | 18901 | 6897 | 29548706 |
Sepsis | 19.20 | 14.22 | 39 | 18885 | 142643 | 29412960 |
Motor dysfunction | 18.73 | 14.22 | 21 | 18903 | 5909 | 29549694 |
Marital problem | 18.69 | 14.22 | 5 | 18919 | 64 | 29555539 |
Nightmare | 18.30 | 14.22 | 29 | 18895 | 11388 | 29544215 |
Suicidal ideation | 18.02 | 14.22 | 56 | 18868 | 34660 | 29520943 |
Sexual activity increased | 17.95 | 14.22 | 4 | 18920 | 22 | 29555581 |
Cardiac arrest | 17.92 | 14.22 | 17 | 18907 | 85574 | 29470029 |
Eosinophilic fasciitis | 17.90 | 14.22 | 5 | 18919 | 76 | 29555527 |
Sopor | 17.84 | 14.22 | 28 | 18896 | 10906 | 29544697 |
Visual impairment | 17.39 | 14.22 | 50 | 18874 | 29658 | 29525945 |
Torticollis | 17.29 | 14.22 | 10 | 18914 | 1085 | 29554518 |
Gait inability | 17.19 | 14.22 | 37 | 18887 | 18338 | 29537265 |
Lung hyperinflation | 17.19 | 14.22 | 9 | 18915 | 803 | 29554800 |
Hyperkalaemia | 17.05 | 14.22 | 9 | 18915 | 61383 | 29494220 |
Device kink | 17 | 14.22 | 7 | 18917 | 360 | 29555243 |
Device effect decreased | 16.99 | 14.22 | 3 | 18921 | 3 | 29555600 |
Intentional medical device removal by patient | 16.93 | 14.22 | 6 | 18918 | 204 | 29555399 |
Device alarm issue | 16.91 | 14.22 | 8 | 18916 | 574 | 29555029 |
Mobility decreased | 16.68 | 14.22 | 45 | 18879 | 25735 | 29529868 |
Tension | 16.62 | 14.22 | 12 | 18912 | 1901 | 29553702 |
Disease progression | 16.31 | 14.22 | 17 | 18907 | 81899 | 29473704 |
Neutrophil count decreased | 16.13 | 14.22 | 4 | 18920 | 43563 | 29512040 |
Rash | 15.91 | 14.22 | 65 | 18859 | 189754 | 29365849 |
Mental impairment | 15.74 | 14.22 | 24 | 18900 | 9117 | 29546486 |
Troponin increased | 15.66 | 14.22 | 24 | 18900 | 9159 | 29546444 |
Stoma site infection | 15.48 | 14.22 | 8 | 18916 | 695 | 29554908 |
Rapid eye movement sleep behaviour disorder | 15.42 | 14.22 | 5 | 18919 | 129 | 29555474 |
Interstitial lung disease | 15.25 | 14.22 | 9 | 18915 | 57709 | 29497894 |
Therapeutic response shortened | 15.19 | 14.22 | 17 | 18907 | 4774 | 29550829 |
Paedophilia | 15.17 | 14.22 | 3 | 18921 | 8 | 29555595 |
Excessive exercise | 15.17 | 14.22 | 3 | 18921 | 8 | 29555595 |
Pleurothotonus | 15.12 | 14.22 | 9 | 18915 | 1029 | 29554574 |
Micturition disorder | 14.44 | 14.22 | 11 | 18913 | 1890 | 29553713 |
Anaemia | 14.34 | 14.22 | 73 | 18851 | 200878 | 29354725 |
Ascites | 14.28 | 14.22 | 3 | 18921 | 36616 | 29518987 |
IVth nerve paresis | 14.24 | 14.22 | 3 | 18921 | 12 | 29555591 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Impulse-control disorder | 719.08 | 11.43 | 170 | 37084 | 1418 | 64460060 |
Gambling disorder | 599.38 | 11.43 | 152 | 37102 | 1742 | 64459736 |
Dyskinesia | 526.20 | 11.43 | 311 | 36943 | 39077 | 64422401 |
Hallucination | 422.35 | 11.43 | 344 | 36910 | 72444 | 64389034 |
Hypersexuality | 391.60 | 11.43 | 103 | 37151 | 1376 | 64460102 |
On and off phenomenon | 376.09 | 11.43 | 112 | 37142 | 2407 | 64459071 |
Hallucination, visual | 276.09 | 11.43 | 182 | 37072 | 27652 | 64433826 |
Compulsive shopping | 263.90 | 11.43 | 66 | 37188 | 711 | 64460767 |
Dopamine dysregulation syndrome | 231.11 | 11.43 | 54 | 37200 | 425 | 64461053 |
Parkinsonism hyperpyrexia syndrome | 211.48 | 11.43 | 44 | 37210 | 186 | 64461292 |
Gambling | 184.85 | 11.43 | 41 | 37213 | 248 | 64461230 |
Jealous delusion | 149.58 | 11.43 | 33 | 37221 | 194 | 64461284 |
Stereotypy | 145.77 | 11.43 | 42 | 37212 | 800 | 64460678 |
Freezing phenomenon | 136.25 | 11.43 | 46 | 37208 | 1500 | 64459978 |
Dystonia | 134.90 | 11.43 | 101 | 37153 | 18764 | 64442714 |
Restless legs syndrome | 129.95 | 11.43 | 95 | 37159 | 17021 | 64444457 |
Bradykinesia | 129.31 | 11.43 | 67 | 37187 | 6493 | 64454985 |
Delusion | 116.83 | 11.43 | 91 | 37163 | 17923 | 64443555 |
Fall | 114.56 | 11.43 | 510 | 36744 | 416316 | 64045162 |
Muscle rigidity | 110.58 | 11.43 | 87 | 37167 | 17386 | 64444092 |
Stoma site erythema | 109.72 | 11.43 | 37 | 37217 | 1202 | 64460276 |
Obsessive-compulsive disorder | 108.96 | 11.43 | 54 | 37200 | 4764 | 64456714 |
Stoma site discharge | 102.32 | 11.43 | 38 | 37216 | 1644 | 64459834 |
Hyperkinesia | 100.28 | 11.43 | 42 | 37212 | 2504 | 64458974 |
Tremor | 96.44 | 11.43 | 243 | 37011 | 147987 | 64313491 |
Psychotic disorder | 94.36 | 11.43 | 108 | 37146 | 34470 | 64427008 |
Binge eating | 94.01 | 11.43 | 26 | 37228 | 424 | 64461054 |
Compulsive hoarding | 91.06 | 11.43 | 18 | 37236 | 55 | 64461423 |
Neuroleptic malignant syndrome | 91.05 | 11.43 | 91 | 37163 | 24905 | 64436573 |
Sudden onset of sleep | 86.49 | 11.43 | 26 | 37228 | 577 | 64460901 |
Pleurothotonus | 84.10 | 11.43 | 36 | 37218 | 2266 | 64459212 |
Needle fatigue | 82.82 | 11.43 | 25 | 37229 | 563 | 64460915 |
Stoma site pain | 81.61 | 11.43 | 29 | 37225 | 1104 | 64460374 |
Abnormal behaviour | 80.13 | 11.43 | 98 | 37156 | 33524 | 64427954 |
Gait disturbance | 77.47 | 11.43 | 247 | 37007 | 171908 | 64289570 |
Gait spastic | 72.58 | 11.43 | 25 | 37229 | 867 | 64460611 |
Therapeutic response shortened | 69.49 | 11.43 | 53 | 37201 | 10117 | 64451361 |
Acute psychosis | 67.35 | 11.43 | 36 | 37218 | 3716 | 64457762 |
Relapsing-remitting multiple sclerosis | 67.28 | 11.43 | 25 | 37229 | 1083 | 64460395 |
Torticollis | 66.43 | 11.43 | 30 | 37224 | 2147 | 64459331 |
Akinesia | 65.18 | 11.43 | 33 | 37221 | 3046 | 64458432 |
Orthostatic hypotension | 64.70 | 11.43 | 105 | 37149 | 46633 | 64414845 |
Febrile neutropenia | 63.84 | 11.43 | 15 | 37239 | 187642 | 64273836 |
Delirium | 63.41 | 11.43 | 130 | 37124 | 69064 | 64392414 |
Paraphilia | 63.05 | 11.43 | 13 | 37241 | 52 | 64461426 |
Camptocormia | 61.56 | 11.43 | 19 | 37235 | 462 | 64461016 |
Insomnia | 59.46 | 11.43 | 249 | 37005 | 197587 | 64263891 |
Sleep attacks | 59.36 | 11.43 | 15 | 37239 | 169 | 64461309 |
Nocturia | 58.88 | 11.43 | 50 | 37204 | 11115 | 64450363 |
Neutropenia | 58.24 | 11.43 | 33 | 37221 | 239591 | 64221887 |
Movement disorder | 55.48 | 11.43 | 66 | 37188 | 21934 | 64439544 |
Psychomotor hyperactivity | 55.20 | 11.43 | 54 | 37200 | 14397 | 64447081 |
Impulsive behaviour | 54.79 | 11.43 | 28 | 37226 | 2635 | 64458843 |
Toxicity to various agents | 52.04 | 11.43 | 81 | 37173 | 363432 | 64098046 |
Anxiety | 51.77 | 11.43 | 243 | 37011 | 202406 | 64259072 |
Therapeutic product effect variable | 51.26 | 11.43 | 23 | 37231 | 1621 | 64459857 |
Dropped head syndrome | 50.47 | 11.43 | 14 | 37240 | 231 | 64461247 |
Drug withdrawal syndrome | 49.85 | 11.43 | 75 | 37179 | 31216 | 64430262 |
Monoparesis | 49.45 | 11.43 | 27 | 37227 | 2907 | 64458571 |
Posture abnormal | 48.33 | 11.43 | 28 | 37226 | 3378 | 64458100 |
Encephalitis toxic | 48.08 | 11.43 | 14 | 37240 | 277 | 64461201 |
Suspiciousness | 45.90 | 11.43 | 16 | 37238 | 575 | 64460903 |
Hypertonic bladder | 45.61 | 11.43 | 27 | 37227 | 3391 | 64458087 |
Memory impairment | 44.16 | 11.43 | 129 | 37125 | 85553 | 64375925 |
Micturition urgency | 42.00 | 11.43 | 40 | 37214 | 10319 | 64451159 |
Cognitive disorder | 41.89 | 11.43 | 96 | 37158 | 54991 | 64406487 |
Restlessness | 41.57 | 11.43 | 79 | 37175 | 39706 | 64421772 |
Somnolence | 41.36 | 11.43 | 229 | 37025 | 203416 | 64258062 |
Parkinsonism | 41.08 | 11.43 | 46 | 37208 | 14327 | 64447151 |
Agitation | 40.81 | 11.43 | 128 | 37126 | 88239 | 64373239 |
Pancytopenia | 40.54 | 11.43 | 16 | 37238 | 143293 | 64318185 |
Drug dispensed to wrong patient | 40.38 | 11.43 | 13 | 37241 | 364 | 64461114 |
Libido increased | 40.29 | 11.43 | 20 | 37234 | 1770 | 64459708 |
Voyeurism | 38.74 | 11.43 | 6 | 37248 | 0 | 64461478 |
Malignant neoplasm progression | 38.42 | 11.43 | 9 | 37245 | 112862 | 64348616 |
Confusional state | 38.23 | 11.43 | 270 | 36984 | 260874 | 64200604 |
Aggression | 37.87 | 11.43 | 83 | 37171 | 46149 | 64415329 |
Economic problem | 36.51 | 11.43 | 20 | 37234 | 2167 | 64459311 |
Rash | 36.45 | 11.43 | 139 | 37115 | 458410 | 64003068 |
Hyperphagia | 36.14 | 11.43 | 20 | 37234 | 2211 | 64459267 |
Medication error | 35.72 | 11.43 | 85 | 37169 | 49881 | 64411597 |
Withdrawal syndrome | 35.57 | 11.43 | 55 | 37199 | 23437 | 64438041 |
Multiple sclerosis relapse | 35.01 | 11.43 | 75 | 37179 | 41060 | 64420418 |
Balance disorder | 34.63 | 11.43 | 117 | 37137 | 83809 | 64377669 |
Depressive symptom | 34.22 | 11.43 | 25 | 37229 | 4471 | 64457007 |
Central nervous system lesion | 34.00 | 11.43 | 38 | 37216 | 11811 | 64449667 |
Pyrexia | 33.91 | 11.43 | 187 | 37067 | 558457 | 63903021 |
Synovitis | 33.53 | 11.43 | 8 | 37246 | 99082 | 64362396 |
Compulsions | 33.29 | 11.43 | 11 | 37243 | 335 | 64461143 |
Nightmare | 32.98 | 11.43 | 50 | 37204 | 20943 | 64440535 |
Abnormal dreams | 32.83 | 11.43 | 35 | 37219 | 10321 | 64451157 |
Diarrhoea | 32.79 | 11.43 | 264 | 36990 | 722440 | 63739038 |
Acute kidney injury | 32.67 | 11.43 | 141 | 37113 | 449099 | 64012379 |
Reduced facial expression | 31.67 | 11.43 | 18 | 37236 | 2095 | 64459383 |
Multiple drug therapy | 30.58 | 11.43 | 18 | 37236 | 2236 | 64459242 |
Dementia | 30.58 | 11.43 | 48 | 37206 | 20718 | 64440760 |
Mania | 30.26 | 11.43 | 42 | 37212 | 16244 | 64445234 |
Condition aggravated | 30.06 | 11.43 | 338 | 36916 | 372088 | 64089390 |
Dizziness | 29.30 | 11.43 | 378 | 36876 | 429785 | 64031693 |
Contraindicated product administered | 28.95 | 11.43 | 13 | 37241 | 107816 | 64353662 |
Depressed mood | 28.49 | 11.43 | 69 | 37185 | 40943 | 64420535 |
Stoma site infection | 28.39 | 11.43 | 14 | 37240 | 1221 | 64460257 |
Excessive masturbation | 28.37 | 11.43 | 7 | 37247 | 71 | 64461407 |
Inappropriate antidiuretic hormone secretion | 28.06 | 11.43 | 48 | 37206 | 22241 | 64439237 |
Malignant polyp | 27.30 | 11.43 | 8 | 37246 | 162 | 64461316 |
Oedema peripheral | 26.53 | 11.43 | 210 | 37044 | 210107 | 64251371 |
Sexually inappropriate behaviour | 26.38 | 11.43 | 10 | 37244 | 458 | 64461020 |
Platelet count decreased | 26.29 | 11.43 | 35 | 37219 | 167676 | 64293802 |
Blood pressure inadequately controlled | 26.14 | 11.43 | 23 | 37231 | 5361 | 64456117 |
Dependence | 26.11 | 11.43 | 16 | 37238 | 2139 | 64459339 |
Delusional disorder, jealous type | 25.83 | 11.43 | 4 | 37250 | 0 | 64461478 |
Dysarthria | 25.55 | 11.43 | 84 | 37170 | 59322 | 64402156 |
Personality change | 25.41 | 11.43 | 28 | 37226 | 8565 | 64452913 |
Marital problem | 25.23 | 11.43 | 8 | 37246 | 213 | 64461265 |
Sleep apnoea syndrome | 24.93 | 11.43 | 54 | 37200 | 29778 | 64431700 |
Obsessive-compulsive personality disorder | 24.82 | 11.43 | 7 | 37247 | 123 | 64461355 |
Bronchopulmonary aspergillosis allergic | 24.80 | 11.43 | 14 | 37240 | 1608 | 64459870 |
Snoring | 24.75 | 11.43 | 21 | 37233 | 4661 | 64456817 |
Compulsive sexual behaviour | 24.26 | 11.43 | 8 | 37246 | 242 | 64461236 |
Erectile dysfunction | 24.12 | 11.43 | 33 | 37221 | 12594 | 64448884 |
Total lung capacity decreased | 24.02 | 11.43 | 14 | 37240 | 1708 | 64459770 |
Bipolar I disorder | 23.66 | 11.43 | 14 | 37240 | 1757 | 64459721 |
Kleptomania | 23.51 | 11.43 | 5 | 37249 | 24 | 64461454 |
Pericarditis | 23.32 | 11.43 | 4 | 37250 | 62512 | 64398966 |
Diabetes mellitus inadequate control | 23.09 | 11.43 | 43 | 37211 | 21278 | 64440200 |
Product prescribing error | 23.08 | 11.43 | 58 | 37196 | 35211 | 64426267 |
Joint swelling | 22.98 | 11.43 | 57 | 37197 | 215325 | 64246153 |
Pituitary haemorrhage | 22.83 | 11.43 | 8 | 37246 | 292 | 64461186 |
Stomatitis | 22.70 | 11.43 | 18 | 37236 | 109587 | 64351891 |
Hallucination, tactile | 22.55 | 11.43 | 9 | 37245 | 474 | 64461004 |
Cardiac arrest | 22.32 | 11.43 | 34 | 37220 | 154030 | 64307448 |
Orthostatic intolerance | 22.30 | 11.43 | 13 | 37241 | 1587 | 64459891 |
Device occlusion | 22.18 | 11.43 | 28 | 37226 | 9885 | 64451593 |
Maternal exposure during pregnancy | 22.15 | 11.43 | 14 | 37240 | 95870 | 64365608 |
Chorea | 22.09 | 11.43 | 14 | 37240 | 1986 | 64459492 |
Ataxia | 22.02 | 11.43 | 43 | 37211 | 22041 | 64439437 |
Troponin increased | 21.85 | 11.43 | 35 | 37219 | 15364 | 64446114 |
Vaccination site bruising | 21.79 | 11.43 | 4 | 37250 | 7 | 64461471 |
Vaccination site oedema | 21.44 | 11.43 | 4 | 37250 | 8 | 64461470 |
Vaccination site pruritus | 21.44 | 11.43 | 4 | 37250 | 8 | 64461470 |
Hand deformity | 21.36 | 11.43 | 5 | 37249 | 62766 | 64398712 |
Human ehrlichiosis | 20.89 | 11.43 | 8 | 37246 | 377 | 64461101 |
Treatment failure | 20.85 | 11.43 | 22 | 37232 | 116794 | 64344684 |
Pollakiuria | 20.79 | 11.43 | 52 | 37202 | 31478 | 64430000 |
Autonomic nervous system imbalance | 20.76 | 11.43 | 18 | 37236 | 4114 | 64457364 |
Spontaneous penile erection | 20.74 | 11.43 | 6 | 37248 | 116 | 64461362 |
Food interaction | 20.66 | 11.43 | 12 | 37242 | 1454 | 64460024 |
Paranoia | 20.30 | 11.43 | 35 | 37219 | 16317 | 64445161 |
Product residue present | 20.20 | 11.43 | 16 | 37238 | 3226 | 64458252 |
Rapid eye movements sleep abnormal | 20.12 | 11.43 | 7 | 37247 | 250 | 64461228 |
Verbal abuse | 19.94 | 11.43 | 7 | 37247 | 257 | 64461221 |
Drug intolerance | 19.85 | 11.43 | 50 | 37204 | 187942 | 64273536 |
Muscle spasticity | 19.81 | 11.43 | 35 | 37219 | 16634 | 64444844 |
Hyperventilation | 19.73 | 11.43 | 22 | 37232 | 6818 | 64454660 |
Vestibular migraine | 19.67 | 11.43 | 6 | 37248 | 140 | 64461338 |
Device dislocation | 19.64 | 11.43 | 40 | 37214 | 21138 | 64440340 |
Hypomania | 19.52 | 11.43 | 20 | 37234 | 5634 | 64455844 |
Hypervigilance | 19.47 | 11.43 | 8 | 37246 | 454 | 64461024 |
Hypersensitivity | 19.42 | 11.43 | 54 | 37200 | 196398 | 64265080 |
Mucosal inflammation | 19.39 | 11.43 | 6 | 37248 | 62578 | 64398900 |
Dysstasia | 19.37 | 11.43 | 42 | 37212 | 23173 | 64438305 |
Paedophilia | 19.37 | 11.43 | 3 | 37251 | 0 | 64461478 |
Device kink | 19.07 | 11.43 | 12 | 37242 | 1681 | 64459797 |
Glossodynia | 18.66 | 11.43 | 7 | 37247 | 64689 | 64396789 |
Lung opacity | 18.26 | 11.43 | 15 | 37239 | 3184 | 64458294 |
White blood cell count decreased | 18.25 | 11.43 | 40 | 37214 | 157797 | 64303681 |
Product substitution issue | 18.08 | 11.43 | 35 | 37219 | 17826 | 64443652 |
Therapeutic response unexpected | 18.06 | 11.43 | 34 | 37220 | 16967 | 64444511 |
Bone marrow failure | 18.04 | 11.43 | 3 | 37251 | 47949 | 64413529 |
Disease progression | 18.00 | 11.43 | 34 | 37220 | 141646 | 64319832 |
Stoma site inflammation | 17.80 | 11.43 | 8 | 37246 | 566 | 64460912 |
Thrombocytopenia | 17.64 | 11.43 | 68 | 37186 | 223733 | 64237745 |
Disturbance in attention | 17.59 | 11.43 | 58 | 37196 | 41016 | 64420462 |
Female orgasmic disorder | 17.41 | 11.43 | 4 | 37250 | 29 | 64461449 |
Ascites | 17.40 | 11.43 | 7 | 37247 | 61994 | 64399484 |
Urticaria | 17.31 | 11.43 | 37 | 37217 | 147280 | 64314198 |
Stoma site hypergranulation | 17.18 | 11.43 | 7 | 37247 | 389 | 64461089 |
Suicidal ideation | 17.10 | 11.43 | 80 | 37174 | 66462 | 64395016 |
Hepatocellular injury | 16.64 | 11.43 | 3 | 37251 | 45232 | 64416246 |
Drug hypersensitivity | 16.43 | 11.43 | 76 | 37178 | 237739 | 64223739 |
Anticholinergic syndrome | 16.26 | 11.43 | 13 | 37241 | 2656 | 64458822 |
Sleep disorder | 16.25 | 11.43 | 73 | 37181 | 59636 | 64401842 |
Obsessive thoughts | 16.15 | 11.43 | 9 | 37245 | 1008 | 64460470 |
Serum serotonin increased | 15.89 | 11.43 | 6 | 37248 | 272 | 64461206 |
Discomfort | 15.86 | 11.43 | 14 | 37240 | 80864 | 64380614 |
Device issue | 15.61 | 11.43 | 38 | 37216 | 22610 | 64438868 |
Feeling abnormal | 15.53 | 11.43 | 131 | 37123 | 133471 | 64328007 |
Prescribed underdose | 15.50 | 11.43 | 33 | 37221 | 17982 | 64443496 |
Alanine aminotransferase increased | 15.45 | 11.43 | 36 | 37218 | 138995 | 64322483 |
Drug reaction with eosinophilia and systemic symptoms | 15.41 | 11.43 | 6 | 37248 | 54211 | 64407267 |
Hepatic function abnormal | 15.40 | 11.43 | 9 | 37245 | 64304 | 64397174 |
Intentional medical device removal by patient | 15.25 | 11.43 | 6 | 37248 | 304 | 64461174 |
Delusion of replacement | 15.20 | 11.43 | 5 | 37249 | 150 | 64461328 |
Vaccination site erythema | 15.16 | 11.43 | 4 | 37250 | 54 | 64461424 |
Choking | 15.02 | 11.43 | 24 | 37230 | 10514 | 64450964 |
Contraindicated product prescribed | 15 | 11.43 | 9 | 37245 | 1158 | 64460320 |
Stoma site candida | 14.98 | 11.43 | 3 | 37251 | 10 | 64461468 |
Parkinson's disease | 14.73 | 11.43 | 10 | 37244 | 1591 | 64459887 |
Hiccups | 14.67 | 11.43 | 21 | 37233 | 8355 | 64453123 |
Cardiac dysfunction | 14.54 | 11.43 | 13 | 37241 | 3093 | 64458385 |
Orgasm abnormal | 14.53 | 11.43 | 5 | 37249 | 173 | 64461305 |
Exercise tolerance decreased | 14.50 | 11.43 | 20 | 37234 | 7690 | 64453788 |
Off label use | 14.48 | 11.43 | 268 | 36986 | 632538 | 63828940 |
Micturition disorder | 14.39 | 11.43 | 13 | 37241 | 3135 | 64458343 |
Neutrophil count decreased | 14.38 | 11.43 | 14 | 37240 | 77182 | 64384296 |
Blood calcium increased | 14.35 | 11.43 | 21 | 37233 | 8521 | 64452957 |
Coronary artery dissection | 14.31 | 11.43 | 8 | 37246 | 902 | 64460576 |
Rheumatoid arthritis | 14.21 | 11.43 | 48 | 37206 | 164246 | 64297232 |
Alopecia | 13.93 | 11.43 | 49 | 37205 | 165641 | 64295837 |
Vaccination site pain | 13.79 | 11.43 | 4 | 37250 | 78 | 64461400 |
Eosinophilic fasciitis | 13.76 | 11.43 | 5 | 37249 | 203 | 64461275 |
Arthropathy | 13.70 | 11.43 | 31 | 37223 | 120936 | 64340542 |
Blister | 13.62 | 11.43 | 16 | 37238 | 80951 | 64380527 |
Infusion related reaction | 13.59 | 11.43 | 49 | 37205 | 164418 | 64297060 |
Stoma site irritation | 13.56 | 11.43 | 5 | 37249 | 212 | 64461266 |
Sleep-related eating disorder | 13.54 | 11.43 | 7 | 37247 | 675 | 64460803 |
Hypersomnia | 13.50 | 11.43 | 33 | 37221 | 19684 | 64441794 |
Fibroma | 13.47 | 11.43 | 7 | 37247 | 682 | 64460796 |
Underdose | 13.40 | 11.43 | 39 | 37215 | 25790 | 64435688 |
Nasopharyngitis | 13.34 | 11.43 | 63 | 37191 | 196010 | 64265468 |
Depression | 13.26 | 11.43 | 163 | 37091 | 183128 | 64278350 |
Heat stroke | 13.18 | 11.43 | 9 | 37245 | 1446 | 64460032 |
Amnesia | 13.12 | 11.43 | 59 | 37195 | 48210 | 64413268 |
Speech disorder | 13.01 | 11.43 | 59 | 37195 | 48382 | 64413096 |
Inhibitory drug interaction | 12.83 | 11.43 | 13 | 37241 | 3614 | 64457864 |
Interstitial lung disease | 12.81 | 11.43 | 23 | 37231 | 97709 | 64363769 |
Anisomastia | 12.79 | 11.43 | 3 | 37251 | 24 | 64461454 |
Middle insomnia | 12.75 | 11.43 | 25 | 37229 | 12852 | 64448626 |
Abdominal discomfort | 12.74 | 11.43 | 58 | 37196 | 182264 | 64279214 |
Sexual activity increased | 12.69 | 11.43 | 3 | 37251 | 25 | 64461453 |
Irritable bowel syndrome | 12.67 | 11.43 | 3 | 37251 | 37366 | 64424112 |
Apathy | 12.60 | 11.43 | 23 | 37231 | 11209 | 64450269 |
Excessive exercise | 12.48 | 11.43 | 3 | 37251 | 27 | 64461451 |
Bladder sphincter atony | 12.46 | 11.43 | 4 | 37250 | 111 | 64461367 |
Irritability | 12.41 | 11.43 | 48 | 37206 | 36698 | 64424780 |
Motor dysfunction | 12.40 | 11.43 | 23 | 37231 | 11350 | 64450128 |
Sepsis | 12.39 | 11.43 | 80 | 37174 | 230261 | 64231217 |
Meningorrhagia | 12.37 | 11.43 | 5 | 37249 | 272 | 64461206 |
Lung hyperinflation | 12.35 | 11.43 | 9 | 37245 | 1603 | 64459875 |
Stoma site haemorrhage | 12.35 | 11.43 | 9 | 37245 | 1604 | 64459874 |
Somnambulism | 12.27 | 11.43 | 15 | 37239 | 5126 | 64456352 |
Euphoric mood | 12.25 | 11.43 | 17 | 37237 | 6574 | 64454904 |
Mobility decreased | 12.09 | 11.43 | 88 | 37166 | 85752 | 64375726 |
Hepatotoxicity | 12.08 | 11.43 | 4 | 37250 | 39958 | 64421520 |
Stoma site extravasation | 12.00 | 11.43 | 5 | 37249 | 294 | 64461184 |
Road traffic accident | 11.92 | 11.43 | 42 | 37212 | 30703 | 64430775 |
Sopor | 11.92 | 11.43 | 41 | 37213 | 29620 | 64431858 |
Hepatic enzyme increased | 11.90 | 11.43 | 37 | 37217 | 129906 | 64331572 |
Device connection issue | 11.88 | 11.43 | 7 | 37247 | 872 | 64460606 |
None
Source | Code | Description |
---|---|---|
ATC | N04BC05 | NERVOUS SYSTEM ANTI-PARKINSON DRUGS DOPAMINERGIC AGENTS Dopamine agonists |
FDA MoA | N0000000117 | Dopamine Agonists |
MeSH PA | D018726 | Anti-Dyskinesia Agents |
MeSH PA | D000975 | Antioxidants |
MeSH PA | D000978 | Antiparkinson Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D015259 | Dopamine Agents |
MeSH PA | D018491 | Dopamine Agonists |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D020011 | Protective Agents |
CHEBI has role | CHEBI:48407 | antiparkinson agent |
CHEBI has role | CHEBI:48578 | free radical scavengers |
CHEBI has role | CHEBI:51065 | Dopamine receptor agonist |
CHEBI has role | CHEBI:66956 | antidyskinetic agent |
FDA EPC | N0000175768 | Nonergot Dopamine Agonist |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Restless legs | indication | 32914008 | DOID:0050425 |
Parkinson's disease | indication | 49049000 | DOID:14330 |
Fibromyalgia | off-label use | 203082005 | DOID:631 |
Hallucinations | contraindication | 7011001 | |
Dyskinesia | contraindication | 9748009 | |
Orthostatic hypotension | contraindication | 28651003 | |
Narcolepsy | contraindication | 60380001 | DOID:8986 |
Psychotic disorder | contraindication | 69322001 | |
Sleep apnea | contraindication | 73430006 | DOID:0050847 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Drowsy | contraindication | 271782001 | |
Malignant melanoma | contraindication | 372244006 | |
Breastfeeding (mother) | contraindication | 413712001 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.57 | Basic |
pKa2 | 5.18 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
0.375MG | MIRAPEX ER | BOEHRINGER INGELHEIM | N022421 | Feb. 19, 2010 | RX | TABLET, EXTENDED RELEASE | ORAL | 8679533 | Sept. 8, 2029 | TREATMENT OF PARKINSONS DISEASE |
0.75MG | MIRAPEX ER | BOEHRINGER INGELHEIM | N022421 | Feb. 19, 2010 | RX | TABLET, EXTENDED RELEASE | ORAL | 8679533 | Sept. 8, 2029 | TREATMENT OF PARKINSONS DISEASE |
1.5MG | MIRAPEX ER | BOEHRINGER INGELHEIM | N022421 | Feb. 19, 2010 | RX | TABLET, EXTENDED RELEASE | ORAL | 8679533 | Sept. 8, 2029 | TREATMENT OF PARKINSONS DISEASE |
2.25MG | MIRAPEX ER | BOEHRINGER INGELHEIM | N022421 | June 17, 2011 | RX | TABLET, EXTENDED RELEASE | ORAL | 8679533 | Sept. 8, 2029 | TREATMENT OF PARKINSONS DISEASE |
3.75MG | MIRAPEX ER | BOEHRINGER INGELHEIM | N022421 | June 17, 2011 | RX | TABLET, EXTENDED RELEASE | ORAL | 8679533 | Sept. 8, 2029 | TREATMENT OF PARKINSONS DISEASE |
3MG | MIRAPEX ER | BOEHRINGER INGELHEIM | N022421 | Feb. 19, 2010 | RX | TABLET, EXTENDED RELEASE | ORAL | 8679533 | Sept. 8, 2029 | TREATMENT OF PARKINSONS DISEASE |
4.5MG | MIRAPEX ER | BOEHRINGER INGELHEIM | N022421 | Feb. 19, 2010 | RX | TABLET, EXTENDED RELEASE | ORAL | 8679533 | Sept. 8, 2029 | TREATMENT OF PARKINSONS DISEASE |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
D(2) dopamine receptor | GPCR | AGONIST | EC50 | 6.60 | WOMBAT-PK | CHEMBL | |||
Beta-2 adrenergic receptor | GPCR | Ki | 4 | CHEMBL | |||||
Alpha-2A adrenergic receptor | GPCR | Ki | 7.12 | PDSP | |||||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 6.16 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 2A | GPCR | EC50 | 5.93 | CHEMBL | |||||
5-hydroxytryptamine receptor 7 | GPCR | Ki | 5.93 | PDSP | |||||
Alpha-2B adrenergic receptor | GPCR | Ki | 6.20 | WOMBAT-PK | |||||
D(3) dopamine receptor | GPCR | AGONIST | EC50 | 8.67 | WOMBAT-PK | ||||
Histamine H2 receptor | GPCR | Ki | 5.57 | PDSP | |||||
5-hydroxytryptamine receptor 1B | GPCR | Ki | 5.46 | PDSP | |||||
5-hydroxytryptamine receptor 1D | GPCR | Ki | 5.78 | PDSP | |||||
Alpha-2C adrenergic receptor | GPCR | Ki | 7.28 | PDSP | |||||
D(4) dopamine receptor | GPCR | AGONIST | Ki | 9.31 | CHEMBL | ||||
D(2) dopamine receptor | GPCR | Ki | 8.51 | CHEMBL | |||||
D(2) dopamine receptor | GPCR | Kd | 8.80 | CHEMBL | |||||
D(3) dopamine receptor | GPCR | Ki | 9.35 | CHEMBL |
ID | Source |
---|---|
4024071 | VUID |
N0000022076 | NUI |
D00559 | KEGG_DRUG |
191217-81-9 | SECONDARY_CAS_RN |
4021042 | VANDF |
4024071 | VANDF |
C0074710 | UMLSCUI |
CHEBI:8356 | CHEBI |
G6L | PDB_CHEM_ID |
CHEMBL301265 | ChEMBL_ID |
DB00413 | DRUGBANK_ID |
CHEMBL3182733 | ChEMBL_ID |
CHEMBL542257 | ChEMBL_ID |
D000077487 | MESH_DESCRIPTOR_UI |
119570 | PUBCHEM_CID |
6227 | INN_ID |
953 | IUPHAR_LIGAND_ID |
83619PEU5T | UNII |
236747 | RXNORM |
169631 | MMSL |
23370 | MMSL |
5340 | MMSL |
d04145 | MMSL |
006721 | NDDF |
006722 | NDDF |
108471007 | SNOMEDCT_US |
386852009 | SNOMEDCT_US |
412282004 | SNOMEDCT_US |
725650009 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Mirapex ER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0109 | TABLET, EXTENDED RELEASE | 0.38 mg | ORAL | NDA | 32 sections |
Mirapex ER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0113 | TABLET, EXTENDED RELEASE | 1.50 mg | ORAL | NDA | 32 sections |
Mirapex ER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0115 | TABLET, EXTENDED RELEASE | 3 mg | ORAL | NDA | 32 sections |
Mirapex ER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0116 | TABLET, EXTENDED RELEASE | 4.50 mg | ORAL | NDA | 32 sections |
Mirapex ER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0285 | TABLET, EXTENDED RELEASE | 0.75 mg | ORAL | NDA | 32 sections |
Mirapex ER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0286 | TABLET, EXTENDED RELEASE | 2.25 mg | ORAL | NDA | 32 sections |
Mirapex ER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0597-0287 | TABLET, EXTENDED RELEASE | 3.75 mg | ORAL | NDA | 32 sections |
Pramipexole Dihydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-7597 | TABLET | 1 mg | ORAL | ANDA | 28 sections |
Pramipexole Dihydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6704 | TABLET | 0.25 mg | ORAL | ANDA | 20 sections |
Pramipexole Dihydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6704 | TABLET | 0.25 mg | ORAL | ANDA | 20 sections |
Pramipexole DihydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-251 | TABLET, EXTENDED RELEASE | 0.38 mg | ORAL | ANDA | 28 sections |
Pramipexole DihydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-251 | TABLET, EXTENDED RELEASE | 0.38 mg | ORAL | ANDA | 28 sections |
Pramipexole DihydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-252 | TABLET, EXTENDED RELEASE | 0.75 mg | ORAL | ANDA | 28 sections |
Pramipexole DihydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-252 | TABLET, EXTENDED RELEASE | 0.75 mg | ORAL | ANDA | 28 sections |
Pramipexole DihydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-253 | TABLET, EXTENDED RELEASE | 1.50 mg | ORAL | ANDA | 28 sections |
Pramipexole DihydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-253 | TABLET, EXTENDED RELEASE | 1.50 mg | ORAL | ANDA | 28 sections |
Pramipexole DihydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-254 | TABLET, EXTENDED RELEASE | 3 mg | ORAL | ANDA | 28 sections |
Pramipexole DihydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-254 | TABLET, EXTENDED RELEASE | 3 mg | ORAL | ANDA | 28 sections |
Pramipexole DihydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-255 | TABLET, EXTENDED RELEASE | 4.50 mg | ORAL | ANDA | 28 sections |
Pramipexole DihydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-255 | TABLET, EXTENDED RELEASE | 4.50 mg | ORAL | ANDA | 28 sections |
Pramipexole DihydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-305 | TABLET, EXTENDED RELEASE | 2.25 mg | ORAL | ANDA | 28 sections |
Pramipexole DihydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-305 | TABLET, EXTENDED RELEASE | 2.25 mg | ORAL | ANDA | 28 sections |
Pramipexole DihydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-306 | TABLET, EXTENDED RELEASE | 3.75 mg | ORAL | ANDA | 28 sections |
Pramipexole DihydrochlorideExtended-Release | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10370-306 | TABLET, EXTENDED RELEASE | 3.75 mg | ORAL | ANDA | 28 sections |
Pramipexole Dihydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-091 | TABLET | 0.13 mg | ORAL | ANDA | 20 sections |
Pramipexole Dihydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-091 | TABLET | 0.13 mg | ORAL | ANDA | 20 sections |
Pramipexole Dihydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-092 | TABLET | 0.25 mg | ORAL | ANDA | 20 sections |
Pramipexole Dihydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-092 | TABLET | 0.25 mg | ORAL | ANDA | 20 sections |
Pramipexole Dihydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-093 | TABLET | 0.50 mg | ORAL | ANDA | 20 sections |
Pramipexole Dihydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-093 | TABLET | 0.50 mg | ORAL | ANDA | 20 sections |