polysorbate 80 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2227	9005-65-6

Description:

Molecule	Description
Synonyms: polysorbate 80 polyethoxylated sorbitan monooleate	Sorbitan mono-9-octadecanoate poly(oxy-1,2-ethanediyl) derivatives; complex mixtures of polyoxyethylene ethers used as emulsifiers or dispersing agents in pharmaceuticals. Molecular weight: Formula: C24H44O6(C2H4O)x(C2H4O)w(C2H4O)y(C2H4O)z CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: ALOGS: ROTB: None

Molecule

Description

Synonyms:

polysorbate 80
polyethoxylated sorbitan monooleate

Sorbitan mono-9-octadecanoate poly(oxy-1,2-ethanediyl) derivatives; complex mixtures of polyoxyethylene ethers used as emulsifiers or dispersing agents in pharmaceuticals.

Molecular weight:
Formula: C24H44O6(C2H4O)x(C2H4O)w(C2H4O)y(C2H4O)z
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA:
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D005079	Excipients
MeSH PA	D010592	Pharmaceutic Aids
MeSH PA	D014677	Pharmaceutical Vehicles
MeSH PA	D013501	Surface-Active Agents
CHEBI has role	CHEBI:38828	non-ionic surfactant

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Tear film insufficiency	indication	46152009
Keratoconjunctivitis sicca	off-label use	302896008	DOID:12895

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4017948	VUID
N0000178958	NUI
D01067	KEGG_DRUG
4017948	VANDF
C0032601	UMLSCUI
CHEBI:53426	CHEBI
VCG	PDB_CHEM_ID
CHEMBL1697847	ChEMBL_ID
D011136	MESH_DESCRIPTOR_UI
DB11063	DRUGBANK_ID
6OZP39ZG8H	UNII
8560	RXNORM
NOCODE	MMSL
009865	NDDF
255899003	SNOMEDCT_US
411257002	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
REFRESH OPTIVE Advanced	HUMAN OTC DRUG LABEL	3	0023-4307	SOLUTION/ DROPS	5 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	12 sections
REFRESH OPTIVE Advanced	HUMAN OTC DRUG LABEL	3	0023-4307	SOLUTION/ DROPS	5 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	12 sections
REFRESH OPTIVE Advanced	HUMAN OTC DRUG LABEL	3	0023-4491	SOLUTION/ DROPS	5 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	11 sections
REFRESH OPTIVE Advanced	HUMAN OTC DRUG LABEL	3	0023-4491	SOLUTION/ DROPS	5 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	11 sections
REFRESH OPTIVE Mega-3	HUMAN OTC DRUG LABEL	3	0023-5773	SOLUTION/ DROPS	5 mg	OPHTHALMIC	OTC monograph final	10 sections
REFRESH OPTIVE Mega-3	HUMAN OTC DRUG LABEL	3	0023-5773	SOLUTION/ DROPS	5 mg	OPHTHALMIC	OTC monograph final	10 sections
Refresh Digital	HUMAN OTC DRUG LABEL	3	0023-6952	SOLUTION/ DROPS	5 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	11 sections
Refresh Digital	HUMAN OTC DRUG LABEL	3	0023-6952	SOLUTION/ DROPS	5 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	11 sections
Refresh Digital PF	HUMAN OTC DRUG LABEL	3	0023-6954	SOLUTION/ DROPS	5 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	10 sections
Refresh Digital PF	HUMAN OTC DRUG LABEL	3	0023-6954	SOLUTION/ DROPS	5 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	10 sections
REFRESH OPTIVE Mega-3	HUMAN OTC DRUG LABEL	3	0023-7151	SOLUTION/ DROPS	5 mg	OPHTHALMIC	OTC monograph final	10 sections
REFRESH OPTIVE Mega-3	HUMAN OTC DRUG LABEL	3	0023-7151	SOLUTION/ DROPS	5 mg	OPHTHALMIC	OTC monograph final	10 sections
Endura	HUMAN PRESCRIPTION DRUG LABEL	2	0023-9235	SOLUTION/ DROPS	1 g	OPHTHALMIC	Export only	1 sections
Endura	HUMAN PRESCRIPTION DRUG LABEL	2	0023-9235	SOLUTION/ DROPS	1 g	OPHTHALMIC	Export only	1 sections
IV Solution Stabilizer	HUMAN PRESCRIPTION DRUG LABEL	1	0310-4715	SOLUTION	6.50 mg	INTRAVENOUS	BLA	28 sections
IV Solution Stabilizer	HUMAN PRESCRIPTION DRUG LABEL	1	0310-4715	SOLUTION	6.50 mg	INTRAVENOUS	BLA	28 sections
RohtoCool Relief	HUMAN OTC DRUG LABEL	2	10742-8141	LIQUID	2 mg	OPHTHALMIC	OTC monograph final	12 sections
RohtoCool Relief	HUMAN OTC DRUG LABEL	2	10742-8141	LIQUID	2 mg	OPHTHALMIC	OTC monograph final	12 sections
RohtoCool	HUMAN OTC DRUG LABEL	2	10742-8142	LIQUID	2 mg	OPHTHALMIC	OTC monograph final	12 sections
RohtoCool	HUMAN OTC DRUG LABEL	2	10742-8142	LIQUID	2 mg	OPHTHALMIC	OTC monograph final	12 sections
Rohto Beauty Secret	HUMAN OTC DRUG LABEL	2	10742-8145	LIQUID	2 mg	OPHTHALMIC	OTC monograph final	12 sections
RohtoMax Strength	HUMAN OTC DRUG LABEL	2	10742-8158	LIQUID	2 mg	OPHTHALMIC	OTC monograph final	12 sections
RohtoMax Strength	HUMAN OTC DRUG LABEL	2	10742-8158	LIQUID	2 mg	OPHTHALMIC	OTC monograph final	12 sections
RohtoCool Max	HUMAN OTC DRUG LABEL	2	10742-8159	LIQUID	2 mg	OPHTHALMIC	OTC monograph final	12 sections
RohtoCool Max	HUMAN OTC DRUG LABEL	2	10742-8159	LIQUID	2 mg	OPHTHALMIC	OTC monograph final	12 sections
Avitears	HUMAN OTC DRUG LABEL	1	49869-002	SOLUTION/ DROPS	10 mg	TOPICAL	OTC monograph final	18 sections
Viva	HUMAN OTC DRUG LABEL	1	54891-001	SOLUTION/ DROPS	100 mg	OPHTHALMIC	OTC monograph final	8 sections
Clear Eyes Complete 7 Symptom Relief	HUMAN OTC DRUG LABEL	4	67172-595	LIQUID	1.25 mL	OPHTHALMIC	OTC MONOGRAPH FINAL	28 sections
Clear Eyes Complete 7 Sympton Relief	HUMAN OTC DRUG LABEL	4	67172-707	LIQUID	1.25 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	15 sections
Clear Eyes Complete 7 Sympton Relief	HUMAN OTC DRUG LABEL	4	67172-707	LIQUID	1.25 mg	OPHTHALMIC	OTC MONOGRAPH FINAL	15 sections