poldine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
2226 596-50-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • poldine metilsulfate
  • poldine methylsulfate
  • poldine methylsulphate
  • poldine
major descriptor (66-86); on-line search BENZILATES (66-86); INDEX MEDICUS search POLDINE (66-86); RN given refers to parent cpd
  • Molecular weight: 340.44
  • Formula: C21H26NO3
  • CLOGP: 0.22
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 46.53
  • ALOGS: -5.85
  • ROTB: 6

Drug dosage:

DoseUnitRoute
12 mg O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAP3K7,MAPK7,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,TEK,TGFBR1 23
kinase-selectivity-class AXL,GRK2,PDK4 3
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A03AB11 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
Synthetic anticholinergics, quaternary ammonium compounds

Related Drugs by ATC class:

A03AB Synthetic anticholinergics, quaternary ammonium compounds 19 drugs
(2-benzhydryloxyethyl)diethyl-methylammonium iodidebenziloniumbevoniumdiphemanilfenpiveriniumglycopyrronium bromidehexocycliumisopropamidemepenzolatemethantheliniumotilonium bromideoxyphenonium show all 19 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.54 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D05535 KEGG_DRUG
545-80-2 SECONDARY_CAS_RN
C0071324 UMLSCUI
CHEBI:135443 CHEBI
CHEMBL2110948 ChEMBL_ID
CHEMBL2106739 ChEMBL_ID
DB13507 DRUGBANK_ID
C100295 MESH_SUPPLEMENTAL_RECORD_UI
11018 PUBCHEM_CID
C030725 MESH_SUPPLEMENTAL_RECORD_UI
8R92106W2F UNII
33926 RXNORM
001743 NDDF
004699 NDDF
111129004 SNOMEDCT_US
386985000 SNOMEDCT_US
858 INN_ID

Pharmaceutical products:

None