plicamycin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, produced by Streptomyces strains 2223 18378-89-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mithramycin
  • mithramycinum
  • plicamycin
  • aureolic acid
  • mithracin
  • Mithramycin A
  • mitramycin
  • plicatomycin
A tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. It is used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors. Plicamycin is also used to reduce hypercalcemia, especially that due to malignancies.
  • Molecular weight: 1085.16
  • Formula: C52H76O24
  • CLOGP: -3.08
  • LIPINSKI: 3
  • HAC: 24
  • HDO: 11
  • TPSA: 358.20
  • ALOGS: -2.92
  • ROTB: 15
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Drug Use | Suggest Off label Use Form| |View source of the data|




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

Pharmaceutical products:

None

plicamycin