piroxicam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory, isoxicam derivatives 2210 36322-90-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • piroxicam olamine
  • piroxicam betadex
  • brexicam
  • brexidol
  • brexin
  • cicladol
  • piroxicam-beta-cyclodextrin complex
  • piroxicam beta-cyclodextrin
  • feldene
  • CP16171
  • CP-16171
  • piroxicam
A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily.
  • Molecular weight: 331.35
  • Formula: C15H13N3O4S
  • CLOGP: 1.89
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 99.60
  • ALOGS: -3.37
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O
20 mg P
20 mg R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.02 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 5 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.51 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -0.156 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 2.270 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 85.507 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 4.487 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 6.900 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 8.110 % High 1
herg hERG pIC50 3.959 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 2.825 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 3.443 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 0.820 % High 1
kinase-safety-class ACVR2A,ACVR2B,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK1,JAK2,KIT,MAP3K21,MAP3K7,MAPK7,MAPK9,MARK4,MTOR,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PIK3CG,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1 43
kinase-selectivity-class ACVR2A,ACVR2B,AURKB,AURKC,AXL,BRAF,CAMK2D,CDK9,DDR1,DYRK1B,ERBB2,GRK2,IRAK1,MAP2K6,MAPK12,MAPK7,MARK4,SIK2,STK10,STK33,TEK,TTK 22
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 6.934 High 1
mh-clint Mouse hepatocyte intrinsic clearance 7.379 High 1
mppb Mouse plasma protein binding (% unbound) 10.340 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.294 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
pppb Pig plasma protein binding (% unbound) 5.050 % High 1
rat-kpuu-brain Rat brain Kpuu 0.469 % Moderate 0.67
rh-clint Rat hepatocyte intrinsic clearance 3.214 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 94.550 % High 1
rppb Rat plasma protein binding (% unbound) 1.590 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 887.156 uM High 1

Approvals:

DateAgencyCompanyOrphan
April 6, 1982 FDA PFIZER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sciatica 689.07 19.77 569 62786 100813 90464279
Deep vein thrombosis postoperative 373.09 19.77 344 63011 70465 90494627
Psoriatic arthropathy 347.68 19.77 594 62761 227741 90337351
Autoimmune disorder 318.29 19.77 327 63028 76417 90488675
Lower limb fracture 311.32 19.77 339 63016 84674 90480418
C-reactive protein abnormal 292.12 19.77 401 62954 127028 90438064
Drug hypersensitivity 275.71 19.77 829 62526 462780 90102312
Swollen joint count increased 259.46 19.77 353 63002 110853 90454239
Road traffic accident 254.69 19.77 344 63011 107282 90457810
Rheumatic fever 237.67 19.77 402 62953 152719 90412373
Liver disorder 217.53 19.77 340 63015 120929 90444163
C-reactive protein 210.60 19.77 175 63180 31192 90533900
Lip dry 202.23 19.77 298 63057 100657 90464435
X-ray abnormal 201.88 19.77 201 63154 45223 90519869
Rheumatoid factor positive 201.02 19.77 399 62956 171251 90393841
Sinusitis 186.45 19.77 595 62760 342493 90222599
Oedema 183.11 19.77 421 62934 199874 90365218
Blood cholesterol increased 171.49 19.77 420 62935 207592 90357500
Rheumatoid arthritis 170.54 19.77 599 62756 362015 90203077
Liver injury 167.58 19.77 369 62986 170198 90394894
Mobility decreased 160.72 19.77 461 62894 250273 90314819
Adjustment disorder with depressed mood 160.17 19.77 198 63157 56555 90508537
Lupus vulgaris 158.48 19.77 176 63179 44883 90520209
Sleep disorder due to general medical condition, insomnia type 157.70 19.77 305 63050 128389 90436703
Duodenal ulcer perforation 156.76 19.77 422 62933 220866 90344226
Bursitis 151.63 19.77 304 63051 131350 90433742
Fall 151.22 19.77 74 63281 481736 90083356
Night sweats 150.30 19.77 299 63056 128467 90436625
Death 149.65 19.77 66 63289 456485 90108607
Cough 149.47 19.77 37 63318 368925 90196167
Blood iron abnormal 148.33 19.77 67 63288 3953 90561139
Fibromyalgia 145.72 19.77 393 62962 205876 90359216
Porphyria acute 145.65 19.77 112 63243 17863 90547229
Type 2 diabetes mellitus 144.35 19.77 388 62967 202856 90362236
Musculoskeletal pain 141.34 19.77 346 63009 170905 90394187
Dry mouth 139.48 19.77 360 62995 183699 90381393
Acute kidney injury 131.96 19.77 31 63324 320356 90244736
Obesity 131.63 19.77 252 63103 105255 90459837
Grip strength 130.05 19.77 80 63275 8885 90556207
Drug ineffective 128.87 19.77 516 62839 1383782 89181310
Product dose omission issue 128.81 19.77 24 63331 291663 90273429
Prescribed overdose 127.77 19.77 238 63117 97387 90467705
Muscle injury 127.19 19.77 339 63016 176315 90388777
Injury 126.54 19.77 363 62992 196986 90368106
Anaemia 125.40 19.77 45 63310 352757 90212335
Lung disorder 124.91 19.77 304 63051 149579 90415513
Folliculitis 124.43 19.77 369 62986 203984 90361108
Peripheral venous disease 120.50 19.77 213 63142 83708 90481384
Anti-cyclic citrullinated peptide antibody positive 119.24 19.77 400 62955 236033 90329059
Blister 116.95 19.77 418 62937 254580 90310512
Live birth 113.86 19.77 201 63154 78906 90486186
Dislocation of vertebra 111.72 19.77 165 63190 55803 90509289
Neutropenia 109.52 19.77 14 63341 224890 90340202
Discomfort 108.62 19.77 429 62926 273906 90291186
Hypotension 108.21 19.77 46 63309 325351 90239741
Breast cancer stage III 108.16 19.77 204 63151 84243 90480849
Joint range of motion decreased 107.60 19.77 270 63085 135373 90429719
Urinary tract infection 106.88 19.77 40 63315 305592 90259500
Pregnancy 105.71 19.77 170 63185 61877 90503215
Wound infection 105.35 19.77 231 63124 106171 90458921
Gait inability 105.34 19.77 281 63074 146175 90418917
Treatment failure 105.19 19.77 456 62899 303472 90261620
Pulmonary fibrosis 104.86 19.77 232 63123 107271 90457821
Wheezing 104.69 19.77 385 62970 237695 90327397
Helicobacter infection 101.56 19.77 369 62986 226481 90338611
Osteoarthritis 95.01 19.77 327 63028 195403 90369689
Asthma 92.87 19.77 375 62980 241785 90323307
Dehydration 90.23 19.77 14 63341 194433 90370659
Irritable bowel syndrome 89.95 19.77 334 63021 207114 90357978
Hallucinations, mixed 89.13 19.77 54 63301 5835 90559257
Grip strength decreased 88.27 19.77 198 63157 92378 90472714
Retinitis 87.97 19.77 121 63234 38337 90526755
Impaired healing 86.11 19.77 358 62997 233841 90331251
Wound 85.97 19.77 429 62926 302551 90262541
Drug tolerance decreased 85.69 19.77 109 63246 32021 90533071
Musculoskeletal stiffness 85.65 19.77 422 62933 296110 90268982
Febrile neutropenia 84.46 19.77 7 63348 158342 90406750
Facet joint syndrome 83.47 19.77 201 63154 98188 90466904
Therapy non-responder 83.29 19.77 247 63108 136457 90428635
Prescribed underdose 81.31 19.77 169 63186 74850 90490242
Sepsis 81.07 19.77 14 63341 179800 90385292
Gastrointestinal disorder 80.41 19.77 374 62981 256313 90308779
Red blood cell sedimentation rate increased 80.26 19.77 178 63177 82417 90482675
Hypoaesthesia 80.21 19.77 432 62923 313778 90251314
Amnesia 79.84 19.77 210 63145 108295 90456797
Abdominal pain upper 79.32 19.77 449 62906 332225 90232867
Memory impairment 79.27 19.77 310 63045 196934 90368158
Constipation 79.25 19.77 49 63306 280346 90284746
Delirium 78.86 19.77 204 63151 104155 90460937
Drug interaction 78.57 19.77 48 63307 276405 90288687
Contusion 77.93 19.77 365 62990 250851 90314241
Respiratory disorder 76.16 19.77 151 63204 64665 90500427
Seizure 75.52 19.77 9 63346 152620 90412472
Ill-defined disorder 73.81 19.77 290 63065 184601 90380491
Hip arthroplasty 73.78 19.77 164 63191 76044 90489048
Swollen joint count 72.48 19.77 55 63300 8598 90556494
Lower respiratory tract infection 71.84 19.77 356 62999 250303 90314789
Pericarditis 71.36 19.77 375 62980 269776 90295316
Lupus-like syndrome 70.12 19.77 124 63231 48722 90516370
Injection site pain 69.15 19.77 18 63337 173681 90391411
Arthropathy 68.87 19.77 465 62890 365777 90199315
Hand deformity 68.66 19.77 397 62958 295965 90269127
Thermal burn 68.00 19.77 48 63307 6714 90558378
Pneumonia 67.46 19.77 225 63130 637834 89927258
COVID-19 66.26 19.77 18 63337 168825 90396267
Maternal exposure timing unspecified 65.93 19.77 80 63275 22403 90542689
Anxiety 64.76 19.77 404 62951 309368 90255724
Completed suicide 63.86 19.77 12 63343 145046 90420046
Decreased appetite 63.72 19.77 466 62889 376074 90189018
Stomatitis 62.98 19.77 367 62988 274331 90290761
Pleural effusion 62.44 19.77 4 63351 111987 90453105
Back pain 62.40 19.77 78 63277 317097 90247995
Bone erosion 61.66 19.77 123 63232 52898 90512194
Exostosis 61.48 19.77 123 63232 53011 90512081
Rheumatic disorder 61.44 19.77 35 63320 3373 90561719
Toxicity to various agents 60.68 19.77 67 63288 287779 90277313
Ulcer haemorrhage 60.47 19.77 83 63272 26238 90538854
Knee arthroplasty 60.18 19.77 160 63195 83022 90482070
Somnolence 59.82 19.77 36 63319 209048 90356044
Malignant neoplasm progression 59.04 19.77 4 63351 106866 90458226
Laryngitis 58.14 19.77 117 63238 50636 90514456
Drug intolerance 56.87 19.77 519 62836 447072 90118020
Anti-cyclic citrullinated peptide antibody 55.39 19.77 81 63274 27140 90537952
Hepatic cirrhosis 54.47 19.77 130 63225 63123 90501969
Respiratory failure 53.85 19.77 9 63346 118409 90446683
Tremor 53.58 19.77 20 63335 153153 90411939
Laboratory test abnormal 53.43 19.77 101 63254 41753 90523339
Sleep disorder 53.02 19.77 276 63079 197754 90367338
Chest discomfort 51.99 19.77 16 63339 138349 90426743
General physical health deterioration 51.46 19.77 424 62931 354691 90210401
Fatigue 51.35 19.77 538 62817 1153485 89411607
Multiple allergies 51.25 19.77 58 63297 15088 90550004
Synovitis 51.20 19.77 400 62955 329352 90235740
Breast cancer stage II 51.10 19.77 90 63265 35244 90529848
Atrial fibrillation 51.02 19.77 15 63340 133596 90431496
Walking aid user 50.79 19.77 90 63265 35416 90529676
Overdose 49.72 19.77 24 63331 157685 90407407
Neuropathy peripheral 49.42 19.77 17 63338 136953 90428139
Hyperhidrosis 49.03 19.77 17 63338 136288 90428804
Influenza 49.02 19.77 18 63337 139246 90425846
Laryngeal disorder 48.45 19.77 21 63334 1122 90563970
Adverse event 48.32 19.77 186 63169 117232 90447860
Cardiac failure 48.32 19.77 9 63346 109487 90455605
Chills 48.28 19.77 16 63339 131965 90433127
Sleep disorder due to a general medical condition 47.55 19.77 100 63255 44638 90520454
Myalgia 46.22 19.77 33 63322 175092 90390000
Dysphagia 45.91 19.77 11 63344 112267 90452825
Frequent bowel movements 45.81 19.77 114 63241 56821 90508271
Cerebrovascular accident 45.14 19.77 15 63340 123518 90441574
Oxygen saturation decreased 45.00 19.77 10 63345 107473 90457619
Off label use 44.58 19.77 525 62830 1101727 89463365
Pulmonary embolism 44.24 19.77 18 63337 130802 90434290
Cardiac failure congestive 43.79 19.77 8 63347 98686 90466406
Nausea 43.32 19.77 533 62822 1109783 89455309
Pancreatitis 43.30 19.77 127 63228 69699 90495393
Condition aggravated 43.17 19.77 619 62736 594926 89970166
Glossodynia 42.81 19.77 377 62978 321402 90243690
Blood pressure increased 42.55 19.77 45 63310 197172 90367920
Abdominal distension 42.52 19.77 19 63336 130582 90434510
Influenza like illness 41.79 19.77 4 63351 80607 90484485
Blood immunoglobulin M increased 41.71 19.77 20 63335 1352 90563740
Foot deformity 41.39 19.77 113 63242 59538 90505554
Nasal congestion 41.05 19.77 5 63350 83409 90481683
Neurosis 40.90 19.77 14 63341 391 90564701
Hepatic enzyme increased 40.67 19.77 408 62947 360328 90204764
Chest pain 40.22 19.77 370 62985 319275 90245817
Pemphigus 39.94 19.77 376 62979 326488 90238604
Injection site reaction 39.71 19.77 8 63347 92072 90473020
Colitis ulcerative 39.68 19.77 112 63243 60154 90504938
Intestinal diaphragm disease 39.52 19.77 11 63344 150 90564942
White blood cell count increased 39.52 19.77 120 63235 67121 90497971
Dry skin 39.37 19.77 7 63348 88066 90477026
Feeling abnormal 38.56 19.77 36 63319 167199 90397893
Confusional state 38.47 19.77 426 62929 385779 90179313
Renal failure 38.24 19.77 22 63333 130985 90434107
Palpitations 37.09 19.77 25 63330 136703 90428389
Blood immunoglobulin A decreased 37.04 19.77 20 63335 1736 90563356
Disease progression 36.95 19.77 33 63322 156582 90408510
Depressed level of consciousness 36.73 19.77 4 63351 72780 90492312
Feeling hot 36.65 19.77 129 63226 77879 90487213
Skin exfoliation 36.21 19.77 3 63352 67910 90497182
Heart rate increased 35.86 19.77 17 63338 112885 90452207
Erythema 35.78 19.77 66 63289 229180 90335912
Septic shock 34.89 19.77 8 63347 84152 90480940
Inappropriate schedule of product administration 34.89 19.77 32 63323 149901 90415191
Hallucination, auditory 34.64 19.77 49 63306 15926 90549166
Dyspnoea 34.63 19.77 422 62933 880533 89684559
Infection 33.61 19.77 394 62961 361700 90203392
Balance disorder 33.41 19.77 13 63342 97067 90468025
Ear infection 33.31 19.77 116 63239 69659 90495433
Intentional overdose 33.24 19.77 12 63343 93822 90471270
Cardio-respiratory arrest 33.09 19.77 3 63352 63137 90501955
Systemic lupus erythematosus 32.81 19.77 392 62963 361504 90203588
Pain 32.78 19.77 495 62860 995846 89569246
Chronic obstructive pulmonary disease 32.72 19.77 6 63349 73823 90491269
Oropharyngeal pain 32.70 19.77 20 63335 115167 90449925
Colitis 32.51 19.77 5 63350 69937 90495155
Electrocardiogram QT prolonged 31.87 19.77 6 63349 72450 90492642
Hypoxia 31.83 19.77 6 63349 72393 90492699
Diabetes mellitus 31.65 19.77 4 63351 64871 90500221
Hypercholesterolaemia 31.53 19.77 147 63208 100745 90464347
Therapeutic product effect decreased 31.29 19.77 314 63041 277257 90287835
Therapeutic product effect incomplete 31.05 19.77 237 63118 193659 90371433
Bradycardia 30.95 19.77 10 63345 83837 90481255
Wound complication 30.77 19.77 26 63329 4737 90560355
Hot flush 30.71 19.77 3 63352 59485 90505607
Incorrect route of product administration 30.36 19.77 91 63264 50535 90514557
Hypoglycaemia 30.26 19.77 6 63349 69842 90495250
Rhinorrhoea 30.10 19.77 12 63343 88304 90476788
White blood cell count decreased 29.90 19.77 44 63311 167065 90398027
Dyspnoea exertional 29.71 19.77 7 63348 72281 90492811
Stress 29.53 19.77 10 63345 81385 90483707
Ear pain 29.36 19.77 98 63257 57604 90507488
Hypokalaemia 29.32 19.77 29 63326 131087 90434005
Rectal haemorrhage 29.20 19.77 125 63230 82619 90482473
Productive cough 28.78 19.77 9 63346 77054 90488038
Persistent depressive disorder 28.44 19.77 15 63340 1242 90563850
Interstitial lung disease 28.40 19.77 9 63346 76396 90488696
Joint dislocation 27.55 19.77 81 63274 44501 90520591
Vision blurred 27.54 19.77 22 63333 110271 90454821
Joint swelling 27.38 19.77 499 62856 502801 90062291
Blood immunoglobulin G increased 27.37 19.77 20 63335 2952 90562140
Weight fluctuation 26.89 19.77 49 63306 19700 90545392
Fluid retention 26.86 19.77 14 63341 88077 90477015
Drug abuse 26.77 19.77 12 63343 82335 90482757
Epistaxis 26.75 19.77 13 63342 85112 90479980
Blood pressure fluctuation 26.14 19.77 3 63352 52410 90512682
Suicide attempt 26.10 19.77 10 63345 75389 90489703
Platelet count decreased 25.56 19.77 35 63320 136934 90428158
Rash erythematous 25.42 19.77 7 63348 65097 90499995
Quadriparesis 25.41 19.77 18 63337 2531 90562561
Pancytopenia 25.31 19.77 28 63327 120235 90444857
Swelling 25.11 19.77 422 62933 418636 90146456
Adverse drug reaction 24.83 19.77 153 63202 116548 90448544
Syncope 24.65 19.77 34 63321 132629 90432463
Lethargy 24.26 19.77 7 63348 63132 90501960
Myocardial infarction 24.20 19.77 23 63332 105949 90459143
Urticaria 24.19 19.77 329 63026 312405 90252687
Gastrooesophageal reflux disease 24.12 19.77 50 63305 166287 90398805
Hallucination 24.11 19.77 8 63347 65951 90499141
Hyponatraemia 24.04 19.77 35 63320 133503 90431589
Cardiac arrest 23.70 19.77 23 63332 104912 90460180
Weight increased 23.65 19.77 417 62938 417510 90147582
Suicidal ideation 23.63 19.77 11 63344 73844 90491248
Illness 23.59 19.77 14 63341 81955 90483137
Bone pain 23.58 19.77 7 63348 61976 90503116
Incorrect dose administered 23.40 19.77 13 63342 78917 90486175
Ascites 23.15 19.77 3 63352 47737 90517355
Blood potassium decreased 23.15 19.77 3 63352 47724 90517368
Rhabdomyolysis 23.07 19.77 4 63351 51252 90513840
Dry eye 23.05 19.77 6 63349 57925 90507167
Flushing 22.92 19.77 17 63338 88474 90476618
Eye injury 22.72 19.77 33 63322 10987 90554105
Pachymeningitis 22.37 19.77 8 63347 255 90564837
Hypertension 22.26 19.77 446 62909 457086 90108006
Arrhythmogenic right ventricular dysplasia 22.07 19.77 5 63350 27 90565065
Inflammation 22.06 19.77 206 63149 178386 90386706
Deep vein thrombosis 21.98 19.77 19 63336 91601 90473491
Injection site erythema 21.77 19.77 22 63333 98480 90466612
Injection site bruising 21.63 19.77 5 63350 52302 90512790
Surgery 21.34 19.77 3 63352 44884 90520208
Gastrointestinal haemorrhage 21.30 19.77 19 63336 90229 90474863
Hypertransaminasaemia 21.21 19.77 39 63316 15786 90549306
Neoplasm progression 21.09 19.77 3 63352 44483 90520609
Muscular weakness 21.01 19.77 229 63126 206437 90358655
Pneumonitis 20.89 19.77 3 63352 44167 90520925
Dysphonia 20.81 19.77 9 63346 63075 90502017
Cellulitis 20.65 19.77 20 63335 91317 90473775
Cardiac disorder 20.61 19.77 7 63348 56865 90508227
Swelling face 20.59 19.77 16 63339 81336 90483756
Breast cancer 20.58 19.77 6 63349 53755 90511337
Aspartate aminotransferase increased 20.55 19.77 25 63330 102912 90462180
Lactic acidosis 20.52 19.77 5 63350 50458 90514634
Respiratory tract infection 20.18 19.77 8 63347 59070 90506022
Encephalopathy 20.10 19.77 4 63351 46440 90518652
Red blood cell count decreased 20.04 19.77 4 63351 46347 90518745
Haemoglobin decreased 20.02 19.77 53 63302 161903 90403189
Hepatic function abnormal 20.00 19.77 4 63351 46284 90518808
Vertigo 19.98 19.77 12 63343 69799 90495293

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Osteopenia 70.82 17.72 26 4355 6252 42610702
Sacroiliitis 49.71 17.72 15 4366 1967 42614987
Palmoplantar pustulosis 48.20 17.72 11 4370 484 42616470
Drug hypersensitivity 48.03 17.72 55 4326 99334 42517620
Mast cell activation syndrome 46.67 17.72 10 4371 328 42616626
Secondary hypogonadism 43.15 17.72 11 4370 775 42616179
Fixed eruption 42.50 17.72 14 4367 2440 42614514
Chest expansion decreased 41.88 17.72 8 4373 145 42616809
Inflammatory pain 41.38 17.72 10 4371 565 42616389
Ankylosing spondylitis 40.57 17.72 18 4363 7038 42609916
Angioedema 40.25 17.72 34 4347 42443 42574511
Benign abdominal neoplasm 38.97 17.72 7 4374 89 42616865
Urticaria 34.11 17.72 40 4341 73996 42542958
Enthesopathy 33.27 17.72 14 4367 4814 42612140
Joint range of motion decreased 32.82 17.72 16 4365 7737 42609217
Spondylitis 31.45 17.72 10 4371 1558 42615396
Polychondritis 29.10 17.72 7 4374 388 42616566
Plantar fasciitis 28.39 17.72 11 4370 3059 42613895
Acute generalised exanthematous pustulosis 28.39 17.72 15 4366 8580 42608374
Tendon operation 27.38 17.72 5 4376 70 42616884
Arthralgia 27.22 17.72 63 4318 205175 42411779
Axial spondyloarthritis 26.86 17.72 7 4374 538 42616416
Cross sensitivity reaction 26.79 17.72 9 4372 1666 42615288
Drug interaction 24.15 17.72 71 4310 266928 42350026
Suicidal ideation 23.81 17.72 27 4354 48134 42568820
Duodenal ulcer 23.41 17.72 15 4366 12264 42604690
Oral pruritus 22.22 17.72 6 4375 528 42616426
Brain hypoxia 21.18 17.72 6 4375 631 42616323
Adrenoleukodystrophy 21.02 17.72 4 4377 71 42616883
Depression 20.34 17.72 39 4342 111324 42505630
Vitreous haemorrhage 19.04 17.72 8 4373 2739 42614215
Death 18.48 17.72 13 4368 471172 42145782
Laziness 18.36 17.72 5 4376 455 42616499
Anaphylactic reaction 17.87 17.72 22 4359 42721 42574233
Abscess oral 17.85 17.72 5 4376 505 42616449

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sciatica 681.34 21.85 504 63553 91895 110433347
Deep vein thrombosis postoperative 463.09 21.85 335 63722 58956 110466286
Psoriatic arthropathy 418.56 21.85 542 63515 196219 110329023
Autoimmune disorder 403.12 21.85 321 63736 65162 110460080
Lower limb fracture 387.98 21.85 333 63724 75015 110450227
Swollen joint count increased 383.29 21.85 346 63711 83315 110441927
Rheumatic fever 351.28 21.85 393 63664 122186 110403056
C-reactive protein abnormal 329.89 21.85 391 63666 129304 110395938
Rheumatoid factor positive 318.65 21.85 387 63670 131253 110393989
Road traffic accident 285.08 21.85 331 63726 107067 110418175
Drug hypersensitivity 280.95 21.85 731 63326 453359 110071883
Duodenal ulcer perforation 272.91 21.85 419 63638 177281 110347961
Rheumatoid arthritis 269.58 21.85 559 63498 299054 110226188
X-ray abnormal 267.49 21.85 202 63855 37915 110487327
Blood cholesterol increased 251.09 21.85 412 63645 184373 110340869
Sinusitis 244.31 21.85 534 63523 296154 110229088
Liver injury 241.32 21.85 362 63695 150051 110375191
Adjustment disorder with depressed mood 238.23 21.85 200 63857 43683 110481559
Lip dry 235.27 21.85 290 63767 99793 110425449
Lupus vulgaris 234.30 21.85 178 63879 33705 110491537
Mobility decreased 232.55 21.85 459 63598 236963 110288279
Anti-cyclic citrullinated peptide antibody positive 231.55 21.85 394 63663 181590 110343652
C-reactive protein 231.33 21.85 169 63888 30162 110495080
Fibromyalgia 230.75 21.85 380 63677 170529 110354713
Sleep disorder due to general medical condition, insomnia type 229.07 21.85 294 63763 105349 110419893
Discomfort 227.29 21.85 429 63628 214278 110310964
Oedema 222.83 21.85 420 63637 209556 110315686
Acute kidney injury 221.06 21.85 49 64008 635381 109889861
Type 2 diabetes mellitus 220.59 21.85 380 63677 176852 110348390
Liver disorder 214.97 21.85 333 63724 141910 110383332
Muscle injury 214.71 21.85 331 63726 140476 110384766
Folliculitis 211.98 21.85 362 63695 167291 110357951
Death 205.92 21.85 74 63983 698795 109826447
Injury 193.56 21.85 359 63698 176906 110348336
Blister 192.49 21.85 414 63643 226962 110298280
Bursitis 190.53 21.85 300 63757 129618 110395624
Helicobacter infection 189.47 21.85 361 63696 181516 110343726
Prescribed overdose 184 21.85 240 63817 87341 110437901
Anaemia 178.86 21.85 48 64009 547038 109978204
Joint range of motion decreased 178.19 21.85 281 63776 121551 110403691
Night sweats 176.89 21.85 295 63762 133688 110391554
Hand deformity 176.01 21.85 390 63667 218116 110307126
Dislocation of vertebra 171.59 21.85 166 63891 43555 110481687
Wound 166.31 21.85 398 63659 234039 110291203
Irritable bowel syndrome 166.18 21.85 322 63735 163893 110361349
Hypotension 163.78 21.85 50 64007 523799 110001443
Pemphigus 160.59 21.85 372 63685 214198 110311044
Arthropathy 160.50 21.85 446 63611 287076 110238166
Porphyria acute 160.12 21.85 112 63945 18668 110506574
Neutropenia 159.59 21.85 16 64041 374604 110150638
Musculoskeletal pain 156.86 21.85 335 63722 182688 110342554
Dry mouth 156.66 21.85 353 63704 199595 110325647
Fall 156.65 21.85 77 63980 603405 109921837
Wound infection 152.97 21.85 231 63826 96234 110429008
Impaired healing 152.68 21.85 346 63711 196371 110328871
Breast cancer stage III 151.15 21.85 207 63850 78910 110446332
Pericarditis 151.12 21.85 368 63689 218746 110306496
Peripheral venous disease 150.14 21.85 213 63844 83904 110441338
Live birth 149.99 21.85 193 63864 69291 110455951
Pulmonary fibrosis 148.71 21.85 235 63822 101807 110423435
Musculoskeletal stiffness 146.35 21.85 424 63633 279398 110245844
Glossodynia 145.87 21.85 366 63691 221638 110303604
Pregnancy 144.91 21.85 163 63894 50904 110474338
Gait inability 143.60 21.85 272 63785 136104 110389138
Obesity 143.53 21.85 245 63812 113106 110412136
Cough 140.82 21.85 46 64011 461595 110063647
Gastrointestinal disorder 140.64 21.85 381 63676 241571 110283671
Grip strength 139.85 21.85 79 63978 9062 110516180
Contusion 137.17 21.85 369 63688 232992 110292250
Sepsis 136.79 21.85 15 64042 327331 110197911
Treatment failure 136.33 21.85 411 63646 276823 110248419
Grip strength decreased 135.74 21.85 198 63859 79976 110445266
Osteoarthritis 134.85 21.85 315 63742 182308 110342934
Febrile neutropenia 131.14 21.85 15 64042 316752 110208490
Systemic lupus erythematosus 130.68 21.85 383 63674 253955 110271287
Ill-defined disorder 129.69 21.85 283 63774 156570 110368672
Blood iron abnormal 129.46 21.85 44 64013 1460 110523782
Hip arthroplasty 128.33 21.85 160 63897 55653 110469589
Retinitis 125.46 21.85 122 63935 32205 110493037
Prescribed underdose 125.21 21.85 171 63886 65003 110460239
Hypoaesthesia 123.91 21.85 432 63625 313791 110211451
Lung disorder 122.64 21.85 301 63756 179746 110345496
Wheezing 122.30 21.85 375 63682 254855 110270387
Asthma 120.16 21.85 368 63689 249923 110275319
Synovitis 118.79 21.85 389 63668 273703 110251539
Drug tolerance decreased 116.49 21.85 109 63948 27431 110497811
Amnesia 115.64 21.85 214 63843 105194 110420048
Lower respiratory tract infection 113.51 21.85 354 63703 242752 110282490
Facet joint syndrome 109.26 21.85 199 63858 96629 110428613
Lupus-like syndrome 108.62 21.85 126 63931 40666 110484576
Drug ineffective 105.82 21.85 488 63569 1520052 109005190
Abdominal pain upper 105.51 21.85 441 63616 348670 110176572
Product dose omission issue 103.63 21.85 29 64028 321753 110203489
Toxicity to various agents 101.44 21.85 78 63979 480477 110044765
Knee arthroplasty 100.78 21.85 154 63903 64794 110460448
Dehydration 96.14 21.85 22 64035 279489 110245753
Stomatitis 93.36 21.85 356 63701 269886 110255356
Respiratory failure 92.17 21.85 9 64048 215323 110309919
Hepatic enzyme increased 92.03 21.85 399 63658 320493 110204749
Therapy non-responder 91.63 21.85 248 63809 157059 110368183
Alopecia 91.54 21.85 436 63621 364317 110160925
Laryngitis 90.25 21.85 117 63940 42294 110482948
Anti-cyclic citrullinated peptide antibody 90.23 21.85 82 63975 19882 110505360
Bone erosion 89.57 21.85 122 63935 46249 110478993
Memory impairment 89.34 21.85 284 63773 196660 110328582
Ulcer haemorrhage 89.12 21.85 86 63971 22485 110502757
Off label use 88.74 21.85 509 63548 1499676 109025566
Joint swelling 88.03 21.85 496 63561 442349 110082893
Sleep disorder 87.88 21.85 284 63773 198360 110326882
Atrial fibrillation 87.61 21.85 14 64043 229628 110295614
Exostosis 87.39 21.85 120 63937 45836 110479406
Urinary tract infection 87.05 21.85 40 64017 326242 110199000
Constipation 86.34 21.85 50 64007 357736 110167506
Breast cancer stage II 85.66 21.85 92 63965 27283 110497959
Pneumonia 85.53 21.85 244 63813 876470 109648772
Seizure 85.48 21.85 13 64044 221172 110304070
Walking aid user 85.10 21.85 88 63969 24987 110500255
Swelling 84.76 21.85 415 63642 350626 110174616
Respiratory disorder 84.74 21.85 150 63907 71232 110454010
Red blood cell sedimentation rate increased 83.40 21.85 157 63900 78145 110447097
Drug intolerance 82.56 21.85 458 63599 406054 110119188
Malignant neoplasm progression 81.15 21.85 5 64052 174562 110350680
Anxiety 79.79 21.85 403 63654 344675 110180567
Maternal exposure timing unspecified 79.10 21.85 78 63979 20935 110504307
Pleural effusion 77.19 21.85 7 64050 177702 110347540
Swollen joint count 76.91 21.85 53 64004 8621 110516621
COVID-19 75.40 21.85 24 64033 245036 110280206
Maternal exposure during pregnancy 73.86 21.85 318 63739 254565 110270677
Delirium 72.82 21.85 207 63850 134818 110390424
Abdominal discomfort 71.65 21.85 431 63626 393427 110131815
Pulmonary embolism 71.55 21.85 18 64039 214456 110310786
Hepatic cirrhosis 71.28 21.85 135 63922 67491 110457751
Multiple allergies 70.92 21.85 58 63999 12205 110513037
Somnolence 69.74 21.85 43 64014 297406 110227836
Therapeutic product effect decreased 69.40 21.85 303 63754 244013 110281229
Disease progression 68.12 21.85 28 64029 244006 110281236
Laboratory test abnormal 67.64 21.85 104 63953 43975 110481267
Foot deformity 66.96 21.85 109 63948 48371 110476871
Rheumatic disorder 65.89 21.85 35 64022 3556 110521686
Contraindicated product administered 65.33 21.85 301 63756 247966 110277276
Adverse event 64.81 21.85 173 63884 108636 110416606
Cardiac failure 64.04 21.85 15 64042 187611 110337631
Injection site pain 63.21 21.85 13 64044 177909 110347333
Hypersensitivity 61.12 21.85 422 63635 403576 110121666
Drug interaction 60.71 21.85 124 63933 500059 110025183
Neuropathy peripheral 59.88 21.85 15 64042 179262 110345980
Septic shock 59.19 21.85 10 64047 157518 110367724
Oxygen saturation decreased 58.91 21.85 10 64047 156972 110368270
Urticaria 58.64 21.85 350 63707 318507 110206735
Infection 57.56 21.85 383 63674 361817 110163425
Completed suicide 56.86 21.85 35 64022 242346 110282896
Hypercholesterolaemia 56.72 21.85 147 63910 90690 110434552
Joint dislocation 55.77 21.85 83 63974 34107 110491135
Ear infection 55.04 21.85 116 63941 62616 110462626
Chills 54.60 21.85 21 64036 190559 110334683
Multiple organ dysfunction syndrome 54.06 21.85 11 64046 151699 110373543
Decreased appetite 53.05 21.85 463 63594 475383 110049859
Drug abuse 51.75 21.85 19 64038 177392 110347850
Dysphagia 51.01 21.85 13 64044 153587 110371655
Electrocardiogram QT prolonged 51.00 21.85 3 64054 108957 110416285
Tremor 50.58 21.85 27 64030 202205 110323037
Cerebrovascular accident 50.26 21.85 21 64036 181263 110343979
General physical health deterioration 50.13 21.85 419 63638 424876 110100366
Sleep disorder due to a general medical condition 50.01 21.85 100 63957 52012 110473230
Cardiac failure congestive 49.73 21.85 13 64044 150987 110374255
Hypoxia 49.15 21.85 8 64049 129507 110395735
Ear pain 48.54 21.85 100 63957 53126 110472116
Chest discomfort 48.42 21.85 20 64037 173828 110351414
Hyperhidrosis 48.34 21.85 24 64033 187274 110337968
Bradycardia 48.24 21.85 15 64042 155502 110369740
Interstitial lung disease 47.82 21.85 11 64046 139323 110385919
Nasopharyngitis 47.25 21.85 390 63667 393971 110131271
Platelet count decreased 46.57 21.85 39 64018 230404 110294838
Abdominal distension 45.85 21.85 22 64035 175081 110350161
Haemoglobin decreased 44.50 21.85 47 64010 248680 110276562
Pancreatitis 44.33 21.85 137 63920 93396 110431846
Overdose 44.32 21.85 42 64015 233752 110291490
Adverse drug reaction 44.03 21.85 148 63909 105411 110419831
Infusion related reaction 43.57 21.85 373 63684 380789 110144453
Influenza 43.14 21.85 22 64035 169079 110356163
Chronic obstructive pulmonary disease 43.12 21.85 6 64051 109152 110416090
Frequent bowel movements 43.00 21.85 114 63943 71276 110453966
Blood pressure increased 42.76 21.85 52 64005 258321 110266921
Cardiac arrest 42.66 21.85 31 64026 196722 110328520
Renal failure 42.60 21.85 41 64016 226533 110298709
Depressed level of consciousness 42.46 21.85 7 64050 112271 110412971
Chest pain 42.33 21.85 367 63690 376008 110149234
Confusional state 42.25 21.85 436 63621 468244 110056998
Blood immunoglobulin M increased 41.93 21.85 20 64037 1617 110523625
Myalgia 40.94 21.85 41 64016 222340 110302902
Thrombosis 40.59 21.85 7 64050 108655 110416587
Back pain 40.05 21.85 98 63959 370898 110154344
Productive cough 39.27 21.85 9 64048 114296 110410946
White blood cell count decreased 39.21 21.85 45 64012 229345 110295897
Peripheral swelling 38.88 21.85 381 63676 403653 110121589
Feeling hot 38.23 21.85 128 63929 90978 110434264
Dyspnoea exertional 38.23 21.85 7 64050 104053 110421189
Cardio-respiratory arrest 38.09 21.85 10 64047 115826 110409416
Dry skin 37.95 21.85 8 64049 107645 110417597
Neurosis 37.87 21.85 14 64043 596 110524646
Hepatic function abnormal 37.50 21.85 4 64053 89291 110435951
Inflammation 37.36 21.85 215 63842 193023 110332219
Colitis 37.34 21.85 7 64050 102316 110422926
Intentional overdose 37.29 21.85 15 64042 132486 110392756
Feeling abnormal 37.23 21.85 30 64027 180681 110344561
Product use issue 37.18 21.85 308 63749 311387 110213855
Hyponatraemia 36.87 21.85 43 64014 217610 110307632
Hypokalaemia 36.70 21.85 31 64026 182417 110342825
Skin exfoliation 36.62 21.85 4 64053 87647 110437595
Colitis ulcerative 36.37 21.85 113 63944 77250 110447992
Mucosal inflammation 36.34 21.85 6 64051 96135 110429107
Epistaxis 36.30 21.85 15 64042 130357 110394885
Blood immunoglobulin A decreased 35.94 21.85 20 64037 2228 110523014
Migraine 35.85 21.85 195 63862 171457 110353785
Diabetes mellitus 35.84 21.85 7 64050 99374 110425868
Eye injury 35.33 21.85 32 64025 7723 110517519
Nasal congestion 35.28 21.85 7 64050 98275 110426967
Laryngeal disorder 35.23 21.85 16 64041 1157 110524085
Hallucination 34.82 21.85 8 64049 101424 110423818
Deep vein thrombosis 34.50 21.85 19 64038 139868 110385374
Incorrect dose administered 33.97 21.85 9 64048 103632 110421610
Pneumonitis 33.26 21.85 3 64054 76528 110448714
Thrombocytopenia 33.25 21.85 98 63959 348787 110176455
Fixed eruption 33.21 21.85 24 64033 4208 110521034
Erythema 33.04 21.85 75 63982 291372 110233870
Weight increased 33.01 21.85 380 63677 419264 110105978
Hypoglycaemia 32.91 21.85 13 64044 116091 110409151
Inappropriate schedule of product administration 32.63 21.85 42 64015 203595 110321647
Metabolic acidosis 32.06 21.85 9 64048 99735 110425507
Hypertension 31.25 21.85 441 63616 509643 110015599
Lethargy 30.91 21.85 8 64049 93568 110431674
Weight fluctuation 30.86 21.85 50 64007 22095 110503147
Pancytopenia 30.81 21.85 46 64011 209567 110315675
Encephalopathy 30.77 21.85 5 64052 81050 110444192
Haemoptysis 30.47 21.85 3 64054 71351 110453891
Hallucinations, mixed 30.38 21.85 31 64026 8662 110516580
Dyspepsia 30.33 21.85 202 63855 190763 110334479
Intestinal diaphragm disease 30.05 21.85 11 64046 455 110524787
Agitation 29.91 21.85 14 64043 113037 110412205
Haematuria 29.61 21.85 6 64051 82999 110442243
Incorrect route of product administration 29.58 21.85 93 63964 63968 110461274
Nausea 29.27 21.85 522 63535 1235168 109290074
Disability 29.00 21.85 58 63999 30165 110495077
Persistent depressive disorder 28.82 21.85 15 64042 1462 110523780
Hypothyroidism 28.81 21.85 4 64053 72895 110452347
Injection site reaction 28.70 21.85 8 64049 89062 110436180
Hyperglycaemia 28.64 21.85 7 64050 85083 110440159
Palpitations 28.56 21.85 30 64027 159182 110366060
Blood immunoglobulin G increased 28.53 21.85 21 64036 3787 110521455
Balance disorder 28.50 21.85 16 64041 116544 110408698
Acute respiratory failure 27.78 21.85 5 64052 75255 110449987
Aspartate aminotransferase increased 27.73 21.85 31 64026 159905 110365337
International normalised ratio increased 27.57 21.85 8 64049 86764 110438478
Heart rate increased 27.06 21.85 26 64031 143808 110381434
Suicide attempt 27.05 21.85 13 64044 103381 110421861
Dyspnoea 27.02 21.85 465 63592 1106407 109418835
Osteoporosis 26.97 21.85 111 63946 87041 110438201
Ascites 26.95 21.85 10 64047 92798 110432444
Neoplasm progression 26.85 21.85 3 64054 64592 110460650
Hyperkalaemia 26.19 21.85 24 64033 135772 110389470
Rash 26.15 21.85 641 63416 820323 109704919
Mental status changes 26.14 21.85 6 64051 76116 110449126
Depression 25.68 21.85 289 63768 317046 110208196
Condition aggravated 25.61 21.85 581 63476 734255 109790987
Myocardial infarction 25.56 21.85 45 64012 192038 110333204
Chest expansion decreased 25.54 21.85 8 64049 204 110525038
Illness 25.34 21.85 8 64049 82163 110443079
White blood cell count increased 25.14 21.85 117 63940 96725 110428517
Blood pressure decreased 25.12 21.85 18 64039 115073 110410169
Dysgeusia 25.08 21.85 5 64052 69980 110455262
Stress 24.99 21.85 15 64042 105333 110419909
Arrhythmia 24.88 21.85 5 64052 69570 110455672
Oropharyngeal pain 24.82 21.85 25 64032 135251 110389991
Rhabdomyolysis 24.78 21.85 20 64037 120381 110404861
Insomnia 24.63 21.85 318 63739 360272 110164970
Cellulitis 24.63 21.85 22 64035 125994 110399248
Hypomagnesaemia 24.61 21.85 3 64054 60367 110464875
Hepatic failure 24.45 21.85 5 64052 68734 110456508
Tachycardia 24.34 21.85 60 63997 226585 110298657
Blood bilirubin increased 24.15 21.85 7 64050 75965 110449277
Dysphonia 24.13 21.85 7 64050 75922 110449320
Unresponsive to stimuli 24.07 21.85 4 64053 63786 110461456
Muscular weakness 23.72 21.85 234 63823 248234 110277008
Secondary hypogonadism 23.51 21.85 11 64046 852 110524390
Orthostatic hypotension 23.19 21.85 5 64052 66244 110458998
Pneumonia aspiration 23.18 21.85 9 64048 81224 110444018
Red blood cell count decreased 23.03 21.85 5 64052 65918 110459324
Dysarthria 22.90 21.85 10 64047 84111 110441131
Haemorrhage 22.87 21.85 17 64040 106675 110418567
Acute myocardial infarction 22.74 21.85 10 64047 83767 110441475
Joint stiffness 22.70 21.85 88 63969 67155 110458087
Cardiac disorder 22.52 21.85 8 64049 76272 110448970
Disease recurrence 22.52 21.85 4 64053 60780 110464462
Rhinorrhoea 22.48 21.85 16 64041 102650 110422592
Lactic acidosis 22.32 21.85 13 64044 92798 110432444
Syncope 22.24 21.85 53 64004 202483 110322759
Palmoplantar pustulosis 22.11 21.85 11 64046 975 110524267

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M01AC01 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Oxicams
ATC M02AA07 MUSCULO-SKELETAL SYSTEM
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Antiinflammatory preparations, non-steroids for topical use
ATC S01BC06 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Antiinflammatory agents, non-steroids
FDA CS M0001335 Anti-Inflammatory Agents, Non-Steroidal
FDA MoA N0000000160 Cyclooxygenase Inhibitors
MeSH PA D000700 Analgesics
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018689 Sensory System Agents
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D016861 Cyclooxygenase Inhibitors
FDA EPC N0000175722 Nonsteroidal Anti-inflammatory Drug
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35544 EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:50630 cyclooxygenase 1 inhibitor
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:73336 vulnerary

Related Drugs by ATC class:

M01AC Oxicams 4 drugs
droxicamlornoxicammeloxicamtenoxicam
M02AA Antiinflammatory preparations, non-steroids for topical use 28 drugs
aceclofenacbendazacbenzydaminebufexamacclofezonedexketoprofendiclofenacesflurbiprofenetofenamatefelbinacfentiazacfeprazone show all 28 →
S01BC Antiinflammatory agents, non-steroids 10 drugs
bendazacbromfenacdiclofenacflurbiprofenindomethacinketorolacnepafenacoxyphenbutazonepranoprofensalicylic acid

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Rheumatoid arthritis indication 69896004 DOID:7148
Osteoarthritis indication 396275006
Ankylosing spondylitis off-label use 9631008 DOID:7147
Juvenile rheumatoid arthritis off-label use 410795001
Alcoholism contraindication 7200002
Asthenia contraindication 13791008
Myocardial infarction contraindication 22298006 DOID:5844
Hypertensive disorder contraindication 38341003 DOID:10763
Gastrointestinal ulcer contraindication 40845000
Body fluid retention contraindication 43498006
Chronic heart failure contraindication 48447003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Gastrointestinal perforation contraindication 51875005
Acute nephropathy contraindication 58574008
Blood coagulation disorder contraindication 64779008 DOID:1247
Gastrointestinal hemorrhage contraindication 74474003
Kidney disease contraindication 90708001 DOID:557
Liver function tests abnormal contraindication 166603001
Acute hepatic failure contraindication 197270009
Cerebrovascular accident contraindication 230690007
Coronary artery bypass graft contraindication 232717009
Disease of liver contraindication 235856003 DOID:409
Drug-induced hepatitis contraindication 235876009
Edema contraindication 267038008
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Cardiovascular event risk contraindication 395112001
Visual impairment contraindication 397540003
Thrombosis contraindication 439127006
Smokes tobacco daily contraindication 449868002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.31 acidic
pKa2 8.26 acidic
pKa3 5.18 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 4.70 WOMBAT-PK CHEMBL
Prostaglandin G/H synthase 1 Enzyme INHIBITOR IC50 5.18 WOMBAT-PK CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 4.68 CHEMBL
Cyclooxygenase Enzyme IC50 4.19 CHEMBL
Cyclooxygenase Enzyme IC50 7 CHEMBL

External reference:

IDSource
D00127 KEGG_DRUG
85056-47-9 SECONDARY_CAS_RN
4018626 VANDF
C0031990 UMLSCUI
CHEBI:8249 CHEBI
CHEMBL527 ChEMBL_ID
CHEMBL2106953 ChEMBL_ID
CHEMBL2108444 ChEMBL_ID
DB00554 DRUGBANK_ID
D010894 MESH_DESCRIPTOR_UI
54676228 PUBCHEM_CID
7273 IUPHAR_LIGAND_ID
C061072 MESH_SUPPLEMENTAL_RECORD_UI
3713 INN_ID
13T4O6VMAM UNII
197288 RXNORM
1529 MMSL
1753 MMSL
5308 MMSL
d00343 MMSL
002389 NDDF
006310 NDDF
27754002 SNOMEDCT_US
387153005 SNOMEDCT_US
421574004 SNOMEDCT_US
13T4O6VMAM INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Piroxicam HUMAN PRESCRIPTION DRUG LABEL 1 0093-0756 CAPSULE 10 mg ORAL ANDA 28 sections
Piroxicam HUMAN PRESCRIPTION DRUG LABEL 1 0093-0757 CAPSULE 20 mg ORAL ANDA 28 sections
PIROXICAM HUMAN PRESCRIPTION DRUG LABEL 1 16590-187 CAPSULE 10 mg ORAL ANDA 29 sections
PIROXICAM HUMAN PRESCRIPTION DRUG LABEL 1 16590-188 CAPSULE 20 mg ORAL ANDA 29 sections
Piroxicam HUMAN PRESCRIPTION DRUG LABEL 1 21695-285 CAPSULE 20 mg ORAL ANDA 29 sections
Piroxicam HUMAN PRESCRIPTION DRUG LABEL 1 21695-520 CAPSULE 10 mg ORAL ANDA 29 sections
Piroxicam HUMAN PRESCRIPTION DRUG LABEL 1 29033-012 CAPSULE 10 mg ORAL ANDA 29 sections
Piroxicam HUMAN PRESCRIPTION DRUG LABEL 1 29033-013 CAPSULE 20 mg ORAL ANDA 29 sections
Piroxicam HUMAN PRESCRIPTION DRUG LABEL 1 29300-255 CAPSULE 10 mg ORAL ANDA 20 sections
Piroxicam HUMAN PRESCRIPTION DRUG LABEL 1 29300-256 CAPSULE 20 mg ORAL ANDA 20 sections
Piroxicam HUMAN PRESCRIPTION DRUG LABEL 1 42254-062 CAPSULE 20 mg ORAL ANDA 29 sections
Piroxicam HUMAN PRESCRIPTION DRUG LABEL 1 42254-143 CAPSULE 10 mg ORAL ANDA 29 sections
Piroxicam HUMAN PRESCRIPTION DRUG LABEL 1 42291-953 CAPSULE 10 mg ORAL ANDA 24 sections
Piroxicam HUMAN PRESCRIPTION DRUG LABEL 1 42291-954 CAPSULE 20 mg ORAL ANDA 24 sections
Piroxicam HUMAN PRESCRIPTION DRUG LABEL 1 42543-114 CAPSULE 10 mg ORAL ANDA 29 sections
Piroxicam HUMAN PRESCRIPTION DRUG LABEL 1 42543-115 CAPSULE 20 mg ORAL ANDA 29 sections
PIROXICAM HUMAN PRESCRIPTION DRUG LABEL 1 42549-542 CAPSULE 20 mg ORAL ANDA 29 sections
PIROXICAM HUMAN PRESCRIPTION DRUG LABEL 1 42571-176 CAPSULE 10 mg ORAL ANDA 28 sections
PIROXICAM HUMAN PRESCRIPTION DRUG LABEL 1 42571-177 CAPSULE 20 mg ORAL ANDA 28 sections
PIROXICAM HUMAN PRESCRIPTION DRUG LABEL 1 50090-4779 CAPSULE 20 mg ORAL ANDA 28 sections
Piroxicam HUMAN PRESCRIPTION DRUG LABEL 1 52959-232 CAPSULE 20 mg ORAL ANDA 29 sections
Piroxicam HUMAN PRESCRIPTION DRUG LABEL 1 52959-398 CAPSULE 10 mg ORAL ANDA 29 sections
Piroxicam HUMAN PRESCRIPTION DRUG LABEL 1 54868-2198 CAPSULE 10 mg ORAL ANDA 29 sections
Piroxicam HUMAN PRESCRIPTION DRUG LABEL 1 54868-2199 CAPSULE 20 mg ORAL ANDA 29 sections
piroxicam HUMAN PRESCRIPTION DRUG LABEL 1 61919-188 CAPSULE 20 mg ORAL ANDA 12 sections
PIROXICAM HUMAN PRESCRIPTION DRUG LABEL 1 61919-193 CAPSULE 20 mg ORAL ANDA 15 sections
Piroxicam HUMAN PRESCRIPTION DRUG LABEL 1 63629-9148 CAPSULE 10 mg ORAL ANDA 29 sections
Piroxicam HUMAN PRESCRIPTION DRUG LABEL 1 63629-9149 CAPSULE 20 mg ORAL ANDA 29 sections
Piroxicam HUMAN PRESCRIPTION DRUG LABEL 1 63629-9150 CAPSULE 20 mg ORAL ANDA 29 sections
Piroxicam HUMAN PRESCRIPTION DRUG LABEL 1 64380-842 CAPSULE 10 mg ORAL ANDA 25 sections