piracetam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
amide type nootrope agents, piracetam derivatives	2197	7491-74-9

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

piracetam
2-Pyrrolidinoneacetamide
neuracetam
pirazetam
nootropil

A compound suggested to be both a nootropic and a neuroprotective agent.

Molecular weight: 142.16
Formula: C6H10N2O2
CLOGP: -1.18
LIPINSKI: 0
HAC: 4
HDO: 1
TPSA: 63.40
ALOGS: 0.53
ROTB: 2

Drug dosage:

Dose	Unit	Route
2.40	g	O
6	g	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	3	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	70 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	803.93 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

Date	Agency	Company	Orphan
Jan. 1, 1972	YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Central nervous system injury	63.24	33.53	9	1232	142	63487639
Splenic injury	52.26	33.53	8	1233	212	63487569
Neuroleptic malignant syndrome	51.82	33.53	16	1225	12040	63475741
Hyperchloraemia	48.67	33.53	9	1232	754	63487027
Hypochromasia	48.50	33.53	8	1233	344	63487437
Petechiae	45.53	33.53	15	1226	13882	63473899
Anisocytosis	42.81	33.53	8	1233	710	63487071
Intestinal pseudo-obstruction	40.90	33.53	8	1233	904	63486877
Drug interaction	39.75	33.53	34	1207	229097	63258684
Bradycardia	34.31	33.53	20	1221	73207	63414574
Hyperaemia	33.67	33.53	8	1233	2251	63485530

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Parkinsonism	62.05	31.92	18	907	8120	34947886

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Central nervous system injury	60.36	33.04	9	1976	154	79742249
Splenic injury	48.62	33.04	8	1977	264	79742139
Hyperchloraemia	43.03	33.04	9	1976	1112	79741291
Hypochromasia	41.11	33.04	8	1977	688	79741715
Neuroleptic malignant syndrome	38.33	33.04	17	1968	27542	79714861
Anisocytosis	37.92	33.04	8	1977	1031	79741372
Petechiae	36.23	33.04	15	1970	20550	79721853

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N06BX03	NERVOUS SYSTEM PSYCHOANALEPTICS PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS Other psychostimulants and nootropics
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D018696	Neuroprotective Agents
MeSH PA	D018697	Nootropic Agents
MeSH PA	D020011	Protective Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	13.28	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
N0000007934	NUI
D01914	KEGG_DRUG
4036333	VANDF
C0031977	UMLSCUI
CHEBI:32010	CHEBI
PZI	PDB_CHEM_ID
CHEMBL36715	ChEMBL_ID
DB09210	DRUGBANK_ID
D010889	MESH_DESCRIPTOR_UI
4843	PUBCHEM_CID
2687	INN_ID
4288	IUPHAR_LIGAND_ID
ZH516LNZ10	UNII
8351	RXNORM
NOCODE	MMSL
004363	NDDF
322998004	SNOMEDCT_US
395833008	SNOMEDCT_US

Pharmaceutical products:

None