piracetam ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
amide type nootrope agents, piracetam derivatives 2197 7491-74-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • piracetam
  • 2-Pyrrolidinoneacetamide
  • neuracetam
  • pirazetam
  • nootropil
A compound suggested to be both a nootropic and a neuroprotective agent.
  • Molecular weight: 142.16
  • Formula: C6H10N2O2
  • CLOGP: -1.18
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 63.40
  • ALOGS: 0.53
  • ROTB: 2

Drug dosage:

DoseUnitRoute
2.40 g O
6 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 70 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 803.93 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1972 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Central nervous system injury 63.38 35.34 9 1013 135 50603967
Splenic injury 52.89 35.34 8 1014 189 50603913
Neuroleptic malignant syndrome 52.59 35.34 16 1006 11114 50592988
Hyperchloraemia 49.15 35.34 9 1013 692 50603410
Hypochromasia 48.76 35.34 8 1014 322 50603780
Anisocytosis 44.24 35.34 8 1014 573 50603529
Drug interaction 42.97 35.34 34 988 199587 50404515
Petechiae 42.55 35.34 14 1008 12498 50591604
Intestinal pseudo-obstruction 42.16 35.34 8 1014 746 50603356
Bradycardia 36.12 35.34 20 1002 64406 50539696

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Central nervous system injury 60.91 33.61 9 1570 147 64497006
Splenic injury 49.53 33.61 8 1571 239 64496914
Hyperchloraemia 44.40 33.61 9 1570 970 64496183
Hypochromasia 41.68 33.61 8 1571 652 64496501
Neuroleptic malignant syndrome 40.21 33.61 17 1562 24979 64472174
Anisocytosis 39.53 33.61 8 1571 855 64496298
Petechiae 34.46 33.61 14 1565 18612 64478541

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N06BX03 NERVOUS SYSTEM
PSYCHOANALEPTICS
PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
Other psychostimulants and nootropics
MeSH PA D002491 Central Nervous System Agents
MeSH PA D018696 Neuroprotective Agents
MeSH PA D018697 Nootropic Agents
MeSH PA D020011 Protective Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.28 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
N0000007934 NUI
D01914 KEGG_DRUG
4036333 VANDF
C0031977 UMLSCUI
CHEBI:32010 CHEBI
PZI PDB_CHEM_ID
CHEMBL36715 ChEMBL_ID
DB09210 DRUGBANK_ID
D010889 MESH_DESCRIPTOR_UI
4843 PUBCHEM_CID
2687 INN_ID
4288 IUPHAR_LIGAND_ID
ZH516LNZ10 UNII
8351 RXNORM
NOCODE MMSL
004363 NDDF
322998004 SNOMEDCT_US
395833008 SNOMEDCT_US

Pharmaceutical products:

None