piracetam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
amide type nootrope agents, piracetam derivatives	2197	7491-74-9

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

piracetam
2-Pyrrolidinoneacetamide
neuracetam
pirazetam
nootropil

A compound suggested to be both a nootropic and a neuroprotective agent.

Molecular weight: 142.16
Formula: C6H10N2O2
CLOGP: -1.18
LIPINSKI: 0
HAC: 4
HDO: 1
TPSA: 63.40
ALOGS: 0.53
ROTB: 2

Drug dosage:

Dose	Unit	Route
2.40	g	O
6	g	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	3	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	70 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	803.93 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

Date	Agency	Company	Orphan
Jan. 1, 1972	YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Central nervous system injury	63.38	35.34	9	1013	135	50603967
Splenic injury	52.89	35.34	8	1014	189	50603913
Neuroleptic malignant syndrome	52.59	35.34	16	1006	11114	50592988
Hyperchloraemia	49.15	35.34	9	1013	692	50603410
Hypochromasia	48.76	35.34	8	1014	322	50603780
Anisocytosis	44.24	35.34	8	1014	573	50603529
Drug interaction	42.97	35.34	34	988	199587	50404515
Petechiae	42.55	35.34	14	1008	12498	50591604
Intestinal pseudo-obstruction	42.16	35.34	8	1014	746	50603356
Bradycardia	36.12	35.34	20	1002	64406	50539696

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Central nervous system injury	60.91	33.61	9	1570	147	64497006
Splenic injury	49.53	33.61	8	1571	239	64496914
Hyperchloraemia	44.40	33.61	9	1570	970	64496183
Hypochromasia	41.68	33.61	8	1571	652	64496501
Neuroleptic malignant syndrome	40.21	33.61	17	1562	24979	64472174
Anisocytosis	39.53	33.61	8	1571	855	64496298
Petechiae	34.46	33.61	14	1565	18612	64478541

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N06BX03	NERVOUS SYSTEM PSYCHOANALEPTICS PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS Other psychostimulants and nootropics
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D018696	Neuroprotective Agents
MeSH PA	D018697	Nootropic Agents
MeSH PA	D020011	Protective Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	13.28	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
N0000007934	NUI
D01914	KEGG_DRUG
4036333	VANDF
C0031977	UMLSCUI
CHEBI:32010	CHEBI
PZI	PDB_CHEM_ID
CHEMBL36715	ChEMBL_ID
DB09210	DRUGBANK_ID
D010889	MESH_DESCRIPTOR_UI
4843	PUBCHEM_CID
2687	INN_ID
4288	IUPHAR_LIGAND_ID
ZH516LNZ10	UNII
8351	RXNORM
NOCODE	MMSL
004363	NDDF
322998004	SNOMEDCT_US
395833008	SNOMEDCT_US

Pharmaceutical products:

None