pinaverium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
quaternary ammonium compounds 2174 59995-65-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pinaverium
  • pinaverium bromide
  • Molecular weight: 511.52
  • Formula: C26H41BrNO4
  • CLOGP: 5.39
  • LIPINSKI: 2
  • HAC: 5
  • HDO: 0
  • TPSA: 36.92
  • ALOGS: -8.20
  • ROTB: 10

Drug dosage:

DoseUnitRoute
0.15 g O

ADMET properties:

PropertyValueReference
S (Water solubility) 16 mg/mL Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Bocci G, Oprea TI, Benet LZ
BA (Bioavailability) 0 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,JAK3,MAP3K7,MAPK10,MAPK7,MAPKAPK2,MET,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CG,PIM2,PRKDC,STK33,TEK,TTK,ZAP70 40
kinase-selectivity-class AXL,EIF2AK3,GRK2 3
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Heart sounds 169.27 38.25 28 1921 1116 90625382
Prolonged expiration 166.63 38.25 28 1921 1229 90625269
Depressive symptom 126.50 38.25 28 1921 5257 90621241
Appetite disorder 121.29 38.25 30 1919 9103 90617395
Respiration abnormal 120.21 38.25 29 1920 7934 90618564
Rales 96.02 38.25 28 1921 15799 90610699
Flank pain 94.89 38.25 29 1920 19193 90607305
Angina pectoris 78.25 38.25 30 1919 39130 90587368
Sleep disorder due to a general medical condition 70.94 38.25 29 1920 44709 90581789
Stress 68.88 38.25 34 1915 81361 90545137
Depressed mood 67.70 38.25 29 1920 50193 90576305
Productive cough 61.67 38.25 31 1918 77032 90549466
Dyspnoea exertional 60.56 38.25 30 1919 72258 90554240
Rhinorrhoea 60.51 38.25 32 1917 88284 90538214
Nasal congestion 59.35 38.25 31 1918 83383 90543115
Chest discomfort 47.20 38.25 32 1917 138333 90488165
Influenza 47.01 38.25 32 1917 139232 90487266
Upper respiratory tract infection 44.54 38.25 30 1919 128288 90498210
Asthma 43.01 38.25 38 1911 242122 90384376

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Heart sounds 169.93 33.50 28 2294 1115 110585862
Prolonged expiration 161.37 33.50 28 2294 1524 110585453
Appetite disorder 119.96 33.50 30 2292 9739 110577238
Respiration abnormal 114.86 33.50 29 2293 9780 110577197
Depressive symptom 114.18 33.50 28 2294 8386 110578591
Flank pain 90.26 33.50 29 2293 23101 110563876
Rales 84.33 33.50 28 2294 24711 110562266
Sleep disorder due to a general medical condition 67.30 33.50 29 2293 52083 110534894
Angina pectoris 65.47 33.50 30 2292 62265 110524712
Depressed mood 63.01 33.50 29 2293 60780 110526197
Rhinorrhoea 62.16 33.50 34 2288 102632 110484345
Stress 61.34 33.50 34 2288 105314 110481663
Nasal congestion 55.24 33.50 31 2291 98251 110488726
Dyspnoea exertional 50.94 33.50 30 2292 104030 110482947
Productive cough 50.89 33.50 31 2291 114274 110472703
Upper respiratory tract infection 46.94 33.50 31 2291 131297 110455680
Chest discomfort 45.72 33.50 34 2288 173814 110413163
Influenza 42.08 33.50 32 2290 169069 110417908
Asthma 40.69 33.50 37 2285 250254 110336723
Lower respiratory tract infection 39.63 33.50 36 2286 243070 110343907
Injury 38.60 33.50 31 2291 177234 110409743
Weight decreased 36.68 33.50 47 2275 468010 110118967
Nasopharyngitis 34.73 33.50 42 2280 394319 110192658
Insomnia 34.38 33.50 40 2282 360550 110226427
Malaise 34.31 33.50 55 2267 671764 109915213

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A03AX04 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
Other drugs for functional gastrointestinal disorders
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D002317 Cardiovascular Agents
MeSH PA D010276 Parasympatholytics
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D049990 Membrane Transport Modulators

Related Drugs by ATC class:

A03AX Other drugs for functional gastrointestinal disorders 13 drugs
alverinecaroverinechlorbenzoxaminediisoprominefenoverinefenpipraneidanpramineisometheptenephloroglucinolproxazoletrepibutonetrimethyldiphenylpropylamine show all 13 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07094 KEGG_DRUG
C0071081 UMLSCUI
CHEBI:135811 CHEBI
CHEMBL1909324 ChEMBL_ID
CHEMBL1909298 ChEMBL_ID
DB09090 DRUGBANK_ID
C013199 MESH_SUPPLEMENTAL_RECORD_UI
53251-94-8 SECONDARY_CAS_RN
U2368VVE7O UNII
40704 PUBCHEM_CID
33724 RXNORM
003872 NDDF
003873 NDDF
698023008 SNOMEDCT_US
3696 INN_ID
U2368VVE7O INXIGHT DRUGS

Pharmaceutical products:

None