pinaverium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| quaternary ammonium compounds | 2174 | 59995-65-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.15 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 16 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Bocci G, Oprea TI, Benet LZ |
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Heart sounds | 148.94 | 40.27 | 25 | 1505 | 971 | 63486521 |
| Prolonged expiration | 146.55 | 40.27 | 25 | 1505 | 1071 | 63486421 |
| Depressive symptom | 113.63 | 40.27 | 25 | 1505 | 4077 | 63483415 |
| Respiration abnormal | 107.62 | 40.27 | 26 | 1504 | 6391 | 63481101 |
| Appetite disorder | 104.21 | 40.27 | 26 | 1504 | 7295 | 63480197 |
| Sleep disorder due to a general medical condition | 91.08 | 40.27 | 26 | 1504 | 12162 | 63475330 |
| Rales | 85.58 | 40.27 | 25 | 1505 | 12672 | 63474820 |
| Flank pain | 83.44 | 40.27 | 26 | 1504 | 16384 | 63471108 |
| Angina pectoris | 68.01 | 40.27 | 26 | 1504 | 30052 | 63457440 |
| Depressed mood | 60.72 | 40.27 | 26 | 1504 | 40165 | 63447327 |
| Stress | 59.47 | 40.27 | 30 | 1500 | 67137 | 63420355 |
| Rhinorrhoea | 57.21 | 40.27 | 29 | 1501 | 65548 | 63421944 |
| Productive cough | 52.36 | 40.27 | 27 | 1503 | 63181 | 63424311 |
| Nasal congestion | 51.39 | 40.27 | 27 | 1503 | 65633 | 63421859 |
| Asthma | 51.10 | 40.27 | 34 | 1496 | 127527 | 63359965 |
| Injury | 48.62 | 40.27 | 27 | 1503 | 73220 | 63414272 |
| Dyspnoea exertional | 47.76 | 40.27 | 25 | 1505 | 60277 | 63427215 |
| Wheezing | 44.46 | 40.27 | 28 | 1502 | 95567 | 63391925 |
| Chest discomfort | 43.27 | 40.27 | 29 | 1501 | 109940 | 63377552 |
| Upper respiratory tract infection | 43.15 | 40.27 | 26 | 1504 | 82021 | 63405471 |
| Influenza | 41.16 | 40.27 | 28 | 1502 | 108694 | 63378798 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Heart sounds | 144.42 | 36.74 | 24 | 1765 | 942 | 79741657 |
| Prolonged expiration | 137.84 | 36.74 | 24 | 1765 | 1247 | 79741352 |
| Appetite disorder | 99.59 | 36.74 | 25 | 1764 | 7714 | 79734885 |
| Respiration abnormal | 99.43 | 36.74 | 25 | 1764 | 7763 | 79734836 |
| Depressive symptom | 99.07 | 36.74 | 24 | 1765 | 6399 | 79736200 |
| Sleep disorder due to a general medical condition | 84.43 | 36.74 | 25 | 1764 | 14252 | 79728347 |
| Flank pain | 76.32 | 36.74 | 25 | 1764 | 19819 | 79722780 |
| Rales | 72.11 | 36.74 | 24 | 1765 | 19977 | 79722622 |
| Rhinorrhoea | 57.93 | 36.74 | 30 | 1759 | 76044 | 79666555 |
| Depressed mood | 54.62 | 36.74 | 25 | 1764 | 48455 | 79694144 |
| Angina pectoris | 53.07 | 36.74 | 25 | 1764 | 51707 | 79690892 |
| Stress | 51.04 | 36.74 | 28 | 1761 | 79584 | 79663015 |
| Injury | 48.97 | 36.74 | 27 | 1762 | 77469 | 79665130 |
| Asthma | 46.69 | 36.74 | 32 | 1757 | 135063 | 79607536 |
| Nasal congestion | 46.53 | 36.74 | 26 | 1763 | 76526 | 79666073 |
| Productive cough | 43.07 | 36.74 | 26 | 1763 | 88305 | 79654294 |
| Upper respiratory tract infection | 42.31 | 36.74 | 26 | 1763 | 91142 | 79651457 |
| Chest discomfort | 39.16 | 36.74 | 29 | 1760 | 138015 | 79604584 |
| Dyspnoea exertional | 38.29 | 36.74 | 24 | 1765 | 87049 | 79655550 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A03AX04 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS Other drugs for functional gastrointestinal disorders |
| MeSH PA | D002121 | Calcium Channel Blockers |
| MeSH PA | D000077264 | Calcium-Regulating Hormones and Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D049990 | Membrane Transport Modulators |
| MeSH PA | D010276 | Parasympatholytics |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D07094 | KEGG_DRUG |
| C0071081 | UMLSCUI |
| CHEBI:135811 | CHEBI |
| CHEMBL1909324 | ChEMBL_ID |
| DB09090 | DRUGBANK_ID |
| C013199 | MESH_SUPPLEMENTAL_RECORD_UI |
| 53251-94-8 | SECONDARY_CAS_RN |
| U2368VVE7O | UNII |
| 40704 | PUBCHEM_CID |
| 33724 | RXNORM |
| 003872 | NDDF |
| 003873 | NDDF |
| 698023008 | SNOMEDCT_US |
| CHEMBL1909298 | ChEMBL_ID |
| 3696 | INN_ID |
Pharmaceutical products:
None