alverine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
spasmolytics with a papaverine-like action 142 150-59-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alverine hydrochloride
  • alverine
  • dipropylin
  • dipropyline
  • phenopropamine
  • phenpropamine
  • alverine citrate
  • alverine citrate salt
  • Molecular weight: 281.44
  • Formula: C20H27N
  • CLOGP: 5.50
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 0
  • TPSA: 3.24
  • ALOGS: -5.47
  • ROTB: 9

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT1,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MET,MTOR,NTRK2,PAK4,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK 48
kinase-selectivity-class AKT3,AXL,CAMK2D,EIF2AK3,EPHB4,GRK2,PDK4,PRKCD,SIK2,STK33,TEK 11
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A03AX08 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
Other drugs for functional gastrointestinal disorders
ATC A03AX58 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
Other drugs for functional gastrointestinal disorders
MeSH PA D010276 Parasympatholytics
MeSH PA D018373 Peripheral Nervous System Agents
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:48873 cholinergic antagonist
CHEBI has role CHEBI:53784 antispasmodic drug

Related Drugs by ATC class:

A03AX Other drugs for functional gastrointestinal disorders 13 drugs
caroverinechlorbenzoxaminediisoprominefenoverinefenpipraneidanpramineisometheptenephloroglucinolpinaveriumproxazoletrepibutonetrimethyldiphenylpropylamine show all 13 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.35 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D02877 KEGG_DRUG
5982-87-6 SECONDARY_CAS_RN
17627 RXNORM
C0051528 UMLSCUI
CHEBI:518413 CHEBI
CHEMBL253371 ChEMBL_ID
DB01616 DRUGBANK_ID
C010846 MESH_SUPPLEMENTAL_RECORD_UI
3678 PUBCHEM_CID
14185 IUPHAR_LIGAND_ID
95 INN_ID
5560-59-8 SECONDARY_CAS_RN
46TIR1560O UNII
CHEMBL1408594 ChEMBL_ID
001763 NDDF
001764 NDDF
349818006 SNOMEDCT_US
418483003 SNOMEDCT_US
91023007 SNOMEDCT_US
46TIR1560O INXIGHT DRUGS

Pharmaceutical products:

None