phloroglucinol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2153 108-73-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • phloroglucinol
  • phloroglucin
  • phloroglucine
  • 1,3,5-Benzenetriol
A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.
  • Molecular weight: 126.11
  • Formula: C6H6O3
  • CLOGP: 0.14
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 3
  • TPSA: 60.69
  • ALOGS: -0.55
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hepatocellular injury 91.96 38.17 35 1847 25912 50577330
Cell death 58.03 38.17 14 1868 2201 50601041
Cholestasis 54.73 38.17 24 1858 25377 50577865
Hyponatraemia 41.93 38.17 32 1850 96107 50507135
Febrile bone marrow aplasia 39.47 38.17 13 1869 6298 50596944
Hepatosplenic candidiasis 39.06 38.17 7 1875 255 50602987
Rash maculo-papular 38.20 38.17 19 1863 26622 50576620

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pancreatitis acute 70.71 33.24 29 1153 24356 29548989
Urethral valves 64.74 33.24 11 1171 272 29573073
Hyperleukocytosis 45.50 33.24 11 1171 1624 29571721
Puncture site haematoma 35.24 33.24 6 1176 150 29573195
Diarrhoea infectious 34.51 33.24 7 1175 461 29572884
Acute kidney injury 34.16 33.24 47 1135 265220 29308125

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hepatocellular injury 109.27 32.08 50 3053 45185 64450444
Pancreatitis acute 89.95 32.08 43 3060 42812 64452817
Acute kidney injury 62.22 32.08 91 3012 449149 64046480
Cholestasis 59.30 32.08 33 3070 44839 64450790
Cell death 54.75 32.08 16 3087 4038 64491591
Febrile bone marrow aplasia 49.20 32.08 19 3084 11236 64484393
Drug reaction with eosinophilia and systemic symptoms 48.47 32.08 31 3072 54186 64441443
Hyperleukocytosis 45.80 32.08 12 3091 2028 64493601
Hypokalaemia 37.18 32.08 37 3066 121866 64373763
Rash maculo-papular 35.02 32.08 24 3079 47002 64448627
Puncture site haematoma 33.57 32.08 6 3097 165 64495464
Hyponatraemia 32.84 32.08 38 3065 148301 64347328
Porphyria 32.48 32.08 6 3097 199 64495430
Hepatosplenic candidiasis 32.46 32.08 7 3096 514 64495115
Acute generalised exanthematous pustulosis 32.20 32.08 15 3088 14043 64481586

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A03AX12 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
Other drugs for functional gastrointestinal disorders
MeSH PA D007202 Indicators and Reagents
CHEBI has role CHEBI:84735 algal metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.35 acidic
pKa2 10.35 acidic
pKa3 12.36 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-secretase 1 Enzyme IC50 4.44 CHEMBL

External reference:

IDSource
N0000166595 NUI
D00152 KEGG_DRUG
C0031566 UMLSCUI
CHEBI:16204 CHEBI
13X PDB_CHEM_ID
CHEMBL473159 ChEMBL_ID
359 PUBCHEM_CID
DB12944 DRUGBANK_ID
D010696 MESH_DESCRIPTOR_UI
DHD7FFG6YS UNII
8196 RXNORM
005931 NDDF
19341000122103 SNOMEDCT_US

Pharmaceutical products:

None