pilsicainide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| Class I antiarrhythmics, procainamide and lidocaine derivatives | 2167 | 88069-67-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 5 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Bocci G, Oprea TI, Benet LZ |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Cerebral infarction | 57.24 | 37.44 | 19 | 436 | 27436 | 34929040 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Cerebral infarction | 66.38 | 33.76 | 24 | 981 | 45652 | 79697731 |
| Cardiac tamponade | 39.16 | 33.76 | 11 | 994 | 9265 | 79734118 |
| Cardiac failure | 35.91 | 33.76 | 23 | 982 | 154819 | 79588564 |
| Cerebral haemorrhage | 34.31 | 33.76 | 16 | 989 | 57657 | 79685726 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000889 | Anti-Arrhythmia Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D049990 | Membrane Transport Modulators |
| MeSH PA | D026941 | Sodium Channel Blockers |
| CHEBI has role | CHEBI:38070 | antiarrhythmic agent |
| CHEBI has role | CHEBI:38633 | sodium channel blockers |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Tachyarrhythmia | indication | 6285003 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.97 | acidic |
| pKa2 | 9.08 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sodium channel protein type 4 subunit alpha | Ion channel | BLOCKER | IC50 | 4.38 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 4.69 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D01554 | KEGG_DRUG |
| C0164155 | UMLSCUI |
| CHEBI:135127 | CHEBI |
| CHEMBL163238 | ChEMBL_ID |
| DB12712 | DRUGBANK_ID |
| C042288 | MESH_SUPPLEMENTAL_RECORD_UI |
| 4820 | PUBCHEM_CID |
| 6554 | INN_ID |
| 88069-49-2 | SECONDARY_CAS_RN |
| AV0X7V6CSE | UNII |
Pharmaceutical products:
None