Stem definition | Drug id | CAS RN |
---|---|---|
antiepileptics, hydantoin derivatives | 2152 | 57-41-0 |
Dose | Unit | Route |
---|---|---|
0.30 | g | O |
0.30 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.02 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 2 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 19.82 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 90 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.43 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 0.37 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.13 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 16.80 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Jan. 6, 1953 | FDA | PARKE DAVIS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Seizure | 1475.09 | 12.69 | 919 | 29811 | 128590 | 53189746 |
Status epilepticus | 672.79 | 12.69 | 272 | 30458 | 14912 | 53303424 |
Toxicity to various agents | 496.01 | 12.69 | 620 | 30110 | 218978 | 53099358 |
Drug reaction with eosinophilia and systemic symptoms | 476.04 | 12.69 | 273 | 30457 | 32527 | 53285809 |
Ataxia | 460.09 | 12.69 | 206 | 30524 | 14531 | 53303805 |
Anticonvulsant drug level increased | 440.00 | 12.69 | 112 | 30618 | 1308 | 53317028 |
Epilepsy | 429.73 | 12.69 | 235 | 30495 | 25532 | 53292804 |
Drug interaction | 372.09 | 12.69 | 539 | 30191 | 218790 | 53099546 |
Generalised tonic-clonic seizure | 363.64 | 12.69 | 219 | 30511 | 28539 | 53289797 |
Nystagmus | 344.52 | 12.69 | 130 | 30600 | 5906 | 53312430 |
Anticonvulsant drug level decreased | 317.28 | 12.69 | 84 | 30646 | 1156 | 53317180 |
Drug hypersensitivity | 283.11 | 12.69 | 529 | 30201 | 264713 | 53053623 |
Stevens-Johnson syndrome | 264.59 | 12.69 | 169 | 30561 | 24413 | 53293923 |
Purple glove syndrome | 226.79 | 12.69 | 46 | 30684 | 167 | 53318169 |
Anticonvulsant drug level above therapeutic | 212.63 | 12.69 | 51 | 30679 | 456 | 53317880 |
Multiple-drug resistance | 211.50 | 12.69 | 77 | 30653 | 3158 | 53315178 |
Anticonvulsant drug level below therapeutic | 196.47 | 12.69 | 49 | 30681 | 523 | 53317813 |
Cerebellar atrophy | 183.66 | 12.69 | 48 | 30682 | 626 | 53317710 |
Drug level decreased | 153.65 | 12.69 | 76 | 30654 | 6698 | 53311638 |
Toxic epidermal necrolysis | 153.17 | 12.69 | 119 | 30611 | 23431 | 53294905 |
Partial seizures | 123.92 | 12.69 | 61 | 30669 | 5319 | 53313017 |
Electroencephalogram abnormal | 102.19 | 12.69 | 48 | 30682 | 3773 | 53314563 |
Drug level increased | 98.94 | 12.69 | 87 | 30643 | 20334 | 53298002 |
Pain | 95.12 | 12.69 | 120 | 30610 | 588278 | 52730058 |
Arthralgia | 93.84 | 12.69 | 70 | 30660 | 439713 | 52878623 |
Product complaint | 90.88 | 12.69 | 67 | 30663 | 12190 | 53306146 |
Rheumatoid arthritis | 90.64 | 12.69 | 34 | 30696 | 314497 | 53003839 |
Diarrhoea | 87.82 | 12.69 | 141 | 30589 | 625405 | 52692931 |
Rash maculo-papular | 84.94 | 12.69 | 95 | 30635 | 29654 | 53288682 |
Diplopia | 84.07 | 12.69 | 80 | 30650 | 20685 | 53297651 |
Dyspnoea | 77.75 | 12.69 | 137 | 30593 | 586095 | 52732241 |
Fatigue | 77.42 | 12.69 | 194 | 30536 | 730312 | 52588024 |
Gingival hypertrophy | 77.09 | 12.69 | 30 | 30700 | 1481 | 53316855 |
Focal dyscognitive seizures | 76.02 | 12.69 | 36 | 30694 | 2881 | 53315455 |
Anticonvulsant drug level abnormal | 75.42 | 12.69 | 14 | 30716 | 27 | 53318309 |
Drug ineffective | 74.71 | 12.69 | 757 | 29973 | 816488 | 52501848 |
Drug ineffective for unapproved indication | 73.02 | 12.69 | 74 | 30656 | 20646 | 53297690 |
Drug resistance | 71.64 | 12.69 | 72 | 30658 | 19890 | 53298446 |
Alopecia | 71.60 | 12.69 | 23 | 30707 | 234560 | 53083776 |
Joint swelling | 69.88 | 12.69 | 24 | 30706 | 234614 | 53083722 |
Renal ischaemia | 69.44 | 12.69 | 22 | 30708 | 586 | 53317750 |
Dysarthria | 68.84 | 12.69 | 100 | 30630 | 40468 | 53277868 |
Encephalopathy | 67.27 | 12.69 | 94 | 30636 | 36714 | 53281622 |
Intra-abdominal pressure increased | 66.26 | 12.69 | 17 | 30713 | 205 | 53318131 |
Coma | 65.25 | 12.69 | 123 | 30607 | 61660 | 53256676 |
Abdominal discomfort | 65.15 | 12.69 | 23 | 30707 | 221039 | 53097297 |
Diabetes insipidus | 64.55 | 12.69 | 31 | 30699 | 2560 | 53315776 |
Arthropathy | 62.62 | 12.69 | 5 | 30725 | 141448 | 53176888 |
Cerebellar ataxia | 60.49 | 12.69 | 22 | 30708 | 899 | 53317437 |
Porphyria acute | 59.24 | 12.69 | 19 | 30711 | 527 | 53317809 |
Pneumatosis | 58.59 | 12.69 | 18 | 30712 | 432 | 53317904 |
Erythema multiforme | 58.12 | 12.69 | 48 | 30682 | 10301 | 53308035 |
PO2 increased | 57.39 | 12.69 | 21 | 30709 | 873 | 53317463 |
Drug level below therapeutic | 56.57 | 12.69 | 32 | 30698 | 3701 | 53314635 |
PCO2 increased | 54.08 | 12.69 | 22 | 30708 | 1221 | 53317115 |
Dyskinesia | 53.33 | 12.69 | 78 | 30652 | 31755 | 53286581 |
Sinusitis | 50.58 | 12.69 | 17 | 30713 | 168547 | 53149789 |
Bradycardia neonatal | 49.87 | 12.69 | 19 | 30711 | 885 | 53317451 |
Brain oedema | 48.82 | 12.69 | 49 | 30681 | 13509 | 53304827 |
Respiratory disorder neonatal | 48.21 | 12.69 | 19 | 30711 | 970 | 53317366 |
Necrosis ischaemic | 47.19 | 12.69 | 18 | 30712 | 841 | 53317495 |
Multiple organ dysfunction syndrome | 47.01 | 12.69 | 101 | 30629 | 55576 | 53262760 |
Nausea | 46.20 | 12.69 | 252 | 30478 | 755839 | 52562497 |
Neurodegenerative disorder | 46.18 | 12.69 | 14 | 30716 | 321 | 53318015 |
Neurotoxicity | 45.50 | 12.69 | 50 | 30680 | 15299 | 53303037 |
Choreoathetosis | 45.46 | 12.69 | 15 | 30715 | 456 | 53317880 |
Stupor | 45.22 | 12.69 | 28 | 30702 | 3823 | 53314513 |
Pemphigus | 45.15 | 12.69 | 4 | 30726 | 104027 | 53214309 |
Injection site pain | 45.05 | 12.69 | 6 | 30724 | 113385 | 53204951 |
Weight gain poor | 44.15 | 12.69 | 17 | 30713 | 815 | 53317521 |
Blood bicarbonate decreased | 43.83 | 12.69 | 25 | 30705 | 2937 | 53315399 |
Blood pH decreased | 43.83 | 12.69 | 24 | 30706 | 2606 | 53315730 |
Foetal anticonvulsant syndrome | 43.78 | 12.69 | 15 | 30715 | 513 | 53317823 |
Encephalitis autoimmune | 43.25 | 12.69 | 19 | 30711 | 1277 | 53317059 |
Glossodynia | 43.14 | 12.69 | 4 | 30726 | 100287 | 53218049 |
Respiratory acidosis | 43.09 | 12.69 | 33 | 30697 | 6355 | 53311981 |
Infusion related reaction | 42.98 | 12.69 | 18 | 30712 | 155939 | 53162397 |
Eosinophilia | 42.78 | 12.69 | 57 | 30673 | 21278 | 53297058 |
Contraindicated product administered | 41.88 | 12.69 | 13 | 30717 | 135616 | 53182720 |
Drug level changed | 41.63 | 12.69 | 11 | 30719 | 150 | 53318186 |
Balance disorder | 41.63 | 12.69 | 114 | 30616 | 73093 | 53245243 |
Selective eating disorder | 41.54 | 12.69 | 21 | 30709 | 1937 | 53316399 |
Cytomegalovirus hepatitis | 41.51 | 12.69 | 13 | 30717 | 333 | 53318003 |
Product substitution issue | 40.78 | 12.69 | 48 | 30682 | 15818 | 53302518 |
Discomfort | 40.55 | 12.69 | 4 | 30726 | 95468 | 53222868 |
Acute hepatic failure | 40.37 | 12.69 | 49 | 30681 | 16671 | 53301665 |
Hyperammonaemia | 40.10 | 12.69 | 29 | 30701 | 5120 | 53313216 |
Angiofibroma | 39.73 | 12.69 | 10 | 30720 | 111 | 53318225 |
Foetal death | 39.72 | 12.69 | 37 | 30693 | 9310 | 53309026 |
Oxygen saturation abnormal | 39.28 | 12.69 | 23 | 30707 | 2839 | 53315497 |
Hepatitis | 37.68 | 12.69 | 69 | 30661 | 33825 | 53284511 |
Haemophagocytic lymphohistiocytosis | 36.59 | 12.69 | 35 | 30695 | 9102 | 53309234 |
Lymphangioleiomyomatosis | 35.91 | 12.69 | 10 | 30720 | 168 | 53318168 |
Brain herniation | 35.90 | 12.69 | 23 | 30707 | 3333 | 53315003 |
Nervous system disorder | 35.54 | 12.69 | 47 | 30683 | 17417 | 53300919 |
Somnolence | 34.57 | 12.69 | 189 | 30541 | 167545 | 53150791 |
Angiomyolipoma | 34.51 | 12.69 | 10 | 30720 | 195 | 53318141 |
Overdose | 34.44 | 12.69 | 138 | 30592 | 107598 | 53210738 |
Wound | 33.73 | 12.69 | 6 | 30724 | 91551 | 53226785 |
Myoclonus | 32.97 | 12.69 | 43 | 30687 | 15721 | 53302615 |
Intestinal ischaemia | 32.46 | 12.69 | 30 | 30700 | 7472 | 53310864 |
Pain in extremity | 32.16 | 12.69 | 73 | 30657 | 284977 | 53033359 |
Porphyria | 31.58 | 12.69 | 9 | 30721 | 165 | 53318171 |
Cardiac arrest neonatal | 31.29 | 12.69 | 8 | 30722 | 95 | 53318241 |
Anti-erythropoietin antibody negative | 31.29 | 12.69 | 8 | 30722 | 95 | 53318241 |
Peripheral swelling | 31.14 | 12.69 | 44 | 30686 | 206064 | 53112272 |
Drug intolerance | 30.92 | 12.69 | 44 | 30686 | 205449 | 53112887 |
Laryngeal stenosis | 30.79 | 12.69 | 13 | 30717 | 793 | 53317543 |
Systemic lupus erythematosus | 30.70 | 12.69 | 17 | 30713 | 125397 | 53192939 |
Propofol infusion syndrome | 30.69 | 12.69 | 13 | 30717 | 799 | 53317537 |
Brain injury | 30.44 | 12.69 | 27 | 30703 | 6378 | 53311958 |
Aggression | 30.36 | 12.69 | 51 | 30679 | 23352 | 53294984 |
Myoclonic epilepsy | 30.35 | 12.69 | 14 | 30716 | 1055 | 53317281 |
Hyperreflexia | 29.90 | 12.69 | 25 | 30705 | 5455 | 53312881 |
Seizure cluster | 29.78 | 12.69 | 9 | 30721 | 204 | 53318132 |
Urine copper increased | 29.36 | 12.69 | 5 | 30725 | 4 | 53318332 |
Hypotension | 29.32 | 12.69 | 248 | 30482 | 253828 | 53064508 |
Bronchitis | 29.12 | 12.69 | 14 | 30716 | 111885 | 53206451 |
Nasopharyngitis | 29.10 | 12.69 | 41 | 30689 | 192254 | 53126082 |
Back pain | 28.91 | 12.69 | 57 | 30673 | 234190 | 53084146 |
Urine delta aminolevulinate increased | 28.84 | 12.69 | 5 | 30725 | 5 | 53318331 |
Aura | 27.98 | 12.69 | 13 | 30717 | 996 | 53317340 |
Asthma | 27.80 | 12.69 | 14 | 30716 | 108958 | 53209378 |
Ultrasound ovary abnormal | 27.63 | 12.69 | 7 | 30723 | 80 | 53318256 |
Drug level fluctuating | 27.51 | 12.69 | 10 | 30720 | 408 | 53317928 |
Psoriasis | 27.51 | 12.69 | 8 | 30722 | 87081 | 53231255 |
Depressed level of consciousness | 27.28 | 12.69 | 81 | 30649 | 54347 | 53263989 |
Atonic seizures | 26.94 | 12.69 | 11 | 30719 | 616 | 53317720 |
Bradyarrhythmia | 26.94 | 12.69 | 16 | 30714 | 2027 | 53316309 |
Dermatitis exfoliative | 26.19 | 12.69 | 24 | 30706 | 5912 | 53312424 |
Mental status changes | 25.94 | 12.69 | 65 | 30665 | 39506 | 53278830 |
Coordination abnormal | 25.62 | 12.69 | 33 | 30697 | 11918 | 53306418 |
Abdominal pain upper | 25.61 | 12.69 | 35 | 30695 | 166256 | 53152080 |
Cerebral atrophy | 25.60 | 12.69 | 22 | 30708 | 4982 | 53313354 |
Ischaemic cerebral infarction | 24.76 | 12.69 | 13 | 30717 | 1297 | 53317039 |
Abdominal pain | 24.63 | 12.69 | 71 | 30659 | 255832 | 53062504 |
Malabsorption | 24.55 | 12.69 | 20 | 30710 | 4208 | 53314128 |
Rash morbilliform | 24.55 | 12.69 | 18 | 30712 | 3245 | 53315091 |
Dehydration | 24.40 | 12.69 | 37 | 30693 | 168373 | 53149963 |
Hyperammonaemic encephalopathy | 24.31 | 12.69 | 15 | 30715 | 2036 | 53316300 |
Clonus | 24.29 | 12.69 | 20 | 30710 | 4271 | 53314065 |
Oropharyngeal oedema | 24.22 | 12.69 | 8 | 30722 | 244 | 53318092 |
Vomiting projectile | 24.01 | 12.69 | 13 | 30717 | 1380 | 53316956 |
Ophthalmoplegia | 23.66 | 12.69 | 12 | 30718 | 1115 | 53317221 |
Hypertension | 23.61 | 12.69 | 60 | 30670 | 225371 | 53092965 |
Musculoskeletal pain | 23.58 | 12.69 | 7 | 30723 | 75193 | 53243143 |
Drug level above therapeutic | 23.46 | 12.69 | 19 | 30711 | 3965 | 53314371 |
Speech disorder | 23.25 | 12.69 | 62 | 30668 | 39119 | 53279217 |
Petit mal epilepsy | 23.21 | 12.69 | 18 | 30712 | 3530 | 53314806 |
Lymphadenopathy | 23.18 | 12.69 | 59 | 30671 | 36196 | 53282140 |
Osteoarthritis | 23.15 | 12.69 | 6 | 30724 | 70480 | 53247856 |
Confusional state | 23.14 | 12.69 | 191 | 30539 | 194030 | 53124306 |
Injection site erythema | 22.79 | 12.69 | 8 | 30722 | 77241 | 53241095 |
Lower respiratory tract infection | 22.74 | 12.69 | 12 | 30718 | 90969 | 53227367 |
Creutzfeldt-Jakob disease | 22.63 | 12.69 | 6 | 30724 | 83 | 53318253 |
Porphyrins stool increased | 22.59 | 12.69 | 5 | 30725 | 30 | 53318306 |
Left ventricular dysfunction | 22.49 | 12.69 | 30 | 30700 | 11207 | 53307129 |
Product dose omission issue | 22.47 | 12.69 | 48 | 30682 | 191572 | 53126764 |
Paranoia | 22.10 | 12.69 | 30 | 30700 | 11394 | 53306942 |
Pericarditis | 22.10 | 12.69 | 5 | 30725 | 64401 | 53253935 |
Unresponsive to stimuli | 22.00 | 12.69 | 55 | 30675 | 33371 | 53284965 |
Chest pain | 22.00 | 12.69 | 48 | 30682 | 190137 | 53128199 |
Autism spectrum disorder | 21.96 | 12.69 | 10 | 30720 | 732 | 53317604 |
Perforation | 21.73 | 12.69 | 11 | 30719 | 1018 | 53317318 |
Systemic inflammatory response syndrome | 21.38 | 12.69 | 21 | 30709 | 5639 | 53312697 |
Arthritis | 21.12 | 12.69 | 12 | 30718 | 87286 | 53231050 |
Enterocolitis | 20.95 | 12.69 | 23 | 30707 | 7029 | 53311307 |
Palpitations | 20.84 | 12.69 | 17 | 30713 | 102331 | 53216005 |
Plasmodium falciparum infection | 20.52 | 12.69 | 5 | 30725 | 48 | 53318288 |
Encephalitis | 20.36 | 12.69 | 24 | 30706 | 7920 | 53310416 |
Chronic graft versus host disease | 20.30 | 12.69 | 16 | 30714 | 3212 | 53315124 |
Torticollis | 20.21 | 12.69 | 13 | 30717 | 1897 | 53316439 |
Pyrexia | 20.14 | 12.69 | 335 | 30395 | 402858 | 52915478 |
Calcinosis | 20.11 | 12.69 | 13 | 30717 | 1913 | 53316423 |
Malaise | 19.68 | 12.69 | 123 | 30607 | 357494 | 52960842 |
Hypotonia | 19.65 | 12.69 | 25 | 30705 | 8916 | 53309420 |
Cerebellar cognitive affective syndrome | 19.38 | 12.69 | 3 | 30727 | 0 | 53318336 |
Blood alkaline phosphatase increased | 19.26 | 12.69 | 60 | 30670 | 41302 | 53277034 |
Ammonia increased | 19.23 | 12.69 | 18 | 30712 | 4555 | 53313781 |
Psychotic disorder | 19.17 | 12.69 | 43 | 30687 | 24342 | 53293994 |
Cross sensitivity reaction | 19.16 | 12.69 | 13 | 30717 | 2074 | 53316262 |
Aplasia pure red cell | 19.15 | 12.69 | 18 | 30712 | 4578 | 53313758 |
Cognitive disorder | 19.08 | 12.69 | 63 | 30667 | 44715 | 53273621 |
Areflexia | 18.99 | 12.69 | 15 | 30715 | 3021 | 53315315 |
Euthyroid sick syndrome | 18.87 | 12.69 | 5 | 30725 | 69 | 53318267 |
Adverse drug reaction | 18.72 | 12.69 | 4 | 30726 | 53621 | 53264715 |
Intensive care unit acquired weakness | 18.72 | 12.69 | 9 | 30721 | 745 | 53317591 |
Altered state of consciousness | 18.64 | 12.69 | 43 | 30687 | 24793 | 53293543 |
Blood magnesium decreased | 18.42 | 12.69 | 28 | 30702 | 11786 | 53306550 |
Mucosal erosion | 18.27 | 12.69 | 11 | 30719 | 1428 | 53316908 |
Muscle spasms | 18.22 | 12.69 | 31 | 30699 | 134764 | 53183572 |
Chorea | 18.22 | 12.69 | 11 | 30719 | 1436 | 53316900 |
Psoriatic arthropathy | 18.09 | 12.69 | 3 | 30727 | 48187 | 53270149 |
Illusion | 18.09 | 12.69 | 10 | 30720 | 1106 | 53317230 |
Linear IgA disease | 18.06 | 12.69 | 11 | 30719 | 1459 | 53316877 |
Gamma-glutamyltransferase increased | 17.83 | 12.69 | 51 | 30679 | 33504 | 53284832 |
Hypersensitivity | 17.77 | 12.69 | 62 | 30668 | 210603 | 53107733 |
Disease recurrence | 17.67 | 12.69 | 38 | 30692 | 20908 | 53297428 |
Idiopathic pneumonia syndrome | 17.62 | 12.69 | 7 | 30723 | 365 | 53317971 |
Weight increased | 17.39 | 12.69 | 60 | 30670 | 204507 | 53113829 |
Loss of consciousness | 17.36 | 12.69 | 119 | 30611 | 114093 | 53204243 |
Intention tremor | 17.35 | 12.69 | 7 | 30723 | 380 | 53317956 |
Rasmussen encephalitis | 17.30 | 12.69 | 3 | 30727 | 3 | 53318333 |
Neonatal seizure | 17.25 | 12.69 | 7 | 30723 | 386 | 53317950 |
Left ventricular hypertrophy | 17.21 | 12.69 | 18 | 30712 | 5205 | 53313131 |
Ventricular dysfunction | 17.17 | 12.69 | 14 | 30716 | 2949 | 53315387 |
Incoherent | 17.03 | 12.69 | 17 | 30713 | 4655 | 53313681 |
Swelling | 16.97 | 12.69 | 55 | 30675 | 191050 | 53127286 |
Intestinal dilatation | 16.96 | 12.69 | 11 | 30719 | 1627 | 53316709 |
Cardiac arrest | 16.95 | 12.69 | 102 | 30628 | 93565 | 53224771 |
Lip erosion | 16.87 | 12.69 | 9 | 30721 | 928 | 53317408 |
Posterior reversible encephalopathy syndrome | 16.83 | 12.69 | 32 | 30698 | 16128 | 53302208 |
Influenza like illness | 16.79 | 12.69 | 7 | 30723 | 60852 | 53257484 |
Cerebellar syndrome | 16.73 | 12.69 | 15 | 30715 | 3592 | 53314744 |
CSF oligoclonal band present | 16.60 | 12.69 | 5 | 30725 | 112 | 53318224 |
Asterixis | 16.50 | 12.69 | 10 | 30720 | 1314 | 53317022 |
Hallucination, tactile | 16.45 | 12.69 | 6 | 30724 | 247 | 53318089 |
Epileptic psychosis | 16.27 | 12.69 | 4 | 30726 | 40 | 53318296 |
Medication error | 16.24 | 12.69 | 52 | 30678 | 36313 | 53282023 |
Intensive care unit delirium | 16.18 | 12.69 | 4 | 30726 | 41 | 53318295 |
Drug withdrawal convulsions | 16.17 | 12.69 | 10 | 30720 | 1362 | 53316974 |
Musculoskeletal stiffness | 16.10 | 12.69 | 29 | 30701 | 123339 | 53194997 |
Oromandibular dystonia | 15.90 | 12.69 | 7 | 30723 | 473 | 53317863 |
Lactose intolerance | 15.82 | 12.69 | 13 | 30717 | 2768 | 53315568 |
Hirsutism | 15.76 | 12.69 | 9 | 30721 | 1059 | 53317277 |
Lethargy | 15.70 | 12.69 | 67 | 30663 | 53693 | 53264643 |
Constipation | 15.67 | 12.69 | 60 | 30670 | 198352 | 53119984 |
Cachexia | 15.61 | 12.69 | 17 | 30713 | 5147 | 53313189 |
Hospitalisation | 15.47 | 12.69 | 11 | 30719 | 71001 | 53247335 |
Herpes zoster | 15.44 | 12.69 | 12 | 30718 | 74007 | 53244329 |
Epileptic encephalopathy | 15.44 | 12.69 | 6 | 30724 | 295 | 53318041 |
Magnetic resonance imaging head abnormal | 15.39 | 12.69 | 11 | 30719 | 1907 | 53316429 |
Chest discomfort | 15.32 | 12.69 | 21 | 30709 | 99674 | 53218662 |
Injection site swelling | 15.26 | 12.69 | 3 | 30727 | 42625 | 53275711 |
Periorbital oedema | 15.21 | 12.69 | 17 | 30713 | 5298 | 53313038 |
Enzyme induction | 15.04 | 12.69 | 4 | 30726 | 56 | 53318280 |
Infrequent bowel movements | 14.74 | 12.69 | 9 | 30721 | 1199 | 53317137 |
Potentiating drug interaction | 14.63 | 12.69 | 15 | 30715 | 4238 | 53314098 |
Abnormal behaviour | 14.41 | 12.69 | 36 | 30694 | 21830 | 53296506 |
Weight decreased | 14.41 | 12.69 | 78 | 30652 | 234870 | 53083466 |
Hallucination, auditory | 14.40 | 12.69 | 25 | 30705 | 11748 | 53306588 |
Low birth weight baby | 14.37 | 12.69 | 18 | 30712 | 6319 | 53312017 |
Hypoventilation | 14.35 | 12.69 | 15 | 30715 | 4334 | 53314002 |
Haemodynamic instability | 14.30 | 12.69 | 21 | 30709 | 8573 | 53309763 |
Tachycardia | 14.29 | 12.69 | 109 | 30621 | 108103 | 53210233 |
Gastrooesophageal reflux disease | 14.18 | 12.69 | 16 | 30714 | 82647 | 53235689 |
Dyspnoea exertional | 14.12 | 12.69 | 7 | 30723 | 54993 | 53263343 |
Hypersensitivity vasculitis | 14.09 | 12.69 | 15 | 30715 | 4428 | 53313908 |
Biopsy brain | 14.01 | 12.69 | 3 | 30727 | 15 | 53318321 |
Tongue ulceration | 13.99 | 12.69 | 13 | 30717 | 3259 | 53315077 |
Coagulation time prolonged | 13.98 | 12.69 | 9 | 30721 | 1315 | 53317021 |
Impaired healing | 13.92 | 12.69 | 10 | 30720 | 64195 | 53254141 |
Coma scale abnormal | 13.86 | 12.69 | 16 | 30714 | 5162 | 53313174 |
Dystonia | 13.83 | 12.69 | 26 | 30704 | 12995 | 53305341 |
Cough | 13.78 | 12.69 | 89 | 30641 | 256804 | 53061532 |
Influenza | 13.76 | 12.69 | 21 | 30709 | 95358 | 53222978 |
Respiratory failure | 13.69 | 12.69 | 102 | 30628 | 100410 | 53217926 |
Diabetes mellitus | 13.63 | 12.69 | 7 | 30723 | 53892 | 53264444 |
Myalgia | 13.60 | 12.69 | 36 | 30694 | 133455 | 53184881 |
Brain neoplasm | 13.34 | 12.69 | 14 | 30716 | 4064 | 53314272 |
Intentional overdose | 13.34 | 12.69 | 75 | 30655 | 67130 | 53251206 |
Anaemia | 13.30 | 12.69 | 99 | 30631 | 276619 | 53041717 |
Oedema peripheral | 13.26 | 12.69 | 52 | 30678 | 170735 | 53147601 |
Central nervous system infection | 13.18 | 12.69 | 7 | 30723 | 715 | 53317621 |
Allodynia | 13.15 | 12.69 | 7 | 30723 | 718 | 53317618 |
Impaired self-care | 13.06 | 12.69 | 10 | 30720 | 1925 | 53316411 |
Post-traumatic epilepsy | 13.03 | 12.69 | 3 | 30727 | 22 | 53318314 |
Drug level abnormal | 12.98 | 12.69 | 4 | 30726 | 97 | 53318239 |
Pyroglutamate increased | 12.91 | 12.69 | 6 | 30724 | 460 | 53317876 |
Behaviour disorder | 12.81 | 12.69 | 11 | 30719 | 2489 | 53315847 |
Injection site pruritus | 12.80 | 12.69 | 4 | 30726 | 41585 | 53276751 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Seizure | 1534.95 | 13.15 | 1022 | 28116 | 102832 | 32381556 |
Status epilepticus | 832.87 | 13.15 | 336 | 28802 | 11670 | 32472718 |
Nystagmus | 664.97 | 13.15 | 222 | 28916 | 4440 | 32479948 |
Toxicity to various agents | 595.29 | 13.15 | 762 | 28376 | 177279 | 32307109 |
Anticonvulsant drug level increased | 569.34 | 13.15 | 153 | 28985 | 1385 | 32483003 |
Drug reaction with eosinophilia and systemic symptoms | 523.96 | 13.15 | 339 | 28799 | 32146 | 32452242 |
Ataxia | 497.12 | 13.15 | 238 | 28900 | 12503 | 32471885 |
Anticonvulsant drug level above therapeutic | 374.98 | 13.15 | 88 | 29050 | 425 | 32483963 |
Anticonvulsant drug level decreased | 298.25 | 13.15 | 84 | 29054 | 918 | 32483470 |
Generalised tonic-clonic seizure | 276.28 | 13.15 | 192 | 28946 | 20447 | 32463941 |
Drug interaction | 260.94 | 13.15 | 591 | 28547 | 217594 | 32266794 |
Epilepsy | 211.31 | 13.15 | 168 | 28970 | 21941 | 32462447 |
Cerebellar atrophy | 178.58 | 13.15 | 48 | 29090 | 434 | 32483954 |
Stevens-Johnson syndrome | 176.27 | 13.15 | 141 | 28997 | 18568 | 32465820 |
Anticonvulsant drug level below therapeutic | 164.38 | 13.15 | 48 | 29090 | 602 | 32483786 |
Drug level decreased | 163.04 | 13.15 | 90 | 29048 | 6356 | 32478032 |
Partial seizures | 145.15 | 13.15 | 72 | 29066 | 4078 | 32480310 |
Drug ineffective | 129.69 | 13.15 | 680 | 28458 | 382797 | 32101591 |
Diarrhoea | 121.81 | 13.15 | 90 | 29048 | 364712 | 32119676 |
Drug hypersensitivity | 120.40 | 13.15 | 227 | 28911 | 73173 | 32411215 |
Purple glove syndrome | 114.93 | 13.15 | 23 | 29115 | 41 | 32484347 |
Dysarthria | 108.33 | 13.15 | 141 | 28997 | 33060 | 32451328 |
Multiple-drug resistance | 107.42 | 13.15 | 57 | 29081 | 3718 | 32480670 |
Dyspnoea | 104.12 | 13.15 | 103 | 29035 | 361942 | 32122446 |
Hyperammonaemia | 102.74 | 13.15 | 65 | 29073 | 5904 | 32478484 |
Gingival hypertrophy | 95.57 | 13.15 | 41 | 29097 | 1658 | 32482730 |
Drug resistance | 93.42 | 13.15 | 109 | 29029 | 22856 | 32461532 |
Drug level fluctuating | 91.22 | 13.15 | 29 | 29109 | 492 | 32483896 |
Sudden unexplained death in epilepsy | 89.83 | 13.15 | 28 | 29110 | 444 | 32483944 |
Drug level below therapeutic | 88.40 | 13.15 | 52 | 29086 | 4143 | 32480245 |
Drug level increased | 87.90 | 13.15 | 99 | 29039 | 19981 | 32464407 |
Product complaint | 82.33 | 13.15 | 56 | 29082 | 5747 | 32478641 |
Coordination abnormal | 78.55 | 13.15 | 61 | 29077 | 7687 | 32476701 |
Drug level above therapeutic | 70.04 | 13.15 | 41 | 29097 | 3237 | 32481151 |
Anaemia | 68.39 | 13.15 | 60 | 29078 | 223564 | 32260824 |
Sedation | 64.05 | 13.15 | 81 | 29057 | 18445 | 32465943 |
Brain oedema | 62.08 | 13.15 | 67 | 29071 | 12893 | 32471495 |
Foetal anticonvulsant syndrome | 61.22 | 13.15 | 26 | 29112 | 1025 | 32483363 |
Gait disturbance | 59.83 | 13.15 | 183 | 28955 | 80225 | 32404163 |
Cerebellar syndrome | 59.64 | 13.15 | 32 | 29106 | 2134 | 32482254 |
Confusional state | 57.36 | 13.15 | 267 | 28871 | 142848 | 32341540 |
Mental status changes | 56.00 | 13.15 | 113 | 29025 | 38224 | 32446164 |
Somnolence | 55.90 | 13.15 | 212 | 28926 | 103585 | 32380803 |
Depressed level of consciousness | 54.51 | 13.15 | 116 | 29022 | 40731 | 32443657 |
Acute kidney injury | 54.09 | 13.15 | 114 | 29024 | 293354 | 32191034 |
Intensive care unit acquired weakness | 53.61 | 13.15 | 23 | 29115 | 930 | 32483458 |
Pain | 51.86 | 13.15 | 55 | 29083 | 187501 | 32296887 |
Arthralgia | 51.47 | 13.15 | 35 | 29103 | 148413 | 32335975 |
Rash maculo-papular | 51.35 | 13.15 | 91 | 29047 | 27931 | 32456457 |
Toxic epidermal necrolysis | 50.08 | 13.15 | 76 | 29062 | 20517 | 32463871 |
Chest pain | 49.06 | 13.15 | 25 | 29113 | 124112 | 32360276 |
Fatigue | 48.05 | 13.15 | 158 | 28980 | 350543 | 32133845 |
Urine copper increased | 47.94 | 13.15 | 9 | 29129 | 9 | 32484379 |
Anticonvulsant drug level abnormal | 47.40 | 13.15 | 10 | 29128 | 26 | 32484362 |
Febrile neutropenia | 45.88 | 13.15 | 25 | 29113 | 119541 | 32364847 |
Cerebellar ataxia | 45.59 | 13.15 | 21 | 29117 | 1007 | 32483381 |
Myocardial infarction | 44.40 | 13.15 | 29 | 29109 | 125647 | 32358741 |
Cough | 42.67 | 13.15 | 37 | 29101 | 138780 | 32345608 |
Completed suicide | 42.61 | 13.15 | 180 | 28958 | 92337 | 32392051 |
Death | 41.68 | 13.15 | 189 | 28949 | 382328 | 32102060 |
Cross sensitivity reaction | 41.41 | 13.15 | 22 | 29116 | 1438 | 32482950 |
Hypotonia | 40.84 | 13.15 | 42 | 29096 | 7645 | 32476743 |
Lethargy | 40.65 | 13.15 | 104 | 29034 | 41124 | 32443264 |
Drug level changed | 39.26 | 13.15 | 14 | 29124 | 342 | 32484046 |
Myalgia | 39.23 | 13.15 | 12 | 29126 | 81218 | 32403170 |
Dehydration | 38.87 | 13.15 | 35 | 29103 | 128923 | 32355465 |
Stupor | 37.91 | 13.15 | 27 | 29111 | 2982 | 32481406 |
Asterixis | 37.80 | 13.15 | 20 | 29118 | 1296 | 32483092 |
Encephalopathy | 37.56 | 13.15 | 90 | 29048 | 34167 | 32450221 |
Porphyrins stool increased | 37.28 | 13.15 | 7 | 29131 | 7 | 32484381 |
Pneumonia | 36.63 | 13.15 | 179 | 28959 | 355073 | 32129315 |
Necrosis ischaemic | 36.48 | 13.15 | 12 | 29126 | 228 | 32484160 |
Petit mal epilepsy | 36.39 | 13.15 | 26 | 29112 | 2886 | 32481502 |
Diabetes insipidus | 36.39 | 13.15 | 25 | 29113 | 2607 | 32481781 |
Cerebral atrophy | 36.11 | 13.15 | 31 | 29107 | 4496 | 32479892 |
Choreoathetosis | 36.05 | 13.15 | 18 | 29120 | 1033 | 32483355 |
Blood homocysteine increased | 35.13 | 13.15 | 12 | 29126 | 257 | 32484131 |
Postictal paralysis | 34.74 | 13.15 | 11 | 29127 | 184 | 32484204 |
Gaze palsy | 34.41 | 13.15 | 19 | 29119 | 1341 | 32483047 |
Hyperammonaemic encephalopathy | 34.26 | 13.15 | 22 | 29116 | 2049 | 32482339 |
Dysmetria | 34.20 | 13.15 | 13 | 29125 | 382 | 32484006 |
Inhibitory drug interaction | 33.91 | 13.15 | 20 | 29118 | 1601 | 32482787 |
Acidosis hyperchloraemic | 33.81 | 13.15 | 12 | 29126 | 289 | 32484099 |
Balance disorder | 33.32 | 13.15 | 94 | 29044 | 39365 | 32445023 |
Ophthalmoplegia | 33.26 | 13.15 | 19 | 29119 | 1432 | 32482956 |
Hypoplastic left heart syndrome | 32.50 | 13.15 | 11 | 29127 | 229 | 32484159 |
Hippocampal sclerosis | 32.23 | 13.15 | 9 | 29129 | 95 | 32484293 |
Focal dyscognitive seizures | 31.93 | 13.15 | 18 | 29120 | 1323 | 32483065 |
Nausea | 31.72 | 13.15 | 164 | 28974 | 320685 | 32163703 |
Extensor plantar response | 31.67 | 13.15 | 14 | 29124 | 609 | 32483779 |
Dystonia | 31.37 | 13.15 | 43 | 29095 | 10580 | 32473808 |
Cardiac failure | 31.23 | 13.15 | 22 | 29116 | 91651 | 32392737 |
Hyperreflexia | 31.21 | 13.15 | 24 | 29114 | 2980 | 32481408 |
Idiosyncratic drug reaction | 31.08 | 13.15 | 13 | 29125 | 493 | 32483895 |
Overdose | 30.90 | 13.15 | 157 | 28981 | 86920 | 32397468 |
Malaise | 30.75 | 13.15 | 71 | 29067 | 177067 | 32307321 |
Erythema multiforme | 30.57 | 13.15 | 39 | 29099 | 8953 | 32475435 |
Product substitution issue | 30.46 | 13.15 | 42 | 29096 | 10394 | 32473994 |
Chills | 30.42 | 13.15 | 16 | 29122 | 78068 | 32406320 |
Past-pointing | 30.13 | 13.15 | 7 | 29131 | 32 | 32484356 |
Unresponsive to stimuli | 29.69 | 13.15 | 72 | 29066 | 27537 | 32456851 |
Drug withdrawal convulsions | 28.62 | 13.15 | 16 | 29122 | 1157 | 32483231 |
Fall | 28.20 | 13.15 | 284 | 28854 | 195917 | 32288471 |
Joint swelling | 28.12 | 13.15 | 6 | 29132 | 51729 | 32432659 |
Cardiac failure congestive | 28.07 | 13.15 | 21 | 29117 | 84831 | 32399557 |
Intention tremor | 27.91 | 13.15 | 11 | 29127 | 357 | 32484031 |
Oedema peripheral | 27.71 | 13.15 | 37 | 29101 | 114054 | 32370334 |
Blood albumin decreased | 27.60 | 13.15 | 45 | 29093 | 12908 | 32471480 |
Abdominal pain | 27.53 | 13.15 | 58 | 29080 | 149471 | 32334917 |
Interstitial lung disease | 27.33 | 13.15 | 12 | 29126 | 64989 | 32419399 |
Atrial fibrillation | 27.19 | 13.15 | 39 | 29099 | 116665 | 32367723 |
Intestinal ischaemia | 26.99 | 13.15 | 33 | 29105 | 7258 | 32477130 |
Back pain | 26.99 | 13.15 | 36 | 29102 | 111017 | 32373371 |
Aggression | 26.82 | 13.15 | 87 | 29051 | 39302 | 32445086 |
Atonic seizures | 26.74 | 13.15 | 9 | 29129 | 184 | 32484204 |
Pain in extremity | 26.47 | 13.15 | 41 | 29097 | 118860 | 32365528 |
Labelled drug-drug interaction medication error | 26.28 | 13.15 | 43 | 29095 | 12370 | 32472018 |
Constipation | 25.89 | 13.15 | 46 | 29092 | 126327 | 32358061 |
Eosinophilia | 25.68 | 13.15 | 64 | 29074 | 24894 | 32459494 |
Superinfection | 25.62 | 13.15 | 18 | 29120 | 1946 | 32482442 |
Coagulopathy | 25.41 | 13.15 | 55 | 29083 | 19522 | 32464866 |
Aura | 25.36 | 13.15 | 10 | 29128 | 325 | 32484063 |
Neonatal respiratory depression | 25.33 | 13.15 | 11 | 29127 | 458 | 32483930 |
Postictal psychosis | 25.15 | 13.15 | 8 | 29130 | 136 | 32484252 |
Haemophagocytic lymphohistiocytosis | 25.00 | 13.15 | 40 | 29098 | 11295 | 32473093 |
Hyperchloraemia | 24.94 | 13.15 | 11 | 29127 | 476 | 32483912 |
Gamma-glutamyltransferase increased | 24.69 | 13.15 | 72 | 29066 | 30710 | 32453678 |
Macule | 24.68 | 13.15 | 14 | 29124 | 1041 | 32483347 |
Asthma | 24.18 | 13.15 | 5 | 29133 | 44060 | 32440328 |
Haemoglobin decreased | 24.11 | 13.15 | 44 | 29094 | 119627 | 32364761 |
Autonomic nervous system imbalance | 23.47 | 13.15 | 19 | 29119 | 2541 | 32481847 |
Gingival disorder | 23.12 | 13.15 | 15 | 29123 | 1422 | 32482966 |
Blood glucose increased | 23.09 | 13.15 | 15 | 29123 | 65226 | 32419162 |
Gingival atrophy | 23.08 | 13.15 | 6 | 29132 | 47 | 32484341 |
Simple partial seizures | 23.07 | 13.15 | 9 | 29129 | 284 | 32484104 |
Porphyria acute | 22.82 | 13.15 | 7 | 29131 | 105 | 32484283 |
Obliterative bronchiolitis | 22.76 | 13.15 | 14 | 29124 | 1209 | 32483179 |
Hepatitis fulminant | 22.66 | 13.15 | 23 | 29115 | 4120 | 32480268 |
Excessive eye blinking | 22.66 | 13.15 | 10 | 29128 | 433 | 32483955 |
Diplopia | 22.65 | 13.15 | 44 | 29094 | 14468 | 32469920 |
Muscle twitching | 22.18 | 13.15 | 33 | 29105 | 8751 | 32475637 |
Impetigo | 21.84 | 13.15 | 12 | 29126 | 839 | 32483549 |
Cytokine storm | 21.79 | 13.15 | 11 | 29127 | 646 | 32483742 |
Mucosal erosion | 21.52 | 13.15 | 12 | 29126 | 863 | 32483525 |
Pulmonary embolism | 21.48 | 13.15 | 26 | 29112 | 83633 | 32400755 |
Urine delta aminolevulinate increased | 21.30 | 13.15 | 4 | 29134 | 4 | 32484384 |
Barbiturates positive | 21.30 | 13.15 | 4 | 29134 | 4 | 32484384 |
Vasogenic cerebral oedema | 21.15 | 13.15 | 10 | 29128 | 509 | 32483879 |
Mucosal ulceration | 21.07 | 13.15 | 12 | 29126 | 899 | 32483489 |
Agitation | 20.85 | 13.15 | 104 | 29034 | 57132 | 32427256 |
Intellectual disability | 20.85 | 13.15 | 13 | 29125 | 1150 | 32483238 |
Plasma cell myeloma | 20.73 | 13.15 | 13 | 29125 | 57601 | 32426787 |
Tonic convulsion | 20.37 | 13.15 | 12 | 29126 | 958 | 32483430 |
Hypothermia | 20.05 | 13.15 | 34 | 29104 | 10069 | 32474319 |
Nervous system disorder | 20.01 | 13.15 | 41 | 29097 | 14008 | 32470380 |
Chest discomfort | 19.99 | 13.15 | 10 | 29128 | 50220 | 32434168 |
Acute generalised exanthematous pustulosis | 19.88 | 13.15 | 27 | 29111 | 6586 | 32477802 |
Blood ketone body increased | 19.72 | 13.15 | 9 | 29129 | 422 | 32483966 |
Dyskinesia | 19.70 | 13.15 | 56 | 29082 | 23547 | 32460841 |
General physical health deterioration | 19.34 | 13.15 | 47 | 29091 | 115212 | 32369176 |
Cognitive disorder | 19.28 | 13.15 | 59 | 29079 | 25835 | 32458553 |
Encephalomalacia | 19.25 | 13.15 | 10 | 29128 | 624 | 32483764 |
Haematuria traumatic | 19.01 | 13.15 | 7 | 29131 | 188 | 32484200 |
Glioblastoma multiforme | 18.92 | 13.15 | 11 | 29127 | 857 | 32483531 |
Cerebral palsy | 18.70 | 13.15 | 6 | 29132 | 105 | 32484283 |
Nephritis allergic | 18.62 | 13.15 | 9 | 29129 | 481 | 32483907 |
Propofol infusion syndrome | 18.55 | 13.15 | 11 | 29127 | 889 | 32483499 |
Brain herniation | 18.51 | 13.15 | 20 | 29118 | 3851 | 32480537 |
Cardiac arrest | 18.43 | 13.15 | 149 | 28989 | 96627 | 32387761 |
Syncope | 18.27 | 13.15 | 33 | 29105 | 90091 | 32394297 |
Soft tissue swelling | 18.23 | 13.15 | 8 | 29130 | 342 | 32484046 |
Unmasking of previously unidentified disease | 18.20 | 13.15 | 10 | 29128 | 699 | 32483689 |
Methylenetetrahydrofolate reductase deficiency | 18.06 | 13.15 | 3 | 29135 | 0 | 32484388 |
Aphasia | 17.95 | 13.15 | 50 | 29088 | 20778 | 32463610 |
Lymphocyte morphology abnormal | 17.92 | 13.15 | 9 | 29129 | 523 | 32483865 |
Anxiety | 17.86 | 13.15 | 37 | 29101 | 95968 | 32388420 |
Ammonia increased | 17.83 | 13.15 | 21 | 29117 | 4443 | 32479945 |
Personality disorder | 17.80 | 13.15 | 12 | 29126 | 1213 | 32483175 |
Areflexia | 17.65 | 13.15 | 17 | 29121 | 2859 | 32481529 |
Injection site pain | 17.63 | 13.15 | 4 | 29134 | 33054 | 32451334 |
Pulmonary vasculitis | 17.59 | 13.15 | 6 | 29132 | 128 | 32484260 |
Neurodegenerative disorder | 17.51 | 13.15 | 7 | 29131 | 236 | 32484152 |
Malabsorption | 17.43 | 13.15 | 15 | 29123 | 2182 | 32482206 |
Mydriasis | 17.41 | 13.15 | 25 | 29113 | 6421 | 32477967 |
Psoriasis | 17.16 | 13.15 | 10 | 29128 | 46113 | 32438275 |
Encephalitis | 17.12 | 13.15 | 26 | 29112 | 7018 | 32477370 |
COVID-19 | 16.82 | 13.15 | 4 | 29134 | 32011 | 32452377 |
Retinal vein occlusion | 16.71 | 13.15 | 13 | 29125 | 1641 | 32482747 |
Malignant neoplasm progression | 16.58 | 13.15 | 28 | 29110 | 78468 | 32405920 |
Learning disorder | 16.45 | 13.15 | 10 | 29128 | 846 | 32483542 |
Acute hepatic failure | 16.33 | 13.15 | 36 | 29102 | 12933 | 32471455 |
White blood cell count decreased | 16.25 | 13.15 | 36 | 29102 | 91162 | 32393226 |
Dysmorphism | 16.19 | 13.15 | 16 | 29122 | 2777 | 32481611 |
Ascites | 16.00 | 13.15 | 8 | 29130 | 40183 | 32444205 |
Nasopharyngeal reflux | 15.98 | 13.15 | 3 | 29135 | 3 | 32484385 |
Soft tissue haemorrhage | 15.96 | 13.15 | 6 | 29132 | 171 | 32484217 |
Lymphocytosis | 15.88 | 13.15 | 14 | 29124 | 2103 | 32482285 |
Rash morbilliform | 15.85 | 13.15 | 16 | 29122 | 2848 | 32481540 |
Drug ineffective for unapproved indication | 15.73 | 13.15 | 37 | 29101 | 13875 | 32470513 |
Pneumonitis | 15.38 | 13.15 | 4 | 29134 | 30130 | 32454258 |
Intracranial pressure increased | 15.33 | 13.15 | 18 | 29120 | 3795 | 32480593 |
Familial periodic paralysis | 15.20 | 13.15 | 5 | 29133 | 95 | 32484293 |
Muscle spasms | 14.98 | 13.15 | 25 | 29113 | 70393 | 32413995 |
Hyperkinesia | 14.98 | 13.15 | 14 | 29124 | 2268 | 32482120 |
Feeling of despair | 14.84 | 13.15 | 10 | 29128 | 1010 | 32483378 |
Chemical burn | 14.69 | 13.15 | 6 | 29132 | 214 | 32484174 |
Phalangeal hypoplasia | 14.45 | 13.15 | 3 | 29135 | 7 | 32484381 |
Hypertension | 14.32 | 13.15 | 65 | 29073 | 131685 | 32352703 |
Open angle glaucoma | 14.19 | 13.15 | 6 | 29132 | 234 | 32484154 |
Ischaemic hepatitis | 14.18 | 13.15 | 12 | 29126 | 1707 | 32482681 |
Chorea | 14.12 | 13.15 | 10 | 29128 | 1095 | 32483293 |
Pancytopenia | 13.92 | 13.15 | 39 | 29099 | 91196 | 32393192 |
Lid lag | 13.90 | 13.15 | 3 | 29135 | 9 | 32484379 |
Orthostatic hypotension | 13.89 | 13.15 | 3 | 29135 | 25647 | 32458741 |
Coma | 13.83 | 13.15 | 75 | 29063 | 42537 | 32441851 |
Prescribed overdose | 13.82 | 13.15 | 28 | 29110 | 9491 | 32474897 |
Neurotoxicity | 13.80 | 13.15 | 37 | 29101 | 15033 | 32469355 |
Gastrooesophageal reflux disease | 13.70 | 13.15 | 7 | 29131 | 34731 | 32449657 |
Epistaxis | 13.66 | 13.15 | 18 | 29120 | 55837 | 32428551 |
Symblepharon | 13.59 | 13.15 | 5 | 29133 | 134 | 32484254 |
Posture abnormal | 13.53 | 13.15 | 13 | 29125 | 2180 | 32482208 |
Maternal exposure during pregnancy | 13.42 | 13.15 | 18 | 29120 | 4339 | 32480049 |
Streptococcus test positive | 13.38 | 13.15 | 9 | 29129 | 906 | 32483482 |
Treatment noncompliance | 13.34 | 13.15 | 54 | 29084 | 27148 | 32457240 |
Prostate cancer | 13.31 | 13.15 | 4 | 29134 | 27402 | 32456986 |
Bone metabolism disorder | 13.28 | 13.15 | 6 | 29132 | 275 | 32484113 |
Coronary artery disease | 13.23 | 13.15 | 15 | 29123 | 49691 | 32434697 |
Apallic syndrome | 13.20 | 13.15 | 6 | 29132 | 279 | 32484109 |
Weight decreased | 13.18 | 13.15 | 90 | 29048 | 164728 | 32319660 |
Source | Code | Description |
---|---|---|
ATC | N03AB02 | NERVOUS SYSTEM ANTIEPILEPTICS ANTIEPILEPTICS Hydantoin derivatives |
ATC | N03AB52 | NERVOUS SYSTEM ANTIEPILEPTICS ANTIEPILEPTICS Hydantoin derivatives |
FDA PE | N0000008486 | Decreased Central Nervous System Disorganized Electrical Activity |
MeSH PA | D000927 | Anticonvulsants |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D065694 | Cytochrome P-450 CYP1A2 Inducers |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D065606 | Metabolic Side Effects of Drugs and Substances |
MeSH PA | D026941 | Sodium Channel Blockers |
MeSH PA | D061567 | Voltage-Gated Sodium Channel Blockers |
CHEBI has role | CHEBI:35623 | antiepileptic |
CHEBI has role | CHEBI:38633 | Na channel blocker |
CHEBI has role | CHEBI:50905 | teratogen |
CHEBI has role | CHEBI:88188 | allergenic drug |
FDA EPC | N0000175753 | Anti-epileptic Agent |
FDA MoA | N0000185507 | Cytochrome P450 2C9 Inducers |
FDA MoA | N0000185607 | Cytochrome P450 2C19 Inducers |
FDA MoA | N0000187063 | Cytochrome P450 2C8 Inducers |
FDA MoA | N0000187064 | Cytochrome P450 2B6 Inducers |
FDA MoA | N0000190118 | Cytochrome P450 3A Inducers |
FDA MoA | N0000191266 | Cytochrome P450 1A2 Inducers |
FDA MoA | N0000191267 | Cytochrome P450 2D6 Inducers |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Tonic-clonic seizure | indication | 54200006 | |
Epilepsy | indication | 84757009 | DOID:1826 |
Bipolar disorder in remission | indication | 85248005 | |
Localization-related epilepsy | indication | 230381009 | DOID:2234 |
Lennox-Gastaut syndrome | indication | 230418006 | |
Status epilepticus | indication | 230456007 | DOID:1824 |
Motor cortex epilepsy | indication | 267592003 | |
Tonic-clonic epilepsy | indication | 352818000 | DOID:7725 |
Epilepsy characterized by intractable complex partial seizures | indication | 442481002 | |
Simple partial seizure | indication | 117891000119100 | |
Seizures in Neurosurgery | indication | ||
Prevention of Seizures following Cranial Trauma or Surgery | indication | ||
Bipolar affective disorder, current episode depression | off-label use | 191627008 | DOID:3312 |
Wound care | off-label use | 225358003 | |
Neuropathic pain | off-label use | 247398009 | |
Rapid Cycling Bipolar Affective Disorder | off-label use | ||
Osteomalacia | contraindication | 4598005 | DOID:10573 |
Suicidal thoughts | contraindication | 6471006 | |
Alcoholism | contraindication | 7200002 | |
Hyperammonemia | contraindication | 9360008 | |
Hepatic encephalopathy | contraindication | 13920009 | DOID:13413 |
Disorder of thyroid gland | contraindication | 14304000 | DOID:50 |
Agranulocytosis | contraindication | 17182001 | DOID:12987 |
Hyperphosphatemia | contraindication | 20165001 | DOID:0050459 |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Alcohol intoxication | contraindication | 25702006 | |
Complete atrioventricular block | contraindication | 27885002 | |
Lymphadenopathy | contraindication | 30746006 | |
Torsades de pointes | contraindication | 31722008 | |
Depressive disorder | contraindication | 35489007 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Low blood pressure | contraindication | 45007003 | |
Stokes-Adams syndrome | contraindication | 46935006 | |
Sinus bradycardia | contraindication | 49710005 | |
Megaloblastic anemia | contraindication | 53165003 | DOID:13382 |
Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Sinus node dysfunction | contraindication | 60423000 | |
Poisoning by phenobarbital | contraindication | 64921004 | |
Substance abuse | contraindication | 66214007 | |
Hepatic coma | contraindication | 72836002 | DOID:12550 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Sleep apnea | contraindication | 73430006 | DOID:0050847 |
Hyperglycemia | contraindication | 80394007 | DOID:4195 |
Decreased respiratory function | contraindication | 80954004 | |
Leukopenia | contraindication | 84828003 | DOID:615 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Prolonged QT interval | contraindication | 111975006 | |
Hypoalbuminemia | contraindication | 119247004 | |
Pancytopenia | contraindication | 127034005 | DOID:12450 |
Purple glove syndrome | contraindication | 129576003 | |
Second degree atrioventricular block | contraindication | 195042002 | |
Decompensated cardiac failure | contraindication | 195111005 | |
Non-infective meningitis | contraindication | 230155003 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Dyspnea | contraindication | 267036007 | |
Anemia | contraindication | 271737000 | DOID:2355 |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Aplastic anemia | contraindication | 306058006 | DOID:12449 |
Osteopenia | contraindication | 312894000 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Granulocytopenic disorder | contraindication | 417672002 | |
Porphyria | contraindication | 418470004 | |
Fever greater than 100.4 Fahrenheit | contraindication | 426000000 | |
Hyperplasia of gingiva | contraindication | 441798003 | |
Congenital long QT syndrome | contraindication | 442917000 | |
HLA-B 1502 Positive Status | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 7.8 | acidic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium channel protein type 9 subunit alpha | Ion channel | BLOCKER | CHEMBL | CHEMBL | |||||
Sodium channel protein type 5 subunit alpha | Ion channel | BLOCKER | WOMBAT-PK | CHEMBL | |||||
Sodium channel protein type 1 subunit alpha | Ion channel | BLOCKER | CHEMBL | CHEMBL | |||||
Sodium channel protein type 2 subunit alpha | Ion channel | BLOCKER | IC50 | 4.90 | IUPHAR | CHEMBL | |||
Sodium channel protein type 3 subunit alpha | Ion channel | BLOCKER | CHEMBL | CHEMBL | |||||
Sodium channel protein type 4 subunit alpha | Ion channel | BLOCKER | Ki | 4.62 | CHEMBL | CHEMBL | |||
Sodium channel protein type 8 subunit alpha | Ion channel | BLOCKER | CHEMBL | CHEMBL | |||||
Nuclear receptor subfamily 1 group I member 3 | Nuclear hormone receptor | WOMBAT-PK | |||||||
Sodium channel alpha subunits; brain (Types I, II, III) | Ion channel | IC50 | 4.40 | CHEMBL | |||||
Sodium channel protein type 2 subunit alpha | Ion channel | IC50 | 4.66 | CHEMBL |
ID | Source |
---|---|
4017856 | VUID |
N0000146211 | NUI |
D00512 | KEGG_DRUG |
630-93-3 | SECONDARY_CAS_RN |
4017856 | VANDF |
4017857 | VANDF |
C0031507 | UMLSCUI |
CHEBI:8107 | CHEBI |
CHEMBL16 | ChEMBL_ID |
DB00252 | DRUGBANK_ID |
CHEMBL1611 | ChEMBL_ID |
D010672 | MESH_DESCRIPTOR_UI |
416 | INN_ID |
1775 | PUBCHEM_CID |
2624 | IUPHAR_LIGAND_ID |
6158TKW0C5 | UNII |
71227 | RXNORM |
1366 | MMSL |
5292 | MMSL |
5293 | MMSL |
72015 | MMSL |
d00143 | MMSL |
001617 | NDDF |
001619 | NDDF |
387220006 | SNOMEDCT_US |
387416005 | SNOMEDCT_US |
40556005 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Dilantin Infatabs | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-0007 | TABLET, CHEWABLE | 50 mg | ORAL | ANDA | 27 sections |
Dilantin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-0369 | CAPSULE | 100 mg | ORAL | ANDA | 28 sections |
Dilantin-125 | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-2214 | SUSPENSION | 125 mg | ORAL | NDA | 28 sections |
Dilantin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0071-3740 | CAPSULE | 30 mg | ORAL | ANDA | 28 sections |
Phenytoin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0892 | SUSPENSION | 125 mg | ORAL | ANDA | 27 sections |
Phenytoin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1560 | CAPSULE, EXTENDED RELEASE | 100 mg | ORAL | ANDA | 26 sections |
Phenytek | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-2670 | CAPSULE, EXTENDED RELEASE | 200 mg | ORAL | ANDA | 26 sections |
Phenytek | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3750 | CAPSULE, EXTENDED RELEASE | 300 mg | ORAL | ANDA | 26 sections |
Phenytoin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3850 | TABLET, CHEWABLE | 50 mg | ORAL | ANDA | 26 sections |
Phenytoin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9932 | INJECTION | 50 mg | INTRAMUSCULAR | ANDA | 16 sections |
Phenytoin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9933 | INJECTION | 250 mg | INTRAMUSCULAR | ANDA | 16 sections |
Phenytoin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8020 | CAPSULE, EXTENDED RELEASE | 100 mg | ORAL | ANDA | 26 sections |
Phenytoin Infatabs | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8260 | TABLET, CHEWABLE | 50 mg | ORAL | ANDA | 26 sections |
Phenytoin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-0493 | INJECTION | 50 mg | INTRAMUSCULAR | ANDA | 25 sections |
Phenytoin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-2555 | INJECTION | 50 mg | INTRAMUSCULAR | ANDA | 25 sections |
Phenytoin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6138 | INJECTION | 50 mg | INTRAMUSCULAR | ANDA | 25 sections |
Phenytoin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6139 | INJECTION | 50 mg | INTRAMUSCULAR | ANDA | 25 sections |
Extended Phenytoin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6187 | CAPSULE | 100 mg | ORAL | ANDA | 23 sections |
Phenytoin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-7079 | SUSPENSION | 100 mg | ORAL | ANDA | 27 sections |
Extended Phenytoin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10135-603 | CAPSULE, EXTENDED RELEASE | 100 mg | ORAL | ANDA | 23 sections |
PHENYTOINER | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-815 | CAPSULE | 100 mg | ORAL | ANDA | 3 sections |
Phenytoin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17856-0067 | SUSPENSION | 125 mg | ORAL | ANDA | 21 sections |
Phenytoin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17856-4070 | SUSPENSION | 125 mg | ORAL | ANDA | 28 sections |
Phenytoin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-167 | CAPSULE, EXTENDED RELEASE | 100 mg | ORAL | ANDA | 21 sections |
PHENYTOIN SODIUM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42192-614 | INJECTION | 50 mg | INTRAMUSCULAR | ANDA | 17 sections |
Extended Phenytoin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42291-772 | CAPSULE | 100 mg | ORAL | ANDA | 23 sections |
Extended Phenytoin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-492 | CAPSULE | 100 mg | ORAL | ANDA | 23 sections |
Dilantin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43353-131 | CAPSULE, EXTENDED RELEASE | 100 mg | ORAL | ANDA | 24 sections |
Dilantin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-0029 | CAPSULE, EXTENDED RELEASE | 100 mg | ORAL | ANDA | 26 sections |
Extended Phenytoin Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-2089 | CAPSULE | 100 mg | ORAL | ANDA | 23 sections |