androstenedione Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
steroids, androgens 215 63-05-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • androstenedione
  • fecundin
  • 4-Androstene-3,17-dione
A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.
  • Molecular weight: 286.42
  • Formula: C19H26O2
  • CLOGP: 3.01
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 34.14
  • ALOGS: -4.03
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:50113 androgens
CHEBI has role CHEBI:75771 Mus musculus metabolite
CHEBI has role CHEBI:77746 H. sapiens metabolites
CHEBI has role CHEBI:83056 Daphnia magna metabolites

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Aromatase Enzyme Ki 7.70 CHEMBL
Corticosteroid-binding globulin Secreted Ki 5.76 CHEMBL
Sex hormone-binding globulin Secreted Kd 7.46 CHEMBL
Testosterone 17-beta-dehydrogenase 3 Enzyme IC50 6.31 CHEMBL
Androgen receptor Transcription factor IC50 5.89 CHEMBL
Testosterone 17-beta-dehydrogenase 3 Enzyme IC50 6.77 CHEMBL

External reference:

IDSource
4021377 VUID
N0000148795 NUI
D00051 KEGG_DRUG
784 RXNORM
C0002860 UMLSCUI
CHEBI:16422 CHEBI
ASD PDB_CHEM_ID
CHEMBL274826 ChEMBL_ID
DB01536 DRUGBANK_ID
D000735 MESH_DESCRIPTOR_UI
6128 PUBCHEM_CID
2860 IUPHAR_LIGAND_ID
C042013 MESH_SUPPLEMENTAL_RECORD_UI
409J2J96VR UNII
011070 NDDF
56146000 SNOMEDCT_US
4021377 VANDF

Pharmaceutical products:

None