phenylephrine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
sympathomimetic, phenethyl derivatives 2146 59-42-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • (-)-Phenylephrine
  • (-)-m-Hydroxy-alpha-(methylaminomethyl)benzyl alcohol
  • (-)-m-Oxedrine
  • (-)-m-Synephrine
  • (R)-Phenylephrine
  • L-Phenylephedrine
  • mesatone
  • metaoxedrin
  • metaoxedrine
  • metasympatol
  • metasynephrine
  • mezaton
  • l-Phenylephrine
  • phenylephrine
  • phenylephrine hydrochloride
  • phenylephrine tannate
  • phenylephrine bitartrate
  • phenylephrine HCl
An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.
  • Molecular weight: 167.21
  • Formula: C9H13NO2
  • CLOGP: -0.09
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 3
  • TPSA: 52.49
  • ALOGS: -0.88
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
4 mg P
4 mg N
40 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 4.98 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 35 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Jan. 21, 1952 FDA ANI PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 1226.96 10.75 5843 721399 241407 62520373
Completed suicide 1147.69 10.75 3975 723267 141698 62620082
Exposure to toxic agent 686.52 10.75 545 726697 5042 62756738
Infusion related reaction 613.21 10.75 4859 722383 240662 62521118
Sinusitis 507.55 10.75 4377 722865 222276 62539504
Acute hepatic failure 460.51 10.75 785 726457 17542 62744238
Blood pressure fluctuation 415.05 10.75 1321 725921 44996 62716784
Muscle injury 283.99 10.75 1489 725753 63856 62697924
Irritable bowel syndrome 276.49 10.75 1753 725489 80659 62681121
Folliculitis 275.74 10.75 1558 725684 68759 62693021
Intentional overdose 266.15 10.75 1605 725637 72547 62689233
Overdose 244.55 10.75 2198 725044 112880 62648900
Lower respiratory tract infection 242.44 10.75 2449 724793 129858 62631922
Nasopharyngitis 240.98 10.75 4172 723070 250085 62511695
Intentional product misuse 239.01 10.75 1350 725892 59567 62702213
Device expulsion 230.10 10.75 58 727184 34864 62726916
Drug interaction 215.98 10.75 1636 725606 227495 62534285
Injection site pain 206.57 10.75 776 726466 129024 62632756
Drug ineffective 200.22 10.75 9862 717380 1034903 61726877
Ill-defined disorder 199.20 10.75 1610 725632 80145 62681635
Local anaesthetic systemic toxicity 192.38 10.75 123 727119 776 62761004
Metabolic acidosis 191.01 10.75 1020 726222 44049 62717731
Analgesic drug level increased 185.65 10.75 179 727063 2193 62759587
Blister 181.10 10.75 2278 724964 127536 62634244
Sleep disorder due to general medical condition, insomnia type 180.87 10.75 1120 726122 51097 62710683
Blood pressure increased 180.19 10.75 2731 724511 159331 62602449
Rheumatoid arthritis 179.27 10.75 3984 723258 249835 62511945
Anaemia 176.66 10.75 2334 724908 291096 62470684
Anion gap 173.76 10.75 134 727108 1183 62760597
Hepatic cytolysis 172.83 10.75 476 726766 14931 62746849
Blood pressure diastolic abnormal 163.85 10.75 450 726792 14092 62747688
Body temperature increased 151.70 10.75 833 726409 36359 62725421
Hepatotoxicity 151.34 10.75 830 726412 36211 62725569
Cardiac failure 151.04 10.75 519 726723 88623 62673157
Duodenal ulcer perforation 148.67 10.75 1591 725651 85618 62676162
Helicobacter infection 148.20 10.75 1671 725571 91114 62670666
Neutropenia 148.10 10.75 1286 725956 173719 62588061
Heart rate decreased 145.31 10.75 957 726285 44603 62717177
Blood pressure systolic increased 142.43 10.75 981 726261 46416 62715364
Blood pressure systolic abnormal 141.75 10.75 405 726837 12981 62748799
Injection site erythema 141.09 10.75 484 726758 82690 62679090
Impaired healing 140.25 10.75 1793 725449 100749 62661031
Drug resistance 140.10 10.75 44 727198 22889 62738891
Throat irritation 137.67 10.75 819 726423 36828 62724952
Oxygen saturation decreased 137.26 10.75 1586 725656 86999 62674781
Heart rate increased 134.08 10.75 1660 725582 92578 62669202
Sopor 132.79 10.75 44 727198 22120 62739660
Weight increased 130.61 10.75 3911 723331 256881 62504899
Pancytopenia 128.64 10.75 621 726621 96312 62665468
Malignant neoplasm progression 126.72 10.75 497 726745 81624 62680156
Wrong technique in product usage process 124.87 10.75 336 726906 62004 62699776
Intentional product use issue 123.65 10.75 2106 725136 125786 62635994
Gastrointestinal disorder 117.19 10.75 2134 725108 129105 62632675
Hyponatraemia 115.51 10.75 778 726464 111122 62650658
Osteonecrosis of jaw 112.49 10.75 142 727100 34981 62726799
Ear pain 112.36 10.75 754 726488 35364 62726416
Bone marrow failure 112.10 10.75 102 727140 29188 62732592
Infusion site pain 111.26 10.75 435 726807 16434 62745346
Peripheral swelling 110.55 10.75 3901 723341 262041 62499739
Hepatic enzyme increased 108.86 10.75 3062 724180 199266 62562514
Injection site reaction 107.99 10.75 328 726914 58196 62703584
Blood pressure diastolic decreased 104.59 10.75 526 726716 22180 62739600
Medication error 103.10 10.75 983 726259 51301 62710479
Joint swelling 99.39 10.75 4647 722595 323019 62438761
Acute kidney injury 98.29 10.75 2282 724960 261133 62500647
Anti-cyclic citrullinated peptide antibody positive 97.97 10.75 1873 725369 114339 62647441
Thrombocytopenia 97.28 10.75 1185 726057 149972 62611808
Pericarditis 95.50 10.75 2074 725168 129505 62632275
Infusion site swelling 92.41 10.75 284 726958 9486 62752294
Infusion site extravasation 92.12 10.75 296 726946 10130 62751650
Psoriasis 91.03 10.75 602 726640 86355 62675425
Muscle spasticity 90.80 10.75 491 726751 21303 62740477
Leukopenia 89.78 10.75 518 726724 76772 62685008
Coagulopathy 88.43 10.75 467 726775 20077 62741703
Abortion spontaneous 88.16 10.75 263 726979 46932 62714848
Disease progression 87.73 10.75 940 726302 121818 62639962
Stomatitis 86.87 10.75 2142 725100 136583 62625197
COVID-19 86.34 10.75 1796 725446 111307 62650473
Myelosuppression 85.52 10.75 87 727155 23616 62738164
Product dose omission issue 85.14 10.75 2038 725204 232275 62529505
Pruritus 84.73 10.75 5003 722239 356450 62405330
Blood parathyroid hormone decreased 80.46 10.75 9 727233 9782 62751998
Injection site pruritus 80.30 10.75 257 726985 44859 62716921
Infusion site erythema 80.16 10.75 305 726937 11374 62750406
Hyperkalaemia 79.86 10.75 334 726908 53869 62707911
Urine leukocyte esterase positive 79.18 10.75 145 727097 3434 62758346
Interstitial lung disease 79.03 10.75 402 726840 61506 62700274
Cardiac failure congestive 78.23 10.75 679 726563 91754 62670026
Hypersensitivity 77.51 10.75 4097 723145 288588 62473192
Depressed level of consciousness 77.18 10.75 1067 726175 61011 62700769
Toxic anterior segment syndrome 76.64 10.75 98 727144 1673 62760107
Injection site bruising 76.52 10.75 236 727006 41674 62720106
Diarrhoea 76.37 10.75 7107 720135 708259 62053521
Septic shock 76.08 10.75 449 726793 66180 62695600
Hypokalaemia 75.73 10.75 791 726451 103013 62658767
Urine abnormality 73.96 10.75 212 727030 6807 62754973
Sedation complication 73.67 10.75 334 726908 13488 62748292
Drug hypersensitivity 71.76 10.75 2870 724372 307817 62453963
Infusion site pruritus 70.23 10.75 189 727053 5846 62755934
Hypocalcaemia 68.07 10.75 165 727077 31548 62730232
Suicide attempt 67.78 10.75 1027 726215 59891 62701889
Red blood cell sedimentation rate abnormal 67.59 10.75 76 727166 19706 62742074
Renal impairment 66.21 10.75 669 726573 87686 62674094
Blood pressure diastolic increased 65.91 10.75 258 726984 9752 62752028
Mucosal inflammation 65.57 10.75 295 726947 46633 62715147
Haematotoxicity 64.88 10.75 14 727228 9362 62752418
Injection site swelling 64.72 10.75 302 726940 47270 62714510
Ear pruritus 63.03 10.75 140 727102 3825 62757955
Respiratory depression 62.66 10.75 317 726925 13398 62748382
Granuloma skin 61.74 10.75 11 727231 8426 62753354
Pyroglutamic acidosis 61.53 10.75 54 727188 581 62761199
Panniculitis 60.90 10.75 27 727215 11358 62750422
Cytomegalovirus infection 60.76 10.75 91 727151 20861 62740919
Creatinine renal clearance decreased 60.40 10.75 356 726886 15952 62745828
Maternal exposure during delivery 60.24 10.75 80 727162 1420 62760360
Urticaria 60.12 10.75 2396 724846 163406 62598374
Hospitalisation 58.97 10.75 656 726586 84425 62677355
Lactic acidosis 58.86 10.75 232 727010 38055 62723725
Acute lung injury 58.85 10.75 81 727161 1490 62760290
Headache 58.74 10.75 8191 719051 625050 62136730
Therapeutic product effect decreased 58.72 10.75 2741 724501 190446 62571334
Epilepsy 57.95 10.75 141 727101 26924 62734856
Blood calcium decreased 57.55 10.75 508 726734 25943 62735837
Therapeutic response decreased 57.53 10.75 440 726802 61085 62700695
Myocardial infarction 56.94 10.75 803 726439 99090 62662690
Poor venous access 56.87 10.75 326 726916 14459 62747321
Posterior reversible encephalopathy syndrome 56.72 10.75 69 727173 17276 62744504
Poisoning deliberate 56.05 10.75 266 726976 10952 62750828
Product prescribing error 53.92 10.75 140 727102 26149 62735631
Product substitution issue 51.92 10.75 64 727178 15932 62745848
Skin necrosis 51.71 10.75 50 727192 13900 62747880
Therapy cessation 51.11 10.75 178 727064 30279 62731501
Foetal exposure during pregnancy 50.86 10.75 191 727051 31771 62730009
Palmar-plantar erythrodysaesthesia syndrome 50.79 10.75 118 727124 22897 62738883
White blood cells urine positive 50.72 10.75 152 727090 5006 62756774
Weight fluctuation 50.65 10.75 235 727007 9584 62752196
Night sweats 50.14 10.75 812 726430 48002 62713778
Urinary sediment present 49.68 10.75 90 727152 2113 62759667
Renal failure 49.67 10.75 999 726243 116653 62645127
Infection 49.67 10.75 3151 724091 226022 62535758
Device dislocation 49.64 10.75 141 727101 25564 62736216
Pneumocystis jirovecii pneumonia 49.50 10.75 73 727169 16841 62744939
Heart rate irregular 48.98 10.75 431 726811 21990 62739790
Bronchial secretion retention 48.77 10.75 102 727140 2671 62759109
Arthralgia 48.67 10.75 7335 719907 562375 62199405
Drug eruption 47.95 10.75 168 727074 28526 62733254
Pyroglutamate increased 47.82 10.75 40 727202 401 62761379
Device malfunction 47.60 10.75 82 727160 17775 62744005
Hypercalcaemia 47.21 10.75 166 727076 28156 62733624
Agranulocytosis 46.98 10.75 140 727102 24994 62736786
Device adhesion issue 46.96 10.75 3 727239 5138 62756642
Transplant rejection 46.94 10.75 33 727209 10747 62751033
Neoplasm progression 46.80 10.75 236 727006 36192 62725588
Breast cancer stage I 46.24 10.75 11 727231 6878 62754902
Contusion 45.60 10.75 2129 725113 147915 62613865
Rheumatoid nodule 45.53 10.75 79 727163 17076 62744704
Myelodysplastic syndrome 45.52 10.75 76 727166 16678 62745102
Diabetic ketoacidosis 45.35 10.75 105 727137 20400 62741380
Therapeutic product effect incomplete 45.01 10.75 1089 726153 123967 62637813
Diabetes mellitus 45.01 10.75 415 726827 55395 62706385
Respiratory arrest 44.67 10.75 571 726671 32074 62729706
Thrombotic microangiopathy 43.83 10.75 34 727208 10527 62751253
Red blood cells urine positive 43.77 10.75 105 727137 3021 62758759
Infusion site haemorrhage 43.67 10.75 143 727099 4943 62756837
Hepatic necrosis 43.65 10.75 154 727088 5533 62756247
Product storage error 43.33 10.75 65 727177 14891 62746889
Breast cancer female 43.22 10.75 55 727187 13504 62748276
Incorrect drug administration rate 43.05 10.75 121 727121 3841 62757939
Surgery 42.60 10.75 239 727003 35673 62726107
Respiratory disorder 42.36 10.75 656 726586 38426 62723354
Decreased appetite 42.24 10.75 2398 724844 248654 62513126
Kounis syndrome 42.01 10.75 73 727169 1657 62760123
Back pain 41.93 10.75 3542 723700 260603 62501177
Anion gap abnormal 41.57 10.75 36 727206 380 62761400
Osteonecrosis 41.41 10.75 143 727099 24387 62737393
Inappropriate schedule of product administration 40.89 10.75 1516 725726 102449 62659331
Lymphocyte count decreased 40.88 10.75 528 726714 29729 62732051
Post transplant lymphoproliferative disorder 40.41 10.75 5 727237 5026 62756754
Temperature regulation disorder 40.33 10.75 158 727084 5974 62755806
Swelling 40.05 10.75 3669 723573 271709 62490071
Pathogen resistance 39.58 10.75 12 727230 6386 62755394
Electric shock 39.21 10.75 61 727181 1259 62760521
Crystal urine present 39.13 10.75 69 727173 1585 62760195
Infusion site bruising 38.70 10.75 114 727128 3718 62758062
Unintentional medical device removal 38.68 10.75 11 727231 6104 62755676
Seizure 38.66 10.75 1190 726052 131444 62630336
Injection site warmth 38.51 10.75 72 727170 15123 62746657
Genital haemorrhage 38.26 10.75 18 727224 7314 62754466
Suicidal ideation 38.01 10.75 495 726747 61926 62699854
Hyperglycaemia 37.93 10.75 302 726940 41565 62720215
Alopecia 37.91 10.75 3339 723903 334197 62427583
Basal cell carcinoma 37.89 10.75 178 727064 27813 62733967
Hepatic failure 37.70 10.75 596 726646 35060 62726720
Discomfort 37.66 10.75 2309 724933 165065 62596715
Oedema peripheral 37.60 10.75 1780 725462 187731 62574049
Accidental exposure to product 37.26 10.75 174 727068 27231 62734549
Polyneuropathy 37.08 10.75 69 727173 14520 62747260
Platelet count decreased 37.06 10.75 1029 726213 115093 62646687
Injection site haemorrhage 36.95 10.75 148 727094 24166 62737614
Therapy interrupted 36.89 10.75 219 727023 32236 62729544
Respiratory rate increased 36.66 10.75 275 726967 13373 62748407
Systemic infection 36.54 10.75 5 727237 4655 62757125
Metastases to bone 36.52 10.75 121 727121 20898 62740882
Bursitis 36.50 10.75 612 726630 36429 62725351
Metastases to liver 36.49 10.75 143 727099 23496 62738284
Drug withdrawal syndrome 36.18 10.75 174 727068 27020 62734760
Accidental overdose 35.93 10.75 417 726825 22892 62738888
Gastrointestinal haemorrhage 35.86 10.75 684 726558 80492 62681288
Illness 35.46 10.75 773 726469 48286 62713494
Metastases to lung 35.42 10.75 57 727185 12693 62749087
Flushing 35.08 10.75 1117 726125 73970 62687810
Device difficult to use 34.81 10.75 58 727184 12738 62749042
Cerebral infarction 34.71 10.75 148 727094 23745 62738035
Blood urine present 34.66 10.75 293 726949 14776 62747004
No adverse event 34.21 10.75 306 726936 41099 62720681
General physical health deterioration 34.18 10.75 1922 725320 199480 62562300
Synovitis 33.97 10.75 2533 724709 184385 62577395
Febrile bone marrow aplasia 33.82 10.75 21 727221 7304 62754476
Confusional state 33.69 10.75 3145 724097 233235 62528545
Ascites 33.65 10.75 301 726941 40427 62721353
Urine analysis abnormal 33.61 10.75 130 727112 4886 62756894
Body temperature fluctuation 33.35 10.75 78 727164 2207 62759573
Multiple organ dysfunction syndrome 33.12 10.75 454 726788 56298 62705482
Food allergy 33.08 10.75 234 727008 11167 62750613
Oropharyngeal pain 32.97 10.75 1360 725882 93127 62668653
Inappropriate antidiuretic hormone secretion 32.75 10.75 81 727161 15381 62746399
Intentional self-injury 32.66 10.75 167 727075 25520 62736260
Femur fracture 32.60 10.75 313 726929 41443 62720337
Red cell distribution width increased 32.30 10.75 219 727023 10305 62751475
Transplant dysfunction 32.27 10.75 8 727234 4864 62756916
Therapeutic response shortened 32.19 10.75 240 727002 11648 62750132
Psoriatic arthropathy 32.10 10.75 800 726442 90720 62671060
Fracture 31.83 10.75 116 727126 19468 62742312
Chest discomfort 31.63 10.75 1552 725690 108417 62653363
Rhabdomyolysis 31.60 10.75 336 726906 43615 62718165
Hypomagnesaemia 31.57 10.75 196 727046 28541 62733239
Neuroleptic malignant syndrome 31.56 10.75 56 727186 12000 62749780
Akathisia 31.40 10.75 35 727207 9111 62752669
Syncope 31.38 10.75 1065 726177 116320 62645460
Cognitive disorder 31.17 10.75 849 726393 54966 62706814
Cerebrovascular accident 31.03 10.75 971 726271 107053 62654727
Haemophagocytic lymphohistiocytosis 30.97 10.75 46 727196 10581 62751199
Cardio-respiratory arrest 30.96 10.75 903 726339 59056 62702724
Lymphocyte percentage decreased 30.34 10.75 89 727153 2896 62758884
Device use error 30.29 10.75 14 727228 5747 62756033
Injection site rash 30.18 10.75 112 727130 18697 62743083
Suspected suicide 30.14 10.75 152 727090 6416 62755364
Respiratory failure 30.13 10.75 912 726330 100946 62660834
Second primary malignancy 30.07 10.75 28 727214 7925 62753855
Hepatocellular injury 29.95 10.75 187 727055 27194 62734586
Chills 29.92 10.75 1587 725655 111791 62649989
Vital capacity decreased 29.74 10.75 63 727179 1665 62760115
Multiple-drug resistance 29.71 10.75 11 727231 5159 62756621
Sputum culture positive 29.50 10.75 72 727170 2095 62759685
Body temperature decreased 29.34 10.75 359 726883 19960 62741820
Underdose 29.26 10.75 189 727053 27267 62734513
Rheumatic fever 29.19 10.75 673 726569 42438 62719342
Hypotension 29.17 10.75 3558 723684 269046 62492734
Galactorrhoea 29.17 10.75 6 727236 4149 62757631
Anterior spinal artery syndrome 29.00 10.75 18 727224 107 62761673
Gestational diabetes 28.96 10.75 32 727210 8364 62753416
Multiple allergies 28.96 10.75 263 726979 13539 62748241
Device issue 28.90 10.75 157 727085 23624 62738156
Exposure via ingestion 28.86 10.75 86 727156 2823 62758957
Tardive dyskinesia 28.68 10.75 33 727209 8469 62753311
Labelled drug-drug interaction medication error 28.53 10.75 70 727172 13329 62748451
Blood iron abnormal 28.48 10.75 5 727237 3871 62757909
Neuropathy peripheral 28.38 10.75 1040 726202 112627 62649153
Injection site induration 27.81 10.75 39 727203 9187 62752593
Schizoaffective disorder 27.81 10.75 97 727145 3465 62758315
Hypothyroidism 27.48 10.75 334 726908 42298 62719482
Pyrexia 27.35 10.75 5939 721303 464539 62297241
Sexual dysfunction 27.28 10.75 8 727234 4351 62757429
Anaphylactic reaction 27.24 10.75 969 726273 65131 62696649
Skin toxicity 27.14 10.75 10 727232 4704 62757076
Blood pH decreased 27.12 10.75 78 727164 2509 62759271
Acute myeloid leukaemia 26.93 10.75 103 727139 17044 62744736
Culture urine positive 26.73 10.75 98 727144 3589 62758191
Bronchopulmonary aspergillosis 26.53 10.75 36 727206 8599 62753181
Hallucination, auditory 26.52 10.75 68 727174 12756 62749024
Hepatic cirrhosis 26.50 10.75 170 727072 24564 62737216
Administration site swelling 26.48 10.75 51 727191 1256 62760524
Colorectal cancer 26.14 10.75 5 727237 3640 62758140
Administration site pain 26.12 10.75 40 727202 814 62760966
Rheumatoid lung 26.11 10.75 6 727236 3842 62757938
Injury 25.94 10.75 1056 726186 72191 62689589
Pneumonia aspiration 25.67 10.75 262 726980 34278 62727502
Drug use disorder 25.50 10.75 119 727123 4865 62756915
Disorientation 25.46 10.75 309 726933 39143 62722637
Torsade de pointes 25.22 10.75 74 727168 13277 62748503
Paraesthesia 24.99 10.75 1507 725735 155459 62606321
Skin ulcer 24.88 10.75 345 726897 42700 62719080
Infusion site rash 24.78 10.75 64 727178 1930 62759850
Neutrophil percentage increased 24.60 10.75 82 727160 2861 62758919
Injection site urticaria 24.46 10.75 81 727161 13992 62747788
Infusion site mass 24.30 10.75 65 727177 2003 62759777
Cardiotoxicity 24.13 10.75 37 727205 8401 62753379
Dyskinesia 24.09 10.75 242 727000 31760 62730020
Bacterial test 24.02 10.75 46 727196 1128 62760652
Poisoning 23.82 10.75 251 726991 13449 62748331
Upper respiratory tract infection 23.81 10.75 1159 726083 80888 62680892
Product monitoring error 23.70 10.75 11 727231 4505 62757275
Seasonal allergy 23.61 10.75 354 726888 20596 62741184
Hepatic function abnormal 23.55 10.75 292 726950 36850 62724930
Condition aggravated 23.41 10.75 4152 723090 398065 62363715
Brain death 23.36 10.75 89 727153 3321 62758459
Cerebral haemorrhage 23.29 10.75 232 727010 30497 62731283
Dehydration 23.26 10.75 1690 725552 171664 62590116
Hypertensive crisis 23.26 10.75 93 727149 15193 62746587
Drug dose omission by device 23.25 10.75 13 727229 4788 62756992
Anticipatory anxiety 23.16 10.75 47 727195 1204 62760576
Hypocoagulable state 23.12 10.75 46 727196 1161 62760619
Rash pruritic 23.11 10.75 515 726727 59284 62702496
Specific gravity urine decreased 23.04 10.75 36 727206 746 62761034
Haemoglobin urine present 23.02 10.75 37 727205 786 62760994
Ear infection 22.99 10.75 587 726655 37626 62724154
Anion gap increased 22.98 10.75 60 727182 1822 62759958
Urine ketone body present 22.97 10.75 72 727170 2431 62759349
Infusion site nodule 22.95 10.75 52 727190 1440 62760340
Swollen joint count increased 22.93 10.75 558 726684 35496 62726284
Reversible airways obstruction 22.77 10.75 59 727183 1783 62759997
Aspergillus infection 22.65 10.75 36 727206 8057 62753723
Electrocardiogram QT prolonged 22.35 10.75 515 726727 59015 62702765
Metastases to lymph nodes 22.17 10.75 37 727205 8121 62753659
Fatigue 22.10 10.75 10845 716397 877183 61884597
Graft versus host disease 22.01 10.75 27 727215 6736 62755044
Intervertebral discitis 21.90 10.75 84 727158 3144 62758636
Dizziness 21.71 10.75 4471 722771 425454 62336326
Peritonitis 21.54 10.75 112 727130 17042 62744738
Vein collapse 21.48 10.75 41 727201 1003 62760777
Epstein-Barr virus infection 21.43 10.75 37 727205 8013 62753767
Blood magnesium increased 21.40 10.75 80 727162 2958 62758822
Acute myocardial infarction 21.34 10.75 250 726992 31874 62729906
Human herpesvirus 6 infection 21.33 10.75 4 727238 2953 62758827
Musculoskeletal disorder 21.05 10.75 144 727098 20500 62741280
Prothrombin time prolonged 20.97 10.75 184 727058 9380 62752400
Peptic ulcer haemorrhage 20.82 10.75 41 727201 1027 62760753
Varicella zoster virus infection 20.82 10.75 3 727239 2686 62759094
Graft versus host disease in skin 20.80 10.75 4 727238 2901 62758879
Rhythm idioventricular 20.68 10.75 20 727222 246 62761534
Analgesic drug level above therapeutic 20.68 10.75 17 727225 166 62761614
Right ventricular failure 20.60 10.75 114 727128 17074 62744706
Personality change 20.50 10.75 30 727212 6943 62754837
Anaesthetic complication 20.46 10.75 59 727183 1901 62759879
Femoral neck fracture 20.20 10.75 42 727200 8481 62753299
Coeliac disease 20.20 10.75 230 727012 12567 62749213
Hand deformity 20.14 10.75 2104 725138 157353 62604427
Methaemoglobinaemia 20.13 10.75 67 727175 2336 62759444
Haematuria 20.12 10.75 225 727017 28932 62732848
Cytomegalovirus viraemia 20.08 10.75 21 727221 5628 62756152
Dysarthria 20.07 10.75 356 726886 42355 62719425
Wound 20.03 10.75 2150 725092 161113 62600667
Acute graft versus host disease 20.02 10.75 13 727229 4415 62757365
Jaundice cholestatic 19.91 10.75 148 727094 7176 62754604
Dystonia 19.83 10.75 86 727156 13733 62748047
Sensitisation 19.80 10.75 7 727235 3379 62758401
SARS-CoV-2 test positive 19.79 10.75 159 727083 7897 62753883
Insurance issue 19.77 10.75 129 727113 5992 62755788
Breast cancer 19.76 10.75 413 726829 47970 62713810
Anosognosia 19.76 10.75 6 727236 3190 62758590
Infusion site discomfort 19.64 10.75 48 727194 1398 62760382
Drug reaction with eosinophilia and systemic symptoms 19.62 10.75 271 726971 33565 62728215
Mania 19.61 10.75 74 727168 12293 62749487
Infusion site urticaria 19.61 10.75 51 727191 1545 62760235
Injection site haematoma 19.50 10.75 30 727212 6802 62754978
Product tampering 19.48 10.75 24 727218 394 62761386
Cardiac failure acute 19.31 10.75 51 727191 9472 62752308
Ovarian hyperstimulation syndrome 19.25 10.75 11 727231 4003 62757777
Enthesopathy 19.14 10.75 44 727198 8570 62753210
Chronic graft versus host disease 18.86 10.75 6 727236 3096 62758684
Pneumocephalus 18.85 10.75 16 727226 164 62761616
Fall 18.75 10.75 4091 723151 388243 62373537
Depression 18.74 10.75 1967 725275 194525 62567255
Abnormal dreams 18.64 10.75 60 727182 10456 62751324
Neurotoxicity 18.60 10.75 116 727126 16874 62744906
Cytokine release syndrome 18.59 10.75 248 726994 14066 62747714
Pleural fibrosis 18.58 10.75 84 727158 3388 62758392
Infusion site irritation 18.49 10.75 36 727206 894 62760886
Systemic toxicity 18.49 10.75 12 727230 78 62761702
Mucormycosis 18.47 10.75 5 727237 2866 62758914
Abortion induced 18.46 10.75 58 727184 10184 62751596
Brain oedema 18.46 10.75 246 726996 13949 62747831
Peripheral sensory neuropathy 18.27 10.75 36 727206 7415 62754365
Presbyacusis 18.18 10.75 73 727169 2792 62758988
Lymphopenia 18.12 10.75 129 727113 18198 62743582
Loss of consciousness 18.10 10.75 1138 726104 116983 62644797
Bone pain 17.99 10.75 482 726760 54159 62707621
Atypical femur fracture 17.96 10.75 21 727221 5351 62756429
Brain stem glioma 17.95 10.75 16 727226 176 62761604
Ischaemic stroke 17.94 10.75 126 727116 17831 62743949
Lupus vasculitis 17.89 10.75 27 727215 542 62761238
Multiple drug therapy 17.89 10.75 86 727156 3560 62758220
Coronary artery disease 17.83 10.75 262 726980 32115 62729665
Hypomania 17.83 10.75 129 727113 6201 62755579
Mobility decreased 17.69 10.75 1615 725627 119544 62642236
Atelectasis 17.66 10.75 345 726897 21138 62740642
Corneal oedema 17.62 10.75 47 727195 1446 62760334
Administration site bruise 17.54 10.75 23 727219 403 62761377
Scoliosis 17.42 10.75 152 727090 7736 62754044
White blood cell count decreased 17.40 10.75 1364 725878 137740 62624040
Immunosuppressant drug level increased 17.40 10.75 10 727232 3628 62758152
Coagulation factor VII level decreased 17.34 10.75 12 727230 88 62761692
Concussion 17.33 10.75 172 727070 9072 62752708
Sinus operation 17.31 10.75 67 727175 2519 62759261
Treatment noncompliance 17.26 10.75 312 726930 37013 62724767
Bacterial test positive 17.23 10.75 112 727130 5195 62756585
Nausea 17.19 10.75 9217 718025 845254 61916526
Electrolyte imbalance 17.19 10.75 147 727095 19929 62741851
Pleural thickening 17.15 10.75 72 727170 2811 62758969
Eosinophil percentage increased 17.11 10.75 37 727205 992 62760788
Prothrombin time shortened 17.05 10.75 56 727186 1939 62759841
Small for dates baby 16.98 10.75 11 727231 3740 62758040
Migraine 16.87 10.75 1389 725853 101957 62659823
Congestive cardiomyopathy 16.83 10.75 28 727214 6154 62755626
Vaginal haemorrhage 16.72 10.75 218 727024 27269 62734511
Drug tolerance 16.68 10.75 34 727208 6915 62754865
Cardiovascular disorder 16.65 10.75 74 727168 11738 62750042
Oesophageal carcinoma 16.61 10.75 4 727238 2480 62759300
Coma 16.59 10.75 899 726343 63465 62698315
Lupus-like syndrome 16.45 10.75 105 727137 15190 62746590
Nerve block 16.44 10.75 31 727211 751 62761029
Coagulation factor X level decreased 16.41 10.75 11 727231 76 62761704
Transient ischaemic attack 16.39 10.75 319 726923 37434 62724346
Orthostatic hypotension 16.38 10.75 536 726706 35624 62726156
Erysipelas 16.29 10.75 42 727200 7863 62753917
Superinfection 16.21 10.75 66 727176 2541 62759239
Blood creatinine decreased 16.20 10.75 114 727128 5431 62756349
Pain 16.20 10.75 9010 718232 731618 62030162
Disturbance in attention 16.19 10.75 324 726918 37865 62723915
Cytopenia 16.16 10.75 73 727169 11528 62750252
Abnormal behaviour 16.14 10.75 162 727080 21264 62740516
Pancreatic carcinoma 16.12 10.75 40 727202 7588 62754192
Hypersensitivity vasculitis 16.12 10.75 14 727228 4098 62757682
Therapy non-responder 16.03 10.75 708 726534 75193 62686587
Injection site discolouration 15.94 10.75 42 727200 7806 62753974
Ketoacidosis 15.87 10.75 16 727226 4362 62757418
Bacterial disease carrier 15.81 10.75 42 727200 1289 62760491
Acute graft versus host disease in skin 15.79 10.75 10 727232 3442 62758338
Cardiac arrest 15.78 10.75 1248 725994 91297 62670483
Osmolar gap 15.74 10.75 12 727230 104 62761676
Epigastric discomfort 15.68 10.75 132 727110 6648 62755132
Hyperprolactinaemia 15.63 10.75 13 727229 3887 62757893
Nephropathy toxic 15.50 10.75 56 727186 9423 62752357
Maternal exposure during pregnancy 15.48 10.75 2247 724995 217815 62543965
Ventilation perfusion mismatch 15.47 10.75 24 727218 494 62761286
Pulmonary hypertension 15.42 10.75 316 726926 36807 62724973
Soft tissue disorder 15.40 10.75 95 727147 4327 62757453
Sepsis 15.40 10.75 1527 725715 151596 62610184
Anaesthetic complication neurological 15.38 10.75 17 727225 247 62761533
Blood immunoglobulin E increased 15.21 10.75 13 727229 3836 62757944
Aphasia 15.21 10.75 276 726966 32724 62729056
Atrial fibrillation 15.17 10.75 1140 726102 115496 62646284
Metastases to central nervous system 15.12 10.75 88 727154 13017 62748763
Haematemesis 15.09 10.75 251 726991 30161 62731619
Pharyngeal paraesthesia 15.07 10.75 54 727188 1955 62759825
Nephrogenic systemic fibrosis 15.03 10.75 18 727224 4538 62757242
Leukoencephalopathy 15.02 10.75 17 727225 4396 62757384
Epistaxis 15.02 10.75 680 726562 72045 62689735
Pregnancy with contraceptive device 15.00 10.75 19 727223 4675 62757105
Blood glucose increased 14.98 10.75 795 726447 82961 62678819
Lymphoproliferative disorder 14.93 10.75 9 727233 3181 62758599
Hyperammonaemia 14.91 10.75 23 727219 5209 62756571
Hypoglycaemia 14.89 10.75 550 726692 59515 62702265
Pulmonary arterial hypertension 14.88 10.75 176 727066 22401 62739379
Granuloma 14.86 10.75 27 727215 5734 62756046
Visual acuity reduced 14.83 10.75 169 727073 21657 62740123
Malaise 14.73 10.75 4396 722846 411558 62350222
Proteinuria 14.73 10.75 144 727098 19001 62742779
Irritability 14.63 10.75 265 726977 31429 62730351
Immunodeficiency 14.59 10.75 319 726923 19935 62741845
Occupational exposure to product 14.59 10.75 3 727239 2075 62759705
Aplasia pure red cell 14.51 10.75 18 727224 4469 62757311
Injection site mass 14.49 10.75 140 727102 18516 62743264
Polycystic ovaries 14.39 10.75 18 727224 4453 62757327
JC virus infection 14.32 10.75 3 727239 2048 62759732
Specific gravity urine increased 14.28 10.75 15 727227 205 62761575
COVID-19 immunisation 14.24 10.75 49 727193 1738 62760042
C-reactive protein increased 14.24 10.75 914 726328 93793 62667987
Haemorrhage 14.19 10.75 563 726679 60459 62701321
Unintended pregnancy 14.19 10.75 31 727211 6148 62755632
Bone erosion 14.17 10.75 132 727110 17585 62744195
Foetal growth restriction 14.17 10.75 42 727200 7511 62754269
Cryopyrin associated periodic syndrome 14.15 10.75 19 727223 341 62761439
Blood cholesterol increased 14.12 10.75 1256 725986 92776 62669004
Dermatitis bullous 14.09 10.75 50 727192 8458 62753322
Neuralgia 14.09 10.75 393 726849 25533 62736247
Tendonitis 14.08 10.75 150 727092 19465 62742315
Fear of injection 14.05 10.75 39 727203 7125 62754655
Graft versus host disease in gastrointestinal tract 14.01 10.75 10 727232 3231 62758549
Clostridium test positive 13.94 10.75 73 727169 3128 62758652
PO2 increased 13.93 10.75 31 727211 848 62760932
Eyelid rash 13.89 10.75 13 727229 153 62761627
Pancreatitis acute 13.88 10.75 223 727019 26943 62734837
Joint destruction 13.84 10.75 32 727210 6220 62755560
Metabolic disorder 13.82 10.75 34 727208 6469 62755311
Patent ductus arteriosus 13.80 10.75 17 727225 4233 62757547
Complication associated with device 13.79 10.75 126 727116 16852 62744928
Cytomegalovirus infection reactivation 13.79 10.75 15 727227 3948 62757832
Hepatocellular carcinoma 13.78 10.75 4 727238 2190 62759590
Foot operation 13.71 10.75 40 727202 7191 62754589
Pulmonary tuberculosis 13.71 10.75 19 727223 4498 62757282
Melaena 13.67 10.75 255 726987 30110 62731670
Stoma site cellulitis 13.67 10.75 8 727234 42 62761738
Ductus arteriosus premature closure 13.62 10.75 18 727224 318 62761462
Renal disorder 13.60 10.75 281 726961 32693 62729087
Immune reconstitution inflammatory syndrome 13.58 10.75 31 727211 6053 62755727
Caesarean section 13.58 10.75 127 727115 16905 62744875
Diffuse large B-cell lymphoma 13.57 10.75 36 727206 6676 62755104
Catatonia 13.42 10.75 19 727223 4458 62757322
Extrapyramidal disorder 13.38 10.75 93 727149 13191 62748589
Gastroenteritis 13.35 10.75 219 727023 26371 62735409
Throat tightness 13.17 10.75 376 726866 24511 62737269
Spinal meningioma benign 13.17 10.75 11 727231 110 62761670
Blood methaemoglobin present 13.11 10.75 9 727233 65 62761715
Hepatitis acute 13.11 10.75 161 727081 8959 62752821
Disease recurrence 13.05 10.75 234 727008 27796 62733984
Hallucinations, mixed 13.03 10.75 22 727220 4807 62756973
Myopathy 12.99 10.75 75 727167 11116 62750664
Product quality issue 12.98 10.75 312 726930 35553 62726227
Blood immunoglobulin A increased 12.97 10.75 28 727214 750 62761030
Non-pitting oedema 12.96 10.75 8 727234 47 62761733
Kidney transplant rejection 12.93 10.75 18 727224 4253 62757527
Polyarthritis 12.88 10.75 66 727176 10080 62751700
Hepatic encephalopathy 12.85 10.75 191 727051 11091 62750689
Product residue present 12.83 10.75 16 727226 3963 62757817
Coagulation factor decreased 12.81 10.75 10 727232 90 62761690
Nephrotic syndrome 12.78 10.75 28 727214 5548 62756232
Breast cancer stage II 12.76 10.75 54 727188 8682 62753098
Sedation 12.72 10.75 555 726687 38254 62723526
Post cholecystectomy syndrome 12.64 10.75 20 727222 419 62761361
Hepatitis B 12.64 10.75 15 727227 3797 62757983
Cestode infection 12.61 10.75 16 727226 271 62761509
Procedural hypotension 12.59 10.75 36 727206 1154 62760626
Chronic kidney disease 12.57 10.75 410 726832 44988 62716792
White coat hypertension 12.55 10.75 26 727216 676 62761104
Potentiating drug interaction 12.55 10.75 19 727223 4337 62757443
Device breakage 12.53 10.75 79 727163 11463 62750317
Abnormal loss of weight 12.47 10.75 30 727212 5752 62756028
Neovascularisation 12.47 10.75 35 727207 1110 62760670
Renal failure neonatal 12.47 10.75 13 727229 176 62761604
Dyspnoea exertional 12.42 10.75 564 726678 59738 62702042
Lip pruritus 12.40 10.75 31 727211 916 62760864
Skin infection 12.36 10.75 241 727001 14761 62747019
Schizophrenia 12.34 10.75 171 727071 9781 62751999
Adulterated product 12.32 10.75 15 727227 243 62761537
Polyomavirus-associated nephropathy 12.31 10.75 3 727239 1845 62759935
Gastritis 12.30 10.75 329 726913 36974 62724806
Nasal congestion 12.28 10.75 892 726350 64768 62697012
Balance disorder 12.27 10.75 1125 726117 83297 62678483
Infusion site haematoma 12.26 10.75 16 727226 279 62761501
Exposure to SARS-CoV-2 12.24 10.75 46 727196 1705 62760075
Infusion site discolouration 12.23 10.75 29 727213 828 62760952
Tongue disorder 12.23 10.75 71 727171 10509 62751271
Device leakage 12.23 10.75 41 727201 7055 62754725
Intermenstrual bleeding 12.20 10.75 48 727194 7878 62753902
Forced expiratory volume decreased 12.19 10.75 24 727218 4944 62756836
Low density lipoprotein increased 12.18 10.75 35 727207 6322 62755458
Prothrombin time ratio decreased 12.16 10.75 22 727220 516 62761264
Rheumatoid factor positive 12.15 10.75 1124 726118 83282 62678498
Neutrophil count decreased 12.15 10.75 525 726717 55881 62705899
Invasive ductal breast carcinoma 12.13 10.75 40 727202 6918 62754862
Pleural effusion 12.12 10.75 911 726331 92299 62669481
Toxicologic test abnormal 12.08 10.75 26 727216 695 62761085
Psychomotor skills impaired 12.07 10.75 6 727236 2362 62759418
Nitrite urine present 12.02 10.75 33 727209 1033 62760747
Full blood count abnormal 12.01 10.75 274 726968 31443 62730337
Renal ischaemia 11.98 10.75 24 727218 609 62761171
Pancreatitis 11.98 10.75 450 726792 48605 62713175
Incision site swelling 11.97 10.75 14 727228 217 62761563
Antipsychotic drug level increased 11.95 10.75 13 727229 3422 62758358
Nerve root injury 11.92 10.75 7 727235 37 62761743
Foot deformity 11.90 10.75 236 727006 27617 62734163
Adenovirus infection 11.89 10.75 14 727228 3557 62758223
Cystitis 11.87 10.75 756 726486 54235 62707545
Cystitis haemorrhagic 11.87 10.75 18 727224 4105 62757675
Intestinal haemorrhage 11.86 10.75 16 727226 3831 62757949
Chronic sinusitis 11.86 10.75 210 727032 12633 62749147
Small fibre neuropathy 11.85 10.75 20 727222 443 62761337
Treatment failure 11.83 10.75 2052 725190 196991 62564789
Amenorrhoea 11.75 10.75 66 727176 9848 62751932
Device related thrombosis 11.75 10.75 46 727196 1739 62760041
Nocardiosis 11.70 10.75 4 727238 1972 62759808
Kidney infection 11.68 10.75 348 726894 22828 62738952
Withdrawal syndrome 11.65 10.75 160 727082 19837 62741943
Arthrodesis 11.64 10.75 9 727233 2792 62758988
Arrhythmia 11.64 10.75 340 726902 37800 62723980
Haemorrhage intracranial 11.60 10.75 98 727144 13321 62748459
Bradyphrenia 11.57 10.75 41 727201 6939 62754841
Pulmonary embolism 11.54 10.75 1165 726077 115519 62646261
Atonic urinary bladder 11.53 10.75 9 727233 81 62761699
Renal papillary necrosis 11.52 10.75 15 727227 261 62761519
Stress 11.48 10.75 906 726336 66261 62695519
Spinal cord injury 11.45 10.75 29 727213 864 62760916
Monocyte percentage increased 11.45 10.75 34 727208 1114 62760666
Gastric cancer 11.43 10.75 23 727219 4700 62757080
Drug level below therapeutic 11.39 10.75 95 727147 4771 62757009
Blood prolactin increased 11.39 10.75 14 727228 3489 62758291
Focal dyscognitive seizures 11.38 10.75 10 727232 2911 62758869
Band neutrophil count increased 11.38 10.75 18 727224 377 62761403
Constipation 11.37 10.75 2822 724420 222121 62539659
Post procedural pulmonary embolism 11.35 10.75 15 727227 265 62761515
Substance abuse 11.34 10.75 94 727148 4713 62757067
Venoocclusive liver disease 11.31 10.75 24 727218 4811 62756969
Product use in unapproved indication 11.31 10.75 1840 725402 177240 62584540
Device related infection 11.30 10.75 194 727048 23198 62738582
Infusion site warmth 11.28 10.75 46 727196 1772 62760008
Vitamin K deficiency 11.25 10.75 19 727223 421 62761359
Acidosis 11.21 10.75 186 727056 11047 62750733
Liver transplant 11.21 10.75 54 727188 2237 62759543
Sinus node dysfunction 11.18 10.75 23 727219 4662 62757118
Concomitant disease aggravated 11.16 10.75 60 727182 9052 62752728
Feeling abnormal 11.16 10.75 1509 725733 146883 62614897
pH urine increased 11.14 10.75 18 727224 384 62761396
Shock haemorrhagic 11.12 10.75 67 727175 9828 62751952
Renal cancer 11.12 10.75 30 727212 5532 62756248
Hernia 11.04 10.75 204 727038 12370 62749410
Haematoma 10.99 10.75 309 726933 34511 62727269
Epstein-Barr virus associated lymphoproliferative disorder 10.93 10.75 4 727238 1890 62759890
Migraine with aura 10.92 10.75 61 727181 2679 62759101
Hypertriglyceridaemia 10.90 10.75 36 727206 6223 62755557
Spinal epidural haematoma 10.88 10.75 33 727209 1094 62760686
Purtscher retinopathy 10.86 10.75 9 727233 89 62761691
Drug level increased 10.82 10.75 339 726903 22397 62739383
Pustular psoriasis 10.79 10.75 23 727219 4603 62757177
BK virus infection 10.77 10.75 13 727229 3266 62758514
Pharyngitis streptococcal 10.76 10.75 177 727065 10495 62751285

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 680.62 10.95 3439 294597 196923 34461972
Infusion related reaction 644.62 10.95 1408 296628 51649 34607246
Completed suicide 571.03 10.95 1988 296048 96180 34562715
Exposure to toxic agent 402.43 10.95 297 297739 3378 34655517
Blood pressure fluctuation 366.21 10.95 721 297315 24528 34634367
Heart rate decreased 242.83 10.95 707 297329 31038 34627857
Overdose 241.80 10.95 1464 296572 89595 34569300
Blood pressure increased 217.33 10.95 1390 296646 86712 34572183
Acute hepatic failure 215.14 10.95 411 297625 13663 34645232
Drug interaction 176.96 10.95 1164 296872 224782 34434113
Intentional overdose 175.37 10.95 788 297248 42886 34616009
Intentional product misuse 169.88 10.95 805 297231 44806 34614089
Chills 141.28 10.95 1177 296859 79866 34579029
Blood pressure diastolic abnormal 137.54 10.95 187 297849 4631 34654264
Drug resistance 135.26 10.95 28 298008 25899 34632996
Oxygen saturation decreased 128.85 10.95 843 297193 52975 34605920
Methaemoglobinaemia 122.54 10.95 152 297884 3429 34655466
Sinusitis 119.02 10.95 680 297356 40722 34618173
Blood pressure systolic increased 118.04 10.95 447 297589 22505 34636390
Cardiac failure 116.16 10.95 394 297642 90854 34568041
Drug ineffective 114.78 10.95 2993 295043 453758 34205137
Blood pressure systolic abnormal 100.44 10.95 145 297891 3803 34655092
Myocardial infarction 93.48 10.95 626 297410 120459 34538436
Cytokine release syndrome 93.47 10.95 415 297621 22462 34636433
Hepatic cytolysis 93.26 10.95 304 297732 14192 34644703
Intentional product use issue 86.37 10.95 834 297202 58982 34599913
Anaphylactic reaction 82.24 10.95 514 297522 31787 34627108
Anaemia 80.34 10.95 1453 296583 231882 34427013
Anion gap 79.39 10.95 63 297973 804 34658091
Analgesic drug level increased 77.95 10.95 62 297974 794 34658101
Blood pressure diastolic increased 75.87 10.95 146 297890 4879 34654016
Infusion site extravasation 75.37 10.95 134 297902 4210 34654685
COVID-19 74.28 10.95 998 297038 76552 34582343
Metabolic acidosis 73.20 10.95 629 297407 43051 34615844
Interstitial lung disease 72.53 10.95 298 297738 64984 34593911
Coagulopathy 69.84 10.95 344 297692 19445 34639450
Body temperature decreased 69.63 10.95 257 297779 12777 34646118
Renal impairment 69.27 10.95 496 297540 94017 34564878
Myelosuppression 69.20 10.95 39 297997 19226 34639669
Bone marrow failure 68.74 10.95 89 297947 29164 34629731
Accidental overdose 66.78 10.95 344 297692 19796 34639099
Treatment failure 66.18 10.95 192 297844 46505 34612390
Hypotension 64.58 10.95 2403 295633 219246 34439649
Cardiac failure congestive 64.47 10.95 430 297606 82840 34576055
Heart rate increased 62.44 10.95 637 297399 45706 34613189
Back pain 61.22 10.95 1414 296622 120375 34538520
Local anaesthetic systemic toxicity 60.66 10.95 36 298000 274 34658621
General physical health deterioration 57.21 10.95 760 297276 127509 34531386
Pyroglutamic acidosis 57.21 10.95 39 297997 387 34658508
Diarrhoea 56.61 10.95 2733 295303 387179 34271716
Anaesthetic complication 56.19 10.95 58 297978 1062 34657833
Sopor 55.78 10.95 17 298019 12119 34646776
Infusion site swelling 54.67 10.95 86 297950 2438 34656457
Flushing 53.34 10.95 465 297571 31955 34626940
Urticaria 51.43 10.95 782 297254 61595 34597300
Foetal exposure during pregnancy 50.18 10.95 162 297874 37939 34620956
Infusion site pain 49.91 10.95 105 297931 3746 34655149
Body temperature increased 49.72 10.95 285 297751 17083 34641812
Respiratory depression 49.44 10.95 271 297765 15974 34642921
Therapeutic product effect incomplete 49.34 10.95 242 297794 50299 34608596
Heart rate irregular 48.98 10.95 265 297771 15542 34643353
Medication error 48.67 10.95 379 297657 25186 34633709
Labelled drug-drug interaction medication error 48.48 10.95 34 298002 14905 34643990
Throat irritation 47.84 10.95 198 297838 10387 34648508
Cerebral infarction 47.38 10.95 102 297934 27353 34631542
Respiratory arrest 46.54 10.95 403 297633 27640 34631255
Pancytopenia 45.31 10.95 556 297480 94601 34564294
Prostate cancer 45.28 10.95 179 297857 39470 34619425
Haematotoxicity 44.53 10.95 8 298028 8186 34650709
Bladder cancer 44.25 10.95 44 297992 16234 34642661
Hepatotoxicity 43.99 10.95 324 297712 21161 34637734
Toxic anterior segment syndrome 43.87 10.95 52 297984 1117 34657778
Infusion site pruritus 43.80 10.95 44 297992 779 34658116
Malignant neoplasm progression 43.24 10.95 511 297525 87535 34571360
Poor venous access 43.09 10.95 119 297917 5064 34653831
Cytomegalovirus infection 42.73 10.95 100 297936 26035 34632860
Diabetes mellitus 42.06 10.95 231 297805 46642 34612253
Coronary artery disease 41.75 10.95 241 297795 48064 34610831
Ear infection 41.33 10.95 185 297851 10046 34648849
Pain 41.11 10.95 2136 295900 202539 34456356
Immune reconstitution inflammatory syndrome 40.75 10.95 12 298024 8747 34650148
Product prescribing error 40.55 10.95 84 297952 22843 34636052
Throat tightness 39.88 10.95 159 297877 8199 34650696
Leukopenia 39.46 10.95 344 297692 62512 34596383
Blood pressure diastolic decreased 39.45 10.95 168 297868 8926 34649969
Hyperkalaemia 39.16 10.95 390 297646 68999 34589896
Cerebral haemorrhage 39.09 10.95 159 297877 34778 34624117
Acute kidney injury 38.61 10.95 2167 295869 302821 34356074
Inappropriate schedule of product administration 37.96 10.95 744 297292 61552 34597343
Nasopharyngitis 37.84 10.95 821 297215 69147 34589748
Wrong technique in product usage process 37.06 10.95 169 297867 35817 34623078
Progressive multifocal leukoencephalopathy 36.18 10.95 19 298017 9745 34649150
Renal cortical necrosis 35.77 10.95 23 298013 205 34658690
Hypoxia 34.93 10.95 662 297374 54433 34604462
Oesophageal carcinoma 34.63 10.95 18 298018 9286 34649609
Disease progression 34.62 10.95 681 297355 107396 34551499
Multiple-drug resistance 33.57 10.95 3 298033 5236 34653659
Pharyngeal paraesthesia 33.51 10.95 35 298001 650 34658245
Respiratory rate increased 33.50 10.95 170 297866 9724 34649171
Hepatic necrosis 33.43 10.95 89 297947 3705 34655190
Graft versus host disease 33.06 10.95 25 298011 10544 34648351
Rhabdomyolysis 32.92 10.95 397 297639 67766 34591129
Unresponsive to stimuli 32.50 10.95 369 297667 27200 34631695
C-reactive protein abnormal 32.20 10.95 17 298019 8693 34650202
Post transplant lymphoproliferative disorder 32.14 10.95 8 298028 6520 34652375
Lymphocyte count abnormal 31.95 10.95 45 297991 1153 34657742
Substance abuse 31.50 10.95 139 297897 7502 34651393
Product dose omission issue 31.27 10.95 779 297257 118932 34539963
Infusion site erythema 30.66 10.95 63 297973 2210 34656685
Pemphigus 30.49 10.95 52 297984 1579 34657316
Stress 30.46 10.95 394 297642 29953 34628942
Psoriasis 29.23 10.95 202 297834 38610 34620285
Contraindicated product administered 29.22 10.95 90 297946 21391 34637504
Thrombocytopenia 28.90 10.95 1065 296971 155182 34503713
Anhedonia 28.31 10.95 134 297902 7451 34651444
Melaena 28.22 10.95 181 297855 35199 34623696
Infusion site bruising 27.62 10.95 33 298003 715 34658180
Venoocclusive liver disease 27.38 10.95 17 298019 7949 34650946
Rhinalgia 27.26 10.95 39 297997 1014 34657881
Body temperature fluctuation 27.11 10.95 50 297986 1617 34657278
Acute myocardial infarction 27.04 10.95 310 297726 53409 34605486
Liver injury 26.91 10.95 218 297818 14660 34644235
Suicide attempt 26.89 10.95 476 297560 38640 34620255
Mucosal inflammation 26.69 10.95 206 297830 38416 34620479
Electrocardiogram QT prolonged 26.65 10.95 222 297814 40730 34618165
Tachycardia 26.54 10.95 927 297109 83845 34575050
Poisoning 25.96 10.95 186 297850 12040 34646855
Osteonecrosis 25.95 10.95 55 297981 14835 34644060
Osteonecrosis of jaw 25.74 10.95 73 297963 17816 34641079
Pulmonary function test decreased 25.66 10.95 97 297939 4878 34654017
Therapeutic response shortened 25.62 10.95 128 297908 7276 34651619
Akathisia 25.60 10.95 19 298017 8090 34650805
Thrombotic microangiopathy 25.32 10.95 32 298004 10598 34648297
Therapy partial responder 25.00 10.95 27 298009 9589 34649306
Mydriasis 24.96 10.95 125 297911 7112 34651783
Accidental exposure to product by child 24.93 10.95 45 297991 1431 34657464
Diabetic ketoacidosis 24.92 10.95 75 297961 17957 34640938
Renal injury 24.75 10.95 172 297864 11023 34647872
Parkinsonism 24.51 10.95 20 298016 8118 34650777
Systemic infection 24.50 10.95 7 298029 5205 34653690
Intercepted product preparation error 24.42 10.95 3 298033 4075 34654820
Hepatocellular injury 24.27 10.95 102 297934 22109 34636786
Suspected suicide 24.01 10.95 92 297944 4656 34654239
Hypertriglyceridaemia 23.94 10.95 22 298014 8426 34650469
Headache 23.83 10.95 2003 296033 198632 34460263
Bronchospasm 23.80 10.95 165 297871 10566 34648329
Emotional distress 23.41 10.95 213 297823 14813 34644082
Poisoning deliberate 23.29 10.95 130 297906 7714 34651181
Syncope 22.83 10.95 599 297437 90852 34568043
Septic shock 22.58 10.95 454 297582 71380 34587515
Gastrointestinal haemorrhage 22.49 10.95 578 297458 87899 34570996
SARS-CoV-2 test positive 22.27 10.95 105 297931 5828 34653067
Blood pressure decreased 22.22 10.95 586 297450 50929 34607966
Pathogen resistance 22.12 10.95 29 298007 9453 34649442
Epilepsy 22.10 10.95 101 297935 21394 34637501
Infusion site rash 22.09 10.95 25 298011 510 34658385
Cardio-respiratory arrest 21.93 10.95 622 297414 54651 34604244
Illness 21.70 10.95 193 297843 13336 34645559
Hypomagnesaemia 21.68 10.95 104 297932 21747 34637148
Neutrophil percentage increased 21.49 10.95 48 297988 1785 34657110
Glycosylated haemoglobin increased 21.49 10.95 40 297996 11320 34647575
Angina pectoris 21.33 10.95 168 297868 31195 34627700
Apparent death 21.06 10.95 3 298033 3641 34655254
Oedema peripheral 20.96 10.95 822 297214 118990 34539905
Fear 20.88 10.95 157 297879 10319 34648576
Myocardial fibrosis 20.86 10.95 37 297999 1160 34657735
Hepatocellular carcinoma 20.75 10.95 20 298016 7489 34651406
Cytomegalovirus chorioretinitis 20.63 10.95 3 298033 3586 34655309
Immune effector cell-associated neurotoxicity syndrome 20.50 10.95 74 297962 3639 34655256
Hepatic function abnormal 20.43 10.95 261 297775 44102 34614793
Chronic graft versus host disease 20.32 10.95 6 298030 4367 34654528
Loss of personal independence in daily activities 20.19 10.95 183 297853 32996 34625899
Polyneuropathy 19.84 10.95 63 297973 14833 34644062
Cardiac arrest 19.76 10.95 1006 297030 95153 34563742
Therapeutic product effect decreased 19.70 10.95 195 297841 34548 34624347
Inadequate analgesia 19.68 10.95 63 297973 2912 34655983
Hospitalisation 19.61 10.95 354 297682 56548 34602347
Anion gap abnormal 19.59 10.95 15 298021 181 34658714
Cardiac failure chronic 19.53 10.95 23 298013 7856 34651039
Cough 19.44 10.95 1509 296527 148631 34510264
Injury 19.28 10.95 265 297771 20422 34638473
Incorrect drug administration rate 19.27 10.95 44 297992 1661 34657234
Generalised bullous fixed drug eruption 19.17 10.95 11 298025 78 34658817
Myopathy 19.05 10.95 44 297992 11510 34647385
Hypocalcaemia 18.99 10.95 125 297911 24164 34634731
Abdominal pain 18.87 10.95 1630 296406 161988 34496907
Altered state of consciousness 18.83 10.95 116 297920 22777 34636118
BK virus infection 18.70 10.95 13 298023 5725 34653170
Electrocardiogram QRS complex prolonged 18.66 10.95 87 297949 4807 34654088
Pancreatitis acute 18.56 10.95 152 297884 27989 34630906
Arthralgia 18.53 10.95 1687 296349 168354 34490541
Hypoglycaemia 18.49 10.95 341 297695 54299 34604596
Kidney transplant rejection 18.46 10.95 22 298014 7475 34651420
Haematuria 18.36 10.95 308 297728 49758 34609137
Delayed recovery from anaesthesia 18.34 10.95 28 298008 773 34658122
Gastric cancer 18.15 10.95 17 298019 6452 34652443
Chronic gastrointestinal bleeding 18.04 10.95 18 298018 316 34658579
Neutropenia 17.97 10.95 1124 296912 155654 34503241
Blood pH decreased 17.85 10.95 52 297984 2282 34656613
Head discomfort 17.82 10.95 76 297960 4040 34654855
Anaesthetic complication neurological 17.81 10.95 18 298018 321 34658574
Ductus arteriosus premature closure 17.79 10.95 16 298020 245 34658650
Pemphigoid 17.77 10.95 29 298007 8637 34650258
Anaphylactic shock 17.73 10.95 211 297825 15730 34643165
Hand deformity 17.52 10.95 5 298031 3720 34655175
Bronchopulmonary aspergillosis 17.49 10.95 65 297971 14594 34644301
Congestive cardiomyopathy 17.48 10.95 23 298013 7487 34651408
Blood creatine phosphokinase increased 17.43 10.95 273 297763 44584 34614311
Gynaecomastia 17.41 10.95 38 297998 10142 34648753
Injection site pain 17.40 10.95 231 297805 38774 34620121
Lactic acidosis 17.37 10.95 201 297835 34571 34624324
Alanine aminotransferase increased 17.33 10.95 849 297187 79966 34578929
C-reactive protein increased 17.27 10.95 341 297695 53757 34605138
Appendicolith 17.20 10.95 129 297907 8472 34650423
Epstein-Barr virus infection 17.11 10.95 24 298012 7604 34651291
Cystitis haemorrhagic 17.05 10.95 14 298022 5665 34653230
Floppy iris syndrome 16.97 10.95 17 298019 300 34658595
Aspergillus infection 16.91 10.95 51 297985 12203 34646692
Sleep disorder due to a general medical condition 16.78 10.95 12 298024 5209 34653686
Tooth infection 16.76 10.95 107 297929 6664 34652231
Eosinophilia 16.68 10.95 143 297893 26079 34632816
Febrile neutropenia 16.67 10.95 1369 296667 135480 34523415
Treatment noncompliance 16.66 10.95 156 297880 27944 34630951
Decreased appetite 16.55 10.95 1208 296828 165184 34493711
Rheumatoid arthritis 16.49 10.95 435 297601 37803 34621092
Vital functions abnormal 16.35 10.95 16 298020 274 34658621
Toxic epidermal necrolysis 16.17 10.95 267 297769 21379 34637516
Cytomegalovirus viraemia 16.06 10.95 24 298012 7406 34651489
Myocardial ischaemia 16.05 10.95 85 297951 17323 34641572
Urine sodium decreased 16.00 10.95 13 298023 172 34658723
Therapy non-responder 15.98 10.95 236 297800 38910 34619985
Haemolysis 15.96 10.95 121 297915 7973 34650922
Oculocardiac reflex 15.90 10.95 9 298027 62 34658833
Maternal exposure before pregnancy 15.83 10.95 26 298010 765 34658130
Lymphocyte percentage decreased 15.83 10.95 47 297989 2085 34656810
Viral mutation identified 15.80 10.95 3 298033 2951 34655944
Pulmonary fibrosis 15.77 10.95 92 297944 18304 34640591
Virologic failure 15.77 10.95 5 298031 3475 34655420
Croup infectious 15.76 10.95 18 298018 371 34658524
Nocardiosis 15.69 10.95 7 298029 3944 34654951
Psychiatric decompensation 15.68 10.95 3 298033 2934 34655961
Dermatitis exfoliative generalised 15.64 10.95 6 298030 3701 34655194
Second primary malignancy 15.60 10.95 27 298009 7859 34651036
Dehydration 15.55 10.95 928 297108 129041 34529854
Device leakage 15.45 10.95 20 298016 6555 34652340
Oropharyngeal pain 15.40 10.95 404 297632 35081 34623814
Vitreous disorder 15.38 10.95 10 298026 91 34658804
Depressed level of consciousness 15.33 10.95 476 297560 42365 34616530
Colorectal cancer 15.23 10.95 11 298025 4750 34654145
Enterocolitis infectious 15.18 10.95 40 297996 1655 34657240
Eyelid rash 15.16 10.95 8 298028 47 34658848
Pneumocystis jirovecii pneumonia 15.13 10.95 102 297934 19608 34639287
Oral pruritus 15.12 10.95 16 298020 302 34658593
Acute graft versus host disease 15.05 10.95 20 298016 6483 34652412
Infusion site haemorrhage 14.95 10.95 29 298007 975 34657920
Sleep disorder due to general medical condition, insomnia type 14.92 10.95 34 298002 1282 34657613
Pyrexia 14.85 10.95 3133 294903 329880 34329015
Neck pain 14.85 10.95 301 297735 25048 34633847
Acute myeloid leukaemia 14.81 10.95 93 297943 18177 34640718
Immunosuppressant drug level increased 14.66 10.95 18 298018 6037 34652858
Hepatic cirrhosis 14.63 10.95 87 297949 17227 34641668
Hyperaesthesia 14.60 10.95 78 297958 4552 34654343
Transplant failure 14.58 10.95 6 298030 3547 34655348
Infusion site discomfort 14.46 10.95 13 298023 199 34658696
Therapeutic response decreased 14.42 10.95 170 297866 29143 34629752
Ejection fraction decreased 14.27 10.95 100 297936 19054 34639841
Pleural thickening 14.24 10.95 17 298019 368 34658527
Hepatitis C 14.23 10.95 40 297996 9790 34649105
Unintentional medical device removal 14.17 10.95 3 298033 2733 34656162
Transplant rejection 14.16 10.95 43 297993 10268 34648627
Product used for unknown indication 14.16 10.95 28 298008 955 34657940
Disturbance in attention 14.14 10.95 147 297889 25798 34633097
Rhinorrhoea 14.12 10.95 302 297734 25366 34633529
COVID-19 immunisation 14.07 10.95 14 298022 245 34658650
Hyperhidrosis 13.97 10.95 784 297252 74908 34583987
Migraine 13.96 10.95 218 297818 17260 34641635
Stevens-Johnson syndrome 13.96 10.95 230 297806 18409 34640486
Psychomotor skills impaired 13.89 10.95 8 298028 3898 34654997
Foetal growth restriction 13.85 10.95 9 298027 4108 34654787
Serum sickness 13.83 10.95 43 297993 1957 34656938
Erectile dysfunction 13.82 10.95 111 297925 20526 34638369
Hypertensive urgency 13.75 10.95 13 298023 213 34658682
Chest discomfort 13.67 10.95 582 297454 53948 34604947
Upper respiratory tract infection 13.66 10.95 374 297662 32685 34626210
Metastases to liver 13.57 10.95 65 297971 13598 34645297
Cytopenia 13.55 10.95 59 297977 12664 34646231
Syringe issue 13.54 10.95 17 298019 5647 34653248
Granulomatosis with polyangiitis 13.51 10.95 31 298005 1174 34657721
Liver disorder 13.44 10.95 199 297837 32798 34626097
Fungal rhinitis 13.42 10.95 7 298029 40 34658855
Specific gravity urine decreased 13.40 10.95 9 298027 87 34658808
Dyspnoea at rest 13.39 10.95 8 298028 3820 34655075
Lung neoplasm malignant 13.36 10.95 90 297946 17305 34641590
Insurance issue 13.33 10.95 43 297993 1996 34656899
Bezoar 13.23 10.95 30 298006 1127 34657768
Gastroenteritis viral 13.22 10.95 105 297931 7019 34651876
Bone erosion 13.21 10.95 9 298027 4006 34654889
Sulphaemoglobinaemia 13.19 10.95 6 298030 24 34658871
Aplasia pure red cell 13.06 10.95 20 298016 6112 34652783
Extrapyramidal disorder 12.96 10.95 61 297975 12819 34646076
Cerebrovascular accident 12.90 10.95 591 297445 84220 34574675
Lagophthalmos 12.90 10.95 9 298027 93 34658802
Intracranial hypotension 12.90 10.95 13 298023 231 34658664
C-reactive protein decreased 12.89 10.95 42 297994 1960 34656935
Aspartate aminotransferase increased 12.88 10.95 704 297332 67079 34591816
Weight fluctuation 12.87 10.95 82 297954 5103 34653792
Hepatitis fulminant 12.81 10.95 70 297966 4120 34654775
Brain death 12.77 10.95 51 297985 2632 34656263
Suicidal ideation 12.76 10.95 255 297781 40133 34618762
Aminoaciduria 12.75 10.95 14 298022 276 34658619
Psychotic disorder 12.74 10.95 140 297896 24312 34634583
Sudden infant death syndrome 12.73 10.95 13 298023 235 34658660
Graft versus host disease in skin 12.65 10.95 9 298027 3916 34654979
Chemical burn 12.59 10.95 13 298023 238 34658657
Oxygen saturation abnormal 12.59 10.95 35 298001 1495 34657400
Myoglobin blood increased 12.58 10.95 5 298031 3018 34655877
Depression 12.57 10.95 688 297348 96410 34562485
Concomitant disease progression 12.57 10.95 3 298033 2515 34656380
Exposure via ingestion 12.49 10.95 44 297992 2137 34656758
Post concussion syndrome 12.39 10.95 10 298026 131 34658764
Palmar-plantar erythrodysaesthesia syndrome 12.35 10.95 88 297948 16707 34642188
Tuberculosis 12.34 10.95 35 298001 8542 34650353
Crystal urine present 12.33 10.95 18 298018 477 34658418
Neuropathy peripheral 12.31 10.95 582 297454 82681 34576214
Hepatitis B 12.29 10.95 20 298016 5963 34652932
Erysipelas 12.26 10.95 14 298022 4849 34654046
Prostate cancer stage IV 12.20 10.95 3 298033 2465 34656430
Cerebral artery thrombosis 12.19 10.95 23 298013 757 34658138
Fixed eruption 12.17 10.95 37 297999 1663 34657232
Psoriatic arthropathy 12.13 10.95 109 297927 19689 34639206
Pulmonary alveolar haemorrhage 12.07 10.95 29 298007 7483 34651412
Mental status changes 12.05 10.95 417 297619 37666 34621229
Acute graft versus host disease in skin 12.03 10.95 16 298020 5185 34653710
Obsessive-compulsive disorder 12.00 10.95 18 298018 5546 34653349
Photosensitivity reaction 11.98 10.95 48 297988 10546 34648349
Appendicitis 11.95 10.95 185 297851 14622 34644273
Shock haemorrhagic 11.88 10.95 53 297983 11301 34647594
Neuroleptic malignant syndrome 11.76 10.95 97 297939 17837 34641058
Injection site extravasation 11.73 10.95 53 297983 2889 34656006
Diabetes mellitus inadequate control 11.72 10.95 67 297969 13397 34645498
Apnoea 11.70 10.95 97 297939 6567 34652328
Nephrolithiasis 11.65 10.95 340 297696 29993 34628902
Consciousness fluctuating 11.65 10.95 29 298007 1158 34657737
Hospice care 11.65 10.95 100 297936 6840 34652055
Atrial fibrillation 11.61 10.95 892 297144 121501 34537394
Hypertension 11.60 10.95 1331 296705 135112 34523783
Proctalgia 11.54 10.95 86 297950 5637 34653258
Mania 11.46 10.95 42 297994 9469 34649426
Cauda equina syndrome 11.38 10.95 19 298017 567 34658328
Injection site swelling 11.36 10.95 55 297981 11472 34647423
Ventricular fibrillation 11.35 10.95 266 297770 22688 34636207
Vitreous degeneration 11.32 10.95 3 298033 0 34658895
Ductus arteriosus stenosis foetal 11.31 10.95 11 298025 187 34658708
Exposure to SARS-CoV-2 11.30 10.95 18 298018 516 34658379
Proteinuria 11.26 10.95 103 297933 18539 34640356
Hyperthyroidism 11.25 10.95 49 297987 10517 34648378
Myelodysplastic syndrome 11.23 10.95 107 297929 19101 34639794
Weight increased 11.21 10.95 930 297106 92103 34566792
Urethral valves 11.20 10.95 13 298023 273 34658622
Hepatitis B reactivation 11.18 10.95 10 298026 3881 34655014
Infusion site nodule 11.14 10.95 9 298027 118 34658777
Prothrombin time prolonged 11.13 10.95 126 297910 9280 34649615
Bilirubin urine present 11.13 10.95 10 298026 153 34658742
Gastritis erosive 11.12 10.95 21 298015 5911 34652984
Delusion of grandeur 11.03 10.95 28 298008 1132 34657763
Administration site pruritus 10.99 10.95 5 298031 20 34658875
Anal sphincter atony 10.98 10.95 8 298028 89 34658806
Dependent personality disorder 10.98 10.95 8 298028 89 34658806
Psychomotor retardation 10.96 10.95 9 298027 3641 34655254
Apathy 10.95 10.95 27 298009 6905 34651990

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1846.48 10.46 6211 827952 239556 78670669
Toxicity to various agents 1776.30 10.46 8906 825257 412634 78497591
Exposure to toxic agent 1071.23 10.46 836 833327 8322 78901903
Infusion related reaction 1051.66 10.46 4982 829181 225255 78684970
Blood pressure fluctuation 775.41 10.46 1980 832183 65165 78845060
Acute hepatic failure 628.87 10.46 1130 833033 28983 78881242
Drug interaction 512.37 10.46 2416 831747 412767 78497458
Intentional overdose 485.32 10.46 2296 831867 103664 78806561
Intentional product misuse 473.57 10.46 2113 832050 93052 78817173
Overdose 426.97 10.46 3343 830820 180863 78729362
Blood pressure increased 417.47 10.46 3700 830463 207660 78702565
Heart rate decreased 370.92 10.46 1589 832574 68727 78841498
Rheumatoid arthritis 304.69 10.46 3429 830734 205041 78705184
Anaemia 300.72 10.46 3089 831074 441926 78468299
Sinusitis 295.89 10.46 3238 830925 192263 78717962
Blood pressure diastolic abnormal 286.57 10.46 626 833537 18576 78891649
Blood pressure systolic increased 267.23 10.46 1396 832767 65590 78844635
Cardiac failure 265.82 10.46 786 833377 154056 78756169
Drug resistance 257.94 10.46 62 834101 42151 78868074
Analgesic drug level increased 255.91 10.46 234 833929 2944 78907281
Oxygen saturation decreased 250.94 10.46 2252 831911 126795 78783430
Blood pressure systolic abnormal 238.01 10.46 545 833618 16702 78893523
Anion gap 237.69 10.46 191 833972 1990 78908235
Hepatic cytolysis 232.97 10.46 719 833444 26432 78883793
Local anaesthetic systemic toxicity 231.94 10.46 142 834021 912 78909313
Heart rate increased 224.19 10.46 2086 832077 118638 78791587
Nasopharyngitis 223.78 10.46 3816 830347 250065 78660160
Metabolic acidosis 216.64 10.46 1543 832620 80986 78829239
Acute kidney injury 209.81 10.46 3999 830164 515405 78394820
Pancytopenia 204.29 10.46 964 833199 164781 78745444
Throat irritation 198.22 10.46 902 833261 40044 78870181
Bone marrow failure 194.06 10.46 150 834013 50957 78859268
Intentional product use issue 193.07 10.46 2436 831727 149676 78760549
Sopor 193.02 10.46 53 834110 32957 78877268
Hepatotoxicity 185.74 10.46 1042 833121 50310 78859915
Muscle injury 173.41 10.46 982 833181 47579 78862646
Neutropenia 173.01 10.46 2050 832113 285660 78624565
Interstitial lung disease 171.99 10.46 602 833561 111998 78798227
Injection site pain 169.04 10.46 740 833423 129098 78781127
Irritable bowel syndrome 167.61 10.46 1171 832992 61070 78849155
Myelosuppression 162.46 10.46 111 834052 40185 78870040
Blood pressure diastolic decreased 155.58 10.46 678 833485 29538 78880687
Medication error 152.41 10.46 1234 832929 67408 78842817
Body temperature increased 151.25 10.46 887 833276 43533 78866692
Folliculitis 149.75 10.46 1043 833120 54337 78855888
Renal impairment 149.67 10.46 1000 833163 156783 78753442
Hyperkalaemia 148.91 10.46 652 833511 113746 78796479
Myocardial infarction 147.91 10.46 1223 832940 182906 78727319
Coagulopathy 147.47 10.46 756 833407 35250 78874975
Cardiac failure congestive 141.43 10.46 890 833273 141512 78768713
Duodenal ulcer perforation 140.94 10.46 1179 832984 65032 78845193
Osteonecrosis of jaw 138.93 10.46 148 834015 43078 78867147
Thrombocytopenia 137.68 10.46 1949 832214 263310 78646915
Weight increased 136.74 10.46 3835 830328 273551 78636674
Device expulsion 136.13 10.46 50 834113 25811 78884414
Blood pressure diastolic increased 134.08 10.46 395 833768 14147 78896078
Helicobacter infection 133.17 10.46 1212 832951 68492 78841733
Leukopenia 133.01 10.46 696 833467 115817 78794408
Malignant neoplasm progression 132.96 10.46 854 833309 135136 78775089
Sleep disorder due to general medical condition, insomnia type 130.19 10.46 841 833322 42715 78867510
General physical health deterioration 128.21 10.46 2065 832098 273173 78637052
Septic shock 127.42 10.46 757 833406 122044 78788181
Diarrhoea 122.15 10.46 7759 826404 872730 78037495
Hepatic enzyme increased 121.21 10.46 2629 831534 179981 78730244
Toxic anterior segment syndrome 120.97 10.46 147 834016 2617 78907608
Wrong technique in product usage process 118.92 10.46 386 833777 73489 78836736
Drug ineffective 118.49 10.46 9720 824443 1071193 77839032
COVID-19 117.44 10.46 2309 831854 155365 78754860
Disease progression 117.24 10.46 1297 832866 183065 78727160
Cytomegalovirus infection 116.03 10.46 166 833997 42478 78867747
Ill-defined disorder 115.65 10.46 1125 833038 64750 78845475
Injection site erythema 115.46 10.46 424 833739 77773 78832452
Pyroglutamic acidosis 114.65 10.46 93 834070 983 78909242
Lower respiratory tract infection 112.88 10.46 1940 832223 127280 78782945
Pain 112.04 10.46 8677 825486 695125 78215100
Haematotoxicity 104.76 10.46 18 834145 15501 78894724
Hyponatraemia 103.09 10.46 1277 832886 176571 78733654
Heart rate irregular 101.38 10.46 637 833526 32042 78878183
Respiratory depression 98.81 10.46 559 833604 27071 78883154
Blister 98.38 10.46 1777 832386 117699 78792526
Anaphylactic reaction 97.76 10.46 1321 832842 82422 78827803
Product prescribing error 97.60 10.46 201 833962 44612 78865613
Suicide attempt 94.68 10.46 1303 832860 81629 78828596
Rhabdomyolysis 94.60 10.46 660 833503 102471 78807754
Mucosal inflammation 90.50 10.46 444 833719 75136 78835089
Lactic acidosis 89.74 10.46 404 833759 69955 78840270
Cerebral infarction 89.56 10.46 217 833946 45459 78864766
Flushing 89.34 10.46 1358 832805 86910 78823315
Urine abnormality 89.31 10.46 237 833926 7982 78902243
Anti-cyclic citrullinated peptide antibody positive 88.78 10.46 1291 832872 81852 78828373
Hepatic necrosis 88.54 10.46 252 833911 8848 78901377
Infusion site extravasation 87.94 10.46 269 833894 9839 78900386
Urine leukocyte esterase positive 87.29 10.46 155 834008 3936 78906289
Product dose omission issue 86.90 10.46 1949 832214 245588 78664637
Urticaria 86.89 10.46 2545 831618 182656 78727569
Depressed level of consciousness 86.19 10.46 1456 832707 95196 78815029
Methaemoglobinaemia 86.16 10.46 184 833979 5373 78904852
Chills 84.45 10.46 2235 831928 157999 78752226
Poor venous access 84.28 10.46 395 833768 17754 78892471
Respiratory arrest 84.10 10.46 947 833216 56603 78853622
Accidental overdose 83.79 10.46 704 833459 38877 78871348
Arthralgia 83.62 10.46 7005 827158 564798 78345427
Ear pain 83.60 10.46 610 833553 32259 78877966
Body temperature decreased 83.16 10.46 599 833564 31546 78878679
Hypocalcaemia 83.05 10.46 257 833906 49667 78860558
Labelled drug-drug interaction medication error 83.05 10.46 100 834063 27550 78882675
Inappropriate schedule of product administration 83.02 10.46 1906 832257 131722 78778503
Back pain 81.47 10.46 3927 830236 300253 78609972
Discomfort 80.93 10.46 1801 832362 123816 78786409
Cytokine release syndrome 80.35 10.46 648 833515 35350 78874875
Blood calcium decreased 80.06 10.46 589 833574 31230 78878995
Infusion site pain 79.90 10.46 327 833836 13849 78896376
Electrocardiogram QT prolonged 78.28 10.46 588 833575 89798 78820427
Post transplant lymphoproliferative disorder 78.04 10.46 13 834150 11451 78898774
Injection site reaction 77.66 10.46 302 833861 54483 78855742
Prostate cancer 76.08 10.46 145 834018 33123 78877102
Psoriasis 76.07 10.46 586 833577 89001 78821224
Impaired healing 74.02 10.46 1309 832854 86346 78823879
Blood parathyroid hormone decreased 73.87 10.46 11 834152 10525 78899700
Sedation complication 73.47 10.46 342 833821 15327 78894898
Diabetes mellitus 70.75 10.46 504 833659 77886 78832339
Thrombotic microangiopathy 70.65 10.46 64 834099 20105 78890120
Hypokalaemia 70.60 10.46 1070 833093 142970 78767255
Agranulocytosis 70.59 10.46 238 833925 44792 78865433
Oesophageal carcinoma 70.27 10.46 15 834148 11069 78899156
Poisoning deliberate 70.04 10.46 385 833778 18443 78891782
Epilepsy 69.64 10.46 208 833955 40652 78869573
Hypotension 69.59 10.46 5427 828736 434890 78475335
Diabetic ketoacidosis 69.38 10.46 159 834004 33963 78876262
Cerebral haemorrhage 68.93 10.46 339 833824 57334 78852891
Headache 68.92 10.46 7828 826335 645944 78264281
Systemic infection 68.79 10.46 10 834153 9742 78900483
Pericarditis 67.94 10.46 1497 832666 102739 78807486
Joint swelling 67.58 10.46 3679 830484 284967 78625258
Ear pruritus 66.99 10.46 139 834024 3976 78906249
Injection site pruritus 66.62 10.46 223 833940 42060 78868165
Hand deformity 66.33 10.46 1488 832675 102431 78807794
Therapeutic response shortened 66.30 10.46 335 833828 15528 78894697
Decreased appetite 66.19 10.46 2917 831246 339501 78570724
Graft versus host disease 65.24 10.46 38 834125 14988 78895237
Respiratory rate increased 65.12 10.46 418 833745 21182 78889043
Infusion site swelling 65.05 10.46 205 833958 7621 78902604
Pneumocystis jirovecii pneumonia 64.88 10.46 153 834010 32355 78877870
Haematuria 64.87 10.46 437 833726 68399 78841826
Gastrointestinal haemorrhage 64.87 10.46 1120 833043 146599 78763626
Maternal exposure during delivery 64.54 10.46 75 834088 1271 78908954
Acute myocardial infarction 64.43 10.46 506 833657 76530 78833695
Pathogen resistance 64.09 10.46 35 834128 14307 78895918
Bladder cancer 63.70 10.46 66 834097 19460 78890765
Injection site bruising 63.40 10.46 218 833945 40784 78869441
Anaesthetic complication 63.18 10.46 110 834053 2749 78907476
Wound 62.79 10.46 1626 832537 114553 78795672
Hepatocellular injury 62.67 10.46 270 833893 47323 78862902
Weight fluctuation 62.43 10.46 265 833898 11410 78898815
Pemphigus 62.34 10.46 1422 832741 98160 78812065
White blood cells urine positive 61.82 10.46 171 833992 5904 78904321
Red blood cell sedimentation rate abnormal 61.71 10.46 77 834086 20886 78889339
Myelodysplastic syndrome 60.96 10.46 142 834021 30159 78880066
Body temperature fluctuation 60.12 10.46 127 834036 3680 78906545
Renal failure 59.98 10.46 1621 832542 199347 78710878
Injection site swelling 59.88 10.46 271 833892 46861 78863364
Infusion site pruritus 58.90 10.46 132 834031 3986 78906239
Posterior reversible encephalopathy syndrome 58.84 10.46 116 834047 26165 78884060
Infusion site erythema 58.79 10.46 225 833938 9235 78900990
Immune reconstitution inflammatory syndrome 58.69 10.46 36 834127 13805 78896420
Anion gap abnormal 58.36 10.46 51 834112 602 78909623
Peripheral swelling 58.34 10.46 3412 830751 266205 78644020
Coronary artery disease 58.09 10.46 423 833740 65051 78845174
Oropharyngeal pain 57.80 10.46 1526 832637 107827 78802398
Hypomagnesaemia 57.66 10.46 273 833890 46638 78863587
Therapeutic product effect incomplete 57.45 10.46 1089 833074 140556 78769669
Melaena 57.15 10.46 387 833776 60503 78849722
Granuloma skin 56.98 10.46 13 834150 9161 78901064
Acute lung injury 56.79 10.46 110 834053 2990 78907235
Hepatic function abnormal 56.67 10.46 490 833673 72617 78837608
Urinary sediment present 56.62 10.46 98 834065 2437 78907788
Product monitoring error 56.57 10.46 12 834151 8894 78901331
Oedema peripheral 56.47 10.46 2113 832050 250175 78660050
Syncope 56.30 10.46 1437 832726 178012 78732213
Creatinine renal clearance decreased 56.23 10.46 366 833797 18636 78891589
Liver injury 56.12 10.46 868 833295 55746 78854479
Multiple-drug resistance 55.68 10.46 12 834151 8796 78901429
Glossodynia 54.89 10.46 1443 832720 101894 78808331
Muscle spasticity 54.87 10.46 399 833764 21076 78889149
Bronchopulmonary aspergillosis 54.72 10.46 93 834070 22201 78888024
Transplant rejection 54.54 10.46 74 834089 19363 78890862
Panniculitis 54.11 10.46 31 834132 12340 78897885
Gastrointestinal disorder 53.43 10.46 1665 832498 120540 78789685
Contusion 52.93 10.46 1979 832184 146797 78763428
Crystal urine present 52.89 10.46 87 834076 2073 78908152
Aspergillus infection 52.71 10.46 74 834089 19087 78891138
Lymphocyte count decreased 52.35 10.46 739 833424 46550 78863675
Osteonecrosis 51.77 10.46 160 834003 30935 78879290
Suspected suicide 51.19 10.46 233 833930 10343 78899882
Palmar-plantar erythrodysaesthesia syndrome 50.67 10.46 177 833986 32957 78877268
Acute myeloid leukaemia 50.66 10.46 160 834003 30725 78879500
Hypersensitivity 50.48 10.46 3285 830878 258954 78651271
Colorectal cancer 50.33 10.46 14 834149 8633 78901592
Bursitis 50.20 10.46 585 833578 35259 78874966
Drug eruption 49.81 10.46 263 833900 43672 78866553
Cardio-respiratory arrest 49.74 10.46 1487 832676 107023 78803202
Lymphocyte percentage decreased 49.59 10.46 139 834024 4837 78905388
Platelet count decreased 48.92 10.46 1607 832556 193057 78717168
Injury 48.62 10.46 1107 833056 76389 78833836
Temperature regulation disorder 48.36 10.46 153 834010 5700 78904525
Pruritus 47.88 10.46 4771 829392 389877 78520348
Neutrophil percentage increased 47.73 10.46 132 834031 4557 78905668
Swelling 47.73 10.46 2747 831416 213964 78696261
Second primary malignancy 47.39 10.46 48 834115 14302 78895923
Urine analysis abnormal 47.23 10.46 163 834000 6357 78903868
Polyneuropathy 47.14 10.46 115 834048 24036 78886189
Stress 47.10 10.46 1128 833035 78484 78831741
Cytomegalovirus viraemia 46.95 10.46 39 834124 12782 78897443
Dehydration 46.14 10.46 2123 832040 246064 78664161
Neuropathy peripheral 46.08 10.46 1125 833038 140180 78770045
Poisoning 46.02 10.46 435 833728 24837 78885388
Illness 44.92 10.46 710 833453 45801 78864424
Chest discomfort 44.81 10.46 1818 832345 136226 78773999
Product use in unapproved indication 44.07 10.46 2154 832009 248205 78662020
Unintentional medical device removal 43.94 10.46 13 834150 7699 78902526
Skin necrosis 43.89 10.46 76 834087 18011 78892214
Acute graft versus host disease 43.73 10.46 26 834137 10141 78900084
Neuroleptic malignant syndrome 43.65 10.46 145 834018 27414 78882811
Hypercalcaemia 43.59 10.46 230 833933 38200 78872025
Red cell distribution width increased 43.53 10.46 291 833872 14951 78895274
Venoocclusive liver disease 42.87 10.46 36 834127 11735 78898490
Gastric cancer 42.43 10.46 27 834136 10152 78900073
Pyroglutamate increased 42.28 10.46 44 834119 655 78909570
Device use error 42.27 10.46 11 834152 7090 78903135
Skin toxicity 42.22 10.46 17 834146 8297 78901928
Hospitalisation 42.16 10.46 712 833451 93524 78816701
Epstein-Barr virus infection 41.35 10.46 54 834109 14362 78895863
Fatigue 41.32 10.46 10630 823533 919097 77991128
Neoplasm progression 41.13 10.46 344 833819 51338 78858887
Akathisia 40.84 10.46 47 834116 13212 78897013
Product substitution issue 40.69 10.46 95 834068 20161 78890064
Breast cancer stage I 40.62 10.46 10 834153 6690 78903535
Chronic graft versus host disease 39.43 10.46 11 834152 6770 78903455
Therapy cessation 39.23 10.46 231 833932 37331 78872894
Hepatocellular carcinoma 38.90 10.46 23 834140 8998 78901227
Blood pH decreased 38.79 10.46 123 834040 4588 78905637
Systemic lupus erythematosus 38.74 10.46 1593 832570 119556 78790669
Red blood cell sedimentation rate 38.58 10.46 6 834157 5559 78904666
Congestive cardiomyopathy 38.22 10.46 40 834123 11740 78898485
Febrile bone marrow aplasia 38.14 10.46 48 834115 12972 78897253
Food allergy 38.05 10.46 218 833945 10606 78899619
Inappropriate antidiuretic hormone secretion 37.97 10.46 144 834019 26169 78884056
Metastases to liver 37.66 10.46 160 834003 28154 78882071
Pharyngeal paraesthesia 37.56 10.46 86 834077 2635 78907590
Atrial fibrillation 37.52 10.46 1689 832474 196197 78714028
Hepatic cirrhosis 37.35 10.46 213 833950 34693 78875532
Rheumatoid nodule 37.31 10.46 79 834084 17359 78892866
Hepatitis B reactivation 37.26 10.46 9 834154 6099 78904126
Exposure via ingestion 37.17 10.46 129 834034 5045 78905180
Blood urine present 37.02 10.46 363 833800 20934 78889291
Substance abuse 37.00 10.46 212 833951 10314 78899911
Basal cell carcinoma 36.87 10.46 234 833929 37141 78873084
Therapeutic response decreased 36.86 10.46 485 833678 66368 78843857
Cytopenia 36.76 10.46 101 834062 20282 78889943
Cerebrovascular accident 36.67 10.46 1292 832871 154000 78756225
Electric shock 36.66 10.46 58 834105 1336 78908889
Myopathy 36.26 10.46 103 834060 20460 78889765
Blood creatine phosphokinase increased 36.24 10.46 480 833683 65610 78844615
Immunosuppressant drug level increased 36.21 10.46 25 834138 9002 78901223
Pancreatitis acute 36.02 10.46 338 833825 49266 78860959
Red blood cells urine positive 35.88 10.46 124 834039 4839 78905386
Incorrect drug administration rate 35.83 10.46 108 834055 3918 78906307
Altered state of consciousness 35.64 10.46 290 833873 43532 78866693
Nocardiosis 35.37 10.46 8 834155 5671 78904554
Kidney transplant rejection 35.31 10.46 33 834130 10213 78900012
Disturbance in social behaviour 35.28 10.46 5 834158 4965 78905260
Acute graft versus host disease in skin 35.24 10.46 18 834145 7640 78902585
Ascites 35.09 10.46 567 833596 74995 78835230
Graft versus host disease in skin 35.04 10.46 10 834153 6063 78904162
Injection site haemorrhage 34.95 10.46 161 834002 27709 78882516
Abortion spontaneous 34.94 10.46 174 833989 29333 78880892
Breast cancer female 34.90 10.46 41 834122 11420 78898805
Cardiac failure acute 34.73 10.46 93 834070 18836 78891389
Transplant dysfunction 34.71 10.46 16 834147 7205 78903020
Human herpesvirus 6 infection 34.60 10.46 7 834156 5363 78904862
Night sweats 34.51 10.46 750 833413 51345 78858880
BK virus infection 34.50 10.46 25 834138 8779 78901446
Product storage error 34.31 10.46 74 834089 16152 78894073
Specific gravity urine decreased 34.12 10.46 44 834119 834 78909391
Graft versus host disease in gastrointestinal tract 33.94 10.46 12 834151 6344 78903881
Cardiac failure chronic 33.73 10.46 40 834123 11095 78899130
Respiratory failure 33.71 10.46 1547 832616 179364 78730861
Bronchial secretion retention 33.65 10.46 107 834056 3997 78906228
Hyperglycaemia 33.59 10.46 525 833638 69810 78840415
Arthropathy 33.58 10.46 2216 831947 174895 78735330
Metastases to lung 33.51 10.46 89 834074 18074 78892151
Cystitis haemorrhagic 33.46 10.46 28 834135 9144 78901081
Diffuse large B-cell lymphoma 33.34 10.46 47 834116 12102 78898123
Sudden infant death syndrome 33.29 10.46 26 834137 259 78909966
Culture urine positive 33.11 10.46 112 834051 4323 78905902
SARS-CoV-2 test positive 33.05 10.46 223 833940 11493 78898732
Disorientation 32.95 10.46 460 833703 62316 78847909
Shock haemorrhagic 32.84 10.46 104 834059 19956 78890269
Device malfunction 32.51 10.46 115 834048 21333 78888892
Throat tightness 32.46 10.46 440 833723 27467 78882758
Brain death 32.03 10.46 131 834032 5546 78904679
Infusion site bruising 31.95 10.46 85 834078 2867 78907358
Drug reaction with eosinophilia and systemic symptoms 31.89 10.46 476 833687 63768 78846457
Renal cancer 31.89 10.46 49 834114 12177 78898048
Parkinsonism 31.56 10.46 80 834083 16504 78893721
Therapy interrupted 31.54 10.46 195 833968 31146 78879079
Hypertriglyceridaemia 31.40 10.46 53 834110 12687 78897538
Bacterial test 30.95 10.46 50 834113 1173 78909052
Sexual dysfunction 30.48 10.46 22 834141 7741 78902484
Subdural haematoma 30.39 10.46 198 833965 31236 78878989
Vital capacity decreased 30.34 10.46 62 834101 1754 78908471
Prothrombin time prolonged 30.34 10.46 290 833873 16609 78893616
Virologic failure 30.26 10.46 4 834159 4187 78906038
Unresponsive to stimuli 30.19 10.46 781 833382 55007 78855218
Injection site warmth 30.10 10.46 69 834094 14738 78895487
Hypoglycaemia 29.89 10.46 821 833342 100773 78809452
Hypersensitivity vasculitis 29.52 10.46 18 834145 6925 78903300
Pleural thickening 29.42 10.46 83 834080 2899 78907326
Anaesthetic complication neurological 29.41 10.46 35 834128 609 78909616
Ischaemic stroke 29.41 10.46 214 833949 32917 78877308
Hyperammonaemia 29.37 10.46 44 834119 11049 78899176
Anxiety 29.33 10.46 2999 831164 245513 78664712
Lymphoproliferative disorder 29.31 10.46 11 834152 5604 78904621
Dysarthria 29.25 10.46 514 833649 67108 78843117
Lipodystrophy acquired 29.23 10.46 5 834158 4320 78905905
Synovitis 29.12 10.46 1889 832274 148845 78761380
Hypoglycaemic coma 29.06 10.46 7 834156 4753 78905472
Therapeutic product effect decreased 28.91 10.46 2038 832125 161825 78748400
Tardive dyskinesia 28.90 10.46 41 834122 10530 78899695
Disturbance in attention 28.57 10.46 367 833796 50434 78859791
Accidental exposure to product by child 28.44 10.46 81 834082 2845 78907380
Anterior spinal artery syndrome 28.39 10.46 18 834145 124 78910101
Hepatic failure 28.35 10.46 840 833323 60372 78849853
Torsade de pointes 28.31 10.46 105 834058 19207 78891018
Hypothyroidism 28.18 10.46 382 833781 52010 78858215
Device issue 28.15 10.46 167 833996 26941 78883284
Underdose 27.59 10.46 218 833945 32933 78877292
Specific gravity urine increased 27.59 10.46 29 834134 437 78909788
Eyelid rash 27.58 10.46 19 834144 153 78910072
Multiple organ dysfunction syndrome 27.57 10.46 1004 833159 119242 78790983
Device difficult to use 27.51 10.46 62 834101 13323 78896902
Pulmonary tuberculosis 27.50 10.46 25 834138 7840 78902385
Anticipatory anxiety 27.49 10.46 47 834116 1157 78909068
Infusion site mass 27.34 10.46 55 834108 1538 78908687
Fracture 27.30 10.46 126 834037 21675 78888550
Toxic skin eruption 27.24 10.46 130 834033 22163 78888062
Pneumonia 27.21 10.46 6305 827858 653941 78256284
Sputum culture positive 26.93 10.46 94 834069 3687 78906538
Therapy non-responder 26.88 10.46 747 833416 91558 78818667
Leukoencephalopathy 26.78 10.46 26 834137 7903 78902322
Intercepted product preparation error 26.68 10.46 3 834160 3557 78906668
Surgery 26.57 10.46 217 833946 32549 78877676
Therapy partial responder 26.55 10.46 93 834070 17304 78892921
Angina pectoris 26.47 10.46 381 833782 51351 78858874
Potentiating drug interaction 26.37 10.46 32 834131 8787 78901438
Pancreatic carcinoma 26.22 10.46 65 834098 13512 78896713
Suicidal ideation 26.20 10.46 603 833560 75737 78834488
C-reactive protein increased 26.16 10.46 1093 833070 127934 78782291
Pulmonary alveolar haemorrhage 26.14 10.46 50 834113 11407 78898818
Renal cortical necrosis 26.09 10.46 25 834138 335 78909890
Device leakage 25.99 10.46 46 834117 10810 78899415
Anhedonia 25.93 10.46 254 833909 14644 78895581
Skin ulcer 25.92 10.46 404 833759 53746 78856479
Migraine 25.84 10.46 1141 833022 86352 78823873
Coeliac disease 25.69 10.46 205 833958 11146 78899079
Transient ischaemic attack 25.61 10.46 392 833771 52303 78857922
Extrapyramidal disorder 25.57 10.46 136 834027 22543 78887682
Bacterial test positive 25.51 10.46 149 834014 7300 78902925
Drug dose omission by device 25.48 10.46 17 834146 6233 78903992
Drug withdrawal syndrome 25.45 10.46 236 833927 34482 78875743
Peritonitis 25.41 10.46 180 833983 27856 78882369
Electrolyte imbalance 25.28 10.46 204 833959 30677 78879548
Proteinuria 25.11 10.46 218 833945 32284 78877941
Metastases to bone 25.10 10.46 151 834012 24276 78885949
Mucormycosis 25.04 10.46 31 834132 8438 78901787
Mania 25.02 10.46 102 834061 18158 78892067
Gynaecomastia 25.01 10.46 26 834137 7655 78902570
Aplasia pure red cell 24.80 10.46 27 834136 7783 78902442
Drug hypersensitivity 24.80 10.46 2742 831421 296174 78614051
Scoliosis 24.73 10.46 148 834015 7316 78902909
Dyspnoea at rest 24.60 10.46 24 834139 7278 78902947
Antipsychotic drug level increased 24.56 10.46 16 834147 5941 78904284
Monocyte percentage increased 24.56 10.46 63 834100 2078 78908147
Gestational diabetes 24.49 10.46 18 834145 6275 78903950
Varicella zoster virus infection 24.38 10.46 8 834155 4433 78905792
Anion gap increased 24.38 10.46 90 834073 3630 78906595
Fibromyalgia 24.37 10.46 862 833301 63478 78846747
Kounis syndrome 24.31 10.46 99 834064 4183 78906042
Erysipelas 24.19 10.46 48 834115 10802 78899423
Pleural fibrosis 24.18 10.46 97 834066 4070 78906155
Rheumatic fever 24.07 10.46 426 833737 28099 78882126
Injection site induration 24.06 10.46 41 834122 9778 78900447
Haematemesis 23.99 10.46 393 833770 51871 78858354
Blood magnesium increased 23.97 10.46 86 834077 3420 78906805
Cardiac arrest 23.89 10.46 2101 832062 169995 78740230
Dyskinesia 23.88 10.46 327 833836 44446 78865779
Multiple allergies 23.73 10.46 189 833974 10271 78899954
Glycosylated haemoglobin increased 23.71 10.46 112 834051 19148 78891077
Coma 23.54 10.46 1283 832880 99366 78810859
Condition aggravated 23.50 10.46 4755 829408 496369 78413856
Treatment noncompliance 23.35 10.46 395 833768 51873 78858352
Eosinophilia 23.19 10.46 334 833829 45011 78865214
Urine ketone body present 23.15 10.46 86 834077 3479 78906746
JC virus infection 23.13 10.46 6 834157 3875 78906350
Psychomotor skills impaired 23.08 10.46 13 834150 5224 78905001
Oral pruritus 23.05 10.46 67 834096 2381 78907844
Analgesic drug level above therapeutic 23.03 10.46 27 834136 462 78909763
Galactorrhoea 22.98 10.46 5 834158 3641 78906584
Genital haemorrhage 22.94 10.46 19 834144 6236 78903989
Infusion site discomfort 22.75 10.46 47 834116 1340 78908885
Rheumatoid lung 22.69 10.46 8 834155 4237 78905988
Pemphigoid 22.63 10.46 83 834080 15232 78894993
Lung neoplasm malignant 22.56 10.46 184 833979 27608 78882617
Haemophagocytic lymphohistiocytosis 22.43 10.46 135 834028 21702 78888523
Diffuse large B-cell lymphoma recurrent 22.37 10.46 8 834155 4199 78906026
Metastases to lymph nodes 22.33 10.46 47 834116 10350 78899875
Feeling hot 22.30 10.46 799 833364 58935 78851290
Cytomegalovirus chorioretinitis 22.29 10.46 15 834148 5475 78904750
Oxygen saturation abnormal 22.22 10.46 101 834062 4481 78905744
Brain stem glioma 22.21 10.46 18 834145 190 78910035
Pulmonary fibrosis 22.18 10.46 326 833837 43786 78866439
Dystonia 22.13 10.46 132 834031 21267 78888958
Epistaxis 22.11 10.46 947 833216 110568 78799657
Cough 22.11 10.46 4255 829908 362534 78547691
Hepatitis B 22.11 10.46 33 834130 8299 78901926
Tachycardia 22.08 10.46 2153 832010 175615 78734610
Cognitive disorder 22.01 10.46 918 833245 69008 78841217
Bronchospasm 21.97 10.46 374 833789 24485 78885740
Ketoacidosis 21.94 10.46 30 834133 7824 78902401
Infusion site haemorrhage 21.91 10.46 87 834076 3633 78906592
Intentional self-injury 21.82 10.46 225 833938 32194 78878031
Emotional distress 21.76 10.46 560 833603 39409 78870816
Vascular stent thrombosis 21.61 10.46 6 834157 3704 78906521
Osmolar gap 21.56 10.46 17 834146 172 78910053
White coat hypertension 21.55 10.46 35 834128 825 78909400
Presbyacusis 21.49 10.46 69 834094 2591 78907634
Lymphopenia 21.43 10.46 210 833953 30347 78879878
Ear infection 21.32 10.46 491 833672 33941 78876284
Adenovirus infection 20.95 10.46 35 834128 8412 78901813
Hepatitis C 20.83 10.46 60 834103 11865 78898360
Nasal congestion 20.80 10.46 990 833173 75562 78834663
Bilirubin urine present 20.75 10.46 22 834141 335 78909890
Acute myeloid leukaemia recurrent 20.60 10.46 5 834158 3378 78906847
Fungal rhinitis 20.52 10.46 12 834151 70 78910155
Angina unstable 20.41 10.46 96 834067 16431 78893794
Peripheral sensory neuropathy 20.35 10.46 69 834094 12964 78897261
Coronary artery bypass 20.33 10.46 20 834143 6042 78904183
Coronary arterial stent insertion 20.21 10.46 20 834143 6024 78904201
Gamma-glutamyltransferase increased 20.17 10.46 427 833736 54253 78855972
Haemoglobin urine present 20.14 10.46 36 834127 919 78909306
Upper respiratory tract infection 20.12 10.46 1156 833007 90012 78820213
Injection site mass 20.10 10.46 126 834037 20058 78890167
Neuralgia 20.04 10.46 474 833689 32910 78877315
Epstein-Barr virus associated lymphoproliferative disorder 20.04 10.46 6 834157 3526 78906699
Drug use disorder 20.00 10.46 157 834006 8494 78901731
Pneumonia aspiration 20.00 10.46 540 833623 66427 78843798
Nephrogenic systemic fibrosis 19.89 10.46 21 834142 6139 78904086
Hepatic cancer 19.88 10.46 51 834112 10478 78899747
Enthesopathy 19.84 10.46 59 834104 11549 78898676
Haemolysis 19.71 10.46 213 833950 12599 78897626
Hallucination, auditory 19.67 10.46 131 834032 20562 78889663
Bone erosion 19.58 10.46 108 834055 17739 78892486
Clostridium test positive 19.52 10.46 125 834038 6329 78903896
Haemorrhage 19.51 10.46 767 833396 90351 78819874
Intervertebral discitis 19.51 10.46 101 834062 4727 78905498
Infusion site rash 19.44 10.46 50 834113 1652 78908573
Atelectasis 19.37 10.46 458 833705 31799 78878426
Pneumatosis intestinalis 19.35 10.46 23 834140 6374 78903851
Renal injury 19.33 10.46 266 833897 16661 78893564
Progressive multifocal leukoencephalopathy 19.29 10.46 131 834032 20469 78889756
Sepsis 19.24 10.46 2496 831667 266932 78643293
Nerve block 19.22 10.46 30 834133 683 78909542
Product tampering 19.12 10.46 23 834140 405 78909820
COVID-19 immunisation 19.07 10.46 44 834119 1355 78908870
Cytomegalovirus infection reactivation 19.06 10.46 39 834124 8677 78901548
Renal papillary necrosis 19.03 10.46 23 834140 407 78909818
Hypertensive crisis 19.00 10.46 133 834030 20637 78889588
Generalised bullous fixed drug eruption 19.00 10.46 16 834147 179 78910046
Pleural effusion 18.97 10.46 1286 832877 143976 78766249
Drug tolerance 18.81 10.46 39 834124 8636 78901589
Fear 18.79 10.46 329 833834 21657 78888568
Cryopyrin associated periodic syndrome 18.74 10.46 22 834141 377 78909848
Abnormal loss of weight 18.72 10.46 37 834126 8339 78901886
Serum sickness 18.67 10.46 82 834081 3584 78906641
Blood creatinine decreased 18.64 10.46 143 834020 7682 78902543
Nephropathy toxic 18.55 10.46 131 834032 20288 78889937
Aggression 18.49 10.46 399 833764 50559 78859666
Lagophthalmos 18.48 10.46 23 834140 420 78909805
Circulatory collapse 18.38 10.46 280 833883 37388 78872837
Exposure to SARS-CoV-2 18.35 10.46 55 834108 1989 78908236
Tendonitis 18.34 10.46 160 834003 23670 78886555
Diabetic metabolic decompensation 18.30 10.46 6 834157 3326 78906899
Hernia 18.24 10.46 265 833898 16794 78893431
Nephrotic syndrome 18.24 10.46 58 834105 11116 78899109
Vein collapse 18.24 10.46 38 834125 1090 78909135
Sedation 18.13 10.46 689 833474 51206 78859019
Lupus vasculitis 18.11 10.46 26 834137 548 78909677
Reversible airways obstruction 18.09 10.46 57 834106 2119 78908106
Chronic kidney disease 18.09 10.46 540 833623 65614 78844611
Hyperthyroidism 18.04 10.46 147 834016 22062 78888163
Stomatitis 18.01 10.46 1776 832387 144981 78765244
Injection site urticaria 17.98 10.46 71 834092 12755 78897470
Injection site rash 17.92 10.46 112 834051 17842 78892383
Rhinorrhoea 17.84 10.46 970 833193 75104 78835121
Dermatitis exfoliative 17.83 10.46 56 834107 10773 78899452
Loss of personal independence in daily activities 17.75 10.46 884 833279 101696 78808529
Joint range of motion decreased 17.73 10.46 465 833698 32817 78877408
Drug level below therapeutic 17.71 10.46 168 833995 9602 78900623
Hypoxia 17.67 10.46 1281 832882 101962 78808263
Cerebral ischaemia 17.66 10.46 59 834104 11136 78899089
Erectile dysfunction 17.63 10.46 86 834077 14578 78895647
Dyspnoea exertional 17.56 10.46 738 833425 86335 78823890
Bradyphrenia 17.53 10.46 55 834108 10585 78899640
Secondary immunodeficiency 17.45 10.46 6 834157 3228 78906997
Hypocoagulable state 17.44 10.46 56 834107 2103 78908122
Hyperprolactinaemia 17.40 10.46 14 834149 4662 78905563
Hot flush 17.40 10.46 721 833442 54156 78856069
Eye infection 17.34 10.46 196 833967 11724 78898501
Visual acuity reduced 17.28 10.46 211 833952 29258 78880967
Polyomavirus-associated nephropathy 17.27 10.46 20 834143 5607 78904618
Incorrect dose administered by device 17.27 10.46 16 834147 4973 78905252
Rash pruritic 17.12 10.46 595 833568 71034 78839191
Right ventricular failure 17.11 10.46 160 834003 23337 78886888
Complications of transplanted kidney 17.10 10.46 25 834138 6341 78903884
Full blood count abnormal 17.07 10.46 309 833854 40165 78870060
Seizure 17.02 10.46 1722 832441 187112 78723113
Aqueous fibrin 17.02 10.46 13 834150 125 78910100
Infusion site urticaria 16.95 10.46 37 834126 1097 78909128
Immunodeficiency 16.94 10.46 321 833842 21447 78888778
Injection site extravasation 16.90 10.46 165 833998 9504 78900721
Pharyngitis streptococcal 16.89 10.46 179 833984 10535 78899690
Brain abscess 16.89 10.46 16 834147 4920 78905305
Influenza 16.87 10.46 1575 832588 128031 78782194
Corneal oedema 16.85 10.46 63 834100 2557 78907668
Neutrophil count decreased 16.78 10.46 807 833356 93152 78817073
Eosinophil percentage increased 16.72 10.46 44 834119 1474 78908751
Delusion 16.67 10.46 135 834028 20288 78889937
Suspected COVID-19 16.66 10.46 71 834092 3062 78907163
Tuberculosis 16.66 10.46 92 834071 15106 78895119
Haematoma 16.61 10.46 417 833746 51778 78858447
Concomitant disease aggravated 16.55 10.46 76 834087 13091 78897134
Jaundice 16.50 10.46 428 833735 52921 78857304
Upper gastrointestinal haemorrhage 16.50 10.46 319 833844 41061 78869164
Sinus operation 16.47 10.46 61 834102 2464 78907761
PO2 increased 16.46 10.46 45 834118 1543 78908682
Nitrite urine present 16.45 10.46 38 834125 1171 78909054
Blood pressure decreased 16.32 10.46 1230 832933 98236 78811989
Gene mutation 16.30 10.46 4 834159 2682 78907543
Drug screen positive 16.27 10.46 114 834049 5949 78904276
Multiple drug therapy 16.26 10.46 85 834078 3993 78906232
Klebsiella infection 16.24 10.46 97 834066 15623 78894602
Withdrawal syndrome 16.23 10.46 191 833972 26663 78883562
Mydriasis 16.16 10.46 267 833896 17376 78892849
Hypogammaglobulinaemia 16.13 10.46 75 834088 12876 78897349
Constipation 16.07 10.46 3274 830889 279776 78630449
Haematochezia 16.01 10.46 751 833412 86894 78823331
Transplant failure 15.93 10.46 15 834148 4626 78905599
Pulmonary arterial hypertension 15.92 10.46 205 833958 28161 78882064
Pulmonary hypertension 15.88 10.46 382 833781 47698 78862527
Prostate cancer stage IV 15.86 10.46 3 834160 2411 78907814
Maternal exposure during pregnancy 15.84 10.46 1646 832517 134892 78775333
Partial seizures 15.81 10.46 45 834118 8933 78901292
Hyperammonaemic encephalopathy 15.79 10.46 16 834147 4766 78905459
Administration site swelling 15.77 10.46 23 834140 492 78909733
Coronary artery stenosis 15.72 10.46 72 834091 12412 78897813
Anosognosia 15.67 10.46 10 834153 3754 78906471
Dizziness 15.67 10.46 5098 829065 521343 78388882
Salivary hypersecretion 15.65 10.46 86 834077 14138 78896087
Alanine aminotransferase increased 15.63 10.46 1936 832227 160634 78749591
Device dislocation 15.59 10.46 185 833978 25785 78884440
Subarachnoid haemorrhage 15.58 10.46 172 833991 24293 78885932
Arrhythmia 15.57 10.46 505 833658 60767 78849458
Swollen joint count increased 15.48 10.46 331 833832 22596 78887629
Neurotoxicity 15.43 10.46 243 833920 32275 78877950
Mean cell haemoglobin concentration decreased 15.30 10.46 91 834072 4488 78905737
Rash maculo-papular 15.27 10.46 458 833705 55620 78854605
Bacterial disease carrier 15.22 10.46 43 834120 1503 78908722
Glutathione decreased 15.19 10.46 9 834154 54 78910171
Cytomegalovirus colitis 15.10 10.46 16 834147 4669 78905556
Post-traumatic stress disorder 15.05 10.46 95 834068 4786 78905439
Fixed eruption 14.99 10.46 66 834097 2888 78907337
Lymphadenopathy 14.97 10.46 433 833730 52814 78857411
Renal disorder 14.90 10.46 331 833832 41774 78868451
Acidosis 14.89 10.46 290 833873 19472 78890753
Pneumonia cytomegaloviral 14.89 10.46 18 834145 4951 78905274
Pericardial haemorrhage 14.88 10.46 15 834148 4480 78905745
Prescribed underdose 14.88 10.46 218 833945 29296 78880929
Abnormal dreams 14.86 10.46 65 834098 11347 78898878
Hypomania 14.82 10.46 132 834031 7412 78902813
Syringe issue 14.80 10.46 27 834136 6271 78903954
Loss of consciousness 14.79 10.46 1534 832629 166409 78743816
Pleurothotonus 14.78 10.46 4 834159 2512 78907713
Dermatitis 14.75 10.46 147 834016 21174 78889051
Musculoskeletal stiffness 14.67 10.46 2067 832096 172941 78737284
Neovascularisation 14.66 10.46 37 834126 1208 78909017
Ventilation perfusion mismatch 14.63 10.46 25 834138 615 78909610
Catatonia 14.61 10.46 45 834118 8711 78901514
Cutaneous T-cell lymphoma 14.61 10.46 5 834158 2698 78907527
Psychotic symptom 14.56 10.46 5 834158 2692 78907533
Toxicologic test abnormal 14.56 10.46 39 834124 1321 78908904
Coagulation factor X level decreased 14.55 10.46 11 834152 104 78910121
Soft tissue disorder 14.53 10.46 74 834089 3441 78906784
Tenosynovitis 14.52 10.46 99 834064 15455 78894770
Cachexia 14.51 10.46 63 834100 11020 78899205
Dyspnoea 14.47 10.46 8463 825700 848562 78061663
Maternal exposure timing unspecified 14.44 10.46 107 834056 5685 78904540
Metastases to central nervous system 14.42 10.46 106 834057 16269 78893956
Disease recurrence 14.42 10.46 351 833812 43758 78866467
Atypical femur fracture 14.31 10.46 20 834143 5169 78905056
B-cell lymphoma 14.29 10.46 27 834136 6188 78904037
Squamous cell carcinoma of skin 14.28 10.46 87 834076 13946 78896279
Ejection fraction decreased 14.27 10.46 265 833898 34312 78875913
Blood creatinine increased 14.25 10.46 1412 832751 153645 78756580
Oculocardiac reflex 14.20 10.46 9 834154 62 78910163
Mobility decreased 14.20 10.46 1473 832690 120702 78789523
Ovarian hyperstimulation syndrome 14.18 10.46 10 834153 3561 78906664
Migraine with aura 14.16 10.46 61 834102 2644 78907581
Procedural hypotension 14.15 10.46 50 834113 1973 78908252
Gastroenteritis 14.13 10.46 261 833902 33821 78876404
Consciousness fluctuating 14.07 10.46 49 834114 1920 78908305
Polydipsia 14.07 10.46 30 834133 6575 78903650
Brain oedema 14.05 10.46 355 833808 24908 78885317
Peritonitis bacterial 14.03 10.46 52 834111 9515 78900710
Metabolic disorder 14.01 10.46 49 834114 9121 78901104
Sinus node dysfunction 14.01 10.46 38 834125 7663 78902562
Jaundice cholestatic 13.99 10.46 180 833983 11104 78899121
Drug tolerance decreased 13.99 10.46 79 834084 12899 78897326
Epigastric discomfort 13.93 10.46 135 834028 7761 78902464
Stoma site cellulitis 13.91 10.46 8 834155 45 78910180
Cardiovascular disorder 13.88 10.46 121 834042 17904 78892321
Intestinal haemorrhage 13.84 10.46 29 834134 6397 78903828
Nerve root injury 13.83 10.46 7 834156 29 78910196
Hypertension 13.77 10.46 3775 830388 327217 78583008
Dermatitis exfoliative generalised 13.73 10.46 35 834128 7206 78903019
Concussion 13.71 10.46 156 834007 9347 78900878
Respiratory disorder 13.69 10.46 587 833576 44269 78865956
Infusion site haematoma 13.68 10.46 16 834147 273 78909952
Fall 13.67 10.46 4733 829430 482896 78427329
Limb mass 13.66 10.46 74 834089 3525 78906700
Mycobacterial infection 13.63 10.46 11 834152 3657 78906568
Prostatic specific antigen increased 13.62 10.46 59 834104 10327 78899898
Prothrombin time ratio decreased 13.62 10.46 30 834133 895 78909330
pH urine increased 13.57 10.46 20 834143 432 78909793
Sensitisation 13.51 10.46 9 834154 3302 78906923
Hallucination 13.49 10.46 746 833417 84999 78825226
Incorrect dose administered 13.49 10.46 953 833210 75677 78834548
Facet joint syndrome 13.48 10.46 179 833984 11123 78899102
Urobilinogen urine increased 13.46 10.46 25 834138 658 78909567
Viral load increased 13.46 10.46 7 834156 2941 78907284
Immune effector cell-associated neurotoxicity syndrome 13.45 10.46 106 834057 5742 78904483
Urine bilirubin decreased 13.44 10.46 12 834151 146 78910079
Gastritis erosive 13.40 10.46 63 834100 10784 78899441
Polyarthritis 13.30 10.46 74 834089 12128 78898097
Acute coronary syndrome 13.29 10.46 149 834014 20984 78889241
Thinking abnormal 13.18 10.46 82 834081 13079 78897146
Hemiparesis 13.16 10.46 261 833902 33472 78876753
Blood immunoglobulin E increased 13.13 10.46 26 834137 5856 78904369
Neck pain 13.12 10.46 937 833226 74480 78835745
Spinal meningioma benign 13.10 10.46 10 834153 96 78910129
Mean arterial pressure decreased 13.09 10.46 18 834145 364 78909861
Cystitis 13.09 10.46 676 833487 52056 78858169
Tri-iodothyronine free increased 13.05 10.46 15 834148 251 78909974
Non-pitting oedema 12.99 10.46 8 834155 52 78910173
Paraesthesia ear 12.99 10.46 16 834147 289 78909936
Granulomatosis with polyangiitis 12.99 10.46 62 834101 2808 78907417
Portal hypertension 12.98 10.46 35 834128 7073 78903152
Toxoplasmosis 12.92 10.46 6 834157 2691 78907534
Trigemino-cardiac reflex 12.92 10.46 15 834148 254 78909971
Type IIa hyperlipidaemia 12.92 10.46 15 834148 254 78909971
Sinus tachycardia 12.89 10.46 490 833673 36418 78873807
Sulphaemoglobinaemia 12.87 10.46 8 834155 53 78910172
Rhinalgia 12.87 10.46 54 834109 2313 78907912
Abdominal discomfort 12.84 10.46 2886 831277 247841 78662384
Anaphylactic shock 12.83 10.46 479 833684 35517 78874708
Pharyngeal disorder 12.82 10.46 52 834111 2193 78908032
Acute graft versus host disease in intestine 12.80 10.46 14 834149 4027 78906198
Urine leukocyte esterase 12.79 10.46 13 834150 188 78910037
Administration site bruise 12.79 10.46 13 834150 188 78910037
Lip pruritus 12.78 10.46 29 834134 883 78909342
Fear of injection 12.77 10.46 38 834125 7436 78902789
Transferrin decreased 12.76 10.46 18 834145 373 78909852
Head discomfort 12.75 10.46 218 833945 14284 78895941
Osteolysis 12.75 10.46 17 834146 4481 78905744
Liver disorder 12.73 10.46 623 833540 71794 78838431
Post cholecystectomy syndrome 12.73 10.46 18 834145 374 78909851
Retinal vasculitis 12.71 10.46 37 834126 1316 78908909
Disseminated tuberculosis 12.70 10.46 15 834148 4168 78906057
Metabolic alkalosis 12.69 10.46 17 834146 4472 78905753
Unmasking of previously unidentified disease 12.61 10.46 3 834160 2054 78908171
Obsessive-compulsive disorder 12.56 10.46 27 834136 5900 78904325
Cestode infection 12.52 10.46 15 834148 263 78909962
Mycobacterium chelonae infection 12.51 10.46 5 834158 2451 78907774
Angioedema 12.43 10.46 659 833504 75376 78834849
Urethral obstruction 12.43 10.46 15 834148 265 78909960
Cerebral haematoma 12.43 10.46 42 834121 7900 78902325
Actinic keratosis 12.41 10.46 28 834135 6014 78904211
Hepatitis E 12.34 10.46 8 834155 2978 78907247
Cryptococcosis 12.33 10.46 11 834152 3482 78906743
Acquired gene mutation 12.30 10.46 4 834159 2229 78907996
Status epilepticus 12.26 10.46 186 833977 24855 78885370
Oedema 12.26 10.46 1080 833083 118500 78791725
Psychiatric decompensation 12.26 10.46 14 834149 3949 78906276
Blood triglycerides increased 12.20 10.46 151 834012 20889 78889336
Paresis 12.18 10.46 16 834147 4245 78905980
Tooth disorder 12.15 10.46 360 833803 25873 78884352
Physical disability 12.12 10.46 10 834153 3288 78906937
Enterococcal infection 12.11 10.46 105 834058 15555 78894670
Polycystic ovaries 12.07 10.46 13 834150 3766 78906459
Multiple sclerosis 12.07 10.46 312 833851 21970 78888255
Band neutrophil count increased 12.05 10.46 24 834139 666 78909559
White blood cell count decreased 12.05 10.46 1756 832407 186532 78723693
Oesophageal varices haemorrhage 12.01 10.46 16 834147 4220 78906005
Transfusion-related acute lung injury 11.93 10.46 15 834148 277 78909948
Cauda equina syndrome 11.89 10.46 37 834126 1366 78908859
Transfusion-related circulatory overload 11.85 10.46 17 834146 358 78909867
Cyst 11.79 10.46 207 833956 13633 78896592
Liver transplant 11.77 10.46 83 834080 4340 78905885
Forced expiratory volume decreased 11.77 10.46 42 834121 7772 78902453
Sudden cardiac death 11.75 10.46 23 834140 5202 78905023
Femoral neck fracture 11.75 10.46 59 834104 9925 78900300
Cardiomyopathy 11.72 10.46 221 833942 28553 78881672
Cerebral toxoplasmosis 11.72 10.46 5 834158 2357 78907868
Femur fracture 11.71 10.46 311 833852 38341 78871884
Hyperlipidaemia 11.71 10.46 197 833966 25896 78884329
Anal sphincter atony 11.69 10.46 16 834147 322 78909903
Acute psychosis 11.64 10.46 16 834147 4164 78906061
Insurance issue 11.62 10.46 101 834062 5632 78904593
Cells in urine 11.62 10.46 13 834150 211 78910014
Toxic encephalopathy 11.60 10.46 71 834092 11369 78898856
Purtscher retinopathy 11.58 10.46 10 834153 116 78910109
Abortion induced 11.54 10.46 37 834126 7072 78903153
Product used for unknown indication 11.53 10.46 39 834124 1505 78908720
Systemic candida 11.52 10.46 34 834129 6672 78903553
Disseminated intravascular coagulation 11.50 10.46 286 833877 35556 78874669
Treatment failure 11.49 10.46 1585 832578 168901 78741324
Upper-airway cough syndrome 11.48 10.46 179 833984 11514 78898711
Thoracic operation 11.48 10.46 13 834150 214 78910011
Meningitis chemical 11.43 10.46 13 834150 215 78910010
Loss of libido 11.36 10.46 7 834156 2678 78907547
Necrotic lymphadenopathy 11.34 10.46 9 834154 92 78910133
Skin exfoliation 11.32 10.46 466 833697 54634 78855591
Infusion site irritation 11.31 10.46 25 834138 748 78909477
Monoparesis 11.30 10.46 12 834151 3499 78906726
Delayed graft function 11.28 10.46 12 834151 3495 78906730
Blood glucose increased 11.26 10.46 1042 833121 113933 78796292
Stent placement 11.25 10.46 33 834130 6487 78903738
Enteritis 11.18 10.46 98 834065 14485 78895740
Monocyte count increased 11.16 10.46 165 833998 10496 78899729
Long QT syndrome 11.12 10.46 29 834134 5926 78904299
Lung carcinoma cell type unspecified stage IV 11.09 10.46 4 834159 2089 78908136
Haemorrhage intracranial 11.04 10.46 200 833963 25993 78884232
Drug ineffective for unapproved indication 11.03 10.46 431 833732 50807 78859418
Metastasis 11.03 10.46 36 834127 6844 78903381
Photosensitivity reaction 11.02 10.46 155 834008 20972 78889253
Embolia cutis medicamentosa 10.97 10.46 22 834141 614 78909611
Anterior chamber cell 10.96 10.46 28 834135 921 78909304
Blood uric acid decreased 10.95 10.46 34 834129 1254 78908971
Dermatitis allergic 10.94 10.46 129 834034 18001 78892224
Smear cervix abnormal 10.91 10.46 54 834109 2482 78907743
Autonomic dysreflexia 10.91 10.46 18 834145 430 78909795
Cardiotoxicity 10.89 10.46 79 834084 12160 78898065
Psychomotor retardation 10.89 10.46 31 834132 6153 78904072
Neoplasm recurrence 10.88 10.46 17 834146 4197 78906028
Accidental exposure to product 10.86 10.46 247 833916 31075 78879150
Vaccination site pain 10.86 10.46 12 834151 192 78910033
Deep vein thrombosis 10.85 10.46 1103 833060 119816 78790409
Euglycaemic diabetic ketoacidosis 10.84 10.46 36 834127 6808 78903417
Spinal cord injury 10.84 10.46 34 834129 1261 78908964
Viral haemorrhagic cystitis 10.82 10.46 4 834159 2057 78908168
Postoperative delirium 10.81 10.46 16 834147 347 78909878
Haemoptysis 10.80 10.46 477 833686 55522 78854703
Wound infection 10.78 10.46 328 833835 23663 78886562
Small fibre neuropathy 10.78 10.46 20 834143 526 78909699
Breast cancer stage II 10.73 10.46 46 834117 8074 78902151
Penile vascular disorder 10.71 10.46 3 834160 0 78910225
Persecutory delusion 10.70 10.46 22 834141 4887 78905338
Blood cholesterol increased 10.69 10.46 1016 833147 82704 78827521
Asthenia 10.68 10.46 5019 829144 506670 78403555
Medication overuse headache 10.63 10.46 27 834136 885 78909340
Catheter site bruise 10.62 10.46 18 834145 440 78909785
Faecaloma 10.60 10.46 74 834089 11490 78898735
Leukocyturia 10.59 10.46 45 834118 1938 78908287
Hyperuricaemia 10.57 10.46 76 834087 11723 78898502
Delayed recovery from anaesthesia 10.57 10.46 40 834123 1633 78908592
Left ventricular hypertrophy 10.56 10.46 71 834092 11120 78899105
Granulocytopenia 10.55 10.46 73 834090 11358 78898867
Cardiac disorder 10.55 10.46 571 833592 65186 78845039
Red blood cell spherocytes present 10.54 10.46 6 834157 33 78910192
Sinusitis fungal 10.54 10.46 51 834112 2323 78907902
Encephalitis viral 10.53 10.46 7 834156 2572 78907653
Iron deficiency anaemia 10.51 10.46 197 833966 25475 78884750
Anal fissure 10.47 10.46 125 834038 7578 78902647
Anti-erythrocyte antibody positive 10.47 10.46 8 834155 77 78910148
Orbital compartment syndrome 10.47 10.46 8 834155 77 78910148

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01CA06 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
Adrenergic and dopaminergic agents
ATC R01AA04 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Sympathomimetics, plain
ATC R01AB01 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Sympathomimetics, combinations excl. corticosteroids
ATC R01BA03 RESPIRATORY SYSTEM
NASAL PREPARATIONS
NASAL DECONGESTANTS FOR SYSTEMIC USE
Sympathomimetics
ATC R01BA53 RESPIRATORY SYSTEM
NASAL PREPARATIONS
NASAL DECONGESTANTS FOR SYSTEMIC USE
Sympathomimetics
ATC S01FB01 SENSORY ORGANS
OPHTHALMOLOGICALS
MYDRIATICS AND CYCLOPLEGICS
Sympathomimetics excl. antiglaucoma preparations
ATC S01FB51 SENSORY ORGANS
OPHTHALMOLOGICALS
MYDRIATICS AND CYCLOPLEGICS
Sympathomimetics excl. antiglaucoma preparations
ATC S01GA05 SENSORY ORGANS
OPHTHALMOLOGICALS
DECONGESTANTS AND ANTIALLERGICS
Sympathomimetics used as decongestants
ATC S01GA55 SENSORY ORGANS
OPHTHALMOLOGICALS
DECONGESTANTS AND ANTIALLERGICS
Sympathomimetics used as decongestants
FDA MoA N0000009917 Adrenergic alpha1-Agonists
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D058646 Adrenergic alpha-1 Receptor Agonists
MeSH PA D000316 Adrenergic alpha-Agonists
MeSH PA D002316 Cardiotonic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D009184 Mydriatics
MeSH PA D014663 Nasal Decongestants
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D020011 Protective Agents
MeSH PA D019141 Respiratory System Agents
MeSH PA D013566 Sympathomimetics
MeSH PA D014662 Vasoconstrictor Agents
CHEBI has role CHEBI:35524 sympathomimetic
CHEBI has role CHEBI:35569 alpha-adrenergic agonists
CHEBI has role CHEBI:38147 cardiotonic drugs
CHEBI has role CHEBI:50267 protective agents
CHEBI has role CHEBI:50513 mydriatics
CHEBI has role CHEBI:77715 nasal decongestants
FDA EPC N0000186105 alpha-1 Adrenergic Agonist

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Proctitis indication 3951002 DOID:3127
Sinus headache indication 4969004
Vasomotor rhinitis indication 8229003 DOID:4730
Dilated pupil indication 37125009
Cough indication 49727002
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Rhinitis indication 70076002 DOID:4483
Hemorrhoids indication 70153002 DOID:9746
Red eye indication 75705005
Sneezing indication 76067001
Rectal pain indication 77880009
Common cold indication 82272006 DOID:10459
Pruritus ani indication 90446007
Headache disorder indication 230461009
Influenza-like symptoms indication 315642008
Seasonal allergic rhinitis indication 367498001
Fever indication 386661006
Allergic conjunctivitis indication 473460002 DOID:11204
Prevention of intraoperative miosis indication
Prevention of Posterior Synechiae indication
Maintenance of intraoperative mydriasis indication
Postoperative ocular pain in intraocular lens replacement surgery indication
Priapism off-label use 6273006 DOID:9286
Low blood pressure off-label use 45007003
Metabolic alkalosis contraindication 1388004
Brain damage contraindication 2470005
Anuria contraindication 2472002 DOID:2983
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Goiter contraindication 3716002 DOID:12176
Ocular hypertension contraindication 4210003 DOID:9282
Gastritis contraindication 4556007 DOID:4029
Hypocalcemia contraindication 5291005
Tachyarrhythmia contraindication 6285003
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Urinary tract obstruction contraindication 7163005 DOID:5200
Alcoholism contraindication 7200002
Alcohol withdrawal delirium contraindication 8635005
Peptic ulcer contraindication 13200003 DOID:750
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Asthenia contraindication 13791008
Hyperkalemia contraindication 14140009
Severe chronic ulcerative colitis contraindication 14311001
Constipation contraindication 14760008 DOID:2089
Hyperbilirubinemia contraindication 14783006 DOID:2741
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Chronic disease of respiratory system contraindication 17097001
Mood swings contraindication 18963009
Pulmonary edema contraindication 19242006 DOID:11396
Lowered convulsive threshold contraindication 19260006
Hashimoto thyroiditis contraindication 21983002
Myocardial infarction contraindication 22298006 DOID:5844
Disorder of the central nervous system contraindication 23853001 DOID:331
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Ventricular tachycardia contraindication 25569003
Acute tuberculosis contraindication 25629007
Alcohol intoxication contraindication 25702006
Shock contraindication 27942005
Toxic megacolon contraindication 28536002 DOID:1770
Atony of colon contraindication 29479008
Hypercapnia contraindication 29596007
Bronchitis contraindication 32398004 DOID:6132
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Hypernatremia contraindication 39355002
Disorder of gallbladder contraindication 39621005 DOID:0060262
Gastrointestinal ulcer contraindication 40845000
Hypothyroidism contraindication 40930008 DOID:1459
Complete trisomy 21 syndrome contraindication 41040004 DOID:14250
Body fluid retention contraindication 43498006
Conduction disorder of the heart contraindication 44808001
Achalasia of esophagus contraindication 45564002 DOID:9164
Chronic heart failure contraindication 48447003
Anxiety contraindication 48694002
Bradycardia contraindication 48867003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Acidosis contraindication 51387008
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Paralytic ileus contraindication 55525008 DOID:8442
Heart disease contraindication 56265001 DOID:114
Peptic reflux disease contraindication 57643001
Acute nephropathy contraindication 58574008
Metabolic acidosis contraindication 59455009
Hepatic failure contraindication 59927004
Perforation of tympanic membrane contraindication 60442001
Ulcerative colitis contraindication 64766004 DOID:8577
Blood coagulation disorder contraindication 64779008 DOID:1247
Arterial thrombosis contraindication 65198009
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Psychotic disorder contraindication 69322001
Poisoning by acetaminophen contraindication 70273001
Agoraphobia contraindication 70691001 DOID:593
Arteriosclerotic vascular disease contraindication 72092001
Diabetes mellitus contraindication 73211009 DOID:9351
Sleep apnea contraindication 73430006 DOID:0050847
Factor II deficiency contraindication 73975000
Reye's syndrome contraindication 74351001 DOID:14525
Gastrointestinal hemorrhage contraindication 74474003
Urethral stricture contraindication 76618002
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Spastic paralysis contraindication 78403003
Disturbance of salivary secretion contraindication 78948009
Decreased respiratory function contraindication 80954004
Disorder of brain contraindication 81308009 DOID:936
Injury of head contraindication 82271004
Chronic idiopathic constipation contraindication 82934008
Oliguria contraindication 83128009
Cor pulmonale contraindication 83291003 DOID:8515
Hiatal hernia contraindication 84089009 DOID:12642
Epilepsy contraindication 84757009 DOID:1826
Pulmonary emphysema contraindication 87433001
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Thyrotoxicosis contraindication 90739004 DOID:7997
Hemophilia contraindication 90935002
Myasthenia gravis contraindication 91637004 DOID:437
Dermatitis herpetiformis contraindication 111196000 DOID:8505
Anemia due to enzyme deficiency contraindication 111577008
Acute abdominal pain contraindication 116290004
Procedure on urinary system contraindication 118677009
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Open wound contraindication 125643001
Gastrointestinal obstruction contraindication 126765001
Neoplasm of brain contraindication 126952004 DOID:1319
von Willebrand disorder contraindication 128105004 DOID:12531
Seizure disorder contraindication 128613002
Autonomic dysreflexia contraindication 129618003
Bleeding contraindication 131148009
Drug-induced psychosis contraindication 191483003 DOID:1742
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Partial atrioventricular block contraindication 195039008
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Myocardial dysfunction contraindication 233928007
Arterial aneurysm contraindication 233981004
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Hyporeninemic hypoaldosteronism contraindication 236464008
Bladder outflow obstruction contraindication 236645006
Morbid obesity contraindication 238136002 DOID:11981
Hypocomplementemic urticarial vasculitis contraindication 239945009
Rhabdomyolysis contraindication 240131006
Pyloric obstruction contraindication 244815007
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Drowsy contraindication 271782001
Peripheral edema contraindication 271809000
Exacerbation of asthma contraindication 281239006
Pregnancy, function contraindication 289908002
Lesion of brain contraindication 301766008
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Familial hyperkalemic periodic paralysis contraindication 304737009 DOID:14451
Bone marrow depression contraindication 307762000
Infective otitis media contraindication 312218008
Panic disorder contraindication 371631005 DOID:594
Coma contraindication 371632003
Primary adrenocortical insufficiency contraindication 373662000
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Operation on gastrointestinal tract contraindication 386621005
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Cardiovascular event risk contraindication 395112001
Pseudomembranous enterocolitis contraindication 397683000
Gastric ulcer contraindication 397825006 DOID:10808
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Chronic myocardial ischemia contraindication 413844008 DOID:3393
Disorder of coronary artery contraindication 414024009
Myocardial ischemia contraindication 414795007 DOID:3393
Traumatic injury contraindication 417746004
Myocardial infarction in recovery phase contraindication 418044006
Central nervous system depression contraindication 418072004
Porphyria contraindication 418470004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant contraindication 422681000
Dysfunction of sphincter of Oddi contraindication 430887001
Hypertensive urgency contraindication 443482000
Acute erosive gastritis contraindication 444926003
Azotemia contraindication 445009001
Severe dehydration contraindication 450316000
Acute exacerbation of asthma contraindication 708038006
Nervousness contraindication
Predisposition to Glaucoma contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.15 acidic
pKa2 13.64 acidic
pKa3 8.71 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 0.3% BASE;EQ 1% BASE OMIDRIA RAYNER SURGICAL N205388 May 30, 2014 RX SOLUTION IRRIGATION 8173707 July 30, 2023 MAINTAINING PUPIL SIZE BY PREVENTING INTRAOPERATIVE MIOSIS AND REDUCING POSTOPERATIVE OCULAR PAIN
EQ 0.3% BASE;EQ 1% BASE OMIDRIA RAYNER SURGICAL N205388 May 30, 2014 RX SOLUTION IRRIGATION 9278101 July 30, 2023 MAINTAINING PUPIL SIZE BY PREVENTING INTRAOPERATIVE MIOSIS AND REDUCING POSTOPERATIVE OCULAR PAIN
10% PHENYLEPHRINE HYDROCHLORIDE PARAGON BIOTECK N203510 March 21, 2013 RX SOLUTION/DROPS OPHTHALMIC 8859623 Nov. 14, 2033 DILATION OF THE PUPIL
2.5% PHENYLEPHRINE HYDROCHLORIDE PARAGON BIOTECK N203510 March 21, 2013 RX SOLUTION/DROPS OPHTHALMIC 8859623 Nov. 14, 2033 DILATION OF THE PUPIL

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
2.5% PHENYLEPHRINE HYDROCHLORIDE MANKIND PHARMA A216859 Sept. 29, 2022 RX SOLUTION/DROPS OPHTHALMIC April 5, 2023 COMPETITIVE GENERIC THERAPY
10% PHENYLEPHRINE HYDROCHLORIDE MANKIND PHARMA A216496 Jan. 11, 2023 RX SOLUTION/DROPS OPHTHALMIC July 17, 2023 COMPETITIVE GENERIC THERAPY
2.5%;1% MYDCOMBI EYENOVIA N215352 May 5, 2023 RX SPRAY, METERED OPHTHALMIC May 5, 2026 NEW PRODUCT

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Alpha-1A adrenergic receptor GPCR AGONIST Ki 5.30 WOMBAT-PK CHEMBL
Alpha-1D adrenergic receptor GPCR AGONIST IC50 5.90 WOMBAT-PK CHEMBL
Alpha-1B adrenergic receptor GPCR AGONIST Ki 6.90 WOMBAT-PK CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 6.41 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 4.89 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 6.03 CHEMBL
Alpha-1B adrenergic receptor GPCR Ki 5.90 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 6.57 CHEMBL
Adrenergic receptor alpha-1 GPCR Ki 5.21 CHEMBL
Alpha-1B adrenergic receptor GPCR EC50 8 CHEMBL

External reference:

IDSource
4017847 VUID
N0000146204 NUI
D00511 KEGG_DRUG
61-76-7 SECONDARY_CAS_RN
1416-03-1 SECONDARY_CAS_RN
17162-39-9 SECONDARY_CAS_RN
4017845 VANDF
4017847 VANDF
4018447 VANDF
4018824 VANDF
C0031469 UMLSCUI
CHEBI:8093 CHEBI
CHEMBL1215 ChEMBL_ID
DB00388 DRUGBANK_ID
CHEMBL1200339 ChEMBL_ID
CHEMBL2062264 ChEMBL_ID
D010656 MESH_DESCRIPTOR_UI
6041 PUBCHEM_CID
4174 INN_ID
485 IUPHAR_LIGAND_ID
1WS297W6MV UNII
221139 RXNORM
1307 MMSL
30342 MMSL
35410 MMSL
5282 MMSL
5283 MMSL
5284 MMSL
5285 MMSL
d00704 MMSL
001825 NDDF
001826 NDDF
001827 NDDF
001828 NDDF
372771005 SNOMEDCT_US
54765002 SNOMEDCT_US
68699004 SNOMEDCT_US
73946006 SNOMEDCT_US
784324003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Fresh Clear HUMAN PRESCRIPTION DRUG LABEL 1 0023-0000 SOLUTION/ DROPS 1.20 mg OPHTHALMIC Export only 1 sections
Fresh Clear HUMAN PRESCRIPTION DRUG LABEL 1 0023-0000 SOLUTION/ DROPS 1.20 mg OPHTHALMIC Export only 1 sections
CHILDRENS DIMETAPP COLD AND COUGH HUMAN OTC DRUG LABEL 3 0031-2234 LIQUID 2.50 mg ORAL OTC monograph final 16 sections
CHILDRENS DIMETAPP COLD AND ALLERGY HUMAN OTC DRUG LABEL 2 0031-2235 LIQUID 2.50 mg ORAL OTC monograph final 16 sections
Childrens Dimetapp Multi-Symptom Cold and Flu HUMAN OTC DRUG LABEL 3 0031-2249 LIQUID 5 mg ORAL Unapproved drug other 17 sections
Childrens Robitussin Cough and Cold CF HUMAN OTC DRUG LABEL 3 0031-8716 LIQUID 2.50 mg ORAL OTC monograph final 17 sections
Childrens Robitussin Cough and Cold CF HUMAN OTC DRUG LABEL 3 0031-8716 LIQUID 2.50 mg ORAL OTC monograph final 17 sections
Childrens Robitussin Cough and Cold CF HUMAN OTC DRUG LABEL 3 0031-8716 LIQUID 2.50 mg ORAL OTC monograph final 17 sections
Robitussin Peak Cold Multi-Symptom Cold HUMAN OTC DRUG LABEL 3 0031-8742 LIQUID 5 mg ORAL OTC MONOGRAPH FINAL 17 sections
Robitussin Peak Cold Multi-Symptom Cold HUMAN OTC DRUG LABEL 3 0031-8742 LIQUID 5 mg ORAL OTC MONOGRAPH FINAL 17 sections
Robitussin Severe Multi-Symptom Cough Cold Flu HUMAN OTC DRUG LABEL 4 0031-8751 LIQUID 10 mg ORAL OTC monograph final 17 sections
Robitussin Severe Multi-Symptom Cough Cold Flu HUMAN OTC DRUG LABEL 4 0031-8751 LIQUID 10 mg ORAL OTC monograph final 17 sections
Robitussin Severe Multi-Symptom Cough Cold Flu Nighttime HUMAN OTC DRUG LABEL 3 0031-8752 SOLUTION 10 mg ORAL OTC monograph final 17 sections
Robitussin Severe Multi-Symptom Cough Cold Flu Nighttime HUMAN OTC DRUG LABEL 3 0031-8752 SOLUTION 10 mg ORAL OTC monograph final 17 sections
Robitussin Severe Multi-Symptom Cough Cold Flu Nighttime HUMAN OTC DRUG LABEL 3 0031-8752 SOLUTION 10 mg ORAL OTC monograph final 17 sections
Robitussin Direct Stuffy Nose HUMAN OTC DRUG LABEL 1 0031-9305 TABLET, COATED 10 mg ORAL OTC monograph final 16 sections
Cyclomydril HUMAN PRESCRIPTION DRUG LABEL 2 0065-0359 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 20 sections
Cyclomydril HUMAN PRESCRIPTION DRUG LABEL 2 0065-0359 SOLUTION/ DROPS 10 mg OPHTHALMIC ANDA 20 sections
TheraFlu Cold and Flu HUMAN OTC DRUG LABEL 3 0067-0924 POWDER 10 mg ORAL Export only 10 sections
4 WayFast Acting HUMAN OTC DRUG LABEL 1 0067-2086 SPRAY 10 mg NASAL OTC monograph final 14 sections
TherafluPowerPods Daytime Severe Cold HUMAN OTC DRUG LABEL 3 0067-6094 POWDER, FOR SOLUTION 10 mg ORAL OTC monograph final 16 sections
THERAFLUPOWERPODS NIGHTTIME SEVERE COLD HUMAN OTC DRUG LABEL 3 0067-6095 POWDER, FOR SOLUTION 10 mg ORAL OTC monograph final 16 sections
THERAFLUMULTI-SYMPTOM SEVERE COLD HUMAN OTC DRUG LABEL 3 0067-6426 POWDER, FOR SOLUTION 10 mg ORAL OTC monograph final 17 sections
Theraflu Severe Cold relief Nighttime HUMAN OTC DRUG LABEL 3 0067-6801 POWDER 10 mg ORAL OTC monograph final 17 sections
TherafluFlu and Sore Throat HUMAN OTC DRUG LABEL 3 0067-7916 POWDER, FOR SOLUTION 10 mg ORAL OTC monograph final 17 sections
TherafluDaytime Severe Cold and Cough HUMAN OTC DRUG LABEL 3 0067-7917 POWDER, FOR SOLUTION 10 mg ORAL OTC monograph final 16 sections
THERAFLUNIGHTTIME SEVERE COLD AND COUGH HUMAN OTC DRUG LABEL 3 0067-7918 POWDER, FOR SOLUTION 10 mg ORAL OTC monograph final 17 sections
THERAFLUSINUS AND PAIN HUMAN OTC DRUG LABEL 3 0067-7920 POWDER, FOR SOLUTION 10 mg ORAL OTC monograph final 17 sections
THERAFLUSINUS AND PAIN HUMAN OTC DRUG LABEL 3 0067-7920 POWDER, FOR SOLUTION 10 mg ORAL OTC monograph final 17 sections
TriaminicDay Time Cold and Cough HUMAN OTC DRUG LABEL 2 0067-8105 SYRUP 2.50 mg ORAL OTC monograph final 14 sections