phenobarbital ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
hypnotics, barbituric acid derivatives 2134 50-06-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • phenobarbitone
  • phenobarbital
  • adonal
  • dormiral
  • versomnal
  • neurobarb
  • phenaemal
  • sedophen
  • phenobarbital sodium
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
  • Molecular weight: 232.24
  • Formula: C12H12N2O3
  • CLOGP: 1.36
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 75.27
  • ALOGS: -2.93
  • ROTB: 2

Drug dosage:

DoseUnitRoute
0.10 g O
0.10 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 24 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 9.30 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.54 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.06 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.49 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 99 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1912 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 412.83 15.27 309 14118 117565 50473132
Status epilepticus 361.39 15.27 138 14289 13268 50577429
Multiple-drug resistance 321.32 15.27 90 14337 3224 50587473
Drug reaction with eosinophilia and systemic symptoms 314.25 15.27 156 14271 28268 50562429
Epilepsy 147.25 15.27 86 14341 21481 50569216
Toxicity to various agents 133.08 15.27 226 14201 212273 50378424
Drug interaction 127.22 15.27 214 14213 199407 50391290
Drug resistance 125.10 15.27 74 14353 18915 50571782
Drug ineffective 114.30 15.27 497 13930 818836 49771861
Generalised tonic-clonic seizure 91.75 15.27 69 14358 26241 50564456
Intra-abdominal pressure increased 89.72 15.27 19 14408 200 50590497
Hyperammonaemia 86.98 15.27 37 14390 4687 50586010
Ataxia 86.30 15.27 52 14375 13734 50576963
Coma 84.11 15.27 92 14335 56787 50533910
Pneumatosis 81.98 15.27 20 14407 411 50590286
Abortion spontaneous 80.66 15.27 78 14349 41694 50549003
Anticonvulsant drug level decreased 78.96 15.27 24 14403 1147 50589550
Angiofibroma 76.17 15.27 15 14412 106 50590591
Anticonvulsant drug level increased 75.01 15.27 24 14403 1360 50589337
Drug withdrawal convulsions 71.43 15.27 23 14404 1330 50589367
Infantile spasms 67.78 15.27 15 14412 197 50590500
Nystagmus 65.78 15.27 32 14395 5529 50585168
Necrosis ischaemic 65.29 15.27 19 14408 780 50589917
Haemophagocytic lymphohistiocytosis 63.08 15.27 36 14391 8597 50582100
Developmental glaucoma 59.61 15.27 11 14416 52 50590645
Hyperammonaemic encephalopathy 58.96 15.27 22 14405 1977 50588720
Breast hyperplasia 58.73 15.27 14 14413 260 50590437
Intestinal ischaemia 57.09 15.27 31 14396 6726 50583971
Oropharyngeal oedema 54.45 15.27 13 14414 243 50590454
Multiple organ dysfunction syndrome 53.81 15.27 69 14358 50268 50540429
Overdose 53.12 15.27 99 14328 99628 50491069
Cytomegalovirus hepatitis 51.69 15.27 13 14414 304 50590393
Angiomyolipoma 51.06 15.27 12 14415 209 50590488
Fatigue 49.20 15.27 79 14348 707522 49883175
Cerebellar atrophy 46.38 15.27 14 14413 653 50590044
Partial seizures 45.83 15.27 24 14403 4841 50585856
Myoclonic epilepsy 45.11 15.27 15 14412 960 50589737
Systemic inflammatory response syndrome 44.99 15.27 24 14403 5025 50585672
Mitral valve disease 44.15 15.27 18 14409 2048 50588649
Foetal anticonvulsant syndrome 44.09 15.27 13 14414 559 50590138
Lymphangioleiomyomatosis 43.58 15.27 10 14417 156 50590541
Abdominal discomfort 43.45 15.27 7 14420 231634 50359063
Arthralgia 43.28 15.27 37 14390 438665 50152032
Ultrasound ovary abnormal 43.19 15.27 9 14418 87 50590610
Drug ineffective for unapproved indication 41.55 15.27 40 14387 21241 50569456
Stillbirth 41.30 15.27 24 14403 5928 50584769
Necrotising colitis 40.99 15.27 12 14415 503 50590194
Unmasking of previously unidentified disease 40.15 15.27 13 14414 765 50589932
Foetal exposure during pregnancy 39.97 15.27 44 14383 27315 50563382
Laryngeal stenosis 39.84 15.27 13 14414 784 50589913
Hypotonia 39.18 15.27 26 14401 8108 50582589
Petit mal epilepsy 39.12 15.27 19 14408 3270 50587427
Joint swelling 38.70 15.27 11 14416 245275 50345422
Alopecia 38.65 15.27 11 14416 245036 50345661
Macroglossia 38.46 15.27 12 14415 626 50590071
Rheumatoid arthritis 38.25 15.27 6 14421 202544 50388153
Perforation 37.42 15.27 13 14414 951 50589746
Malabsorption 36.97 15.27 19 14408 3687 50587010
Product administered to patient of inappropriate age 36.82 15.27 17 14410 2613 50588084
Anticonvulsant drug level above therapeutic 36.67 15.27 11 14416 502 50590195
Systolic dysfunction 35.53 15.27 14 14413 1458 50589239
Metabolic acidosis 35.02 15.27 49 14378 38776 50551921
Atonic seizures 34.76 15.27 11 14416 601 50590096
Tachycardia 34.44 15.27 83 14344 99680 50491017
Stevens-Johnson syndrome 33.55 15.27 36 14391 21716 50568981
Altered state of consciousness 33.33 15.27 36 14391 21874 50568823
Urine delta aminolevulinate increased 32.35 15.27 5 14422 5 50590692
Electrocardiogram ST segment elevation 32.33 15.27 17 14410 3456 50587241
Exposure during pregnancy 30.90 15.27 90 14337 120925 50469772
Sopor 30.83 15.27 33 14394 19846 50570851
Seizure cluster 30.78 15.27 8 14419 214 50590483
Hepatitis 30.32 15.27 41 14386 31412 50559285
Ventricular hypokinesia 30.16 15.27 17 14410 3963 50586734
Maternal exposure during pregnancy 30.06 15.27 107 14320 159671 50431026
Electroencephalogram abnormal 29.41 15.27 16 14411 3483 50587214
Enterocolitis 29.26 15.27 20 14407 6547 50584150
Labelled drug-drug interaction medication error 29.01 15.27 24 14403 10453 50580244
Cardio-respiratory arrest 28.04 15.27 53 14374 53839 50536858
Necrotising enterocolitis neonatal 28.03 15.27 7 14420 159 50590538
Cognitive disorder 27.57 15.27 47 14380 44076 50546621
Electrocardiogram repolarisation abnormality 27.52 15.27 11 14416 1189 50589508
Eosinophilia 27.24 15.27 30 14397 18622 50572075
Focal dyscognitive seizures 27.23 15.27 14 14413 2718 50587979
Intentional overdose 27.15 15.27 57 14370 62447 50528250
Left ventricular hypertrophy 27.06 15.27 17 14410 4828 50585869
Anticonvulsant drug level below therapeutic 26.86 15.27 9 14418 590 50590107
Rhesus incompatibility 26.50 15.27 6 14421 88 50590609
Neonatal seizure 26.49 15.27 8 14419 374 50590323
Hypothermia 26.16 15.27 24 14403 11992 50578705
Porphyrins stool increased 26.10 15.27 5 14422 30 50590667
Pain 25.92 15.27 82 14345 578821 50011876
Hypotension 25.91 15.27 134 14293 235335 50355362
Calcinosis 25.83 15.27 12 14415 1870 50588827
Bradyphrenia 25.68 15.27 18 14409 6134 50584563
Nausea 25.64 15.27 109 14318 705289 49885408
Off label use 25.57 15.27 226 14201 474200 50116497
Intensive care unit acquired weakness 25.52 15.27 9 14418 688 50590009
Urine copper increased 25.41 15.27 4 14423 5 50590692
Arthropathy 25.04 15.27 7 14420 157899 50432798
Hypertonia 24.89 15.27 15 14412 3958 50586739
Systemic lupus erythematosus 24.72 15.27 5 14422 140617 50450080
Peripheral swelling 24.71 15.27 14 14413 205922 50384775
Sinusitis 24.50 15.27 9 14418 170549 50420148
Irritability 24.33 15.27 35 14392 28391 50562306
Acute hepatic failure 24.27 15.27 26 14401 15651 50575046
Swelling 23.61 15.27 14 14413 200858 50389839
Cardiotoxicity 23.53 15.27 18 14409 7009 50583688
Coma blister 23.51 15.27 6 14421 149 50590548
Atrioventricular block first degree 23.26 15.27 17 14410 6184 50584513
Electrocardiogram QRS complex prolonged 23.16 15.27 16 14411 5328 50585369
Eye movement disorder 23.04 15.27 15 14412 4530 50586167
Gingival hypertrophy 22.71 15.27 10 14417 1376 50589321
Diarrhoea 22.56 15.27 89 14338 588387 50002310
Euthyroid sick syndrome 22.36 15.27 5 14422 69 50590628
Cardiomegaly 22.18 15.27 25 14402 15920 50574777
Haemodynamic instability 21.43 15.27 18 14409 8006 50582691
Ovarian cancer stage III 21.32 15.27 6 14421 218 50590479
Suicide attempt 21.11 15.27 46 14381 51686 50539011
Pneumonia aspiration 20.67 15.27 34 14393 30970 50559727
Cachexia 20.66 15.27 14 14413 4519 50586178
Nasopharyngitis 20.57 15.27 15 14412 192912 50397785
Magnetic resonance imaging head abnormal 20.34 15.27 10 14417 1767 50588930
Developmental delay 20.12 15.27 9 14418 1285 50589412
Peritoneal perforation 19.72 15.27 5 14422 121 50590576
Febrile infection-related epilepsy syndrome 19.41 15.27 3 14424 3 50590694
Cross sensitivity reaction 19.37 15.27 10 14417 1959 50588738
Cardiac arrest 19.25 15.27 60 14367 83591 50507106
Respiratory acidosis 19.22 15.27 15 14412 6013 50584684
Impulsive behaviour 19.09 15.27 9 14418 1449 50589248
Ammonia increased 19.09 15.27 13 14414 4228 50586469
Intensive care unit delirium 18.98 15.27 4 14423 41 50590656
Myoclonus 18.96 15.27 22 14405 14448 50576249
Lactic acidosis 18.85 15.27 34 14393 33321 50557376
Back pain 18.81 15.27 21 14406 220009 50370688
Resuscitation 18.80 15.27 8 14419 1013 50589684
Drug level increased 18.39 15.27 25 14402 19243 50571454
Pain in extremity 18.35 15.27 31 14396 272834 50317863
Cerebral atrophy 18.13 15.27 13 14414 4588 50586109
Acquired macroglossia 18.06 15.27 5 14422 171 50590526
Crystalluria 18.06 15.27 6 14421 383 50590314
Urine amphetamine positive 17.90 15.27 4 14423 55 50590642
Hypoxic-ischaemic encephalopathy 17.83 15.27 12 14415 3830 50586867
Somnolence 17.58 15.27 89 14338 154896 50435801
Abscess 17.54 15.27 21 14406 14251 50576446
Intellectual disability 17.25 15.27 7 14420 787 50589910
Lip erosion 17.00 15.27 7 14420 817 50589880
Respiratory depression 16.99 15.27 19 14408 11991 50578706
Congenital megaureter 16.69 15.27 4 14423 76 50590621
Ventricular dysfunction 16.69 15.27 10 14417 2611 50588086
Pulmonary venous thrombosis 16.66 15.27 3 14424 12 50590685
Primitive reflex test positive 16.47 15.27 3 14424 13 50590684
Congenital eyelid malformation 16.47 15.27 3 14424 13 50590684
Rhabdomyolysis 16.26 15.27 35 14392 38992 50551705
Conjunctival hyperaemia 16.07 15.27 9 14418 2073 50588624
Cholestasis 15.79 15.27 27 14400 25374 50565323
Dyspnoea 15.61 15.27 92 14335 547516 50043181
Depressed level of consciousness 15.58 15.27 41 14386 51912 50538785
Headache 15.57 15.27 83 14344 506452 50084245
Sinus bradycardia 15.56 15.27 19 14408 13164 50577533
Sudden unexplained death in epilepsy 15.54 15.27 5 14422 288 50590409
Neurodegenerative disorder 15.51 15.27 5 14422 290 50590407
Fever neonatal 15.38 15.27 3 14424 20 50590677

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 426.37 17.77 329 11590 92794 29469814
Status epilepticus 309.87 17.77 128 11791 10666 29551942
Drug ineffective 299.42 17.77 526 11393 362644 29199964
Multiple-drug resistance 228.37 17.77 78 11841 3822 29558786
Hyperammonaemia 128.83 17.77 57 11862 5606 29557002
Drug reaction with eosinophilia and systemic symptoms 127.63 17.77 99 11820 27893 29534715
Epilepsy 124.99 17.77 83 11836 18349 29544259
Victim of child abuse 104.73 17.77 30 11889 815 29561793
Respiratory depression 101.72 17.77 65 11854 13458 29549150
Infantile spasms 97.10 17.77 21 11898 168 29562440
Drug resistance 78.74 17.77 67 11852 21473 29541135
Sedation 78.07 17.77 61 11858 17344 29545264
Toxicity to various agents 76.50 17.77 196 11723 173465 29389143
Anticonvulsant drug level above therapeutic 69.44 17.77 20 11899 554 29562054
Intellectual disability 67.55 17.77 23 11896 1114 29561494
Generalised tonic-clonic seizure 64.82 17.77 57 11862 19082 29543526
Autism spectrum disorder 61.31 17.77 25 11894 2007 29560601
Necrosis ischaemic 60.89 17.77 15 11904 223 29562385
Off label use 60.43 17.77 260 11659 300540 29262068
Drug dependence 56.53 17.77 55 11864 20926 29541682
Urine copper increased 55.12 17.77 9 11910 9 29562599
Anticonvulsant drug level increased 54.59 17.77 21 11898 1445 29561163
Epidural lipomatosis 52.71 17.77 17 11902 694 29561914
Product prescribing error 51.98 17.77 49 11870 17927 29544681
Nausea 51.91 17.77 26 11893 289229 29273379
Drug withdrawal convulsions 51.86 17.77 19 11900 1142 29561466
Intensive care unit acquired weakness 51.83 17.77 18 11901 925 29561683
Sudden unexplained death in epilepsy 51.22 17.77 15 11904 441 29562167
Petit mal epilepsy 51.17 17.77 24 11895 2698 29559910
Dyspnoea 50.70 17.77 35 11884 326697 29235911
Dysmorphism 49.17 17.77 24 11895 2947 29559661
Somnolence 48.65 17.77 113 11806 93842 29468766
Hyperammonaemic encephalopathy 48.39 17.77 21 11898 1969 29560639
Foetal anticonvulsant syndrome 48.13 17.77 18 11901 1146 29561462
Partial seizures 45.74 17.77 25 11894 3878 29558730
Coma 45.38 17.77 67 11852 39383 29523225
Intestinal ischaemia 45 17.77 30 11889 6662 29555946
Developmental delay 43.66 17.77 21 11898 2497 29560111
Anticonvulsant drug level decreased 43.02 17.77 16 11903 1003 29561605
Porphyrins stool increased 42.87 17.77 7 11912 7 29562601
Excessive eye blinking 42.73 17.77 13 11906 437 29562171
Gaze palsy 42.70 17.77 17 11902 1282 29561326
Superinfection 41.85 17.77 19 11900 1982 29560626
Hypotonia 41.79 17.77 29 11890 6873 29555735
Juvenile idiopathic arthritis 41.54 17.77 17 11902 1377 29561231
Mucosal ulceration 41.40 17.77 15 11904 873 29561735
Ataxia 40.88 17.77 36 11883 12067 29550541
Psychomotor retardation 40.33 17.77 21 11898 2955 29559653
Product use issue 38.48 17.77 72 11847 51372 29511236
Nystagmus 38.18 17.77 23 11896 4286 29558322
Cognitive disorder 36.23 17.77 46 11873 23453 29539155
Electroencephalogram abnormal 36.07 17.77 18 11901 2317 29560291
Ehlers-Danlos syndrome 35.19 17.77 7 11912 35 29562573
Benzodiazepine drug level decreased 35.19 17.77 7 11912 35 29562573
Hepatitis fulminant 34.09 17.77 20 11899 3551 29559057
Behaviour disorder 33.86 17.77 20 11899 3596 29559012
Drug abuse 33.83 17.77 89 11830 79794 29482814
Tonic convulsion 33.40 17.77 13 11906 923 29561685
Necrotising enterocolitis neonatal 33.05 17.77 9 11910 202 29562406
Fatigue 32.99 17.77 48 11871 316773 29245835
Language disorder 32.94 17.77 16 11903 1943 29560665
Foetal exposure during pregnancy 32.62 17.77 53 11866 33814 29528794
Hypertelorism 32.00 17.77 11 11908 548 29562060
Poor feeding infant 30.20 17.77 10 11909 444 29562164
Laryngomalacia 29.54 17.77 9 11910 304 29562304
Atonic seizures 29.36 17.77 8 11911 180 29562428
Systemic inflammatory response syndrome 29.07 17.77 22 11897 5959 29556649
Testicular atrophy 28.92 17.77 10 11909 507 29562101
Hepatic adenoma 28.32 17.77 6 11913 43 29562565
Sopor 28.21 17.77 28 11891 10906 29551702
Muscle mass 27.62 17.77 8 11911 226 29562382
Posture abnormal 27.13 17.77 14 11905 1933 29560675
Hyperchloraemia 26.87 17.77 9 11910 414 29562194
Drug monitoring procedure not performed 26.79 17.77 8 11911 252 29562356
Fanconi syndrome 26.72 17.77 13 11906 1585 29561023
Irritability 26.00 17.77 38 11881 22114 29540494
Hyperlipasaemia 25.63 17.77 9 11910 478 29562130
Blood lactic acid increased 25.39 17.77 20 11899 5746 29556862
Completed suicide 25.36 17.77 87 11832 90159 29472449
Strabismus 25.13 17.77 12 11907 1404 29561204
Pneumonia aspiration 24.50 17.77 49 11870 36688 29525920
Urine delta aminolevulinate increased 24.50 17.77 4 11915 4 29562604
Acute hepatic failure 24.38 17.77 27 11892 11925 29550683
Arthralgia 24.30 17.77 13 11906 139604 29423004
Posthaemorrhagic hydrocephalus 24.00 17.77 6 11913 95 29562513
Drug level decreased 23.98 17.77 20 11899 6227 29556381
Diarrhoea 23.71 17.77 63 11856 332635 29229973
Respiratory acidosis 23.46 17.77 17 11902 4311 29558297
Anticonvulsant drug level below therapeutic 23.40 17.77 9 11910 619 29561989
Overdose 23.34 17.77 78 11841 79741 29482867
Psychomotor skills impaired 23.05 17.77 14 11905 2647 29559961
Dizziness 22.51 17.77 26 11893 189658 29372950
Drug withdrawal syndrome neonatal 22.29 17.77 15 11904 3380 29559228
Malaise 22.24 17.77 19 11900 159583 29403025
Therapeutic product effect incomplete 22.22 17.77 49 11870 39256 29523352
Drug ineffective for unapproved indication 22.18 17.77 28 11891 14186 29548422
Pain 22.01 17.77 22 11897 171410 29391198
Purple glove syndrome 21.36 17.77 5 11914 59 29562549
Drug interaction 21.18 17.77 144 11775 197241 29365367
Abdominal wall haematoma 20.68 17.77 11 11908 1616 29560992
Growth retardation 20.62 17.77 11 11908 1625 29560983
Product administered to patient of inappropriate age 20.54 17.77 13 11906 2642 29559966
Abnormal labour affecting foetus 20.46 17.77 4 11915 18 29562590
Pelvic deformity 20.28 17.77 4 11915 19 29562589
Haematuria traumatic 20.28 17.77 6 11913 183 29562425
Chest pain 20.11 17.77 10 11909 111963 29450645
Talipes 19.68 17.77 11 11908 1781 29560827
Condition aggravated 19.59 17.77 113 11806 146182 29416426
Social avoidant behaviour 19.32 17.77 13 11906 2929 29559679
Child abuse 19.09 17.77 6 11913 225 29562383
Pancytopenia 19.04 17.77 5 11914 83163 29479445
Abdominal pain 18.99 17.77 16 11903 135341 29427267
Myoclonus 18.86 17.77 25 11894 13284 29549324
Malabsorption 18.83 17.77 11 11908 1937 29560671
Myocardial fibrosis 18.80 17.77 9 11910 1059 29561549
Partial seizures with secondary generalisation 18.51 17.77 6 11913 249 29562359
Pain in extremity 18.18 17.77 11 11908 110422 29452186
Rash maculo-papular 18.15 17.77 34 11885 24255 29538353
Propofol infusion syndrome 17.95 17.77 8 11911 799 29561809
Stress cardiomyopathy 17.92 17.77 10 11909 1614 29560994

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 574.81 14.19 465 21406 166427 64310434
Status epilepticus 563.69 14.19 228 21643 21435 64455426
Multiple-drug resistance 427.21 14.19 136 21735 6366 64470495
Drug reaction with eosinophilia and systemic symptoms 414.26 14.19 247 21624 53970 64422891
Drug ineffective 284.91 14.19 769 21102 839478 63637383
Epilepsy 223.24 14.19 140 21731 33391 64443470
Hyperammonaemia 206.20 14.19 89 21782 9815 64467046
Toxicity to various agents 173.74 14.19 381 21490 363132 64113729
Generalised tonic-clonic seizure 140.71 14.19 113 21758 39744 64437117
Necrosis ischaemic 123.61 14.19 34 21837 949 64475912
Drug resistance 122.79 14.19 99 21772 35003 64441858
Ataxia 121.87 14.19 82 21789 22002 64454859
Intestinal ischaemia 118.80 14.19 64 21807 11485 64465376
Coma 118.07 14.19 147 21724 87468 64389393
Drug interaction 118.05 14.19 328 21543 361755 64115106
Anticonvulsant drug level decreased 114.91 14.19 37 21834 1793 64475068
Drug withdrawal convulsions 109.43 14.19 37 21834 2091 64474770
Anticonvulsant drug level increased 109.26 14.19 38 21833 2339 64474522
Victim of child abuse 108.94 14.19 30 21841 841 64476020
Anticonvulsant drug level above therapeutic 99.53 14.19 29 21842 1001 64475860
Infantile spasms 97.67 14.19 22 21849 261 64476600
Respiratory depression 96.91 14.19 73 21798 23370 64453491
Hyperammonaemic encephalopathy 96.20 14.19 40 21831 4018 64472843
Nystagmus 95.36 14.19 51 21820 9017 64467844
Partial seizures 90.90 14.19 46 21825 7261 64469600
Intra-abdominal pressure increased 84.15 14.19 19 21852 228 64476633
Urine copper increased 81.37 14.19 13 21858 14 64476847
Intensive care unit acquired weakness 77.04 14.19 27 21844 1700 64475161
Systemic inflammatory response syndrome 76.39 14.19 46 21825 10189 64466672
Pneumatosis 74.56 14.19 22 21849 794 64476067
Angiofibroma 72.15 14.19 15 21856 118 64476743
Drug dependence 69.06 14.19 70 21801 33242 64443619
Overdose 68.93 14.19 161 21710 159405 64317456
Nausea 68.11 14.19 101 21770 785699 63691162
Porphyrins stool increased 67.01 14.19 12 21859 37 64476824
Breast hyperplasia 66.17 14.19 14 21857 121 64476740
Petit mal epilepsy 63.53 14.19 32 21839 5000 64471861
Electroencephalogram abnormal 62.52 14.19 32 21839 5171 64471690
Fatigue 61.26 14.19 100 21771 748630 63728231
Atonic seizures 61.07 14.19 18 21853 647 64476214
Off label use 58.30 14.19 390 21481 632416 63844445
Arthralgia 57.38 14.19 40 21831 442220 64034641
Product prescribing error 57.06 14.19 65 21806 35204 64441657
Urine delta aminolevulinate increased 56.67 14.19 9 21862 9 64476852
Cerebellar atrophy 56.61 14.19 19 21852 1049 64475812
Malabsorption 55.59 14.19 28 21843 4375 64472486
Sopor 55.50 14.19 59 21812 29602 64447259
Drug abuse 55.44 14.19 132 21739 132242 64344619
Dyspnoea 54.21 14.19 101 21770 718573 63758288
Anticonvulsant drug level below therapeutic 53.42 14.19 18 21853 1006 64475855
Sudden unexplained death in epilepsy 53.40 14.19 16 21855 609 64476252
Oropharyngeal oedema 52.26 14.19 13 21858 242 64476619
Epidural lipomatosis 52.09 14.19 17 21854 860 64476001
Drug ineffective for unapproved indication 51.42 14.19 58 21813 31075 64445786
Acute hepatic failure 50.74 14.19 53 21818 26059 64450802
Stevens-Johnson syndrome 50.20 14.19 60 21811 34189 64442672
Angiomyolipoma 50.06 14.19 12 21859 190 64476671
Pneumonia aspiration 49.31 14.19 79 21792 59192 64417669
Somnolence 48.87 14.19 166 21705 203479 64273382
Multiple organ dysfunction syndrome 46.71 14.19 105 21766 101308 64375553
Cognitive disorder 45.25 14.19 73 21798 55014 64421847
Lymphangioleiomyomatosis 42.93 14.19 10 21861 139 64476722
Intellectual disability 42.04 14.19 15 21856 995 64475866
Myoclonic epilepsy 42.03 14.19 17 21854 1591 64475270
Ultrasound ovary abnormal 41.63 14.19 9 21862 87 64476774
Cytomegalovirus hepatitis 41.10 14.19 13 21858 594 64476267
Mitral valve disease 39.96 14.19 19 21852 2619 64474242
Joint swelling 39.45 14.19 12 21859 215370 64261491
Respiratory acidosis 39.20 14.19 30 21841 9825 64467036
Irritability 39.17 14.19 55 21816 36691 64440170
Infusion related reaction 38.77 14.19 5 21866 164462 64312399
Rheumatoid arthritis 38.72 14.19 5 21866 164289 64312572
Hypotonia 37.87 14.19 31 21840 11181 64465680
Blood lactic acid increased 37.77 14.19 30 21841 10371 64466490
Laryngeal stenosis 37.47 14.19 13 21858 794 64476067
Metabolic acidosis 36.69 14.19 77 21794 70881 64405980
Completed suicide 36.67 14.19 162 21709 224252 64252609
Haemophagocytic lymphohistiocytosis 36.48 14.19 37 21834 17572 64459289
Hepatic adenoma 36.42 14.19 10 21861 277 64476584
Pain 36.40 14.19 84 21787 553427 63923434
Benzodiazepine drug level decreased 36.40 14.19 7 21864 35 64476826
Altered state of consciousness 34.98 14.19 53 21818 37849 64439012
Gaze palsy 34.51 14.19 17 21854 2533 64474328
Peripheral swelling 34.28 14.19 14 21857 209139 64267722
Mucosal ulceration 34.24 14.19 15 21856 1712 64475149
Ammonia increased 33.98 14.19 24 21847 6953 64469908
Macroglossia 33.87 14.19 13 21858 1059 64475802
Cardiotoxicity 33.85 14.19 28 21843 10246 64466615
Abdominal discomfort 33.67 14.19 10 21861 182312 64294549
Eosinophilia 33.39 14.19 52 21819 38024 64438837
Gingival hypertrophy 33.31 14.19 17 21854 2730 64474131
Superinfection 33.03 14.19 19 21852 3867 64472994
Perforation 33.00 14.19 13 21858 1135 64475726
Propofol infusion syndrome 31.91 14.19 14 21857 1603 64475258
Hepatitis fulminant 31.53 14.19 22 21849 6252 64470609
Left ventricular hypertrophy 31.51 14.19 26 21845 9480 64467381
Pain in extremity 31.27 14.19 34 21837 303051 64173810
Hypothermia 31.11 14.19 36 21835 19820 64457041
Drug level decreased 31.10 14.19 28 21843 11475 64465386
Diarrhoea 31.07 14.19 133 21738 722571 63754290
Cardio-respiratory arrest 30.78 14.19 88 21783 98305 64378556
Back pain 30.61 14.19 24 21847 250147 64226714
Myoclonus 30.41 14.19 40 21831 25078 64451783
Testicular atrophy 30.28 14.19 9 21862 333 64476528
Headache 28.98 14.19 88 21783 529379 63947482
Alopecia 28.97 14.19 10 21861 165680 64311181
Fanconi syndrome 28.95 14.19 15 21856 2486 64474375
Unmasking of previously unidentified disease 28.48 14.19 13 21858 1634 64475227
Excessive eye blinking 28.45 14.19 12 21859 1248 64475613
Ehlers-Danlos syndrome 28.00 14.19 7 21864 133 64476728
Hyperchloraemia 27.84 14.19 11 21860 968 64475893
Juvenile idiopathic arthritis 27.83 14.19 17 21854 3862 64472999
Rhesus incompatibility 27.78 14.19 5 21866 16 64476845
Malaise 27.77 14.19 58 21813 396189 64080672
Suicide attempt 27.77 14.19 69 21802 70938 64405923
Product administered to patient of inappropriate age 27.59 14.19 18 21853 4583 64472278
Cross sensitivity reaction 27.39 14.19 16 21855 3351 64473510
Tonic convulsion 26.83 14.19 13 21858 1868 64474993
Intentional overdose 26.74 14.19 79 21792 89865 64386996
Blood pressure increased 26.00 14.19 13 21858 172539 64304322
Cardiac arrest 25.74 14.19 112 21759 153952 64322909
Seizure cluster 25.50 14.19 8 21863 356 64476505
Hepatitis 25.37 14.19 51 21820 45531 64431330
Ventricular hypokinesia 25.24 14.19 21 21850 7748 64469113
Blood zinc increased 25.19 14.19 4 21867 4 64476857
Hypertonia 24.60 14.19 19 21852 6306 64470555
Muscle mass 24.50 14.19 8 21863 405 64476456
Tachycardia 24.42 14.19 108 21763 149471 64327390
Cerebral atrophy 24.31 14.19 20 21851 7265 64469596
Febrile infection-related epilepsy syndrome 23.87 14.19 5 21866 41 64476820
Paraesthesia 23.72 14.19 8 21863 134514 64342347
Choreoathetosis 23.70 14.19 11 21860 1436 64475425
Calcinosis 23.23 14.19 12 21859 1976 64474885
Coagulopathy 23.13 14.19 40 21831 31880 64444981
Malignant neoplasm progression 23.12 14.19 5 21866 112866 64363995
Poor feeding infant 22.96 14.19 6 21865 137 64476724
Systolic dysfunction 22.88 14.19 14 21857 3188 64473673
Anaemia 22.86 14.19 60 21811 378620 64098241
Eye movement disorder 22.71 14.19 19 21852 7060 64469801
Focal dyscognitive seizures 22.54 14.19 14 21857 3276 64473585
Euthyroid sick syndrome 22.22 14.19 5 21866 59 64476802
Stomatitis 22.16 14.19 5 21866 109600 64367261
Posture abnormal 22.09 14.19 14 21857 3392 64473469
Therapeutic product effect decreased 21.89 14.19 6 21865 115345 64361516
Ovarian cancer stage III 21.72 14.19 6 21865 170 64476691
Febrile neutropenia 21.71 14.19 19 21852 187638 64289223
Chest pain 21.65 14.19 29 21842 235951 64240910
Abdominal pain 21.64 14.19 46 21825 312329 64164532
Haematuria traumatic 21.27 14.19 6 21865 184 64476677
Intentional product misuse 21.01 14.19 63 21808 72232 64404629
Electrocardiogram repolarisation abnormality 20.96 14.19 11 21860 1871 64474990
Behaviour disorder 20.93 14.19 15 21856 4447 64472414
Hyperlipasaemia 20.76 14.19 9 21862 1001 64475860
Product use issue 20.71 14.19 104 21767 151611 64325250
Developmental delay 20.54 14.19 9 21862 1028 64475833
Hyponatraemia 20.47 14.19 102 21769 148237 64328624
Acidosis hyperchloraemic 20.47 14.19 8 21863 684 64476177
Rhabdomyolysis 20.42 14.19 73 21798 91653 64385208
Child abuse 20.40 14.19 6 21865 214 64476647
Electrocardiogram ST segment elevation 20.28 14.19 18 21853 7241 64469620
Selective eating disorder 20.27 14.19 6 21865 219 64476642
Dermatitis exfoliative 20.08 14.19 21 21850 10331 64466530
Swelling 20.06 14.19 15 21856 160203 64316658
Neurodegenerative disorder 20.06 14.19 7 21864 435 64476426
Haemodynamic instability 20.02 14.19 25 21846 14887 64461974
Hyperplasia 19.99 14.19 9 21862 1095 64475766
Coma blister 19.98 14.19 6 21865 230 64476631
Foetal anticonvulsant syndrome 19.98 14.19 6 21865 230 64476631
Arthropathy 19.97 14.19 8 21863 120959 64355902
Depressed level of consciousness 19.16 14.19 66 21805 81370 64395491
Drug monitoring procedure not performed 19.14 14.19 8 21863 814 64476047
Nasopharyngitis 19.12 14.19 23 21848 196050 64280811
Injection site pain 19.00 14.19 7 21864 111401 64365460
Atrial fibrillation 18.99 14.19 18 21853 171071 64305790
Dysmorphism 18.69 14.19 7 21864 533 64476328
Asthma 17.98 14.19 5 21866 95220 64381641
Intensive care unit delirium 17.87 14.19 4 21867 46 64476815
Sinusitis 17.84 14.19 14 21857 145914 64330947
Labelled drug-drug interaction medication error 17.78 14.19 29 21842 22033 64454828
Withdrawal syndrome 17.76 14.19 30 21841 23462 64453399
Hepatic function abnormal 17.71 14.19 55 21816 64258 64412603
Drug level increased 17.54 14.19 37 21834 34159 64442702
Impulsive behaviour 17.41 14.19 11 21860 2652 64474209
Idiopathic generalised epilepsy 17.35 14.19 4 21867 53 64476808
Peritoneal perforation 17.20 14.19 5 21866 171 64476690
Microcephaly 17.04 14.19 5 21866 177 64476684
Myocardial fibrosis 16.93 14.19 9 21862 1571 64475290
Electrocardiogram QRS complex prolonged 16.60 14.19 18 21853 9226 64467635
Inhibitory drug interaction 16.57 14.19 12 21859 3615 64473246
Toxic epidermal necrolysis 16.56 14.19 38 21833 37128 64439733
Brain oedema 16.43 14.19 28 21843 22047 64454814
Hypotension 16.28 14.19 199 21672 380775 64096086
Acquired macroglossia 16.26 14.19 5 21866 208 64476653
Inappropriate antidiuretic hormone secretion 16.24 14.19 28 21843 22261 64454600
Hypoaesthesia 16.19 14.19 14 21857 139094 64337767
No adverse event 15.94 14.19 32 21839 28529 64448332
Urine amphetamine positive 15.90 14.19 4 21867 78 64476783
Enterocolitis 15.90 14.19 20 21851 11998 64464863
Conjunctival hyperaemia 15.79 14.19 12 21859 3887 64472974
Salivary hypersecretion 15.77 14.19 20 21851 12093 64464768
Lip erosion 15.75 14.19 8 21863 1271 64475590
Chills 15.75 14.19 14 21857 137250 64339611
Discomfort 15.74 14.19 4 21867 80874 64395987
Unresponsive to stimuli 15.68 14.19 45 21826 50348 64426513
Partial seizures with secondary generalisation 15.66 14.19 6 21865 486 64476375
Dyspnoea exertional 15.65 14.19 3 21868 73727 64403134
Rash maculo-papular 15.62 14.19 43 21828 46983 64429878
Fever neonatal 15.60 14.19 3 21868 15 64476846
Pancreatitis 15.52 14.19 50 21821 59557 64417304
Carbohydrate antigen 125 increased 15.26 14.19 9 21862 1919 64474942
Abortion spontaneous 15.04 14.19 29 21842 25114 64451747
Incision site pain 14.98 14.19 10 21861 2644 64474217
Systemic lupus erythematosus 14.79 14.19 4 21867 77608 64399253
Hepatic encephalopathy 14.74 14.19 26 21845 21040 64455821
Resuscitation 14.74 14.19 9 21862 2042 64474819
Cough 14.58 14.19 53 21818 302095 64174766
Enzyme induction 14.56 14.19 4 21867 111 64476750
Drug level below therapeutic 14.36 14.19 15 21856 7369 64469492
Foetal exposure during pregnancy 14.33 14.19 12 21859 4464 64472397
Cellulitis 14.19 14.19 7 21864 93650 64383211

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 121.84 25.33 58 223 859 83538
Off label use 34.65 25.33 21 260 479 83918

Pharmacologic Action:

SourceCodeDescription
ATC N03AA02 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Barbiturates and derivatives
MeSH PA D000927 Anticonvulsants
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D065695 Cytochrome P-450 CYP2B6 Inducers
MeSH PA D065701 Cytochrome P-450 CYP3A Inducers
MeSH PA D018691 Excitatory Amino Acid Antagonists
MeSH PA D018682 GABA Agents
MeSH PA D018757 GABA Modulators
MeSH PA D006993 Hypnotics and Sedatives
MeSH PA D065606 Metabolic Side Effects of Drugs and Substances
MeSH PA D018377 Neurotransmitter Agents
CHEBI has role CHEBI:35623 anticonvulsants
CHEBI has role CHEBI:35717 hypnotics
CHEBI has role CHEBI:60798 EAA receptor antagonists
CHEBI has role CHEBI:88188 allergenic drug

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Migraine indication 37796009 DOID:6364
Tonic-clonic seizure indication 54200006
Epilepsy indication 84757009 DOID:1826
Bipolar disorder in remission indication 85248005
Vascular headache indication 128187005
Cluster headache syndrome indication 193031009
Lennox-Gastaut syndrome indication 230418006
Tonic-clonic epilepsy indication 352818000 DOID:7725
Epilepsy characterized by intractable complex partial seizures indication 442481002
Simple partial seizure indication 117891000119100
Cluster Headache Prevention indication
Hyperbilirubinemia off-label use 14783006 DOID:2741
Postmenopausal osteoporosis off-label use 102447009
Seizure disorder off-label use 128613002
Alcohol withdrawal syndrome off-label use 191480000
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Status epilepticus off-label use 230456007 DOID:1824
Neuropathic pain off-label use 247398009
Rapid Cycling Bipolar Affective Disorder off-label use
Brain damage contraindication 2470005
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Goiter contraindication 3716002 DOID:12176
Gastritis contraindication 4556007 DOID:4029
Osteomalacia contraindication 4598005 DOID:10573
Tachyarrhythmia contraindication 6285003
Suicidal thoughts contraindication 6471006
Urinary tract obstruction contraindication 7163005 DOID:5200
Alcoholism contraindication 7200002
Hyperammonemia contraindication 9360008
Peptic ulcer contraindication 13200003 DOID:750
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Hepatic encephalopathy contraindication 13920009 DOID:13413
Hyperkalemia contraindication 14140009
Disorder of thyroid gland contraindication 14304000 DOID:50
Severe chronic ulcerative colitis contraindication 14311001
Disorder of autonomic nervous system contraindication 15241006
Agranulocytosis contraindication 17182001 DOID:12987
Pulmonary edema contraindication 19242006 DOID:11396
Hashimoto thyroiditis contraindication 21983002
Myocardial infarction contraindication 22298006 DOID:5844
Glaucoma contraindication 23986001 DOID:1686
Acute tuberculosis contraindication 25629007
Alcohol intoxication contraindication 25702006
Shock contraindication 27942005
Toxic megacolon contraindication 28536002 DOID:1770
Atony of colon contraindication 29479008
Lymphadenopathy contraindication 30746006
Sarcoidosis contraindication 31541009 DOID:11335
Bronchitis contraindication 32398004 DOID:6132
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Depressive disorder contraindication 35489007
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Hypovolemic shock contraindication 39419009
Gastrointestinal ulcer contraindication 40845000
Hypothyroidism contraindication 40930008 DOID:1459
Complete trisomy 21 syndrome contraindication 41040004 DOID:14250
Third trimester pregnancy contraindication 41587001
Hyperactive behavior contraindication 44548000
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Achalasia of esophagus contraindication 45564002 DOID:9164
Chronic heart failure contraindication 48447003
Retroperitoneal fibrosis contraindication 49120005
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Fibrosis of lung contraindication 51615001 DOID:3770
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Megaloblastic anemia contraindication 53165003 DOID:13382
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Paralytic ileus contraindication 55525008 DOID:8442
Heart disease contraindication 56265001 DOID:114
Peptic reflux disease contraindication 57643001
Multiple organ failure contraindication 57653000
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Diarrhea contraindication 62315008
Thrombophlebitis contraindication 64156001 DOID:3875
Ulcerative colitis contraindication 64766004 DOID:8577
Poisoning by phenobarbital contraindication 64921004
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Psychotic disorder contraindication 69322001
Poisoning by acetaminophen contraindication 70273001
Agoraphobia contraindication 70691001 DOID:593
Incontinence of feces contraindication 72042002
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Sleep apnea contraindication 73430006 DOID:0050847
Factor II deficiency contraindication 73975000
Reye's syndrome contraindication 74351001 DOID:14525
Appendicitis contraindication 74400008 DOID:8337
Gastrointestinal hemorrhage contraindication 74474003
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Spastic paralysis contraindication 78403003
Disturbance of salivary secretion contraindication 78948009
Hyperglycemia contraindication 80394007 DOID:4195
Cor pulmonale contraindication 83291003 DOID:8515
Hiatal hernia contraindication 84089009 DOID:12642
Leukopenia contraindication 84828003 DOID:615
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Hemophilia contraindication 90935002
Myasthenia gravis contraindication 91637004 DOID:437
Kidney stone contraindication 95570007
Dermatitis herpetiformis contraindication 111196000 DOID:8505
Anemia due to enzyme deficiency contraindication 111577008
Gastrointestinal obstruction contraindication 126765001
Pancytopenia contraindication 127034005 DOID:12450
von Willebrand disorder contraindication 128105004 DOID:12531
Autonomic dysreflexia contraindication 129618003
Bleeding contraindication 131148009
Cystic fibrosis contraindication 190905008 DOID:1485
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Angina pectoris contraindication 194828000
Impaired renal function disorder contraindication 197663003
Osteolysis contraindication 203522001
Non-infective meningitis contraindication 230155003
Myocardial dysfunction contraindication 233928007
Peripheral ischemia contraindication 233958001
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Bladder outflow obstruction contraindication 236645006
Sepsis syndrome contraindication 238150007
Hypocomplementemic urticarial vasculitis contraindication 239945009
Pyloric obstruction contraindication 244815007
Sleep automatism contraindication 247962006
Raynaud's phenomenon contraindication 266261006
Benign prostatic hyperplasia contraindication 266569009
Dyspnea contraindication 267036007
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Continuous fever contraindication 271751000
Drowsy contraindication 271782001
Cerebral ischemia contraindication 287731003
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Aplastic anemia contraindication 306058006 DOID:12449
Osteopenia contraindication 312894000
Panic disorder contraindication 371631005 DOID:594
Smoking cessation assistance contraindication 384742004
Angle-closure glaucoma contraindication 392291006 DOID:13550
Gastric ulcer contraindication 397825006 DOID:10808
Peripheral vascular disease contraindication 400047006
Respiratory insufficiency contraindication 409623005
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Chronic myocardial ischemia contraindication 413844008 DOID:3393
Disorder of coronary artery contraindication 414024009
Myocardial ischemia contraindication 414795007 DOID:3393
Granulocytopenic disorder contraindication 417672002
Myocardial infarction in recovery phase contraindication 418044006
Porphyria contraindication 418470004
Fever greater than 100.4 Fahrenheit contraindication 426000000
Hyperplasia of gingiva contraindication 441798003
Fibrosis of pleura contraindication 442110002
Acute erosive gastritis contraindication 444926003
Smokes tobacco daily contraindication 449868002
Acute exacerbation of asthma contraindication 708038006
Ergot Alkaloid Toxicity contraindication
Severe Pruritus contraindication
HLA-B 1502 Positive Status contraindication
Theophylline Toxicity contraindication
Severe Hypoxemia contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.56 acidic
pKa2 9.25 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Nuclear receptor subfamily 1 group I member 3 Nuclear hormone receptor WOMBAT-PK
Nuclear receptor subfamily 1 group I member 2 Nuclear hormone receptor WOMBAT-PK
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel WOMBAT-PK
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 5.60 CHEMBL

External reference:

IDSource
4017422 VUID
N0000145810 NUI
D00506 KEGG_DRUG
57-30-7 SECONDARY_CAS_RN
4017422 VANDF
4017423 VANDF
C0031412 UMLSCUI
CHEBI:8069 CHEBI
UQA PDB_CHEM_ID
CHEMBL40 ChEMBL_ID
DB01174 DRUGBANK_ID
CHEMBL149972 ChEMBL_ID
D010634 MESH_DESCRIPTOR_UI
4763 PUBCHEM_CID
414 INN_ID
2804 IUPHAR_LIGAND_ID
YQE403BP4D UNII
8134 RXNORM
2390 MMSL
4349 MMSL
5272 MMSL
5273 MMSL
d00340 MMSL
001406 NDDF
001407 NDDF
373505007 SNOMEDCT_US
51073002 SNOMEDCT_US
76898000 SNOMEDCT_US
4172 INN_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0121-0531 SOLUTION 20 mg ORAL unapproved drug other 29 sections
Phenobarbital Oral Solution HUMAN PRESCRIPTION DRUG LABEL 1 0121-0942 SOLUTION 20 mg ORAL unapproved drug other 14 sections
Phenobarbital Oral Solution HUMAN PRESCRIPTION DRUG LABEL 1 0121-1884 SOLUTION 30 mg ORAL unapproved drug other 14 sections
Phenobarbital Oral Solution HUMAN PRESCRIPTION DRUG LABEL 1 0121-2826 SOLUTION 60 mg ORAL unapproved drug other 14 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0143-1445 TABLET 15 mg ORAL UNAPPROVED DRUG OTHER 17 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0143-1450 TABLET 30 mg ORAL UNAPPROVED DRUG OTHER 17 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0143-1455 TABLET 60 mg ORAL UNAPPROVED DRUG OTHER 17 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0143-1458 TABLET 100 mg ORAL UNAPPROVED DRUG OTHER 17 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0143-1495 TABLET 15 mg ORAL UNAPPROVED DRUG OTHER 17 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0143-1500 TABLET 30 mg ORAL UNAPPROVED DRUG OTHER 17 sections
Belladonna Alkaloids with Phenobartbital HUMAN PRESCRIPTION DRUG LABEL 4 0440-7183 TABLET 16.20 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0463-6145 TABLET 30 mg ORAL UNAPPROVED DRUG OTHER 17 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0463-6151 TABLET 60 mg ORAL UNAPPROVED DRUG OTHER 17 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0463-6160 TABLET 15 mg ORAL UNAPPROVED DRUG OTHER 17 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0463-6170 TABLET 100 mg ORAL UNAPPROVED DRUG OTHER 17 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0603-1508 ELIXIR 20 mg ORAL UNAPPROVED DRUG OTHER 22 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0603-1508 ELIXIR 20 mg ORAL UNAPPROVED DRUG OTHER 22 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0603-5165 TABLET 16.20 mg ORAL UNAPPROVED DRUG OTHER 22 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0603-5166 TABLET 32.40 mg ORAL UNAPPROVED DRUG OTHER 22 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0603-5167 TABLET 64.80 mg ORAL UNAPPROVED DRUG OTHER 22 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0603-5168 TABLET 97.20 mg ORAL UNAPPROVED DRUG OTHER 22 sections
Phenobarbital Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0641-0476 INJECTION 65 mg INTRAMUSCULAR UNAPPROVED DRUG OTHER 19 sections
Phenobarbital Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0641-0476 INJECTION 65 mg INTRAMUSCULAR UNAPPROVED DRUG OTHER 19 sections
Phenobarbital Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0641-0477 INJECTION 130 mg INTRAMUSCULAR UNAPPROVED DRUG OTHER 19 sections
Phenobarbital Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0641-0477 INJECTION 130 mg INTRAMUSCULAR UNAPPROVED DRUG OTHER 19 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0904-6575 TABLET 32.40 mg ORAL Unapproved drug other 22 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 13517-107 ELIXIR 20 mg ORAL unapproved drug other 23 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 13517-110 TABLET 16.20 mg ORAL unapproved drug other 25 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 13517-111 TABLET 32.40 mg ORAL unapproved drug other 25 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 13517-112 TABLET 64.80 mg ORAL unapproved drug other 25 sections