phenobarbital Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
hypnotics, barbituric acid derivatives 2134 50-06-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • phenobarbitone
  • phenobarbital
  • adonal
  • dormiral
  • versomnal
  • neurobarb
  • phenaemal
  • sedophen
  • phenobarbital sodium
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
  • Molecular weight: 232.24
  • Formula: C12H12N2O3
  • CLOGP: 1.37
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 75.27
  • ALOGS: -2.93
  • ROTB: 2

Drug dosage:

DoseUnitRoute
0.10 g O
0.10 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 24 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 9.30 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.54 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.06 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.49 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 99 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1912 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 500.40 14.20 362 13848 122692 46549160
Status epilepticus 350.51 14.20 139 14071 13840 46658012
Drug reaction with eosinophilia and systemic symptoms 270.57 14.20 146 14064 29402 46642450
Epilepsy 244.79 14.20 127 14083 23611 46648241
Multiple-drug resistance 163.02 14.20 51 14159 2514 46669338
Toxicity to various agents 117.88 14.20 222 13988 211544 46460308
Drug interaction 99.70 14.20 202 14008 202892 46468960
Generalised tonic-clonic seizure 81.67 14.20 67 14143 27055 46644797
Drug ineffective 80.78 14.20 412 13798 677426 45994426
Ataxia 80.17 14.20 51 14159 13879 46657973
Intra-abdominal pressure increased 77.20 14.20 17 14193 203 46671649
Anticonvulsant drug level decreased 75.98 14.20 24 14186 1220 46670632
Angiofibroma 75.19 14.20 15 14195 106 46671746
Drug resistance 74.54 14.20 53 14157 17315 46654537
Coma 74.00 14.20 90 14120 58259 46613593
Pneumatosis 70.77 14.20 18 14192 412 46671440
Drug withdrawal convulsions 70.15 14.20 23 14187 1318 46670534
Nystagmus 68.94 14.20 34 14176 5665 46666187
Anticonvulsant drug level increased 68.86 14.20 23 14187 1397 46670455
Hyperammonaemia 65.72 14.20 31 14179 4685 46667167
Haemophagocytic lymphohistiocytosis 62.04 14.20 36 14174 8306 46663546
Developmental glaucoma 58.90 14.20 11 14199 52 46671800
Infantile spasms 58.39 14.20 14 14196 249 46671603
Breast hyperplasia 57.87 14.20 14 14196 259 46671593
Partial seizures 55.04 14.20 28 14182 4982 46666870
Necrosis ischaemic 54.52 14.20 17 14193 828 46671024
Hyperammonaemic encephalopathy 54.17 14.20 21 14189 1961 46669891
Angiomyolipoma 51.12 14.20 12 14198 194 46671658
Overdose 50.57 14.20 102 14108 101877 46569975
Cytomegalovirus hepatitis 50.48 14.20 13 14197 313 46671539
Intestinal ischaemia 49.16 14.20 29 14181 6896 46664956
Foetal anticonvulsant syndrome 46.16 14.20 13 14197 443 46671409
Cerebellar atrophy 46.03 14.20 14 14196 627 46671225
Rheumatoid arthritis 45.41 14.20 9 14201 240206 46431646
Lymphangioleiomyomatosis 42.24 14.20 10 14200 168 46671684
Myoclonic epilepsy 41.01 14.20 14 14196 909 46670943
Laryngeal stenosis 40.85 14.20 13 14197 677 46671175
Multiple organ dysfunction syndrome 40.20 14.20 63 14147 51647 46620205
Unmasking of previously unidentified disease 40.11 14.20 13 14197 718 46671134
Altered state of consciousness 39.77 14.20 42 14168 23306 46648546
Necrotising colitis 39.14 14.20 12 14198 552 46671300
Malabsorption 38.26 14.20 20 14190 3763 46668089
Seizure cluster 37.12 14.20 9 14201 168 46671684
Systemic inflammatory response syndrome 36.84 14.20 22 14188 5349 46666503
Anticonvulsant drug level above therapeutic 36.26 14.20 11 14199 488 46671364
Systolic dysfunction 36.18 14.20 14 14196 1300 46670552
Mitral valve disease 35.37 14.20 16 14194 2196 46669656
Product administered to patient of inappropriate age 35.36 14.20 17 14193 2679 46669173
Hypotonia 35.04 14.20 25 14185 8204 46663648
Fatigue 32.85 14.20 87 14123 608610 46063242
Petit mal epilepsy 32.50 14.20 17 14193 3203 46668649
Hypothermia 32.34 14.20 28 14182 12155 46659697
Ultrasound ovary abnormal 32.07 14.20 7 14203 80 46671772
Urine delta aminolevulinate increased 32.02 14.20 5 14205 5 46671847
Foetal exposure during pregnancy 30.45 14.20 42 14168 30705 46641147
Arthralgia 30.34 14.20 40 14170 364563 46307289
Electrocardiogram ST segment elevation 30.30 14.20 17 14193 3678 46668174
Atonic seizures 29.89 14.20 10 14200 610 46671242
Stevens-Johnson syndrome 29.61 14.20 36 14174 23261 46648591
Suicide attempt 29.61 14.20 57 14153 54979 46616873
Abortion spontaneous 29.60 14.20 50 14160 43596 46628256
Off label use 29.48 14.20 207 14003 379634 46292218
Enterocolitis 29.21 14.20 20 14190 6148 46665704
Perforation 28.91 14.20 11 14199 976 46670876
Drug ineffective for unapproved indication 28.80 14.20 30 14180 16383 46655469
Focal dyscognitive seizures 28.74 14.20 15 14195 2813 46669039
Intentional overdose 28.70 14.20 62 14148 64882 46606970
Labelled drug-drug interaction medication error 28.56 14.20 23 14187 9038 46662814
Hepatitis 27.50 14.20 41 14169 32174 46639678
Neonatal seizure 27.49 14.20 8 14202 307 46671545
Sopor 27.44 14.20 32 14178 19796 46652056
Tachycardia 27.05 14.20 79 14131 99543 46572309
Developmental delay 26.99 14.20 11 14199 1171 46670681
Necrotising enterocolitis neonatal 26.60 14.20 7 14203 184 46671668
Electrocardiogram repolarisation abnormality 26.27 14.20 11 14199 1254 46670598
Rhesus incompatibility 26.23 14.20 6 14204 86 46671766
Anticonvulsant drug level below therapeutic 26.21 14.20 9 14201 595 46671257
Ventricular hypokinesia 26.15 14.20 16 14194 4062 46667790
Calcinosis 25.79 14.20 12 14198 1757 46670095
Porphyrins stool increased 25.77 14.20 5 14205 30 46671822
Intensive care unit acquired weakness 25.68 14.20 9 14201 632 46671220
Urine copper increased 25.15 14.20 4 14206 5 46671847
Electroencephalogram abnormal 24.77 14.20 15 14195 3739 46668113
Cardio-respiratory arrest 24.03 14.20 55 14155 59814 46612038
Cachexia 23.77 14.20 16 14194 4783 46667069
Cardiotoxicity 23.20 14.20 18 14192 6704 46665148
Coma blister 23.12 14.20 6 14204 149 46671703
Maternal exposure during pregnancy 22.92 14.20 76 14134 102473 46569379
Joint swelling 22.83 14.20 11 14199 166062 46505790
Febrile infection-related epilepsy syndrome 22.61 14.20 4 14206 13 46671839
Abdominal discomfort 22.37 14.20 9 14201 151156 46520696
Atrioventricular block first degree 22.30 14.20 17 14193 6169 46665683
Euthyroid sick syndrome 22.17 14.20 5 14205 67 46671785
Ovarian cancer stage III 22.07 14.20 6 14204 179 46671673
Electrocardiogram QRS complex prolonged 21.93 14.20 16 14194 5433 46666419
Nausea 21.70 14.20 122 14088 687332 45984520
Pneumonia aspiration 21.15 14.20 36 14174 31569 46640283
Somnolence 21.15 14.20 99 14111 156422 46515430
Left ventricular hypertrophy 20.95 14.20 15 14195 4948 46666904
Alopecia 20.50 14.20 12 14198 162402 46509450
Irritability 19.41 14.20 33 14177 28913 46642939
Peritoneal perforation 19.24 14.20 5 14205 125 46671727
Hepatic function abnormal 18.94 14.20 36 14174 34385 46637467
Diarrhoea 18.91 14.20 97 14113 559505 46112347
Growth retardation 18.81 14.20 8 14202 947 46670905
Intensive care unit delirium 18.72 14.20 4 14206 41 46671811
Gingival hypertrophy 18.71 14.20 9 14201 1420 46670432
Infusion related reaction 18.67 14.20 4 14206 101204 46570648
Cholestasis 18.48 14.20 31 14179 26862 46644990
Drug hypersensitivity 18.34 14.20 132 14078 243693 46428159
Impulsive behaviour 18.21 14.20 9 14201 1506 46670346
Respiratory acidosis 18.10 14.20 15 14195 6133 46665719
Pulmonary venous thrombosis 18.00 14.20 3 14207 6 46671846
Musculoskeletal stiffness 17.81 14.20 4 14206 97989 46573863
Pain 17.65 14.20 80 14130 476868 46194984
Cyanosis 17.62 14.20 23 14187 15948 46655904
Acute hepatic failure 17.50 14.20 22 14188 14699 46657153
Back pain 17.48 14.20 23 14187 210016 46461836
White matter lesion 17.45 14.20 8 14202 1133 46670719
Stillbirth 17.39 14.20 15 14195 6476 46665376
Crystalluria 17.22 14.20 6 14204 414 46671438
Eosinophilia 17.18 14.20 25 14185 19192 46652660
Pain in extremity 17.11 14.20 33 14177 258647 46413205
Metabolic acidosis 17.10 14.20 37 14173 38743 46633109
Cerebral atrophy 17.09 14.20 13 14197 4703 46667149
Eye movement disorder 16.90 14.20 13 14197 4780 46667072
Lip erosion 16.76 14.20 7 14203 792 46671060
Drug level increased 16.50 14.20 24 14186 18417 46653435
Congenital eyelid malformation 16.47 14.20 3 14207 12 46671840
Myoclonus 16.35 14.20 21 14189 14331 46657521
Primitive reflex test positive 16.28 14.20 3 14207 13 46671839
Asthma 16.12 14.20 4 14206 91538 46580314
Congenital megaureter 16.05 14.20 4 14206 84 46671768
Cardiomegaly 16 14.20 23 14187 17459 46654393
Apparent life threatening event 15.92 14.20 4 14206 87 46671765
Bradyphrenia 15.89 14.20 14 14196 6216 46665636
Therapeutic product effect decreased 15.78 14.20 3 14207 82598 46589254
Ammonia increased 15.71 14.20 12 14198 4365 46667487
Lactic acidosis 15.70 14.20 33 14177 33876 46637976
Hypertonia 15.50 14.20 12 14198 4454 46667398
Dyspnoea 15.41 14.20 93 14117 515455 46156397
Ventricular dysfunction 15.38 14.20 10 14200 2822 46669030
Sudden unexplained death in epilepsy 15.29 14.20 5 14205 284 46671568
Prognathism 15.19 14.20 3 14207 20 46671832
Oropharyngeal oedema 14.72 14.20 4 14206 119 46671733
Neurodegenerative disorder 14.62 14.20 5 14205 326 46671526
Tonic convulsion 14.58 14.20 7 14203 1099 46670753
Peripheral swelling 14.53 14.20 16 14194 158055 46513797
Resuscitation 14.50 14.20 7 14203 1112 46670740
Sinusitis 14.47 14.20 11 14199 129757 46542095
Vanishing bile duct syndrome 14.46 14.20 6 14204 668 46671184
Hyperplasia 14.45 14.20 6 14204 669 46671183
Clumsiness 14.27 14.20 8 14202 1728 46670124
Hypoxic-ischaemic encephalopathy 14.26 14.20 11 14199 4062 46667790

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 631.47 15.61 410 10494 98065 29843509
Status epilepticus 291.88 15.61 120 10784 10952 29930622
Drug ineffective 201.04 15.61 404 10500 339983 29601591
Multiple-drug resistance 143.37 15.61 50 10854 2891 29938683
Drug reaction with eosinophilia and systemic symptoms 135.09 15.61 99 10805 28389 29913185
Epilepsy 125.90 15.61 83 10821 20086 29921488
Hyperammonaemia 116.05 15.61 51 10853 5469 29936105
Toxicity to various agents 97.46 15.61 205 10699 176978 29764596
Infantile spasms 89.64 15.61 21 10883 278 29941296
Sedation 82.34 15.61 59 10845 16314 29925260
Drug resistance 69.42 15.61 58 10846 20075 29921499
Sudden unexplained death in epilepsy 66.77 15.61 18 10886 432 29941142
Anticonvulsant drug level increased 63.38 15.61 23 10881 1492 29940082
Necrosis ischaemic 62.41 15.61 15 10889 223 29941351
Generalised tonic-clonic seizure 60.63 15.61 53 10851 19498 29922076
Somnolence 57.78 15.61 116 10788 96647 29844927
Urine copper increased 56.04 15.61 9 10895 9 29941565
Coma 53.99 15.61 70 10834 40379 29901195
Foetal anticonvulsant syndrome 52.99 15.61 17 10887 757 29940817
Hyperammonaemic encephalopathy 52.00 15.61 21 10883 1823 29939751
Anticonvulsant drug level decreased 48.41 15.61 17 10887 1002 29940572
Ataxia 47.97 15.61 37 10867 11425 29930149
Intellectual disability 47.67 15.61 16 10888 822 29940752
Superinfection 47.65 15.61 19 10885 1595 29939979
Intestinal ischaemia 46.96 15.61 30 10874 6867 29934707
Drug withdrawal convulsions 46.27 15.61 17 10887 1142 29940432
Nystagmus 45.65 15.61 25 10879 4313 29937261
Off label use 44.63 15.61 194 10710 249096 29692478
Nausea 43.95 15.61 27 10877 296930 29644644
Porphyrins stool increased 43.58 15.61 7 10897 7 29941567
Dysmorphism 43.56 15.61 19 10885 1998 29939576
Mucosal ulceration 43.06 15.61 15 10889 863 29940711
Respiratory depression 41.43 15.61 34 10870 11469 29930105
Intensive care unit acquired weakness 39.34 15.61 14 10890 858 29940716
Dyspnoea 38.38 15.61 39 10865 333256 29608318
Benzodiazepine drug level decreased 35.90 15.61 7 10897 35 29941539
Ehlers-Danlos syndrome 35.90 15.61 7 10897 35 29941539
Petit mal epilepsy 35.77 15.61 18 10886 2613 29938961
Victim of child abuse 35.62 15.61 10 10894 280 29941294
Partial seizures 34.99 15.61 20 10884 3747 29937827
Hypotonia 34.83 15.61 25 10879 6923 29934651
Electroencephalogram abnormal 34.52 15.61 17 10887 2357 29939217
Autism spectrum disorder 33.65 15.61 14 10890 1311 29940263
Cognitive disorder 33.17 15.61 42 10862 23648 29917926
Developmental delay 33.14 15.61 16 10888 2125 29939449
Fatigue 31.05 15.61 43 10861 320630 29620944
Sopor 30.51 15.61 28 10876 10963 29930611
Hepatic adenoma 29.71 15.61 6 10898 37 29941537
Testicular atrophy 29.68 15.61 10 10894 520 29941054
Hepatitis fulminant 28.98 15.61 18 10886 3923 29937651
Wrong schedule 28.53 15.61 7 10897 114 29941460
Completed suicide 28.27 15.61 90 10814 99402 29842172
Anticonvulsant drug level above therapeutic 28.24 15.61 9 10895 392 29941182
Drug monitoring procedure not performed 27.75 15.61 8 10896 247 29941327
Muscle mass 27.44 15.61 8 10896 257 29941317
Systemic inflammatory response syndrome 27.10 15.61 21 10883 6525 29935049
Blood lactic acid increased 27.00 15.61 20 10884 5810 29935764
Hyperchloraemia 26.99 15.61 9 10895 453 29941121
Acute hepatic failure 26.90 15.61 27 10877 11800 29929774
Drug interaction 26.72 15.61 143 10761 199425 29742149
Fanconi syndrome 26.67 15.61 13 10891 1762 29939812
Psychomotor retardation 25.83 15.61 14 10890 2365 29939209
Therapeutic product effect incomplete 25.67 15.61 45 10859 33789 29907785
Behaviour disorder 25.65 15.61 14 10890 2398 29939176
Tonic convulsion 25.04 15.61 10 10894 843 29940731
Urine delta aminolevulinate increased 24.90 15.61 4 10900 4 29941570
Irritability 24.85 15.61 36 10868 23014 29918560
Drug level decreased 24.85 15.61 19 10885 5786 29935788
Overdose 24.60 15.61 77 10827 84260 29857314
Child abuse 24.35 15.61 7 10897 214 29941360
Foetal exposure during pregnancy 24.13 15.61 46 10858 36825 29904749
Arthralgia 23.53 15.61 10 10894 135781 29805793
Wrong patient received product 23.45 15.61 12 10892 1805 29939769
Myocardial fibrosis 23.08 15.61 9 10895 712 29940862
Hyperlipasaemia 22.34 15.61 8 10896 499 29941075
Product administered to patient of inappropriate age 22.28 15.61 13 10891 2530 29939044
Rash maculo-papular 22.19 15.61 36 10868 25382 29916192
Purple glove syndrome 21.79 15.61 5 10899 60 29941514
Haematuria traumatic 21.54 15.61 6 10898 163 29941411
Atonic seizures 21.44 15.61 6 10898 166 29941408
Poor feeding infant 20.59 15.61 7 10897 374 29941200
Product use issue 20.39 15.61 49 10855 45967 29895607
Anticonvulsant drug level below therapeutic 20.38 15.61 8 10896 644 29940930
Suicide attempt 19.51 15.61 42 10862 36655 29904919
Stress cardiomyopathy 19.32 15.61 10 10894 1539 29940035
Growth retardation 19.02 15.61 10 10894 1590 29939984
Pain 18.91 15.61 21 10883 172620 29768954
Pancytopenia 18.81 15.61 4 10900 85048 29856526
Essential tremor 18.73 15.61 8 10896 799 29940775
Diarrhoea 18.70 15.61 61 10843 334042 29607532
Malaise 18.63 15.61 20 10884 166942 29774632
Diabetes insipidus 18.45 15.61 11 10893 2228 29939346
Ammonia increased 18.42 15.61 14 10890 4227 29937347
Acidosis hyperchloraemic 18.35 15.61 6 10898 284 29941290
Propofol infusion syndrome 18.19 15.61 8 10896 858 29940716
Lennox-Gastaut syndrome 18.01 15.61 4 10900 41 29941533
Drug ineffective for unapproved indication 18.00 15.61 21 10883 10859 29930715
Myoclonus 17.68 15.61 23 10881 13289 29928285
Choreoathetosis 17.54 15.61 8 10896 935 29940639
Depressed level of consciousness 17.26 15.61 41 10863 38181 29903393
Incision site pain 16.91 15.61 10 10894 1994 29939580
Pelvic deformity 16.86 15.61 3 10901 8 29941566
Chills 16.84 15.61 3 10901 72335 29869239
Rhesus incompatibility 16.60 15.61 3 10901 9 29941565
Pain in extremity 16.27 15.61 10 10894 110211 29831363
Dizziness 16.09 15.61 29 10875 194880 29746694
Extradural haematoma 15.77 15.61 8 10896 1181 29940393

Pharmacologic Action:

SourceCodeDescription
ATC N03AA02 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Barbiturates and derivatives
MeSH PA D000927 Anticonvulsants
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D065695 Cytochrome P-450 CYP2B6 Inducers
MeSH PA D065701 Cytochrome P-450 CYP3A Inducers
MeSH PA D018691 Excitatory Amino Acid Antagonists
MeSH PA D018682 GABA Agents
MeSH PA D018757 GABA Modulators
MeSH PA D006993 Hypnotics and Sedatives
MeSH PA D065606 Metabolic Side Effects of Drugs and Substances
MeSH PA D018377 Neurotransmitter Agents
CHEBI has role CHEBI:35623 antiepileptic
CHEBI has role CHEBI:35717 sedatives
CHEBI has role CHEBI:60798 excitatory amino acid receptor antagonists
CHEBI has role CHEBI:88188 allergenic drug

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Migraine indication 37796009 DOID:6364
Tonic-clonic seizure indication 54200006
Epilepsy indication 84757009 DOID:1826
Bipolar disorder in remission indication 85248005
Vascular headache indication 128187005
Cluster headache syndrome indication 193031009
Lennox-Gastaut syndrome indication 230418006
Tonic-clonic epilepsy indication 352818000 DOID:7725
Epilepsy characterized by intractable complex partial seizures indication 442481002
Simple partial seizure indication 117891000119100
Cluster Headache Prevention indication
Hyperbilirubinemia off-label use 14783006 DOID:2741
Postmenopausal osteoporosis off-label use 102447009
Seizure disorder off-label use 128613002
Alcohol withdrawal syndrome off-label use 191480000
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Status epilepticus off-label use 230456007 DOID:1824
Neuropathic pain off-label use 247398009
Rapid Cycling Bipolar Affective Disorder off-label use
Brain damage contraindication 2470005
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Goiter contraindication 3716002 DOID:12176
Gastritis contraindication 4556007 DOID:4029
Osteomalacia contraindication 4598005 DOID:10573
Tachyarrhythmia contraindication 6285003
Suicidal thoughts contraindication 6471006
Urinary tract obstruction contraindication 7163005 DOID:5200
Alcoholism contraindication 7200002
Hyperammonemia contraindication 9360008
Peptic ulcer contraindication 13200003 DOID:750
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Hepatic encephalopathy contraindication 13920009 DOID:13413
Hyperkalemia contraindication 14140009
Disorder of thyroid gland contraindication 14304000 DOID:50
Severe chronic ulcerative colitis contraindication 14311001
Disorder of autonomic nervous system contraindication 15241006
Agranulocytosis contraindication 17182001 DOID:12987
Pulmonary edema contraindication 19242006 DOID:11396
Hashimoto thyroiditis contraindication 21983002
Myocardial infarction contraindication 22298006 DOID:5844
Glaucoma contraindication 23986001 DOID:1686
Acute tuberculosis contraindication 25629007
Alcohol intoxication contraindication 25702006
Shock contraindication 27942005
Toxic megacolon contraindication 28536002 DOID:1770
Atony of colon contraindication 29479008
Lymphadenopathy contraindication 30746006
Sarcoidosis contraindication 31541009 DOID:11335
Bronchitis contraindication 32398004 DOID:6132
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Depressive disorder contraindication 35489007
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Hypovolemic shock contraindication 39419009
Gastrointestinal ulcer contraindication 40845000
Hypothyroidism contraindication 40930008 DOID:1459
Complete trisomy 21 syndrome contraindication 41040004 DOID:14250
Third trimester pregnancy contraindication 41587001
Hyperactive behavior contraindication 44548000
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Achalasia of esophagus contraindication 45564002 DOID:9164
Chronic heart failure contraindication 48447003
Retroperitoneal fibrosis contraindication 49120005
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Fibrosis of lung contraindication 51615001 DOID:3770
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Megaloblastic anemia contraindication 53165003 DOID:13382
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Paralytic ileus contraindication 55525008 DOID:8442
Heart disease contraindication 56265001 DOID:114
Peptic reflux disease contraindication 57643001
Multiple organ failure contraindication 57653000
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Diarrhea contraindication 62315008
Thrombophlebitis contraindication 64156001 DOID:3875
Ulcerative colitis contraindication 64766004 DOID:8577
Poisoning by phenobarbital contraindication 64921004
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Psychotic disorder contraindication 69322001
Poisoning by acetaminophen contraindication 70273001
Agoraphobia contraindication 70691001 DOID:593
Incontinence of feces contraindication 72042002
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Sleep apnea contraindication 73430006 DOID:0050847
Factor II deficiency contraindication 73975000
Reye's syndrome contraindication 74351001 DOID:14525
Appendicitis contraindication 74400008 DOID:8337
Gastrointestinal hemorrhage contraindication 74474003
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Spastic paralysis contraindication 78403003
Disturbance of salivary secretion contraindication 78948009
Hyperglycemia contraindication 80394007 DOID:4195
Cor pulmonale contraindication 83291003 DOID:8515
Hiatal hernia contraindication 84089009 DOID:12642
Leukopenia contraindication 84828003 DOID:615
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Hemophilia contraindication 90935002
Myasthenia gravis contraindication 91637004 DOID:437
Kidney stone contraindication 95570007
Dermatitis herpetiformis contraindication 111196000 DOID:8505
Anemia due to enzyme deficiency contraindication 111577008
Gastrointestinal obstruction contraindication 126765001
Pancytopenia contraindication 127034005 DOID:12450
von Willebrand disorder contraindication 128105004 DOID:12531
Autonomic dysreflexia contraindication 129618003
Bleeding contraindication 131148009
Cystic fibrosis contraindication 190905008 DOID:1485
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Angina pectoris contraindication 194828000
Impaired renal function disorder contraindication 197663003
Osteolysis contraindication 203522001
Non-infective meningitis contraindication 230155003
Myocardial dysfunction contraindication 233928007
Peripheral ischemia contraindication 233958001
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Bladder outflow obstruction contraindication 236645006
Sepsis syndrome contraindication 238150007
Hypocomplementemic urticarial vasculitis contraindication 239945009
Pyloric obstruction contraindication 244815007
Sleep automatism contraindication 247962006
Raynaud's phenomenon contraindication 266261006
Benign prostatic hyperplasia contraindication 266569009
Dyspnea contraindication 267036007
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Continuous fever contraindication 271751000
Drowsy contraindication 271782001
Cerebral ischemia contraindication 287731003
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Aplastic anemia contraindication 306058006 DOID:12449
Osteopenia contraindication 312894000
Panic disorder contraindication 371631005 DOID:594
Smoking cessation assistance contraindication 384742004
Angle-closure glaucoma contraindication 392291006 DOID:13550
Gastric ulcer contraindication 397825006 DOID:10808
Peripheral vascular disease contraindication 400047006
Respiratory insufficiency contraindication 409623005
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Chronic myocardial ischemia contraindication 413844008 DOID:3393
Disorder of coronary artery contraindication 414024009
Myocardial ischemia contraindication 414795007 DOID:3393
Granulocytopenic disorder contraindication 417672002
Myocardial infarction in recovery phase contraindication 418044006
Porphyria contraindication 418470004
Fever greater than 100.4 Fahrenheit contraindication 426000000
Hyperplasia of gingiva contraindication 441798003
Fibrosis of pleura contraindication 442110002
Acute erosive gastritis contraindication 444926003
Smokes tobacco daily contraindication 449868002
Acute exacerbation of asthma contraindication 708038006
Severe Hypoxemia contraindication
Theophylline Toxicity contraindication
HLA-B 1502 Positive Status contraindication
Ergot Alkaloid Toxicity contraindication
Severe Pruritus contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.56 acidic
pKa2 9.25 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel WOMBAT-PK
Nuclear receptor subfamily 1 group I member 2 Nuclear hormone receptor WOMBAT-PK
Nuclear receptor subfamily 1 group I member 3 Nuclear hormone receptor WOMBAT-PK
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 5.60 CHEMBL

External reference:

IDSource
4017422 VUID
N0000145810 NUI
D00506 KEGG_DRUG
57-30-7 SECONDARY_CAS_RN
4017422 VANDF
4017423 VANDF
C0031412 UMLSCUI
CHEBI:8069 CHEBI
UQA PDB_CHEM_ID
4763 PUBCHEM_CID
CHEMBL40 ChEMBL_ID
CHEMBL149972 ChEMBL_ID
D010634 MESH_DESCRIPTOR_UI
DB01174 DRUGBANK_ID
2804 IUPHAR_LIGAND_ID
414 INN_ID
4172 INN_ID
YQE403BP4D UNII
8134 RXNORM
2390 MMSL
4349 MMSL
5272 MMSL
5273 MMSL
d00340 MMSL
001406 NDDF
001407 NDDF
373505007 SNOMEDCT_US
51073002 SNOMEDCT_US
76898000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0121-0531 SOLUTION 20 mg ORAL unapproved drug other 29 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0143-1445 TABLET 15 mg ORAL UNULLPPROVED DRUG OTHER 17 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0143-1450 TABLET 30 mg ORAL UNULLPPROVED DRUG OTHER 17 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0143-1455 TABLET 60 mg ORAL UNULLPPROVED DRUG OTHER 17 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0143-1458 TABLET 100 mg ORAL UNULLPPROVED DRUG OTHER 17 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0143-1495 TABLET 15 mg ORAL UNULLPPROVED DRUG OTHER 17 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0143-1500 TABLET 30 mg ORAL UNULLPPROVED DRUG OTHER 17 sections
Belladonna Alkaloids with Phenobartbital HUMAN PRESCRIPTION DRUG LABEL 4 0440-7183 TABLET 16.20 mg ORAL UNULLPPROVED DRUG OTHER 14 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0463-6145 TABLET 30 mg ORAL UNULLPPROVED DRUG OTHER 17 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0463-6151 TABLET 60 mg ORAL UNULLPPROVED DRUG OTHER 17 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0463-6160 TABLET 15 mg ORAL UNULLPPROVED DRUG OTHER 17 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0463-6170 TABLET 100 mg ORAL UNULLPPROVED DRUG OTHER 17 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0603-1508 ELIXIR 20 mg ORAL UNULLPPROVED DRUG OTHER 22 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0603-5165 TABLET 16.20 mg ORAL UNULLPPROVED DRUG OTHER 22 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0603-5166 TABLET 32.40 mg ORAL UNULLPPROVED DRUG OTHER 22 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0603-5167 TABLET 64.80 mg ORAL UNULLPPROVED DRUG OTHER 22 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0603-5168 TABLET 97.20 mg ORAL UNULLPPROVED DRUG OTHER 22 sections
Phenobarbital Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0641-0476 INJECTION 65 mg INTRAMUSCULAR UNULLPPROVED DRUG OTHER 19 sections
Phenobarbital Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0641-0477 INJECTION 130 mg INTRAMUSCULAR UNULLPPROVED DRUG OTHER 19 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 0904-6575 TABLET 32.40 mg ORAL Unapproved drug other 22 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 13517-107 ELIXIR 20 mg ORAL unapproved drug other 23 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 13517-110 TABLET 16.20 mg ORAL unapproved drug other 25 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 13517-111 TABLET 32.40 mg ORAL unapproved drug other 25 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 13517-112 TABLET 64.80 mg ORAL unapproved drug other 25 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 13517-113 TABLET 97.20 mg ORAL unapproved drug other 25 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 13517-755 TABLET 15 mg ORAL unapproved drug other 17 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 13517-756 TABLET 30 mg ORAL unapproved drug other 17 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 13517-757 TABLET 60 mg ORAL unapproved drug other 17 sections
Phenobarbital HUMAN PRESCRIPTION DRUG LABEL 1 13517-758 TABLET 100 mg ORAL unapproved drug other 17 sections
Phenobarbital Human Prescription Drug Label 1 16571-667 TABLET 64.80 mg ORAL UNULLPPROVED DRUG OTHER 21 sections