phenformin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antihyperglycaemics, phenformin derivatives	2126	114-86-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: phenformin phenformin hydrochloride phenformin HCl	A biguanide hypoglycemic agent with actions and uses similar to those of METFORMIN. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290) Molecular weight: 205.27 Formula: C10H15N5 CLOGP: -1.03 LIPINSKI: 0 HAC: 5 HDO: 5 TPSA: 97.78 ALOGS: -2.95 ROTB: 3

Molecule

Description

Molfile Inchi Smiles

Synonyms:

phenformin
phenformin hydrochloride
phenformin HCl

A biguanide hypoglycemic agent with actions and uses similar to those of METFORMIN. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)

Molecular weight: 205.27
Formula: C10H15N5
CLOGP: -1.03
LIPINSKI: 0
HAC: 5
HDO: 5
TPSA: 97.78
ALOGS: -2.95
ROTB: 3

Drug dosage:

Dose	Unit	Route
0.10	g	O

ADMET properties:

Property	Value	Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)	8.14 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System)	3	Hosey CM, Chan R, Benet LZ
BA (Bioavailability)	55 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
S (Water solubility)	48 mg/mL	Bocci G, Oprea TI, Benet LZ

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A10BA01	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS Biguanides
ATC	A10BD01	ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS Combinations of oral blood glucose lowering drugs
MeSH PA	D007004	Hypoglycemic Agents
CHEBI has role	CHEBI:35526	antidiabetic
CHEBI has role	CHEBI:35610	antineoplastic agents
CHEBI has role	CHEBI:176497	geroprotectors

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	11.51	Basic
pKa2	2.78	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
5'-AMP-activated protein kinase subunit beta-1	Kinase	Q9Y478	AAKB1_HUMAN					WOMBAT-PK

External reference:

ID	Source
4025255	VUID
N0000171785	NUI
D08351	KEGG_DRUG
4025255	VANDF
C0031404	UMLSCUI
CHEBI:8064	CHEBI
8CV	PDB_CHEM_ID
CHEMBL170988	ChEMBL_ID
DB00914	DRUGBANK_ID
D010629	MESH_DESCRIPTOR_UI
8249	PUBCHEM_CID
931	INN_ID
834-28-6	SECONDARY_CAS_RN
DD5K7529CE	UNII
235288	RXNORM
000914	NDDF
004533	NDDF
362949009	SNOMEDCT_US
CHEMBL1528839	ChEMBL_ID

Pharmaceutical products:

None