perospirone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
anxiolytics, buspirone derivatives	2112	150915-41-6

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

perospirone
lullan
SM-9018
SM 9018
perospirone hydrochloride
perospirone hydrochloride dihydrate
perospirone HCl
perospirone hydrochloride hydrate

Molecular weight: 426.58
Formula: C23H30N4O2S
CLOGP: 4.21
LIPINSKI: 0
HAC: 6
HDO: 0
TPSA: 56.75
ALOGS: -4.13
ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Dec. 22, 2000	PMDA	Sumitomo Dainippon

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Parkinsonism	50.88	46.34	13	456	16571	79727348
Altered state of consciousness	50.58	46.34	16	453	43806	79700113

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D014150	Antipsychotic Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D014149	Tranquilizing Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Schizophrenia	indication	58214004	DOID:5419

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.29	Basic
pKa2	0.27	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN	ANTAGONIST	Ki	9.22		IUPHAR	IUPHAR
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN	ANTAGONIST	Ki	9.55		IUPHAR
D(4) dopamine receptor	GPCR	P21917	DRD4_HUMAN	ANTAGONIST	Ki	10.05		IUPHAR
5-hydroxytryptamine receptor 2A	GPCR		5HT2A_RAT	ANTAGONIST	Ki	4.74		IUPHAR

External reference:

ID	Source
D02372	KEGG_DRUG
C0084572	UMLSCUI
CHEBI:94777	CHEBI
CHEMBL1472975	ChEMBL_ID
DB08922	DRUGBANK_ID
C065533	MESH_SUPPLEMENTAL_RECORD_UI
115368	PUBCHEM_CID
7556	IUPHAR_LIGAND_ID
7237	INN_ID
129273-38-7	SECONDARY_CAS_RN
192052-81-6	SECONDARY_CAS_RN
N303OK87DT	UNII

Pharmaceutical products:

None