perospirone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anxiolytics, buspirone derivatives 2112 150915-41-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • perospirone
  • lullan
  • SM-9018
  • SM 9018
  • perospirone hydrochloride
  • perospirone hydrochloride dihydrate
  • perospirone HCl
  • perospirone hydrochloride hydrate
  • Molecular weight: 426.58
  • Formula: C23H30N4O2S
  • CLOGP: 3.76
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 0
  • TPSA: 56.75
  • ALOGS: -4.13
  • ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 22, 2000 PMDA Sumitomo Dainippon

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Schizophrenia indication 58214004 DOID:5419

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.29 Basic
pKa2 0.27 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(2) dopamine receptor GPCR ANTAGONIST Ki 9.22 IUPHAR IUPHAR
D(3) dopamine receptor GPCR ANTAGONIST Ki 9.55 IUPHAR
D(4) dopamine receptor GPCR ANTAGONIST Ki 10.05 IUPHAR
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 4.74 IUPHAR

External reference:

IDSource
D02372 KEGG_DRUG
N303OK87DT UNII
7237 INN_ID
192052-81-6 SECONDARY_CAS_RN
C065533 MESH_SUPPLEMENTAL_RECORD_UI
DB08922 DRUGBANK_ID
CHEBI:94777 CHEBI
CHEMBL1472975 ChEMBL_ID
115368 PUBCHEM_CID
7556 IUPHAR_LIGAND_ID

Pharmaceutical products:

None