pemoline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2075 2152-34-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pemoline
  • azoksodon
  • azoxodon
  • azoxodone
  • centramin
  • dantromin
  • pemolin
  • pheniminooxazolidino
  • phenoxazole
  • phenylisohydantoin
  • phenylpseudohydantoi
  • fenoxazol
  • pemoline hydrochloride
  • magnesium pemoline
  • pemoline HCl
A central nervous system stimulant used in fatigue and depressive states and to treat hyperkinetic disorders in children.
  • Molecular weight: 176.18
  • Formula: C9H8N2O2
  • CLOGP: 0.46
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 64.68
  • ALOGS: -2.26
  • ROTB: 1

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
40 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Hosey CM, Chan R, Benet LZ
S (Water solubility) 0.56 mg/mL Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
Jan. 27, 1975 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N06BA05 NERVOUS SYSTEM
PSYCHOANALEPTICS
PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
Centrally acting sympathomimetics
MeSH PA D002491 Central Nervous System Agents
MeSH PA D000697 Central Nervous System Stimulants
CHEBI has role CHEBI:35337 analeptic

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Attention deficit hyperactivity disorder indication 406506008




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.91 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent dopamine transporter Transporter Ki 6.38 DRUG MATRIX

External reference:

IDSource
4018726 VUID
N0000147031 NUI
D00744 KEGG_DRUG
4018726 VANDF
C0030800 UMLSCUI
CHEBI:7953 CHEBI
CHEMBL1177 ChEMBL_ID
DB01230 DRUGBANK_ID
D010389 MESH_DESCRIPTOR_UI
4723 PUBCHEM_CID
1054 INN_ID
7GAQ2332NK UNII
7966 RXNORM
31002 MMSL
5240 MMSL
d00901 MMSL
001384 NDDF
006725 NDDF
006726 NDDF
387393000 SNOMEDCT_US
70776005 SNOMEDCT_US

Pharmaceutical products:

None