pemirolast 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antiasthmatics or antiallergics, not acting primarily as antihistaminics anti-allergic or anti-inflammatory, not acting as anti-histaminics 2074 69372-19-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alamast
  • pemirolast
  • pemirolast potassium
  • alegysal
  • potassium pemirolast
  • Molecular weight: 228.22
  • Formula: C10H8N6O
  • CLOGP: 0.30
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 87.13
  • ALOGS: -2.72
  • ROTB: 1

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 24, 1999 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D018494 Histamine Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D018377 Neurotransmitter Agents
FDA PE N0000175628 Decreased Histamine Release
FDA EPC N0000175630 Mast Cell Stabilizer

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Allergic rhinitis indication 61582004
Asthma indication 195967001 DOID:2841
Allergic conjunctivitis indication 473460002 DOID:11204




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.26 acidic
pKa2 3.56 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4021298 VUID
N0000148735 NUI
D01088 KEGG_DRUG
100299-08-9 SECONDARY_CAS_RN
4021210 VANDF
4021211 VANDF
4021298 VANDF
4021299 VANDF
C0053881 UMLSCUI
CHEBI:134936 CHEBI
CHEMBL1201198 ChEMBL_ID
DB00885 DRUGBANK_ID
CHEMBL1201050 ChEMBL_ID
57697 PUBCHEM_CID
C055139 MESH_SUPPLEMENTAL_RECORD_UI
7329 IUPHAR_LIGAND_ID
6449 INN_ID
2C09NV773M UNII
19551 RXNORM
31417 MMSL
8304 MMSL
008300 NDDF
008301 NDDF
116112001 SNOMEDCT_US
417508009 SNOMEDCT_US
417669009 SNOMEDCT_US

Pharmaceutical products:

None