pemirolast Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antiasthmatics or antiallergics, not acting primarily as antihistaminics anti-allergic or anti-inflammatory, not acting as anti-histaminics 2074 69372-19-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alamast
  • pemirolast
  • pemirolast potassium
  • alegysal
  • potassium pemirolast
  • Molecular weight: 228.22
  • Formula: C10H8N6O
  • CLOGP: 0.57
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 87.13
  • ALOGS: -2.72
  • ROTB: 1

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 24, 1999 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
FDA PE N0000175628 Decreased Histamine Release
FDA EPC N0000175630 Mast Cell Stabilizer
MeSH PA D018494 Histamine Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D018377 Neurotransmitter Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Allergic rhinitis indication 61582004
Asthma indication 195967001 DOID:2841
Allergic conjunctivitis indication 473460002 DOID:11204

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.26 acidic
pKa2 3.56 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4021298 VUID
N0000148735 NUI
C0053881 UMLSCUI
D01088 KEGG_DRUG
2C09NV773M UNII
6449 INN_ID
100299-08-9 SECONDARY_CAS_RN
417669009 SNOMEDCT_US
4021210 VANDF
417508009 SNOMEDCT_US
19551 RXNORM
4021298 VANDF
008300 NDDF
57697 PUBCHEM_CID
CHEBI:134936 CHEBI
DB00885 DRUGBANK_ID
CHEMBL1201050 ChEMBL_ID
CHEMBL1201198 ChEMBL_ID
7329 IUPHAR_LIGAND_ID
C055139 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None