paromomycin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, produced by Streptomyces strains 2067 7542-37-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ameparomo
  • paromomycin
  • aminosidin
  • aminosidine
  • catenulin
  • crestomycin
  • paromomycine
  • paucimycin
  • paromomycin sulfate
  • paromomycin sulphate
An aminoglycoside antibacterial and antiprotozoal agent produced by species of STREPTOMYCES.
  • Molecular weight: 615.63
  • Formula: C23H45N5O14
  • CLOGP: -6.52
  • LIPINSKI: 3
  • HAC: 19
  • HDO: 13
  • TPSA: 347.32
  • ALOGS: -0.89
  • ROTB: 9
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
3 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Hosey CM, Chan R, Benet LZ
BA (Bioavailability) 2 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
S (Water solubility) 100 mg/mL Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
March 24, 1969 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A07AA06 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFECTIVES
Antibiotics
FDA EPC N0000175485 Antiprotozoal
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000981 Antiprotozoal Agents
CHEBI has role CHEBI:35442 antiparasitic drugs
CHEBI has role CHEBI:35443 anthelmintics
CHEBI has role CHEBI:35820 antiprotozoal drugs
CHEBI has role CHEBI:36047 antibacterial drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Acute amebiasis indication 39224005
Hepatic coma indication 72836002 DOID:12550
Chronic intestinal amebiasis indication 186117001
Infection by Cryptosporidium off-label use 58777003
Intestinal Parasitic Infections off-label use
Hearing loss contraindication 15188001
Gastrointestinal ulcer contraindication 40845000
Kidney disease contraindication 90708001 DOID:557
Gastrointestinal obstruction contraindication 126765001
Disorder of the 8th Cranial Nerve contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.52 acidic
pKa2 12.96 acidic
pKa3 13.68 acidic
pKa4 8.21 Basic
pKa5 7.69 Basic
pKa6 6.9 Basic
pKa7 6.3 Basic
pKa8 6.05 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019878 VUID
N0000147963 NUI
D00868 KEGG_DRUG
1263-89-4 SECONDARY_CAS_RN
4018638 VANDF
4019878 VANDF
C0030576 UMLSCUI
CHEBI:7934 CHEBI
PAR PDB_CHEM_ID
CHEMBL370143 ChEMBL_ID
CHEMBL2206196 ChEMBL_ID
D010303 MESH_DESCRIPTOR_UI
DB01421 DRUGBANK_ID
12160 IUPHAR_LIGAND_ID
939 INN_ID
61JJC8N5ZK UNII
165580 PUBCHEM_CID
66912 RXNORM
169406 MMSL
35335 MMSL
35391 MMSL
5235 MMSL
d01104 MMSL
002956 NDDF
004965 NDDF
30203009 SNOMEDCT_US
370323004 SNOMEDCT_US
38044001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Paromomycin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 23155-038 CAPSULE 250 mg ORAL ANDA 11 sections
Paromomycin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 55695-022 CAPSULE 250 mg ORAL ANDA 11 sections
Paromomycin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 76413-147 CAPSULE 250 mg ORAL ANDA 11 sections
Humatin HUMAN PRESCRIPTION DRUG LABEL 1 80725-250 CAPSULE 250 mg ORAL ANDA 11 sections
Humatin HUMAN PRESCRIPTION DRUG LABEL 1 80725-250 CAPSULE 250 mg ORAL ANDA 11 sections