paromomycin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, produced by Streptomyces strains 2067 7542-37-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ameparomo
  • paromomycin
  • aminosidin
  • aminosidine
  • catenulin
  • crestomycin
  • paromomycine
  • paucimycin
  • paromomycin sulfate
  • paromomycin sulphate
An aminoglycoside antibacterial and antiprotozoal agent produced by species of STREPTOMYCES.
  • Molecular weight: 615.63
  • Formula: C23H45N5O14
  • CLOGP: -6.52
  • LIPINSKI: 3
  • HAC: 19
  • HDO: 13
  • TPSA: 347.32
  • ALOGS: -0.89
  • ROTB: 9

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
3 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Hosey CM, Chan R, Benet LZ
BA (Bioavailability) 2 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
March 24, 1969 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC A07AA06 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFECTIVES
Antibiotics
FDA EPC N0000175485 Antiprotozoal
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000981 Antiprotozoal Agents
CHEBI has role CHEBI:36047 antibacterial drug
CHEBI has role CHEBI:35820 antiprotozoal drug
CHEBI has role CHEBI:35443 anthelminthic drug
CHEBI has role CHEBI:35442 antiparasitic agent

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Acute amebiasis indication 39224005
Hepatic coma indication 72836002 DOID:12550
Chronic intestinal amebiasis indication 186117001
Infection by Cryptosporidium off-label use 58777003
Intestinal Parasitic Infections off-label use
Hearing loss contraindication 15188001
Gastrointestinal ulcer contraindication 40845000
Kidney disease contraindication 90708001 DOID:557
Gastrointestinal obstruction contraindication 126765001
Disorder of the 8th Cranial Nerve contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.52 acidic
pKa2 12.96 acidic
pKa3 13.68 acidic
pKa4 8.21 Basic
pKa5 7.69 Basic
pKa6 6.9 Basic
pKa7 6.3 Basic
pKa8 6.05 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019878 VUID
N0000147963 NUI
C0030576 UMLSCUI
D00868 KEGG_DRUG
61JJC8N5ZK UNII
939 INN_ID
35391 MMSL
370323004 SNOMEDCT_US
4019878 VANDF
7934 RXNORM
38044001 SNOMEDCT_US
d01104 MMSL
004965 NDDF
1263-89-4 SECONDARY_CAS_RN
CHEMBL370143 ChEMBL_ID
PAR PDB_CHEM_ID
DB01421 DRUGBANK_ID
CHEBI:7934 CHEBI
D010303 MESH_DESCRIPTOR_UI
CHEMBL2206196 ChEMBL_ID
165580 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Paromomycin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 23155-038 CAPSULE 250 mg ORAL ANDA 9 sections
Paromomycin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 55695-022 CAPSULE 250 mg ORAL ANDA 9 sections
Paromomycin Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 76413-147 CAPSULE 250 mg ORAL ANDA 9 sections