pantoprazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antiulcer, benzimidazole derivatives 2054 102625-70-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pantoprazole
  • pantozol
  • pantoprazole sodium
  • controloc control
  • pantoprazole sodium hydrate
  • pantoprazole sodium sesquihydrate
Pantoprazole sodium is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production by covalently binding to the (H+, K+)-ATPase enzyme system at the secretory surface of the gastric parietal cell. This effect leads to inhibition of both basal and stimulated gastric acid secretion, irrespective of the stimulus. The binding to the (H+, K+)-ATPase results in a duration of antisecretory effect that persists longer than 24 hours.
  • Molecular weight: 383.37
  • Formula: C16H15F2N3O4S
  • CLOGP: 2.11
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 86.33
  • ALOGS: -2.89
  • ROTB: 7
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
40 mg O
40 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.74 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.17 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.20 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.90 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Feb. 2, 2000 FDA WYETH PHARMS INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 828.34 10.45 3676 541616 197726 62746004
Toxicity to various agents 616.93 10.45 729 544563 246521 62697209
Completed suicide 546.88 10.45 284 545008 145389 62798341
Chronic kidney disease 514.94 10.45 1178 544114 44220 62899510
Drug ineffective 416.53 10.45 6400 538892 1038365 61905365
Muscle injury 338.70 10.45 1282 544010 64063 62879667
Folliculitis 337.16 10.45 1346 543946 68971 62874759
Irritable bowel syndrome 313.41 10.45 1471 543821 80941 62862789
Haematochezia 292.94 10.45 1069 544223 52475 62891255
Product prescribing error 252.74 10.45 640 544652 25649 62918081
Lower respiratory tract infection 249.80 10.45 1968 543324 130339 62813391
Sleep disorder due to general medical condition, insomnia type 238.72 10.45 985 544307 51232 62892498
Exposure during pregnancy 235.12 10.45 627 544665 154920 62788810
Impaired healing 234.64 10.45 1597 543695 100945 62842785
Death 227.55 10.45 2087 543205 372294 62571436
Device expulsion 223.17 10.45 21 545271 34901 62908829
Injection site pain 193.28 10.45 527 544765 129273 62814457
Acute kidney injury 191.27 10.45 3252 542040 260163 62683567
Anaemia 191.25 10.45 3561 541731 289869 62653861
Intentional overdose 190.74 10.45 213 545079 73939 62869791
Injection site erythema 189.75 10.45 262 545030 82912 62860818
Abdominal pain upper 189.06 10.45 2651 542641 203793 62739937
Stomatitis 185.20 10.45 1914 543378 136811 62806919
Abortion spontaneous 179.99 10.45 90 545202 47105 62896625
Hyponatraemia 176.47 10.45 1599 543693 110301 62833429
Injection site reaction 173.81 10.45 148 545144 58376 62885354
Blister 171.82 10.45 1788 543504 128026 62815704
Gastrointestinal disorder 166.85 10.45 1793 543499 129446 62814284
Systemic infection 163.43 10.45 201 545091 4459 62939271
Ill-defined disorder 161.39 10.45 1229 544063 80526 62863204
End stage renal disease 159.08 10.45 239 545053 6454 62937276
Renal injury 156.93 10.45 287 545005 9152 62934578
Drug abuse 156.02 10.45 238 545054 72280 62871450
Peripheral swelling 151.85 10.45 3164 542128 262778 62680952
Hypomagnesaemia 150.66 10.45 566 544726 28171 62915559
Dyspnoea 148.83 10.45 7021 538271 654292 62289438
Off label use 139.43 10.45 4575 540717 669887 62273843
Labelled drug-drug interaction medication error 139.14 10.45 336 544956 13063 62930667
Muscle spasticity 139.06 10.45 458 544834 21336 62922394
Product dose omission issue 138.35 10.45 1315 543977 232998 62710732
Confusional state 136.44 10.45 2817 542475 233563 62710167
Wrong technique in product usage process 122.53 10.45 217 545075 62123 62881607
Maternal exposure during pregnancy 117.07 10.45 1266 544026 218796 62724934
Sinusitis 115.73 10.45 2654 542638 223999 62719731
Product monitoring error 115.61 10.45 167 545125 4349 62939381
Abdominal pain 113.04 10.45 3310 541982 290146 62653584
Drug hypersensitivity 111.72 10.45 1936 543356 308751 62634979
Treatment failure 110.37 10.45 1134 544158 197909 62745821
Asthenia 105.27 10.45 4159 541133 379445 62564285
Night sweats 104.39 10.45 748 544544 48066 62895664
Injection site swelling 104.38 10.45 154 545138 47418 62896312
Body temperature increased 103.48 10.45 609 544683 36583 62907147
Ear pain 100.87 10.45 592 544700 35526 62908204
Orthostatic intolerance 98.55 10.45 82 545210 1115 62942615
Hypokalaemia 98.15 10.45 1341 543951 102463 62841267
Disease progression 96.01 10.45 638 544654 122120 62821610
Haematemesis 95.20 10.45 514 544778 29898 62913832
Sedation complication 94.82 10.45 6 545286 13816 62929914
Injection site pruritus 94.24 10.45 151 545141 44965 62898765
Tubulointerstitial nephritis 93.75 10.45 379 544913 19524 62924206
No adverse event 87.98 10.45 137 545155 41268 62902462
Hepatic function abnormal 87.74 10.45 114 545178 37028 62906702
Overdose 87.54 10.45 603 544689 114475 62829255
Liver injury 86.95 10.45 848 544444 59672 62884058
Drug resistance 84.09 10.45 46 545246 22887 62920843
Pruritus 83.63 10.45 3850 541442 357603 62586127
Premature delivery 83.46 10.45 82 545210 30199 62913531
Weight increased 82.44 10.45 2873 542419 257919 62685811
Accidental exposure to product 81.73 10.45 69 545223 27336 62916394
Foetal exposure during pregnancy 79.80 10.45 94 545198 31868 62911862
Subacute cutaneous lupus erythematosus 78.52 10.45 105 545187 2538 62941192
Rheumatoid arthritis 77.70 10.45 2786 542506 251033 62692697
Melaena 77.36 10.45 486 544806 29879 62913851
Suicidal ideation 76.27 10.45 277 545015 62144 62881586
Neuropathy peripheral 75.80 10.45 618 544674 113049 62830681
Agranulocytosis 74.12 10.45 418 544874 24716 62919014
Sedation 73.66 10.45 138 545154 38671 62905059
Hypocalcaemia 73.12 10.45 495 544797 31218 62912512
Respiratory arrest 70.33 10.45 107 545185 32538 62911192
Therapeutic product effect incomplete 69.88 10.45 711 544581 124345 62819385
Pyrexia 69.51 10.45 4810 540482 465668 62478062
Cardio-respiratory arrest 68.77 10.45 273 545019 59686 62884044
Myelosuppression 67.89 10.45 62 545230 23641 62920089
Eosinophilia 67.47 10.45 379 544913 22377 62921353
Respiratory disorder 66.49 10.45 568 544724 38514 62905216
Seizure 66.15 10.45 774 544518 131860 62811870
Contusion 65.42 10.45 1720 543572 148324 62795406
Injection site bruising 64.74 10.45 167 545125 41743 62901987
Infection 62.80 10.45 2485 542807 226688 62717042
Helicobacter infection 62.70 10.45 1133 544159 91652 62852078
Feeling abnormal 61.51 10.45 900 544392 147492 62796238
White blood cell count decreased 61.44 10.45 833 544459 138271 62805459
Drug dependence 60.06 10.45 73 545219 24410 62919320
Depression 59.02 10.45 1262 544030 195230 62748500
Gastrointestinal haemorrhage 58.69 10.45 1002 544290 80174 62863556
Product use in unapproved indication 58.60 10.45 1134 544158 177946 62765784
Suicide attempt 58.08 10.45 297 544995 60621 62883109
Therapeutic response decreased 57.51 10.45 302 544990 61223 62882507
Coma 57.37 10.45 321 544971 64043 62879687
Malaise 56.52 10.45 2958 542334 412996 62530734
Intentional self-injury 55.52 10.45 84 545208 25603 62918127
Therapeutic drug monitoring analysis not performed 55.15 10.45 63 545229 1289 62942441
Leukopenia 54.42 10.45 950 544342 76340 62867390
Anaphylactic reaction 53.45 10.45 340 544952 65760 62877970
Gastritis 53.23 10.45 522 544770 36781 62906949
Irritability 52.32 10.45 122 545170 31572 62912158
Lung diffusion test abnormal 52.11 10.45 34 545258 309 62943421
Caesarean section 51.88 10.45 42 545250 16990 62926740
Device difficult to use 50.94 10.45 23 545269 12773 62930957
Cachexia 50.51 10.45 135 545157 5591 62938139
Duodenal ulcer perforation 50.44 10.45 1040 544252 86169 62857561
Balance disorder 49.65 10.45 474 544818 83948 62859782
Dystonia 48.83 10.45 29 545263 13790 62929940
Intentional product misuse 48.41 10.45 315 544977 60602 62883128
Hypertensive nephropathy 48.23 10.45 42 545250 610 62943120
Faecaloma 48.10 10.45 164 545128 7777 62935953
Platelet count decreased 47.86 10.45 705 544587 115417 62828313
Renal failure 47.38 10.45 1335 543957 116317 62827413
Electrolyte imbalance 47.26 10.45 315 544977 19761 62923969
Breast cancer stage I 47.23 10.45 3 545289 6886 62936844
Somnolence 45.21 10.45 1178 544114 177507 62766223
Breast cancer 44.93 10.45 238 545054 48145 62895585
Flushing 44.84 10.45 420 544872 74667 62869063
Breast cancer female 44.43 10.45 31 545261 13528 62930202
Neutrophil count decreased 43.65 10.45 294 544998 56112 62887618
Rebound acid hypersecretion 43.62 10.45 30 545262 300 62943430
Premature baby 42.73 10.45 70 545222 20665 62923065
Drug intolerance 42.45 10.45 2192 543100 306469 62637261
Injection site haemorrhage 42.25 10.45 91 545201 24223 62919507
Clostridium test positive 41.88 10.45 88 545204 3113 62940617
Cellulitis 41.34 10.45 477 544815 81481 62862249
Device issue 41.33 10.45 89 545203 23692 62920038
Nasopharyngitis 41.29 10.45 2621 542671 251636 62692094
Vision blurred 40.74 10.45 550 544742 91374 62852356
Psoriatic arthropathy 40.70 10.45 1052 544240 90468 62853262
Blood loss anaemia 40.49 10.45 169 545123 8832 62934898
Neutropenic sepsis 40.34 10.45 49 545243 16389 62927341
Pre-eclampsia 40.32 10.45 14 545278 9119 62934611
Cholestasis 40.12 10.45 408 544884 29026 62914704
Drug reaction with eosinophilia and systemic symptoms 40.07 10.45 456 544836 33380 62910350
Alopecia 39.84 10.45 2433 542859 335103 62608627
Injection site warmth 39.77 10.45 43 545249 15152 62928578
Joint injury 39.68 10.45 126 545166 29446 62914284
Hypoaesthesia 39.52 10.45 1122 544170 167271 62776459
Product storage error 39.51 10.45 42 545250 14914 62928816
Device dislocation 39.26 10.45 103 545189 25602 62918128
Injection site rash 39.23 10.45 63 545229 18746 62924984
Cardiac arrest 38.78 10.45 560 544732 91985 62851745
Bursitis 38.52 10.45 487 544805 36554 62907176
Dyspnoea exertional 38.52 10.45 730 544562 59572 62884158
Genital haemorrhage 38.47 10.45 8 545284 7324 62936406
Vomiting 37.58 10.45 5417 539875 554200 62389530
Mycotic allergy 36.12 10.45 44 545248 966 62942764
Asthma 36.03 10.45 1388 543904 126173 62817557
Abdominal pain lower 35.03 10.45 356 544936 25322 62918408
Drug ineffective for unapproved indication 34.82 10.45 162 545130 33901 62909829
Nasal obstruction 34.47 10.45 57 545235 1674 62942056
Pallor 34.43 10.45 408 544884 30160 62913570
Haematoma 34.19 10.45 453 544839 34367 62909363
Abnormal behaviour 34.16 10.45 84 545208 21342 62922388
Angina pectoris 34.12 10.45 402 544890 29676 62914054
Sleep disorder 33.80 10.45 929 544363 80637 62863093
Drug withdrawal syndrome 33.66 10.45 120 545172 27074 62916656
Product quality issue 33.54 10.45 176 545116 35689 62908041
Adverse drug reaction 33.52 10.45 482 544810 79232 62864498
Pneumonia viral 33.52 10.45 146 545146 7776 62935954
Hyperkinesia 32.45 10.45 55 545237 1649 62942081
Mydriasis 32.23 10.45 33 545259 11923 62931807
Renal impairment 32.14 10.45 990 544302 87365 62856365
Pain in jaw 32.04 10.45 230 545062 43266 62900464
Polyneuropathy 32.02 10.45 225 545067 14364 62929366
Enthesopathy 31.99 10.45 17 545275 8597 62935133
Gastroenteritis clostridial 31.95 10.45 32 545260 560 62943170
Uterine perforation 31.92 10.45 10 545282 6953 62936777
Depressed level of consciousness 31.81 10.45 360 544932 61718 62882012
Obstructive airways disorder 31.69 10.45 294 544998 20405 62923325
Abortion induced 31.52 10.45 25 545267 10217 62933513
Temperature regulation disorder 31.49 10.45 120 545172 6012 62937718
Injection site urticaria 31.41 10.45 45 545247 14028 62929702
Hypoparathyroidism secondary 31.27 10.45 13 545279 39 62943691
Eructation 31.10 10.45 148 545144 8185 62935545
Soft tissue disorder 31.00 10.45 96 545196 4326 62939404
Total lung capacity decreased 30.90 10.45 62 545230 2121 62941609
Device use error 30.82 10.45 6 545286 5755 62937975
Serotonin syndrome 30.76 10.45 134 545158 28548 62915182
Musculoskeletal disorder 30.56 10.45 84 545208 20560 62923170
Device malfunction 30.07 10.45 68 545224 17789 62925941
Spontaneous haemorrhage 29.82 10.45 31 545261 568 62943162
Blood pressure systolic increased 29.66 10.45 572 544720 46825 62896905
Pregnancy with contraceptive device 29.52 10.45 3 545289 4691 62939039
Colitis ulcerative 29.28 10.45 348 544944 25743 62917987
Painful respiration 29.27 10.45 70 545222 2704 62941026
Skin disorder 29.19 10.45 142 545150 29365 62914365
Treatment noncompliance 29.15 10.45 194 545098 37131 62906599
Diabetic nephropathy 29.12 10.45 48 545244 1406 62942324
Coagulation test abnormal 28.92 10.45 35 545257 763 62942967
Breath sounds abnormal 28.81 10.45 177 545115 10796 62932934
Device breakage 28.75 10.45 34 545258 11508 62932222
Sickle cell anaemia with crisis 28.65 10.45 8 545284 5995 62937735
Trimethylaminuria 28.39 10.45 18 545274 155 62943575
Urinary tract obstruction 28.07 10.45 60 545232 2148 62941582
Clostridium difficile colitis 27.97 10.45 285 545007 20284 62923446
Substance abuse 27.95 10.45 4 545288 4803 62938927
Wheezing 27.42 10.45 1042 544250 94553 62849177
Heavy menstrual bleeding 27.31 10.45 71 545221 17702 62926028
Hypochromic anaemia 27.31 10.45 55 545237 1887 62941843
Glomerulonephropathy 27.18 10.45 14 545278 77 62943653
Premature rupture of membranes 27.14 10.45 5 545287 4988 62938742
Headache 26.84 10.45 4910 540382 628331 62315399
Fear of injection 26.81 10.45 14 545278 7150 62936580
Neck pain 26.79 10.45 426 544866 68892 62874838
Anxiety 26.71 10.45 1562 543730 215979 62727751
Pancreatic steatosis 26.64 10.45 38 545254 978 62942752
Gestational diabetes 26.46 10.45 20 545272 8376 62935354
Acute abdomen 26.36 10.45 48 545244 1525 62942205
Poisoning deliberate 25.91 10.45 35 545257 11183 62932547
Hypertensive crisis 25.91 10.45 222 545070 15064 62928666
Neuroleptic malignant syndrome 25.50 10.45 40 545252 12016 62931714
Haemoglobin decreased 25.50 10.45 1510 543782 143975 62799755
Surgery 25.44 10.45 192 545100 35720 62908010
Cardiac failure 25.41 10.45 971 544321 88171 62855559
Blood calcium decreased 25.18 10.45 129 545163 26322 62917408
Iron deficiency anaemia 24.96 10.45 272 545020 19697 62924033
Atrial fibrillation 24.89 10.45 1233 544059 115403 62828327
Dysphoria 24.89 10.45 6 545286 4960 62938770
Hepatitis cholestatic 24.84 10.45 121 545171 6757 62936973
Hiatus hernia 24.66 10.45 289 545003 21305 62922425
Food allergy 24.54 10.45 175 545117 11226 62932504
Vocal cord dysfunction 24.51 10.45 27 545265 530 62943200
Throat clearing 24.41 10.45 60 545232 2359 62941371
Nephrogenic anaemia 24.39 10.45 56 545236 2106 62941624
Hypomania 24.24 10.45 12 545280 6318 62937412
Febrile infection 24.20 10.45 46 545246 1511 62942219
Bacteriuria 24.17 10.45 37 545255 1016 62942714
Oesophageal dilatation 24.12 10.45 23 545269 378 62943352
Multiple sclerosis relapse 24.11 10.45 283 545009 48195 62895535
Restlessness 24.05 10.45 371 544921 29082 62914648
Poisoning 24.03 10.45 51 545241 13649 62930081
Exposure to toxic agent 23.92 10.45 9 545283 5578 62938152
Complication of device insertion 23.87 10.45 18 545274 7546 62936184
Low birth weight baby 23.76 10.45 16 545276 7113 62936617
Dehydration 23.71 10.45 1762 543530 171592 62772138
Body temperature decreased 23.68 10.45 273 545019 20046 62923684
Normal newborn 23.67 10.45 22 545270 8319 62935411
Creatinine renal clearance decreased 23.66 10.45 67 545225 16241 62927489
Disseminated intravascular coagulation 23.62 10.45 84 545208 18967 62924763
Lethargy 23.42 10.45 339 544953 55668 62888062
Loss of personal independence in daily activities 23.39 10.45 646 544646 96644 62847086
Polycystic ovaries 23.21 10.45 5 545287 4466 62939264
Paroxysmal extreme pain disorder 23.18 10.45 13 545279 87 62943643
Joint swelling 23.17 10.45 3182 542110 324484 62619246
Duodenitis 22.90 10.45 78 545214 3697 62940033
Gastric ulcer 22.89 10.45 311 544981 23726 62920004
Amenorrhoea 22.83 10.45 31 545261 9883 62933847
Tachyarrhythmia 22.78 10.45 87 545205 4363 62939367
Musculoskeletal stiffness 22.77 10.45 1325 543967 183293 62760437
Rib deformity 22.74 10.45 19 545273 260 62943470
Stillbirth 22.70 10.45 15 545277 6735 62936995
Wheelchair user 22.70 10.45 13 545279 6306 62937424
Multiple-drug resistance 22.69 10.45 8 545284 5162 62938568
Thrombocytopenia 22.67 10.45 1548 543744 149609 62794121
Paresis 22.67 10.45 60 545232 2470 62941260
Cerebral ischaemia 22.62 10.45 116 545176 6612 62937118
Abnormal faeces 22.43 10.45 100 545192 5380 62938350
Deafness 22.38 10.45 79 545213 17878 62925852
Chronic gastritis 22.12 10.45 64 545228 2777 62940953
Drug eruption 21.98 10.45 150 545142 28544 62915186
Epstein-Barr virus infection 21.95 10.45 22 545270 8028 62935702
Upper gastrointestinal haemorrhage 21.84 10.45 253 545039 18599 62925131
Therapeutic product effect decreased 21.81 10.45 1935 543357 191252 62752478
Colitis erosive 21.81 10.45 13 545279 99 62943631
Brain contusion 21.76 10.45 26 545266 559 62943171
Therapy non-responder 21.75 10.45 491 544801 75410 62868320
Dysuria 21.74 10.45 409 544883 33329 62910401
Hyperkalaemia 21.52 10.45 614 544678 53589 62890141
Impaired quality of life 21.22 10.45 55 545237 13728 62930002
Therapeutic drug monitoring analysis incorrectly performed 21.20 10.45 20 545272 324 62943406
Urosepsis 21.19 10.45 248 545044 18276 62925454
Unevaluable event 21.15 10.45 312 544980 51074 62892656
Synovial fluid analysis 21.10 10.45 57 545235 2376 62941354
Gamma-glutamyltransferase increased 21.05 10.45 410 544882 33621 62910109
Therapy partial responder 21.03 10.45 37 545255 10621 62933109
Blood pressure diastolic abnormal 20.99 10.45 204 545088 14338 62929392
Shock 20.91 10.45 117 545175 23346 62920384
Complication of device removal 20.85 10.45 9 545283 5133 62938597
Hepatitis acute 20.81 10.45 142 545150 8978 62934752
Product complaint 20.59 10.45 50 545242 12759 62930971
Hepatotoxicity 20.51 10.45 211 545081 36830 62906900
Folate deficiency 20.48 10.45 57 545235 2418 62941312
Pathogen resistance 20.48 10.45 15 545277 6383 62937347
Hypochloraemia 20.45 10.45 50 545242 1959 62941771
Vaginal haemorrhage 20.41 10.45 145 545147 27342 62916388
Nightmare 20.39 10.45 90 545202 19104 62924626
Musculoskeletal pain 20.21 10.45 978 544314 91299 62852431
Intermenstrual bleeding 20.12 10.45 23 545269 7903 62935827
Oesophagitis 19.96 10.45 207 545085 14801 62928929
Tachypnoea 19.96 10.45 232 545060 17070 62926660
Red blood cell sedimentation rate increased 19.90 10.45 262 545030 43720 62900010
Occupational asthma 19.87 10.45 14 545278 146 62943584
Spinal pain 19.80 10.45 186 545106 12953 62930777
Hypersensitivity 19.79 10.45 2835 542457 289850 62653880
Peripheral arterial occlusive disease 19.78 10.45 80 545212 4121 62939609
Drug use disorder 19.77 10.45 9 545283 4975 62938755
Akathisia 19.68 10.45 30 545262 9116 62934614
Patent ductus arteriosus 19.67 10.45 6 545286 4244 62939486
Agitation 19.65 10.45 378 544914 59379 62884351
Hepatic enzyme increased 19.64 10.45 2005 543287 200323 62743407
Gastritis erosive 19.53 10.45 103 545189 5936 62937794
Macular degeneration 19.51 10.45 306 544986 24070 62919660
Injection site mass 19.50 10.45 88 545204 18568 62925162
Joint stiffness 19.47 10.45 248 545044 41621 62902109
Cystostomy 19.45 10.45 11 545281 75 62943655
Respiratory depression 19.42 10.45 57 545235 13658 62930072
Medication error 19.32 10.45 587 544705 51697 62892033
Renal cyst 19.28 10.45 153 545139 10149 62933581
Gastrointestinal toxicity 19.07 10.45 23 545269 7718 62936012
Cardiorenal syndrome 19.04 10.45 30 545262 845 62942885
Device deployment issue 19.00 10.45 5 545287 3897 62939833
Prescribed overdose 18.99 10.45 405 544887 33748 62909982
Blood pressure systolic abnormal 18.94 10.45 187 545105 13199 62930531
Neuropathy vitamin B12 deficiency 18.83 10.45 5 545287 0 62943730
Abdominal wall wound 18.76 10.45 11 545281 81 62943649
Degenerative bone disease 18.75 10.45 14 545278 161 62943569
Sexual dysfunction 18.70 10.45 7 545285 4352 62939378
Injection site discolouration 18.62 10.45 24 545268 7824 62935906
Gastric haemorrhage 18.60 10.45 106 545186 6292 62937438
Erysipelas 18.59 10.45 124 545168 7781 62935949
Confusional arousal 18.58 10.45 15 545277 195 62943535
Drug dose omission by device 18.54 10.45 9 545283 4792 62938938
Maternal drugs affecting foetus 18.52 10.45 11 545281 5231 62938499
Pharyngeal dystonia 18.49 10.45 6 545286 6 62943724
Status epilepticus 18.34 10.45 68 545224 15165 62928565
Tenosynovitis stenosans 18.25 10.45 67 545225 3297 62940433
Pneumonia aspiration 18.21 10.45 199 545093 34341 62909389
Hepatic cyst 18.13 10.45 90 545202 5064 62938666
Myocardial infarction 18.10 10.45 688 544604 99205 62844525
Peripheral venous disease 18.06 10.45 208 545084 15269 62928461
Internal haemorrhage 18.03 10.45 90 545202 5075 62938655
Reactive gastropathy 18.00 10.45 21 545271 440 62943290
Tooth disorder 17.89 10.45 155 545137 28002 62915728
Cytomegalovirus infection 17.86 10.45 106 545186 20846 62922884
Chronic respiratory disease 17.72 10.45 14 545278 176 62943554
Troponin abnormal 17.69 10.45 9 545283 48 62943682
Blood glucose increased 17.67 10.45 566 544726 83190 62860540
Demyelination 17.65 10.45 20 545272 6900 62936830
Solar urticaria 17.58 10.45 10 545282 69 62943661
Haemorrhagic erosive gastritis 17.56 10.45 21 545271 452 62943278
Salpingo-oophorectomy unilateral 17.53 10.45 29 545263 852 62942878
Basal cell carcinoma 17.38 10.45 155 545137 27836 62915894
Cholecystitis chronic 17.31 10.45 150 545142 10211 62933519
Inappropriate antidiuretic hormone secretion 17.25 10.45 206 545086 15256 62928474
Complication associated with device 17.20 10.45 81 545211 16897 62926833
Laboratory test abnormal 17.17 10.45 148 545144 26764 62916966
Haematocrit decreased 17.13 10.45 451 544841 38889 62904841
Mood swings 16.81 10.45 90 545202 18158 62925572
Post procedural hypothyroidism 16.78 10.45 16 545276 263 62943467
Pulmonary tuberculosis 16.65 10.45 9 545283 4508 62939222
Adenovirus infection 16.60 10.45 5 545287 3566 62940164
Incorrect dose administered 16.60 10.45 390 544902 59578 62884152
Hepatitis B 16.56 10.45 6 545286 3806 62939924
Orthostatic hypotension 16.51 10.45 215 545077 35945 62907785
Toothache 16.43 10.45 97 545195 19102 62924628
Pseudarthrosis 16.42 10.45 20 545272 439 62943291
Urinary tract infection enterococcal 16.41 10.45 56 545236 2657 62941073
Loss of consciousness 16.36 10.45 838 544454 117283 62826447
Haemarthrosis 16.35 10.45 62 545230 3099 62940631
Jaundice 16.30 10.45 347 544945 28904 62914826
Faeces hard 16.22 10.45 48 545244 2109 62941621
Arterial occlusive disease 16.21 10.45 97 545195 5861 62937869
Oedema peripheral 16.16 10.45 1862 543430 187649 62756081
Sopor 16.16 10.45 274 545018 21890 62921840
Chronic sinusitis 16.08 10.45 175 545117 12668 62931062
Pseudomembranous colitis 16.06 10.45 61 545231 3051 62940679
Acute graft versus host disease 16.06 10.45 9 545283 4419 62939311
Facet joint syndrome 15.94 10.45 167 545125 11971 62931759
Blood parathyroid hormone decreased 15.91 10.45 38 545254 9753 62933977
Femoral hernia incarcerated 15.82 10.45 27 545265 814 62942916
Sensory level abnormal 15.79 10.45 12 545280 142 62943588
Nephritis allergic 15.76 10.45 14 545278 209 62943521
Drug tolerance 15.73 10.45 22 545270 6927 62936803
Lymphoproliferative disorder 15.70 10.45 4 545288 3186 62940544
Tongue disorder 15.70 10.45 43 545249 10537 62933193
Injection site induration 15.64 10.45 35 545257 9191 62934539
Poor venous access 15.63 10.45 195 545097 14590 62929140
Panniculitis 15.63 10.45 48 545244 11337 62932393
Fibromyalgia 15.50 10.45 842 544450 79578 62864152
Colorectal cancer 15.39 10.45 6 545286 3639 62940091
Pericarditis 15.32 10.45 1321 543971 130258 62813472
Foot operation 15.29 10.45 24 545268 7207 62936523
Arterial stenosis 15.11 10.45 22 545270 577 62943153
Pneumonitis chemical 15.08 10.45 14 545278 222 62943508
Cryopyrin associated periodic syndrome 15.07 10.45 17 545275 343 62943387
Anaesthesia oral 15.06 10.45 4 545288 0 62943730
Prerenal failure 14.97 10.45 40 545252 1656 62942074
Neutrophil function disorder 14.94 10.45 6 545286 16 62943714
Pancytopenia 14.94 10.45 995 544297 95938 62847792
Carcinoid tumour of the stomach 14.93 10.45 12 545280 155 62943575
Osteomyelitis 14.91 10.45 147 545145 25873 62917857
Tuberculosis 14.88 10.45 48 545244 11163 62932567
Post procedural pulmonary embolism 14.86 10.45 15 545277 265 62943465
Neutropenia 14.86 10.45 1297 543995 173708 62770022
Psychotic disorder 14.84 10.45 145 545147 25567 62918163
Megacolon 14.77 10.45 43 545249 1872 62941858
Blepharospasm 14.67 10.45 95 545197 5901 62937829
Lip dry 14.66 10.45 200 545092 15270 62928460
Disturbance in social behaviour 14.65 10.45 8 545284 3985 62939745
Posterior reversible encephalopathy syndrome 14.65 10.45 88 545204 17257 62926473
Discontinued product administered 14.64 10.45 9 545283 73 62943657
Bicytopenia 14.53 10.45 51 545241 2454 62941276
Laryngeal stenosis 14.53 10.45 30 545262 1048 62942682
Muscle twitching 14.48 10.45 104 545188 19564 62924166
Product administered to patient of inappropriate age 14.44 10.45 5 545287 3263 62940467
Hepatic vein dilatation 14.43 10.45 6 545286 18 62943712
COVID-19 14.43 10.45 809 544483 112294 62831436
Diverticulum intestinal 14.42 10.45 103 545189 6610 62937120
Shock haemorrhagic 14.38 10.45 139 545153 9756 62933974
Granuloma skin 14.31 10.45 32 545260 8405 62935325
Flatulence 14.30 10.45 395 544897 34307 62909423
Injection site irritation 14.28 10.45 13 545279 4965 62938765
Product use issue 14.23 10.45 1667 543625 218853 62724877
Thrombosis prophylaxis 14.20 10.45 6 545286 19 62943711
Retroperitoneal haematoma 14.14 10.45 56 545236 2857 62940873
Hospitalisation 14.11 10.45 592 544700 84489 62859241
Lipoedema 14.08 10.45 15 545277 283 62943447
Palmar-plantar erythrodysaesthesia syndrome 14.05 10.45 128 545164 22887 62920843
Infusion site pain 14.03 10.45 86 545206 16783 62926947
Intraocular pressure increased 14 10.45 19 545273 6059 62937671
Eosinophils urine present 13.97 10.45 6 545286 20 62943710
Smear cervix abnormal 13.92 10.45 4 545288 2942 62940788
Foetal death 13.89 10.45 48 545244 10932 62932798
Blood iron abnormal 13.88 10.45 8 545284 3868 62939862
Lung opacity 13.88 10.45 59 545233 3109 62940621
Cognitive disorder 13.83 10.45 369 544923 55446 62888284
Deep vein thrombosis postoperative 13.81 10.45 154 545138 11215 62932515
Natural killer cell count decreased 13.81 10.45 7 545285 37 62943693
Subileus 13.77 10.45 59 545233 3120 62940610
Strangury 13.76 10.45 5 545287 9 62943721
Ankylosing spondylitis 13.71 10.45 144 545148 10330 62933400
Cytomegalovirus viraemia 13.69 10.45 17 545275 5632 62938098
Extrapyramidal disorder 13.68 10.45 63 545229 13221 62930509
Alanine aminotransferase increased 13.65 10.45 740 544552 103030 62840700
Graft versus host disease in skin 13.63 10.45 4 545288 2901 62940829
Tetany 13.62 10.45 43 545249 1958 62941772
Clostridium difficile infection 13.60 10.45 345 544947 29577 62914153
Adrenal insufficiency 13.55 10.45 94 545198 17821 62925909
Cardiotoxicity 13.51 10.45 33 545259 8405 62935325
Ischaemic stroke 13.46 10.45 223 545069 17734 62925996
Hepatocellular injury 13.43 10.45 319 544973 27062 62916668
Gastrointestinal complication associated with device 13.42 10.45 5 545287 10 62943720
Epigastric discomfort 13.41 10.45 102 545190 6678 62937052
Underdose 13.38 10.45 161 545131 27295 62916435
Pulmonary embolism 13.35 10.45 1170 544122 115514 62828216
Aortic valve stenosis 13.35 10.45 60 545232 3239 62940491
Coeliac disease 13.20 10.45 168 545124 12629 62931101
Polymyalgia rheumatica 13.20 10.45 66 545226 3725 62940005
Pancreatitis 13.19 10.45 531 544761 48524 62895206
Osteonecrosis of jaw 13.19 10.45 217 545075 34906 62908824
Diastolic dysfunction 13.16 10.45 98 545194 6373 62937357
Gastroenteritis viral 13.12 10.45 135 545157 23565 62920165
TP53 gene mutation 13.10 10.45 7 545285 42 62943688
Pregnancy 13.05 10.45 230 545062 36606 62907124
Feeling jittery 13.00 10.45 174 545118 13229 62930501
Rapid eye movement sleep behaviour disorder 12.98 10.45 15 545277 311 62943419
Clostridium colitis 12.91 10.45 41 545251 1873 62941857
Pain in extremity 12.90 10.45 2581 542711 328905 62614825
Incorrect dosage administered 12.84 10.45 43 545249 2020 62941710
Glucose tolerance impaired 12.82 10.45 23 545269 6554 62937176
Metastases to lung 12.82 10.45 61 545231 12689 62931041
Fracture 12.82 10.45 238 545054 19346 62924384
Flank pain 12.75 10.45 205 545087 16205 62927525
Pharyngitis 12.75 10.45 111 545181 20032 62923698
Hyperprolactinaemia 12.67 10.45 9 545283 3891 62939839
Alanine aminotransferase abnormal 12.64 10.45 12 545280 4492 62939238
Red blood cell count decreased 12.61 10.45 447 544845 40198 62903532
Herpes zoster 12.60 10.45 579 544713 81883 62861847
Dyskinesia 12.59 10.45 196 545096 31806 62911924
Haematotoxicity 12.54 10.45 40 545252 9336 62934394
Prescribed underdose 12.54 10.45 339 544953 29350 62914380
Total lung capacity abnormal 12.51 10.45 8 545284 70 62943660
Disability assessment scale score increased 12.49 10.45 58 545234 3175 62940555
Therapeutic response unexpected 12.49 10.45 102 545190 18657 62925073
Acute megakaryocytic leukaemia 12.46 10.45 7 545285 47 62943683
Stoma site discharge 12.44 10.45 36 545256 1562 62942168
Glomerular filtration rate decreased 12.43 10.45 173 545119 13268 62930462
Productive cough 12.42 10.45 663 544629 62545 62881185
Lymphadenopathy 12.42 10.45 244 545048 38214 62905516
Duodenal polyp 12.39 10.45 10 545282 130 62943600
Metastases to bone 12.36 10.45 118 545174 20901 62922829
Carcinoid tumour 12.34 10.45 16 545276 375 62943355
Metabolic surgery 12.32 10.45 31 545261 1237 62942493
Tardive dyskinesia 12.28 10.45 35 545257 8467 62935263
Fear 12.28 10.45 82 545210 15684 62928046
Type I hypersensitivity 12.28 10.45 54 545238 2888 62940842
Hyperreflexia 12.26 10.45 20 545272 5914 62937816
Blood pressure measurement 12.24 10.45 14 545278 287 62943443
Nephrolithiasis 12.19 10.45 271 545021 41713 62902017
Dermatitis acneiform 12.15 10.45 15 545277 4981 62938749
Biliary dyskinesia 12.09 10.45 51 545241 2678 62941052
Hyperammonaemic encephalopathy 12.08 10.45 3 545289 2431 62941299
Dermatitis contact 12.07 10.45 51 545241 10957 62932773
Paralysis 12.04 10.45 44 545248 9856 62933874
Monoparesis 12.04 10.45 36 545256 1591 62942139
Non-economic loss 12.03 10.45 5 545287 15 62943715
Therapy interrupted 12.03 10.45 201 545091 32254 62911476
White blood cell count abnormal 12.02 10.45 22 545270 6220 62937510
Dissociation 12.01 10.45 5 545287 2914 62940816
Somatic symptom disorder 12.01 10.45 50 545242 2610 62941120
Petit mal epilepsy 12.01 10.45 9 545283 3785 62939945
Gastrointestinal inflammation 11.99 10.45 86 545206 5526 62938204
Sebaceous gland infection 11.98 10.45 11 545281 172 62943558
Labelled drug-food interaction medication error 11.92 10.45 11 545281 173 62943557
Prothrombin time shortened 11.91 10.45 41 545251 1954 62941776
Pulmonary fibrosis 11.91 10.45 436 544856 39373 62904357
Congenital coronary artery malformation 11.90 10.45 10 545282 138 62943592
Gastrointestinal vascular malformation haemorrhagic 11.85 10.45 12 545280 213 62943517
Enteritis 11.84 10.45 116 545176 8170 62935560
Pruritus genital 11.83 10.45 4 545288 2650 62941080
Cardiac failure congestive 11.82 10.45 661 544631 91772 62851958
Aortic occlusion 11.81 10.45 9 545283 107 62943623
Spigelian hernia 11.80 10.45 6 545286 32 62943698
Arterial haemorrhage 11.78 10.45 37 545255 1680 62942050
Dental caries 11.78 10.45 50 545242 10729 62933001
Eye pruritus 11.77 10.45 103 545189 18568 62925162
Embolism venous 11.76 10.45 56 545236 3098 62940632
Paradoxical drug reaction 11.72 10.45 11 545281 4141 62939589
Incorrect dose administered by device 11.72 10.45 12 545280 4336 62939394
Bacterial test 11.72 10.45 29 545263 1145 62942585
Deja vu 11.71 10.45 8 545284 79 62943651
Unresponsive to stimuli 11.71 10.45 212 545080 33604 62910126
Mucormycosis 11.68 10.45 5 545287 2866 62940864
Hypergastrinaemia 11.67 10.45 9 545283 109 62943621
Device use issue 11.66 10.45 4 545288 2626 62941104
Presyncope 11.66 10.45 317 544975 27468 62916262
Stress 11.64 10.45 465 544827 66702 62877028
Neurosensory hypoacusis 11.63 10.45 12 545280 218 62943512
Bone disorder 11.59 10.45 122 545170 21204 62922526
Mixed liver injury 11.57 10.45 75 545217 4660 62939070
Haemoptysis 11.56 10.45 326 544966 28400 62915330
Stenosis 11.56 10.45 33 545259 1421 62942309
Cholecystitis 11.54 10.45 191 545101 15186 62928544
Sputum discoloured 11.52 10.45 201 545091 16146 62927584
Renal haemangioma 11.51 10.45 6 545286 34 62943696
Eye disorder 11.45 10.45 132 545160 22553 62921177
Withdrawal syndrome 11.45 10.45 113 545179 19884 62923846
Glomerulonephritis chronic 11.44 10.45 10 545282 146 62943584
Enterochromaffin cell hyperplasia 11.36 10.45 7 545285 57 62943673
Adverse reaction 11.35 10.45 47 545245 10156 62933574
Blood pressure ambulatory abnormal 11.30 10.45 3 545289 0 62943730
Speech rehabilitation 11.30 10.45 3 545289 0 62943730
Gastrointestinal wall thickening 11.29 10.45 32 545260 1372 62942358
Spinal compression fracture 11.27 10.45 74 545218 14209 62929521
Pneumocystis jirovecii pneumonia 11.25 10.45 92 545200 16822 62926908
Rash maculo-papular 11.22 10.45 356 544936 31540 62912190
Vitamin B12 decreased 11.20 10.45 61 545231 3559 62940171
Gastrointestinal angiodysplasia 11.18 10.45 17 545275 464 62943266
Administration site discomfort 11.16 10.45 8 545284 86 62943644
Tricuspid valve incompetence 11.12 10.45 182 545110 14439 62929291
Interstitial lung disease 11.07 10.45 427 544865 61481 62882249
Suspected suicide 11.07 10.45 25 545267 6543 62937187
Lung disorder 11.05 10.45 647 544645 61614 62882116
Dysphagia 11.04 10.45 894 544398 87691 62856039
Neurotoxicity 11.03 10.45 93 545199 16897 62926833
Coma scale abnormal 10.99 10.45 17 545275 5136 62938594
Ventricular tachycardia 10.98 10.45 114 545178 19865 62923865
Vaccination site reaction 10.96 10.45 9 545283 120 62943610
Gangrene 10.95 10.45 90 545202 6033 62937697
Humerus fracture 10.94 10.45 121 545171 8795 62934935
Cardiovascular disorder 10.91 10.45 152 545140 11660 62932070
Cerebellar ataxia 10.89 10.45 24 545268 878 62942852
Gait deviation 10.88 10.45 7 545285 62 62943668
Mobility decreased 10.87 10.45 894 544398 120265 62823465
Limb deformity 10.84 10.45 11 545281 3991 62939739
Bone lesion 10.82 10.45 87 545205 5794 62937936
Cushingoid 10.80 10.45 116 545176 8369 62935361
Faeces discoloured 10.78 10.45 221 545071 18288 62925442
Osteonecrosis 10.78 10.45 147 545145 24383 62919347
Application site pain 10.76 10.45 12 545280 4170 62939560
Lymphatic fistula 10.74 10.45 22 545270 764 62942966
Rhabdomyolysis 10.74 10.45 471 544821 43480 62900250
Hallucination 10.72 10.45 374 544918 54443 62889287
Iron deficiency 10.72 10.45 102 545190 7128 62936602
Uterine cancer 10.70 10.45 15 545277 4718 62939012
Thiopurine methyltransferase decreased 10.64 10.45 14 545278 333 62943397
Eye swelling 10.63 10.45 143 545149 23775 62919955
Frequent bowel movements 10.63 10.45 266 545026 22756 62920974
Anger 10.62 10.45 63 545229 12393 62931337
Drug effective for unapproved indication 10.62 10.45 8 545284 3356 62940374
Skin test positive 10.61 10.45 21 545271 711 62943019
Incorrect product administration duration 10.60 10.45 57 545235 11489 62932241
Personality change 10.60 10.45 28 545264 6945 62936785
Myeloblast percentage decreased 10.60 10.45 6 545286 41 62943689
C-reactive protein increased 10.58 10.45 948 544344 93759 62849971
Carpal tunnel syndrome 10.55 10.45 121 545171 20696 62923034
Parotid gland enlargement 10.55 10.45 23 545269 835 62942895
Oesophageal candidiasis 10.54 10.45 84 545208 5579 62938151
Sarcoidosis 10.53 10.45 29 545263 7093 62936637
Pulmonary renal syndrome 10.49 10.45 16 545276 438 62943292
Restless legs syndrome 10.49 10.45 105 545187 18426 62925304
Gastrooesophageal reflux disease 10.48 10.45 956 544336 94683 62849047
Condition aggravated 10.46 10.45 3190 542102 399027 62544703
Swelling face 10.45 10.45 442 544850 63033 62880697

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 1063.29 11.04 2968 300115 125301 34528547
Drug ineffective 565.75 11.04 2051 301032 454700 34199148
Toxicity to various agents 552.36 11.04 554 302529 199808 34454040
Completed suicide 441.56 11.04 150 302933 98018 34555830
Drug abuse 337.42 11.04 222 302861 98874 34554974
Chronic kidney disease 321.33 11.04 934 302149 40276 34613572
Systemic infection 309.39 11.04 298 302785 4914 34648934
Hypomagnesaemia 298.91 11.04 615 302468 21236 34632612
Product prescribing error 259.67 11.04 598 302485 22329 34631519
Anaemia 255.84 11.04 3118 299965 230217 34423631
Haematochezia 209.32 11.04 879 302204 45655 34608193
Hypocalcaemia 174.57 11.04 535 302548 23754 34630094
Death 159.28 11.04 2462 300621 395587 34258261
Electrolyte imbalance 129.40 11.04 344 302739 14068 34639780
Product monitoring error 125.79 11.04 172 302911 4209 34649639
Dyspnoea 124.63 11.04 4204 298879 372578 34281270
Acute kidney injury 120.88 11.04 3479 299604 301509 34352339
End stage renal disease 116.00 11.04 245 302838 8616 34645232
Hepatic function abnormal 110.50 11.04 133 302950 44230 34609618
Off label use 105.41 11.04 2802 300281 416722 34237126
Intentional product misuse 105.08 11.04 145 302938 45466 34608382
Intentional overdose 103.50 11.04 136 302947 43538 34610310
Cholestasis 95.76 11.04 475 302608 26473 34627375
Overdose 95.42 11.04 435 302648 90624 34563224
Foetal exposure during pregnancy 93.02 11.04 116 302967 37985 34615863
Renal injury 92.31 11.04 259 302824 10936 34642912
Melaena 91.28 11.04 572 302511 34808 34619040
Hypokalaemia 88.75 11.04 832 302251 57382 34596466
Abdominal pain lower 87.59 11.04 245 302838 10326 34643522
Atrial fibrillation 86.99 11.04 1518 301565 120875 34532973
Drug resistance 86.92 11.04 59 303024 25868 34627980
Treatment failure 84.86 11.04 173 302910 46524 34607324
Syncope 79.91 11.04 1174 301909 90277 34563571
Haematemesis 78.46 11.04 459 302624 27252 34626596
Product dose omission issue 78.00 11.04 663 302420 119048 34534800
Oedema peripheral 77.41 11.04 1464 301619 118348 34535500
Dyspnoea at rest 70.02 11.04 122 302961 3706 34650142
Product use in unapproved indication 69.87 11.04 666 302417 116833 34537015
Agranulocytosis 68.37 11.04 396 302687 23425 34630423
Respiratory arrest 67.80 11.04 86 302997 27957 34625891
Abdominal pain 66.68 11.04 1874 301209 161744 34492104
Abdominal pain upper 64.11 11.04 922 302161 70568 34583280
Cardiac arrest 63.32 11.04 531 302552 95628 34558220
Premature baby 62.76 11.04 47 303036 19586 34634262
Neuropathy peripheral 62.71 11.04 443 302640 82820 34571028
Labelled drug-drug interaction medication error 62.36 11.04 276 302807 14663 34639185
Hepatitis cholestatic 61.77 11.04 180 302903 7767 34646081
Disease progression 61.56 11.04 619 302464 107458 34546390
Irritability 59.40 11.04 76 303007 24614 34629234
Normocytic anaemia 56.96 11.04 85 302998 2259 34651589
Diastolic dysfunction 56.26 11.04 149 302934 6078 34647770
Dyspnoea exertional 55.54 11.04 597 302486 42682 34611166
Erysipelas 55.21 11.04 127 302956 4736 34649112
Drug ineffective for unapproved indication 54.00 11.04 76 303007 23639 34630209
Blood loss anaemia 53.82 11.04 175 302908 8019 34645829
Febrile infection 53.47 11.04 80 303003 2131 34651717
Abnormal behaviour 52.99 11.04 84 302999 24885 34628963
Hypoparathyroidism 52.71 11.04 43 303040 562 34653286
Sedation 52.27 11.04 63 303020 20943 34632905
Right atrial hypertrophy 51.54 11.04 48 303035 757 34653091
Musculoskeletal pain 51.31 11.04 462 302621 31501 34622347
Tricuspid valve incompetence 50.77 11.04 193 302890 9567 34644281
Lower respiratory tract infection 50.32 11.04 126 302957 31511 34622337
Acute abdomen 49.10 11.04 72 303011 1883 34651965
Benign prostatic hyperplasia 49.03 11.04 252 302831 14243 34639605
Gastrooesophageal reflux disease 48.60 11.04 523 302560 37401 34616447
Rash 48.54 11.04 1516 301567 221236 34432612
Bronchial secretion retention 48.23 11.04 63 303020 1473 34652375
Feeling abnormal 47.82 11.04 336 302747 62899 34590949
Suicide attempt 47.74 11.04 176 302907 38940 34614908
Cytomegalovirus infection 47.32 11.04 97 302986 26038 34627810
Synovitis 47.16 11.04 32 303051 14034 34639814
Prostate cancer 46.70 11.04 181 302902 39468 34614380
Occult blood 46.62 11.04 47 303036 821 34653027
Therapy partial responder 46.22 11.04 13 303070 9603 34644245
Aortic valve stenosis 45.40 11.04 83 303000 2620 34651228
Urogenital haemorrhage 44.98 11.04 43 303040 702 34653146
Infective exacerbation of chronic obstructive airways disease 44.80 11.04 67 303016 1784 34652064
Therapeutic drug monitoring analysis not performed 44.75 11.04 38 303045 527 34653321
Rash maculo-papular 44.53 11.04 409 302674 28042 34625806
Bronchial wall thickening 44.34 11.04 57 303026 1311 34652537
Pallor 43.86 11.04 374 302709 25106 34628742
Gastrointestinal haemorrhage 43.75 11.04 1040 302043 87437 34566411
Immune reconstitution inflammatory syndrome 43.70 11.04 11 303072 8748 34645100
Cardio-respiratory arrest 43.62 11.04 290 302793 54983 34598865
Neutrophil count decreased 43.48 11.04 262 302821 50842 34603006
Pathogen resistance 43.44 11.04 14 303069 9468 34644380
Asthenia 42.74 11.04 2565 300518 242686 34411162
Agitation 42.42 11.04 307 302776 57092 34596756
Psychotic disorder 42.39 11.04 93 302990 24359 34629489
Cardiac failure 41.95 11.04 1062 302021 90186 34563662
Injection site pain 41.02 11.04 186 302897 38819 34615029
Aggression 40.86 11.04 186 302897 38778 34615070
Malaise 40.86 11.04 1263 301820 184562 34469286
Insomnia 40.82 11.04 644 302439 103263 34550585
Therapy non-responder 40.38 11.04 188 302895 38958 34614890
Platelet count decreased 40.27 11.04 763 302320 118954 34534894
Suicidal ideation 39.89 11.04 197 302886 40191 34613657
Type I hypersensitivity 39.09 11.04 53 303030 1286 34652562
Drug reaction with eosinophilia and systemic symptoms 38.98 11.04 448 302635 32564 34621284
Hypoparathyroidism secondary 37.95 11.04 21 303062 135 34653713
Seizure 37.87 11.04 660 302423 104197 34549651
Full blood count abnormal 37.57 11.04 284 302799 18384 34635464
Low birth weight baby 37.42 11.04 11 303072 7894 34645954
Myelosuppression 37.05 11.04 69 303014 19196 34634652
Dizziness 37.03 11.04 2280 300803 216241 34437607
Mucosal haemorrhage 36.76 11.04 57 303026 1568 34652280
Shock haemorrhagic 36.75 11.04 195 302888 11159 34642689
Exposure during pregnancy 36.23 11.04 16 303067 8918 34644930
Drug hypersensitivity 36.20 11.04 486 302597 80043 34573805
Gastritis 36.05 11.04 318 302765 21555 34632293
Therapeutic response decreased 35.70 11.04 132 302951 29181 34624667
Drug withdrawal syndrome 35.58 11.04 74 303009 19760 34634088
C-reactive protein increased 35.56 11.04 663 302420 53435 34600413
Visual acuity reduced 35.54 11.04 53 303030 16096 34637752
Haematoma 35.10 11.04 358 302725 25247 34628601
Mitral valve incompetence 34.51 11.04 235 302848 14708 34639140
Tachyarrhythmia 34.31 11.04 88 302995 3520 34650328
Urinary hesitation 33.84 11.04 75 303008 2727 34651121
Joint swelling 33.66 11.04 344 302739 59546 34594302
Leukopenia 33.59 11.04 747 302336 62109 34591739
Right ventricular hypertrophy 33.58 11.04 53 303030 1481 34652367
Bladder cancer 33.38 11.04 56 303027 16222 34637626
Gastrointestinal bacterial overgrowth 33.26 11.04 18 303065 110 34653738
Rectal haemorrhage 32.90 11.04 511 302572 39738 34614110
Hypertensive nephropathy 32.84 11.04 30 303053 461 34653387
Acute graft versus host disease 32.76 11.04 8 303075 6495 34647353
Adjustment disorder 32.75 11.04 46 303037 1155 34652693
Asthma 32.41 11.04 535 302548 42121 34611727
Eosinophilia 31.93 11.04 358 302725 25864 34627984
Congenital hiatus hernia 31.92 11.04 38 303045 806 34653042
Fluid intake reduced 31.87 11.04 87 302996 3614 34650234
Pulmonary function test abnormal 31.68 11.04 70 303013 2540 34651308
Electrocardiogram abnormal 31.44 11.04 161 302922 9086 34644762
Fracture 31.25 11.04 130 302953 6719 34647129
Serotonin syndrome 31.22 11.04 80 303003 19853 34633995
Nephrogenic anaemia 31.13 11.04 63 303020 2148 34651700
Obstruction 30.86 11.04 71 303012 2648 34651200
Interstitial lung disease 30.80 11.04 390 302693 64892 34588956
Cerebral infarction 30.65 11.04 128 302955 27327 34626521
Angina pectoris 30.32 11.04 410 302673 30953 34622895
Accidental exposure to product 30.18 11.04 40 303043 12762 34641086
Carotid arteriosclerosis 29.89 11.04 56 303027 1802 34652046
Colitis microscopic 29.87 11.04 64 303019 2273 34651575
Wrong technique in product usage process 29.82 11.04 186 302897 35800 34618048
Stomatitis 29.69 11.04 231 302852 42283 34611565
Post transplant lymphoproliferative disorder 29.27 11.04 10 303073 6518 34647330
Arrhythmia 28.65 11.04 453 302630 35355 34618493
Ventricular enlargement 28.65 11.04 32 303051 632 34653216
Extrapyramidal disorder 28.61 11.04 42 303041 12838 34641010
Intentional self-injury 28.59 11.04 47 303036 13724 34640124
Body temperature decreased 28.35 11.04 202 302881 12832 34641016
Hyperlipasaemia 28.24 11.04 28 303055 479 34653369
Hydrocholecystis 28.13 11.04 27 303056 443 34653405
Chest X-ray abnormal 28.05 11.04 93 302990 4305 34649543
Poisoning 28.01 11.04 39 303044 12187 34641661
Respiratory tract haemorrhage 27.97 11.04 44 303039 1226 34652622
Injection site erythema 27.95 11.04 60 303023 15839 34638009
Hypersensitivity 27.92 11.04 367 302716 60668 34593180
Incorrect route of product administration 27.82 11.04 54 303029 14791 34639057
Diverticulum intestinal 27.43 11.04 87 302996 3934 34649914
Upper gastrointestinal haemorrhage 27.36 11.04 340 302743 25178 34628670
Chronic graft versus host disease 27.31 11.04 3 303080 4370 34649478
Sleep disorder due to a general medical condition 26.95 11.04 103 302980 5118 34648730
Dysplastic naevus 26.90 11.04 27 303056 469 34653379
Blood pressure fluctuation 26.89 11.04 336 302747 24913 34628935
Aortic valve incompetence 26.89 11.04 112 302971 5792 34648056
Haematoma muscle 26.87 11.04 45 303038 1323 34652525
Thrombocytopenia 26.75 11.04 1632 301451 154615 34499233
Degenerative mitral valve disease 26.61 11.04 21 303062 261 34653587
Solar lentigo 26.38 11.04 28 303055 521 34653327
Withdrawal syndrome 26.33 11.04 42 303041 12413 34641435
Accidental overdose 26.33 11.04 88 302995 20052 34633796
Bronchiectasis 26.23 11.04 160 302923 9641 34644207
Injection site swelling 26.18 11.04 37 303046 11490 34642358
Therapeutic product effect decreased 26.06 11.04 185 302898 34558 34619290
Iron deficiency anaemia 26.01 11.04 166 302917 10163 34643685
Appendicitis 25.93 11.04 56 303027 14751 34639097
Hiatus hernia 25.91 11.04 133 302950 7512 34646336
Rhinitis perennial 25.91 11.04 22 303061 305 34653543
Urosepsis 25.91 11.04 195 302888 12604 34641244
Presyncope 25.90 11.04 266 302817 18793 34635055
Injection site haemorrhage 25.71 11.04 28 303055 9740 34644108
Lactic acidosis 25.63 11.04 434 302649 34338 34619510
Somnolence 25.43 11.04 751 302332 110365 34543483
Electrocardiogram Q wave abnormal 25.39 11.04 25 303058 424 34653424
Subileus 25.33 11.04 73 303010 3130 34650718
Oesophageal carcinoma 25.23 11.04 26 303057 9278 34644570
Dysuria 25.04 11.04 352 302731 26800 34627048
Tetanus 24.92 11.04 12 303071 55 34653793
No adverse event 24.91 11.04 108 302975 22819 34631029
Device leakage 24.79 11.04 13 303070 6562 34647286
Anaphylactic reaction 24.72 11.04 171 302912 32130 34621718
Renal cyst 24.69 11.04 149 302934 8944 34644904
Systolic dysfunction 24.67 11.04 65 303018 2643 34651205
Enthesopathy 24.60 11.04 5 303078 4608 34649240
Product use issue 24.41 11.04 393 302690 62823 34591025
Bronchopulmonary aspergillosis 24.40 11.04 57 303026 14602 34639246
Photodermatosis 24.06 11.04 27 303056 536 34653312
Blood phosphorus increased 24.02 11.04 19 303064 7702 34646146
Urticaria 24.01 11.04 388 302695 61989 34591859
Troponin increased 23.90 11.04 175 302908 11214 34642634
Subacute cutaneous lupus erythematosus 23.87 11.04 36 303047 966 34652882
Memory impairment 23.85 11.04 250 302833 43068 34610780
Hepatocellular injury 23.84 11.04 296 302787 21915 34631933
Blood pressure systolic increased 23.83 11.04 304 302779 22648 34631200
Vitamin B12 deficiency 23.74 11.04 83 303000 3948 34649900
Gastritis erosive 23.56 11.04 108 302975 5824 34648024
Gamma-glutamyltransferase increased 23.46 11.04 370 302713 28861 34624987
Occupational dermatitis 22.95 11.04 13 303070 88 34653760
Epileptic encephalopathy 22.94 11.04 17 303066 191 34653657
Product storage error 22.83 11.04 22 303061 8100 34645748
Flushing 22.71 11.04 176 302907 32244 34621604
Injection site bruising 22.61 11.04 25 303058 8638 34645210
Stress 22.56 11.04 162 302921 30185 34623663
Exercise tolerance decreased 22.43 11.04 97 302986 5101 34648747
Altered state of consciousness 22.41 11.04 112 302971 22781 34631067
Nightmare 22.35 11.04 58 303025 14333 34639515
Thrombotic microangiopathy 22.33 11.04 36 303047 10594 34643254
Ventricular arrhythmia 22.22 11.04 101 302982 5427 34648421
Gastrointestinal angiodysplasia 22.20 11.04 27 303056 586 34653262
Blindness 22.07 11.04 62 303021 14924 34638924
Lower gastrointestinal haemorrhage 22.04 11.04 149 302934 9303 34644545
Nicotine dependence 22.02 11.04 27 303056 591 34653257
Vertigo 21.94 11.04 327 302756 25209 34628639
Nasal polyps 21.71 11.04 59 303024 2444 34651404
Neuroleptic malignant syndrome 21.68 11.04 81 303002 17853 34635995
Syringe issue 21.65 11.04 11 303072 5653 34648195
Hallucination 21.64 11.04 315 302768 51183 34602665
Anger 21.60 11.04 44 303039 11840 34642008
Rebound acid hypersecretion 21.59 11.04 13 303070 100 34653748
Cardiotoxicity 21.55 11.04 11 303072 5637 34648211
Bronchial obstruction 21.52 11.04 45 303038 1571 34652277
Drug use disorder 21.42 11.04 5 303078 4186 34649662
Treatment noncompliance 21.38 11.04 149 302934 27951 34625897
Liver disorder 21.34 11.04 183 302900 32814 34621034
Alanine aminotransferase abnormal 21.34 11.04 7 303076 4681 34649167
Biliary cirrhosis 21.28 11.04 13 303070 103 34653745
Microcytic anaemia 21.25 11.04 57 303026 2343 34651505
Serum ferritin decreased 21.19 11.04 29 303054 710 34653138
Fear of disease 21.06 11.04 19 303064 287 34653561
Hepatojugular reflux 21.00 11.04 26 303057 575 34653273
Haematotoxicity 21.00 11.04 24 303059 8170 34645678
White blood cell count decreased 20.87 11.04 649 302434 94796 34559052
Chest injury 20.83 11.04 44 303039 1547 34652301
Lethargy 20.78 11.04 242 302841 40880 34612968
Stenosis 20.77 11.04 42 303041 1431 34652417
Serum ferritin abnormal 20.67 11.04 17 303066 225 34653623
Glomerular filtration rate decreased 20.62 11.04 187 302896 12774 34641074
Ventricular hypokinesia 20.53 11.04 99 302984 5453 34648395
Cough 20.51 11.04 1539 301544 148601 34505247
Dehydration 20.49 11.04 1348 301735 128621 34525227
Mood swings 20.41 11.04 23 303060 7878 34645970
Victim of child abuse 20.25 11.04 32 303051 895 34652953
Reversible airways obstruction 20.13 11.04 23 303060 466 34653382
Tendonitis 20.11 11.04 30 303053 9110 34644738
Blood pressure diastolic abnormal 20.10 11.04 89 302994 4729 34649119
Acute graft versus host disease in skin 20.03 11.04 10 303073 5191 34648657
Cytomegalovirus viraemia 19.88 11.04 21 303062 7409 34646439
Hyponatraemia 19.65 11.04 891 302192 81800 34572048
Drug intolerance 19.60 11.04 381 302702 59189 34594659
Therapeutic product effect incomplete 19.58 11.04 314 302769 50227 34603621
Autoimmune colitis 19.44 11.04 33 303050 981 34652867
Cardiac aneurysm 19.42 11.04 32 303051 928 34652920
Apparent death 19.33 11.04 4 303079 3640 34650208
Weight decreased 19.28 11.04 1777 301306 174524 34479324
Fall 19.28 11.04 2025 301058 200860 34452988
SARS-CoV-2 antibody test positive 19.27 11.04 21 303062 403 34653445
Pulmonary valve disease 19.21 11.04 19 303064 324 34653524
Foetal malformation 19.21 11.04 13 303070 125 34653723
Cold sweat 19.02 11.04 150 302933 9837 34644011
Sexual dysfunction 19.00 11.04 16 303067 6287 34647561
Duodenogastric reflux 18.78 11.04 5 303078 0 34653848
Drug dependence 18.63 11.04 128 302955 24089 34629759
Pancreatitis acute 18.52 11.04 345 302738 27796 34626052
Abdominal wall haemorrhage 18.43 11.04 22 303061 468 34653380
Discontinued product administered 18.41 11.04 7 303076 15 34653833
Rectal prolapse 18.36 11.04 22 303061 470 34653378
Haematuria 18.31 11.04 566 302517 49500 34604348
Anastomotic infection 18.29 11.04 12 303071 109 34653739
Disinhibition 18.27 11.04 3 303080 3223 34650625
Pericardial disease 18.25 11.04 21 303062 429 34653419
Hyperreflexia 18.12 11.04 3 303080 3203 34650645
Hypercholesterolaemia 18.02 11.04 134 302949 8628 34645220
Depression 18.02 11.04 674 302409 96424 34557424
Erectile dysfunction 17.97 11.04 105 302978 20532 34633316
Disseminated intravascular coagulation 17.95 11.04 113 302970 21703 34632145
Productive cough 17.92 11.04 442 302641 37371 34616477
Substance abuse 17.88 11.04 24 303059 7617 34646231
Mean cell haemoglobin decreased 17.68 11.04 43 303040 1663 34652185
Left ventricular hypertrophy 17.68 11.04 126 302957 8004 34645844
Cellulitis 17.62 11.04 338 302745 52613 34601235
Miosis 17.59 11.04 35 303048 9500 34644348
Aortic dilatation 17.49 11.04 38 303045 1363 34652485
Underdose 17.47 11.04 61 303022 13719 34640129
Mania 17.47 11.04 35 303048 9476 34644372
Phalangeal hypoplasia 17.38 11.04 10 303073 70 34653778
Tachypnoea 17.36 11.04 239 302844 18113 34635735
Tetany 17.34 11.04 28 303055 798 34653050
Osteochondrosis 17.29 11.04 33 303050 1077 34652771
Cerebellar ischaemia 17.26 11.04 12 303071 121 34653727
Status epilepticus 17.26 11.04 54 303029 12560 34641288
Pancreatic enzyme abnormality 17.26 11.04 10 303073 71 34653777
Epidural lipomatosis 17.24 11.04 32 303051 1022 34652826
Cachexia 17.18 11.04 114 302969 7072 34646776
Alopecia 17.16 11.04 132 302951 24223 34629625
Psoriatic arthropathy 17.10 11.04 101 302982 19697 34634151
Varicose vein 17.05 11.04 37 303046 1326 34652522
Antineutrophil cytoplasmic antibody positive 17.04 11.04 27 303056 757 34653091
Gravitational oedema 17.01 11.04 25 303058 655 34653193
Impaired work ability 17.01 11.04 21 303062 6909 34646939
Injection site reaction 17.00 11.04 57 303026 12976 34640872
Drug eruption 16.92 11.04 102 302981 19796 34634052
Sickle cell anaemia with crisis 16.85 11.04 7 303076 4046 34649802
Drug screen false positive 16.83 11.04 26 303057 713 34653135
Mucormycosis 16.81 11.04 16 303067 5926 34647922
Hyperparathyroidism secondary 16.76 11.04 40 303043 1528 34652320
Chronic kidney disease-mineral and bone disorder 16.75 11.04 19 303064 382 34653466
Infusion site haematoma 16.74 11.04 6 303077 10 34653838
Blood pressure increased 16.73 11.04 929 302154 87173 34566675
Immature granulocyte count increased 16.71 11.04 12 303071 128 34653720
Hyperkinesia 16.68 11.04 43 303040 1725 34652123
Abnormal faeces 16.68 11.04 65 303018 3260 34650588
Bicytopenia 16.65 11.04 52 303031 2332 34651516
Transient aphasia 16.59 11.04 19 303064 386 34653462
Cardiac failure congestive 16.59 11.04 573 302510 82697 34571151
Shock 16.59 11.04 132 302951 24047 34629801
Dermatitis infected 16.58 11.04 11 303072 102 34653746
Flatulence 16.51 11.04 267 302816 20931 34632917
Peripheral arterial occlusive disease 16.43 11.04 97 302986 5777 34648071
Obstructive airways disorder 16.42 11.04 206 302877 15288 34638560
Mean cell haemoglobin concentration 16.39 11.04 8 303075 38 34653810
Duodenitis 16.37 11.04 84 302999 4744 34649104
Vision blurred 16.35 11.04 290 302793 45673 34608175
Paranoia 16.28 11.04 52 303031 12016 34641832
Osteonecrosis 16.26 11.04 70 303013 14820 34639028
Drug abuser 16.16 11.04 7 303076 3947 34649901
Graft versus host disease 16.11 11.04 43 303040 10526 34643322
N-terminal prohormone brain natriuretic peptide increased 16.08 11.04 56 303027 2659 34651189
Gastrointestinal pain 15.98 11.04 67 303016 3475 34650373
Jugular vein distension 15.97 11.04 24 303059 642 34653206
Exposure to toxic agent 15.85 11.04 6 303077 3669 34650179
Jaundice 15.81 11.04 375 302708 31507 34622341
Procalcitonin abnormal 15.78 11.04 18 303065 364 34653484
Base excess decreased 15.70 11.04 14 303069 208 34653640
Alveolar lung disease 15.63 11.04 18 303065 368 34653480
Device dependence 15.61 11.04 8 303075 43 34653805
Abnormal dreams 15.60 11.04 26 303057 7552 34646296
Colitis ulcerative 15.57 11.04 215 302868 16305 34637543
Paresis 15.56 11.04 48 303035 2138 34651710
Bradyarrhythmia 15.49 11.04 48 303035 2143 34651705
Lymph node calcification 15.41 11.04 12 303071 146 34653702
Intraductal papillary mucinous neoplasm 15.35 11.04 21 303062 514 34653334
Renal cyst haemorrhage 15.28 11.04 23 303060 616 34653232
Saliva altered 15.27 11.04 13 303070 181 34653667
Product quality issue 15.19 11.04 86 302997 16949 34636899
Pruritus allergic 15.16 11.04 15 303068 256 34653592
Activated partial thromboplastin time shortened 15.14 11.04 20 303063 473 34653375
Anxiety 15.11 11.04 706 302377 98722 34555126
Symmetrical drug-related intertriginous and flexural exanthema 15.05 11.04 17 303066 340 34653508
Pneumonia aspiration 15.03 11.04 264 302819 41639 34612209
Microvillous inclusion disease 14.92 11.04 13 303070 187 34653661
Procalcitonin increased 14.92 11.04 41 303042 1710 34652138
Pulpitis dental 14.87 11.04 22 303061 580 34653268
Eosinophilic pneumonia 14.85 11.04 65 303018 3436 34650412
Bone marrow failure 14.84 11.04 172 302911 29081 34624767
Physical examination abnormal 14.81 11.04 16 303067 304 34653544
Sinusitis 14.80 11.04 261 302822 41141 34612707
Akathisia 14.76 11.04 30 303053 8079 34645769
Peripheral venous disease 14.68 11.04 54 303029 2634 34651214
Tinnitus 14.66 11.04 108 302975 20010 34633838
Rhythm idioventricular 14.65 11.04 16 303067 308 34653540
Nocardiosis 14.62 11.04 8 303075 3943 34649905
Hypertrophy 14.62 11.04 19 303064 442 34653406
Thrombophlebitis 14.58 11.04 61 303022 3161 34650687
Tuberculosis 14.56 11.04 33 303050 8544 34645304
Injection site phlebitis 14.55 11.04 7 303076 32 34653816
Unintentional medical device removal 14.52 11.04 3 303080 2733 34651115
Polyneuropathy 14.50 11.04 195 302888 14701 34639147
Uveitis 14.48 11.04 27 303056 7508 34646340
Chondrocalcinosis 14.47 11.04 18 303065 400 34653448
Atrial enlargement 14.41 11.04 23 303060 649 34653199
Atheroembolism 14.40 11.04 16 303067 314 34653534
Bundle branch block left 14.39 11.04 95 302988 5884 34647964
Clostridium difficile infection 14.34 11.04 237 302846 18661 34635187
Malignant melanoma in situ 14.26 11.04 40 303043 1688 34652160
Anaemia of malignant disease 14.20 11.04 19 303064 455 34653393
Multiple sclerosis relapse 14.18 11.04 62 303021 13071 34640777
Arthropathy 14.12 11.04 157 302926 26750 34627098
Wound haemorrhage 14.12 11.04 45 303038 2040 34651808
Benign gastrointestinal neoplasm 14.12 11.04 11 303072 134 34653714
Carotid artery stenosis 14.11 11.04 83 303000 4936 34648912
Mastitis 14.10 11.04 12 303071 167 34653681
COVID-19 pneumonia 14.08 11.04 216 302867 16751 34637097
Headache 14.02 11.04 1524 301559 199111 34454737
Vena cava injury 14.01 11.04 16 303067 324 34653524
Diplopia 13.98 11.04 87 302996 16756 34637092
Mood altered 13.96 11.04 36 303047 8916 34644932
Rales 13.94 11.04 139 302944 9744 34644104
Pulmonary valve incompetence 13.92 11.04 27 303056 892 34652956
Pulmonary vascular disorder 13.86 11.04 23 303060 671 34653177
Mydriasis 13.84 11.04 26 303057 7211 34646637
Dependence on oxygen therapy 13.81 11.04 13 303070 208 34653640
Faecal calprotectin increased 13.81 11.04 51 303032 2493 34651355
Periarthritis calcarea 13.70 11.04 9 303074 82 34653766
Cognitive disorder 13.68 11.04 171 302912 28522 34625326
Left ventricular enlargement 13.66 11.04 23 303060 679 34653169
Migraine 13.63 11.04 92 302991 17386 34636462
Chronic obstructive pulmonary disease 13.63 11.04 536 302547 48382 34605466
Inferior vena cava dilatation 13.61 11.04 24 303059 736 34653112
C-reactive protein abnormal 13.61 11.04 35 303048 8675 34645173
Heart rate decreased 13.56 11.04 366 302717 31379 34622469
Vascular purpura 13.56 11.04 40 303043 1738 34652110
Miller Fisher syndrome 13.52 11.04 10 303073 112 34653736
Intestinal angioedema 13.51 11.04 13 303070 214 34653634
Acute coronary syndrome 13.47 11.04 178 302905 13367 34640481
Anaemia macrocytic 13.47 11.04 57 303026 2969 34650879
Breath sounds abnormal 13.46 11.04 104 302979 6777 34647071
Articular calcification 13.43 11.04 9 303074 85 34653763
Puncture site haematoma 13.35 11.04 11 303072 146 34653702
Internal fixation of fracture 13.35 11.04 9 303074 86 34653762
Device malfunction 13.30 11.04 46 303037 10375 34643473
Nuchal rigidity 13.24 11.04 19 303064 487 34653361
Perihepatic abscess 13.23 11.04 10 303073 116 34653732
Adverse drug reaction 13.20 11.04 177 302906 29165 34624683
Electrocardiogram QT prolonged 13.17 11.04 456 302627 40496 34613352
Actinic keratosis 13.15 11.04 76 303007 4491 34649357
Faeces pale 13.11 11.04 34 303049 1369 34652479
Activated partial thromboplastin time prolonged 13.10 11.04 124 302959 8571 34645277
Granulocytopenia 13.09 11.04 23 303060 6544 34647304
Cryptitis 13.08 11.04 13 303070 223 34653625
Urinary straining 13.06 11.04 5 303078 11 34653837
Graft versus host disease in skin 13.06 11.04 9 303074 3916 34649932
Blood thyroid stimulating hormone increased 13.04 11.04 72 303011 4183 34649665
Abdominal discomfort 13.04 11.04 407 302676 59428 34594420
Myelocyte count increased 13.02 11.04 16 303067 351 34653497
Plasma cell myeloma 13.00 11.04 466 302617 41571 34612277
Foetal growth restriction 12.97 11.04 10 303073 4107 34649741
Phlebitis infective 12.96 11.04 10 303073 120 34653728
Upper motor neurone lesion 12.96 11.04 10 303073 120 34653728
Myoglobin blood increased 12.93 11.04 5 303078 3018 34650830
Occupational exposure to air contaminants 12.93 11.04 11 303072 153 34653695
Nasal oedema 12.92 11.04 16 303067 354 34653494
Hepatitis B reactivation 12.85 11.04 9 303074 3882 34649966
Taste disorder 12.83 11.04 106 302977 7049 34646799
Lymph nodes scan abnormal 12.81 11.04 4 303079 3 34653845
Dermatosis 12.79 11.04 15 303068 313 34653535
Vascular compression 12.71 11.04 16 303067 360 34653488
Metastatic malignant melanoma 12.70 11.04 43 303040 2012 34651836
Vascular anastomotic haemorrhage 12.67 11.04 14 303069 273 34653575
Angioedema 12.61 11.04 238 302845 37136 34616712
Lichenoid keratosis 12.56 11.04 49 303034 2459 34651389
Injection site mass 12.50 11.04 24 303059 6602 34647246
Epstein-Barr virus infection 12.42 11.04 30 303053 7598 34646250
Xyphoid retraction 12.42 11.04 11 303072 162 34653686
Chest pain 12.42 11.04 1268 301815 125494 34528354
Arthritis 12.39 11.04 194 302889 31152 34622696
Visual impairment 12.38 11.04 227 302856 35575 34618273
Arteriosclerotic gangrene 12.35 11.04 8 303075 71 34653777
Dysmorphism 12.26 11.04 6 303077 3150 34650698
Hypertransaminasaemia 12.26 11.04 87 302996 5519 34648329
Cytomegalovirus chorioretinitis 12.25 11.04 8 303075 3581 34650267
Leptospirosis 12.21 11.04 6 303077 29 34653819
Hypogammaglobulinaemia 12.17 11.04 31 303052 7709 34646139
Vitamin D decreased 12.15 11.04 61 303022 3415 34650433
Renal cancer 12.15 11.04 31 303052 7704 34646144
Eye irritation 12.11 11.04 30 303053 7531 34646317
Tobacco abuse 12.04 11.04 17 303066 429 34653419
Osteoporosis 11.99 11.04 165 302918 12503 34641345
Leptotrichia infection 11.99 11.04 8 303075 75 34653773
Stoma site discharge 11.96 11.04 30 303053 1183 34652665
Pulmonary sepsis 11.95 11.04 45 303038 2220 34651628
Acute generalised exanthematous pustulosis 11.94 11.04 100 302983 6676 34647172
Cardiac ablation 11.90 11.04 28 303055 1060 34652788
Haemorrhoids 11.89 11.04 185 302898 14390 34639458
Asphyxia 11.84 11.04 26 303057 6809 34647039
Bile duct stone 11.82 11.04 49 303034 2528 34651320
Confabulation 11.82 11.04 10 303073 138 34653710
Ocular hyperaemia 11.81 11.04 55 303028 11397 34642451
Hepatitis 11.80 11.04 281 302802 23623 34630225
Depressive symptom 11.78 11.04 5 303078 2854 34650994
Eye pruritus 11.77 11.04 30 303053 7459 34646389
Forced expiratory volume decreased 11.76 11.04 57 303026 3146 34650702
Soft tissue haemorrhage 11.76 11.04 10 303073 139 34653709
Cardiac discomfort 11.75 11.04 20 303063 596 34653252
Tumour pain 11.74 11.04 28 303055 1069 34652779
Vascular access site occlusion 11.72 11.04 7 303076 53 34653795
Product administered to patient of inappropriate age 11.70 11.04 7 303076 3284 34650564
Delusion 11.70 11.04 63 303020 12572 34641276
Pancreatic duct stenosis 11.68 11.04 11 303072 176 34653672
Granulomatous dermatitis 11.67 11.04 13 303070 256 34653592
Adverse event 11.63 11.04 106 302977 18771 34635077
Fatigue 11.60 11.04 3489 299594 367164 34286684
Painful respiration 11.60 11.04 30 303053 1206 34652642
Helicobacter gastritis 11.60 11.04 30 303053 1206 34652642
Atypical pneumonia 11.59 11.04 59 303024 3321 34650527
Pneumonia cytomegaloviral 11.57 11.04 6 303077 3048 34650800
Blood pressure systolic abnormal 11.56 11.04 66 303017 3882 34649966
Multiple organ dysfunction syndrome 11.56 11.04 544 302539 76022 34577826
Perineal cyst 11.55 11.04 13 303070 259 34653589
Dermatitis exfoliative generalised 11.54 11.04 63 303020 3644 34650204
Heart rate irregular 11.54 11.04 197 302886 15610 34638238
Blood cholesterol increased 11.53 11.04 118 302965 20425 34633423
Eye injury 11.53 11.04 24 303059 835 34653013
Polypectomy 11.53 11.04 19 303064 551 34653297
Arteriovenous fistula 11.51 11.04 28 303055 1083 34652765
Dysentery 11.51 11.04 15 303068 350 34653498
Pneumobilia 11.40 11.04 8 303075 82 34653766
Organic brain syndrome 11.40 11.04 13 303070 263 34653585
Mean cell volume increased 11.35 11.04 56 303027 3113 34650735
Influenza virus test positive 11.33 11.04 9 303074 113 34653735
Neoplasm malignant 11.31 11.04 114 302969 19791 34634057
Cardiovascular somatic symptom disorder 11.31 11.04 6 303077 35 34653813
Peripheral paralysis 11.31 11.04 6 303077 35 34653813
Hypoaesthesia 11.28 11.04 427 302656 61017 34592831
Hypotension 11.28 11.04 2133 300950 219516 34434332
Dyskinesia 11.28 11.04 132 302951 22281 34631567
Neuritis 11.28 11.04 25 303058 909 34652939
Band neutrophil count decreased 11.27 11.04 3 303080 0 34653848
Bladder diverticulitis 11.27 11.04 3 303080 0 34653848
Spinal cord herniation 11.27 11.04 3 303080 0 34653848
Fibrin D dimer 11.27 11.04 3 303080 0 34653848
Neonatal respiratory distress syndrome 11.25 11.04 11 303072 4023 34649825
Ventricular fibrillation 11.24 11.04 136 302947 22818 34631030
Mental status changes 11.21 11.04 248 302835 37835 34616013
Hyperkalaemia 11.16 11.04 721 302362 68668 34585180
Meralgia paraesthetica 11.14 11.04 10 303073 150 34653698
Bone erosion 11.14 11.04 11 303072 4004 34649844
Hyperalbuminaemia 11.10 11.04 5 303078 19 34653829
Obesity 11.10 11.04 165 302918 12713 34641135
Cytomegalovirus infection reactivation 11.07 11.04 17 303066 5101 34648747
Embedded device 11.06 11.04 14 303069 317 34653531
Pulmonary tuberculosis 11.06 11.04 15 303068 4739 34649109

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
General physical health deterioration 1837.92 10.07 5976 698582 269262 78770568
Toxicity to various agents 1201.98 10.07 1172 703386 420368 78619462
Completed suicide 1068.52 10.07 417 704141 245350 78794480
Drug ineffective 685.87 10.07 6186 698372 1074727 77965103
Product prescribing error 528.10 10.07 1201 703357 43612 78996218
Haematochezia 521.60 10.07 1833 702725 85812 78954018
Drug abuse 490.41 10.07 429 704129 162262 78877568
Systemic infection 460.21 10.07 497 704061 9255 79030575
Anaemia 449.76 10.07 5950 698608 439065 78600765
Hypomagnesaemia 417.19 10.07 1129 703429 45782 78994048
Chronic kidney disease 338.59 10.07 1318 703240 64836 78974994
Intentional overdose 314.91 10.07 283 704275 105677 78934153
Death 257.00 10.07 3494 701064 563020 78476810
Hypocalcaemia 253.30 10.07 992 703566 48932 78990898
Dyspnoea 232.36 10.07 9512 695046 847513 78192317
Product monitoring error 230.49 10.07 336 704222 8570 79031260
Abdominal pain upper 202.91 10.07 2937 701621 220882 78818948
Off label use 186.07 10.07 6360 698198 900855 78138975
Abdominal pain 185.85 10.07 4630 699928 384939 78654891
Labelled drug-drug interaction medication error 184.42 10.07 601 703957 27049 79012781
Hepatic function abnormal 183.76 10.07 225 704333 72882 78966948
Acute kidney injury 182.57 10.07 5938 698620 513466 78526364
Exposure during pregnancy 180.38 10.07 390 704168 100742 78939088
Overdose 180.22 10.07 925 703633 183281 78856549
Injection site erythema 177.90 10.07 259 704299 77938 78961892
Drug resistance 176.13 10.07 76 704482 42137 78997693
Injection site pain 173.87 10.07 577 703981 129261 78910569
Haematemesis 167.89 10.07 908 703650 51356 78988474
Device expulsion 167.35 10.07 17 704541 25844 79013986
Melaena 166.86 10.07 1014 703544 59876 78979954
Electrolyte imbalance 165.97 10.07 625 703933 30256 79009574
Hypokalaemia 162.89 10.07 1968 702590 142072 78897758
Muscle injury 162.35 10.07 853 703705 47708 78992122
Irritable bowel syndrome 159.61 10.07 1019 703539 61222 78978608
Folliculitis 157.99 10.07 932 703626 54448 78985382
Asthenia 154.07 10.07 5747 698811 505942 78533888
Injection site reaction 153.75 10.07 154 704404 54631 78985199
Hyponatraemia 150.67 10.07 2307 702251 175541 78864289
Product dose omission issue 150.30 10.07 1429 703129 246108 78793722
Respiratory arrest 149.03 10.07 173 704385 57377 78982453
Agranulocytosis 145.09 10.07 783 703775 44247 78995583
Intentional product misuse 142.30 10.07 402 704156 94763 78945067
Sleep disorder due to general medical condition, insomnia type 136.72 10.07 752 703806 42804 78997026
Cardio-respiratory arrest 133.37 10.07 500 704058 108010 78931820
Cholestasis 129.24 10.07 846 703712 51263 78988567
Impaired healing 126.42 10.07 1257 703301 86398 78953432
Sedation 125.96 10.07 164 704394 51731 78988099
Wrong technique in product usage process 125.12 10.07 293 704265 73582 78966248
Neuropathy peripheral 123.72 10.07 736 703822 140569 78899261
Myelosuppression 116.87 10.07 110 704448 40186 78999644
Suicide attempt 116.27 10.07 361 704197 82571 78957259
Product use in unapproved indication 112.13 10.07 1547 703011 248812 78791018
End stage renal disease 109.51 10.07 295 704263 11925 79027905
Injection site swelling 109.28 10.07 154 704404 46978 78992852
Disease progression 108.61 10.07 1072 703486 183290 78856540
Abdominal pain lower 108.11 10.07 561 703997 31221 79008609
Cardiac arrest 106.33 10.07 989 703569 171107 78868723
Drug hypersensitivity 104.78 10.07 1934 702624 296982 78742848
Neutrophil count decreased 101.05 10.07 456 704102 93503 78946327
Eosinophilia 101.02 10.07 717 703841 44628 78995202
Suicidal ideation 100.30 10.07 342 704216 75998 78963832
Subacute cutaneous lupus erythematosus 98.98 10.07 139 704419 3422 79036408
Abortion spontaneous 97.38 10.07 71 704487 29436 79010394
Atrial fibrillation 95.69 10.07 2357 702201 195529 78844301
Therapeutic drug monitoring analysis not performed 93.69 10.07 100 704458 1836 79037994
Oedema peripheral 93.00 10.07 2902 701656 249386 78790444
Accidental exposure to product 91.43 10.07 85 704473 31237 79008593
Blood loss anaemia 87.74 10.07 319 704239 15179 79024651
Treatment failure 87.26 10.07 1024 703534 169462 78870368
Injection site pruritus 86.74 10.07 150 704408 42133 78997697
Gastrointestinal haemorrhage 84.30 10.07 1801 702757 145918 78893912
Orthostatic intolerance 83.76 10.07 94 704464 1830 79038000
Hepatitis cholestatic 82.59 10.07 290 704268 13562 79026268
Musculoskeletal pain 82.16 10.07 1316 703242 101038 78938792
White blood cell count decreased 80.54 10.07 1174 703384 187114 78852716
Drug ineffective for unapproved indication 79.15 10.07 213 704345 51025 78988805
Syncope 78.72 10.07 2110 702448 177339 78862491
Platelet count decreased 78.38 10.07 1228 703330 193436 78846394
Leukopenia 78.00 10.07 1455 703103 115058 78924772
Pallor 77.12 10.07 728 703830 49334 78990496
Drug reaction with eosinophilia and systemic symptoms 75.76 10.07 885 703673 63359 78976471
Injection site bruising 75.71 10.07 155 704403 40847 78998983
Seizure 75.10 10.07 1194 703364 187640 78852190
Abnormal behaviour 74.90 10.07 129 704429 36292 79003538
Malaise 74.00 10.07 3555 701003 486314 78553516
Irritability 73.90 10.07 158 704400 40986 78998844
Anaphylactic reaction 72.84 10.07 437 704121 83306 78956524
Therapeutic response decreased 72.75 10.07 323 704235 66530 78973300
Feeling abnormal 72.57 10.07 980 703578 158219 78881611
Sedation complication 72.39 10.07 24 704534 15645 79024185
Night sweats 71.71 10.07 740 703818 51355 78988475
Acute abdomen 70.74 10.07 111 704447 3026 79036804
Helicobacter infection 70.49 10.07 933 703625 68771 78971059
Dyspnoea exertional 69.68 10.07 1119 703439 85954 78953876
Febrile infection 69.43 10.07 114 704444 3232 79036598
Intentional self-injury 67.42 10.07 114 704444 32305 79007525
Renal injury 67.00 10.07 312 704246 16615 79023215
Post transplant lymphoproliferative disorder 65.87 10.07 11 704547 11453 79028377
Cytomegalovirus infection 65.32 10.07 178 704380 42466 78997364
Cellulitis 64.26 10.07 634 703924 108426 78931404
Hypoparathyroidism secondary 64.10 10.07 34 704524 194 79039636
Injection site haemorrhage 63.68 10.07 92 704466 27778 79012052
Enthesopathy 62.71 10.07 13 704545 11595 79028235
Premature delivery 62.43 10.07 69 704489 23398 79016432
Drug dependence 61.83 10.07 171 704387 40598 78999232
Therapeutic product effect incomplete 61.67 10.07 880 703678 140765 78899065
Duodenal ulcer perforation 61.15 10.07 872 703686 65339 78974491
Serotonin syndrome 60.31 10.07 200 704358 44827 78995003
Somnolence 60.30 10.07 1628 702930 237353 78802477
Cachexia 59.29 10.07 224 704334 10859 79028971
Blister 59.19 10.07 1428 703130 118048 78921782
Ill-defined disorder 59.02 10.07 863 703695 65012 78974818
Angina pectoris 58.51 10.07 707 703851 51025 78988805
Pathogen resistance 57.98 10.07 27 704531 14315 79025515
Diastolic dysfunction 57.42 10.07 218 704340 10593 79029237
Gastritis 57.41 10.07 663 703895 47330 78992500
Therapy partial responder 57.23 10.07 42 704516 17355 79022475
Poisoning 57.18 10.07 84 704474 25188 79014642
Asthma 57.10 10.07 1581 702977 133514 78906316
Maternal exposure during pregnancy 57.10 10.07 855 703703 135683 78904147
Haematoma 56.73 10.07 708 703850 51487 78988343
Flushing 55.47 10.07 505 704053 87763 78952067
Muscle spasticity 55.29 10.07 352 704206 21123 79018707
Mydriasis 54.98 10.07 45 704513 17598 79022232
Tubulointerstitial nephritis 54.47 10.07 547 704011 37688 79002142
Gastrointestinal disorder 54.45 10.07 1440 703118 120765 78919065
Prostate cancer 53.91 10.07 135 704423 33133 79006697
Hypoparathyroidism 53.64 10.07 57 704501 1041 79038789
Unintentional medical device removal 52.80 10.07 4 704554 7708 79032122
Rheumatoid arthritis 52.25 10.07 2297 702261 206173 78833657
Acute graft versus host disease 51.70 10.07 13 704545 10154 79029676
Dehydration 50.88 10.07 2681 701877 245506 78794324
Depression 50.81 10.07 1492 703066 215298 78824532
No adverse event 50.64 10.07 164 704394 37028 79002802
Fracture 50.48 10.07 348 704210 21453 79018377
Colitis ulcerative 49.96 10.07 498 704060 34244 79005586
Device difficult to use 49.93 10.07 28 704530 13357 79026473
Tachyarrhythmia 49.77 10.07 155 704403 6807 79033023
Multiple-drug resistance 49.41 10.07 9 704549 8799 79031031
Lower respiratory tract infection 49.05 10.07 1492 703066 127728 78912102
Coma 49.01 10.07 611 703947 100038 78939792
Right atrial hypertrophy 48.67 10.07 46 704512 725 79039105
Aortic valve stenosis 48.65 10.07 129 704429 5165 79034665
Dysuria 48.64 10.07 675 703883 50276 78989554
Product storage error 48.59 10.07 43 704515 16183 79023647
Bladder cancer 48.11 10.07 61 704497 19465 79020365
Drug intolerance 47.61 10.07 1879 702679 262240 78777590
Benign prostatic hyperplasia 47.41 10.07 216 704342 11396 79028434
Breast cancer stage I 47.25 10.07 3 704555 6697 79033133
Dyspnoea at rest 47.15 10.07 157 704401 7145 79032685
Rash maculo-papular 46.88 10.07 726 703832 55352 78984478
Confusional state 46.52 10.07 3335 701223 314662 78725168
Body temperature decreased 46.34 10.07 461 704097 31684 79008146
Drug use disorder 46.10 10.07 10 704548 8641 79031189
Blood pressure systolic increased 45.33 10.07 838 703720 66148 78973682
Neuroleptic malignant syndrome 45.31 10.07 111 704447 27448 79012382
Shock haemorrhagic 45.14 10.07 318 704240 19742 79020088
Weight increased 45.13 10.07 2935 701623 274451 78765379
Lung diffusion test abnormal 45.01 10.07 33 704525 357 79039473
Fluid intake reduced 44.96 10.07 140 704418 6148 79033682
Cardiac failure 44.94 10.07 1733 702825 153109 78886721
Urogenital haemorrhage 44.71 10.07 49 704509 928 79038902
Device issue 44.71 10.07 109 704449 26999 79012831
Drug withdrawal syndrome 44.61 10.07 157 704401 34561 79005269
Psychotic disorder 44.46 10.07 201 704357 41201 78998629
Aggression 44.27 10.07 266 704292 50692 78989138
Caesarean section 44.25 10.07 28 704530 12507 79027323
Agitation 43.57 10.07 619 703939 99096 78940734
Shock 43.50 10.07 217 704341 43331 78996499
Tricuspid valve incompetence 43.50 10.07 311 704247 19401 79020429
Device use error 42.66 10.07 6 704552 7095 79032735
Vision blurred 42.61 10.07 668 703890 105230 78934600
Extrapyramidal disorder 42.49 10.07 85 704473 22594 79017236
Peripheral swelling 42.47 10.07 2845 701713 266772 78773058
Obstructive airways disorder 42.40 10.07 445 704113 31014 79008816
Exposure to toxic agent 42.36 10.07 14 704544 9144 79030686
Thrombocytopenia 42.13 10.07 2801 701757 262458 78777372
Iron deficiency anaemia 41.90 10.07 378 704180 25294 79014536
Breath sounds abnormal 41.77 10.07 263 704295 15721 79024109
Therapy non-responder 41.76 10.07 569 703989 91736 78948094
Hypertensive nephropathy 41.53 10.07 48 704510 966 79038864
Breast cancer female 41.29 10.07 25 704533 11436 79028394
Normocytic anaemia 41.21 10.07 105 704453 4102 79035728
Drug eruption 41.04 10.07 224 704334 43711 78996119
Cytomegalovirus viraemia 40.83 10.07 32 704526 12789 79027041
Erysipelas 40.77 10.07 197 704361 10653 79029177
Upper gastrointestinal haemorrhage 40.64 10.07 551 704007 40829 78999001
Pneumonia aspiration 40.41 10.07 387 704171 66580 78973250
Injection site warmth 39.99 10.07 43 704515 14764 79025066
Pre-eclampsia 39.92 10.07 7 704551 7034 79032796
Hypoaesthesia 39.88 10.07 1243 703315 178109 78861721
Ear pain 39.73 10.07 455 704103 32414 79007416
Balance disorder 39.64 10.07 624 703934 98233 78941597
Interstitial lung disease 39.55 10.07 728 703830 111872 78927958
Myocardial infarction 38.81 10.07 1285 703273 182844 78856986
Disseminated intravascular coagulation 38.49 10.07 174 704384 35668 79004162
Lethargy 38.27 10.07 497 704061 80795 78959035
Treatment noncompliance 37.84 10.07 288 704270 51980 78987850
Cerebral infarction 37.82 10.07 242 704316 45434 78994396
Neutropenic sepsis 37.79 10.07 118 704440 26946 79012884
Adverse drug reaction 37.43 10.07 390 704168 66002 78973828
Hiatus hernia 37.41 10.07 342 704216 22970 79016860
Status epilepticus 37.26 10.07 106 704452 24935 79014895
Urosepsis 37.24 10.07 378 704180 26117 79013713
Rectal haemorrhage 37.19 10.07 910 703648 75390 78964440
Withdrawal syndrome 36.85 10.07 118 704440 26736 79013094
Presyncope 36.84 10.07 538 704020 40516 78999314
Contusion 36.76 10.07 1637 702921 147139 78892691
Bursitis 36.74 10.07 481 704077 35363 79004467
Clostridium test positive 36.67 10.07 133 704425 6321 79033509
Gamma-glutamyltransferase increased 36.63 10.07 683 703875 53997 78985833
Epstein-Barr virus infection 36.61 10.07 44 704514 14372 79025458
Hepatocellular injury 36.35 10.07 607 703951 46986 78992844
Urinary hesitation 36.25 10.07 101 704457 4165 79035665
Polyneuropathy 36.10 10.07 349 704209 23802 79016028
Mucosal haemorrhage 35.82 10.07 74 704484 2512 79037318
Bronchopulmonary aspergillosis 35.71 10.07 91 704467 22203 79017627
Pyrexia 35.63 10.07 6659 697899 672050 78367780
Infective exacerbation of chronic obstructive airways disease 35.47 10.07 77 704481 2707 79037123
Sinusitis 35.38 10.07 2088 702470 193413 78846417
Alanine aminotransferase abnormal 35.37 10.07 17 704541 8850 79030980
Hyperkinesia 35.37 10.07 76 704482 2653 79037177
Paresis 35.34 10.07 100 704458 4161 79035669
Nightmare 35.23 10.07 114 704444 25747 79014083
Gastritis erosive 35.19 10.07 189 704369 10658 79029172
Haemoglobin decreased 35.18 10.07 2345 702213 219774 78820056
Blood pressure diastolic abnormal 35.14 10.07 290 704268 18912 79020918
Injection site urticaria 34.91 10.07 37 704521 12789 79027041
Oesophageal carcinoma 34.88 10.07 28 704530 11056 79028774
Tachypnoea 34.87 10.07 435 704123 31628 79008202
Gastrooesophageal reflux disease 34.20 10.07 1183 703375 103063 78936767
Visual acuity reduced 34.14 10.07 139 704419 29330 79010500
Faecaloma 33.87 10.07 196 704362 11368 79028462
Dystonia 33.77 10.07 88 704470 21311 79018519
Sickle cell anaemia with crisis 33.46 10.07 14 704544 7908 79031922
Poisoning deliberate 33.23 10.07 73 704485 18755 79021075
Injection site rash 33.03 10.07 68 704490 17886 79021944
Gastrointestinal pain 32.85 10.07 173 704385 9682 79030148
Wheezing 32.74 10.07 1301 703257 115363 78924467
Jaundice 32.55 10.07 657 703901 52692 78987138
Type I hypersensitivity 32.45 10.07 99 704459 4299 79035531
Fall 32.45 10.07 4846 699712 482783 78557047
Product use issue 32.32 10.07 1519 703039 208303 78831527
Hydrocholecystis 32.13 10.07 31 704527 502 79039328
Cardiac failure congestive 32.12 10.07 985 703573 141417 78898413
Alcohol interaction 32.07 10.07 3 704555 4871 79034959
Depressed level of consciousness 32.06 10.07 631 703927 96021 78943809
Discontinued product administered 32.00 10.07 16 704542 79 79039751
Photodermatosis 31.95 10.07 41 704517 923 79038907
Device malfunction 31.75 10.07 91 704467 21357 79018473
Pain in jaw 31.68 10.07 258 704300 45893 78993937
Osteonecrosis 31.60 10.07 154 704404 30941 79008889
Painful respiration 31.59 10.07 84 704474 3369 79036461
Tongue disorder 31.08 10.07 47 704511 13928 79025902
Cognitive disorder 30.93 10.07 433 704125 69493 78970337
Coagulation test abnormal 30.90 10.07 48 704510 1297 79038533
Hallucination 30.86 10.07 552 704006 85193 78954637
Diverticulum intestinal 30.73 10.07 154 704404 8451 79031379
Congenital hiatus hernia 30.43 10.07 37 704521 787 79039043
Tinnitus 30.36 10.07 248 704310 44085 78995745
Foetal exposure during pregnancy 30.23 10.07 7 704551 5783 79034047
Gastrointestinal angiodysplasia 30.12 10.07 42 704516 1027 79038803
Haematotoxicity 30.09 10.07 57 704501 15462 79024368
Subileus 30.02 10.07 114 704444 5540 79034290
Carotid arteriosclerosis 29.97 10.07 70 704488 2586 79037244
Mucormycosis 29.78 10.07 19 704539 8450 79031380
Exposure via ingestion 29.65 10.07 5 704553 5169 79034661
Mobility decreased 29.57 10.07 837 703721 121338 78918492
Asphyxia 29.52 10.07 36 704522 11684 79028146
Duodenitis 29.46 10.07 144 704414 7823 79032007
Hypochromic anaemia 29.42 10.07 71 704487 2680 79037150
Immune reconstitution inflammatory syndrome 29.40 10.07 48 704510 13793 79026037
Exercise tolerance decreased 29.39 10.07 158 704400 8913 79030917
Body temperature increased 29.12 10.07 553 704005 43867 78995963
Substance abuse 29.06 10.07 30 704528 10496 79029334
Appendicitis 28.79 10.07 91 704467 20703 79019127
Respiratory depression 28.57 10.07 136 704422 27494 79012336
Uterine perforation 28.52 10.07 10 704548 6293 79033537
Peripheral venous disease 28.44 10.07 239 704319 15670 79024160
Wound 28.40 10.07 1277 703281 114902 78924928
Cardiotoxicity 28.36 10.07 40 704518 12199 79027631
Anxiety 28.33 10.07 1853 702705 246659 78793171
Adenovirus infection 28.30 10.07 20 704538 8427 79031403
Trimethylaminuria 28.24 10.07 19 704539 177 79039653
Mood swings 28.24 10.07 86 704472 19794 79020036
Glomerular filtration rate decreased 28.22 10.07 316 704242 22386 79017444
Stomatitis 28.20 10.07 1576 702982 145181 78894649
Drug dose omission by device 28.13 10.07 10 704548 6240 79033590
Abnormal faeces 28.11 10.07 137 704421 7434 79032396
Sexual dysfunction 27.88 10.07 17 704541 7746 79032084
Temperature regulation disorder 27.83 10.07 114 704444 5739 79034091
Medication error 27.79 10.07 799 703759 67843 78971987
Underdose 27.78 10.07 175 704383 32976 79006854
Diarrhoea 27.20 10.07 8435 696123 872054 78167776
Drug tolerance 27.19 10.07 22 704536 8653 79031177
Nephrogenic anaemia 27.09 10.07 86 704472 3816 79036014
Chronic graft versus host disease 27.05 10.07 13 704545 6768 79033062
Eructation 26.97 10.07 177 704381 10732 79029098
Gastroenteritis clostridial 26.96 10.07 37 704521 891 79038939
Rash 26.94 10.07 4596 699962 573762 78466068
Colitis erosive 26.79 10.07 17 704541 142 79039688
Hypertensive crisis 26.69 10.07 291 704267 20479 79019351
Flatulence 26.68 10.07 528 704030 42196 78997634
Tetany 26.63 10.07 68 704490 2660 79037170
Tendonitis 26.61 10.07 114 704444 23716 79016114
Hyperreflexia 26.61 10.07 21 704537 8364 79031466
Nasal obstruction 26.60 10.07 59 704499 2105 79037725
Hyperammonaemic encephalopathy 26.58 10.07 5 704553 4777 79035053
Genital haemorrhage 26.51 10.07 11 704547 6244 79033586
Pancreatic steatosis 26.49 10.07 41 704517 1104 79038726
Right ventricular hypertrophy 26.49 10.07 50 704508 1587 79038243
Dyskinesia 26.48 10.07 260 704298 44513 78995317
Epileptic encephalopathy 26.48 10.07 27 704531 469 79039361
Breast cancer 26.45 10.07 182 704376 33599 79006231
Multiple sclerosis relapse 26.37 10.07 273 704285 46260 78993570
Alanine aminotransferase increased 26.23 10.07 1171 703387 161399 78878431
Obstruction 26.19 10.07 95 704463 4515 79035315
Vomiting 26.19 10.07 6444 698114 659384 78380446
Blood pressure systolic abnormal 26.16 10.07 250 704308 16997 79022833
C-reactive protein increased 26.05 10.07 1392 703166 127635 78912195
Vertigo 26.03 10.07 797 703761 68285 78971545
Rhinitis perennial 26.02 10.07 23 704535 331 79039499
Product quality issue 26.01 10.07 184 704374 33756 79006074
Tuberculosis 25.95 10.07 60 704498 15138 79024692
Pulmonary tuberculosis 25.85 10.07 19 704539 7846 79031984
Heavy menstrual bleeding 25.83 10.07 53 704505 13958 79025872
Abnormal dreams 25.75 10.07 38 704520 11374 79028456
Creatinine renal clearance decreased 25.72 10.07 84 704474 18918 79020912
Adrenal insufficiency 25.65 10.07 147 704411 28340 79011490
Miosis 25.64 10.07 64 704494 15725 79024105
Haematuria 25.63 10.07 793 703765 68043 78971787
Lower gastrointestinal haemorrhage 25.59 10.07 236 704322 15889 79023941
Premature rupture of membranes 25.50 10.07 3 704555 4066 79035764
Clostridium difficile infection 25.49 10.07 524 704034 42161 78997669
Red blood cell sedimentation rate increased 25.43 10.07 271 704287 45671 78994159
Gastrointestinal bacterial overgrowth 25.23 10.07 31 704527 667 79039163
Accidental overdose 25.06 10.07 226 704332 39355 79000475
Rebound acid hypersecretion 25.05 10.07 14 704544 90 79039740
Sleep disorder due to a general medical condition 24.74 10.07 213 704345 14064 79025766
Tetanus 24.70 10.07 12 704546 55 79039775
Bicytopenia 24.66 10.07 94 704464 4576 79035254
Fear of injection 24.64 10.07 18 704540 7456 79032374
Osteomyelitis 24.30 10.07 180 704378 32685 79007145
Stenosis 24.30 10.07 61 704497 2361 79037469
Degenerative mitral valve disease 24.22 10.07 21 704537 294 79039536
Paradoxical drug reaction 24.09 10.07 17 704541 7168 79032662
Sleep terror 24.07 10.07 5 704553 4453 79035377
Pulmonary function test abnormal 24.05 10.07 86 704472 4058 79035772
Ventricular enlargement 24.05 10.07 31 704527 701 79039129
Food allergy 24.01 10.07 171 704387 10653 79029177
Unevaluable event 23.94 10.07 346 704212 55239 78984591
Hepatic cyst 23.93 10.07 112 704446 5977 79033853
Respiratory tract haemorrhage 23.89 10.07 51 704507 1772 79038058
Reactive gastropathy 23.77 10.07 27 704531 533 79039297
Throat clearing 23.71 10.07 64 704494 2590 79037240
Musculoskeletal disorder 23.71 10.07 103 704455 21345 79018485
Graft versus host disease in skin 23.69 10.07 12 704546 6061 79033769
Productive cough 23.61 10.07 980 703578 87351 78952479
Blood glucose increased 23.60 10.07 805 703753 114170 78925660
Ventricular fibrillation 23.54 10.07 175 704383 31751 79008079
Bone marrow failure 23.49 10.07 314 704244 50793 78989037
Colorectal cancer 23.47 10.07 25 704533 8622 79031208
Lactic acidosis 23.46 10.07 800 703758 69559 78970271
Hepatic enzyme increased 23.32 10.07 1895 702663 180715 78859115
Acute graft versus host disease in skin 23.29 10.07 20 704538 7638 79032192
Drug effective for unapproved indication 23.19 10.07 12 704546 5989 79033841
Renal cyst 23.07 10.07 215 704343 14517 79025313
Anosognosia 23.04 10.07 3 704555 3761 79036069
Weight decreased 23.02 10.07 3525 701033 351673 78688157
Joint injury 22.99 10.07 172 704386 31163 79008667
Chronic sinusitis 22.92 10.07 195 704363 12831 79026999
Akathisia 22.92 10.07 52 704506 13207 79026623
Bronchial wall thickening 22.91 10.07 63 704495 2578 79037252
Injection site mass 22.88 10.07 96 704462 20088 79019742
Blood phosphorus increased 22.82 10.07 35 704523 10312 79029518
Osteonecrosis of jaw 22.73 10.07 258 704300 42968 78996862
Full blood count abnormal 22.59 10.07 492 704066 39982 78999848
Hypomania 22.58 10.07 20 704538 7524 79032306
Altered state of consciousness 22.48 10.07 263 704295 43559 78996271
Arrhythmia 22.32 10.07 704 703854 60568 78979262
Hyperkalaemia 22.26 10.07 1230 703328 113168 78926662
Thrombotic microangiopathy 22.21 10.07 97 704461 20072 79019758
Pregnancy with contraceptive device 22.16 10.07 3 704555 3651 79036179
Joint stiffness 22.14 10.07 242 704316 40588 78999242
Lung neoplasm malignant 22.12 10.07 149 704409 27643 79012187
Bacteriuria 22.04 10.07 40 704518 1231 79038599
Stress 22.01 10.07 535 704023 79077 78960753
Restlessness 21.91 10.07 552 704006 45940 78993890
Electrocardiogram abnormal 21.74 10.07 235 704323 16502 79023328
Vocal cord dysfunction 21.72 10.07 27 704531 588 79039242
Haematocrit decreased 21.69 10.07 702 703856 60610 78979220
Mycotic allergy 21.67 10.07 44 704514 1475 79038355
Product administered to patient of inappropriate age 21.62 10.07 11 704547 5542 79034288
Therapeutic drug monitoring analysis incorrectly performed 21.48 10.07 29 704529 687 79039143
Cardiorenal syndrome 21.46 10.07 45 704513 1544 79038286
Microcytic anaemia 21.46 10.07 98 704460 5176 79034654
Solar lentigo 21.38 10.07 37 704521 1096 79038734
Posterior reversible encephalopathy syndrome 21.37 10.07 140 704418 26141 79013689
Sopor 21.31 10.07 410 704148 32600 79007230
Granuloma skin 21.24 10.07 30 704528 9144 79030686
Alopecia 21.23 10.07 1757 702801 229598 78810232
Diplopia 21.22 10.07 191 704367 33275 79006555
Nocardiosis 21.01 10.07 12 704546 5667 79034163
Mitral valve incompetence 20.97 10.07 362 704196 28203 79011627
Gestational diabetes 20.95 10.07 15 704543 6278 79033552
Paralysis 20.94 10.07 54 704504 13123 79026707
Device leakage 20.93 10.07 40 704518 10816 79029014
Polycystic ovaries 20.90 10.07 4 704554 3775 79036055
Rib deformity 20.89 10.07 17 704541 217 79039613
Insomnia 20.86 10.07 1873 702685 243297 78796533
Dysplastic naevus 20.82 10.07 26 704532 569 79039261
Autoimmune colitis 20.80 10.07 45 704513 1578 79038252
Osteochondrosis 20.80 10.07 51 704507 1945 79037885
Serum ferritin abnormal 20.74 10.07 22 704536 401 79039429
Pericarditis 20.73 10.07 1123 703435 103113 78936717
Dissociation 20.72 10.07 5 704553 4016 79035814
Cytomegalovirus infection reactivation 20.68 10.07 28 704530 8688 79031142
Pulmonary valve disease 20.65 10.07 19 704539 289 79039541
Hepatojugular reflux 20.60 10.07 27 704531 621 79039209
Transplant rejection 20.49 10.07 95 704463 19342 79020488
Soft tissue disorder 20.45 10.07 73 704485 3442 79036388
Musculoskeletal stiffness 20.44 10.07 1302 703256 173706 78866124
Peripheral arterial occlusive disease 20.42 10.07 134 704424 8124 79031706
Palmoplantar keratoderma 20.41 10.07 4 704554 3712 79036118
Eye pruritus 20.26 10.07 103 704455 20467 79019363
Stillbirth 20.22 10.07 5 704553 3950 79035880
Skin disorder 20.12 10.07 197 704361 33746 79006084
SARS-CoV-2 antibody test positive 20.06 10.07 22 704536 417 79039413
Neurotoxicity 20.01 10.07 187 704371 32331 79007499
Glaucoma 20.00 10.07 98 704460 19663 79020167
Red blood cell count decreased 19.96 10.07 657 703901 56856 78982974
Rectal prolapse 19.94 10.07 53 704505 2125 79037705
Abortion induced 19.92 10.07 20 704538 7089 79032741
Occupational dermatitis 19.92 10.07 14 704544 141 79039689
Cytomegalovirus chorioretinitis 19.75 10.07 12 704546 5478 79034352
Generalised tonic-clonic seizure 19.74 10.07 271 704287 43639 78996191
Rhinitis allergic 19.71 10.07 50 704508 12219 79027611
Normal newborn 19.70 10.07 20 704538 7052 79032778
Injection site discolouration 19.59 10.07 23 704535 7591 79032239
Gastric ulcer 19.52 10.07 414 704144 33491 79006339
Respiratory disorder 19.52 10.07 527 704031 44329 78995501
Suspected suicide 19.51 10.07 40 704518 10536 79029294
Intraocular pressure increased 19.48 10.07 32 704526 9173 79030657
Vaginal haemorrhage 19.42 10.07 113 704445 21704 79018126
Incorrect dose administered by device 19.25 10.07 10 704548 4979 79034851
Synovial fluid analysis 19.21 10.07 55 704503 2304 79037526
BK virus infection 19.20 10.07 30 704528 8774 79031056
Lymphoproliferative disorder 19.20 10.07 13 704545 5602 79034228
Victim of child abuse 19.15 10.07 32 704526 921 79038909
Dizziness 19.14 10.07 5078 699480 521363 78518467
Accidental death 19.09 10.07 7 704551 4284 79035546
Amenorrhoea 18.98 10.07 24 704534 7668 79032162
Faecal calprotectin increased 18.97 10.07 98 704460 5443 79034387
Systolic dysfunction 18.91 10.07 75 704483 3720 79036110
Helicobacter gastritis 18.89 10.07 56 704502 2393 79037437
Pruritus 18.89 10.07 3855 700703 390793 78649037
Folate deficiency 18.88 10.07 69 704489 3291 79036539
Clostridium difficile colitis 18.85 10.07 395 704163 31888 79007942
Solar urticaria 18.84 10.07 12 704546 101 79039729
Herpes zoster 18.81 10.07 653 703905 92430 78947400
Blood pressure increased 18.77 10.07 2138 702420 209222 78830608
Panniculitis 18.67 10.07 52 704506 12319 79027511
Delusion 18.59 10.07 105 704453 20318 79019512
Dysentery 18.57 10.07 36 704522 1166 79038664
Aortic dilatation 18.56 10.07 46 704512 1766 79038064
Renal failure 18.55 10.07 2038 702520 198930 78840900
Heart rate decreased 18.54 10.07 779 703779 69537 78970293
Haematoma muscle 18.49 10.07 58 704500 2557 79037273
Anastomotic infection 18.49 10.07 13 704545 131 79039699
Blood parathyroid hormone decreased 18.47 10.07 41 704517 10495 79029335
Cystostomy 18.47 10.07 11 704547 81 79039749
Headache 18.41 10.07 5323 699235 648449 78391381
Chronic gastritis 18.38 10.07 78 704480 3990 79035840
N-terminal prohormone brain natriuretic peptide increased 18.35 10.07 87 704471 4668 79035162
Tenosynovitis 18.25 10.07 73 704485 15481 79024349
Infection 18.21 10.07 2420 702138 239292 78800538
Pancytopenia 18.20 10.07 1701 702857 164044 78875786
Electrocardiogram Q wave abnormal 18.12 10.07 25 704533 605 79039225
Hepatotoxicity 18.03 10.07 332 704226 51020 78988810
Electroencephalogram abnormal 18.03 10.07 13 704545 5421 79034409
Bronchial secretion retention 18.01 10.07 78 704480 4026 79035804
Hypochloraemia 17.98 10.07 56 704502 2459 79037371
Unresponsive to stimuli 17.96 10.07 366 704192 55422 78984408
Biliary cirrhosis 17.84 10.07 14 704544 169 79039661
Schizophrenia 17.78 10.07 73 704485 15367 79024463
Frequent bowel movements 17.76 10.07 363 704195 29176 79010654
Intracranial mass 17.75 10.07 52 704506 2207 79037623
Pneumonia cytomegaloviral 17.68 10.07 11 704547 4958 79034872
Hypovolaemic shock 17.67 10.07 176 704382 12100 79027730
Complication of device insertion 17.64 10.07 18 704540 6332 79033498
Sputum discoloured 17.60 10.07 280 704278 21463 79018367
Adjustment disorder 17.54 10.07 76 704482 3924 79035906
Liver injury 17.46 10.07 638 703920 55976 78983854
Taste disorder 17.35 10.07 215 704343 15608 79024222
Syringe issue 17.33 10.07 18 704540 6280 79033550
Graft versus host disease 17.33 10.07 71 704487 14955 79024875
Pruritus genital 17.29 10.07 9 704549 4477 79035353
Renal impairment 17.28 10.07 1619 702939 156164 78883666
Tension headache 17.28 10.07 23 704535 7188 79032642
Biliary dilatation 17.19 10.07 59 704499 2727 79037103
Chest X-ray abnormal 17.18 10.07 124 704434 7759 79032071
Inferior vena cava dilatation 17.17 10.07 29 704529 842 79038988
Metastatic malignant melanoma 17.12 10.07 60 704498 2803 79037027
Serum ferritin decreased 17.02 10.07 53 704505 2327 79037503
Pseudomembranous colitis 17.00 10.07 93 704465 5281 79034549
Hyperparathyroidism secondary 17.00 10.07 57 704501 2603 79037227
Premature labour 16.99 10.07 30 704528 8360 79031470
Retroperitoneal haematoma 16.99 10.07 92 704466 5205 79034625
Faeces pale 16.94 10.07 61 704497 2889 79036941
Procalcitonin abnormal 16.89 10.07 19 704539 371 79039459
Diffuse large B-cell lymphoma recurrent 16.88 10.07 8 704550 4199 79035631
Occult blood 16.87 10.07 43 704515 1680 79038150
Aspartate aminotransferase increased 16.78 10.07 1028 703530 137613 78902217
Troponin increased 16.75 10.07 251 704307 19004 79020826
Anal haemorrhage 16.73 10.07 78 704480 4156 79035674
Disseminated tuberculosis 16.72 10.07 8 704550 4175 79035655
Vena cava injury 16.71 10.07 18 704540 334 79039496
Inappropriate antidiuretic hormone secretion 16.70 10.07 326 704232 25987 79013843
Organic brain syndrome 16.70 10.07 21 704537 463 79039367
Device dependence 16.61 10.07 9 704549 54 79039776
Multiple organ dysfunction syndrome 16.48 10.07 881 703677 119365 78920465
Pericardial disease 16.45 10.07 23 704535 564 79039266
Spinal pain 16.38 10.07 208 704350 15184 79024646
Plasma cell myeloma 16.38 10.07 600 703958 52659 78987171
Chronic kidney disease-mineral and bone disorder 16.37 10.07 22 704536 519 79039311
Tenosynovitis stenosans 16.29 10.07 62 704496 3016 79036814
Surgery 16.29 10.07 198 704360 32568 79007262
Tardive dyskinesia 16.28 10.07 44 704514 10527 79029303
Abdominal wall haemorrhage 16.27 10.07 25 704533 669 79039161
Faeces hard 16.17 10.07 59 704499 2812 79037018
Urinary tract obstruction 16.13 10.07 84 704474 4681 79035149
Retinal haemorrhage 16.09 10.07 30 704528 8187 79031643
Gravitational oedema 16.08 10.07 44 704514 1795 79038035
Thrombosis prophylaxis 16.08 10.07 8 704550 39 79039791
Mania 16.02 10.07 95 704463 18165 79021665
Mean cell haemoglobin decreased 16.01 10.07 102 704456 6122 79033708
Viral mutation identified 16.01 10.07 7 704551 3851 79035979
Intermenstrual bleeding 15.99 10.07 17 704541 5867 79033963
Internal haemorrhage 15.95 10.07 133 704425 8700 79031130
Pneumocystis jirovecii pneumonia 15.95 10.07 197 704361 32311 79007519
Pancreatitis 15.94 10.07 750 703808 67825 78972005
Mean cell haemoglobin concentration 15.92 10.07 8 704550 40 79039790
Bradycardia 15.92 10.07 1398 703160 134159 78905671
Aortic valve incompetence 15.90 10.07 141 704417 9389 79030441
Cystitis haemorrhagic 15.83 10.07 36 704522 9136 79030694
Second primary malignancy 15.81 10.07 69 704489 14281 79025549
Intraventricular haemorrhage 15.75 10.07 85 704473 4802 79035028
Anger 15.75 10.07 88 704470 17074 79022756
Drug abuser 15.65 10.07 18 704540 5995 79033835
Immature granulocyte count increased 15.59 10.07 23 704535 593 79039237
Flank pain 15.49 10.07 254 704304 19590 79020240
Premature baby 15.46 10.07 7 704551 3773 79036057
Bone disorder 15.45 10.07 102 704456 19011 79020819
Sensitisation 15.42 10.07 5 704553 3306 79036524
Fatigue 15.38 10.07 8719 695839 921008 78118822
Meralgia paraesthetica 15.32 10.07 21 704537 505 79039325
Upper respiratory tract irritation 15.30 10.07 15 704543 248 79039582
Facet joint syndrome 15.29 10.07 160 704398 11142 79028688
Hypertransaminasaemia 15.29 10.07 167 704391 11757 79028073
Vitamin B12 deficiency 15.26 10.07 113 704445 7128 79032702
Memory impairment 15.24 10.07 819 703739 110915 78928915
Product administered at inappropriate site 15.22 10.07 8 704550 3957 79035873
Gastric cancer 15.21 10.07 43 704515 10136 79029694
Anaphylactic shock 15.18 10.07 225 704333 35771 79004059
Granulocytopenia 15.15 10.07 51 704507 11380 79028450
Discomfort 15.14 10.07 1298 703260 124319 78915511
Hepatitis B reactivation 15.13 10.07 19 704539 6089 79033741
Intestinal haemorrhage 15.13 10.07 103 704455 6323 79033507
Gastrointestinal vascular malformation haemorrhagic 15.12 10.07 26 704532 766 79039064
Blood pressure fluctuation 15.11 10.07 732 703826 66413 78973417
Crepitations 15.09 10.07 145 704413 9872 79029958
Demyelination 15.09 10.07 30 704528 7993 79031837
Cryptococcosis 15.04 10.07 6 704552 3487 79036343
Activated partial thromboplastin time prolonged 15.03 10.07 192 704366 14036 79025794
Physical examination abnormal 15.02 10.07 16 704542 293 79039537
Anaesthesia oral 14.95 10.07 4 704554 0 79039830
Application site pain 14.93 10.07 12 704546 4735 79035095
Abdominal wall wound 14.88 10.07 10 704548 93 79039737
Dysphoria 14.84 10.07 12 704546 4722 79035108
Transfusion 14.83 10.07 268 704290 21062 79018768
Dental caries 14.82 10.07 54 704504 11766 79028064
Hepatocellular carcinoma 14.81 10.07 133 704425 8888 79030942
Gastroenteritis viral 14.76 10.07 144 704414 24687 79015143
Strongyloidiasis 14.76 10.07 8 704550 3890 79035940
Urinary tract infection enterococcal 14.75 10.07 63 704495 3232 79036598
Complication of device removal 14.70 10.07 8 704550 3881 79035949
Confabulation 14.68 10.07 20 704538 478 79039352
Acute generalised exanthematous pustulosis 14.65 10.07 224 704334 17030 79022800
Procalcitonin increased 14.65 10.07 59 704499 2947 79036883
Disability assessment scale score increased 14.63 10.07 65 704493 3393 79036437
Thrombophlebitis 14.59 10.07 101 704457 6234 79033596
Migraine 14.56 10.07 628 703930 86865 78952965
Spontaneous haemorrhage 14.54 10.07 26 704532 791 79039039
Acute respiratory distress syndrome 14.52 10.07 288 704270 43779 78996051
Arteriosclerotic gangrene 14.50 10.07 9 704549 72 79039758
Hyperprolactinaemia 14.48 10.07 12 704546 4664 79035166
Disorientation 14.47 10.07 686 703872 62090 78977740
Vascular purpura 14.46 10.07 60 704498 3038 79036792
Cerebral ischaemia 14.45 10.07 157 704401 11038 79028792
Stupor 14.44 10.07 24 704534 6848 79032982
Foetal death 14.35 10.07 31 704527 8013 79031817
Alcohol use 14.23 10.07 13 704545 4818 79035012
Coma scale abnormal 14.23 10.07 35 704523 8643 79031187
Scleritis 14.20 10.07 76 704482 4280 79035550
Gingival hypertrophy 14.19 10.07 5 704553 3137 79036693
Incorrect route of product administration 14.16 10.07 220 704338 34709 79005121
Salpingo-oophorectomy unilateral 14.15 10.07 26 704532 808 79039022
Dermatitis exfoliative generalised 14.14 10.07 111 704447 7130 79032700
Coronavirus test positive 14.13 10.07 31 704527 1098 79038732
Steroid dependence 14.10 10.07 3 704555 2627 79037203
Poor venous access 14.05 10.07 232 704326 17917 79021913
Cholecystitis 14.04 10.07 275 704283 21937 79017893
Monocyte count increased 13.99 10.07 150 704408 10511 79029319
Mitochondrial toxicity 13.99 10.07 5 704553 3109 79036721
Pneumonitis chemical 13.98 10.07 19 704539 453 79039377
Activated partial thromboplastin time shortened 13.98 10.07 27 704531 872 79038958
Femoral hernia incarcerated 13.97 10.07 26 704532 816 79039014
Pancreatic duct stenosis 13.97 10.07 14 704544 238 79039592
Cardiac aneurysm 13.96 10.07 37 704521 1481 79038349
Apparent death 13.93 10.07 4 704554 2861 79036969
Hepatitis 13.93 10.07 614 703944 55113 78984717
Disturbance in social behaviour 13.91 10.07 14 704544 4956 79034874
Lip swelling 13.90 10.07 266 704292 40645 78999185
Stasis dermatitis 13.89 10.07 35 704523 1358 79038472
Congenital coronary artery malformation 13.81 10.07 10 704548 106 79039724
Haemorrhagic erosive gastritis 13.77 10.07 24 704534 715 79039115
Toxic skin eruption 13.75 10.07 275 704283 22018 79017812
Lung disorder 13.74 10.07 856 703702 79701 78960129
Transient aphasia 13.74 10.07 19 704539 461 79039369
Cryptitis 13.73 10.07 15 704543 283 79039547
Intraductal papillary mucinous neoplasm 13.70 10.07 25 704533 773 79039057
Hepatitis acute 13.68 10.07 203 704355 15339 79024491
Benign gastrointestinal neoplasm 13.67 10.07 11 704547 138 79039692
Troponin abnormal 13.62 10.07 7 704551 37 79039793
Impaired quality of life 13.62 10.07 73 704485 14313 79025517
Atheroembolism 13.62 10.07 16 704542 328 79039502
Renal cyst haemorrhage 13.59 10.07 23 704535 669 79039161
Injury associated with device 13.57 10.07 7 704551 3499 79036331
Pulmonary embolism 13.48 10.07 1723 702835 169931 78869899
Thinking abnormal 13.48 10.07 65 704493 13096 79026734
Epidural lipomatosis 13.46 10.07 32 704526 1196 79038634
Bile duct stone 13.41 10.07 90 704468 5499 79034331
Microvillous inclusion disease 13.40 10.07 13 704545 212 79039618
Smear cervix abnormal 13.37 10.07 3 704555 2533 79037297
Lumbar vertebral fracture 13.36 10.07 107 704451 6915 79032915
Umbilical hernia 13.35 10.07 93 704465 5752 79034078
Cryopyrin associated periodic syndrome 13.27 10.07 17 704541 382 79039448
Epigastric discomfort 13.26 10.07 117 704441 7779 79032051
Haemophagocytic lymphohistiocytosis 13.25 10.07 126 704432 21711 79018119
Neck pain 13.25 10.07 538 704020 74879 78964951
Hypoxic-ischaemic encephalopathy 13.25 10.07 31 704527 7789 79032041
Epilepsy 13.22 10.07 463 704095 40397 78999433
Antineutrophil cytoplasmic antibody positive 13.22 10.07 33 704525 1273 79038557
Coeliac disease 13.21 10.07 156 704402 11195 79028635
Periarthritis calcarea 13.19 10.07 9 704549 86 79039744
Urine alcohol test positive 13.18 10.07 6 704552 23 79039807
Diabetic ketoacidosis 13.13 10.07 217 704341 33905 79005925
Obsessive-compulsive disorder 13.12 10.07 20 704538 5907 79033923
Anaemia of malignant disease 13.10 10.07 25 704533 800 79039030
Mixed liver injury 13.10 10.07 113 704445 7465 79032365
Toothache 13.09 10.07 113 704445 19857 79019973
Intestinal obstruction 13.07 10.07 484 704074 42536 78997294
Device deployment issue 13.06 10.07 6 704552 3206 79036624
Product complaint 13.06 10.07 67 704491 13282 79026548
TP53 gene mutation 13.05 10.07 7 704551 41 79039789
Hyperlipasaemia 13.02 10.07 32 704526 1222 79038608
Endophthalmitis 13.00 10.07 23 704535 6405 79033425
Electrocardiogram T wave alternans 12.99 10.07 8 704550 63 79039767
Circulatory collapse 12.99 10.07 430 704128 37238 79002592
Miller Fisher syndrome 12.99 10.07 14 704544 260 79039570
Petit mal epilepsy 12.99 10.07 19 704539 5708 79034122
Glomerulonephropathy 12.90 10.07 15 704543 304 79039526
Erythema multiforme 12.90 10.07 97 704461 17554 79022276
Total lung capacity abnormal 12.88 10.07 13 704545 223 79039607
Ventricular arrhythmia 12.85 10.07 127 704431 8713 79031117
Vascular stent stenosis 12.83 10.07 36 704522 1491 79038339
Tearfulness 12.81 10.07 21 704537 6024 79033806
Carcinoid tumour of the stomach 12.81 10.07 12 704546 187 79039643
Metabolic disorder 12.79 10.07 40 704518 9130 79030700
Mental status changes 12.78 10.07 473 704085 66486 78973344
Therapeutic reaction time decreased 12.75 10.07 63 704495 3438 79036392
Occupational exposure to air contaminants 12.75 10.07 11 704547 153 79039677
Renal cancer 12.74 10.07 60 704498 12166 79027664
Oesophageal candidiasis 12.71 10.07 131 704427 9087 79030743
Bacterial infection 12.68 10.07 197 704361 31083 79008747
Virologic failure 12.68 10.07 11 704547 4180 79035650
Enteritis 12.65 10.07 190 704368 14393 79025437
Accidental exposure to product by child 12.64 10.07 5 704553 2921 79036909
Laryngeal stenosis 12.64 10.07 29 704529 1059 79038771
Alkalosis 12.51 10.07 20 704538 554 79039276
Swelling face 12.51 10.07 508 704050 70704 78969126
Deafness 12.51 10.07 122 704436 20915 79018915
Vascular anastomotic haemorrhage 12.46 10.07 14 704544 273 79039557
Waist circumference increased 12.44 10.07 38 704520 1651 79038179
Leptospirosis 12.44 10.07 6 704552 27 79039803
Alveolar lung disease 12.44 10.07 20 704538 557 79039273
Retinal detachment 12.43 10.07 41 704517 9206 79030624
Eosinophils urine present 12.40 10.07 8 704550 69 79039761
Pancreatic enzyme abnormality 12.39 10.07 10 704548 126 79039704
Prerenal failure 12.38 10.07 65 704493 3633 79036197
Cholecystitis chronic 12.36 10.07 138 704420 9768 79030062
Left ventricular enlargement 12.34 10.07 23 704535 723 79039107
Orthostatic hypotension 12.29 10.07 390 704168 55774 78984056
Paranoia 12.28 10.07 111 704447 19321 79020509
Left ventricular hypertrophy 12.24 10.07 152 704406 11039 79028791
Xyphoid retraction 12.24 10.07 11 704547 162 79039668
Sensory level abnormal 12.24 10.07 11 704547 162 79039668
Injection site induration 12.22 10.07 45 704513 9774 79030056
Feeling jittery 12.21 10.07 170 704388 12671 79027159
Periodontitis 12.20 10.07 13 704545 4483 79035347
Arterial stenosis 12.20 10.07 34 704524 1402 79038428
Cough 12.18 10.07 3525 701033 363264 78676566
Meningitis cryptococcal 12.15 10.07 8 704550 3498 79036332
Myalgia 12.13 10.07 1445 703113 184196 78855634
Hemiparesis 12.13 10.07 387 704171 33346 79006484
Stress cardiomyopathy 12.11 10.07 54 704504 11112 79028718
Blindness 12.11 10.07 177 704381 28206 79011624
Pneumonia viral 12.09 10.07 129 704429 9029 79030801
Influenza like illness 12.07 10.07 514 704044 71193 78968637
Histoplasmosis 12.07 10.07 3 704555 2362 79037468
Retro-orbital neoplasm 12.04 10.07 7 704551 49 79039781
Pseudarthrosis 12.03 10.07 14 704544 284 79039546
Food aversion 11.98 10.07 28 704530 1035 79038795
Perihepatic abscess 11.97 10.07 11 704547 167 79039663
Bradyarrhythmia 11.96 10.07 70 704488 4076 79035754
Eyelid haematoma 11.93 10.07 7 704551 50 79039780
Tumour pain 11.91 10.07 46 704512 2253 79037577
Lip oedema 11.89 10.07 96 704462 6220 79033610
Neutropenia 11.84 10.07 2301 702257 285409 78754421
Lipase increased 11.84 10.07 208 704350 16258 79023572
Acute megakaryocytic leukaemia 11.81 10.07 7 704551 51 79039779
Ankylosing spondylitis 11.77 10.07 162 704396 12043 79027787
Nocturia 11.77 10.07 178 704380 13503 79026327
Disease recurrence 11.76 10.07 298 704260 43811 78996019
Dermatosis 11.76 10.07 20 704538 584 79039246
Sebaceous gland infection 11.76 10.07 11 704547 171 79039659
Duodenogastric reflux 11.72 10.07 9 704549 105 79039725
Parkinsonism 11.71 10.07 92 704466 16492 79023338
Lipoedema 11.70 10.07 12 704546 210 79039620
Brain oedema 11.69 10.07 155 704403 25108 79014722
Wrong technique in device usage process 11.67 10.07 11 704547 4017 79035813
Bruxism 11.66 10.07 11 704547 4015 79035815
Hostility 11.66 10.07 3 704555 2307 79037523
Paronychia 11.65 10.07 33 704525 7775 79032055
Cold sweat 11.65 10.07 231 704327 18468 79021362
Viral infection 11.64 10.07 290 704268 42726 78997104
Inability to afford medication 11.63 10.07 52 704506 2721 79037109
Puncture site haematoma 11.61 10.07 11 704547 174 79039656
Fibromyalgia 11.59 10.07 687 703871 63653 78976177
Incision site haemorrhage 11.58 10.07 28 704530 1058 79038772
Gastrointestinal toxicity 11.57 10.07 35 704523 8074 79031756
Application site erythema 11.54 10.07 17 704541 5093 79034737
COVID-19 11.52 10.07 1218 703340 156456 78883374
Bladder diverticulum 11.51 10.07 9 704549 108 79039722
Tic 11.50 10.07 6 704552 2980 79036850
Emotional distress 11.49 10.07 267 704291 39702 79000128
Erectile dysfunction 11.48 10.07 79 704479 14585 79025245
Maternal exposure before pregnancy 11.48 10.07 13 704545 4360 79035470
Perineal cyst 11.47 10.07 13 704545 256 79039574
Injection site irritation 11.40 10.07 10 704548 3780 79036050
Metastases to lung 11.37 10.07 104 704454 18059 79021771
Neurosensory hypoacusis 11.34 10.07 12 704546 218 79039612
Vascular dissection 11.21 10.07 3 704555 0 79039830
Bladder diverticulitis 11.21 10.07 3 704555 0 79039830
Scrotal inflammation 11.21 10.07 3 704555 0 79039830
Metabolic surgery 11.19 10.07 29 704529 1145 79038685
Natural killer cell count decreased 11.18 10.07 7 704551 57 79039773
Feeling hot 11.17 10.07 423 704135 59311 78980519
Lymphatic fistula 11.15 10.07 23 704535 780 79039050
Total lung capacity decreased 11.10 10.07 53 704505 2852 79036978
Contraindicated product administered 11.08 10.07 1571 702987 155967 78883863
Palmar-plantar erythrodysaesthesia syndrome 11.08 10.07 216 704342 32918 79006912
Cardiovascular somatic symptom disorder 11.07 10.07 6 704552 36 79039794
Human herpesvirus 6 infection 11.06 10.07 19 704539 5351 79034479
Aspergillus infection 11.02 10.07 112 704446 19049 79020781
Areflexia 11.02 10.07 20 704538 5514 79034316
Cerebellar ischaemia 11.00 10.07 12 704546 226 79039604
Probiotic therapy 10.98 10.07 10 704548 150 79039680
Bacteraemia 10.97 10.07 214 704344 32610 79007220
Internal fixation of fracture 10.97 10.07 15 704543 360 79039470
Gene mutation 10.95 10.07 5 704553 2681 79037149
Impaired work ability 10.93 10.07 116 704442 19565 79020265
Polyuria 10.92 10.07 190 704368 14824 79025006
Focal dyscognitive seizures 10.89 10.07 9 704549 3503 79036327
Metastases to bone 10.89 10.07 151 704407 24276 79015554
Acute coronary syndrome 10.89 10.07 254 704304 20879 79018951
Iridocyclitis 10.87 10.07 10 704548 3694 79036136
Nausea 10.83 10.07 8886 695672 948310 78091520
Mood altered 10.82 10.07 103 704455 17744 79022086
Pancreatic carcinoma stage IV 10.82 10.07 3 704555 2195 79037635
Uterine cancer 10.79 10.07 10 704548 3681 79036149
Gait deviation 10.79 10.07 7 704551 61 79039769
Blood calcium decreased 10.77 10.07 207 704351 31612 79008218
Vaccination site reaction 10.74 10.07 9 704549 120 79039710
Gastroenteritis salmonella 10.72 10.07 27 704531 1047 79038783
Tongue oedema 10.71 10.07 103 704455 7014 79032816
Anosmia 10.70 10.07 41 704517 8803 79031027
Peripheral nerve paresis 10.68 10.07 6 704552 39 79039791
Chronic actinic dermatitis 10.63 10.07 5 704553 21 79039809
Base excess decreased 10.63 10.07 15 704543 371 79039459
Helicobacter test false negative 10.60 10.07 7 704551 63 79039767
Aortic arteriosclerosis 10.57 10.07 123 704435 8795 79031035
Cytomegalovirus test positive 10.54 10.07 23 704535 5924 79033906
Thoracic vertebral fracture 10.52 10.07 81 704477 5172 79034658
Urine output decreased 10.51 10.07 105 704453 17917 79021913
Rapid correction of hyponatraemia 10.51 10.07 10 704548 159 79039671
Chronic obstructive pulmonary disease 10.51 10.07 884 703674 84535 78955295
Bladder hypertrophy 10.50 10.07 20 704538 639 79039191
Hepatitis B 10.49 10.07 38 704520 8294 79031536
Stoma site discharge 10.48 10.07 43 704515 2166 79037664
Pain in extremity 10.48 10.07 2965 701593 361573 78678257
Alveolitis 10.44 10.07 68 704490 4112 79035718
Chest injury 10.44 10.07 51 704507 2770 79037060
Myeloblast percentage decreased 10.44 10.07 6 704552 41 79039789
Staphylococcal infection 10.42 10.07 415 704143 57880 78981950
Adrenal cyst 10.41 10.07 10 704548 161 79039669
Device dislocation 10.38 10.07 164 704394 25806 79014024
Dysphagia 10.37 10.07 1232 703326 120904 78918926
Muscle twitching 10.37 10.07 155 704403 24609 79015221
Labelled drug-food interaction medication error 10.36 10.07 10 704548 162 79039668
Bone marrow oedema 10.35 10.07 36 704522 1675 79038155
Optic neuritis 10.35 10.07 46 704512 9474 79030356
Soft tissue swelling 10.35 10.07 33 704525 1468 79038362
Vascular access site complication 10.32 10.07 4 704554 9 79039821
Foot operation 10.31 10.07 22 704536 5711 79034119
Gastrointestinal inflammation 10.30 10.07 107 704451 7437 79032393
Pneumothorax 10.29 10.07 182 704376 28141 79011689
Cross sensitivity reaction 10.28 10.07 62 704496 3650 79036180
Pulmonary sepsis 10.28 10.07 62 704496 3650 79036180
Neutrophil function disorder 10.28 10.07 5 704553 23 79039807
Lupus nephritis 10.24 10.07 7 704551 3001 79036829
Foetal growth restriction 10.23 10.07 3 704555 2116 79037714
X-ray abnormal 10.22 10.07 87 704471 5726 79034104
Wrist deformity 10.21 10.07 3 704555 2114 79037716
Abdominal wall cyst 10.21 10.07 6 704552 43 79039787
Device breakage 10.20 10.07 54 704504 10621 79029209
Chondrocalcinosis pyrophosphate 10.19 10.07 37 704521 1759 79038071
Arterial occlusive disease 10.19 10.07 117 704441 8339 79031491
Atrial enlargement 10.18 10.07 26 704532 1017 79038813
Limb deformity 10.18 10.07 10 704548 3580 79036250
Blood pressure measurement 10.17 10.07 16 704542 437 79039393
Toxic neuropathy 10.17 10.07 25 704533 955 79038875
Mean cell volume increased 10.17 10.07 92 704466 6161 79033669
Hepatic steatosis 10.15 10.07 419 704139 37319 79002511
Cardiomyopathy 10.11 10.07 186 704372 28588 79011242
Blood pressure decreased 10.11 10.07 749 703809 98717 78941113
Oesophageal variceal ligation 10.10 10.07 9 704549 131 79039699
Deep vein thrombosis postoperative 10.08 10.07 142 704416 10610 79029220

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A02BC02 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Proton pump inhibitors
ATC A02BD04 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Combinations for eradication of Helicobacter pylori
ATC A02BD11 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Combinations for eradication of Helicobacter pylori
FDA MoA N0000000147 Proton Pump Inhibitors
FDA EPC N0000175525 Proton Pump Inhibitor
MeSH PA D000897 Anti-Ulcer Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D054328 Proton Pump Inhibitors
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:49200 proton pump inhibitors
CHEBI has role CHEBI:49201 anti-ulcer drugs
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Erosive esophagitis indication 40719004
Zollinger-Ellison syndrome indication 53132006 DOID:0050782
Multiple endocrine adenomas indication 60549007
Gastroesophageal reflux disease indication 235595009 DOID:8534
Maintenance of Healing Erosive Esophagitis indication
Gastric Hypersecretory Conditions indication
Upper gastrointestinal hemorrhage off-label use 37372002
Duodenal ulcer disease off-label use 51868009 DOID:1724
Gastric ulcer off-label use 397825006 DOID:10808
Pathological Gastric Hypersecretory Condition off-label use
Duodenal Ulcer due to H. Pylori off-label use
Prevention of NSAID-Induced Gastric Ulcer off-label use
Osteoporosis contraindication 64859006 DOID:11476
Pernicious anemia contraindication 84027009 DOID:13381
Fracture of bone contraindication 125605004
Hypomagnesemia contraindication 190855004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.42 acidic
pKa2 3.58 Basic
pKa3 2.32 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 40MG BASE PROTONIX WYETH PHARMS N022020 Nov. 14, 2007 RX FOR SUSPENSION, DELAYED RELEASE ORAL 7550153 Sept. 30, 2024 EROSIVE ESOPHAGITIS, HYPERSECRETORY CONDITIONS INCLUDING ZOLLINGER-ELLISON SYNDROME, MAINTENANCE OF HEALING OF EROSIVE ESOPHAGITIS AND REDUCTION OF SYMPTOMS IN PATIENTS WITH GERD
EQ 40MG BASE PROTONIX WYETH PHARMS N022020 Nov. 14, 2007 RX FOR SUSPENSION, DELAYED RELEASE ORAL 7553498 Sept. 30, 2024 EROSIVE ESOPHAGITIS, HYPERSECRETORY CONDITIONS INCLUDING ZOLLINGER-ELLISON SYNDROME, MAINTENANCE OF HEALING OF EROSIVE ESOPHAGITIS AND REDUCTION OF SYMPTOMS IN PATIENTS WITH GERD
EQ 40MG BASE PROTONIX WYETH PHARMS N022020 Nov. 14, 2007 RX FOR SUSPENSION, DELAYED RELEASE ORAL 7838027 Sept. 30, 2024 EROSIVE ESOPHAGITIS, HYPERSECRETORY CONDITIONS INCLUDING ZOLLINGER-ELLISON SYNDROME, MAINTENANCE OF HEALING OF EROSIVE ESOPHAGITIS AND REDUCTION OF SYMPTOMS IN PATIENTS WITH GERD

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Potassium-transporting ATPase Transporter INHIBITOR CHEMBL CHEMBL
ATP-binding cassette sub-family G member 2 Transporter IC50 5.26 CHEMBL
Fatty acid synthase Enzyme Ki 5.39 CHEMBL
Solute carrier family 22 member 2 Transporter IC50 5.82 CHEMBL
Multidrug and toxin extrusion protein 1 Transporter IC50 5.55 CHEMBL
Multidrug and toxin extrusion protein 2 Transporter IC50 4.36 CHEMBL
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 Enzyme IC50 4.20 CHEMBL
Sodium/potassium-transporting ATPase subunit alpha-1 Transporter WOMBAT-PK
Indoleamine 2,3-dioxygenase 2 Enzyme IC50 4.90 CHEMBL
Potassium-transporting ATPase Enzyme IC50 6 SCIENTIFIC LITERATURE

External reference:

IDSource
4021208 VUID
N0000148654 NUI
D02593 KEGG_DRUG
164579-32-2 SECONDARY_CAS_RN
4021208 VANDF
4021209 VANDF
C0081876 UMLSCUI
CHEBI:7915 CHEBI
CHEMBL1502 ChEMBL_ID
DB00213 DRUGBANK_ID
CHEMBL3989559 ChEMBL_ID
CHEMBL1200408 ChEMBL_ID
D000077402 MESH_DESCRIPTOR_UI
4679 PUBCHEM_CID
7260 IUPHAR_LIGAND_ID
6548 INN_ID
D8TST4O562 UNII
236632 RXNORM
130104 MMSL
8654 MMSL
d04514 MMSL
006006 NDDF
006493 NDDF
009120 NDDF
116510001 SNOMEDCT_US
317317009 SNOMEDCT_US
395821003 SNOMEDCT_US
432408008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Protonix Delayed-Release HUMAN PRESCRIPTION DRUG LABEL 1 0008-0841 TABLET, DELAYED RELEASE 40 mg ORAL NDA 30 sections
Protonix Delayed-Release HUMAN PRESCRIPTION DRUG LABEL 1 0008-0841 TABLET, DELAYED RELEASE 40 mg ORAL NDA 30 sections
Protonix Delayed-Release HUMAN PRESCRIPTION DRUG LABEL 1 0008-0841 TABLET, DELAYED RELEASE 40 mg ORAL NDA 30 sections
Protonix Delayed-Release HUMAN PRESCRIPTION DRUG LABEL 1 0008-0843 TABLET, DELAYED RELEASE 20 mg ORAL NDA 30 sections
Protonix Delayed-Release HUMAN PRESCRIPTION DRUG LABEL 1 0008-0843 TABLET, DELAYED RELEASE 20 mg ORAL NDA 30 sections
Protonix Delayed-Release HUMAN PRESCRIPTION DRUG LABEL 1 0008-0843 TABLET, DELAYED RELEASE 20 mg ORAL NDA 30 sections
Protonix Delayed-Release HUMAN PRESCRIPTION DRUG LABEL 1 0008-0844 GRANULE, DELAYED RELEASE 40 mg ORAL NDA 30 sections
Protonix Delayed-Release HUMAN PRESCRIPTION DRUG LABEL 1 0008-0844 GRANULE, DELAYED RELEASE 40 mg ORAL NDA 30 sections
Protonix Delayed-Release HUMAN PRESCRIPTION DRUG LABEL 1 0008-0844 GRANULE, DELAYED RELEASE 40 mg ORAL NDA 30 sections
Protonix I.V. HUMAN PRESCRIPTION DRUG LABEL 1 0008-0923 INJECTION, POWDER, FOR SOLUTION 40 mg INTRAVENOUS NDA 28 sections
Protonix I.V. HUMAN PRESCRIPTION DRUG LABEL 1 0008-0923 INJECTION, POWDER, FOR SOLUTION 40 mg INTRAVENOUS NDA 28 sections
Protonix I.V. HUMAN PRESCRIPTION DRUG LABEL 1 0008-0923 INJECTION, POWDER, FOR SOLUTION 40 mg INTRAVENOUS NDA 28 sections
Protonix I.V. HUMAN PRESCRIPTION DRUG LABEL 1 0008-2001 INJECTION, POWDER, FOR SOLUTION 40 mg INTRAVENOUS NDA 27 sections
Protonix I.V. HUMAN PRESCRIPTION DRUG LABEL 1 0008-2001 INJECTION, POWDER, FOR SOLUTION 40 mg INTRAVENOUS NDA 27 sections
Protonix I.V. HUMAN PRESCRIPTION DRUG LABEL 1 0008-4001 INJECTION, POWDER, FOR SOLUTION 40 mg INTRAVENOUS NDA 28 sections
Protonix I.V. HUMAN PRESCRIPTION DRUG LABEL 1 0008-4001 INJECTION, POWDER, FOR SOLUTION 40 mg INTRAVENOUS NDA 28 sections
Protonix I.V. HUMAN PRESCRIPTION DRUG LABEL 1 0008-4001 INJECTION, POWDER, FOR SOLUTION 40 mg INTRAVENOUS NDA 28 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9284 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 40 mg INTRAVENOUS NDA 26 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9284 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 40 mg INTRAVENOUS NDA 26 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9300 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 40 mg INTRAVENOUS NDA 26 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9300 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 40 mg INTRAVENOUS NDA 26 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-6688 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 28 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-6688 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 28 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-6688 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 28 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-6689 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 28 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-6689 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 28 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-6689 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 28 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0480-4111 INJECTION, POWDER, FOR SOLUTION 40 mg INTRAVENOUS ANDA 28 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-7629 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 28 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-8113 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 27 sections