aminosalicylic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
2050 65-49-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • aminosalicylic acid resin complex
  • potassium aminosalicylate
  • p-aminosalicylic acid
  • aminosalicylic acid
  • 4-Aminosalicylic acid
  • 4-Carboxy-3-hydroxyaniline
  • apacil
  • calcium aminosalicylate
  • sodium aminosalicylate
  • para-aminosalicylic acid
  • aminosalicylate potassium
  • aminosalicylate sodium
  • teebacin
An antitubercular agent often administered in association with ISONIAZID. The sodium salt of the drug is better tolerated than the free acid.
  • Molecular weight: 153.14
  • Formula: C7H7NO3
  • CLOGP: 1.06
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 3
  • TPSA: 83.55
  • ALOGS: -1.11
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
12 g O
14 g O
14 g P
15 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Bocci G, Oprea TI, Benet LZ
S (Water solubility) 1.69 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 2 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1306.01 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -1.241 Moderate 0.69
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.738 Moderate 0.69
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 2.512 10^-6 cm/s Moderate 0.69
dh-clint Dog hepatocyte intrinsic clearance 1.746 uL/min/10^6 cells Moderate 0.69
dppb Dog plasma protein binding (% unbound) 15.520 % Moderate 0.69
fcs-ppb Fetal calf serum protein binding (% unbound) 38.360 % Moderate 0.69
herg hERG pIC50 4.557 pIC50 Moderate 0.69
hh-clint Human hepatocyte intrinsic clearance 1.384 uL/min/10^6 cells Moderate 0.69
hlm-clint Human liver microsomal intrinsic clearance 3.548 uL/min/mg protein Moderate 0.69
hppb Human plasma protein binding (% unbound) 15.250 % Moderate 0.69
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AURKC,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,KDR,KIT,MAP2K6,MAP3K1,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK1,MAPK10,MAPK12,MAPK14,MAPK7,MAPK8,MAPK9,MAPKAPK2,MAPKAPK5,MARK4,MTOR,NTRK1,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM1,PIM2,PLK1,PRKCD,PRKDC,SGK1,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70 77
kinase-selectivity-class ACVR2A,ACVR2B,AURKB,AXL,BRAF,CAMK2B,CAMK2D,CDK4,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,IKBKB,JAK2,MAP2K3,MAP2K6,MAP3K14,MAPK12,MAPK7,MAPK8,MARK4,PIK3CB,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,TTK,UHMK1,ULK1,ULK2 35
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.673 Moderate 0.69
mh-clint Mouse hepatocyte intrinsic clearance 4.159 Moderate 0.69
mppb Mouse plasma protein binding (% unbound) 37.920 Moderate 0.69
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.284 Moderate 0.69
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 Moderate 0.69
pppb Pig plasma protein binding (% unbound) 27.270 % Moderate 0.69
rh-clint Rat hepatocyte intrinsic clearance 6.855 uL/min/10^6 cells Moderate 0.69
rh-fuinc Rat hepatocyte fraction unbound in incubation 79.510 % Moderate 0.69
rppb Rat plasma protein binding (% unbound) 18.150 % Moderate 0.69
solubility-dd Solubility at pH 7.4 in DMSO 866.962 uM Moderate 0.69

Approvals:

DateAgencyCompanyOrphan
March 8, 1950 FDA CONSOLIDATED MIDLAND

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Colitis ulcerative 395.21 39.55 272 38534 59994 90529647
Retinitis 326.34 39.55 204 38602 38254 90551387
Frequent bowel movements 306.64 39.55 228 38578 56707 90532934
Porphyria acute 300.47 39.55 149 38657 17826 90571815
Dislocation of vertebra 287.78 39.55 218 38588 55750 90533891
Lupus-like syndrome 281.99 39.55 204 38602 48642 90540999
Wound infection 271.05 39.55 278 38528 106124 90483517
Adjustment disorder with depressed mood 261.17 39.55 207 38599 56546 90533095
Lupus vulgaris 250.59 39.55 184 38622 44875 90544766
Joint dislocation 229.93 39.55 174 38632 44408 90545233
Laryngitis 222.61 39.55 180 38626 50573 90539068
Rectal haemorrhage 210.32 39.55 216 38590 82528 90507113
Bone erosion 201.32 39.55 173 38633 52848 90536793
Walking aid user 199.69 39.55 146 38660 35360 90554281
Exostosis 192.92 39.55 169 38637 52965 90536676
Hepatic cirrhosis 190.21 39.55 181 38625 63072 90526569
Foot deformity 183.77 39.55 173 38633 59478 90530163
Grip strength 179.12 39.55 84 38722 8881 90580760
Delirium 178.97 39.55 222 38584 104137 90485504
Autoimmune disorder 176.58 39.55 190 38616 76554 90513087
Osteoporosis 176.31 39.55 212 38594 96319 90493322
Breast cancer stage III 173.46 39.55 197 38609 84250 90505391
Joint range of motion decreased 172.00 39.55 249 38557 135394 90454247
Road traffic accident 167.24 39.55 218 38588 107408 90482233
Fall 160.66 39.55 12 38794 481798 90107843
Type 2 diabetes mellitus 158.88 39.55 300 38506 202944 90386697
Visual impairment 157.74 39.55 236 38570 132129 90457512
Sciatica 156.97 39.55 205 38601 101177 90488464
X-ray abnormal 154.00 39.55 139 38667 45285 90544356
Lower limb fracture 152.45 39.55 185 38621 84828 90504813
Ear infection 152.24 39.55 168 38638 69607 90520034
Pancreatitis 152.14 39.55 168 38638 69658 90519983
Pulmonary fibrosis 150.57 39.55 207 38599 107296 90482345
Joint stiffness 150.09 39.55 176 38630 77866 90511775
Hypercholesterolaemia 150.01 39.55 200 38606 100692 90488949
Prescribed underdose 148.98 39.55 172 38634 74847 90514794
Deep vein thrombosis postoperative 148.50 39.55 167 38639 70642 90518999
Seronegative arthritis 145.31 39.55 93 38713 18141 90571500
Amnesia 144.60 39.55 204 38602 108301 90481340
Sleep disorder due to a general medical condition 134.43 39.55 128 38678 44610 90545031
Drug ineffective 133.76 39.55 244 38562 1384054 89205587
Rheumatic fever 128.37 39.55 233 38573 152888 90436753
Grip strength decreased 124.74 39.55 175 38631 92401 90497240
Swollen joint count increased 118.04 39.55 188 38618 111018 90478623
Osteoarthritis 116.30 39.55 258 38548 195472 90394169
Muscle injury 115.43 39.55 242 38564 176412 90413229
Cough 115.33 39.55 12 38794 368950 90220691
Prescribed overdose 109.10 39.55 169 38637 97456 90492185
Sleep disorder due to general medical condition, insomnia type 106.79 39.55 195 38611 128499 90461142
Red blood cell sedimentation rate increased 106.64 39.55 153 38653 82442 90507199
Irritable bowel syndrome 105.23 39.55 257 38549 207191 90382450
Product dose omission issue 103.99 39.55 5 38801 291682 90297959
Urinary tract infection 100.71 39.55 8 38798 305624 90284017
Hypotension 100.62 39.55 11 38795 325386 90264255
Lip dry 99.43 39.55 165 38641 100790 90488851
Rheumatoid factor positive 98.30 39.55 223 38583 171427 90418214
Acute kidney injury 91.43 39.55 14 38792 320373 90269268
Feeling hot 91.32 39.55 138 38668 77870 90511771
Toxicity to various agents 90.87 39.55 9 38797 287837 90301804
Wheezing 89.49 39.55 264 38542 237816 90351825
Drug interaction 88.98 39.55 8 38798 276445 90313196
Impaired healing 86.41 39.55 258 38548 233941 90355700
White blood cell count increased 85.97 39.55 124 38682 67117 90522524
Oedema 85.91 39.55 233 38573 200062 90389579
Back pain 85.78 39.55 16 38790 317159 90272482
Fibromyalgia 85.54 39.55 237 38569 206032 90383609
Anti-cyclic citrullinated peptide antibody 83.89 39.55 79 38727 27142 90562499
Swollen joint count 83.85 39.55 50 38756 8603 90581038
Hip arthroplasty 83.84 39.55 131 38675 76077 90513564
Blood cholesterol increased 83.31 39.55 236 38570 207776 90381865
Peripheral venous disease 81.08 39.55 136 38670 83785 90505856
Neutropenia 79.69 39.55 4 38802 224900 90364741
Liver disorder 79.01 39.55 166 38640 121103 90468538
Laboratory test abnormal 78.13 39.55 93 38713 41761 90547880
Folliculitis 78.11 39.55 228 38578 204125 90385516
Helicobacter infection 76.31 39.55 242 38564 226608 90363033
Duodenal ulcer perforation 76.22 39.55 238 38568 221050 90368591
Injury 75.25 39.55 220 38586 197129 90392512
Wound 74.15 39.55 291 38515 302689 90286952
Arthritis 72.10 39.55 195 38611 167120 90422521
Weight decreased 70.06 39.55 335 38471 379575 90210066
Contusion 68.67 39.55 250 38556 250966 90338675
Spinal fusion surgery 67.89 39.55 50 38756 12233 90577408
Death 67.26 39.55 58 38748 456493 90133148
Oedema peripheral 65.77 39.55 251 38555 257664 90331977
Spondylitis 63.64 39.55 51 38755 14127 90575514
C-reactive protein abnormal 62.57 39.55 156 38650 127273 90462368
Somnolence 62.29 39.55 8 38798 209076 90380565
Psoriatic arthropathy 62.20 39.55 227 38579 228108 90361533
Weight fluctuation 62.17 39.55 58 38748 19691 90569950
Injection site pain 61.81 39.55 3 38803 173696 90415945
Liver injury 60.14 39.55 185 38621 170382 90419259
Urticaria 59.25 39.55 278 38528 312456 90277185
Sepsis 58.39 39.55 5 38801 179809 90409832
Fatigue 57.43 39.55 277 38529 1153746 89435895
Knee arthroplasty 56.67 39.55 116 38690 83066 90506575
Night sweats 56.38 39.55 151 38655 128615 90461026
Disability 56.30 39.55 78 38728 40667 90548974
Drug tolerance decreased 56.06 39.55 69 38737 32061 90557580
Obesity 55.89 39.55 133 38673 105374 90484267
Discomfort 55.01 39.55 248 38558 274087 90315554
Anti-cyclic citrullinated peptide antibody positive 54.53 39.55 223 38583 236210 90353431
Facet joint syndrome 54.26 39.55 126 38680 98263 90491378
COVID-19 54.00 39.55 5 38801 168838 90420803
Myalgia 53.90 39.55 6 38800 175119 90414522
Pericarditis 53.26 39.55 243 38563 269908 90319733
Muscular weakness 52.56 39.55 201 38605 206465 90383176
Lung disorder 52.30 39.55 162 38644 149721 90439920
Memory impairment 51.95 39.55 194 38612 197050 90392591
Hand deformity 50.77 39.55 256 38550 296106 90293535
Dehydration 50.06 39.55 11 38795 194436 90395205
Overdose 49.56 39.55 5 38801 157704 90431937
Musculoskeletal stiffness 48.60 39.55 253 38553 296279 90293362
Mobility decreased 48.28 39.55 224 38582 250510 90339131
Hepatic enzyme increased 48.02 39.55 291 38515 360445 90229196
Chest discomfort 47.34 39.55 3 38803 138362 90451279
Nausea 46.10 39.55 283 38523 1110033 89479608
Bursitis 45.65 39.55 142 38664 131512 90458129
Blister 45.60 39.55 223 38583 254775 90334866
Hyponatraemia 45.37 39.55 3 38803 133535 90456106
Weight increased 45.20 39.55 320 38486 417607 90172034
Renal failure 44.35 39.55 3 38803 131004 90458637
Upper respiratory tract infection 44.12 39.55 138 38668 128180 90461461
Asthma 43.46 39.55 212 38594 241948 90347693
Tremor 42.97 39.55 7 38799 153166 90436475
Disease progression 42.10 39.55 8 38798 156607 90433034
Chills 41.96 39.55 4 38802 131977 90457664
Dyspepsia 41.86 39.55 182 38624 197978 90391663
Cerebrovascular accident 41.32 39.55 3 38803 123530 90466111
Pemphigus 41.17 39.55 260 38546 326604 90263037
Drug-induced liver injury 40.63 39.55 107 38699 90211 90499430
Seizure 40.59 39.55 8 38798 152621 90437020
Atrial fibrillation 40.06 39.55 5 38801 133606 90456035

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Frequent bowel movements 298.68 46.14 117 6812 21290 42593116
Colitis ulcerative 285.95 46.14 120 6809 26055 42588351
Steroid dependence 273.64 46.14 82 6847 6640 42607766
Catarrh 234.91 46.14 71 6858 5915 42608491
Burns second degree 233.64 46.14 71 6858 6025 42608381
Impaired work ability 230.11 46.14 83 6846 12008 42602398
Electrocardiogram QT prolonged 222.32 46.14 122 6807 47823 42566583
Bronchiectasis 218.30 46.14 89 6840 17930 42596476
Hypopnoea 215.68 46.14 71 6858 7811 42606595
Parosmia 213.35 46.14 70 6859 7621 42606785
Intentional product use issue 213.15 46.14 137 6792 71696 42542710
Gingival pain 210.47 46.14 71 6858 8423 42605983
Systemic lupus erythematosus 203.98 46.14 71 6858 9253 42605153
Impaired quality of life 202.95 46.14 79 6850 14098 42600308
Rhinitis 193.87 46.14 73 6856 11904 42602502
Haematochezia 184.59 46.14 116 6813 58320 42556086
Cardiac murmur 182.18 46.14 71 6858 12704 42601702
Rectal haemorrhage 168.09 46.14 103 6826 49503 42564903
Alcohol poisoning 166.90 46.14 58 6871 7516 42606890
Swollen tongue 144.45 46.14 70 6859 21161 42593245
Medication error 144.31 46.14 81 6848 33073 42581333
Tinnitus 143.32 46.14 77 6852 28861 42585545
Nightmare 139.33 46.14 72 6857 24940 42589466
Arthritis 139.03 46.14 86 6843 41979 42572427
Stress 137.59 46.14 87 6842 44125 42570281
Migraine 135.38 46.14 71 6858 25343 42589063
Loss of personal independence in daily activities 130.50 46.14 88 6841 49728 42564678
Accidental overdose 122.68 46.14 69 6860 28261 42586145
Inappropriate schedule of product administration 121.16 46.14 110 6819 95792 42518614
Tubulointerstitial nephritis 121.02 46.14 71 6858 31477 42582929
Eczema 115.93 46.14 71 6858 34015 42580391
Vertigo 115.43 46.14 71 6858 34276 42580130
Dysgeusia 113.19 46.14 70 6859 34119 42580287
Palpitations 105.76 46.14 78 6851 50719 42563687
Off label use 95.96 46.14 272 6657 638063 41976343
Hepatotoxicity 94.81 46.14 56 6873 25111 42589295
Deep vein thrombosis 90.76 46.14 85 6844 76872 42537534
Abdominal discomfort 84.68 46.14 81 6848 75174 42539232
Adverse drug reaction 81.31 46.14 59 6870 37375 42577031
Product use in unapproved indication 78.39 46.14 121 6808 184335 42430071
Condition aggravated 74.00 46.14 143 6786 260611 42353795
Drug resistance 69.91 46.14 52 6877 34196 42580210
Weight decreased 65.09 46.14 119 6810 207829 42406577
Cerebrovascular accident 62.64 46.14 78 6851 97082 42517324
COVID-19 59.18 46.14 83 6846 115865 42498541
Tuberculosis 53.11 46.14 28 6901 10071 42604335
Pulmonary embolism 48.65 46.14 77 6852 119535 42494871
Depression 48.52 46.14 74 6855 111289 42503117

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Colitis ulcerative 646.08 34.24 366 35040 76997 110476896
Frequent bowel movements 564.56 34.24 326 35080 71064 110482829
Rectal haemorrhage 364.61 34.24 304 35102 119529 110434364
Porphyria acute 348.52 34.24 153 35253 18627 110535266
Dislocation of vertebra 236.81 34.24 157 35249 43564 110510329
Retinitis 209.53 34.24 130 35276 32197 110521696
X-ray abnormal 209.15 34.24 138 35268 37979 110515914
Adjustment disorder with depressed mood 207.74 34.24 145 35261 43738 110510155
Steroid dependence 207.21 34.24 84 35322 8385 110545508
Grip strength 204.37 34.24 85 35321 9056 110544837
Lupus-like syndrome 177.41 34.24 128 35278 40664 110513229
Catarrh 176.87 34.24 72 35334 7263 110546630
Burns second degree 176.57 34.24 73 35333 7660 110546233
Sleep disorder due to general medical condition, insomnia type 156.73 34.24 181 35225 105462 110448431
Lupus vulgaris 146.60 34.24 106 35300 33777 110520116
Hypopnoea 146.54 34.24 72 35334 11308 110542585
Fall 142.92 34.24 14 35392 603468 109950425
Electrocardiogram QT prolonged 140.78 34.24 174 35232 108786 110445107
Breast cancer stage III 140.57 34.24 149 35257 78968 110474925
Arthritis 138.86 34.24 216 35190 167370 110386523
Lip dry 137.71 34.24 165 35241 99918 110453975
Parosmia 133.71 34.24 71 35335 13109 110540784
Haematochezia 132.69 34.24 174 35232 115350 110438543
Wound infection 132.66 34.24 159 35247 96306 110457587
Bone erosion 127.29 34.24 111 35295 46260 110507633
Medication error 126.16 34.24 162 35244 105204 110448689
Autoimmune disorder 124.70 34.24 128 35278 65355 110488538
Gingival pain 124.60 34.24 72 35334 15664 110538229
Acute kidney injury 124.40 34.24 26 35380 635404 109918489
Alcohol poisoning 121.94 34.24 59 35347 8961 110544932
Exostosis 120.13 34.24 107 35299 45849 110508044
Peripheral venous disease 117.88 34.24 140 35266 83977 110469916
Laryngitis 117.37 34.24 102 35304 42309 110511584
Systemic lupus erythematosus 115.66 34.24 253 35153 254085 110299808
Toxicity to various agents 114.12 34.24 11 35395 480544 110073349
Impaired work ability 112.80 34.24 82 35324 26337 110527556
Drug interaction 112.32 34.24 14 35392 500169 110053724
Foot deformity 111.37 34.24 105 35301 48375 110505518
Feeling hot 110.52 34.24 141 35265 90965 110462928
Rheumatic fever 109.99 34.24 164 35242 122415 110431478
Hypotension 109.86 34.24 18 35388 523831 110030062
Bronchiectasis 107.57 34.24 91 35315 36402 110517491
Rhinitis 105.52 34.24 74 35332 22471 110531422
Intentional product use issue 104.19 34.24 239 35167 247667 110306226
Pancreatitis 101.43 34.24 137 35269 93396 110460497
Death 100.77 34.24 49 35357 698820 109855073
Amnesia 100.31 34.24 145 35261 105263 110448630
Liver disorder 99.68 34.24 170 35236 142073 110411820
Sleep disorder due to a general medical condition 99.46 34.24 102 35304 52010 110501883
Ear infection 98.97 34.24 111 35295 62621 110491272
Cardiac murmur 97.41 34.24 73 35333 24555 110529338
Swollen joint count 97.34 34.24 50 35356 8624 110545269
Muscle injury 96.99 34.24 167 35239 140640 110413253
Road traffic accident 96.79 34.24 144 35262 107254 110446639
Delirium 96.77 34.24 163 35243 134862 110419031
Laboratory test abnormal 96.56 34.24 93 35313 43986 110509907
C-reactive protein abnormal 96.20 34.24 159 35247 129536 110424357
Type 2 diabetes mellitus 95.40 34.24 189 35217 177043 110376850
Osteoporosis 95.03 34.24 128 35278 87024 110466869
Deep vein thrombosis postoperative 93.68 34.24 105 35301 59186 110494707
Neutropenia 93.23 34.24 7 35399 374613 110179280
Weight decreased 93.09 34.24 345 35061 467712 110086181
Impaired quality of life 92.91 34.24 77 35329 29940 110523953
Hepatic cirrhosis 92.19 34.24 111 35295 67515 110486378
Cough 92.14 34.24 18 35388 461623 110092270
Lower limb fracture 90.41 34.24 116 35290 75232 110478661
Sciatica 89.22 34.24 128 35278 92271 110461622
Migraine 86.37 34.24 178 35228 171474 110382419
Night sweats 85.91 34.24 154 35252 133829 110420064
Facet joint syndrome 84.64 34.24 128 35278 96700 110457193
Adverse drug reaction 84.52 34.24 134 35272 105425 110448468
Drug tolerance decreased 83.90 34.24 70 35336 27470 110526423
Pulmonary fibrosis 83.73 34.24 131 35275 101911 110451982
Joint range of motion decreased 83.24 34.24 144 35262 121688 110432205
White blood cell count increased 83.21 34.24 127 35279 96715 110457178
Duodenal ulcer perforation 82.13 34.24 178 35228 177522 110376371
Rheumatoid factor positive 81.47 34.24 149 35257 131491 110422402
Obesity 81.43 34.24 137 35269 113214 110440679
Ill-defined disorder 79.31 34.24 163 35243 156690 110397203
Walking aid user 79.02 34.24 65 35341 25010 110528883
Depression 77.93 34.24 251 35155 317084 110236809
Product dose omission issue 77.33 34.24 7 35399 321775 110232118
Abdominal discomfort 77.16 34.24 289 35117 393569 110160324
Bursitis 76.57 34.24 144 35262 129774 110424119
Urinary tract infection 76.04 34.24 8 35398 326274 110227619
Helicobacter infection 75.99 34.24 175 35231 181702 110372191
Fibromyalgia 74.24 34.24 167 35239 170742 110383151
Blood cholesterol increased 74.14 34.24 175 35231 184610 110369283
Swollen joint count increased 73.69 34.24 111 35295 83550 110470343
Discomfort 73.14 34.24 191 35215 214516 110339377
Weight fluctuation 73.14 34.24 59 35347 22086 110531807
Anti-cyclic citrullinated peptide antibody positive 70.48 34.24 170 35236 181814 110372079
Grip strength decreased 70.09 34.24 106 35300 80068 110473825
Lung disorder 69.52 34.24 168 35238 179879 110374014
Hand deformity 69 34.24 189 35217 218317 110335576
Loss of personal independence in daily activities 69.00 34.24 150 35256 149870 110404023
Nightmare 68.66 34.24 73 35333 38790 110515103
Folliculitis 68.59 34.24 160 35246 167493 110386400
Sepsis 66.92 34.24 12 35394 327334 110226559
Osteoarthritis 65.85 34.24 166 35240 182457 110371436
Joint dislocation 65.38 34.24 67 35339 34123 110519770
Hepatic enzyme increased 64.94 34.24 238 35168 320654 110233239
Drug resistance 64.83 34.24 85 35321 56289 110497604
Impaired healing 63.95 34.24 172 35234 196545 110357348
Hypercholesterolaemia 62.87 34.24 108 35298 90729 110463164
White blood cell count decreased 60.92 34.24 3 35403 229387 110324506
Irritable bowel syndrome 59.97 34.24 150 35256 164065 110389828
Contusion 58.54 34.24 186 35220 233175 110320718
Musculoskeletal pain 58.46 34.24 159 35247 182864 110371029
Back pain 58.15 34.24 23 35383 370973 110182920
Overdose 56.39 34.24 5 35401 233789 110320104
Tinnitus 55.71 34.24 82 35324 60458 110493435
Maternal exposure timing unspecified 55.05 34.24 49 35357 20964 110532929
Gastrointestinal disorder 54.56 34.24 186 35220 241766 110312127
Visual impairment 53.57 34.24 127 35279 134301 110419592
Prescribed overdose 52.74 34.24 98 35308 87483 110466410
Atrial fibrillation 52.55 34.24 6 35400 229636 110324257
Nausea 52.47 34.24 211 35195 1235479 109318414
Accidental overdose 51.78 34.24 73 35333 51761 110502132
Renal failure 51.65 34.24 6 35400 226568 110327325
Dehydration 51.49 34.24 13 35393 279498 110274395
Adverse event 51.40 34.24 110 35296 108699 110445194
Pemphigus 51.07 34.24 168 35238 214402 110339491
Respiratory disorder 49.56 34.24 85 35321 71297 110482596
Wound 49.20 34.24 176 35230 234261 110319632
Hyponatraemia 49.03 34.24 6 35400 217647 110336246
Inappropriate schedule of product administration 48.07 34.24 159 35247 203478 110350415
Tubulointerstitial nephritis 47.76 34.24 72 35334 54212 110499681
Glossodynia 47.73 34.24 168 35238 221836 110332057
Proctitis 47.41 34.24 41 35365 16886 110537007
Lower respiratory tract infection 47.22 34.24 178 35228 242928 110310965
Pregnancy 46.74 34.24 69 35337 50998 110502895
Injection site pain 45.17 34.24 3 35403 177919 110375974
Psoriatic arthropathy 44.11 34.24 151 35255 196610 110357283
Disease progression 43.71 34.24 12 35394 244022 110309871
Chills 43.55 34.24 5 35401 190575 110363318
Hyperhidrosis 42.59 34.24 5 35401 187293 110366600
Myocardial infarction 41.58 34.24 6 35400 192077 110361816
Vaginal flatulence 41.47 34.24 33 35373 12111 110541782
Gastrointestinal haemorrhage 41.41 34.24 3 35403 165515 110388378
Swollen tongue 40.75 34.24 71 35335 60291 110493602
Stomatitis 40.74 34.24 183 35223 270059 110283834
Blister 40.50 34.24 162 35244 227214 110326679
Red blood cell sedimentation rate increased 40.29 34.24 82 35324 78220 110475673
Pancytopenia 40.08 34.24 9 35397 209604 110344289
Pleural effusion 39.77 34.24 5 35401 177704 110376189
Dry mouth 39.32 34.24 147 35259 199801 110354092
Therapeutic reaction time decreased 38.74 34.24 23 35383 5256 110548637
Chest discomfort 38.65 34.24 5 35401 173843 110380050
Hepatotoxicity 38.24 34.24 71 35335 63329 110490564
Eczema 37.55 34.24 76 35330 72217 110481676
Injury 36.25 34.24 132 35274 177133 110376760
Stress 36.13 34.24 94 35312 105254 110448639
Tremor 36.11 34.24 10 35396 202222 110351671
Condition aggravated 35.85 34.24 376 35030 734460 109819433
Inflammation 35.47 34.24 139 35267 193099 110360794
Pericarditis 35.01 34.24 151 35255 218963 110334930
Platelet count decreased 34.93 34.24 15 35391 230428 110323465
Female genital tract fistula 34.57 34.24 34 35372 16485 110537408
Myalgia 34.47 34.24 14 35392 222367 110331526
Cardiac failure congestive 34.40 34.24 4 35402 150996 110402897

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J04AA01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Aminosalicylic acid and derivatives
ATC J04AA02 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Aminosalicylic acid and derivatives
ATC J04AA03 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Aminosalicylic acid and derivatives
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000995 Antitubercular Agents
CHEBI has role CHEBI:33231 antitubercular agent

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Acute tuberculosis indication 25629007
Pulmonary tuberculosis indication 154283005 DOID:2957
Crohn's disease off-label use 34000006
Ulcerative colitis off-label use 64766004 DOID:8577
Goiter contraindication 3716002 DOID:12176
Peptic ulcer contraindication 13200003 DOID:750
Hypokalemia contraindication 43339004
Crystalluria contraindication 46784006
Chronic heart failure contraindication 48447003
Acidosis contraindication 51387008
Duodenal ulcer disease contraindication 51868009 DOID:1724
Kidney disease contraindication 90708001 DOID:557
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Cobalamin deficiency contraindication 190634004
Disease of liver contraindication 235856003 DOID:409
Gastric ulcer contraindication 397825006 DOID:10808




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.71 acidic
pKa2 12.94 acidic
pKa3 2.33 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Cyclooxygenase Enzyme INHIBITOR CHEMBL CHEMBL
Tyrosine-protein phosphatase non-receptor type 1 Enzyme Kd 2.92 CHEMBL
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Kinase WOMBAT-PK

External reference:

IDSource
4018852 VUID
N0000180192 NUI
D00162 KEGG_DRUG
133-09-5 SECONDARY_CAS_RN
4018852 VANDF
4018919 VANDF
C0030125 UMLSCUI
CHEBI:27565 CHEBI
CHEMBL1169 ChEMBL_ID
CHEMBL1200584 ChEMBL_ID
CHEMBL2105983 ChEMBL_ID
CHEMBL2096646 ChEMBL_ID
CHEMBL1200966 ChEMBL_ID
D010131 MESH_DESCRIPTOR_UI
DB00233 DRUGBANK_ID
6018-19-5 SECONDARY_CAS_RN
5B2658E0N2 UNII
4649 PUBCHEM_CID
7833 RXNORM
10002 MMSL
4176 MMSL
d01099 MMSL
d04226 MMSL
002845 NDDF
002846 NDDF
002847 NDDF
20231007 SNOMEDCT_US
255666002 SNOMEDCT_US
417238004 SNOMEDCT_US
65222005 SNOMEDCT_US
BHA PDB_CHEM_ID
13652 IUPHAR_LIGAND_ID

Pharmaceutical products:

None