aminobenzoic acid Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2049 150-13-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • 4-aminobenzoic acid
  • aminobenzoate potassium
  • p-aminobenzoic acid
  • 4-aminobenzenecarboxylic acid
  • 4-carboxy phenyl aniline
  • aminobenzoic acid
  • 4-Aminobenzoate
An aminobenzoic acid isomer that combines with pteridine and GLUTAMIC ACID to form FOLIC ACID. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in SUNSCREENS.
  • Molecular weight: 137.14
  • Formula: C7H7NO2
  • CLOGP: 0.98
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 63.32
  • ALOGS: -1.49
  • ROTB: 1

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC D02BA01 DERMATOLOGICALS
EMOLLIENTS AND PROTECTIVES
PROTECTIVES AGAINST UV-RADIATION
Protectives against UV-radiation for topical use
ATC D11AX23 DERMATOLOGICALS
OTHER DERMATOLOGICAL PREPARATIONS
OTHER DERMATOLOGICAL PREPARATIONS
Other dermatologicals
FDA CS M0022792 Vitamin B Complex
FDA EPC N0000175714 Vitamin B Complex Member
CHEBI has role CHEBI:75772 baker's yeast metabolite
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:76971 e.coli metabolites
CHEBI has role CHEBI:50904 allergene

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Induratio penis plastica indication 1335005 DOID:8616
Pemphigus indication 65172003 DOID:9182
Systemic sclerosis indication 89155008 DOID:418
Morphea indication 201049004
Dermatomyositis indication 396230008 DOID:10223
Anorexia nervosa contraindication 56882008 DOID:8689
Kidney disease contraindication 90708001 DOID:557

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.65 acidic
pKa2 2.29 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Carbonic anhydrase 1 Enzyme Ki 5.08 CHEMBL
Carbonic anhydrase 2 Enzyme Ki 5.09 CHEMBL
Acetylcholinesterase Enzyme IC50 7.45 CHEMBL
Dihydropteroate synthase Enzyme Kd 5.25 CHEMBL

External reference:

IDSource
41KZS5432U UNII
4019089 VUID
N0000147349 NUI
D02456 KEGG_DRUG
138-84-1 SECONDARY_CAS_RN
4018418 VANDF
4019089 VANDF
C1703206 UMLSCUI
CHEBI:17836 CHEBI
PAB PDB_CHEM_ID
CHEMBL542 ChEMBL_ID
CHEMBL1564391 ChEMBL_ID
4876 PUBCHEM_CID
DB02362 DRUGBANK_ID
D010129 MESH_DESCRIPTOR_UI
142141 RXNORM
41627 MMSL
5231 MMSL
5335 MMSL
5490 MMSL
NOCODE MMSL
d00331 MMSL
d04184 MMSL
001006 NDDF
001007 NDDF
001966 NDDF
002325 NDDF
002326 NDDF
002338 NDDF
329290002 SNOMEDCT_US
373489001 SNOMEDCT_US
395838004 SNOMEDCT_US
39707000 SNOMEDCT_US

Pharmaceutical products:

None