pamabrom 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2047 10381-75-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • 8-bromotheophylline
  • bromotheophylline
  • pamabrom
  • predema
  • Molecular weight: 259.06
  • Formula: C7H7BrN4O2
  • CLOGP: 0.93
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 69.30
  • ALOGS: -1.82
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Ocular hypertension contraindication 4210003 DOID:9282
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Hepatic failure contraindication 59927004
Blood coagulation disorder contraindication 64779008 DOID:1247
Poisoning by acetaminophen contraindication 70273001
Chronic idiopathic constipation contraindication 82934008
Disease of liver contraindication 235856003 DOID:409
Bladder outflow obstruction contraindication 236645006
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Vitamin K Deficiency Induced Hypoprothrombinemia contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.87 acidic
pKa2 2.43 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Adenosine receptor A1 GPCR Ki 4.99 CHEMBL

External reference:

IDSource
4019460 VUID
N0000179338 NUI
D08962 KEGG_DRUG
4019460 VANDF
C0135166 UMLSCUI
CHEMBL316160 ChEMBL_ID
CHEMBL2104825 ChEMBL_ID
C069987 MESH_SUPPLEMENTAL_RECORD_UI
11806 PUBCHEM_CID
UA8U0KJM72 UNII
DB14018 DRUGBANK_ID
1546386 RXNORM
5225 MMSL
d03585 MMSL
002318 NDDF
116552006 SNOMEDCT_US
398981003 SNOMEDCT_US
606-04-2 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Midol Teen HUMAN OTC DRUG LABEL 2 0280-8030 TABLET, COATED 25 mg ORAL OTC monograph not final 15 sections
Pamabrom HUMAN OTC DRUG LABEL 1 0363-0795 CAPSULE, LIQUID FILLED 50 mg ORAL unapproved drug other 8 sections
Fem Relief HUMAN OTC DRUG LABEL 2 0498-7000 TABLET 25 mg ORAL OTC monograph not final 15 sections
Fem Relief HUMAN OTC DRUG LABEL 2 0498-7001 TABLET 25 mg ORAL OTC monograph not final 15 sections
Menstrual Relief HUMAN OTC DRUG LABEL 3 11673-967 TABLET, FILM COATED 25 mg ORAL OTC monograph not final 16 sections
menstrual pain reliefmaximum strength HUMAN OTC DRUG LABEL 3 11822-6790 TABLET, FILM COATED 25 mg ORAL OTC monograph not final 16 sections
Pain Aid PMF HUMAN OTC DRUG LABEL 2 35418-710 TABLET 25 mg ORAL OTC monograph not final 9 sections
Menstrual ReliefMaximum Strength HUMAN OTC DRUG LABEL 3 36800-979 TABLET, FILM COATED 25 mg ORAL OTC monograph not final 16 sections
Leader Premenstrual HUMAN OTC DRUG LABEL 3 37205-339 CAPSULE 25 mg ORAL OTC monograph not final 16 sections
Pain Aid PMF HUMAN OTC DRUG LABEL 2 42961-046 TABLET 25 mg ORAL OTC monograph not final 9 sections
Green Guard PMS Relief HUMAN OTC DRUG LABEL 2 47682-016 TABLET, FILM COATED 25 mg ORAL OTC monograph not final 15 sections
Green Guard PMS Relief HUMAN OTC DRUG LABEL 2 47682-016 TABLET, FILM COATED 25 mg ORAL OTC monograph not final 15 sections
Medi First Cramp HUMAN OTC DRUG LABEL 2 47682-810 TABLET, FILM COATED 25 mg ORAL OTC monograph not final 15 sections
Medi First Cramp HUMAN OTC DRUG LABEL 2 47682-810 TABLET, FILM COATED 25 mg ORAL OTC monograph not final 15 sections
Medi First Plus Cramp HUMAN OTC DRUG LABEL 2 47682-910 TABLET, FILM COATED 25 mg ORAL OTC monograph not final 15 sections
Medi First Plus Cramp HUMAN OTC DRUG LABEL 2 47682-910 TABLET, FILM COATED 25 mg ORAL OTC monograph not final 15 sections
Unishield Cramp HUMAN OTC DRUG LABEL 2 49314-8103 TABLET, FILM COATED 25 mg ORAL OTC monograph not final 17 sections
Unishield Cramp HUMAN OTC DRUG LABEL 2 49314-8103 TABLET, FILM COATED 25 mg ORAL OTC monograph not final 17 sections
Menstrual ReliefMaximum Strength HUMAN OTC DRUG LABEL 3 50844-679 TABLET, FILM COATED 25 mg ORAL OTC monograph not final 16 sections
Femadrine HUMAN OTC DRUG LABEL 2 51532-0700 TABLET 25 1 ORAL OTC monograph not final 11 sections
BackAidMax HUMAN OTC DRUG LABEL 2 52389-153 TABLET, FILM COATED 25 mg ORAL OTC monograph not final 16 sections
DiurexMax HUMAN OTC DRUG LABEL 1 52389-249 TABLET, FILM COATED 50 mg ORAL unapproved drug other 14 sections
Diurex HUMAN OTC DRUG LABEL 1 52389-325 CAPSULE 50 mg ORAL unapproved drug other 12 sections
DiurexMax HUMAN OTC DRUG LABEL 1 52389-349 TABLET, FILM COATED 50 mg ORAL Export only 1 sections
Menstrual ReliefMaximum Strength HUMAN OTC DRUG LABEL 3 55301-679 TABLET, FILM COATED 25 mg ORAL OTC monograph not final 16 sections
Menstrual ReliefMaximum Strength HUMAN OTC DRUG LABEL 3 55301-679 TABLET, FILM COATED 25 mg ORAL OTC monograph not final 16 sections
Menstrual Pain ReliefMaximum Strength HUMAN OTC DRUG LABEL 3 55319-679 TABLET, FILM COATED 25 mg ORAL OTC monograph not final 16 sections
Menstrual ReliefMaximum Strength HUMAN OTC DRUG LABEL 3 55319-979 TABLET, FILM COATED 25 mg ORAL OTC monograph not final 16 sections
Menstrual Pain ReliefMaximum Strength / Multi Symptom HUMAN OTC DRUG LABEL 3 55910-967 TABLET, FILM COATED 25 mg ORAL OTC monograph not final 16 sections
PMS ReliefMaximum Strength HUMAN OTC DRUG LABEL 3 59779-879 TABLET, FILM COATED 25 mg ORAL OTC monograph not final 16 sections