Stem definition | Drug id | CAS RN |
---|---|---|
antibiotics, protein-synthesis inhibitors, tetracycline derivatives | 2041 | 79-57-2 |
Dose | Unit | Route |
---|---|---|
1 | g | O |
1 | g | P |
Property | Value | Reference |
---|---|---|
MRTD (Maximum Recommended Therapeutic Daily Dose) | 72.32 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 4 | Bocci G, Oprea TI, Benet LZ |
BA (Bioavailability) | 58 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 1.70 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 2 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.90 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 10 hours | Lombardo F, Berellini G, Obach RS |
S (Water solubility) | 0.20 mg/mL | Bocci G, Oprea TI, Benet LZ |
Date | Agency | Company | Orphan |
---|---|---|---|
Sept. 8, 1964 | FDA | PFIZER |
None
None
None
None
Source | Code | Description |
---|---|---|
ATC | A01AB25 | ALIMENTARY TRACT AND METABOLISM STOMATOLOGICAL PREPARATIONS STOMATOLOGICAL PREPARATIONS Antiinfectives and antiseptics for local oral treatment |
ATC | D06AA03 | DERMATOLOGICALS ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE ANTIBIOTICS FOR TOPICAL USE Tetracycline and derivatives |
ATC | G01AA07 | GENITO URINARY SYSTEM AND SEX HORMONES GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS Antibiotics |
ATC | J01AA06 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE TETRACYCLINES Tetracyclines |
ATC | J01AA56 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE TETRACYCLINES Tetracyclines |
ATC | S01AA04 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Antibiotics |
FDA CS | M0021223 | Tetracyclines |
FDA EPC | N0000175505 | Tetracycline-class Antimicrobial |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Trachoma | indication | 2576002 | DOID:11265 |
Actinomycotic infection | indication | 11817007 | DOID:8478 |
Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
Gingivostomatitis | indication | 20607006 | |
Acute gonococcal cervicitis | indication | 20943002 | DOID:10615 |
Granuloma inguinale | indication | 28867007 | DOID:9113 |
Acute gonococcal urethritis | indication | 29864006 | |
Acute gonococcal epididymo-orchitis | indication | 30168008 | DOID:10802 |
Bronchitis | indication | 32398004 | DOID:6132 |
Sinusitis | indication | 36971009 | |
Gonorrhea of rectum | indication | 42746002 | |
Acute gonococcal endometritis | indication | 65295003 | DOID:7527 |
Urinary tract infectious disease | indication | 68566005 | |
Yaws | indication | 70647001 | DOID:10371 |
Gonorrhea of pharynx | indication | 74372003 | |
Rickettsialpox | indication | 75096007 | DOID:11103 |
Ornithosis | indication | 75116005 | DOID:11262 |
Brucellosis | indication | 75702008 | DOID:11077 |
Syphilis | indication | 76272004 | |
Bacterial conjunctivitis | indication | 128350005 | DOID:9700 |
Rocky Mountain spotted fever | indication | 186772009 | |
Q fever | indication | 186788009 | DOID:11100 |
Lymphogranuloma venereum | indication | 186946009 | DOID:13819 |
Pneumonia | indication | 233604007 | DOID:552 |
Inclusion conjunctivitis | indication | 266109000 | |
Infective otitis media | indication | 312218008 | |
Bacterial keratitis | indication | 314557000 | |
Pharyngitis | indication | 405737000 | DOID:2275 |
Anthrax | indication | 409498004 | DOID:7427 |
Relapsing fever | indication | 420079008 | DOID:13034 |
Chlamydia trachomatis infection of genital structure | indication | 428015005 | |
Rectal Chlamydia Trachomatis Infection | indication | ||
Typhus Infections | indication | ||
Superficial Ocular Infection | indication | ||
Tularemia | off-label use | 19265001 | |
Enterocolitis | off-label use | 43752006 | |
Pneumonia due to Mycoplasma pneumoniae | off-label use | 46970008 | |
Plague | off-label use | 58750007 | DOID:3482 |
Cholangitis | off-label use | 82403002 | DOID:9446 |
Chlamydial infection | off-label use | 105629000 | |
Infectious disease of abdomen | off-label use | 128070006 | |
Ocular rosacea | off-label use | 200933006 | |
Complete atrioventricular block | contraindication | 27885002 | |
Shock | contraindication | 27942005 | |
Hypovolemia | contraindication | 28560003 | |
Glomerulonephritis | contraindication | 36171008 | DOID:2921 |
Acute hepatitis | contraindication | 37871000 | |
Hypokalemia | contraindication | 43339004 | |
Uremia | contraindication | 44730006 | DOID:4676 |
Stokes-Adams syndrome | contraindication | 46935006 | |
Chronic heart failure | contraindication | 48447003 | |
Atrial fibrillation | contraindication | 49436004 | DOID:0060224 |
Sinus bradycardia | contraindication | 49710005 | |
Acute nephropathy | contraindication | 58574008 | |
Wolff-Parkinson-White pattern | contraindication | 74390002 | DOID:384 |
Decreased respiratory function | contraindication | 80954004 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Anemia due to enzyme deficiency | contraindication | 111577008 | |
Deficiency of glucose-6-phosphate dehydrogenase | contraindication | 124134002 | DOID:2862 |
Partial atrioventricular block | contraindication | 195039008 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Pregnancy, function | contraindication | 289908002 | |
Hypoxia | contraindication | 389086002 | |
Pseudomembranous enterocolitis | contraindication | 397683000 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Reduced Hepatic Blood Flow | contraindication | ||
Lidocaine Toxicity | contraindication |
Species | Use | Relation |
---|---|---|
Bees | American foulbrood caused by Paenibacillus larvae | Indication |
Bees | European foulbrood caused by Streptococcus pluton | Indication |
Cats | Bacterial pneumonia caused by Brucella bronchiseptica | Indication |
Cats | Tonsillitis caused by Streptococcus hemolyticus | Indication |
Cats | Bacterial enteritis caused by Escherichia coli | Indication |
Cats | Urinary tract infections caused by Escherichia coli | Indication |
Cats | Wound infections caused by Staphylococcus aureus | Indication |
Cattle | Pneumonia and shipping fever complex associated with Pasteurella species | Indication |
Cattle | Pneumonia and shipping fever complex associated with Actinobacillus pleuropneumoniae | Indication |
Cattle | Pneumonia and shipping fever complex associated with Klebsiella species | Indication |
Cattle | Foot-rot caused by Spherophorus necrophorus | Indication |
Cattle | Diphtheria caused by Spherophorus necrophorus | Indication |
Cattle | Bacterial enteritis caused by Salmonella typhimurium | Indication |
Cattle | Bacterial enteritis caused by Escherichia coli | Indication |
Cattle | Wooden tongue caused by Actinobacillus lignieresi | Indication |
Cattle | Leptospirosis caused by Leptospira pomona | Indication |
Cattle | Wound infections caused by staphylococcal and streptococcal organisms | Indication |
Cattle | Acute metritis caused by staphylococcal and streptococcal organisms | Indication |
Cattle | Reduction of the incidence of liver abscesses | Indication |
Cattle | Anaplasmosis caused by Anaplasma marginale | Indication |
Cattle | Anthrax caused by Bacillus anthracis | Indication |
Cattle | Bovine keratoconjunctivitis (pinkeye) caused by Moraxella bovis | Indication |
Chickens | Air sacculitis (air-sac disease chronic respiratory disease) caused by Mycoplasma gallisepticum | Indication |
Chickens | Air sacculitis (air-sac disease chronic respiratory disease) caused by Escherichia coli | Indication |
Chickens | Cholera caused by Pasteurella multocida | Indication |
Chickens | Infectious sinusitis caused by Mycoplasma gallisepticum | Indication |
Chickens | Infectious synovitis caused by Mycoplasma synoviae | Indication |
Dogs | Bacterial pneumonia caused by Brucella bronchiseptica | Indication |
Dogs | Tonsillitis caused by Streptococcus hemolyticus | Indication |
Dogs | Bacterial enteritis caused by Escherichia coli | Indication |
Dogs | Urinary tract infections caused by Staphylococcus species | Indication |
Dogs | Urinary tract infections caused by Escherichia coli | Indication |
Dogs | Wound infections caused by Staphylococcus aureus | Indication |
Fish - Catfish | Bacterial hemorrhagic septicemia caused by Aeromonas hydrophila | Indication |
Fish - Catfish | Pseudomonas disease | Indication |
Fish - Finfish | Skeletal marking of finfish fry and fingerlings | Indication |
Fish - Freshwater-reared Oncorhynchus mykiss | Columnaris disease associated with Flavobacterium columnare | Indication |
Fish - Freshwater-reared Salmonids | Coldwater disease associated with Flavobacterium psychrophilum | Indication |
Fish - Pacific Salmon | Marking of skeletal tissue | Indication |
Fish - Salmonids | Ulcer disease caused by Haemophilus piscium | Indication |
Fish - Salmonids | Furunculosis caused by Aeromonas salmonicida | Indication |
Fish - Salmonids | Bacterial hemorrhagic septicemia caused by Aeromonas hydrophila | Indication |
Fish - Salmonids | Pseudomonas disease | Indication |
Horses | No Use Class Stated Or Implied | Indication |
Lobsters | Gaffkemia caused by Aerococcus viridans | Indication |
Sheep | Bacterial enteritis caused by Escherichia coli | Indication |
Sheep | Bacterial pneumonia caused by Pasteurella multocida | Indication |
Swine | Leptospirosis caused by Leptospira pomona | Indication |
Swine | Bacterial enteritis caused by Escherichia coli | Indication |
Swine | Bacterial enteritis caused by Escherichia coli | Indication |
Swine | Bacterial pneumonia caused by Pasteurella multocida | Indication |
Swine | Bacterial enteritis caused by Salmonella choleraesuis | Indication |
Turkeys | Complicating bacterial organisms associated with bluecomb | Indication |
Turkeys | Hexamitiasis caused by Hexamita meleagridis | Indication |
Turkeys | Iinfectious synovitis caused by Mycoplasma synoviae | Indication |
Turkeys | Air sacculitis (air-sac disease chronic respiratory disease) caused by Mycoplasma gallisepticum | Indication |
Turkeys | Cholera caused by Pasteurella multocida | Indication |
Turkeys | Infectious sinusitis caused by Mycoplasma gallisepticum | Indication |
Turkeys | Air sacculitis (air-sac disease chronic respiratory disease) caused by Escherichia coli | Indication |
Product | Applicant | Ingredients |
---|---|---|
Terramycin Vet Capsules | Zoetis Inc. | 1 |
TERRAMYCIN-343, TERRAMYCIN, TERRAMYCIN Soluble Powder Concentrate | Zoetis Inc. | 1 |
Terramycin Ophthalmic Ointment with Polymyxin | Zoetis Inc. | 2 |
Liquamycin Injectable, Terramycin Injectable | Zoetis Inc. | 1 |
TM-50 , TM-50 D , TM-100 , TM-100D | Phibro Animal Health Corp. | 1 |
Terramycin Scours Tablets | Zoetis Inc. | 1 |
Liquamycin Intramuscular | Zoetis Inc. | 2 |
Liqua-Cortril Spray, Terra-Cortril Spray | Zoetis Inc. | 2 |
MAGNA-TERRAMYCIN Soluble Powder | Zoetis Inc. | 2 |
OXY WS | Phibro Animal Health Corp. | 1 |
Terramycin 100 for Fish, Terramycin 200 for Fish | Phibro Animal Health Corp. | 1 |
Oxyject | Cronus Pharma Specialities India Private Limited | 1 |
MGA (liquid) and TM | Zoetis Inc. | 2 |
MGA and TM | Zoetis Inc. | 2 |
Bio-Mycin, Oxy-Tet 50 | Cronus Pharma Specialities India Private Limited | 1 |
Oxytetracycline-50 | Huvepharma EOOD | 1 |
Aquachel 100 mg | Zoetis Inc. | 2 |
Rachelle Oxyvet Injection | Zoetis Inc. | 1 |
Liquamycin 100, Terramycin 100 | Zoetis Inc. | 1 |
Neo-Terramycin 100/100, Neo-Terramycin 100/100D, Neo-Terramycin 50/50, Neo-Terramycin 50/50D | Phibro Animal Health Corp. | 2 |
Terramycin 10, Terramycin 30, Terramycin 50, Terramycin 100, Terramycin 200, Terramycin 200 Granular, Terramycin 100MR | Phibro Animal Health Corp. | 1 |
Bio-Mycin C, Oxy-Tet Injection | Boehringer lngelheim Animal Health USA Inc. | 1 |
Oxyject 100 | Cronus Pharma Specialities India Private Limited | 1 |
Coban/TM | Phibro Animal Health Corp. | 2 |
Aquachel-100, Oxyvet-100 | Zoetis Inc. | 1 |
TM plus Robenz | Phibro Animal Health Corp. | 2 |
Medamycin Injectable | Cronus Pharma Specialities India Private Limited | 1 |
Liquamycin LA-200, Liquamycin LA-200 (Rx) | Zoetis Inc. | 1 |
Compudose 200, Encore (Compudose 400 ) | Elanco US Inc. | 2 |
OXYMarine, Oxytet Soluble | Huvepharma EOOD | 1 |
Pennox 50, Pennox 100-MR, Pennox 100 Hi-Flo, Pennox 200 Hi-Flo | Pharmgate Inc. | 1 |
Neo-Oxy 100/100 MR, Neo-Oxy 50/50 | Pharmgate Inc. | 2 |
TM plus Bio-Cox | Phibro Animal Health Corp. | 2 |
BOVATEC and TM | Zoetis Inc. | 2 |
Oxytetracycline Hydrochloride Injection | Bimeda Animal Health Limited | 1 |
OXY 1000 Calf Bolus, OXY 500 Calf Bolus | Boehringer lngelheim Animal Health USA Inc. | 1 |
Noromycin 300 LA, TETRADURE 300 | Norbrook Laboratories, Ltd. | 1 |
Mecadox and Terramycin | Phibro Animal Health Corp. | 2 |
Hexasol Injection | Norbrook Laboratories, Ltd. | 2 |
Bio-Mycin 200 , Oxy-Tet 200 Injectable Solution | Boehringer lngelheim Animal Health USA Inc. | 1 |
Pennox 343 | Pharmgate Inc. | 1 |
AGRIMYCIN-343 | Huvepharma EOOD | 1 |
Oxytetracycline Hydrochloride Injection | Huvepharma EOOD | 1 |
Sacox / Terramycin | Huvepharma EOOD | 2 |
Oxytetracycline Injection, Oxytetracycline Injection | Bimeda Animal Health Limited | 1 |
Maxim-200 Injection, Oxytetracycline Hydrochloride Injection 200mg | Huvepharma EOOD | 1 |
Agrimycin - 200 | Huvepharma EOOD | 1 |
Tetroxy HCA-280, Tetroxy HCA-1772, Tetroxy HCA-1400 | Bimeda Animal Health Limited | 1 |
Tetroxy 25 | Bimeda Animal Health Limited | 1 |
Oxytetracycline 200, Pennox 200 | Pharmgate Inc. | 1 |
Tetroxy 343 | Bimeda Animal Health Limited | 1 |
Oxytetracycline Injection 200 | Norbrook Laboratories, Ltd. | 1 |
Oxytet 100 | Norbrook Laboratories, Ltd. | 1 |
Tetroxy Aquatic | Bimeda Animal Health Limited | 1 |
Tetroxy-LA | Bimeda Animal Health Limited | 1 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 3.29 | acidic |
pKa2 | 7.19 | acidic |
pKa3 | 9.79 | acidic |
pKa4 | 11.29 | acidic |
pKa5 | 12.0 | acidic |
pKa6 | 12.56 | acidic |
pKa7 | 13.24 | acidic |
pKa8 | 9.06 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
30S ribosomal protein S4 | Ribosomal protein | WOMBAT-PK | |||||||
30S ribosomal protein S9 | Ribosomal protein | WOMBAT-PK |
ID | Source |
---|---|
4018624 | VUID |
N0000146937 | NUI |
D00205 | KEGG_DRUG |
4018623 | VANDF |
4018624 | VANDF |
4018625 | VANDF |
C0030092 | UMLSCUI |
CHEBI:133011 | CHEBI |
OTC | PDB_CHEM_ID |
CHEMBL1517 | ChEMBL_ID |
D010118 | MESH_DESCRIPTOR_UI |
DB00595 | DRUGBANK_ID |
10919 | IUPHAR_LIGAND_ID |
13303-91-8 | SECONDARY_CAS_RN |
2058-46-0 | SECONDARY_CAS_RN |
X20I9EN955 | UNII |
54675779 | PUBCHEM_CID |
1545999 | RXNORM |
2370 | MMSL |
33508 | MMSL |
5221 | MMSL |
5222 | MMSL |
d01070 | MMSL |
002742 | NDDF |
002743 | NDDF |
002744 | NDDF |
1269152006 | SNOMEDCT_US |
22969001 | SNOMEDCT_US |
372675006 | SNOMEDCT_US |
395819008 | SNOMEDCT_US |
442345001 | SNOMEDCT_US |
54729007 | SNOMEDCT_US |
CHEMBL3989568 | ChEMBL_ID |
CHEMBL1607480 | ChEMBL_ID |
103 | INN_ID |
6153-64-6 | SECONDARY_CAS_RN |
None