oxcarbazepine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
tricyclic compounds 2017 28721-07-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • oxcarbazepine
  • oxacarbazepine
  • oxecarb
  • oxetol
an antiepileptic drug, precise mechanism by which oxcarbazepine exerts its antiseizure effect is unknown, however, in vitro electrophysiological studies indicate that it produces blockade of voltage-sensitive sodium channels, resulting in stabilization of hyperexcited neural membranes, inhibition of repetitive neuronal firing, and diminution of propagation of synaptic impulses
  • Molecular weight: 252.27
  • Formula: C15H12N2O2
  • CLOGP: 1.21
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 63.40
  • ALOGS: -3.20
  • ROTB: 0

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.09 mg/mL Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 135.90 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 95 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Jan. 14, 2000 FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 1109.36 13.01 714 25566 117160 50461684
Hyponatraemia 548.58 13.01 430 25850 95709 50483135
Abortion spontaneous 253.29 13.01 194 26086 41578 50537266
Generalised tonic-clonic seizure 183.60 13.01 133 26147 26177 50552667
Status epilepticus 165.64 13.01 97 26183 13309 50565535
Epilepsy 164.24 13.01 115 26165 21452 50557392
Focal dyscognitive seizures 162.42 13.01 59 26221 2673 50576171
Diplopia 156.78 13.01 107 26173 19153 50559691
Completed suicide 141.51 13.01 249 26031 131640 50447204
Petit mal epilepsy 134.26 13.01 54 26226 3235 50575609
Product substitution issue 121.34 13.01 81 26199 13976 50564868
Aggression 119.06 13.01 94 26186 21022 50557822
Psychogenic seizure 116.19 13.01 40 26240 1545 50577299
Somnolence 108.73 13.01 245 26035 154740 50424104
Drug interaction 100.48 13.01 278 26002 199343 50379501
Exposure during pregnancy 98.25 13.01 203 26077 120812 50458032
Inappropriate antidiuretic hormone secretion 97.53 13.01 69 26211 13074 50565770
Blood sodium decreased 95.96 13.01 83 26197 21064 50557780
Psychotic disorder 85.85 13.01 79 26201 21733 50557111
Multiple-drug resistance 78.26 13.01 37 26243 3277 50575567
Abnormal behaviour 75.05 13.01 70 26210 19588 50559256
Mitochondrial DNA mutation 70.91 13.01 18 26262 232 50578612
Irritability 68.35 13.01 79 26201 28347 50550497
Propofol infusion syndrome 66.69 13.01 22 26258 744 50578100
Suicide attempt 65.11 13.01 105 26175 51627 50527217
Partial seizures 64.86 13.01 37 26243 4828 50574016
Mania 64.56 13.01 50 26230 10866 50567978
Joint swelling 63.53 13.01 24 26256 245262 50333582
Ataxia 62.31 13.01 54 26226 13732 50565112
Hyperammonaemic encephalopathy 62.03 13.01 27 26253 1972 50576872
Myoclonic epilepsy 61.49 13.01 22 26258 953 50577891
Balance disorder 59.09 13.01 120 26160 70470 50508374
Infantile spasms 58.83 13.01 15 26265 197 50578647
Dizziness 58.13 13.01 342 25938 346027 50232817
Suicidal ideation 57.26 13.01 103 26177 55282 50523562
Infusion related reaction 56.42 13.01 10 26270 169547 50409297
Maternal exposure during pregnancy 53.98 13.01 194 26086 159584 50419260
Contraindicated product administered 53.63 13.01 7 26273 148951 50429893
Hypochloraemia 53.58 13.01 23 26257 1624 50577220
Speech disorder 52.93 13.01 78 26202 35470 50543374
Arthralgia 52.75 13.01 92 26188 438610 50140234
Nystagmus 52.74 13.01 34 26246 5527 50573317
Drug reaction with eosinophilia and systemic symptoms 49.16 13.01 67 26213 28357 50550487
Bipolar disorder 49.03 13.01 35 26245 6722 50572122
Glossodynia 48.09 13.01 3 26277 115566 50463278
Nasopharyngitis 48.09 13.01 20 26260 192907 50385937
Peripheral swelling 47.22 13.01 24 26256 205912 50372932
Tremor 47.17 13.01 149 26131 114754 50464090
Intentional overdose 46.20 13.01 101 26179 62403 50516441
Gene mutation 45.50 13.01 19 26261 1252 50577592
Toxicity to various agents 45.18 13.01 224 26056 212275 50366569
Diarrhoea 45.13 13.01 156 26124 588320 49990524
Sudden unexplained death in epilepsy 44.98 13.01 13 26267 280 50578564
Sedation 43.90 13.01 66 26214 30544 50548300
Anticonvulsant drug level decreased 43.59 13.01 18 26262 1153 50577691
Arthropathy 43.34 13.01 14 26266 157892 50420952
Drug level decreased 43.22 13.01 32 26248 6501 50572343
Agitation 42.60 13.01 89 26191 53295 50525549
Blood gases abnormal 42.50 13.01 15 26265 624 50578220
Infection 41.40 13.01 19 26261 172935 50405909
Memory impairment 40.28 13.01 111 26169 79249 50499595
Systemic lupus erythematosus 39.43 13.01 12 26268 140610 50438234
Pain 38.84 13.01 162 26118 578741 50000103
Swelling 38.30 13.01 29 26251 200843 50378001
Gastric lavage 37.87 13.01 8 26272 42 50578802
Alopecia 37.74 13.01 43 26237 245004 50333840
Tonic convulsion 37.36 13.01 16 26264 1123 50577721
Depression 37.02 13.01 177 26103 165246 50413598
Simple partial seizures 36.99 13.01 13 26267 534 50578310
Paradoxical drug reaction 36.33 13.01 23 26257 3624 50575220
Rheumatoid arthritis 35.21 13.01 32 26248 202518 50376326
Respiratory arrest 35.17 13.01 59 26221 29950 50548894
Pneumonia 34.90 13.01 92 26188 378309 50200535
Cross sensitivity reaction 34.65 13.01 18 26262 1951 50576893
Pregnancy 34.46 13.01 58 26222 29519 50549325
Cough 34.34 13.01 45 26235 241219 50337625
Febrile neutropenia 31.95 13.01 6 26274 97661 50481183
Dyskinesia 31.62 13.01 54 26226 27807 50551037
Hypothermia 31.61 13.01 35 26245 11981 50566863
Abortion induced 31.36 13.01 31 26249 9313 50569531
Partial seizures with secondary generalisation 30.96 13.01 10 26270 316 50578528
Sinusitis 30.78 13.01 26 26254 170532 50408312
Aphasia 30.73 13.01 54 26226 28440 50550404
Dyspnoea 30.39 13.01 164 26116 547444 50031400
Electroencephalogram abnormal 29.79 13.01 20 26260 3479 50575365
Unmasking of previously unidentified disease 29.10 13.01 12 26268 766 50578078
Cognitive disorder 28.92 13.01 68 26212 44055 50534789
Stevens-Johnson syndrome 28.52 13.01 45 26235 21707 50557137
Blood osmolarity decreased 28.19 13.01 12 26268 830 50578014
Trigeminal neuralgia 26.99 13.01 18 26262 3097 50575747
Neuroleptic malignant syndrome 26.86 13.01 31 26249 11099 50567745
Brown tumour 26.80 13.01 6 26274 43 50578801
Mental disorder 26.79 13.01 44 26236 21947 50556897
Electrocardiogram QRS complex prolonged 26.33 13.01 22 26258 5322 50573522
Anaemia 25.90 13.01 58 26222 252398 50326446
Neurotoxicity 25.87 13.01 35 26245 14705 50564139
Overdose 25.48 13.01 111 26169 99616 50479228
Dysmorphism 24.98 13.01 15 26265 2152 50576692
Multiple sclerosis 24.96 13.01 41 26239 20452 50558392
Atonic seizures 24.81 13.01 10 26270 602 50578242
Low set ears 24.49 13.01 8 26272 262 50578582
Coma blister 24.34 13.01 7 26273 148 50578696
Change in seizure presentation 24.32 13.01 8 26272 268 50578576
Lennox-Gastaut syndrome 24.29 13.01 8 26272 269 50578575
Bipolar I disorder 24.23 13.01 13 26267 1505 50577339
Catatonia 24.04 13.01 18 26262 3718 50575126
Drug ineffective for unapproved indication 23.82 13.01 41 26239 21240 50557604
Parkinsonism 23.67 13.01 26 26254 8821 50570023
Aura 23.34 13.01 11 26269 967 50577877
Atrial fibrillation 23.08 13.01 12 26268 101733 50477111
Therapeutic product effective for unapproved indication 22.92 13.01 6 26274 88 50578756
Discomfort 22.84 13.01 14 26266 108366 50470478
Drug withdrawal convulsions 22.76 13.01 12 26268 1341 50577503
Drug level increased 22.73 13.01 38 26242 19230 50559614
Psychomotor hyperactivity 22.60 13.01 26 26254 9275 50569569
Poisoning 22.56 13.01 30 26250 12399 50566445
Tardive dyskinesia 22.32 13.01 23 26257 7256 50571588
Dysphoria 22.18 13.01 19 26261 4755 50574089
Therapeutic product ineffective for unapproved indication 22.18 13.01 7 26273 205 50578639
Renal impairment 22.04 13.01 6 26274 75655 50503189
Muscle twitching 21.73 13.01 33 26247 15398 50563446
Blood lactic acid increased 21.52 13.01 20 26260 5565 50573279
Stomatitis 21.48 13.01 13 26267 101331 50477513
Loss of consciousness 21.42 13.01 109 26171 104244 50474600
Impaired healing 21.36 13.01 5 26275 69781 50509063
Treatment failure 21.33 13.01 24 26256 137613 50441231
Electrocardiogram repolarisation abnormality 21.20 13.01 11 26269 1189 50577655
Ventricular hypokinesia 20.89 13.01 17 26263 3963 50574881
Chronic papillomatous dermatitis 20.59 13.01 5 26275 53 50578791
Sopor 20.57 13.01 37 26243 19842 50559002
Hallucination 20.51 13.01 62 26218 46595 50532249
Normal newborn 20.26 13.01 21 26259 6670 50572174
Drug withdrawal syndrome 20.22 13.01 42 26238 25039 50553805
Intentional self-injury 20.17 13.01 40 26240 23072 50555772
Gaze palsy 20.12 13.01 11 26269 1322 50577522
Crying 19.86 13.01 37 26243 20379 50558465
General physical health deterioration 19.80 13.01 27 26253 142407 50436437
Atrioventricular block first degree 19.75 13.01 20 26260 6181 50572663
Follicular mucinosis 19.69 13.01 3 26277 0 50578844
Congenital epiglottal anomaly 19.69 13.01 3 26277 0 50578844
Strabismus 19.38 13.01 12 26268 1818 50577026
Brain operation 19.34 13.01 8 26272 515 50578329
Abdominal discomfort 19.33 13.01 59 26221 231582 50347262
Coma 19.11 13.01 69 26211 56810 50522034
Phobia 19.10 13.01 7 26273 325 50578519
Systolic dysfunction 19.10 13.01 11 26269 1461 50577383
Visual impairment 18.99 13.01 78 26202 68197 50510647
Mood altered 18.97 13.01 28 26252 12745 50566099
Caesarean section 18.66 13.01 31 26249 15608 50563236
Electrocardiogram ST segment elevation 18.58 13.01 15 26265 3458 50575386
Hypotonia 18.54 13.01 22 26258 8112 50570732
Screaming 18.39 13.01 14 26266 2964 50575880
Acute kidney injury 18.39 13.01 59 26221 227999 50350845
Drug intolerance 18.15 13.01 56 26224 219048 50359796
Neonatal seizure 18.14 13.01 7 26273 375 50578469
Drug resistance 17.96 13.01 34 26246 18955 50559889
Head injury 17.94 13.01 39 26241 23981 50554863
Ammonia increased 17.94 13.01 16 26264 4225 50574619
Seizure cluster 17.83 13.01 6 26274 216 50578628
Hypersensitivity 17.81 13.01 55 26225 215106 50363738
Therapeutic product effect decreased 17.72 13.01 27 26253 136023 50442821
Poisoning deliberate 17.37 13.01 21 26259 7891 50570953
Paranoia 17.30 13.01 24 26256 10324 50568520
Anger 17.05 13.01 25 26255 11308 50567536
Epistaxis 16.96 13.01 6 26274 63948 50514896
Therapeutic response unexpected 16.95 13.01 30 26250 15885 50562959
Stillbirth 16.81 13.01 18 26262 5934 50572910
Logorrhoea 16.77 13.01 12 26268 2312 50576532
Death 16.61 13.01 100 26180 325279 50253565
Immunodeficiency common variable 16.59 13.01 5 26275 125 50578719
Disturbance in attention 16.19 13.01 44 26236 31142 50547702
Anticonvulsant drug level above therapeutic 16.15 13.01 7 26273 506 50578338
Thyroxine free decreased 15.95 13.01 7 26273 521 50578323
Sleep paralysis 15.90 13.01 7 26273 525 50578319
Arthritis 15.90 13.01 13 26267 86708 50492136
Restlessness 15.63 13.01 38 26242 25135 50553709
Malignant neoplasm progression 15.50 13.01 8 26272 68116 50510728
Pain in extremity 15.47 13.01 81 26199 272784 50306060
Delusion 15.45 13.01 23 26257 10546 50568298
Automatism 15.39 13.01 4 26276 57 50578787
Coordination abnormal 15.31 13.01 24 26256 11510 50567334
Pleural effusion 15.20 13.01 12 26268 81442 50497402
Hallucination, auditory 15.19 13.01 23 26257 10705 50568139
Dyspnoea exertional 15.04 13.01 4 26276 51229 50527615
Sepsis 14.91 13.01 29 26251 132896 50445948
Learning disorder 14.90 13.01 7 26273 611 50578233
Cardiac arrest 14.86 13.01 84 26196 83567 50495277
Cardiopulmonary failure 14.81 13.01 13 26267 3360 50575484
Educational problem 14.70 13.01 6 26274 373 50578471
Condition aggravated 14.66 13.01 226 26054 296832 50282012
Cardio-respiratory arrest 14.54 13.01 61 26219 53831 50525013
Fatigue 14.43 13.01 270 26010 707331 49871513
Social fear 14.32 13.01 3 26277 15 50578829
Behaviour disorder 14.28 13.01 11 26269 2369 50576475
Product complaint 14.04 13.01 23 26257 11443 50567401
Fall 14.02 13.01 248 26032 334684 50244160
Productive cough 13.88 13.01 5 26275 52689 50526155
Herpes zoster 13.76 13.01 10 26270 70776 50508068
Immune thrombocytopenia 13.72 13.01 20 26260 8997 50569847
Hyperkalaemia 13.66 13.01 4 26276 48085 50530759
Fever neonatal 13.59 13.01 3 26277 20 50578824
Gun shot wound 13.55 13.01 4 26276 93 50578751
Granulocytopenia 13.35 13.01 15 26265 5216 50573628
Irritable bowel syndrome 13.34 13.01 5 26275 51436 50527408
Extensor plantar response 13.33 13.01 8 26272 1146 50577698
Nasal congestion 13.21 13.01 5 26275 51115 50527729
Amenorrhoea 13.18 13.01 19 26261 8465 50570379

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 1000.81 14.24 654 17687 92469 29463717
Hyponatraemia 324.14 14.24 295 18046 67338 29488848
Product substitution issue 186.89 14.24 98 18243 9074 29547112
Aggression 181.72 14.24 161 18180 35380 29520806
Generalised tonic-clonic seizure 158.32 14.24 115 18226 19024 29537162
Epilepsy 135.10 14.24 103 18238 18329 29537857
Status epilepticus 125.31 14.24 80 18261 10714 29545472
Somnolence 106.72 14.24 201 18140 93754 29462432
Partial seizures 103.89 14.24 50 18291 3853 29552333
Sudden unexplained death in epilepsy 100.97 14.24 28 18313 428 29555758
Drug ineffective 99.66 14.24 466 17875 362704 29193482
Multiple-drug resistance 97.90 14.24 48 18293 3852 29552334
Stevens-Johnson syndrome 92.84 14.24 79 18262 16418 29539768
Petit mal epilepsy 88.34 14.24 40 18301 2682 29553504
Nystagmus 70.95 14.24 40 18301 4269 29551917
Ataxia 70.23 14.24 59 18282 12044 29544142
Death 68.50 14.24 67 18274 342017 29214169
Abnormal behaviour 66.85 14.24 77 18264 23050 29533136
Inappropriate antidiuretic hormone secretion 64.89 14.24 54 18287 10878 29545308
Drug interaction 63.43 14.24 266 18075 197119 29359067
Intellectual disability 57.87 14.24 23 18318 1114 29555072
Acute kidney injury 57.76 14.24 48 18293 265219 29290967
Electroencephalogram abnormal 56.40 14.24 28 18313 2307 29553879
Pneumonia 53.96 14.24 72 18269 320100 29236086
Behaviour disorder 50.07 14.24 30 18311 3586 29552600
Irritability 49.84 14.24 65 18276 22087 29534099
Febrile neutropenia 49.01 14.24 6 18335 112234 29443952
Dyspnoea 46.85 14.24 82 18259 326650 29229536
Focal dyscognitive seizures 45.85 14.24 20 18321 1226 29554960
Anaemia 44.13 14.24 36 18305 200915 29355271
Memory impairment 43.77 14.24 80 18261 36390 29519796
Cognitive disorder 42.41 14.24 62 18279 23437 29532749
Agitation 40.85 14.24 95 18246 51209 29504977
Myoclonic epilepsy 40.33 14.24 17 18324 958 29555228
Blood sodium decreased 39.07 14.24 47 18294 14720 29541466
Educational problem 38.94 14.24 14 18327 513 29555673
Coma 38.15 14.24 79 18262 39371 29516815
Diarrhoea 37.21 14.24 96 18245 332602 29223584
Colitis ischaemic 37.15 14.24 30 18311 5793 29550393
Hyperammonaemic encephalopathy 36.95 14.24 20 18321 1970 29554216
Psychomotor hyperactivity 35.66 14.24 34 18307 8179 29548007
Intentional self-injury 35.18 14.24 41 18300 12420 29543766
Hypochloraemia 34.84 14.24 13 18328 530 29555656
Psychotic disorder 34.28 14.24 52 18289 20302 29535884
Drug level decreased 33.27 14.24 29 18312 6218 29549968
Autism spectrum disorder 31.13 14.24 18 18323 2014 29554172
Autonomic nervous system imbalance 31.06 14.24 19 18322 2357 29553829
Simple partial seizures 30.99 14.24 10 18331 262 29555924
Speech disorder developmental 29.50 14.24 17 18324 1890 29554296
Aura 29.28 14.24 10 18331 314 29555872
Cardiac failure congestive 29.13 14.24 6 18335 76575 29479611
Depressed mood 29.10 14.24 43 18298 16405 29539781
Sepsis 28.37 14.24 28 18313 142654 29413532
Disturbance in attention 28.27 14.24 49 18292 21375 29534811
Diplopia 27.84 14.24 38 18303 13480 29542706
Completed suicide 27.61 14.24 120 18221 90126 29466060
Depression 27.42 14.24 115 18226 85032 29471154
Suicidal ideation 27.30 14.24 64 18277 34652 29521534
Anticonvulsant drug level decreased 26.95 14.24 13 18328 1006 29555180
Affective disorder 26.31 14.24 19 18322 3107 29553079
Hallucination, auditory 26.14 14.24 31 18310 9562 29546624
Developmental coordination disorder 26.07 14.24 8 18333 177 29556009
Dissociation 25.68 14.24 13 18328 1116 29555070
Hypothermia 25.41 14.24 30 18311 9209 29546977
Drug withdrawal convulsions 25.34 14.24 13 18328 1148 29555038
Anxiety 24.96 14.24 112 18229 85253 29470933
Tic 24.83 14.24 15 18326 1820 29554366
Otitis media 24.73 14.24 17 18324 2572 29553614
Brain malformation 24.66 14.24 7 18334 117 29556069
Platelet count decreased 23.89 14.24 18 18323 104654 29451532
Irregular sleep phase 23.88 14.24 6 18335 61 29556125
Thyroxine free decreased 23.52 14.24 8 18333 248 29555938
Enuresis 23.07 14.24 15 18326 2069 29554117
Sopor 22.91 14.24 31 18310 10903 29545283
Coordination abnormal 22.79 14.24 25 18316 7089 29549097
Condition aggravated 22.79 14.24 162 18179 146133 29410053
Dysmorphism 22.62 14.24 17 18324 2954 29553232
Gait disturbance 22.02 14.24 97 18244 73252 29482934
Hyperammonaemia 21.89 14.24 22 18319 5641 29550545
Wrong patient received product 21.83 14.24 15 18326 2267 29553919
Impulsive behaviour 21.55 14.24 14 18327 1929 29554257
Balance disorder 21.50 14.24 60 18281 36110 29520076
Speech disorder 21.45 14.24 46 18295 23470 29532716
Trigeminal neuralgia 21.03 14.24 11 18330 1011 29555175
Psychogenic seizure 20.90 14.24 8 18333 350 29555836
Pancytopenia 20.70 14.24 13 18328 83155 29473031
Nervousness 20.64 14.24 30 18311 11276 29544910
Renal failure 20.58 14.24 26 18315 118573 29437613
Idiopathic generalised epilepsy 20.55 14.24 5 18336 44 29556142
Gastrointestinal haemorrhage 20.40 14.24 12 18329 79521 29476665
Bradykinesia 20.39 14.24 17 18324 3430 29552756
Seizure cluster 20.22 14.24 6 18335 118 29556068
Neuroleptic malignant syndrome 20.10 14.24 36 18305 16112 29540074
Arthralgia 19.96 14.24 35 18306 139582 29416604
Overweight 19.94 14.24 12 18329 1446 29554740
Dizziness 19.85 14.24 192 18149 189492 29366694
Oedema peripheral 19.80 14.24 21 18320 103536 29452650
Psychomotor skills impaired 19.76 14.24 15 18326 2646 29553540
Motor developmental delay 19.23 14.24 9 18332 651 29555535
Granulocytopenia 19.09 14.24 21 18320 5973 29550213
Back pain 18.18 14.24 22 18319 102262 29453924
Hypotension 18.09 14.24 61 18280 194293 29361893
Colitis microscopic 17.85 14.24 12 18329 1751 29554435
Malignant neoplasm progression 17.76 14.24 12 18329 73847 29482339
Congenital scoliosis 17.76 14.24 5 18336 81 29556105
Large granular lymphocytosis 17.46 14.24 6 18335 192 29555994
Craniocerebral injury 17.37 14.24 14 18327 2694 29553492
Anticonvulsant drug level increased 17.34 14.24 11 18330 1455 29554731
Parasomnia 17.18 14.24 7 18334 362 29555824
Suicide attempt 16.86 14.24 53 18288 34057 29522129
Terminal insomnia 16.43 14.24 7 18334 405 29555781
Cardiac failure 16.39 14.24 15 18326 79272 29476914
Hand fracture 16.35 14.24 11 18330 1606 29554580
Congenital knee deformity 16.24 14.24 5 18336 112 29556074
Drug withdrawal syndrome 16.20 14.24 35 18306 17949 29538237
Sleep deficit 15.93 14.24 7 18334 437 29555749
Therapeutic response unexpected 15.88 14.24 23 18318 8615 29547571
Interstitial lung disease 15.83 14.24 8 18333 57710 29498476
Anger 15.81 14.24 26 18315 10864 29545322
Dyskinesia 15.78 14.24 37 18304 20024 29536162
Haemoglobin decreased 15.63 14.24 27 18314 108348 29447838
Staring 15.45 14.24 10 18331 1369 29554817
Head banging 15.43 14.24 5 18336 133 29556053
General physical health deterioration 15.41 14.24 25 18316 102832 29453354
Croup infectious 15.31 14.24 6 18335 280 29555906
Congenital eyelid malformation 15.02 14.24 4 18337 52 29556134
Lid lag 15.01 14.24 3 18338 9 29556177
Bipolar disorder 14.99 14.24 14 18327 3281 29552905
Encephalitis autoimmune 14.82 14.24 7 18334 517 29555669
Confusional state 14.64 14.24 132 18209 127745 29428441
Erythrosis 14.62 14.24 4 18337 58 29556128
Mania 14.40 14.24 22 18319 8641 29547545
Tardive dyskinesia 14.34 14.24 17 18324 5241 29550945

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 1294.67 12.40 908 33700 165984 64298140
Hyponatraemia 707.77 12.40 606 34002 147733 64316391
Generalised tonic-clonic seizure 264.49 12.40 198 34410 39659 64424465
Aggression 240.60 12.40 199 34409 46033 64418091
Status epilepticus 230.29 12.40 144 34464 21519 64442605
Epilepsy 197.06 12.40 155 34453 33376 64430748
Completed suicide 193.37 12.40 393 34215 224021 64240103
Somnolence 189.09 12.40 368 34240 203277 64260847
Focal dyscognitive seizures 171.22 12.40 65 34543 3225 64460899
Petit mal epilepsy 163.90 12.40 71 34537 4961 64459163
Drug interaction 156.99 12.40 488 34120 361595 64102529
Multiple-drug resistance 146.49 12.40 71 34537 6431 64457693
Inappropriate antidiuretic hormone secretion 146.18 12.40 110 34498 22179 64441945
Product substitution issue 144.21 12.40 100 34508 17761 64446363
Partial seizures 135.74 12.40 70 34538 7237 64456887
Psychogenic seizure 135.55 12.40 47 34561 1794 64462330
Diplopia 128.45 12.40 110 34498 26655 64437469
Nystagmus 121.57 12.40 70 34538 8998 64455126
Sudden unexplained death in epilepsy 118.79 12.40 33 34575 592 64463532
Stevens-Johnson syndrome 112.57 12.40 114 34494 34135 64429989
Psychotic disorder 106.24 12.40 111 34497 34467 64429657
Ataxia 104.41 12.40 90 34518 21994 64442130
Hyperammonaemic encephalopathy 102.68 12.40 48 34560 4010 64460114
Abnormal behaviour 96.33 12.40 104 34504 33518 64430606
Myoclonic epilepsy 84.50 12.40 32 34576 1576 64462548
Irritability 80.56 12.40 99 34509 36647 64427477
Hypochloraemia 80.19 12.40 33 34575 2028 64462096
Blood sodium decreased 77.20 12.40 87 34521 29395 64434729
Suicidal ideation 75.13 12.40 131 34477 66411 64397713
Agitation 72.65 12.40 152 34456 88215 64375909
Suicide attempt 71.50 12.40 133 34475 70874 64393250
Mitochondrial DNA mutation 69.69 12.40 18 34590 241 64463883
Drug level decreased 69.33 12.40 54 34554 11449 64452675
Electroencephalogram abnormal 69.30 12.40 40 34568 5163 64458961
Balance disorder 68.57 12.40 144 34464 83782 64380342
Infantile spasms 68.11 12.40 18 34590 265 64463859
Febrile neutropenia 67.72 12.40 10 34598 187647 64276477
Drug ineffective 66.13 12.40 714 33894 839533 63624591
Pneumonia 65.28 12.40 126 34482 559450 63904674
Memory impairment 64.25 12.40 142 34466 85540 64378584
Dyspnoea 60.98 12.40 191 34417 718483 63745641
Dizziness 58.01 12.40 412 34196 429751 64034373
Drug reaction with eosinophilia and systemic symptoms 57.66 12.40 104 34504 54113 64410011
Hypothermia 56.13 12.40 61 34547 19795 64444329
Anaemia 54.69 12.40 74 34534 378606 64085518
Anticonvulsant drug level decreased 53.70 12.40 24 34584 1806 64462318
Acute kidney injury 53.36 12.40 100 34508 449140 64014984
Propofol infusion syndrome 53.26 12.40 23 34585 1594 64462530
Mania 53.12 12.40 54 34554 16232 64447892
Arthralgia 52.92 12.40 98 34510 442162 64021962
Neuroleptic malignant syndrome 52.62 12.40 66 34542 24930 64439194
Diarrhoea 51.95 12.40 206 34402 722498 63741626
Behaviour disorder 50.80 12.40 31 34577 4431 64459693
Infusion related reaction 50.43 12.40 13 34595 164454 64299670
Bipolar disorder 50.26 12.40 36 34572 6725 64457399
Cognitive disorder 47.89 12.40 97 34511 54990 64409134
Speech disorder 47.83 12.40 90 34518 48351 64415773
Joint swelling 46.58 12.40 29 34579 215353 64248771
Death 45.43 12.40 122 34486 482583 63981541
Coma 45.32 12.40 126 34482 87489 64376635
Dyskinesia 45.03 12.40 78 34530 39310 64424814
Intentional self-injury 44.89 12.40 66 34542 28978 64435146
Intentional overdose 44.23 12.40 127 34481 89817 64374307
Intellectual disability 42.13 12.40 17 34591 993 64463131
Simple partial seizures 41.31 12.40 15 34593 656 64463468
Sopor 41.01 12.40 64 34544 29597 64434527
Cross sensitivity reaction 39.89 12.40 24 34584 3343 64460781
Blood gases abnormal 39.13 12.40 16 34592 967 64463157
Sedation 38.43 12.40 75 34533 41387 64422737
Drug withdrawal convulsions 38.41 12.40 20 34588 2108 64462016
Depression 36.96 12.40 195 34413 183096 64281028
Granulocytopenia 36.59 12.40 36 34572 10404 64453720
Mental disorder 36.48 12.40 57 34551 26388 64437736
Contraindicated product administered 36.11 12.40 7 34601 107822 64356302
Gene mutation 35.96 12.40 19 34589 2063 64462061
Peripheral swelling 35.38 12.40 36 34572 209117 64255007
Gastric lavage 35.28 12.40 8 34600 59 64464065
Psychomotor hyperactivity 35.05 12.40 41 34567 14410 64449714
Thyroxine free decreased 34.51 12.40 14 34594 829 64463295
Cough 34.31 12.40 69 34539 302079 64162045
Sepsis 34.24 12.40 44 34564 230297 64233827
Lower respiratory tract infection 34.21 12.40 5 34603 94609 64369515
Seizure cluster 33.54 12.40 11 34597 353 64463771
Drug withdrawal syndrome 33.23 12.40 60 34548 31231 64432893
Toxicity to various agents 32.71 12.40 318 34290 363195 64100929
Dissociation 31.94 12.40 20 34588 2991 64461133
Catatonia 31.91 12.40 29 34579 7591 64456533
Anticonvulsant drug level above therapeutic 31.80 12.40 14 34594 1016 64463108
Rheumatoid arthritis 31.71 12.40 25 34583 164269 64299855
General physical health deterioration 31.48 12.40 38 34570 204387 64259737
Swelling 31.40 12.40 24 34584 160194 64303930
Trigeminal neuralgia 31.35 12.40 20 34588 3089 64461035
Paradoxical drug reaction 31.09 12.40 26 34582 6094 64458030
Brain malformation 30.82 12.40 7 34601 52 64464072
Disturbance in attention 30.69 12.40 68 34540 41006 64423118
Anger 30.67 12.40 40 34568 15701 64448423
Partial seizures with secondary generalisation 30.29 12.40 11 34597 481 64463643
Lennox-Gastaut syndrome 30.04 12.40 9 34599 213 64463911
Hallucination, auditory 29.87 12.40 41 34567 16898 64447226
Cardiac failure 29.76 12.40 17 34591 132356 64331768
Aphasia 29.75 12.40 67 34541 40839 64423285
Arthropathy 29.47 12.40 14 34594 120953 64343171
Educational problem 28.53 12.40 10 34598 394 64463730
Oedema peripheral 28.43 12.40 43 34565 210274 64253850
Respiratory arrest 28.18 12.40 77 34531 52908 64411216
Tremor 28.04 12.40 155 34453 148075 64316049
Wrong patient received product 27.89 12.40 20 34588 3742 64460382
Gait disturbance 27.39 12.40 172 34436 171983 64292141
Tardive dyskinesia 27.35 12.40 29 34579 9149 64454975
Drug resistance 27.23 12.40 59 34549 35043 64429081
Atrial fibrillation 27.20 12.40 31 34577 171058 64293066
Pain 27.06 12.40 180 34428 553331 63910793
Impulsive behaviour 26.53 12.40 17 34591 2646 64461478
Blood osmolarity decreased 26.53 12.40 13 34595 1205 64462919
Encephalitis autoimmune 26.47 12.40 15 34593 1869 64462255
Brown tumour 26.25 12.40 6 34602 46 64464078
Malignant neoplasm progression 26.09 12.40 14 34594 112857 64351267
Poisoning 25.89 12.40 44 34564 21835 64442289
Dysmorphism 25.70 12.40 10 34598 530 64463594
Parkinsonism 25.66 12.40 35 34573 14338 64449786
Bradykinesia 25.60 12.40 24 34584 6536 64457588
Therapeutic product ineffective for unapproved indication 25.44 12.40 7 34601 121 64464003
Psychomotor skills impaired 25.25 12.40 19 34589 3826 64460298
Back pain 25.20 12.40 61 34547 250110 64214014
Drug level increased 24.85 12.40 56 34552 34140 64429984
Strabismus 24.72 12.40 15 34593 2122 64462002
Bipolar I disorder 24.61 12.40 14 34594 1757 64462367
Glossodynia 24.38 12.40 3 34605 64693 64399431
Aura 24.35 12.40 11 34597 849 64463275
Autonomic nervous system imbalance 24.04 12.40 19 34589 4113 64460011
Irregular sleep phase 23.91 12.40 6 34602 71 64464053
Infection 23.84 12.40 39 34569 184841 64279283
Tonic convulsion 23.83 12.40 14 34594 1867 64462257
Nasopharyngitis 23.79 12.40 43 34565 196030 64268094
Drug ineffective for unapproved indication 23.77 12.40 52 34556 31081 64433043
Multiple sclerosis 23.62 12.40 39 34569 18902 64445222
Blood creatine phosphokinase increased 23.47 12.40 77 34531 58481 64405643
Pericarditis 23.32 12.40 3 34605 62513 64401611
Change in seizure presentation 23.23 12.40 8 34600 299 64463825
Terminal insomnia 23.15 12.40 11 34597 953 64463171
Staring 23.06 12.40 15 34593 2395 64461729
Parasomnia 22.97 12.40 9 34599 486 64463638
Abortion spontaneous 22.71 12.40 45 34563 25098 64439026
Cardiac failure congestive 22.61 12.40 22 34586 130558 64333566
Anticonvulsant drug level below therapeutic 22.52 12.40 11 34597 1013 64463111
Malaise 22.41 12.40 123 34485 396124 64068000
Gaze palsy 22.29 12.40 15 34593 2535 64461589
Paranoia 22.21 12.40 35 34573 16317 64447807
Hyperammonaemia 22.21 12.40 27 34581 9877 64454247
Learning disorder 22.12 12.40 9 34599 537 64463587
Overdose 22.09 12.40 154 34454 159412 64304712
Electrocardiogram QRS complex prolonged 22.04 12.40 26 34582 9218 64454906
Speech disorder developmental 21.91 12.40 9 34599 550 64463574
Affective disorder 21.79 12.40 22 34586 6558 64457566
Craniocerebral injury 21.75 12.40 18 34590 4158 64459966
Therapeutic product effective for unapproved indication 21.68 12.40 6 34602 106 64464018
Colitis ischaemic 21.47 12.40 31 34577 13383 64450741
Coma blister 21.21 12.40 7 34601 229 64463895
Neurotoxicity 21.18 12.40 46 34562 27358 64436766
Herpes zoster 21.15 12.40 8 34600 79179 64384945
Hypotonia 21.08 12.40 28 34580 11184 64452940
Dysarthria 21.08 12.40 75 34533 59331 64404793
Stomatitis 20.74 12.40 17 34591 109588 64354536
Pain in extremity 20.67 12.40 88 34520 302997 64161127
Idiopathic generalised epilepsy 20.51 12.40 5 34603 52 64464072
Dyspnoea exertional 20.45 12.40 7 34601 73723 64390401
Coordination abnormal 20.28 12.40 32 34576 14932 64449192
Exposure during pregnancy 20.23 12.40 89 34519 77586 64386538
Unmasking of previously unidentified disease 20.19 12.40 12 34596 1635 64462489
Screaming 20.04 12.40 16 34592 3513 64460611
Gastrointestinal haemorrhage 19.93 12.40 25 34583 132287 64331837
Postictal psychosis 19.72 12.40 6 34602 150 64463974
Delusion 19.71 12.40 35 34573 17979 64446145
Muscle twitching 19.63 12.40 36 34572 18962 64445162
Blood antidiuretic hormone decreased 19.59 12.40 3 34605 0 64464124
Tic 19.59 12.40 14 34594 2605 64461519
Lethargy 19.54 12.40 84 34524 72510 64391614
Hallucination 19.41 12.40 84 34524 72704 64391420
Depressed mood 19.27 12.40 57 34551 40955 64423169
Loss of consciousness 19.27 12.40 141 34467 148224 64315900
Dysphoria 18.97 12.40 17 34591 4371 64459753
Agranulocytosis 18.80 12.40 54 34554 38175 64425949
Sleep paralysis 18.58 12.40 8 34600 550 64463574
Haemoglobin decreased 18.52 12.40 49 34559 195014 64269110
Arthritis 18.50 12.40 11 34597 83803 64380321
Anticonvulsant drug level increased 18.46 12.40 13 34595 2364 64461760
Weight increased 18.35 12.40 185 34423 213163 64250961
Fear 18.10 12.40 36 34572 20135 64443989
Myocardial infarction 17.84 12.40 39 34569 165782 64298342
Alopecia 17.80 12.40 39 34569 165651 64298473
Product colour issue 17.62 12.40 8 34600 625 64463499
Mood altered 17.43 12.40 31 34577 15948 64448176
Nausea 17.42 12.40 307 34301 785493 63678631
Dystonia 17.33 12.40 34 34574 18831 64445293
Atonic seizures 17.24 12.40 8 34600 657 64463467
Condition aggravated 17.20 12.40 288 34320 372138 64091986
Normal newborn 17.19 12.40 18 34590 5599 64458525
Eye movement disorder 17.03 12.40 20 34588 7059 64457065
Renal failure 16.98 12.40 46 34562 181642 64282482
Nervousness 16.77 12.40 44 34564 29512 64434612
Head injury 16.74 12.40 47 34561 32795 64431329
Cardio-respiratory arrest 16.70 12.40 100 34508 98293 64365831
Enuresis 16.60 12.40 13 34595 2777 64461347
Epistaxis 16.45 12.40 17 34591 98114 64366010
Confusional state 16.40 12.40 213 34395 260931 64203193
Developmental coordination disorder 16.30 12.40 3 34605 6 64464118
Rasmussen encephalitis 16.30 12.40 3 34605 6 64464118
Electrocardiogram repolarisation abnormality 16.28 12.40 11 34597 1871 64462253
Musculoskeletal pain 16.15 12.40 12 34596 81282 64382842
Anxiety 16.13 12.40 173 34435 202476 64261648
Logorrhoea 16.13 12.40 15 34593 4044 64460080
Disorientation 16.11 12.40 66 34542 55762 64408362
Renal impairment 16.02 12.40 30 34578 134987 64329137
Atrioventricular block first degree 16.02 12.40 24 34584 10710 64453414
Hippocampal sclerosis 15.96 12.40 5 34603 138 64463986
Macule 15.96 12.40 12 34596 2414 64461710
Restlessness 15.66 12.40 52 34556 39733 64424391
Productive cough 15.61 12.40 10 34598 73193 64390931
Intestinal intraepithelial lymphocytes increased 15.44 12.40 3 34605 9 64464115
Asthma 15.40 12.40 17 34591 95208 64368916
Gamma-glutamyltransferase increased 15.33 12.40 59 34549 48451 64415673
Extensor plantar response 15.19 12.40 10 34598 1630 64462494
Drug screen positive 15.15 12.40 17 34591 5712 64458412
Lactic acidosis 15.12 12.40 7 34601 61403 64402721
Postictal state 15.11 12.40 10 34598 1643 64462481
Large granular lymphocytosis 14.99 12.40 6 34602 343 64463781
Neuropathy peripheral 14.95 12.40 25 34583 117500 64346624
Impaired healing 14.72 12.40 7 34601 60466 64403658
Abnormal sensation in eye 14.72 12.40 10 34598 1717 64462407
Crying 14.71 12.40 33 34575 20057 64444067
Rash maculo-papular 14.70 12.40 57 34551 46969 64417155
Blood chloride decreased 14.69 12.40 19 34589 7397 64456727
Hypersensitivity 14.67 12.40 55 34553 196397 64267727
Antipsychotic drug level decreased 14.58 12.40 8 34600 936 64463188
Nasal congestion 14.38 12.40 7 34601 59651 64404473
Mental status changes 14.38 12.40 68 34540 61094 64403030
Pancytopenia 14.37 12.40 35 34573 143274 64320850
Fever neonatal 14.23 12.40 3 34605 15 64464109
Libido decreased 14.05 12.40 15 34593 4769 64459355
Drop attacks 14.04 12.40 8 34600 1007 64463117
Ammonia increased 14.01 12.40 18 34590 6959 64457165
Fall 13.68 12.40 306 34302 416520 64047604
Therapeutic response unexpected 13.67 12.40 29 34579 16972 64447152
Social fear 13.63 12.40 3 34605 19 64464105
Discomfort 13.57 12.40 14 34594 80864 64383260
Systemic lupus erythematosus 13.52 12.40 13 34595 77599 64386525
Multiple organ dysfunction syndrome 13.44 12.40 21 34587 101392 64362732
Melaena 13.34 12.40 6 34602 53542 64410582
Poisoning deliberate 13.27 12.40 25 34583 13433 64450691
Erectile dysfunction 13.13 12.40 24 34584 12603 64451521
Follicular mucinosis 13.01 12.40 3 34605 24 64464100
Leukopenia 13.01 12.40 96 34512 101146 64362978
Immunodeficiency common variable 12.83 12.40 5 34603 266 64463858
Head banging 12.78 12.40 6 34602 506 64463618
Mucosal inflammation 12.74 12.40 9 34599 62575 64401549
Blood pressure fluctuation 12.63 12.40 6 34602 51865 64412259
Otitis media 12.53 12.40 15 34593 5398 64458726
Apathy 12.52 12.40 22 34586 11210 64452914
Ascites 12.51 12.40 9 34599 61992 64402132
Platelet count decreased 12.49 12.40 47 34561 167664 64296460

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N03AF02 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Carboxamide derivatives
FDA PE N0000008486 Decreased Central Nervous System Disorganized Electrical Activity
MeSH PA D000927 Anticonvulsants
MeSH PA D002317 Cardiovascular Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D065701 Cytochrome P-450 CYP3A Inducers
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D065606 Metabolic Side Effects of Drugs and Substances
MeSH PA D026941 Sodium Channel Blockers
MeSH PA D061567 Voltage-Gated Sodium Channel Blockers
CHEBI has role CHEBI:35623 anticonvulsants
CHEBI has role CHEBI:88188 allergenic drug
FDA EPC N0000175753 Anti-epileptic Agent

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Localization-related epilepsy indication 230381009 DOID:2234
Epilepsy characterized by intractable complex partial seizures indication 442481002
Simple partial seizure indication 117891000119100
Suicidal thoughts contraindication 6471006
Mood swings contraindication 18963009
Depressive disorder contraindication 35489007
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Acute nephropathy contraindication 58574008
Hyponatremia contraindication 89627008
Impaired renal function disorder contraindication 197663003




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.9 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
150MG OXTELLAR XR SUPERNUS PHARMS N202810 Oct. 19, 2012 RX TABLET, EXTENDED RELEASE ORAL 10220042 April 13, 2027 TREATMENT OF PARTIAL-ONSET SEIZURES
150MG OXTELLAR XR SUPERNUS PHARMS N202810 Oct. 19, 2012 RX TABLET, EXTENDED RELEASE ORAL 7910131 April 13, 2027 TREATMENT OF PARTIAL-ONSET SEIZURES
150MG OXTELLAR XR SUPERNUS PHARMS N202810 Oct. 19, 2012 RX TABLET, EXTENDED RELEASE ORAL 9119791 April 13, 2027 TREATMENT OF PARTIAL-ONSET SEIZURES
300MG OXTELLAR XR SUPERNUS PHARMS N202810 Oct. 19, 2012 RX TABLET, EXTENDED RELEASE ORAL 10220042 April 13, 2027 TREATMENT OF PARTIAL-ONSET SEIZURES
300MG OXTELLAR XR SUPERNUS PHARMS N202810 Oct. 19, 2012 RX TABLET, EXTENDED RELEASE ORAL 7910131 April 13, 2027 TREATMENT OF PARTIAL-ONSET SEIZURES
300MG OXTELLAR XR SUPERNUS PHARMS N202810 Oct. 19, 2012 RX TABLET, EXTENDED RELEASE ORAL 9119791 April 13, 2027 TREATMENT OF PARTIAL-ONSET SEIZURES
600MG OXTELLAR XR SUPERNUS PHARMS N202810 Oct. 19, 2012 RX TABLET, EXTENDED RELEASE ORAL 10220042 April 13, 2027 TREATMENT OF PARTIAL-ONSET SEIZURES
600MG OXTELLAR XR SUPERNUS PHARMS N202810 Oct. 19, 2012 RX TABLET, EXTENDED RELEASE ORAL 7910131 April 13, 2027 TREATMENT OF PARTIAL-ONSET SEIZURES
600MG OXTELLAR XR SUPERNUS PHARMS N202810 Oct. 19, 2012 RX TABLET, EXTENDED RELEASE ORAL 9119791 April 13, 2027 TREATMENT OF PARTIAL-ONSET SEIZURES

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium channel protein type 5 subunit alpha Ion channel BLOCKER WOMBAT-PK CHEMBL

External reference:

IDSource
4021196 VUID
N0000148642 NUI
D00533 KEGG_DRUG
4021196 VANDF
C0069751 UMLSCUI
CHEBI:7824 CHEBI
CHEMBL1068 ChEMBL_ID
DB00776 DRUGBANK_ID
D000078330 MESH_DESCRIPTOR_UI
34312 PUBCHEM_CID
7254 IUPHAR_LIGAND_ID
4585 INN_ID
VZI5B1W380 UNII
32624 RXNORM
121517 MMSL
8631 MMSL
d04513 MMSL
006035 NDDF
116511002 SNOMEDCT_US
387025007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Oxcarbazepine HUMAN PRESCRIPTION DRUG LABEL 1 0054-0199 SUSPENSION 300 mg ORAL ANDA 30 sections
Trileptal HUMAN PRESCRIPTION DRUG LABEL 1 0078-0337 TABLET, FILM COATED 300 mg ORAL NDA 33 sections
Trileptal HUMAN PRESCRIPTION DRUG LABEL 1 0078-0357 SUSPENSION 60 mg ORAL NDA 33 sections
Trileptal HUMAN PRESCRIPTION DRUG LABEL 1 0078-0456 TABLET, FILM COATED 150 mg ORAL NDA 33 sections
Trileptal HUMAN PRESCRIPTION DRUG LABEL 1 0078-0457 TABLET, FILM COATED 600 mg ORAL NDA 33 sections
Oxcarbazepine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8153 TABLET, FILM COATED 150 mg ORAL ANDA 30 sections
Oxcarbazepine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8292 TABLET, FILM COATED 300 mg ORAL ANDA 30 sections
Oxcarbazepine HUMAN PRESCRIPTION DRUG LABEL 1 0781-6270 SUSPENSION 60 mg ORAL NDA authorized generic 31 sections
OXTELLAR XR HUMAN PRESCRIPTION DRUG LABEL 1 17772-121 TABLET 150 mg ORAL NDA 34 sections
OXTELLAR XR HUMAN PRESCRIPTION DRUG LABEL 1 17772-121 TABLET 150 mg ORAL NDA 34 sections
OXTELLAR XR HUMAN PRESCRIPTION DRUG LABEL 1 17772-122 TABLET 300 mg ORAL NDA 34 sections
OXTELLAR XR HUMAN PRESCRIPTION DRUG LABEL 1 17772-122 TABLET 300 mg ORAL NDA 34 sections
OXTELLAR XR HUMAN PRESCRIPTION DRUG LABEL 1 17772-123 TABLET 600 mg ORAL NDA 34 sections
OXTELLAR XR HUMAN PRESCRIPTION DRUG LABEL 1 17772-123 TABLET 600 mg ORAL NDA 34 sections
Oxcarbazepine HUMAN PRESCRIPTION DRUG LABEL 1 21695-862 TABLET, FILM COATED 150 mg ORAL ANDA 30 sections
Oxcarbazepine HUMAN PRESCRIPTION DRUG LABEL 1 21695-863 TABLET, FILM COATED 300 mg ORAL ANDA 30 sections
Oxcarbazepine HUMAN PRESCRIPTION DRUG LABEL 1 21695-864 TABLET, FILM COATED 600 mg ORAL ANDA 30 sections
Oxcarbazepine HUMAN PRESCRIPTION DRUG LABEL 1 31722-023 TABLET, FILM COATED 150 mg ORAL ANDA 28 sections
Oxcarbazepine HUMAN PRESCRIPTION DRUG LABEL 1 31722-024 TABLET, FILM COATED 300 mg ORAL ANDA 28 sections
Oxcarbazepine HUMAN PRESCRIPTION DRUG LABEL 1 31722-025 TABLET, FILM COATED 600 mg ORAL ANDA 28 sections
Oxcarbazepine HUMAN PRESCRIPTION DRUG LABEL 1 33261-684 TABLET, FILM COATED 150 mg ORAL ANDA 29 sections
Oxcarbazepine HUMAN PRESCRIPTION DRUG LABEL 1 33261-841 TABLET, FILM COATED 300 mg ORAL ANDA 29 sections
Oxcarbazepine HUMAN PRESCRIPTION DRUG LABEL 1 33261-842 TABLET, FILM COATED 600 mg ORAL ANDA 29 sections
OXCARBAZEPINE HUMAN PRESCRIPTION DRUG LABEL 1 50090-5003 TABLET, FILM COATED 300 mg ORAL ANDA 32 sections
Oxcarbazepine HUMAN PRESCRIPTION DRUG LABEL 1 50268-649 SUSPENSION 300 mg ORAL ANDA 19 sections
Oxcarbazepine HUMAN PRESCRIPTION DRUG LABEL 1 50383-312 SUSPENSION 300 mg ORAL ANDA 29 sections
Oxcarbazepine HUMAN PRESCRIPTION DRUG LABEL 1 50383-312 SUSPENSION 300 mg ORAL ANDA 29 sections
Oxcarbazepine HUMAN PRESCRIPTION DRUG LABEL 1 51672-4105 TABLET 150 mg ORAL ANDA 35 sections
Oxcarbazepine HUMAN PRESCRIPTION DRUG LABEL 1 51672-4106 TABLET 300 mg ORAL ANDA 35 sections
Oxcarbazepine HUMAN PRESCRIPTION DRUG LABEL 1 51672-4107 TABLET 600 mg ORAL ANDA 35 sections