Stem definition | Drug id | CAS RN |
---|---|---|
tricyclic compounds | 2017 | 28721-07-5 |
Dose | Unit | Route |
---|---|---|
1 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.09 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 135.90 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 95 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
Jan. 14, 2000 | FDA | NOVARTIS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Seizure | 1109.36 | 13.01 | 714 | 25566 | 117160 | 50461684 |
Hyponatraemia | 548.58 | 13.01 | 430 | 25850 | 95709 | 50483135 |
Abortion spontaneous | 253.29 | 13.01 | 194 | 26086 | 41578 | 50537266 |
Generalised tonic-clonic seizure | 183.60 | 13.01 | 133 | 26147 | 26177 | 50552667 |
Status epilepticus | 165.64 | 13.01 | 97 | 26183 | 13309 | 50565535 |
Epilepsy | 164.24 | 13.01 | 115 | 26165 | 21452 | 50557392 |
Focal dyscognitive seizures | 162.42 | 13.01 | 59 | 26221 | 2673 | 50576171 |
Diplopia | 156.78 | 13.01 | 107 | 26173 | 19153 | 50559691 |
Completed suicide | 141.51 | 13.01 | 249 | 26031 | 131640 | 50447204 |
Petit mal epilepsy | 134.26 | 13.01 | 54 | 26226 | 3235 | 50575609 |
Product substitution issue | 121.34 | 13.01 | 81 | 26199 | 13976 | 50564868 |
Aggression | 119.06 | 13.01 | 94 | 26186 | 21022 | 50557822 |
Psychogenic seizure | 116.19 | 13.01 | 40 | 26240 | 1545 | 50577299 |
Somnolence | 108.73 | 13.01 | 245 | 26035 | 154740 | 50424104 |
Drug interaction | 100.48 | 13.01 | 278 | 26002 | 199343 | 50379501 |
Exposure during pregnancy | 98.25 | 13.01 | 203 | 26077 | 120812 | 50458032 |
Inappropriate antidiuretic hormone secretion | 97.53 | 13.01 | 69 | 26211 | 13074 | 50565770 |
Blood sodium decreased | 95.96 | 13.01 | 83 | 26197 | 21064 | 50557780 |
Psychotic disorder | 85.85 | 13.01 | 79 | 26201 | 21733 | 50557111 |
Multiple-drug resistance | 78.26 | 13.01 | 37 | 26243 | 3277 | 50575567 |
Abnormal behaviour | 75.05 | 13.01 | 70 | 26210 | 19588 | 50559256 |
Mitochondrial DNA mutation | 70.91 | 13.01 | 18 | 26262 | 232 | 50578612 |
Irritability | 68.35 | 13.01 | 79 | 26201 | 28347 | 50550497 |
Propofol infusion syndrome | 66.69 | 13.01 | 22 | 26258 | 744 | 50578100 |
Suicide attempt | 65.11 | 13.01 | 105 | 26175 | 51627 | 50527217 |
Partial seizures | 64.86 | 13.01 | 37 | 26243 | 4828 | 50574016 |
Mania | 64.56 | 13.01 | 50 | 26230 | 10866 | 50567978 |
Joint swelling | 63.53 | 13.01 | 24 | 26256 | 245262 | 50333582 |
Ataxia | 62.31 | 13.01 | 54 | 26226 | 13732 | 50565112 |
Hyperammonaemic encephalopathy | 62.03 | 13.01 | 27 | 26253 | 1972 | 50576872 |
Myoclonic epilepsy | 61.49 | 13.01 | 22 | 26258 | 953 | 50577891 |
Balance disorder | 59.09 | 13.01 | 120 | 26160 | 70470 | 50508374 |
Infantile spasms | 58.83 | 13.01 | 15 | 26265 | 197 | 50578647 |
Dizziness | 58.13 | 13.01 | 342 | 25938 | 346027 | 50232817 |
Suicidal ideation | 57.26 | 13.01 | 103 | 26177 | 55282 | 50523562 |
Infusion related reaction | 56.42 | 13.01 | 10 | 26270 | 169547 | 50409297 |
Maternal exposure during pregnancy | 53.98 | 13.01 | 194 | 26086 | 159584 | 50419260 |
Contraindicated product administered | 53.63 | 13.01 | 7 | 26273 | 148951 | 50429893 |
Hypochloraemia | 53.58 | 13.01 | 23 | 26257 | 1624 | 50577220 |
Speech disorder | 52.93 | 13.01 | 78 | 26202 | 35470 | 50543374 |
Arthralgia | 52.75 | 13.01 | 92 | 26188 | 438610 | 50140234 |
Nystagmus | 52.74 | 13.01 | 34 | 26246 | 5527 | 50573317 |
Drug reaction with eosinophilia and systemic symptoms | 49.16 | 13.01 | 67 | 26213 | 28357 | 50550487 |
Bipolar disorder | 49.03 | 13.01 | 35 | 26245 | 6722 | 50572122 |
Glossodynia | 48.09 | 13.01 | 3 | 26277 | 115566 | 50463278 |
Nasopharyngitis | 48.09 | 13.01 | 20 | 26260 | 192907 | 50385937 |
Peripheral swelling | 47.22 | 13.01 | 24 | 26256 | 205912 | 50372932 |
Tremor | 47.17 | 13.01 | 149 | 26131 | 114754 | 50464090 |
Intentional overdose | 46.20 | 13.01 | 101 | 26179 | 62403 | 50516441 |
Gene mutation | 45.50 | 13.01 | 19 | 26261 | 1252 | 50577592 |
Toxicity to various agents | 45.18 | 13.01 | 224 | 26056 | 212275 | 50366569 |
Diarrhoea | 45.13 | 13.01 | 156 | 26124 | 588320 | 49990524 |
Sudden unexplained death in epilepsy | 44.98 | 13.01 | 13 | 26267 | 280 | 50578564 |
Sedation | 43.90 | 13.01 | 66 | 26214 | 30544 | 50548300 |
Anticonvulsant drug level decreased | 43.59 | 13.01 | 18 | 26262 | 1153 | 50577691 |
Arthropathy | 43.34 | 13.01 | 14 | 26266 | 157892 | 50420952 |
Drug level decreased | 43.22 | 13.01 | 32 | 26248 | 6501 | 50572343 |
Agitation | 42.60 | 13.01 | 89 | 26191 | 53295 | 50525549 |
Blood gases abnormal | 42.50 | 13.01 | 15 | 26265 | 624 | 50578220 |
Infection | 41.40 | 13.01 | 19 | 26261 | 172935 | 50405909 |
Memory impairment | 40.28 | 13.01 | 111 | 26169 | 79249 | 50499595 |
Systemic lupus erythematosus | 39.43 | 13.01 | 12 | 26268 | 140610 | 50438234 |
Pain | 38.84 | 13.01 | 162 | 26118 | 578741 | 50000103 |
Swelling | 38.30 | 13.01 | 29 | 26251 | 200843 | 50378001 |
Gastric lavage | 37.87 | 13.01 | 8 | 26272 | 42 | 50578802 |
Alopecia | 37.74 | 13.01 | 43 | 26237 | 245004 | 50333840 |
Tonic convulsion | 37.36 | 13.01 | 16 | 26264 | 1123 | 50577721 |
Depression | 37.02 | 13.01 | 177 | 26103 | 165246 | 50413598 |
Simple partial seizures | 36.99 | 13.01 | 13 | 26267 | 534 | 50578310 |
Paradoxical drug reaction | 36.33 | 13.01 | 23 | 26257 | 3624 | 50575220 |
Rheumatoid arthritis | 35.21 | 13.01 | 32 | 26248 | 202518 | 50376326 |
Respiratory arrest | 35.17 | 13.01 | 59 | 26221 | 29950 | 50548894 |
Pneumonia | 34.90 | 13.01 | 92 | 26188 | 378309 | 50200535 |
Cross sensitivity reaction | 34.65 | 13.01 | 18 | 26262 | 1951 | 50576893 |
Pregnancy | 34.46 | 13.01 | 58 | 26222 | 29519 | 50549325 |
Cough | 34.34 | 13.01 | 45 | 26235 | 241219 | 50337625 |
Febrile neutropenia | 31.95 | 13.01 | 6 | 26274 | 97661 | 50481183 |
Dyskinesia | 31.62 | 13.01 | 54 | 26226 | 27807 | 50551037 |
Hypothermia | 31.61 | 13.01 | 35 | 26245 | 11981 | 50566863 |
Abortion induced | 31.36 | 13.01 | 31 | 26249 | 9313 | 50569531 |
Partial seizures with secondary generalisation | 30.96 | 13.01 | 10 | 26270 | 316 | 50578528 |
Sinusitis | 30.78 | 13.01 | 26 | 26254 | 170532 | 50408312 |
Aphasia | 30.73 | 13.01 | 54 | 26226 | 28440 | 50550404 |
Dyspnoea | 30.39 | 13.01 | 164 | 26116 | 547444 | 50031400 |
Electroencephalogram abnormal | 29.79 | 13.01 | 20 | 26260 | 3479 | 50575365 |
Unmasking of previously unidentified disease | 29.10 | 13.01 | 12 | 26268 | 766 | 50578078 |
Cognitive disorder | 28.92 | 13.01 | 68 | 26212 | 44055 | 50534789 |
Stevens-Johnson syndrome | 28.52 | 13.01 | 45 | 26235 | 21707 | 50557137 |
Blood osmolarity decreased | 28.19 | 13.01 | 12 | 26268 | 830 | 50578014 |
Trigeminal neuralgia | 26.99 | 13.01 | 18 | 26262 | 3097 | 50575747 |
Neuroleptic malignant syndrome | 26.86 | 13.01 | 31 | 26249 | 11099 | 50567745 |
Brown tumour | 26.80 | 13.01 | 6 | 26274 | 43 | 50578801 |
Mental disorder | 26.79 | 13.01 | 44 | 26236 | 21947 | 50556897 |
Electrocardiogram QRS complex prolonged | 26.33 | 13.01 | 22 | 26258 | 5322 | 50573522 |
Anaemia | 25.90 | 13.01 | 58 | 26222 | 252398 | 50326446 |
Neurotoxicity | 25.87 | 13.01 | 35 | 26245 | 14705 | 50564139 |
Overdose | 25.48 | 13.01 | 111 | 26169 | 99616 | 50479228 |
Dysmorphism | 24.98 | 13.01 | 15 | 26265 | 2152 | 50576692 |
Multiple sclerosis | 24.96 | 13.01 | 41 | 26239 | 20452 | 50558392 |
Atonic seizures | 24.81 | 13.01 | 10 | 26270 | 602 | 50578242 |
Low set ears | 24.49 | 13.01 | 8 | 26272 | 262 | 50578582 |
Coma blister | 24.34 | 13.01 | 7 | 26273 | 148 | 50578696 |
Change in seizure presentation | 24.32 | 13.01 | 8 | 26272 | 268 | 50578576 |
Lennox-Gastaut syndrome | 24.29 | 13.01 | 8 | 26272 | 269 | 50578575 |
Bipolar I disorder | 24.23 | 13.01 | 13 | 26267 | 1505 | 50577339 |
Catatonia | 24.04 | 13.01 | 18 | 26262 | 3718 | 50575126 |
Drug ineffective for unapproved indication | 23.82 | 13.01 | 41 | 26239 | 21240 | 50557604 |
Parkinsonism | 23.67 | 13.01 | 26 | 26254 | 8821 | 50570023 |
Aura | 23.34 | 13.01 | 11 | 26269 | 967 | 50577877 |
Atrial fibrillation | 23.08 | 13.01 | 12 | 26268 | 101733 | 50477111 |
Therapeutic product effective for unapproved indication | 22.92 | 13.01 | 6 | 26274 | 88 | 50578756 |
Discomfort | 22.84 | 13.01 | 14 | 26266 | 108366 | 50470478 |
Drug withdrawal convulsions | 22.76 | 13.01 | 12 | 26268 | 1341 | 50577503 |
Drug level increased | 22.73 | 13.01 | 38 | 26242 | 19230 | 50559614 |
Psychomotor hyperactivity | 22.60 | 13.01 | 26 | 26254 | 9275 | 50569569 |
Poisoning | 22.56 | 13.01 | 30 | 26250 | 12399 | 50566445 |
Tardive dyskinesia | 22.32 | 13.01 | 23 | 26257 | 7256 | 50571588 |
Dysphoria | 22.18 | 13.01 | 19 | 26261 | 4755 | 50574089 |
Therapeutic product ineffective for unapproved indication | 22.18 | 13.01 | 7 | 26273 | 205 | 50578639 |
Renal impairment | 22.04 | 13.01 | 6 | 26274 | 75655 | 50503189 |
Muscle twitching | 21.73 | 13.01 | 33 | 26247 | 15398 | 50563446 |
Blood lactic acid increased | 21.52 | 13.01 | 20 | 26260 | 5565 | 50573279 |
Stomatitis | 21.48 | 13.01 | 13 | 26267 | 101331 | 50477513 |
Loss of consciousness | 21.42 | 13.01 | 109 | 26171 | 104244 | 50474600 |
Impaired healing | 21.36 | 13.01 | 5 | 26275 | 69781 | 50509063 |
Treatment failure | 21.33 | 13.01 | 24 | 26256 | 137613 | 50441231 |
Electrocardiogram repolarisation abnormality | 21.20 | 13.01 | 11 | 26269 | 1189 | 50577655 |
Ventricular hypokinesia | 20.89 | 13.01 | 17 | 26263 | 3963 | 50574881 |
Chronic papillomatous dermatitis | 20.59 | 13.01 | 5 | 26275 | 53 | 50578791 |
Sopor | 20.57 | 13.01 | 37 | 26243 | 19842 | 50559002 |
Hallucination | 20.51 | 13.01 | 62 | 26218 | 46595 | 50532249 |
Normal newborn | 20.26 | 13.01 | 21 | 26259 | 6670 | 50572174 |
Drug withdrawal syndrome | 20.22 | 13.01 | 42 | 26238 | 25039 | 50553805 |
Intentional self-injury | 20.17 | 13.01 | 40 | 26240 | 23072 | 50555772 |
Gaze palsy | 20.12 | 13.01 | 11 | 26269 | 1322 | 50577522 |
Crying | 19.86 | 13.01 | 37 | 26243 | 20379 | 50558465 |
General physical health deterioration | 19.80 | 13.01 | 27 | 26253 | 142407 | 50436437 |
Atrioventricular block first degree | 19.75 | 13.01 | 20 | 26260 | 6181 | 50572663 |
Follicular mucinosis | 19.69 | 13.01 | 3 | 26277 | 0 | 50578844 |
Congenital epiglottal anomaly | 19.69 | 13.01 | 3 | 26277 | 0 | 50578844 |
Strabismus | 19.38 | 13.01 | 12 | 26268 | 1818 | 50577026 |
Brain operation | 19.34 | 13.01 | 8 | 26272 | 515 | 50578329 |
Abdominal discomfort | 19.33 | 13.01 | 59 | 26221 | 231582 | 50347262 |
Coma | 19.11 | 13.01 | 69 | 26211 | 56810 | 50522034 |
Phobia | 19.10 | 13.01 | 7 | 26273 | 325 | 50578519 |
Systolic dysfunction | 19.10 | 13.01 | 11 | 26269 | 1461 | 50577383 |
Visual impairment | 18.99 | 13.01 | 78 | 26202 | 68197 | 50510647 |
Mood altered | 18.97 | 13.01 | 28 | 26252 | 12745 | 50566099 |
Caesarean section | 18.66 | 13.01 | 31 | 26249 | 15608 | 50563236 |
Electrocardiogram ST segment elevation | 18.58 | 13.01 | 15 | 26265 | 3458 | 50575386 |
Hypotonia | 18.54 | 13.01 | 22 | 26258 | 8112 | 50570732 |
Screaming | 18.39 | 13.01 | 14 | 26266 | 2964 | 50575880 |
Acute kidney injury | 18.39 | 13.01 | 59 | 26221 | 227999 | 50350845 |
Drug intolerance | 18.15 | 13.01 | 56 | 26224 | 219048 | 50359796 |
Neonatal seizure | 18.14 | 13.01 | 7 | 26273 | 375 | 50578469 |
Drug resistance | 17.96 | 13.01 | 34 | 26246 | 18955 | 50559889 |
Head injury | 17.94 | 13.01 | 39 | 26241 | 23981 | 50554863 |
Ammonia increased | 17.94 | 13.01 | 16 | 26264 | 4225 | 50574619 |
Seizure cluster | 17.83 | 13.01 | 6 | 26274 | 216 | 50578628 |
Hypersensitivity | 17.81 | 13.01 | 55 | 26225 | 215106 | 50363738 |
Therapeutic product effect decreased | 17.72 | 13.01 | 27 | 26253 | 136023 | 50442821 |
Poisoning deliberate | 17.37 | 13.01 | 21 | 26259 | 7891 | 50570953 |
Paranoia | 17.30 | 13.01 | 24 | 26256 | 10324 | 50568520 |
Anger | 17.05 | 13.01 | 25 | 26255 | 11308 | 50567536 |
Epistaxis | 16.96 | 13.01 | 6 | 26274 | 63948 | 50514896 |
Therapeutic response unexpected | 16.95 | 13.01 | 30 | 26250 | 15885 | 50562959 |
Stillbirth | 16.81 | 13.01 | 18 | 26262 | 5934 | 50572910 |
Logorrhoea | 16.77 | 13.01 | 12 | 26268 | 2312 | 50576532 |
Death | 16.61 | 13.01 | 100 | 26180 | 325279 | 50253565 |
Immunodeficiency common variable | 16.59 | 13.01 | 5 | 26275 | 125 | 50578719 |
Disturbance in attention | 16.19 | 13.01 | 44 | 26236 | 31142 | 50547702 |
Anticonvulsant drug level above therapeutic | 16.15 | 13.01 | 7 | 26273 | 506 | 50578338 |
Thyroxine free decreased | 15.95 | 13.01 | 7 | 26273 | 521 | 50578323 |
Sleep paralysis | 15.90 | 13.01 | 7 | 26273 | 525 | 50578319 |
Arthritis | 15.90 | 13.01 | 13 | 26267 | 86708 | 50492136 |
Restlessness | 15.63 | 13.01 | 38 | 26242 | 25135 | 50553709 |
Malignant neoplasm progression | 15.50 | 13.01 | 8 | 26272 | 68116 | 50510728 |
Pain in extremity | 15.47 | 13.01 | 81 | 26199 | 272784 | 50306060 |
Delusion | 15.45 | 13.01 | 23 | 26257 | 10546 | 50568298 |
Automatism | 15.39 | 13.01 | 4 | 26276 | 57 | 50578787 |
Coordination abnormal | 15.31 | 13.01 | 24 | 26256 | 11510 | 50567334 |
Pleural effusion | 15.20 | 13.01 | 12 | 26268 | 81442 | 50497402 |
Hallucination, auditory | 15.19 | 13.01 | 23 | 26257 | 10705 | 50568139 |
Dyspnoea exertional | 15.04 | 13.01 | 4 | 26276 | 51229 | 50527615 |
Sepsis | 14.91 | 13.01 | 29 | 26251 | 132896 | 50445948 |
Learning disorder | 14.90 | 13.01 | 7 | 26273 | 611 | 50578233 |
Cardiac arrest | 14.86 | 13.01 | 84 | 26196 | 83567 | 50495277 |
Cardiopulmonary failure | 14.81 | 13.01 | 13 | 26267 | 3360 | 50575484 |
Educational problem | 14.70 | 13.01 | 6 | 26274 | 373 | 50578471 |
Condition aggravated | 14.66 | 13.01 | 226 | 26054 | 296832 | 50282012 |
Cardio-respiratory arrest | 14.54 | 13.01 | 61 | 26219 | 53831 | 50525013 |
Fatigue | 14.43 | 13.01 | 270 | 26010 | 707331 | 49871513 |
Social fear | 14.32 | 13.01 | 3 | 26277 | 15 | 50578829 |
Behaviour disorder | 14.28 | 13.01 | 11 | 26269 | 2369 | 50576475 |
Product complaint | 14.04 | 13.01 | 23 | 26257 | 11443 | 50567401 |
Fall | 14.02 | 13.01 | 248 | 26032 | 334684 | 50244160 |
Productive cough | 13.88 | 13.01 | 5 | 26275 | 52689 | 50526155 |
Herpes zoster | 13.76 | 13.01 | 10 | 26270 | 70776 | 50508068 |
Immune thrombocytopenia | 13.72 | 13.01 | 20 | 26260 | 8997 | 50569847 |
Hyperkalaemia | 13.66 | 13.01 | 4 | 26276 | 48085 | 50530759 |
Fever neonatal | 13.59 | 13.01 | 3 | 26277 | 20 | 50578824 |
Gun shot wound | 13.55 | 13.01 | 4 | 26276 | 93 | 50578751 |
Granulocytopenia | 13.35 | 13.01 | 15 | 26265 | 5216 | 50573628 |
Irritable bowel syndrome | 13.34 | 13.01 | 5 | 26275 | 51436 | 50527408 |
Extensor plantar response | 13.33 | 13.01 | 8 | 26272 | 1146 | 50577698 |
Nasal congestion | 13.21 | 13.01 | 5 | 26275 | 51115 | 50527729 |
Amenorrhoea | 13.18 | 13.01 | 19 | 26261 | 8465 | 50570379 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Seizure | 1000.81 | 14.24 | 654 | 17687 | 92469 | 29463717 |
Hyponatraemia | 324.14 | 14.24 | 295 | 18046 | 67338 | 29488848 |
Product substitution issue | 186.89 | 14.24 | 98 | 18243 | 9074 | 29547112 |
Aggression | 181.72 | 14.24 | 161 | 18180 | 35380 | 29520806 |
Generalised tonic-clonic seizure | 158.32 | 14.24 | 115 | 18226 | 19024 | 29537162 |
Epilepsy | 135.10 | 14.24 | 103 | 18238 | 18329 | 29537857 |
Status epilepticus | 125.31 | 14.24 | 80 | 18261 | 10714 | 29545472 |
Somnolence | 106.72 | 14.24 | 201 | 18140 | 93754 | 29462432 |
Partial seizures | 103.89 | 14.24 | 50 | 18291 | 3853 | 29552333 |
Sudden unexplained death in epilepsy | 100.97 | 14.24 | 28 | 18313 | 428 | 29555758 |
Drug ineffective | 99.66 | 14.24 | 466 | 17875 | 362704 | 29193482 |
Multiple-drug resistance | 97.90 | 14.24 | 48 | 18293 | 3852 | 29552334 |
Stevens-Johnson syndrome | 92.84 | 14.24 | 79 | 18262 | 16418 | 29539768 |
Petit mal epilepsy | 88.34 | 14.24 | 40 | 18301 | 2682 | 29553504 |
Nystagmus | 70.95 | 14.24 | 40 | 18301 | 4269 | 29551917 |
Ataxia | 70.23 | 14.24 | 59 | 18282 | 12044 | 29544142 |
Death | 68.50 | 14.24 | 67 | 18274 | 342017 | 29214169 |
Abnormal behaviour | 66.85 | 14.24 | 77 | 18264 | 23050 | 29533136 |
Inappropriate antidiuretic hormone secretion | 64.89 | 14.24 | 54 | 18287 | 10878 | 29545308 |
Drug interaction | 63.43 | 14.24 | 266 | 18075 | 197119 | 29359067 |
Intellectual disability | 57.87 | 14.24 | 23 | 18318 | 1114 | 29555072 |
Acute kidney injury | 57.76 | 14.24 | 48 | 18293 | 265219 | 29290967 |
Electroencephalogram abnormal | 56.40 | 14.24 | 28 | 18313 | 2307 | 29553879 |
Pneumonia | 53.96 | 14.24 | 72 | 18269 | 320100 | 29236086 |
Behaviour disorder | 50.07 | 14.24 | 30 | 18311 | 3586 | 29552600 |
Irritability | 49.84 | 14.24 | 65 | 18276 | 22087 | 29534099 |
Febrile neutropenia | 49.01 | 14.24 | 6 | 18335 | 112234 | 29443952 |
Dyspnoea | 46.85 | 14.24 | 82 | 18259 | 326650 | 29229536 |
Focal dyscognitive seizures | 45.85 | 14.24 | 20 | 18321 | 1226 | 29554960 |
Anaemia | 44.13 | 14.24 | 36 | 18305 | 200915 | 29355271 |
Memory impairment | 43.77 | 14.24 | 80 | 18261 | 36390 | 29519796 |
Cognitive disorder | 42.41 | 14.24 | 62 | 18279 | 23437 | 29532749 |
Agitation | 40.85 | 14.24 | 95 | 18246 | 51209 | 29504977 |
Myoclonic epilepsy | 40.33 | 14.24 | 17 | 18324 | 958 | 29555228 |
Blood sodium decreased | 39.07 | 14.24 | 47 | 18294 | 14720 | 29541466 |
Educational problem | 38.94 | 14.24 | 14 | 18327 | 513 | 29555673 |
Coma | 38.15 | 14.24 | 79 | 18262 | 39371 | 29516815 |
Diarrhoea | 37.21 | 14.24 | 96 | 18245 | 332602 | 29223584 |
Colitis ischaemic | 37.15 | 14.24 | 30 | 18311 | 5793 | 29550393 |
Hyperammonaemic encephalopathy | 36.95 | 14.24 | 20 | 18321 | 1970 | 29554216 |
Psychomotor hyperactivity | 35.66 | 14.24 | 34 | 18307 | 8179 | 29548007 |
Intentional self-injury | 35.18 | 14.24 | 41 | 18300 | 12420 | 29543766 |
Hypochloraemia | 34.84 | 14.24 | 13 | 18328 | 530 | 29555656 |
Psychotic disorder | 34.28 | 14.24 | 52 | 18289 | 20302 | 29535884 |
Drug level decreased | 33.27 | 14.24 | 29 | 18312 | 6218 | 29549968 |
Autism spectrum disorder | 31.13 | 14.24 | 18 | 18323 | 2014 | 29554172 |
Autonomic nervous system imbalance | 31.06 | 14.24 | 19 | 18322 | 2357 | 29553829 |
Simple partial seizures | 30.99 | 14.24 | 10 | 18331 | 262 | 29555924 |
Speech disorder developmental | 29.50 | 14.24 | 17 | 18324 | 1890 | 29554296 |
Aura | 29.28 | 14.24 | 10 | 18331 | 314 | 29555872 |
Cardiac failure congestive | 29.13 | 14.24 | 6 | 18335 | 76575 | 29479611 |
Depressed mood | 29.10 | 14.24 | 43 | 18298 | 16405 | 29539781 |
Sepsis | 28.37 | 14.24 | 28 | 18313 | 142654 | 29413532 |
Disturbance in attention | 28.27 | 14.24 | 49 | 18292 | 21375 | 29534811 |
Diplopia | 27.84 | 14.24 | 38 | 18303 | 13480 | 29542706 |
Completed suicide | 27.61 | 14.24 | 120 | 18221 | 90126 | 29466060 |
Depression | 27.42 | 14.24 | 115 | 18226 | 85032 | 29471154 |
Suicidal ideation | 27.30 | 14.24 | 64 | 18277 | 34652 | 29521534 |
Anticonvulsant drug level decreased | 26.95 | 14.24 | 13 | 18328 | 1006 | 29555180 |
Affective disorder | 26.31 | 14.24 | 19 | 18322 | 3107 | 29553079 |
Hallucination, auditory | 26.14 | 14.24 | 31 | 18310 | 9562 | 29546624 |
Developmental coordination disorder | 26.07 | 14.24 | 8 | 18333 | 177 | 29556009 |
Dissociation | 25.68 | 14.24 | 13 | 18328 | 1116 | 29555070 |
Hypothermia | 25.41 | 14.24 | 30 | 18311 | 9209 | 29546977 |
Drug withdrawal convulsions | 25.34 | 14.24 | 13 | 18328 | 1148 | 29555038 |
Anxiety | 24.96 | 14.24 | 112 | 18229 | 85253 | 29470933 |
Tic | 24.83 | 14.24 | 15 | 18326 | 1820 | 29554366 |
Otitis media | 24.73 | 14.24 | 17 | 18324 | 2572 | 29553614 |
Brain malformation | 24.66 | 14.24 | 7 | 18334 | 117 | 29556069 |
Platelet count decreased | 23.89 | 14.24 | 18 | 18323 | 104654 | 29451532 |
Irregular sleep phase | 23.88 | 14.24 | 6 | 18335 | 61 | 29556125 |
Thyroxine free decreased | 23.52 | 14.24 | 8 | 18333 | 248 | 29555938 |
Enuresis | 23.07 | 14.24 | 15 | 18326 | 2069 | 29554117 |
Sopor | 22.91 | 14.24 | 31 | 18310 | 10903 | 29545283 |
Coordination abnormal | 22.79 | 14.24 | 25 | 18316 | 7089 | 29549097 |
Condition aggravated | 22.79 | 14.24 | 162 | 18179 | 146133 | 29410053 |
Dysmorphism | 22.62 | 14.24 | 17 | 18324 | 2954 | 29553232 |
Gait disturbance | 22.02 | 14.24 | 97 | 18244 | 73252 | 29482934 |
Hyperammonaemia | 21.89 | 14.24 | 22 | 18319 | 5641 | 29550545 |
Wrong patient received product | 21.83 | 14.24 | 15 | 18326 | 2267 | 29553919 |
Impulsive behaviour | 21.55 | 14.24 | 14 | 18327 | 1929 | 29554257 |
Balance disorder | 21.50 | 14.24 | 60 | 18281 | 36110 | 29520076 |
Speech disorder | 21.45 | 14.24 | 46 | 18295 | 23470 | 29532716 |
Trigeminal neuralgia | 21.03 | 14.24 | 11 | 18330 | 1011 | 29555175 |
Psychogenic seizure | 20.90 | 14.24 | 8 | 18333 | 350 | 29555836 |
Pancytopenia | 20.70 | 14.24 | 13 | 18328 | 83155 | 29473031 |
Nervousness | 20.64 | 14.24 | 30 | 18311 | 11276 | 29544910 |
Renal failure | 20.58 | 14.24 | 26 | 18315 | 118573 | 29437613 |
Idiopathic generalised epilepsy | 20.55 | 14.24 | 5 | 18336 | 44 | 29556142 |
Gastrointestinal haemorrhage | 20.40 | 14.24 | 12 | 18329 | 79521 | 29476665 |
Bradykinesia | 20.39 | 14.24 | 17 | 18324 | 3430 | 29552756 |
Seizure cluster | 20.22 | 14.24 | 6 | 18335 | 118 | 29556068 |
Neuroleptic malignant syndrome | 20.10 | 14.24 | 36 | 18305 | 16112 | 29540074 |
Arthralgia | 19.96 | 14.24 | 35 | 18306 | 139582 | 29416604 |
Overweight | 19.94 | 14.24 | 12 | 18329 | 1446 | 29554740 |
Dizziness | 19.85 | 14.24 | 192 | 18149 | 189492 | 29366694 |
Oedema peripheral | 19.80 | 14.24 | 21 | 18320 | 103536 | 29452650 |
Psychomotor skills impaired | 19.76 | 14.24 | 15 | 18326 | 2646 | 29553540 |
Motor developmental delay | 19.23 | 14.24 | 9 | 18332 | 651 | 29555535 |
Granulocytopenia | 19.09 | 14.24 | 21 | 18320 | 5973 | 29550213 |
Back pain | 18.18 | 14.24 | 22 | 18319 | 102262 | 29453924 |
Hypotension | 18.09 | 14.24 | 61 | 18280 | 194293 | 29361893 |
Colitis microscopic | 17.85 | 14.24 | 12 | 18329 | 1751 | 29554435 |
Malignant neoplasm progression | 17.76 | 14.24 | 12 | 18329 | 73847 | 29482339 |
Congenital scoliosis | 17.76 | 14.24 | 5 | 18336 | 81 | 29556105 |
Large granular lymphocytosis | 17.46 | 14.24 | 6 | 18335 | 192 | 29555994 |
Craniocerebral injury | 17.37 | 14.24 | 14 | 18327 | 2694 | 29553492 |
Anticonvulsant drug level increased | 17.34 | 14.24 | 11 | 18330 | 1455 | 29554731 |
Parasomnia | 17.18 | 14.24 | 7 | 18334 | 362 | 29555824 |
Suicide attempt | 16.86 | 14.24 | 53 | 18288 | 34057 | 29522129 |
Terminal insomnia | 16.43 | 14.24 | 7 | 18334 | 405 | 29555781 |
Cardiac failure | 16.39 | 14.24 | 15 | 18326 | 79272 | 29476914 |
Hand fracture | 16.35 | 14.24 | 11 | 18330 | 1606 | 29554580 |
Congenital knee deformity | 16.24 | 14.24 | 5 | 18336 | 112 | 29556074 |
Drug withdrawal syndrome | 16.20 | 14.24 | 35 | 18306 | 17949 | 29538237 |
Sleep deficit | 15.93 | 14.24 | 7 | 18334 | 437 | 29555749 |
Therapeutic response unexpected | 15.88 | 14.24 | 23 | 18318 | 8615 | 29547571 |
Interstitial lung disease | 15.83 | 14.24 | 8 | 18333 | 57710 | 29498476 |
Anger | 15.81 | 14.24 | 26 | 18315 | 10864 | 29545322 |
Dyskinesia | 15.78 | 14.24 | 37 | 18304 | 20024 | 29536162 |
Haemoglobin decreased | 15.63 | 14.24 | 27 | 18314 | 108348 | 29447838 |
Staring | 15.45 | 14.24 | 10 | 18331 | 1369 | 29554817 |
Head banging | 15.43 | 14.24 | 5 | 18336 | 133 | 29556053 |
General physical health deterioration | 15.41 | 14.24 | 25 | 18316 | 102832 | 29453354 |
Croup infectious | 15.31 | 14.24 | 6 | 18335 | 280 | 29555906 |
Congenital eyelid malformation | 15.02 | 14.24 | 4 | 18337 | 52 | 29556134 |
Lid lag | 15.01 | 14.24 | 3 | 18338 | 9 | 29556177 |
Bipolar disorder | 14.99 | 14.24 | 14 | 18327 | 3281 | 29552905 |
Encephalitis autoimmune | 14.82 | 14.24 | 7 | 18334 | 517 | 29555669 |
Confusional state | 14.64 | 14.24 | 132 | 18209 | 127745 | 29428441 |
Erythrosis | 14.62 | 14.24 | 4 | 18337 | 58 | 29556128 |
Mania | 14.40 | 14.24 | 22 | 18319 | 8641 | 29547545 |
Tardive dyskinesia | 14.34 | 14.24 | 17 | 18324 | 5241 | 29550945 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Seizure | 1294.67 | 12.40 | 908 | 33700 | 165984 | 64298140 |
Hyponatraemia | 707.77 | 12.40 | 606 | 34002 | 147733 | 64316391 |
Generalised tonic-clonic seizure | 264.49 | 12.40 | 198 | 34410 | 39659 | 64424465 |
Aggression | 240.60 | 12.40 | 199 | 34409 | 46033 | 64418091 |
Status epilepticus | 230.29 | 12.40 | 144 | 34464 | 21519 | 64442605 |
Epilepsy | 197.06 | 12.40 | 155 | 34453 | 33376 | 64430748 |
Completed suicide | 193.37 | 12.40 | 393 | 34215 | 224021 | 64240103 |
Somnolence | 189.09 | 12.40 | 368 | 34240 | 203277 | 64260847 |
Focal dyscognitive seizures | 171.22 | 12.40 | 65 | 34543 | 3225 | 64460899 |
Petit mal epilepsy | 163.90 | 12.40 | 71 | 34537 | 4961 | 64459163 |
Drug interaction | 156.99 | 12.40 | 488 | 34120 | 361595 | 64102529 |
Multiple-drug resistance | 146.49 | 12.40 | 71 | 34537 | 6431 | 64457693 |
Inappropriate antidiuretic hormone secretion | 146.18 | 12.40 | 110 | 34498 | 22179 | 64441945 |
Product substitution issue | 144.21 | 12.40 | 100 | 34508 | 17761 | 64446363 |
Partial seizures | 135.74 | 12.40 | 70 | 34538 | 7237 | 64456887 |
Psychogenic seizure | 135.55 | 12.40 | 47 | 34561 | 1794 | 64462330 |
Diplopia | 128.45 | 12.40 | 110 | 34498 | 26655 | 64437469 |
Nystagmus | 121.57 | 12.40 | 70 | 34538 | 8998 | 64455126 |
Sudden unexplained death in epilepsy | 118.79 | 12.40 | 33 | 34575 | 592 | 64463532 |
Stevens-Johnson syndrome | 112.57 | 12.40 | 114 | 34494 | 34135 | 64429989 |
Psychotic disorder | 106.24 | 12.40 | 111 | 34497 | 34467 | 64429657 |
Ataxia | 104.41 | 12.40 | 90 | 34518 | 21994 | 64442130 |
Hyperammonaemic encephalopathy | 102.68 | 12.40 | 48 | 34560 | 4010 | 64460114 |
Abnormal behaviour | 96.33 | 12.40 | 104 | 34504 | 33518 | 64430606 |
Myoclonic epilepsy | 84.50 | 12.40 | 32 | 34576 | 1576 | 64462548 |
Irritability | 80.56 | 12.40 | 99 | 34509 | 36647 | 64427477 |
Hypochloraemia | 80.19 | 12.40 | 33 | 34575 | 2028 | 64462096 |
Blood sodium decreased | 77.20 | 12.40 | 87 | 34521 | 29395 | 64434729 |
Suicidal ideation | 75.13 | 12.40 | 131 | 34477 | 66411 | 64397713 |
Agitation | 72.65 | 12.40 | 152 | 34456 | 88215 | 64375909 |
Suicide attempt | 71.50 | 12.40 | 133 | 34475 | 70874 | 64393250 |
Mitochondrial DNA mutation | 69.69 | 12.40 | 18 | 34590 | 241 | 64463883 |
Drug level decreased | 69.33 | 12.40 | 54 | 34554 | 11449 | 64452675 |
Electroencephalogram abnormal | 69.30 | 12.40 | 40 | 34568 | 5163 | 64458961 |
Balance disorder | 68.57 | 12.40 | 144 | 34464 | 83782 | 64380342 |
Infantile spasms | 68.11 | 12.40 | 18 | 34590 | 265 | 64463859 |
Febrile neutropenia | 67.72 | 12.40 | 10 | 34598 | 187647 | 64276477 |
Drug ineffective | 66.13 | 12.40 | 714 | 33894 | 839533 | 63624591 |
Pneumonia | 65.28 | 12.40 | 126 | 34482 | 559450 | 63904674 |
Memory impairment | 64.25 | 12.40 | 142 | 34466 | 85540 | 64378584 |
Dyspnoea | 60.98 | 12.40 | 191 | 34417 | 718483 | 63745641 |
Dizziness | 58.01 | 12.40 | 412 | 34196 | 429751 | 64034373 |
Drug reaction with eosinophilia and systemic symptoms | 57.66 | 12.40 | 104 | 34504 | 54113 | 64410011 |
Hypothermia | 56.13 | 12.40 | 61 | 34547 | 19795 | 64444329 |
Anaemia | 54.69 | 12.40 | 74 | 34534 | 378606 | 64085518 |
Anticonvulsant drug level decreased | 53.70 | 12.40 | 24 | 34584 | 1806 | 64462318 |
Acute kidney injury | 53.36 | 12.40 | 100 | 34508 | 449140 | 64014984 |
Propofol infusion syndrome | 53.26 | 12.40 | 23 | 34585 | 1594 | 64462530 |
Mania | 53.12 | 12.40 | 54 | 34554 | 16232 | 64447892 |
Arthralgia | 52.92 | 12.40 | 98 | 34510 | 442162 | 64021962 |
Neuroleptic malignant syndrome | 52.62 | 12.40 | 66 | 34542 | 24930 | 64439194 |
Diarrhoea | 51.95 | 12.40 | 206 | 34402 | 722498 | 63741626 |
Behaviour disorder | 50.80 | 12.40 | 31 | 34577 | 4431 | 64459693 |
Infusion related reaction | 50.43 | 12.40 | 13 | 34595 | 164454 | 64299670 |
Bipolar disorder | 50.26 | 12.40 | 36 | 34572 | 6725 | 64457399 |
Cognitive disorder | 47.89 | 12.40 | 97 | 34511 | 54990 | 64409134 |
Speech disorder | 47.83 | 12.40 | 90 | 34518 | 48351 | 64415773 |
Joint swelling | 46.58 | 12.40 | 29 | 34579 | 215353 | 64248771 |
Death | 45.43 | 12.40 | 122 | 34486 | 482583 | 63981541 |
Coma | 45.32 | 12.40 | 126 | 34482 | 87489 | 64376635 |
Dyskinesia | 45.03 | 12.40 | 78 | 34530 | 39310 | 64424814 |
Intentional self-injury | 44.89 | 12.40 | 66 | 34542 | 28978 | 64435146 |
Intentional overdose | 44.23 | 12.40 | 127 | 34481 | 89817 | 64374307 |
Intellectual disability | 42.13 | 12.40 | 17 | 34591 | 993 | 64463131 |
Simple partial seizures | 41.31 | 12.40 | 15 | 34593 | 656 | 64463468 |
Sopor | 41.01 | 12.40 | 64 | 34544 | 29597 | 64434527 |
Cross sensitivity reaction | 39.89 | 12.40 | 24 | 34584 | 3343 | 64460781 |
Blood gases abnormal | 39.13 | 12.40 | 16 | 34592 | 967 | 64463157 |
Sedation | 38.43 | 12.40 | 75 | 34533 | 41387 | 64422737 |
Drug withdrawal convulsions | 38.41 | 12.40 | 20 | 34588 | 2108 | 64462016 |
Depression | 36.96 | 12.40 | 195 | 34413 | 183096 | 64281028 |
Granulocytopenia | 36.59 | 12.40 | 36 | 34572 | 10404 | 64453720 |
Mental disorder | 36.48 | 12.40 | 57 | 34551 | 26388 | 64437736 |
Contraindicated product administered | 36.11 | 12.40 | 7 | 34601 | 107822 | 64356302 |
Gene mutation | 35.96 | 12.40 | 19 | 34589 | 2063 | 64462061 |
Peripheral swelling | 35.38 | 12.40 | 36 | 34572 | 209117 | 64255007 |
Gastric lavage | 35.28 | 12.40 | 8 | 34600 | 59 | 64464065 |
Psychomotor hyperactivity | 35.05 | 12.40 | 41 | 34567 | 14410 | 64449714 |
Thyroxine free decreased | 34.51 | 12.40 | 14 | 34594 | 829 | 64463295 |
Cough | 34.31 | 12.40 | 69 | 34539 | 302079 | 64162045 |
Sepsis | 34.24 | 12.40 | 44 | 34564 | 230297 | 64233827 |
Lower respiratory tract infection | 34.21 | 12.40 | 5 | 34603 | 94609 | 64369515 |
Seizure cluster | 33.54 | 12.40 | 11 | 34597 | 353 | 64463771 |
Drug withdrawal syndrome | 33.23 | 12.40 | 60 | 34548 | 31231 | 64432893 |
Toxicity to various agents | 32.71 | 12.40 | 318 | 34290 | 363195 | 64100929 |
Dissociation | 31.94 | 12.40 | 20 | 34588 | 2991 | 64461133 |
Catatonia | 31.91 | 12.40 | 29 | 34579 | 7591 | 64456533 |
Anticonvulsant drug level above therapeutic | 31.80 | 12.40 | 14 | 34594 | 1016 | 64463108 |
Rheumatoid arthritis | 31.71 | 12.40 | 25 | 34583 | 164269 | 64299855 |
General physical health deterioration | 31.48 | 12.40 | 38 | 34570 | 204387 | 64259737 |
Swelling | 31.40 | 12.40 | 24 | 34584 | 160194 | 64303930 |
Trigeminal neuralgia | 31.35 | 12.40 | 20 | 34588 | 3089 | 64461035 |
Paradoxical drug reaction | 31.09 | 12.40 | 26 | 34582 | 6094 | 64458030 |
Brain malformation | 30.82 | 12.40 | 7 | 34601 | 52 | 64464072 |
Disturbance in attention | 30.69 | 12.40 | 68 | 34540 | 41006 | 64423118 |
Anger | 30.67 | 12.40 | 40 | 34568 | 15701 | 64448423 |
Partial seizures with secondary generalisation | 30.29 | 12.40 | 11 | 34597 | 481 | 64463643 |
Lennox-Gastaut syndrome | 30.04 | 12.40 | 9 | 34599 | 213 | 64463911 |
Hallucination, auditory | 29.87 | 12.40 | 41 | 34567 | 16898 | 64447226 |
Cardiac failure | 29.76 | 12.40 | 17 | 34591 | 132356 | 64331768 |
Aphasia | 29.75 | 12.40 | 67 | 34541 | 40839 | 64423285 |
Arthropathy | 29.47 | 12.40 | 14 | 34594 | 120953 | 64343171 |
Educational problem | 28.53 | 12.40 | 10 | 34598 | 394 | 64463730 |
Oedema peripheral | 28.43 | 12.40 | 43 | 34565 | 210274 | 64253850 |
Respiratory arrest | 28.18 | 12.40 | 77 | 34531 | 52908 | 64411216 |
Tremor | 28.04 | 12.40 | 155 | 34453 | 148075 | 64316049 |
Wrong patient received product | 27.89 | 12.40 | 20 | 34588 | 3742 | 64460382 |
Gait disturbance | 27.39 | 12.40 | 172 | 34436 | 171983 | 64292141 |
Tardive dyskinesia | 27.35 | 12.40 | 29 | 34579 | 9149 | 64454975 |
Drug resistance | 27.23 | 12.40 | 59 | 34549 | 35043 | 64429081 |
Atrial fibrillation | 27.20 | 12.40 | 31 | 34577 | 171058 | 64293066 |
Pain | 27.06 | 12.40 | 180 | 34428 | 553331 | 63910793 |
Impulsive behaviour | 26.53 | 12.40 | 17 | 34591 | 2646 | 64461478 |
Blood osmolarity decreased | 26.53 | 12.40 | 13 | 34595 | 1205 | 64462919 |
Encephalitis autoimmune | 26.47 | 12.40 | 15 | 34593 | 1869 | 64462255 |
Brown tumour | 26.25 | 12.40 | 6 | 34602 | 46 | 64464078 |
Malignant neoplasm progression | 26.09 | 12.40 | 14 | 34594 | 112857 | 64351267 |
Poisoning | 25.89 | 12.40 | 44 | 34564 | 21835 | 64442289 |
Dysmorphism | 25.70 | 12.40 | 10 | 34598 | 530 | 64463594 |
Parkinsonism | 25.66 | 12.40 | 35 | 34573 | 14338 | 64449786 |
Bradykinesia | 25.60 | 12.40 | 24 | 34584 | 6536 | 64457588 |
Therapeutic product ineffective for unapproved indication | 25.44 | 12.40 | 7 | 34601 | 121 | 64464003 |
Psychomotor skills impaired | 25.25 | 12.40 | 19 | 34589 | 3826 | 64460298 |
Back pain | 25.20 | 12.40 | 61 | 34547 | 250110 | 64214014 |
Drug level increased | 24.85 | 12.40 | 56 | 34552 | 34140 | 64429984 |
Strabismus | 24.72 | 12.40 | 15 | 34593 | 2122 | 64462002 |
Bipolar I disorder | 24.61 | 12.40 | 14 | 34594 | 1757 | 64462367 |
Glossodynia | 24.38 | 12.40 | 3 | 34605 | 64693 | 64399431 |
Aura | 24.35 | 12.40 | 11 | 34597 | 849 | 64463275 |
Autonomic nervous system imbalance | 24.04 | 12.40 | 19 | 34589 | 4113 | 64460011 |
Irregular sleep phase | 23.91 | 12.40 | 6 | 34602 | 71 | 64464053 |
Infection | 23.84 | 12.40 | 39 | 34569 | 184841 | 64279283 |
Tonic convulsion | 23.83 | 12.40 | 14 | 34594 | 1867 | 64462257 |
Nasopharyngitis | 23.79 | 12.40 | 43 | 34565 | 196030 | 64268094 |
Drug ineffective for unapproved indication | 23.77 | 12.40 | 52 | 34556 | 31081 | 64433043 |
Multiple sclerosis | 23.62 | 12.40 | 39 | 34569 | 18902 | 64445222 |
Blood creatine phosphokinase increased | 23.47 | 12.40 | 77 | 34531 | 58481 | 64405643 |
Pericarditis | 23.32 | 12.40 | 3 | 34605 | 62513 | 64401611 |
Change in seizure presentation | 23.23 | 12.40 | 8 | 34600 | 299 | 64463825 |
Terminal insomnia | 23.15 | 12.40 | 11 | 34597 | 953 | 64463171 |
Staring | 23.06 | 12.40 | 15 | 34593 | 2395 | 64461729 |
Parasomnia | 22.97 | 12.40 | 9 | 34599 | 486 | 64463638 |
Abortion spontaneous | 22.71 | 12.40 | 45 | 34563 | 25098 | 64439026 |
Cardiac failure congestive | 22.61 | 12.40 | 22 | 34586 | 130558 | 64333566 |
Anticonvulsant drug level below therapeutic | 22.52 | 12.40 | 11 | 34597 | 1013 | 64463111 |
Malaise | 22.41 | 12.40 | 123 | 34485 | 396124 | 64068000 |
Gaze palsy | 22.29 | 12.40 | 15 | 34593 | 2535 | 64461589 |
Paranoia | 22.21 | 12.40 | 35 | 34573 | 16317 | 64447807 |
Hyperammonaemia | 22.21 | 12.40 | 27 | 34581 | 9877 | 64454247 |
Learning disorder | 22.12 | 12.40 | 9 | 34599 | 537 | 64463587 |
Overdose | 22.09 | 12.40 | 154 | 34454 | 159412 | 64304712 |
Electrocardiogram QRS complex prolonged | 22.04 | 12.40 | 26 | 34582 | 9218 | 64454906 |
Speech disorder developmental | 21.91 | 12.40 | 9 | 34599 | 550 | 64463574 |
Affective disorder | 21.79 | 12.40 | 22 | 34586 | 6558 | 64457566 |
Craniocerebral injury | 21.75 | 12.40 | 18 | 34590 | 4158 | 64459966 |
Therapeutic product effective for unapproved indication | 21.68 | 12.40 | 6 | 34602 | 106 | 64464018 |
Colitis ischaemic | 21.47 | 12.40 | 31 | 34577 | 13383 | 64450741 |
Coma blister | 21.21 | 12.40 | 7 | 34601 | 229 | 64463895 |
Neurotoxicity | 21.18 | 12.40 | 46 | 34562 | 27358 | 64436766 |
Herpes zoster | 21.15 | 12.40 | 8 | 34600 | 79179 | 64384945 |
Hypotonia | 21.08 | 12.40 | 28 | 34580 | 11184 | 64452940 |
Dysarthria | 21.08 | 12.40 | 75 | 34533 | 59331 | 64404793 |
Stomatitis | 20.74 | 12.40 | 17 | 34591 | 109588 | 64354536 |
Pain in extremity | 20.67 | 12.40 | 88 | 34520 | 302997 | 64161127 |
Idiopathic generalised epilepsy | 20.51 | 12.40 | 5 | 34603 | 52 | 64464072 |
Dyspnoea exertional | 20.45 | 12.40 | 7 | 34601 | 73723 | 64390401 |
Coordination abnormal | 20.28 | 12.40 | 32 | 34576 | 14932 | 64449192 |
Exposure during pregnancy | 20.23 | 12.40 | 89 | 34519 | 77586 | 64386538 |
Unmasking of previously unidentified disease | 20.19 | 12.40 | 12 | 34596 | 1635 | 64462489 |
Screaming | 20.04 | 12.40 | 16 | 34592 | 3513 | 64460611 |
Gastrointestinal haemorrhage | 19.93 | 12.40 | 25 | 34583 | 132287 | 64331837 |
Postictal psychosis | 19.72 | 12.40 | 6 | 34602 | 150 | 64463974 |
Delusion | 19.71 | 12.40 | 35 | 34573 | 17979 | 64446145 |
Muscle twitching | 19.63 | 12.40 | 36 | 34572 | 18962 | 64445162 |
Blood antidiuretic hormone decreased | 19.59 | 12.40 | 3 | 34605 | 0 | 64464124 |
Tic | 19.59 | 12.40 | 14 | 34594 | 2605 | 64461519 |
Lethargy | 19.54 | 12.40 | 84 | 34524 | 72510 | 64391614 |
Hallucination | 19.41 | 12.40 | 84 | 34524 | 72704 | 64391420 |
Depressed mood | 19.27 | 12.40 | 57 | 34551 | 40955 | 64423169 |
Loss of consciousness | 19.27 | 12.40 | 141 | 34467 | 148224 | 64315900 |
Dysphoria | 18.97 | 12.40 | 17 | 34591 | 4371 | 64459753 |
Agranulocytosis | 18.80 | 12.40 | 54 | 34554 | 38175 | 64425949 |
Sleep paralysis | 18.58 | 12.40 | 8 | 34600 | 550 | 64463574 |
Haemoglobin decreased | 18.52 | 12.40 | 49 | 34559 | 195014 | 64269110 |
Arthritis | 18.50 | 12.40 | 11 | 34597 | 83803 | 64380321 |
Anticonvulsant drug level increased | 18.46 | 12.40 | 13 | 34595 | 2364 | 64461760 |
Weight increased | 18.35 | 12.40 | 185 | 34423 | 213163 | 64250961 |
Fear | 18.10 | 12.40 | 36 | 34572 | 20135 | 64443989 |
Myocardial infarction | 17.84 | 12.40 | 39 | 34569 | 165782 | 64298342 |
Alopecia | 17.80 | 12.40 | 39 | 34569 | 165651 | 64298473 |
Product colour issue | 17.62 | 12.40 | 8 | 34600 | 625 | 64463499 |
Mood altered | 17.43 | 12.40 | 31 | 34577 | 15948 | 64448176 |
Nausea | 17.42 | 12.40 | 307 | 34301 | 785493 | 63678631 |
Dystonia | 17.33 | 12.40 | 34 | 34574 | 18831 | 64445293 |
Atonic seizures | 17.24 | 12.40 | 8 | 34600 | 657 | 64463467 |
Condition aggravated | 17.20 | 12.40 | 288 | 34320 | 372138 | 64091986 |
Normal newborn | 17.19 | 12.40 | 18 | 34590 | 5599 | 64458525 |
Eye movement disorder | 17.03 | 12.40 | 20 | 34588 | 7059 | 64457065 |
Renal failure | 16.98 | 12.40 | 46 | 34562 | 181642 | 64282482 |
Nervousness | 16.77 | 12.40 | 44 | 34564 | 29512 | 64434612 |
Head injury | 16.74 | 12.40 | 47 | 34561 | 32795 | 64431329 |
Cardio-respiratory arrest | 16.70 | 12.40 | 100 | 34508 | 98293 | 64365831 |
Enuresis | 16.60 | 12.40 | 13 | 34595 | 2777 | 64461347 |
Epistaxis | 16.45 | 12.40 | 17 | 34591 | 98114 | 64366010 |
Confusional state | 16.40 | 12.40 | 213 | 34395 | 260931 | 64203193 |
Developmental coordination disorder | 16.30 | 12.40 | 3 | 34605 | 6 | 64464118 |
Rasmussen encephalitis | 16.30 | 12.40 | 3 | 34605 | 6 | 64464118 |
Electrocardiogram repolarisation abnormality | 16.28 | 12.40 | 11 | 34597 | 1871 | 64462253 |
Musculoskeletal pain | 16.15 | 12.40 | 12 | 34596 | 81282 | 64382842 |
Anxiety | 16.13 | 12.40 | 173 | 34435 | 202476 | 64261648 |
Logorrhoea | 16.13 | 12.40 | 15 | 34593 | 4044 | 64460080 |
Disorientation | 16.11 | 12.40 | 66 | 34542 | 55762 | 64408362 |
Renal impairment | 16.02 | 12.40 | 30 | 34578 | 134987 | 64329137 |
Atrioventricular block first degree | 16.02 | 12.40 | 24 | 34584 | 10710 | 64453414 |
Hippocampal sclerosis | 15.96 | 12.40 | 5 | 34603 | 138 | 64463986 |
Macule | 15.96 | 12.40 | 12 | 34596 | 2414 | 64461710 |
Restlessness | 15.66 | 12.40 | 52 | 34556 | 39733 | 64424391 |
Productive cough | 15.61 | 12.40 | 10 | 34598 | 73193 | 64390931 |
Intestinal intraepithelial lymphocytes increased | 15.44 | 12.40 | 3 | 34605 | 9 | 64464115 |
Asthma | 15.40 | 12.40 | 17 | 34591 | 95208 | 64368916 |
Gamma-glutamyltransferase increased | 15.33 | 12.40 | 59 | 34549 | 48451 | 64415673 |
Extensor plantar response | 15.19 | 12.40 | 10 | 34598 | 1630 | 64462494 |
Drug screen positive | 15.15 | 12.40 | 17 | 34591 | 5712 | 64458412 |
Lactic acidosis | 15.12 | 12.40 | 7 | 34601 | 61403 | 64402721 |
Postictal state | 15.11 | 12.40 | 10 | 34598 | 1643 | 64462481 |
Large granular lymphocytosis | 14.99 | 12.40 | 6 | 34602 | 343 | 64463781 |
Neuropathy peripheral | 14.95 | 12.40 | 25 | 34583 | 117500 | 64346624 |
Impaired healing | 14.72 | 12.40 | 7 | 34601 | 60466 | 64403658 |
Abnormal sensation in eye | 14.72 | 12.40 | 10 | 34598 | 1717 | 64462407 |
Crying | 14.71 | 12.40 | 33 | 34575 | 20057 | 64444067 |
Rash maculo-papular | 14.70 | 12.40 | 57 | 34551 | 46969 | 64417155 |
Blood chloride decreased | 14.69 | 12.40 | 19 | 34589 | 7397 | 64456727 |
Hypersensitivity | 14.67 | 12.40 | 55 | 34553 | 196397 | 64267727 |
Antipsychotic drug level decreased | 14.58 | 12.40 | 8 | 34600 | 936 | 64463188 |
Nasal congestion | 14.38 | 12.40 | 7 | 34601 | 59651 | 64404473 |
Mental status changes | 14.38 | 12.40 | 68 | 34540 | 61094 | 64403030 |
Pancytopenia | 14.37 | 12.40 | 35 | 34573 | 143274 | 64320850 |
Fever neonatal | 14.23 | 12.40 | 3 | 34605 | 15 | 64464109 |
Libido decreased | 14.05 | 12.40 | 15 | 34593 | 4769 | 64459355 |
Drop attacks | 14.04 | 12.40 | 8 | 34600 | 1007 | 64463117 |
Ammonia increased | 14.01 | 12.40 | 18 | 34590 | 6959 | 64457165 |
Fall | 13.68 | 12.40 | 306 | 34302 | 416520 | 64047604 |
Therapeutic response unexpected | 13.67 | 12.40 | 29 | 34579 | 16972 | 64447152 |
Social fear | 13.63 | 12.40 | 3 | 34605 | 19 | 64464105 |
Discomfort | 13.57 | 12.40 | 14 | 34594 | 80864 | 64383260 |
Systemic lupus erythematosus | 13.52 | 12.40 | 13 | 34595 | 77599 | 64386525 |
Multiple organ dysfunction syndrome | 13.44 | 12.40 | 21 | 34587 | 101392 | 64362732 |
Melaena | 13.34 | 12.40 | 6 | 34602 | 53542 | 64410582 |
Poisoning deliberate | 13.27 | 12.40 | 25 | 34583 | 13433 | 64450691 |
Erectile dysfunction | 13.13 | 12.40 | 24 | 34584 | 12603 | 64451521 |
Follicular mucinosis | 13.01 | 12.40 | 3 | 34605 | 24 | 64464100 |
Leukopenia | 13.01 | 12.40 | 96 | 34512 | 101146 | 64362978 |
Immunodeficiency common variable | 12.83 | 12.40 | 5 | 34603 | 266 | 64463858 |
Head banging | 12.78 | 12.40 | 6 | 34602 | 506 | 64463618 |
Mucosal inflammation | 12.74 | 12.40 | 9 | 34599 | 62575 | 64401549 |
Blood pressure fluctuation | 12.63 | 12.40 | 6 | 34602 | 51865 | 64412259 |
Otitis media | 12.53 | 12.40 | 15 | 34593 | 5398 | 64458726 |
Apathy | 12.52 | 12.40 | 22 | 34586 | 11210 | 64452914 |
Ascites | 12.51 | 12.40 | 9 | 34599 | 61992 | 64402132 |
Platelet count decreased | 12.49 | 12.40 | 47 | 34561 | 167664 | 64296460 |
None
Source | Code | Description |
---|---|---|
ATC | N03AF02 | NERVOUS SYSTEM ANTIEPILEPTICS ANTIEPILEPTICS Carboxamide derivatives |
FDA PE | N0000008486 | Decreased Central Nervous System Disorganized Electrical Activity |
MeSH PA | D000927 | Anticonvulsants |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D065701 | Cytochrome P-450 CYP3A Inducers |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D065606 | Metabolic Side Effects of Drugs and Substances |
MeSH PA | D026941 | Sodium Channel Blockers |
MeSH PA | D061567 | Voltage-Gated Sodium Channel Blockers |
CHEBI has role | CHEBI:35623 | anticonvulsants |
CHEBI has role | CHEBI:88188 | allergenic drug |
FDA EPC | N0000175753 | Anti-epileptic Agent |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Localization-related epilepsy | indication | 230381009 | DOID:2234 |
Epilepsy characterized by intractable complex partial seizures | indication | 442481002 | |
Simple partial seizure | indication | 117891000119100 | |
Suicidal thoughts | contraindication | 6471006 | |
Mood swings | contraindication | 18963009 | |
Depressive disorder | contraindication | 35489007 | |
Syndrome of inappropriate vasopressin secretion | contraindication | 55004003 | DOID:3401 |
Acute nephropathy | contraindication | 58574008 | |
Hyponatremia | contraindication | 89627008 | |
Impaired renal function disorder | contraindication | 197663003 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 12.9 | acidic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
150MG | OXTELLAR XR | SUPERNUS PHARMS | N202810 | Oct. 19, 2012 | RX | TABLET, EXTENDED RELEASE | ORAL | 10220042 | April 13, 2027 | TREATMENT OF PARTIAL-ONSET SEIZURES |
150MG | OXTELLAR XR | SUPERNUS PHARMS | N202810 | Oct. 19, 2012 | RX | TABLET, EXTENDED RELEASE | ORAL | 7910131 | April 13, 2027 | TREATMENT OF PARTIAL-ONSET SEIZURES |
150MG | OXTELLAR XR | SUPERNUS PHARMS | N202810 | Oct. 19, 2012 | RX | TABLET, EXTENDED RELEASE | ORAL | 9119791 | April 13, 2027 | TREATMENT OF PARTIAL-ONSET SEIZURES |
300MG | OXTELLAR XR | SUPERNUS PHARMS | N202810 | Oct. 19, 2012 | RX | TABLET, EXTENDED RELEASE | ORAL | 10220042 | April 13, 2027 | TREATMENT OF PARTIAL-ONSET SEIZURES |
300MG | OXTELLAR XR | SUPERNUS PHARMS | N202810 | Oct. 19, 2012 | RX | TABLET, EXTENDED RELEASE | ORAL | 7910131 | April 13, 2027 | TREATMENT OF PARTIAL-ONSET SEIZURES |
300MG | OXTELLAR XR | SUPERNUS PHARMS | N202810 | Oct. 19, 2012 | RX | TABLET, EXTENDED RELEASE | ORAL | 9119791 | April 13, 2027 | TREATMENT OF PARTIAL-ONSET SEIZURES |
600MG | OXTELLAR XR | SUPERNUS PHARMS | N202810 | Oct. 19, 2012 | RX | TABLET, EXTENDED RELEASE | ORAL | 10220042 | April 13, 2027 | TREATMENT OF PARTIAL-ONSET SEIZURES |
600MG | OXTELLAR XR | SUPERNUS PHARMS | N202810 | Oct. 19, 2012 | RX | TABLET, EXTENDED RELEASE | ORAL | 7910131 | April 13, 2027 | TREATMENT OF PARTIAL-ONSET SEIZURES |
600MG | OXTELLAR XR | SUPERNUS PHARMS | N202810 | Oct. 19, 2012 | RX | TABLET, EXTENDED RELEASE | ORAL | 9119791 | April 13, 2027 | TREATMENT OF PARTIAL-ONSET SEIZURES |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium channel protein type 5 subunit alpha | Ion channel | BLOCKER | WOMBAT-PK | CHEMBL |
ID | Source |
---|---|
4021196 | VUID |
N0000148642 | NUI |
D00533 | KEGG_DRUG |
4021196 | VANDF |
C0069751 | UMLSCUI |
CHEBI:7824 | CHEBI |
CHEMBL1068 | ChEMBL_ID |
DB00776 | DRUGBANK_ID |
D000078330 | MESH_DESCRIPTOR_UI |
34312 | PUBCHEM_CID |
7254 | IUPHAR_LIGAND_ID |
4585 | INN_ID |
VZI5B1W380 | UNII |
32624 | RXNORM |
121517 | MMSL |
8631 | MMSL |
d04513 | MMSL |
006035 | NDDF |
116511002 | SNOMEDCT_US |
387025007 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Oxcarbazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0199 | SUSPENSION | 300 mg | ORAL | ANDA | 30 sections |
Trileptal | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0337 | TABLET, FILM COATED | 300 mg | ORAL | NDA | 33 sections |
Trileptal | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0357 | SUSPENSION | 60 mg | ORAL | NDA | 33 sections |
Trileptal | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0456 | TABLET, FILM COATED | 150 mg | ORAL | NDA | 33 sections |
Trileptal | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0457 | TABLET, FILM COATED | 600 mg | ORAL | NDA | 33 sections |
Oxcarbazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8153 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 30 sections |
Oxcarbazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8292 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 30 sections |
Oxcarbazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-6270 | SUSPENSION | 60 mg | ORAL | NDA authorized generic | 31 sections |
OXTELLAR XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17772-121 | TABLET | 150 mg | ORAL | NDA | 34 sections |
OXTELLAR XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17772-121 | TABLET | 150 mg | ORAL | NDA | 34 sections |
OXTELLAR XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17772-122 | TABLET | 300 mg | ORAL | NDA | 34 sections |
OXTELLAR XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17772-122 | TABLET | 300 mg | ORAL | NDA | 34 sections |
OXTELLAR XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17772-123 | TABLET | 600 mg | ORAL | NDA | 34 sections |
OXTELLAR XR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17772-123 | TABLET | 600 mg | ORAL | NDA | 34 sections |
Oxcarbazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-862 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 30 sections |
Oxcarbazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-863 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 30 sections |
Oxcarbazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-864 | TABLET, FILM COATED | 600 mg | ORAL | ANDA | 30 sections |
Oxcarbazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 31722-023 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 28 sections |
Oxcarbazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 31722-024 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 28 sections |
Oxcarbazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 31722-025 | TABLET, FILM COATED | 600 mg | ORAL | ANDA | 28 sections |
Oxcarbazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-684 | TABLET, FILM COATED | 150 mg | ORAL | ANDA | 29 sections |
Oxcarbazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-841 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 29 sections |
Oxcarbazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-842 | TABLET, FILM COATED | 600 mg | ORAL | ANDA | 29 sections |
OXCARBAZEPINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-5003 | TABLET, FILM COATED | 300 mg | ORAL | ANDA | 32 sections |
Oxcarbazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50268-649 | SUSPENSION | 300 mg | ORAL | ANDA | 19 sections |
Oxcarbazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50383-312 | SUSPENSION | 300 mg | ORAL | ANDA | 29 sections |
Oxcarbazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50383-312 | SUSPENSION | 300 mg | ORAL | ANDA | 29 sections |
Oxcarbazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-4105 | TABLET | 150 mg | ORAL | ANDA | 35 sections |
Oxcarbazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-4106 | TABLET | 300 mg | ORAL | ANDA | 35 sections |
Oxcarbazepine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-4107 | TABLET | 600 mg | ORAL | ANDA | 35 sections |