oxazepam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
diazepam derivatives	2015	604-75-1

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: oxazepam droxacepam durazepam noctazepam tazepam zaxopam	A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia. Molecular weight: 286.72 Formula: C15H11ClN2O2 CLOGP: 2.31 LIPINSKI: 0 HAC: 4 HDO: 2 TPSA: 61.69 ALOGS: -3.51 ROTB: 1 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

oxazepam
droxacepam
durazepam
noctazepam
tazepam
zaxopam

A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia.

Molecular weight: 286.72
Formula: C15H11ClN2O2
CLOGP: 2.31
LIPINSKI: 0
HAC: 4
HDO: 2
TPSA: 61.69
ALOGS: -3.51
ROTB: 1

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
50	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.05 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0.50 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	6.98 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	97 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.59 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	1.10 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.04 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	6.70 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
June 4, 1965	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	1073.58	13.76	982	32674	211517	50359951
Depressed level of consciousness	788.96	13.76	468	33188	51485	50519983
Intentional overdose	778.34	13.76	496	33160	62008	50509460
Coma	714.62	13.76	454	33202	56425	50515043
Orthostatic hypotension	677.06	13.76	349	33307	29132	50542336
Sedation	619.44	13.76	333	33323	30277	50541191
Sedation complication	610.82	13.76	227	33429	8539	50562929
Creatinine renal clearance decreased	560.73	13.76	232	33424	11649	50559819
Poisoning deliberate	537.03	13.76	201	33455	7711	50563757
Cognitive disorder	526.19	13.76	341	33315	43782	50527686
Intentional self-injury	525.89	13.76	272	33384	22840	50548628
Fall	455.80	13.76	804	32852	334128	50237340
Blood calcium decreased	437.69	13.76	232	33424	20474	50550994
Hypotension	377.76	13.76	609	33047	234860	50336608
Somnolence	360.50	13.76	478	33178	154507	50416961
Balance disorder	357.75	13.76	328	33328	70262	50501206
Suicide attempt	313.25	13.76	266	33390	51466	50520002
Hyponatraemia	266.74	13.76	324	33332	95815	50475653
Mobility decreased	232.45	13.76	276	33380	79672	50491796
Drug abuse	217.33	13.76	232	33424	59614	50511854
Drug ineffective	203.76	13.76	150	33506	819183	49752285
Overdose	190.27	13.76	280	33376	99447	50472021
Constipation	180.70	13.76	388	33268	185320	50386148
Electrocardiogram QT prolonged	177.60	13.76	195	33461	51691	50519777
Drug dependence	160.94	13.76	121	33535	19638	50551830
Miosis	145.51	13.76	75	33581	6235	50565233
Drug interaction	134.67	13.76	362	33294	199259	50372209
Bradycardia	131.69	13.76	187	33469	64239	50507229
Hepatocellular injury	130.13	13.76	120	33536	25827	50545641
Asphyxia	126.57	13.76	65	33591	5362	50566106
Confusional state	122.19	13.76	334	33322	185594	50385874
Prescription form tampering	119.39	13.76	34	33622	534	50570934
Rash	108.33	13.76	80	33576	437391	50134077
Cholestasis	105.68	13.76	106	33550	25295	50546173
Rhabdomyolysis	102.35	13.76	128	33528	38899	50532569
Pneumonia aspiration	101.68	13.76	114	33542	30890	50540578
Drug hypersensitivity	100.67	13.76	22	33634	250988	50320480
Abdominal discomfort	97.69	13.76	18	33638	231623	50339845
Product dose omission issue	89.98	13.76	9	33647	183829	50387639
Hypothermia	87.79	13.76	69	33587	11947	50559521
Inappropriate antidiuretic hormone secretion	86.52	13.76	71	33585	13072	50558396
Drug intolerance	86.24	13.76	20	33636	219084	50352384
Respiratory depression	83.54	13.76	67	33589	11943	50559525
Arthralgia	82.05	13.76	103	33553	438599	50132869
Rheumatoid arthritis	78.70	13.76	19	33637	202531	50368937
Peripheral swelling	78.69	13.76	20	33636	205916	50365552
Joint swelling	77.65	13.76	33	33623	245253	50326215
Swelling	75.81	13.76	20	33636	200852	50370616
Sinusitis	74.63	13.76	12	33644	170546	50400922
Lactic acidosis	72.86	13.76	100	33556	33255	50538213
Hallucination, visual	72.30	13.76	71	33585	16511	50554957
Aggression	71.56	13.76	79	33577	21037	50550431
Arthropathy	69.33	13.76	11	33645	157895	50413573
Hypokalaemia	68.93	13.76	169	33487	87823	50483645
Hypersensitivity	68.00	13.76	29	33627	215132	50356336
Bladder dilatation	64.80	13.76	23	33633	755	50570713
Wrong patient received product	63.01	13.76	28	33628	1672	50569796
Glossodynia	61.12	13.76	4	33652	115565	50455903
Headache	58.97	13.76	159	33497	506376	50065092
Acute kidney injury	57.31	13.76	301	33355	227757	50343711
Altered state of consciousness	56.06	13.76	71	33585	21839	50549629
Contraindicated product administered	55.86	13.76	15	33641	148943	50422525
Bradypnoea	55.34	13.76	31	33625	3043	50568425
Loss of consciousness	53.66	13.76	172	33484	104181	50467287
Hyperthermia	53.66	13.76	43	33613	7653	50563815
Akathisia	53.21	13.76	44	33612	8185	50563283
Reduced facial expression	51.94	13.76	24	33632	1570	50569898
Alopecia	51.76	13.76	52	33604	244995	50326473
Intentional product misuse	51.57	13.76	103	33553	46631	50524837
Therapeutic product effect decreased	50.45	13.76	14	33642	136036	50435432
Injection site pain	50.41	13.76	7	33649	111017	50460451
Victim of sexual abuse	49.53	13.76	17	33639	504	50570964
Fatigue	49.53	13.76	273	33383	707328	49864140
Urinary retention	49.07	13.76	73	33583	26117	50545351
Infusion related reaction	48.73	13.76	26	33630	169531	50401937
Infection	47.58	13.76	28	33628	172926	50398542
Benzodiazepine drug level increased	47.57	13.76	13	33643	174	50571294
Wound	47.27	13.76	7	33649	105787	50465681
Back pain	47.25	13.76	46	33610	219984	50351484
Poisoning	46.49	13.76	49	33607	12380	50559088
Disturbance in attention	46.11	13.76	78	33578	31108	50540360
Lower respiratory tract infection	45.67	13.76	5	33651	95196	50476272
Restlessness	45.50	13.76	69	33587	25104	50546364
Drug use disorder	44.75	13.76	27	33629	3045	50568423
Agitation	43.35	13.76	104	33552	53280	50518188
Listless	42.75	13.76	24	33632	2366	50569102
Respiratory acidosis	42.71	13.76	34	33622	5994	50565474
Oxygen saturation decreased	42.54	13.76	126	33530	73122	50498346
Neuroleptic malignant syndrome	41.85	13.76	44	33612	11086	50560382
Hand deformity	41.73	13.76	8	33648	100191	50471277
Mydriasis	41.73	13.76	43	33613	10584	50560884
Faecal vomiting	40.37	13.76	15	33641	562	50570906
Haemodynamic instability	40.00	13.76	37	33619	7987	50563481
Apathy	39.96	13.76	36	33620	7512	50563956
Patient uncooperative	39.86	13.76	11	33645	153	50571315
Extrapyramidal disorder	39.81	13.76	44	33612	11726	50559742
Delirium	39.55	13.76	82	33574	38110	50533358
Nasopharyngitis	39.52	13.76	42	33614	192885	50378583
Tachycardia	37.99	13.76	149	33507	99614	50471854
Cough	37.77	13.76	64	33592	241200	50330268
Cardiac failure congestive	36.74	13.76	6	33650	84376	50487092
Hypocoagulable state	36.57	13.76	16	33640	920	50570548
Stomatitis	36.51	13.76	11	33645	101333	50470135
Pain in extremity	36.10	13.76	80	33576	272785	50298683
Epilepsy	36.02	13.76	57	33599	21510	50549958
Suicidal ideation	35.77	13.76	99	33557	55286	50516182
Prescription drug used without a prescription	35.75	13.76	19	33637	1681	50569787
Disorientation	35.36	13.76	75	33581	35409	50536059
Pneumonia	35.35	13.76	131	33525	378270	50193198
Blister	35.19	13.76	7	33649	85411	50486057
Encephalopathy	34.46	13.76	72	33584	33639	50537829
Hypoventilation	34.13	13.76	25	33631	3896	50567572
Muscle rigidity	33.69	13.76	37	33619	9792	50561676
Housebound	32.13	13.76	10	33646	216	50571252
Drug level above therapeutic	31.89	13.76	24	33632	3896	50567572
Serotonin syndrome	31.60	13.76	58	33598	24655	50546813
Wrong patient	31.22	13.76	8	33648	82	50571386
Eosinophilia	30.74	13.76	49	33607	18603	50552865
Off label use	30.42	13.76	188	33468	474238	50097230
Hypereosinophilic syndrome	30.42	13.76	10	33646	259	50571209
Accidental overdose	30.40	13.76	50	33606	19483	50551985
Hypotonia	30.30	13.76	32	33624	8102	50563366
Potentiating drug interaction	30.24	13.76	23	33633	3793	50567675
Parkinsonism	29.80	13.76	33	33623	8814	50562654
Prothrombin time ratio decreased	29.79	13.76	11	33645	405	50571063
Hepatitis	29.64	13.76	65	33591	31388	50540080
Pericarditis	29.34	13.76	8	33648	78681	50492787
Hepatic infiltration eosinophilic	28.89	13.76	6	33650	21	50571447
Abnormal behaviour	28.83	13.76	49	33607	19609	50551859
Respiratory alkalosis	28.82	13.76	19	33637	2500	50568968
Hallucination	28.75	13.76	82	33574	46575	50524893
Blood thyroid stimulating hormone normal	28.75	13.76	8	33648	115	50571353
Drug withdrawal convulsions	28.11	13.76	15	33641	1338	50570130
Hypoventilation neonatal	28.06	13.76	6	33650	25	50571443
Wheezing	27.95	13.76	4	33652	62043	50509425
Neurological examination abnormal	27.79	13.76	9	33647	222	50571246
On and off phenomenon	27.51	13.76	15	33641	1397	50570071
Injection site erythema	27.23	13.76	8	33648	74928	50496540
Psychomotor skills impaired	27.16	13.76	17	33639	2047	50569421
White blood cell count decreased	26.70	13.76	23	33633	116699	50454769
Substance abuse	26.55	13.76	22	33634	4102	50567366
Pyrexia	26.30	13.76	147	33509	380056	50191412
Hallucination, synaesthetic	25.70	13.76	6	33650	40	50571428
Hyperkalaemia	25.36	13.76	80	33576	48009	50523459
Foreign body	25.35	13.76	16	33640	1955	50569513
Antisocial behaviour	25.25	13.76	9	33647	299	50571169
Behaviour disorder	24.94	13.76	17	33639	2363	50569105
Dyspnoea	24.76	13.76	239	33417	547369	50024099
Neuropathy peripheral	24.75	13.76	17	33639	96740	50474728
Withdrawal syndrome	24.69	13.76	43	33613	17547	50553921
Wrong rate	24.53	13.76	6	33650	50	50571418
Disease progression	24.32	13.76	17	33639	95849	50475619
Neurosensory hypoacusis	23.91	13.76	8	33648	219	50571249
Antipsychotic drug level above therapeutic	23.86	13.76	12	33644	947	50570521
Psychomotor retardation	23.62	13.76	19	33637	3399	50568069
Diarrhoea	23.28	13.76	265	33391	588211	49983257
Freezing phenomenon	23.21	13.76	12	33644	1003	50570465
Sepsis	22.93	13.76	33	33623	132892	50438576
Blood testosterone increased	22.86	13.76	7	33649	143	50571325
Vertigo	22.70	13.76	81	33575	51751	50519717
Distributive shock	22.34	13.76	11	33645	829	50570639
Upper respiratory tract infection	22.24	13.76	8	33648	65890	50505578
Hepatic enzyme increased	21.88	13.76	36	33620	137344	50434124
Medulloblastoma	21.73	13.76	5	33651	31	50571437
Analgesic drug level above therapeutic	21.64	13.76	7	33649	172	50571296
Hypoaesthesia	21.55	13.76	32	33624	127225	50444243
Therapeutic response decreased	21.38	13.76	3	33653	47228	50524240
Mixed liver injury	21.37	13.76	18	33638	3433	50568035
Sudden death	21.21	13.76	28	33628	8963	50562505
Hypertonia	21.13	13.76	19	33637	3954	50567514
Foetal growth restriction	21.09	13.76	24	33632	6603	50564865
Pruritus	21.05	13.76	107	33549	283461	50288007
COVID-19	21.04	13.76	3	33653	46659	50524809
Chest pain	20.88	13.76	55	33601	176827	50394641
Medication error	20.85	13.76	62	33594	36042	50535426
Urticaria	20.59	13.76	34	33622	129527	50441941
Hypercapnia	20.52	13.76	20	33636	4607	50566861
Gamma-glutamyltransferase increased	20.17	13.76	54	33602	29569	50541899
Apnoea	20.12	13.76	24	33632	6942	50564526
Herpes zoster	20.10	13.76	11	33645	70775	50500693
Bezoar	20.03	13.76	12	33644	1336	50570132
Electrocardiogram QRS complex abnormal	19.98	13.76	7	33649	221	50571247
Feeling abnormal	19.88	13.76	33	33623	125459	50446009
Cholinergic syndrome	19.85	13.76	8	33648	374	50571094
Retrograde amnesia	19.29	13.76	8	33648	403	50571065
Needle track marks	19.26	13.76	4	33652	14	50571454
Delusion	19.14	13.76	29	33627	10540	50560928
Stoma site erythema	18.85	13.76	10	33646	881	50570587
Cardioactive drug level above therapeutic	18.72	13.76	6	33650	143	50571325
Pelvic fracture	18.62	13.76	30	33626	11490	50559978
Nightmare	18.39	13.76	36	33620	16050	50555418
Galactorrhoea	18.23	13.76	17	33639	3706	50567762
Flushing	18.20	13.76	11	33645	67004	50504464
Anal paraesthesia	18.11	13.76	4	33652	20	50571448
Genital paraesthesia	18.11	13.76	4	33652	20	50571448
Stoma site discharge	18.04	13.76	11	33645	1264	50570204
Musculoskeletal pain	18.04	13.76	13	33643	72164	50499304
Salivary hypersecretion	17.88	13.76	22	33634	6569	50564899
Psoriasis	17.81	13.76	12	33644	68988	50502480
Adenocarcinoma metastatic	17.77	13.76	5	33651	75	50571393
Fibroma	17.71	13.76	9	33647	726	50570742
Therapy non-responder	17.55	13.76	6	33650	51016	50520452
Megacolon	17.44	13.76	12	33644	1694	50569774
Platelet count decreased	17.38	13.76	25	33631	100701	50470767
Hospitalisation	17.29	13.76	12	33644	67925	50503543
Hepatic cytolysis	17.24	13.76	24	33632	8079	50563389
Major depression	17.12	13.76	22	33634	6862	50564606
Palatal swelling	17.08	13.76	5	33651	87	50571381
Impaired healing	16.89	13.76	13	33643	69773	50501695
Head discomfort	16.87	13.76	28	33628	10991	50560477
Antipsychotic drug level increased	16.79	13.76	15	33641	3094	50568374
Enanthema	16.52	13.76	7	33649	372	50571096
Injury	16.41	13.76	6	33650	48919	50522549
Hypopnoea	16.39	13.76	13	33643	2280	50569188
Subileus	16.29	13.76	14	33642	2745	50568723
Lipohypertrophy	16.22	13.76	8	33648	605	50570863
Influenza like illness	16.21	13.76	9	33647	57450	50514018
Drug level increased	16.13	13.76	38	33618	19230	50552238
Irritable bowel syndrome	16.12	13.76	7	33649	51434	50520034
Psychotic symptom	15.99	13.76	10	33646	1202	50570266
Nasal congestion	15.95	13.76	7	33649	51113	50520355
Nausea	15.94	13.76	353	33303	705045	49866423
Diarrhoea infectious	15.70	13.76	9	33647	923	50570545
Therapeutic product effect incomplete	15.50	13.76	23	33633	91492	50479976
Thrombosis	15.39	13.76	9	33647	55824	50515644
Concussion	15.35	13.76	22	33634	7606	50563862
Chondropathy	15.21	13.76	12	33644	2088	50569380
Adverse drug reaction	15.08	13.76	9	33647	55213	50516255
Blood cholesterol increased	15.08	13.76	9	33647	55206	50516262
Gastrointestinal disorder	14.81	13.76	25	33631	94431	50477037
Frontotemporal dementia	14.80	13.76	6	33650	285	50571183
Mutism	14.80	13.76	10	33646	1371	50570097
Influenza	14.69	13.76	23	33633	89515	50481953
Adenocarcinoma gastric	14.66	13.76	7	33649	493	50570975
Anterograde amnesia	14.64	13.76	7	33649	495	50570973
Action tremor	14.58	13.76	6	33650	296	50571172
Haematoma	14.50	13.76	49	33607	30461	50541007
Dehydration	14.43	13.76	160	33496	152289	50419179
Amyotrophy	14.39	13.76	5	33651	154	50571314
Hyperkinesia	14.34	13.76	10	33646	1442	50570026
Suspected counterfeit product	14.28	13.76	6	33650	312	50571156
Pneumothorax traumatic	14.27	13.76	5	33651	158	50571310
Therapeutic response increased	14.21	13.76	6	33650	316	50571152
Subcutaneous haematoma	13.96	13.76	10	33646	1505	50569963
Nephrolithiasis	13.96	13.76	3	33653	34690	50536778
Immobile	13.92	13.76	17	33639	5037	50566431
Injection site reaction	13.88	13.76	8	33648	50024	50521444
Hypercapnic coma	13.86	13.76	5	33651	172	50571296
Irregular sleep wake rhythm disorder	13.81	13.76	5	33651	174	50571294

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	970.16	15.11	896	21441	172765	29379425
Coma	536.93	15.11	347	21990	39103	29513087
Drug abuse	493.81	15.11	438	21899	79445	29472745
Poisoning deliberate	250.46	15.11	110	22227	5621	29546569
Drug dependence	237.94	15.11	165	22172	20816	29531374
Asphyxia	225.75	15.11	100	22237	5215	29546975
Miosis	212.46	15.11	109	22228	7900	29544290
Overdose	191.59	15.11	267	22070	79552	29472638
Depressed level of consciousness	191.52	15.11	184	22153	36758	29515432
Intentional overdose	173.97	15.11	178	22159	38350	29513840
Somnolence	165.35	15.11	272	22065	93683	29458507
Drug use disorder	157.04	15.11	68	22269	3354	29548836
Aggression	149.30	15.11	158	22179	35383	29516807
Logorrhoea	140.58	15.11	56	22281	2232	29549958
Suicide attempt	124.74	15.11	141	22196	33969	29518221
Substance abuse	118.21	15.11	70	22267	6717	29545473
Hepatocellular injury	114.17	15.11	108	22229	21135	29531055
Abnormal behaviour	108.24	15.11	109	22228	23018	29529172
Respiratory depression	99.14	15.11	82	22255	13441	29538749
Altered state of consciousness	95.38	15.11	95	22242	19794	29532396
Dysarthria	91.90	15.11	115	22222	30796	29521394
Restlessness	88.62	15.11	96	22241	22049	29530141
Bezoar	79.39	15.11	28	22309	791	29551399
Alcohol abuse	76.26	15.11	45	22292	4288	29547902
Intentional self-injury	73.99	15.11	67	22270	12394	29539796
Agitation	73.72	15.11	136	22201	51168	29501022
Confusional state	71.87	15.11	236	22101	127641	29424549
Bradykinesia	69.20	15.11	39	22298	3408	29548782
Poisoning	67.88	15.11	58	22279	9935	29542255
Bradypnoea	62.07	15.11	32	22305	2339	29549851
Intentional product misuse	61.67	15.11	101	22236	34560	29517630
Hypothermia	59.46	15.11	52	22285	9187	29543003
Dystonic tremor	59.00	15.11	16	22321	181	29552009
Hamartoma	55.82	15.11	12	22325	44	29552146
Drug screen positive	55.42	15.11	35	22302	3766	29548424
Bradyphrenia	54.54	15.11	36	22301	4178	29548012
Drug interaction	53.17	15.11	291	22046	197094	29355096
Mania	52.25	15.11	47	22290	8616	29543574
Housebound	51.93	15.11	15	22322	217	29551973
Disturbance in attention	51.73	15.11	72	22265	21352	29530838
Mydriasis	51.17	15.11	40	22297	6045	29546145
Oesophageal obstruction	47.02	15.11	16	22321	405	29551785
Cardiac failure congestive	46.03	15.11	3	22334	76578	29475612
Pneumonia aspiration	44.92	15.11	91	22246	36646	29515544
Homicide	44.41	15.11	19	22318	909	29551281
Bladder dilatation	44.19	15.11	21	22316	1287	29550903
Withdrawal syndrome	42.82	15.11	47	22290	10945	29541245
Respiratory acidosis	42.02	15.11	31	22306	4297	29547893
Eosinophilic myocarditis	41.99	15.11	15	22322	440	29551750
Platelet count decreased	40.92	15.11	14	22323	104658	29447532
Product dose omission issue	39.25	15.11	12	22325	96371	29455819
Respiratory distress	38.62	15.11	79	22258	32027	29520163
Hallucination, visual	38.57	15.11	52	22285	14963	29537227
Melanoderma	38.41	15.11	11	22326	154	29552036
Brain oedema	37.15	15.11	46	22291	12174	29540016
Tachycardia	35.66	15.11	128	22209	72282	29479908
Electrocardiogram QT prolonged	35.57	15.11	82	22255	36055	29516135
Accidental overdose	35.04	15.11	54	22283	17539	29534651
Disorientation	34.76	15.11	72	22265	29443	29522747
Fatigue	34.07	15.11	124	22213	316697	29235493
Victim of crime	33.31	15.11	12	22325	361	29551829
Nausea	33.26	15.11	110	22227	289145	29263045
Wrong patient received product	33.24	15.11	21	22316	2261	29549929
Hepatic fibrosis	33.17	15.11	24	22313	3228	29548962
Hyper IgE syndrome	33.05	15.11	8	22329	55	29552135
Vasoplegia syndrome	32.83	15.11	18	22319	1490	29550700
Hyperthermia	32.77	15.11	38	22299	9392	29542798
Pulmonary oedema	32.61	15.11	88	22249	42647	29509543
Rhabdomyolysis	32.10	15.11	110	22227	60698	29491492
Arthralgia	31.96	15.11	35	22302	139582	29412608
Oesophageal haemorrhage	31.45	15.11	16	22321	1137	29551053
Neuroleptic malignant syndrome	31.37	15.11	49	22288	16099	29536091
Drug hypersensitivity	30.72	15.11	7	22330	68399	29483791
Psychotic behaviour	30.40	15.11	13	22324	621	29551569
Back pain	30.30	15.11	20	22317	102264	29449926
Mixed liver injury	30.19	15.11	19	22318	2032	29550158
Pain	30.18	15.11	52	22285	171380	29380810
White blood cell count decreased	29.51	15.11	13	22324	83349	29468841
Hyponatraemia	29.50	15.11	115	22222	67518	29484672
Cholestatic liver injury	28.23	15.11	17	22320	1680	29550510
Psychotic disorder	28.00	15.11	53	22284	20301	29531889
Hyperdynamic left ventricle	27.74	15.11	8	22329	115	29552075
Dyskinesia	27.31	15.11	52	22285	20009	29532181
Accidental death	27.18	15.11	18	22319	2100	29550090
Extrapyramidal disorder	27.04	15.11	37	22300	10794	29541396
Hypoosmolar state	26.78	15.11	7	22330	68	29552122
Food aversion	26.65	15.11	10	22327	338	29551852
Behaviour disorder	26.64	15.11	22	22315	3594	29548596
Cough	26.61	15.11	34	22303	126693	29425497
Cholestasis	26.19	15.11	56	22281	23406	29528784
Pain in extremity	26.03	15.11	27	22310	110406	29441784
Urticaria	25.76	15.11	5	22332	54655	29497535
Diarrhoea	25.18	15.11	148	22189	332550	29219640
Urticaria chronic	25.06	15.11	7	22330	89	29552101
Fall	24.88	15.11	223	22114	176955	29375235
Consciousness fluctuating	24.85	15.11	13	22324	979	29551211
Pleurothotonus	24.30	15.11	13	22324	1025	29551165
Disease progression	24.28	15.11	16	22321	81900	29470290
Peripheral swelling	24.08	15.11	9	22328	63730	29488460
Acute myocardial infarction	23.76	15.11	4	22333	48434	29503756
Neuropathy peripheral	23.71	15.11	12	22325	71015	29481175
Muscle rigidity	23.27	15.11	32	22305	9379	29542811
Hepatic cytolysis	23.12	15.11	30	22307	8317	29543873
Rash	22.59	15.11	71	22266	189748	29362442
Chest pain	22.52	15.11	31	22306	111942	29440248
Rheumatoid nodule	22.42	15.11	16	22321	2106	29550084
Hepatitis acute	22.38	15.11	26	22311	6436	29545754
Sepsis	21.85	15.11	47	22290	142635	29409555
Dyspnoea	21.81	15.11	151	22186	326581	29225609
Pulmonary congestion	21.78	15.11	36	22301	12400	29539790
Analgesic drug level increased	21.52	15.11	10	22327	582	29551608
Myoclonus	21.29	15.11	37	22300	13272	29538918
Hepatorenal syndrome	21.23	15.11	16	22321	2290	29549900
Pruritus	20.95	15.11	35	22302	116814	29435376
Disturbance in social behaviour	20.72	15.11	14	22323	1688	29550502
Coordination abnormal	20.38	15.11	26	22311	7088	29545102
Thrombosis	20.15	15.11	4	22333	43041	29509149
Antasthmatic drug level	19.99	15.11	5	22332	40	29552150
Analgesic drug level	19.99	15.11	5	22332	40	29552150
Otospondylomegaepiphyseal dysplasia	19.55	15.11	6	22331	108	29552082
Pneumonia	19.43	15.11	152	22185	320020	29232170
Headache	19.38	15.11	67	22270	173940	29378250
Emotional disorder	19.05	15.11	21	22316	4910	29547280
Coagulation factor VII level decreased	19.01	15.11	6	22331	119	29552071
Patient uncooperative	18.99	15.11	8	22329	368	29551822
Metabolic acidosis	18.88	15.11	67	22270	37595	29514595
Toxic epidermal necrolysis	18.75	15.11	42	22295	18111	29534079
Loss of consciousness	18.40	15.11	107	22230	73949	29478241
Apathy	18.38	15.11	23	22314	6148	29546042
Stomatitis	18.34	15.11	3	22334	37110	29515080
Congestive hepatopathy	18.29	15.11	13	22324	1701	29550489
Eye haematoma	18.09	15.11	5	22332	61	29552129
Colitis ischaemic	17.82	15.11	22	22315	5801	29546389
Drug level increased	17.78	15.11	42	22295	18745	29533445
Muscle contracture	17.77	15.11	11	22326	1142	29551048
Sedation	17.67	15.11	40	22297	17365	29534825
Prescription form tampering	17.58	15.11	8	22329	444	29551746
Tonic convulsion	17.20	15.11	10	22327	926	29551264
Priapism	17.15	15.11	19	22318	4469	29547721
Constipation	17.14	15.11	38	22299	114122	29438068
Drug ineffective	17.01	15.11	184	22153	362986	29189204
Pyrexia	16.76	15.11	138	22199	287484	29264706
Neutrophil count decreased	16.71	15.11	6	22331	43561	29508629
Agranulocytosis	16.64	15.11	43	22294	20297	29531893
Hospitalisation	16.54	15.11	7	22330	45981	29506209
Cellulitis	16.45	15.11	7	22330	45833	29506357
Foetal growth restriction	16.24	15.11	17	22320	3749	29548441
Vestibular disorder	16.11	15.11	10	22327	1044	29551146
Blood disorder	15.98	15.11	15	22322	2902	29549288
Spinal cord injury thoracic	15.89	15.11	5	22332	98	29552092
Prothrombin time shortened	15.84	15.11	11	22326	1387	29550803
Drug diversion	15.76	15.11	9	22328	806	29551384
Cerebrovascular accident	15.75	15.11	21	22316	76890	29475300
Cognitive disorder	15.57	15.11	46	22291	23453	29528737
COVID-19	15.55	15.11	4	22333	36010	29516180
Judgement impaired	15.52	15.11	8	22329	584	29551606
Off label use	15.47	15.11	149	22188	300651	29251539
Serotonin syndrome	15.34	15.11	38	22299	17474	29534716
Tachyphrenia	15.16	15.11	10	22327	1159	29551031

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	1865.72	12.82	1824	48904	361689	64086315
Coma	1193.93	12.82	783	49945	86832	64361172
Depressed level of consciousness	863.69	12.82	624	50104	80812	64367192
Poisoning deliberate	738.26	12.82	307	50421	13151	64434853
Sedation complication	590.88	12.82	243	50485	10111	64437893
Drug abuse	589.40	12.82	618	50110	131756	64316248
Sedation	572.19	12.82	374	50354	41088	64406916
Intentional overdose	562.18	12.82	506	50222	89438	64358566
Orthostatic hypotension	538.51	12.82	377	50351	46361	64401643
Creatinine renal clearance decreased	522.78	12.82	246	50482	14175	64433829
Cognitive disorder	493.95	12.82	382	50346	54705	64393299
Somnolence	451.56	12.82	670	50058	202975	64245029
Fall	414.19	12.82	970	49758	415856	64032148
Blood calcium decreased	385.75	12.82	244	50484	25310	64422694
Miosis	346.20	12.82	181	50547	13085	64434919
Drug dependence	345.15	12.82	252	50476	33060	64414944
Suicide attempt	343.55	12.82	347	50381	70660	64377344
Overdose	340.54	12.82	516	50212	159050	64288954
Intentional self-injury	338.40	12.82	236	50492	28808	64419196
Balance disorder	314.14	12.82	358	50370	83568	64364436
Asphyxia	309.61	12.82	151	50577	9415	64438589
Hypotension	284.79	12.82	797	49931	380177	64067827
Mobility decreased	216.98	12.82	301	50427	85539	64362465
Hyponatraemia	216.54	12.82	405	50323	147934	64300070
Hepatocellular injury	214.91	12.82	219	50509	45016	64402988
Aggression	203.76	12.82	215	50513	46017	64401987
Drug use disorder	191.22	12.82	94	50634	5960	64442044
Respiratory depression	183.04	12.82	150	50578	23293	64424711
Electrocardiogram QT prolonged	180.76	12.82	265	50463	79183	64368821
Confusional state	163.84	12.82	514	50214	260630	64187374
Drug interaction	142.81	12.82	613	50115	361470	64086534
Altered state of consciousness	135.48	12.82	158	50570	37744	64410260
Hypothermia	134.34	12.82	117	50611	19739	64428265
Pneumonia aspiration	129.46	12.82	194	50534	59077	64388927
Drug ineffective	129.25	12.82	295	50433	839952	63608052
Poisoning	120.75	12.82	115	50613	21764	64426240
Abnormal behaviour	119.90	12.82	140	50588	33482	64414522
Logorrhoea	116.31	12.82	59	50669	4000	64444004
Rhabdomyolysis	116.11	12.82	236	50492	91490	64356514
Cholestasis	115.78	12.82	159	50569	44713	64403291
Substance abuse	114.04	12.82	78	50650	9214	64438790
Drug hypersensitivity	111.99	12.82	25	50703	237790	64210214
Arthralgia	110.61	12.82	111	50617	442149	64005855
Intentional product misuse	107.35	12.82	199	50529	72096	64375908
Constipation	106.74	12.82	409	50319	228928	64219076
Bladder dilatation	103.99	12.82	43	50685	1811	64446193
Bradycardia	102.69	12.82	262	50466	117957	64330047
Restlessness	102.68	12.82	141	50587	39644	64408360
Rash	97.51	12.82	131	50597	458418	63989586
Product dose omission issue	94.69	12.82	19	50709	194728	64253276
Bradypnoea	92.46	12.82	55	50673	5104	64442900
Disturbance in attention	91.90	12.82	136	50592	40938	64407066
Peripheral swelling	87.10	12.82	28	50700	209125	64238879
Hallucination, visual	86.34	12.82	108	50620	27726	64420278
Headache	86.00	12.82	180	50548	529287	63918717
Wrong patient received product	85.95	12.82	47	50681	3715	64444289
Agitation	84.27	12.82	203	50525	88164	64359840
Bezoar	84.19	12.82	39	50689	2164	64445840
Alcohol abuse	82.48	12.82	50	50678	4802	64443202
Housebound	80.99	12.82	25	50703	440	64447564
Respiratory acidosis	78.89	12.82	64	50664	9791	64438213
Hyperthermia	76.95	12.82	77	50651	15473	64432531
Joint swelling	76.28	12.82	37	50691	215345	64232659
Fatigue	74.43	12.82	320	50408	748410	63699594
Cardiac failure congestive	71.88	12.82	9	50719	130571	64317433
Dysarthria	71.79	12.82	150	50578	59256	64388748
Drug intolerance	71.76	12.82	29	50699	187963	64260041
Back pain	70.58	12.82	56	50672	250115	64197889
Rheumatoid arthritis	70.18	12.82	21	50707	164273	64283731
Sinusitis	69.35	12.82	15	50713	145913	64302091
Pain in extremity	68.05	12.82	83	50645	303002	64145002
Swelling	67.49	12.82	21	50707	160197	64287807
Mydriasis	67.05	12.82	71	50657	15241	64432763
Abdominal discomfort	66.59	12.82	30	50698	182292	64265712
Lactic acidosis	66.13	12.82	148	50580	61262	64386742
Cough	64.46	12.82	86	50642	302062	64145942
Treatment failure	64.42	12.82	8	50720	116808	64331196
Neuroleptic malignant syndrome	59.15	12.82	85	50643	24911	64423093
Platelet count decreased	59.08	12.82	29	50699	167682	64280322
Arthropathy	58.36	12.82	12	50716	120955	64327049
Dystonic tremor	58.35	12.82	16	50712	181	64447823
Apathy	58.13	12.82	57	50671	11175	64436829
Inappropriate antidiuretic hormone secretion	57.50	12.82	79	50649	22210	64425794
Infusion related reaction	57.09	12.82	29	50699	164438	64283566
Akathisia	56.96	12.82	57	50671	11453	64436551
Disorientation	56.18	12.82	131	50597	55697	64392307
Bradykinesia	55.48	12.82	44	50684	6516	64441488
Hypersensitivity	55.36	12.82	44	50684	196408	64251596
Loss of consciousness	55.08	12.82	247	50481	148118	64299886
Lower respiratory tract infection	53.35	12.82	6	50722	94608	64353396
Extrapyramidal disorder	53.02	12.82	71	50657	19481	64428523
Reduced facial expression	52.75	12.82	28	50700	2085	64445919
Patient uncooperative	52.74	12.82	19	50709	548	64447456
Dyspnoea	51.90	12.82	342	50386	718332	63729672
Accidental overdose	51.84	12.82	94	50634	33463	64414541
Injection site pain	51.82	12.82	12	50716	111396	64336608
White blood cell count decreased	51.62	12.82	30	50698	157807	64290197
Behaviour disorder	51.33	12.82	36	50692	4426	64443578
Disease progression	50.66	12.82	24	50704	141656	64306348
Stomatitis	48.66	12.82	13	50715	109592	64338412
Acute kidney injury	48.45	12.82	553	50175	448687	63999317
Prescription form tampering	48.24	12.82	16	50712	358	64447646
Drug screen positive	47.54	12.82	38	50690	5691	64442313
Therapeutic product effect decreased	47.02	12.82	16	50712	115335	64332669
Pneumonia	46.83	12.82	254	50474	559322	63888682
Diarrhoea	46.28	12.82	356	50372	722348	63725656
Sepsis	44.72	12.82	70	50658	230271	64217733
Nasopharyngitis	44.71	12.82	53	50675	196020	64251984
Nausea	44.47	12.82	400	50328	785400	63662604
Suicidal ideation	44.38	12.82	134	50594	66408	64381596
Respiratory distress	44.38	12.82	115	50613	52216	64395788
Tachycardia	44.00	12.82	233	50495	149346	64298658
Pyrexia	43.81	12.82	259	50469	558385	63889619
Hypokalaemia	43.78	12.82	201	50527	121702	64326302
Chest pain	43.68	12.82	74	50654	235906	64212098
Systemic lupus erythematosus	43.56	12.82	5	50723	77607	64370397
Oxygen saturation decreased	43.25	12.82	183	50545	106993	64341011
Benzodiazepine drug level increased	43.15	12.82	13	50715	210	64447794
Victim of sexual abuse	43.03	12.82	15	50713	392	64447612
Mixed liver injury	42.62	12.82	35	50693	5446	64442558
Urticaria	41.49	12.82	33	50695	147284	64300720
Drug level above therapeutic	41.39	12.82	38	50690	6863	64441141
Off label use	40.81	12.82	311	50417	632495	63815509
Contraindicated product administered	40.53	12.82	17	50711	107812	64340192
Prothrombin time ratio decreased	40.24	12.82	17	50711	756	64447248
Bradyphrenia	40.09	12.82	43	50685	9363	64438641
Glossodynia	39.41	12.82	3	50725	64693	64383311
Infection	39.00	12.82	53	50675	184827	64263177
Haemodynamic instability	38.69	12.82	53	50675	14859	64433145
Victim of crime	38.56	12.82	14	50714	413	64447591
Urinary retention	38.55	12.82	105	50623	49096	64398908
Withdrawal syndrome	37.81	12.82	67	50661	23425	64424579
Pruritus	37.74	12.82	123	50605	312277	64135727
Psychomotor skills impaired	37.35	12.82	28	50700	3817	64444187
Homicide	36.73	12.82	18	50710	1133	64446871
Cholestatic liver injury	36.20	12.82	27	50701	3652	64444352
Neuropathy peripheral	36.12	12.82	24	50704	117501	64330503
Oesophageal obstruction	36.05	12.82	16	50712	803	64447201
Upper respiratory tract infection	35.56	12.82	7	50721	72778	64375226
Alopecia	35.45	12.82	47	50681	165643	64282361
Therapy non-responder	35.16	12.82	5	50723	65894	64382110
Hepatic cytolysis	33.57	12.82	48	50680	14001	64434003
Blister	33.39	12.82	11	50717	80956	64367048
Wheezing	33.14	12.82	11	50717	80568	64367436
Serotonin syndrome	32.97	12.82	86	50642	39196	64408808
COVID-19	32.39	12.82	6	50722	65134	64382870
Eosinophilic myocarditis	32.30	12.82	15	50713	837	64447167
Pleurothotonus	32.28	12.82	21	50707	2281	64445723
Delirium	30.95	12.82	122	50606	69072	64378932
Hand deformity	30.74	12.82	6	50722	62765	64385239
Encephalopathy	30.72	12.82	109	50619	58710	64389294
Pericarditis	30.57	12.82	6	50722	62510	64385494
Wound	30.48	12.82	11	50717	76466	64371538
Drug level increased	29.87	12.82	76	50652	34120	64413884
Listless	29.84	12.82	23	50705	3267	64444737
Hepatitis	29.65	12.82	91	50637	45491	64402513
Mania	29.56	12.82	49	50679	16237	64431767
Melanoderma	29.42	12.82	11	50717	353	64447651
Neutrophil count decreased	29.28	12.82	12	50716	77184	64370820
Hypoaesthesia	29.21	12.82	40	50688	139068	64308936
Subileus	29.06	12.82	27	50701	4950	64443054
Injection site erythema	28.53	12.82	10	50718	70790	64377214
Thrombosis	28.43	12.82	10	50718	70632	64377372
Wrong patient	27.85	12.82	9	50719	185	64447819
Psychotic disorder	27.29	12.82	74	50654	34504	64413500
Blood thyroid stimulating hormone normal	27.29	12.82	8	50720	117	64447887
Muscle rigidity	27.05	12.82	49	50679	17424	64430580
Faecal vomiting	26.77	12.82	14	50714	1011	64446993
Hypoventilation	26.56	12.82	28	50700	5978	64442026
Pulmonary oedema	26.24	12.82	127	50601	78547	64369457
Urinary tract infection	26.04	12.82	94	50634	231502	64216502
Brain oedema	25.79	12.82	55	50673	22020	64425984
Epilepsy	25.71	12.82	71	50657	33460	64414544
Flushing	25.63	12.82	15	50713	78633	64369371
Cerebrovascular accident	25.57	12.82	43	50685	137540	64310464
Food aversion	25.57	12.82	12	50716	686	64447318
Gamma-glutamyltransferase increased	25.42	12.82	90	50638	48420	64399584
Hypoosmolar state	25.13	12.82	9	50719	255	64447749
Hospitalisation	25.00	12.82	14	50714	75193	64372811
Nasal congestion	24.78	12.82	8	50720	59650	64388354
Mutism	24.78	12.82	17	50711	2017	64445987
Agranulocytosis	24.56	12.82	76	50652	38153	64409851
Victim of homicide	24.55	12.82	8	50720	169	64447835
Vasoplegia syndrome	24.35	12.82	19	50709	2748	64445256
Hypercapnia	24.09	12.82	30	50698	7664	64440340
Drug withdrawal convulsions	24.09	12.82	17	50711	2111	64445893
Influenza	24.05	12.82	29	50699	106502	64341502
Toxic epidermal necrolysis	23.99	12.82	74	50654	37092	64410912
Psychotic behaviour	23.91	12.82	13	50715	1016	64446988
Myocardial infarction	23.88	12.82	60	50668	165761	64282243
Hypocoagulable state	23.80	12.82	16	50712	1837	64446167
Weight increased	23.72	12.82	87	50641	213261	64234743
Feeling abnormal	23.70	12.82	43	50685	133559	64314445
Potentiating drug interaction	23.60	12.82	30	50698	7822	64440182
Hallucination, synaesthetic	23.53	12.82	6	50722	50	64447954
Therapeutic response decreased	23.52	12.82	6	50722	52182	64395822
Vascular purpura	23.47	12.82	18	50710	2538	64445466
Hypereosinophilic syndrome	22.97	12.82	10	50718	479	64447525
Dry skin	22.83	12.82	6	50722	51155	64396849
Cellulitis	22.77	12.82	24	50704	93633	64354371
Dyspnoea exertional	22.72	12.82	15	50713	73715	64374289
Wrong rate	22.64	12.82	6	50722	59	64447945
Oropharyngeal pain	22.49	12.82	22	50706	88845	64359159
Lung disorder	22.45	12.82	101	50627	60599	64387405
Delusion	22.35	12.82	46	50682	17968	64430036
Malignant neoplasm progression	22.17	12.82	34	50694	112837	64335167
Hypertonia	21.98	12.82	26	50702	6299	64441705
Fluid retention	21.44	12.82	10	50718	59596	64388408
Antipsychotic drug level above therapeutic	21.37	12.82	15	50713	1846	64446158
Accidental death	21.35	12.82	20	50708	3705	64444299
Distributive shock	21.27	12.82	15	50713	1860	64446144
Hepatic fibrosis	21.27	12.82	24	50704	5528	64442476
Tachyphrenia	21.26	12.82	15	50713	1861	64446143
Metabolic acidosis	21.16	12.82	111	50617	70847	64377157
Oesophageal haemorrhage	21.12	12.82	14	50714	1570	64446434
Chills	21.09	12.82	48	50680	137216	64310788
Prescription drug used without a prescription	21.05	12.82	17	50711	2583	64445421
Blood glucose increased	20.78	12.82	28	50700	98045	64349959
Abdominal distension	20.76	12.82	27	50701	95967	64352037
Hyperdynamic left ventricle	20.66	12.82	8	50720	283	64447721
Disturbance in social behaviour	20.63	12.82	20	50708	3867	64444137
Muscle spasms	20.33	12.82	51	50677	140972	64307032
Sudden death	20.04	12.82	47	50681	20049	64427955
Antasthmatic drug level	19.79	12.82	5	50723	40	64447964
Dyskinesia	19.72	12.82	72	50656	39316	64408688
Retrograde amnesia	19.59	12.82	9	50719	490	64447514
Coordination abnormal	19.50	12.82	39	50689	14925	64433079
Cytomegalovirus infection	19.43	12.82	3	50725	37196	64410808
Cataract	19.39	12.82	8	50720	51254	64396750
Analgesic drug level	19.37	12.82	5	50723	44	64447960
Hyperkalaemia	19.30	12.82	141	50587	100988	64347016
Neurological examination abnormal	19.30	12.82	9	50719	507	64447497
Myoclonus	19.07	12.82	53	50675	25065	64422939
Impaired healing	19.05	12.82	12	50716	60461	64387543
Erythema	19.05	12.82	79	50649	186991	64261013
Neurosensory hypoacusis	18.95	12.82	7	50721	217	64447787
Injection site bruising	18.85	12.82	3	50725	36370	64411634
Rhinorrhoea	18.75	12.82	12	50716	59957	64388047
Analgesic drug level increased	18.71	12.82	15	50713	2255	64445749
Megacolon	18.54	12.82	17	50711	3065	64444939
Asthma	18.40	12.82	29	50699	95196	64352808
Decreased appetite	18.17	12.82	138	50590	281151	64166853
Hypotonia	18.07	12.82	32	50696	11180	64436824
Poor feeding infant	17.97	12.82	6	50722	137	64447867
Galactorrhoea	17.91	12.82	17	50711	3202	64444802
Wrong technique in product usage process	17.73	12.82	15	50713	64959	64383045
Major depression	17.65	12.82	26	50702	7790	64440214
Foreign body	17.56	12.82	15	50713	2464	64445540
Salivary hypersecretion	17.53	12.82	33	50695	12080	64435924
Gastrointestinal haemorrhage	17.44	12.82	50	50678	132262	64315742
Anal paraesthesia	17.28	12.82	4	50724	21	64447983
Asthenia	17.28	12.82	235	50493	427809	64020195
Opiates positive	17.21	12.82	10	50718	888	64447116
Hepatic enzyme increased	17.21	12.82	49	50679	129894	64318110
Acute myocardial infarction	16.80	12.82	18	50710	69700	64378304
Gastrointestinal disorder	16.70	12.82	28	50700	89681	64358323
Priapism	16.66	12.82	18	50710	3952	64444052
Medulloblastoma	16.58	12.82	5	50723	81	64447923
Hyper IgE syndrome	16.57	12.82	8	50720	487	64447517
Atopic keratoconjunctivitis	16.56	12.82	4	50724	26	64447978
Colitis ischaemic	16.34	12.82	34	50694	13380	64434624
Consciousness fluctuating	16.29	12.82	12	50716	1593	64446411
Throat irritation	16.29	12.82	3	50725	32708	64415296
Chronic kidney disease	16.26	12.82	13	50715	57906	64390098
Eosinophilia	16.12	12.82	66	50662	38010	64409994
Psychomotor retardation	16.01	12.82	20	50708	5123	64442881
Rash pruritic	15.97	12.82	13	50715	57391	64390613
Persecutory delusion	15.97	12.82	18	50710	4140	64443864
Influenza like illness	15.93	12.82	15	50713	61687	64386317
Coagulation factor VII level decreased	15.75	12.82	6	50722	203	64447801
Adenocarcinoma metastatic	15.74	12.82	5	50723	97	64447907
Haematocrit decreased	15.68	12.82	12	50716	54643	64393361
Antisocial behaviour	15.60	12.82	8	50720	555	64447449
Myalgia	15.52	12.82	68	50660	158549	64289455
On and off phenomenon	15.36	12.82	14	50714	2505	64445499
Fungal infection	15.31	12.82	4	50724	34247	64413757
Red blood cell sedimentation rate increased	15.26	12.82	3	50725	31232	64416772
Coronary artery disease	15.24	12.82	15	50713	60418	64387586
Therapeutic product effect incomplete	15.24	12.82	37	50691	103445	64344559
Hepatitis acute	15.23	12.82	33	50695	13356	64434648
Respiratory alkalosis	15.19	12.82	17	50711	3880	64444124
Blood pressure increased	15.11	12.82	77	50651	172475	64275529
Injection site reaction	15.06	12.82	9	50719	46655	64401349
Accidental poisoning	15.05	12.82	11	50717	1442	64446562
Drug diversion	15.05	12.82	10	50718	1126	64446878
Theft	14.99	12.82	6	50722	232	64447772
Action tremor	14.93	12.82	7	50721	399	64447605
Eye haematoma	14.86	12.82	5	50723	117	64447887
Parkinsonism	14.75	12.82	34	50694	14339	64433665
Cardioactive drug level above therapeutic	14.71	12.82	6	50722	244	64447760
Psoriasis	14.66	12.82	21	50707	71682	64376322
Anterograde amnesia	14.63	12.82	8	50720	632	64447372
Spinal cord injury thoracic	14.63	12.82	5	50723	123	64447881
Antipsychotic drug level increased	14.52	12.82	19	50709	5096	64442908
Mental status changes	14.50	12.82	16	50712	61146	64386858
Analgesic drug level above therapeutic	14.49	12.82	7	50721	427	64447577
Pleural effusion	14.46	12.82	51	50677	126508	64321496
Hypopnoea	14.32	12.82	15	50713	3179	64444825
Full blood count abnormal	14.25	12.82	3	50725	29754	64418250
Urticaria chronic	14.23	12.82	7	50721	444	64447560
Genital paraesthesia	14.22	12.82	4	50724	50	64447954
Drug resistance	14.07	12.82	5	50723	35097	64412907
High-pitched crying	14.06	12.82	3	50725	10	64447994
Hepatorenal syndrome	14.02	12.82	16	50712	3730	64444274
Haematochezia	14.01	12.82	19	50709	66354	64381650
Drug withdrawal syndrome	13.85	12.82	55	50673	31236	64416768
Weight decreased	13.74	12.82	151	50577	285588	64162416
Palatal swelling	13.63	12.82	5	50723	152	64447852
Subcutaneous haematoma	13.60	12.82	13	50715	2470	64445534
Herpes zoster	13.58	12.82	26	50702	79161	64368843
Red blood cell count decreased	13.41	12.82	11	50717	48375	64399629
Anuria	13.41	12.82	39	50689	18925	64429079
Plasma cell myeloma	13.37	12.82	10	50718	46065	64401939
Insomnia	13.27	12.82	96	50632	197740	64250264
Muscle contracture	13.23	12.82	12	50716	2133	64445871
Abdominal pain upper	13.21	12.82	82	50646	174948	64273056
Post-injection delirium sedation syndrome	13.19	12.82	7	50721	521	64447483
Pulmonary congestion	13.11	12.82	45	50683	23835	64424169
Acute generalised exanthematous pustulosis	13.07	12.82	32	50696	14026	64433978
Dermo-hypodermitis	13.03	12.82	7	50721	534	64447470
Electrocardiogram QRS complex abnormal	12.87	12.82	7	50721	547	64447457

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N05BA04	NERVOUS SYSTEM PSYCHOLEPTICS ANXIOLYTICS Benzodiazepine derivatives
FDA CS	M0002356	Benzodiazepines
MeSH PA	D014151	Anti-Anxiety Agents
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D018682	GABA Agents
MeSH PA	D018757	GABA Modulators
MeSH PA	D006993	Hypnotics and Sedatives
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D014149	Tranquilizing Agents
CHEBI has role	CHEBI:35474	anti-anxiety agents
CHEBI has role	CHEBI:35703	Xenobiotic
CHEBI has role	CHEBI:78298	environmental contaminants
FDA EPC	N0000175694	Benzodiazepine

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Alcohol withdrawal delirium	indication	8635005
Anxiety	indication	48694002
Suicidal thoughts	contraindication	6471006
Disorder of lung	contraindication	19829001	DOID:850
Borderline personality disorder	contraindication	20010003	DOID:10930
Alcohol intoxication	contraindication	25702006
Shock	contraindication	27942005
Depressive disorder	contraindication	35489007
Low blood pressure	contraindication	45007003
Substance abuse	contraindication	66214007
Psychotic disorder	contraindication	69322001
Sleep apnea	contraindication	73430006	DOID:0050847
Decreased respiratory function	contraindication	80954004
Kidney disease	contraindication	90708001	DOID:557
Hypoalbuminemia	contraindication	119247004
Disease of liver	contraindication	235856003	DOID:409
Sleep automatism	contraindication	247962006
Syncope	contraindication	271594007
Pregnancy, function	contraindication	289908002
Coma	contraindication	371632003
Porphyria	contraindication	418470004
Behavioral Disorders	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.41	acidic
pKa2	11.87	acidic
pKa3	1.83	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
GABA-A receptor alpha-1/beta-3/gamma-2	Ion channel	P14867 P18507 P28472	GBRA1_HUMAN GBRG2_HUMAN GBRB3_HUMAN	POSITIVE ALLOSTERIC MODULATOR	IC50	7.75		WOMBAT-PK	CHEMBL

External reference:

ID	Source
4018020	VUID
N0000146364	NUI
D00464	KEGG_DRUG
4018020	VANDF
C0029997	UMLSCUI
CHEBI:7823	CHEBI
CHEMBL568	ChEMBL_ID
DB00842	DRUGBANK_ID
D010076	MESH_DESCRIPTOR_UI
4616	PUBCHEM_CID
7253	IUPHAR_LIGAND_ID
1507	INN_ID
6GOW6DWN2A	UNII
7781	RXNORM
4493	MMSL
5211	MMSL
d00040	MMSL
001462	NDDF
387455006	SNOMEDCT_US
79225003	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2067	CAPSULE, GELATIN COATED	10 mg	ORAL	ANDA	21 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2069	CAPSULE, GELATIN COATED	15 mg	ORAL	ANDA	21 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	0228-2073	CAPSULE, GELATIN COATED	30 mg	ORAL	ANDA	21 sections
OXAZEPAM	HUMAN PRESCRIPTION DRUG LABEL	1	16590-304	CAPSULE	15 mg	ORAL	ANDA	13 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	43353-074	CAPSULE, GELATIN COATED	30 mg	ORAL	ANDA	19 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	43353-965	CAPSULE	10 mg	ORAL	ANDA	20 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	43353-980	CAPSULE	30 mg	ORAL	ANDA	20 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	52817-290	CAPSULE	10 mg	ORAL	ANDA	21 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	52817-291	CAPSULE	15 mg	ORAL	ANDA	21 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	52817-292	CAPSULE	30 mg	ORAL	ANDA	21 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	62584-812	CAPSULE, GELATIN COATED	10 mg	ORAL	ANDA	25 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	62584-813	CAPSULE, GELATIN COATED	15 mg	ORAL	ANDA	25 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	62584-814	CAPSULE, GELATIN COATED	30 mg	ORAL	ANDA	25 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	67544-117	CAPSULE, GELATIN COATED	10 mg	ORAL	ANDA	19 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	67544-268	CAPSULE, GELATIN COATED	15 mg	ORAL	ANDA	19 sections
Oxazepam	HUMAN PRESCRIPTION DRUG LABEL	1	71610-639	CAPSULE	15 mg	ORAL	ANDA	21 sections