oxazepam Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 2015 604-75-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • oxazepam
  • droxacepam
  • durazepam
  • noctazepam
  • tazepam
  • zaxopam
A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia.
  • Molecular weight: 286.72
  • Formula: C15H11ClN2O2
  • CLOGP: 2.31
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 61.69
  • ALOGS: -3.51
  • ROTB: 1

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
50 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.05 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 6.98 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 97 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.59 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.04 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 6.70 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
June 4, 1965 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 812.97 13.11 807 27503 210959 46446793
Intentional overdose 788.34 13.11 490 27820 64454 46593298
Coma 620.07 13.11 405 27905 57944 46599808
Intentional self-injury 532.51 13.11 270 28040 23896 46633856
Poisoning deliberate 448.64 13.11 172 28138 7754 46649998
Depressed level of consciousness 420.98 13.11 295 28015 47274 46610478
Suicide attempt 308.04 13.11 260 28050 54776 46602976
Somnolence 298.46 13.11 418 27892 156103 46501649
Orthostatic hypotension 261.08 13.11 171 28139 24487 46633265
Fall 251.85 13.11 590 27720 328507 46329245
Sedation 247.74 13.11 161 28149 22749 46635003
Hyponatraemia 233.37 13.11 297 28013 101035 46556717
Sedation complication 209.43 13.11 80 28230 3565 46654187
Overdose 167.35 13.11 254 28056 101725 46556027
Electrocardiogram QT prolonged 163.91 13.11 178 28132 51147 46606605
Cognitive disorder 161.95 13.11 152 28158 36731 46621021
Creatinine renal clearance decreased 160.13 13.11 80 28230 6840 46650912
Hypotension 141.70 13.11 383 27927 232206 46425546
Drug dependence 140.92 13.11 108 28202 19793 46637959
Drug abuse 136.65 13.11 180 28130 63228 46594524
Asphyxia 130.43 13.11 64 28246 5262 46652490
Confusional state 128.67 13.11 293 28017 159599 46498153
Drug ineffective 128.21 13.11 134 28176 677704 45980048
Hepatocellular injury 126.40 13.11 120 28190 29402 46628350
Drug interaction 122.17 13.11 333 27977 202761 46454991
Prescription form tampering 116.45 13.11 34 28276 646 46657106
Bradycardia 115.62 13.11 170 28140 66128 46591624
Miosis 103.33 13.11 59 28251 6598 46651154
Pneumonia aspiration 103.28 13.11 111 28199 31494 46626258
Blood calcium decreased 100.02 13.11 80 28230 15593 46642159
Cholestasis 99.61 13.11 101 28209 26792 46630960
Rheumatoid arthritis 90.32 13.11 18 28292 240197 46417555
Drug hypersensitivity 88.13 13.11 20 28290 243805 46413947
Wrong patient received product 85.20 13.11 34 28276 1703 46656049
Balance disorder 82.96 13.11 144 28166 64377 46593375
Rhabdomyolysis 79.67 13.11 112 28198 41797 46615955
Respiratory depression 77.85 13.11 61 28249 11539 46646213
Product dose omission issue 76.58 13.11 7 28303 168513 46489239
Inappropriate antidiuretic hormone secretion 71.42 13.11 63 28247 14039 46643713
Lactic acidosis 71.05 13.11 95 28215 33814 46623938
Aggression 67.57 13.11 76 28234 22668 46635084
Bladder dilatation 63.43 13.11 22 28288 741 46657011
Hypokalaemia 62.73 13.11 154 28156 87870 46569882
Rash 61.08 13.11 76 28234 356436 46301316
Bradypnoea 58.36 13.11 31 28279 3008 46654744
Loss of consciousness 57.62 13.11 170 28140 108068 46549684
Hypothermia 56.90 13.11 52 28258 12131 46645621
Hyperthermia 55.64 13.11 43 28267 7971 46649781
Akathisia 52.70 13.11 41 28269 7673 46650079
Altered state of consciousness 51.35 13.11 67 28243 23281 46634471
Injection site pain 49.89 13.11 4 28306 107148 46550604
Abdominal discomfort 49.62 13.11 15 28295 151150 46506602
Headache 49.22 13.11 139 28171 478213 46179539
Peripheral swelling 47.86 13.11 18 28292 158053 46499699
Arthralgia 47.85 13.11 93 28217 364510 46293242
Hallucination, visual 46.84 13.11 56 28254 17817 46639935
Mydriasis 45.34 13.11 43 28267 10510 46647242
Tachycardia 45.16 13.11 148 28162 99474 46558278
Respiratory acidosis 44.90 13.11 34 28276 6114 46651638
Extrapyramidal disorder 44.81 13.11 44 28266 11224 46646528
Urinary retention 44.19 13.11 66 28244 25995 46631757
Acute kidney injury 43.60 13.11 268 28042 235587 46422165
Haemodynamic instability 42.12 13.11 36 28274 7689 46650063
Mobility decreased 42.08 13.11 105 28205 60489 46597263
Agitation 41.65 13.11 99 28211 55316 46602436
Patient uncooperative 41.34 13.11 11 28299 146 46657606
Drug intolerance 40.88 13.11 19 28291 147030 46510722
Sinusitis 40.59 13.11 14 28296 129754 46527998
Pneumonia 39.66 13.11 108 28202 376212 46281540
Suicidal ideation 39.46 13.11 98 28212 56284 46601468
Back pain 38.90 13.11 42 28268 209997 46447755
Constipation 38.13 13.11 207 28103 173890 46483862
Neuroleptic malignant syndrome 37.97 13.11 40 28270 11082 46646670
Disturbance in attention 37.39 13.11 68 28242 31492 46626260
Faecal vomiting 36.61 13.11 14 28296 625 46657127
Cardiac failure congestive 36.32 13.11 6 28304 91744 46566008
Hypocoagulable state 36.27 13.11 16 28294 1031 46656721
Disorientation 35.72 13.11 73 28237 36845 46620907
Poisoning 35.29 13.11 43 28267 13951 46643801
Benzodiazepine drug level increased 34.75 13.11 10 28300 180 46657572
Delirium 34.13 13.11 72 28238 37156 46620596
Abnormal behaviour 33.82 13.11 52 28258 21006 46636746
Joint swelling 33.27 13.11 31 28279 166042 46491710
Hypoventilation 32.86 13.11 24 28286 4086 46653666
Hypersensitivity 32.61 13.11 26 28284 150295 46507457
Housebound 32.53 13.11 10 28300 228 46657524
Hypotonia 32.47 13.11 32 28278 8197 46649555
Parkinsonism 31.53 13.11 31 28279 7917 46649835
Restlessness 31.52 13.11 56 28254 25468 46632284
Hepatitis 31.52 13.11 64 28246 32151 46625601
Drug use disorder 31.46 13.11 20 28290 2715 46655037
Prothrombin time ratio decreased 30.63 13.11 11 28299 411 46657341
Swelling 30.34 13.11 19 28291 124492 46533260
Accidental overdose 30.07 13.11 48 28262 20018 46637734
Apathy 30.06 13.11 29 28281 7239 46650513
Potentiating drug interaction 29.32 13.11 22 28288 3901 46653851
Wrong rate 29.30 13.11 7 28303 58 46657694
Epilepsy 29.21 13.11 52 28258 23686 46634066
Prescription drug used without a prescription 28.91 13.11 15 28295 1387 46656365
Eosinophilia 28.84 13.11 46 28264 19171 46638581
Listless 28.83 13.11 17 28293 2018 46655734
Distributive shock 28.37 13.11 11 28299 510 46657242
Neurological examination abnormal 28.27 13.11 9 28301 231 46657521
Blood thyroid stimulating hormone normal 28.23 13.11 8 28302 136 46657616
Hypereosinophilic syndrome 27.94 13.11 9 28301 240 46657512
Psychomotor skills impaired 27.70 13.11 17 28293 2169 46655583
Muscle rigidity 27.41 13.11 32 28278 9929 46647823
Pain in extremity 27.39 13.11 74 28236 258606 46399146
Hyperkalaemia 27.29 13.11 80 28230 50629 46607123
Hepatic infiltration eosinophilic 27.24 13.11 6 28304 33 46657719
Serotonin syndrome 27.20 13.11 51 28259 24169 46633583
Behaviour disorder 26.78 13.11 16 28294 1945 46655807
Drug withdrawal convulsions 26.66 13.11 14 28296 1327 46656425
Cough 26.59 13.11 63 28247 230186 46427566
Neuropathy peripheral 26.42 13.11 11 28299 90882 46566870
Intentional product misuse 25.98 13.11 75 28235 47053 46610699
Infection 25.51 13.11 26 28284 133566 46524186
Antipsychotic drug level above therapeutic 25.12 13.11 12 28298 929 46656823
Antisocial behaviour 24.85 13.11 8 28302 213 46657539
Drug level above therapeutic 24.73 13.11 19 28291 3490 46654262
Oxygen saturation decreased 24.67 13.11 95 28215 69069 46588683
Mixed liver injury 24.33 13.11 18 28292 3125 46654627
Cholinergic syndrome 24.15 13.11 9 28301 374 46657378
Nasopharyngitis 24.10 13.11 35 28275 153963 46503789
Medication error 24.06 13.11 56 28254 30855 46626897
Herpes zoster 23.63 13.11 6 28304 67866 46589886
Arthropathy 23.44 13.11 11 28299 84689 46573063
Blood testosterone increased 23.36 13.11 7 28303 146 46657606
Injection site erythema 23.32 13.11 8 28302 74419 46583333
Respiratory alkalosis 22.71 13.11 16 28294 2575 46655177
Neurosensory hypoacusis 22.22 13.11 8 28302 301 46657451
Sepsis 22.19 13.11 30 28280 135984 46521768
Psoriasis 22.07 13.11 10 28300 78594 46579158
Analgesic drug level above therapeutic 21.76 13.11 7 28303 186 46657566
Medulloblastoma 21.43 13.11 5 28305 37 46657715
Retrograde amnesia 21.41 13.11 8 28302 335 46657417
White blood cell count decreased 21.25 13.11 22 28288 112209 46545543
Victim of sexual abuse 21.02 13.11 9 28301 539 46657213
Feeling abnormal 20.99 13.11 27 28283 125033 46532719
Therapeutic product effect decreased 20.97 13.11 12 28298 82589 46575163
Disease progression 20.80 13.11 15 28295 91285 46566467
Hypertonia 20.73 13.11 19 28291 4447 46653305
Electrocardiogram QRS complex abnormal 20.52 13.11 7 28303 224 46657528
Sudden death 20.47 13.11 27 28283 9477 46648275
Hypercapnia 20.16 13.11 19 28291 4607 46653145
Withdrawal syndrome 20.13 13.11 38 28272 18096 46639656
Wheezing 20.02 13.11 4 28306 53382 46604370
Gamma-glutamyltransferase increased 19.95 13.11 53 28257 31687 46626065
Drug level increased 19.68 13.11 38 28272 18403 46639349
Needle track marks 19.63 13.11 4 28306 14 46657738
Upper respiratory tract infection 19.62 13.11 7 28303 63549 46594203
Psychomotor retardation 19.55 13.11 16 28294 3217 46654535
Psychotic symptom 19.53 13.11 10 28300 900 46656852
Reduced facial expression 19.43 13.11 11 28299 1209 46656543
Fatigue 19.30 13.11 257 28053 608440 46049312
Vertigo 18.97 13.11 72 28238 51976 46605776
Hallucination 18.96 13.11 70 28240 49881 46607871
Lower respiratory tract infection 18.92 13.11 5 28305 55084 46602668
Nightmare 18.70 13.11 35 28275 16563 46641189
Adenocarcinoma metastatic 18.61 13.11 5 28305 69 46657683
Hypoaesthesia 18.60 13.11 27 28283 118842 46538910
Palatal swelling 18.55 13.11 5 28305 70 46657682
Diarrhoea 17.82 13.11 236 28074 559366 46098386
Foreign body 17.34 13.11 12 28298 1876 46655876
Contraindicated product administered 17.11 13.11 14 28296 79933 46577819
Anterograde amnesia 17.02 13.11 7 28303 379 46657373
Flushing 16.96 13.11 9 28301 64605 46593147
Hypopnoea 16.79 13.11 13 28297 2415 46655337
Chest pain 16.78 13.11 53 28257 176271 46481481
Salivary hypersecretion 16.57 13.11 20 28290 6425 46651327
Action tremor 16.53 13.11 6 28304 231 46657521
Subileus 16.38 13.11 14 28296 2989 46654763
Mutism 16.19 13.11 10 28300 1290 46656462
Chemical submission 16.18 13.11 6 28304 246 46657506
Nausea 16.17 13.11 307 28003 687147 45970605
Alopecia 16.03 13.11 48 28262 162366 46495386
Diarrhoea infectious 15.95 13.11 9 28301 983 46656769
High-pitched crying 15.93 13.11 3 28307 6 46657746
Stomatitis 15.85 13.11 11 28299 68286 46589466
Enanthema 15.82 13.11 7 28303 454 46657298
Infusion related reaction 15.82 13.11 23 28287 101185 46556567
Amyotrophy 15.68 13.11 5 28305 129 46657623
Pyrexia 15.55 13.11 136 28174 348666 46309086
Glossodynia 15.29 13.11 4 28306 44369 46613383
Cardioactive drug level above therapeutic 15.23 13.11 5 28305 142 46657610
Defaecation disorder 15.22 13.11 6 28304 291 46657461
Lipohypertrophy 15.18 13.11 8 28302 764 46656988
Therapeutic response increased 15.12 13.11 6 28304 296 46657456
Neonatal intestinal obstruction 15.07 13.11 3 28307 9 46657743
Adenocarcinoma gastric 15.06 13.11 7 28303 510 46657242
Haematoma 15.01 13.11 48 28262 31824 46625928
Hypovolaemic shock 14.84 13.11 17 28293 5166 46652586
Pneumothorax traumatic 14.81 13.11 5 28305 155 46657597
Suspected counterfeit product 14.69 13.11 6 28304 319 46657433
Therapeutic response decreased 14.66 13.11 4 28306 43141 46614611
Oropharyngeal pain 14.65 13.11 14 28296 74154 46583598
Chondropathy 14.62 13.11 11 28299 1959 46655793
Apnoea 14.51 13.11 20 28290 7319 46650433
Pain 14.49 13.11 203 28107 476745 46181007
Hypercapnic coma 14.45 13.11 5 28305 167 46657585
Thrombosis 14.44 13.11 8 28302 56061 46601691
Dyspnoea 14.43 13.11 223 28087 515325 46142427
Platelet count decreased 14.43 13.11 24 28286 100000 46557752
Major depression 14.40 13.11 19 28291 6671 46651081
Delusion 14.40 13.11 25 28285 11163 46646589
Unevaluable event 14.40 13.11 5 28305 46170 46611582
Cytogenetic analysis abnormal 14.34 13.11 7 28303 569 46657183
Irregular sleep wake rhythm disorder 14.18 13.11 5 28305 177 46657575
Musculoskeletal pain 14.13 13.11 13 28297 70115 46587637
Neck pain 14.08 13.11 8 28302 55298 46602454
Respiratory distress 14.07 13.11 47 28263 31869 46625883
Cholestatic liver injury 14.04 13.11 11 28299 2079 46655673
Sinus rhythm 14.01 13.11 7 28303 598 46657154
Cleft palate 13.89 13.11 8 28302 909 46656843
Cerebellar haematoma 13.88 13.11 6 28304 368 46657384
Toxic epidermal necrolysis 13.80 13.11 37 28273 22241 46635511
Influenza like illness 13.72 13.11 9 28301 57561 46600191
Nasal congestion 13.70 13.11 6 28304 48107 46609645
Galactorrhoea 13.58 13.11 14 28296 3783 46653969
Injection site reaction 13.57 13.11 6 28304 47843 46609909
Substance abuser 13.55 13.11 3 28307 17 46657735
Lung disorder 13.45 13.11 57 28253 43247 46614505
Crystal arthropathy 13.43 13.11 5 28305 207 46657545
Vascular purpura 13.42 13.11 9 28301 1337 46656415
Injury 13.33 13.11 5 28305 44022 46613730
Influenza 13.27 13.11 21 28289 89249 46568503
Transaminases increased 13.24 13.11 42 28268 27719 46630033

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 945.95 15.39 834 18633 176349 29756662
Coma 473.37 15.39 306 19161 40143 29892868
Drug abuse 283.54 15.39 306 19161 81766 29851245
Poisoning deliberate 233.39 15.39 101 19366 5803 29927208
Intentional overdose 195.06 15.39 183 19284 41298 29891713
Drug dependence 173.14 15.39 129 19338 21166 29911845
Asphyxia 170.31 15.39 79 19388 5346 29927665
Somnolence 161.60 15.39 252 19215 96511 29836500
Depressed level of consciousness 161.47 15.39 159 19308 38063 29894948
Drug use disorder 156.56 15.39 64 19403 3184 29929827
Overdose 154.02 15.39 229 19238 84108 29848903
Miosis 148.92 15.39 81 19386 7695 29925316
Suicide attempt 133.76 15.39 141 19326 36556 29896455
Hepatocellular injury 109.45 15.39 107 19360 25364 29907647
Logorrhoea 100.25 15.39 41 19426 2041 29930970
Altered state of consciousness 88.04 15.39 85 19382 19834 29913177
Abnormal behaviour 87.23 15.39 95 19372 25528 29907483
Respiratory depression 80.98 15.39 64 19403 11439 29921572
Bezoar 80.35 15.39 28 19439 891 29932120
Intentional self-injury 75.90 15.39 66 19401 13466 29919545
Aggression 74.18 15.39 105 19362 36802 29896209
Alcohol abuse 73.72 15.39 45 19422 5308 29927703
Agitation 62.70 15.39 120 19347 53953 29879058
Hypothermia 58.42 15.39 49 19418 9518 29923493
Hamartoma 57.62 15.39 12 19455 44 29932967
Mania 54.08 15.39 46 19421 9108 29923903
Mydriasis 53.91 15.39 39 19428 6104 29926907
Confusional state 53.83 15.39 201 19266 134633 29798378
Substance abuse 53.52 15.39 41 19426 6999 29926012
Drug screen positive 53.01 15.39 34 19433 4373 29928638
Bradypnoea 51.19 15.39 25 19442 1896 29931115
Oesophageal obstruction 49.27 15.39 16 19451 408 29932603
Withdrawal syndrome 47.80 15.39 47 19420 11203 29921808
Homicide 44.97 15.39 19 19448 1027 29931984
Respiratory acidosis 44.65 15.39 30 19437 4172 29928839
Pneumonia aspiration 43.96 15.39 84 19383 37696 29895315
Wrong patient received product 43.54 15.39 22 19445 1795 29931216
Dysarthria 43.39 15.39 74 19393 30416 29902595
Dystonic tremor 43.34 15.39 11 19456 111 29932900
Intentional product misuse 42.72 15.39 79 19388 34588 29898423
Restlessness 42.03 15.39 62 19405 22537 29910474
Disturbance in attention 40.14 15.39 60 19407 22069 29910942
Melanoderma 38.80 15.39 11 19456 174 29932837
Victim of crime 37.92 15.39 12 19455 281 29932730
Respiratory distress 36.75 15.39 72 19395 32900 29900111
Eosinophilic myocarditis 36.71 15.39 13 19454 434 29932577
Platelet count decreased 36.07 15.39 12 19455 106117 29826894
Product dose omission issue 35.56 15.39 8 19459 91623 29841388
Hyperthermia 35.32 15.39 38 19429 10061 29922950
Tachycardia 34.58 15.39 116 19351 73623 29859388
Housebound 33.51 15.39 10 19457 191 29932820
Oesophageal haemorrhage 33.28 15.39 16 19451 1172 29931839
Electrocardiogram QT prolonged 32.61 15.39 72 19395 35763 29897248
Drug interaction 32.29 15.39 231 19236 199337 29733674
Hepatic fibrosis 32.03 15.39 23 19444 3557 29929454
Arthralgia 31.82 15.39 25 19442 135766 29797245
Fall 31.46 15.39 214 19253 181658 29751353
Accidental overdose 30.95 15.39 48 19419 18227 29914784
Fatigue 30.34 15.39 107 19360 320566 29612445
Hyponatraemia 30.00 15.39 104 19363 67098 29865913
Behaviour disorder 29.98 15.39 19 19448 2393 29930618
Nausea 29.51 15.39 97 19370 296860 29636151
Food aversion 29.35 15.39 10 19457 297 29932714
Brain oedema 29.02 15.39 38 19429 12360 29920651
Bladder dilatation 28.87 15.39 15 19452 1297 29931714
Cholestatic liver injury 28.77 15.39 16 19451 1585 29931426
Neuroleptic malignant syndrome 27.87 15.39 43 19424 16252 29916759
Disorientation 27.32 15.39 62 19405 31356 29901655
Hypoosmolar state 27.03 15.39 7 19460 77 29932934
Hallucination, visual 26.83 15.39 42 19425 16071 29916940
Consciousness fluctuating 26.75 15.39 13 19454 975 29932036
Drug hypersensitivity 26.54 15.39 6 19461 68513 29864498
Pulmonary congestion 26.22 15.39 36 19431 12251 29920760
Pain 26.21 15.39 45 19422 172596 29760415
Urticaria chronic 25.75 15.39 7 19460 94 29932917
Rhabdomyolysis 25.48 15.39 95 19372 63485 29869526
Extrapyramidal disorder 25.38 15.39 33 19434 10660 29922351
Rheumatoid nodule 25.32 15.39 15 19452 1675 29931336
Back pain 25.17 15.39 18 19449 102578 29830433
Pain in extremity 24.93 15.39 21 19446 110200 29822811
Chest pain 24.71 15.39 24 19443 117603 29815408
Disturbance in social behaviour 24.54 15.39 14 19453 1457 29931554
Pleurothotonus 23.39 15.39 12 19455 1011 29932000
Analgesic drug level increased 23.01 15.39 10 19457 579 29932432
White blood cell count decreased 22.96 15.39 13 19454 83934 29849077
Accidental death 22.46 15.39 15 19452 2064 29930947
Acute myocardial infarction 21.82 15.39 4 19463 52935 29880076
Cough 21.69 15.39 30 19437 125612 29807399
Apathy 21.00 15.39 23 19444 6209 29926802
Urticaria 20.72 15.39 5 19462 54601 29878410
Pulmonary oedema 20.44 15.39 69 19398 43906 29889105
Cholestasis 20.33 15.39 48 19419 24902 29908109
Eye haematoma 20.31 15.39 5 19462 44 29932967
Hepatitis acute 20.24 15.39 24 19443 7059 29925952
Hepatorenal syndrome 19.91 15.39 15 19452 2496 29930515
Coagulation factor VII level decreased 19.85 15.39 6 19461 120 29932891
Diarrhoea 19.63 15.39 132 19335 333971 29599040
Otospondylomegaepiphyseal dysplasia 19.57 15.39 6 19461 126 29932885
Dyspnoea 19.42 15.39 132 19335 333163 29599848
Metabolic acidosis 19.41 15.39 61 19406 37400 29895611
Dyskinesia 18.88 15.39 43 19424 21791 29911220
Congestive hepatopathy 18.82 15.39 13 19454 1891 29931120
Serotonin syndrome 18.65 15.39 38 19429 17853 29915158
Priapism 18.64 15.39 19 19448 4724 29928287
Disease progression 18.33 15.39 15 19452 79859 29853152
Mixed liver injury 18.28 15.39 13 19454 1980 29931031
Plasma cell myeloma 18.23 15.39 6 19461 53456 29879555
Poisoning 18.03 15.39 29 19438 11353 29921658
Neuropathy peripheral 17.76 15.39 12 19455 70463 29862548
Cerebrovascular accident 17.56 15.39 17 19450 83460 29849551
Toxic epidermal necrolysis 17.40 15.39 37 19430 17903 29915108
Peripheral swelling 17.36 15.39 9 19458 61065 29871946
Sepsis 17.28 15.39 44 19423 146351 29786660
Myoclonus 17.23 15.39 31 19436 13281 29919730
Prescription form tampering 16.95 15.39 8 19459 562 29932449
Rash 16.80 15.39 66 19401 191823 29741188
Tonic convulsion 16.64 15.39 9 19458 844 29932167
Post-injection delirium sedation syndrome 16.43 15.39 7 19460 386 29932625
Lactic acidosis 16.33 15.39 51 19416 31162 29901849
Prothrombin time shortened 16.27 15.39 11 19456 1544 29931467
Brain injury 16.19 15.39 19 19448 5529 29927482
Psychomotor skills impaired 16.09 15.39 12 19455 1967 29931044
Muscle rigidity 16.06 15.39 26 19441 10235 29922776
Retrognathia 16.06 15.39 6 19461 234 29932777
Drug diversion 16.04 15.39 9 19458 907 29932104
Psoriasis 15.91 15.39 4 19463 42502 29890509
Acute respiratory distress syndrome 15.81 15.39 42 19425 23430 29909581
Spinal cord injury thoracic 15.80 15.39 5 19462 117 29932894
Type III immune complex mediated reaction 15.77 15.39 6 19461 246 29932765
Vasoplegia syndrome 15.77 15.39 10 19457 1261 29931750
Bradycardia 15.69 15.39 84 19383 65442 29867569
Judgement impaired 15.58 15.39 8 19459 675 29932336
Acute kidney injury 15.57 15.39 257 19210 273585 29659426
Renal haemorrhage 15.45 15.39 10 19457 1305 29931706

Pharmacologic Action:

SourceCodeDescription
ATC N05BA04 NERVOUS SYSTEM
PSYCHOLEPTICS
ANXIOLYTICS
Benzodiazepine derivatives
FDA CS M0002356 Benzodiazepines
FDA EPC N0000175694 Benzodiazepine
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018682 GABA Agents
MeSH PA D018757 GABA Modulators
MeSH PA D006993 Hypnotics and Sedatives
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents
CHEBI has role CHEBI:35474 minor tranquilisers
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Alcohol withdrawal delirium indication 8635005
Anxiety indication 48694002
Suicidal thoughts contraindication 6471006
Disorder of lung contraindication 19829001 DOID:850
Borderline personality disorder contraindication 20010003 DOID:10930
Alcohol intoxication contraindication 25702006
Shock contraindication 27942005
Depressive disorder contraindication 35489007
Low blood pressure contraindication 45007003
Substance abuse contraindication 66214007
Psychotic disorder contraindication 69322001
Sleep apnea contraindication 73430006 DOID:0050847
Decreased respiratory function contraindication 80954004
Kidney disease contraindication 90708001 DOID:557
Hypoalbuminemia contraindication 119247004
Disease of liver contraindication 235856003 DOID:409
Sleep automatism contraindication 247962006
Syncope contraindication 271594007
Pregnancy, function contraindication 289908002
Coma contraindication 371632003
Porphyria contraindication 418470004
Behavioral Disorders contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.41 acidic
pKa2 11.87 acidic
pKa3 1.83 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor alpha-1/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR IC50 7.75 WOMBAT-PK CHEMBL

External reference:

IDSource
4018020 VUID
N0000146364 NUI
D00464 KEGG_DRUG
4018020 VANDF
C0029997 UMLSCUI
CHEBI:7823 CHEBI
CHEMBL568 ChEMBL_ID
D010076 MESH_DESCRIPTOR_UI
DB00842 DRUGBANK_ID
4616 PUBCHEM_CID
7253 IUPHAR_LIGAND_ID
1507 INN_ID
6GOW6DWN2A UNII
7781 RXNORM
4493 MMSL
5211 MMSL
d00040 MMSL
001462 NDDF
387455006 SNOMEDCT_US
79225003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2067 CAPSULE, GELATIN COATED 10 mg ORAL ANDA 21 sections
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2069 CAPSULE, GELATIN COATED 15 mg ORAL ANDA 21 sections
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 0228-2073 CAPSULE, GELATIN COATED 30 mg ORAL ANDA 21 sections
OXAZEPAM HUMAN PRESCRIPTION DRUG LABEL 1 16590-304 CAPSULE 15 mg ORAL ANDA 13 sections
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 43353-074 CAPSULE, GELATIN COATED 30 mg ORAL ANDA 19 sections
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 43353-965 CAPSULE 10 mg ORAL ANDA 20 sections
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 43353-980 CAPSULE 30 mg ORAL ANDA 20 sections
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 52817-290 CAPSULE 10 mg ORAL ANDA 20 sections
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 52817-291 CAPSULE 15 mg ORAL ANDA 20 sections
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 52817-292 CAPSULE 30 mg ORAL ANDA 20 sections
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 62584-812 CAPSULE, GELATIN COATED 10 mg ORAL ANDA 21 sections
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 62584-813 CAPSULE, GELATIN COATED 15 mg ORAL ANDA 21 sections
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 62584-814 CAPSULE, GELATIN COATED 30 mg ORAL ANDA 21 sections
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 67544-117 CAPSULE, GELATIN COATED 10 mg ORAL ANDA 19 sections
Oxazepam HUMAN PRESCRIPTION DRUG LABEL 1 67544-268 CAPSULE, GELATIN COATED 15 mg ORAL ANDA 19 sections