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ouabain 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2004 | 630-60-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like DIGITALIS. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-EXCHANGING ATPASE.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.25 | mg | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.59 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 1 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,CAMK2D,CDK5,EIF2AK3,GRK2,ITK,MAP2K6,MAP3K21,MAPK10,NTRK2,PDK1,PDK2,PDK4,PRKDC,TEK | 15 | |||
| kinase-selectivity-class | CHUK,MAP2K6,PDK1 | 3 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 1, 1865 | YEAR INTRODUCED |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C01AC01 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY CARDIAC GLYCOSIDES Strophanthus glycosides |
| MeSH PA | D002316 | Cardiotonic Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D020011 | Protective Agents |
| CHEBI has role | CHEBI:38070 | anti-arrhythmia drug |
| CHEBI has role | CHEBI:38147 | cardiotonic drug |
| CHEBI has role | CHEBI:49200 | EC 3.6.3.10 (<em>H</em><small><sup>+</small></sup>/<em>K</em><small><sup>+</small></sup>-exchanging ATPase) inhibitor |
| CHEBI has role | CHEBI:50184 | ion transport inhibitor |
| CHEBI has role | CHEBI:63510 | EC 3.6.3.9 (<em>Na</em><small><sup>+</small></sup>/<em>K</em><small><sup>+</small></sup>-transporting ATPase) inhibitor |
| CHEBI has role | CHEBI:76924 | plant metabolite |
| CHEBI has role | CHEBI:77023 | EC 2.3.3.1 [citrate (<em>Si</em>)-synthase] inhibitor |
| CHEBI has role | CHEBI:77024 | EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor |
Related Drugs by ATC class:
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.77 | acidic |
| pKa2 | 13.57 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 5.01 | WOMBAT-PK | |||||
| Sodium/potassium-transporting ATPase subunit alpha-1 | Transporter | WOMBAT-PK | |||||||
| Signal transducer and activator of transcription 3 | Transcription factor | IC50 | 5.94 | CHEMBL | |||||
| Sodium/potassium-transporting ATPase subunit alpha-2 | Ion channel | IC50 | 6.17 | DRUG MATRIX |
External reference:
| ID | Source |
|---|---|
| N0000168453 | NUI |
| D00112 | KEGG_DRUG |
| C0029904 | UMLSCUI |
| CHEBI:472805 | CHEBI |
| OBN | PDB_CHEM_ID |
| CHEMBL222863 | ChEMBL_ID |
| CHEMBL1889436 | ChEMBL_ID |
| D010042 | MESH_DESCRIPTOR_UI |
| DB01092 | DRUGBANK_ID |
| 4826 | IUPHAR_LIGAND_ID |
| C017899 | MESH_SUPPLEMENTAL_RECORD_UI |
| 5ACL011P69 | UNII |
| 439501 | PUBCHEM_CID |
| 7762 | RXNORM |
| 000597 | NDDF |
| 317914009 | SNOMEDCT_US |
| 35966009 | SNOMEDCT_US |
| 5ACL011P69 | INXIGHT DRUGS |
Pharmaceutical products:
None