oteracil 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
uracil type antineoplastics 2002 937-13-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • potassium oxonate
  • oxonic acid potassium salt
  • oteracil
  • 5-Azaorotic acid
  • oxonic acid
  • oteracil potassium
Antagonist of urate oxidase.
  • Molecular weight: 157.09
  • Formula: C4H3N3O4
  • CLOGP: -2.13
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 107.86
  • ALOGS: -1.34
  • ROTB: 1

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
March 14, 2011 EMA Nordic Group BV

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Malignant tumor of stomach indication 363349007 DOID:10534




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.67 acidic
pKa2 10.06 acidic
pKa3 0.5 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Uridine 5'-monophosphate synthase Enzyme INHIBITOR SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
2207-75-2 SECONDARY_CAS_RN
C0030032 UMLSCUI
CHEBI:80230 CHEBI
OXC PDB_CHEM_ID
CHEMBL181932 ChEMBL_ID
DB03209 DRUGBANK_ID
4604 PUBCHEM_CID
7729 INN_ID
C489337 MESH_SUPPLEMENTAL_RECORD_UI
5VT6420TIG UNII
013265 NDDF
015260 NDDF
D010094 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None