opipramol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
substances of the imipramine group 1993 315-72-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • opipramol dihydrochloride
  • opipramol
  • opramidol
A tricyclic antidepressant with actions similar to AMITRIPTYLINE.
  • Molecular weight: 363.51
  • Formula: C23H29N3O
  • CLOGP: 3.79
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 29.95
  • ALOGS: -3.54
  • ROTB: 6

Drug dosage:

DoseUnitRoute
0.15 g O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC N06AA05 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Non-selective monoamine reuptake inhibitors
MeSH PA D018663 Adrenergic Agents
MeSH PA D018759 Adrenergic Uptake Inhibitors
MeSH PA D000928 Antidepressive Agents
MeSH PA D000929 Antidepressive Agents, Tricyclic
MeSH PA D002491 Central Nervous System Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D011619 Psychotropic Drugs

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Depressive disorder indication 35489007

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.21 Basic
pKa2 5.43 Basic
pKa3 4.21 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase Enzyme Ki 7.89 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 9.70 CHEMBL
C-8 sterol isomerase Enzyme Ki 7.77 CHEMBL

External reference:

IDSource
N0000167254 NUI
C0029105 UMLSCUI
D08297 KEGG_DRUG
7674 RXNORM
004149 NDDF
D23ZXO613C UNII
1838 INN_ID
CHEMBL370753 ChEMBL_ID
CHEBI:94614 CHEBI
D009888 MESH_DESCRIPTOR_UI
DB12930 DRUGBANK_ID
9417 PUBCHEM_CID

Pharmaceutical products:

None