Stem definition | Drug id | CAS RN |
---|---|---|
antibiotics, 6-aminopenicillanic acid derivatives | 198 | 69-53-4 |
Dose | Unit | Route |
---|---|---|
2 | g | O |
6 | g | P |
2 | g | R |
6 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 50 mg/mL | Bocci G, Oprea TI, Benet LZ |
EoM (Fraction excreted unchanged in urine) | 88 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 166.85 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 62 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.22 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 2.80 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.85 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1.40 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 17, 1965 | FDA | WYETH AYERST |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Premature delivery | 697.12 | 16.35 | 248 | 11642 | 30033 | 63447099 |
Normal labour | 437.61 | 16.35 | 77 | 11813 | 440 | 63476692 |
Maternal exposure during pregnancy | 416.09 | 16.35 | 337 | 11553 | 219725 | 63257407 |
Delivery | 378.02 | 16.35 | 80 | 11810 | 1323 | 63475809 |
Drug hypersensitivity | 323.57 | 16.35 | 341 | 11549 | 310346 | 63166786 |
Type IV hypersensitivity reaction | 266.06 | 16.35 | 69 | 11821 | 2829 | 63474303 |
Cross sensitivity reaction | 230.49 | 16.35 | 58 | 11832 | 2104 | 63475028 |
Premature baby | 203.40 | 16.35 | 92 | 11798 | 20643 | 63456489 |
Foetal exposure during pregnancy | 187.94 | 16.35 | 100 | 11790 | 31862 | 63445270 |
Exposure during pregnancy | 154.55 | 16.35 | 167 | 11723 | 155380 | 63321752 |
Low birth weight baby | 128.97 | 16.35 | 49 | 11841 | 7080 | 63470052 |
Rash maculo-papular | 113.39 | 16.35 | 72 | 11818 | 31824 | 63445308 |
Product use in unapproved indication | 92.64 | 16.35 | 139 | 11751 | 178941 | 63298191 |
Pathogen resistance | 91.17 | 16.35 | 37 | 11853 | 6361 | 63470771 |
Drug reaction with eosinophilia and systemic symptoms | 74.66 | 16.35 | 57 | 11833 | 33779 | 63443353 |
Enterocolitis haemorrhagic | 70.37 | 16.35 | 21 | 11869 | 1445 | 63475687 |
Toxic epidermal necrolysis | 67.91 | 16.35 | 48 | 11842 | 25286 | 63451846 |
Amniotic cavity infection | 60.23 | 16.35 | 18 | 11872 | 1245 | 63475887 |
Respiratory acidosis | 57.09 | 16.35 | 27 | 11863 | 6688 | 63470444 |
Multiple organ dysfunction syndrome | 56.32 | 16.35 | 61 | 11829 | 56691 | 63420441 |
Premature rupture of membranes | 51.62 | 16.35 | 23 | 11867 | 4970 | 63472162 |
Septic shock | 51.59 | 16.35 | 63 | 11827 | 66566 | 63410566 |
Intraventricular haemorrhage | 51.06 | 16.35 | 18 | 11872 | 2102 | 63475030 |
Jarisch-Herxheimer reaction | 49.70 | 16.35 | 12 | 11878 | 365 | 63476767 |
Caesarean section | 49.69 | 16.35 | 34 | 11856 | 16998 | 63460134 |
Neonatal disorder | 49.25 | 16.35 | 13 | 11877 | 570 | 63476562 |
Stillbirth | 47.93 | 16.35 | 24 | 11866 | 6726 | 63470406 |
Premature labour | 46.35 | 16.35 | 29 | 11861 | 12475 | 63464657 |
Patent ductus arteriosus | 45.29 | 16.35 | 20 | 11870 | 4230 | 63472902 |
Systemic candida | 43.61 | 16.35 | 18 | 11872 | 3227 | 63473905 |
Appetite disorder | 43.25 | 16.35 | 23 | 11867 | 7298 | 63469834 |
Oedema | 42.37 | 16.35 | 70 | 11820 | 97552 | 63379580 |
Umbilical erythema | 42.26 | 16.35 | 8 | 11882 | 72 | 63477060 |
Thymus disorder | 41.85 | 16.35 | 10 | 11880 | 291 | 63476841 |
Enterococcal infection | 41.75 | 16.35 | 23 | 11867 | 7825 | 63469307 |
Intraventricular haemorrhage neonatal | 41.27 | 16.35 | 9 | 11881 | 172 | 63476960 |
Neonatal respiratory distress syndrome | 39.13 | 16.35 | 16 | 11874 | 2802 | 63474330 |
Candida infection | 38.25 | 16.35 | 36 | 11854 | 28315 | 63448817 |
Pseudomembranous colitis | 37.59 | 16.35 | 16 | 11874 | 3096 | 63474036 |
Sepsis neonatal | 37.29 | 16.35 | 10 | 11880 | 466 | 63476666 |
Laryngeal stenosis | 37.23 | 16.35 | 12 | 11878 | 1066 | 63476066 |
Neonatal respiratory failure | 36.96 | 16.35 | 9 | 11881 | 284 | 63476848 |
Long QT syndrome congenital | 34.15 | 16.35 | 7 | 11883 | 98 | 63477034 |
Hepatic infarction | 33.77 | 16.35 | 10 | 11880 | 670 | 63476462 |
Alopecia | 33.09 | 16.35 | 11 | 11879 | 337525 | 63139607 |
Pulmonary haemorrhage | 32.67 | 16.35 | 19 | 11871 | 7162 | 63469970 |
Perinatal stroke | 32.43 | 16.35 | 5 | 11885 | 10 | 63477122 |
Clostridial infection | 32.32 | 16.35 | 16 | 11874 | 4376 | 63472756 |
Liver abscess | 32.26 | 16.35 | 14 | 11876 | 2840 | 63474292 |
Anaphylactic reaction | 32.24 | 16.35 | 50 | 11840 | 66050 | 63411082 |
Klebsiella infection | 32.08 | 16.35 | 20 | 11870 | 8546 | 63468586 |
Acute respiratory distress syndrome | 31.97 | 16.35 | 30 | 11860 | 23504 | 63453628 |
Death neonatal | 30.22 | 16.35 | 10 | 11880 | 965 | 63476167 |
Arthralgia | 29.66 | 16.35 | 38 | 11852 | 569672 | 62907460 |
Guillain-Barre syndrome | 28.11 | 16.35 | 14 | 11876 | 3879 | 63473253 |
Premature separation of placenta | 27.33 | 16.35 | 11 | 11879 | 1850 | 63475282 |
Maternal drugs affecting foetus | 26.89 | 16.35 | 15 | 11875 | 5227 | 63471905 |
Culture stool positive | 26.79 | 16.35 | 7 | 11883 | 295 | 63476837 |
Joint swelling | 26.77 | 16.35 | 14 | 11876 | 327652 | 63149480 |
Monocytosis | 26.76 | 16.35 | 8 | 11882 | 554 | 63476578 |
Ventricular septal defect | 26.55 | 16.35 | 14 | 11876 | 4364 | 63472768 |
Bradycardia neonatal | 26.48 | 16.35 | 9 | 11881 | 943 | 63476189 |
Hydrops foetalis | 26.13 | 16.35 | 8 | 11882 | 600 | 63476532 |
Neonatal infection | 26.10 | 16.35 | 6 | 11884 | 147 | 63476985 |
Ventricular dysfunction | 25.98 | 16.35 | 12 | 11878 | 2816 | 63474316 |
Fatigue | 25.92 | 16.35 | 83 | 11807 | 887945 | 62589187 |
Foetal heart rate decreased | 25.87 | 16.35 | 6 | 11884 | 153 | 63476979 |
Clostridium difficile colitis | 25.63 | 16.35 | 25 | 11865 | 20544 | 63456588 |
Hepatic function abnormal | 25.36 | 16.35 | 33 | 11857 | 37109 | 63440023 |
Polyhydramnios | 25.21 | 16.35 | 11 | 11879 | 2260 | 63474872 |
Dysphoria | 24.90 | 16.35 | 14 | 11876 | 4952 | 63472180 |
Hydrocephalus | 24.05 | 16.35 | 14 | 11876 | 5286 | 63471846 |
Arthritis infective | 23.94 | 16.35 | 15 | 11875 | 6463 | 63470669 |
Systemic lupus erythematosus | 23.89 | 16.35 | 5 | 11885 | 208913 | 63268219 |
Peripheral swelling | 23.82 | 16.35 | 10 | 11880 | 265932 | 63211200 |
Haemorrhagic diathesis | 23.65 | 16.35 | 13 | 11877 | 4402 | 63472730 |
Hypotonia | 23.51 | 16.35 | 17 | 11873 | 9268 | 63467864 |
Malaise | 23.48 | 16.35 | 26 | 11864 | 415928 | 63061204 |
Bradypnoea | 23.39 | 16.35 | 12 | 11878 | 3538 | 63473594 |
Glossodynia | 23.30 | 16.35 | 3 | 11887 | 178873 | 63298259 |
Atelectasis neonatal | 23.17 | 16.35 | 4 | 11886 | 20 | 63477112 |
Selective eating disorder | 22.88 | 16.35 | 10 | 11880 | 2062 | 63475070 |
Generalised anxiety disorder | 22.88 | 16.35 | 10 | 11880 | 2064 | 63475068 |
Thrombocytopenia neonatal | 22.85 | 16.35 | 4 | 11886 | 22 | 63477110 |
Escherichia infection | 22.80 | 16.35 | 19 | 11871 | 12735 | 63464397 |
Maternal exposure during delivery | 22.49 | 16.35 | 9 | 11881 | 1491 | 63475641 |
Immune reconstitution inflammatory syndrome | 22.27 | 16.35 | 14 | 11876 | 6070 | 63471062 |
Abdominal discomfort | 21.71 | 16.35 | 17 | 11873 | 320868 | 63156264 |
Disseminated intravascular coagulation | 21.60 | 16.35 | 22 | 11868 | 19029 | 63458103 |
Endocarditis candida | 20.66 | 16.35 | 4 | 11886 | 41 | 63477091 |
Atrial septal defect | 20.59 | 16.35 | 14 | 11876 | 6924 | 63470208 |
Hypotonia neonatal | 20.51 | 16.35 | 8 | 11882 | 1238 | 63475894 |
Normal newborn | 20.50 | 16.35 | 15 | 11875 | 8326 | 63468806 |
Neonatal respiratory distress | 20.45 | 16.35 | 6 | 11884 | 389 | 63476743 |
Stevens-Johnson syndrome | 19.96 | 16.35 | 24 | 11866 | 24926 | 63452206 |
Stenotrophomonas infection | 19.88 | 16.35 | 9 | 11881 | 2018 | 63475114 |
Preterm premature rupture of membranes | 19.56 | 16.35 | 8 | 11882 | 1401 | 63475731 |
Pain in extremity | 19.50 | 16.35 | 20 | 11870 | 331466 | 63145666 |
Umbilical cord around neck | 19.48 | 16.35 | 5 | 11885 | 196 | 63476936 |
Oliguria | 19.33 | 16.35 | 15 | 11875 | 9086 | 63468046 |
Necrotising enterocolitis neonatal | 19.15 | 16.35 | 5 | 11885 | 210 | 63476922 |
Enterobacter infection | 19.07 | 16.35 | 9 | 11881 | 2218 | 63474914 |
Circulatory collapse | 19.04 | 16.35 | 22 | 11868 | 21916 | 63455216 |
Pain | 19.03 | 16.35 | 73 | 11817 | 740555 | 62736577 |
Apnoea | 18.76 | 16.35 | 14 | 11876 | 8008 | 63469124 |
Treatment failure | 18.61 | 16.35 | 7 | 11883 | 199036 | 63278096 |
Headache | 18.55 | 16.35 | 59 | 11831 | 633182 | 62843950 |
Infantile apnoea | 18.32 | 16.35 | 7 | 11883 | 1026 | 63476106 |
Congenital lymphoedema | 17.92 | 16.35 | 3 | 11887 | 12 | 63477120 |
Exposure to SARS-CoV-2 | 17.89 | 16.35 | 8 | 11882 | 1743 | 63475389 |
Insomnia | 17.86 | 16.35 | 9 | 11881 | 215243 | 63261889 |
Live birth | 17.85 | 16.35 | 23 | 11867 | 25607 | 63451525 |
Cervical incompetence | 17.82 | 16.35 | 6 | 11884 | 611 | 63476521 |
Nasopharyngitis | 17.79 | 16.35 | 13 | 11877 | 254244 | 63222888 |
Hepatomegaly | 17.79 | 16.35 | 16 | 11874 | 11873 | 63465259 |
Sepsis | 17.75 | 16.35 | 66 | 11824 | 153057 | 63324075 |
Neuromuscular blockade | 17.53 | 16.35 | 5 | 11885 | 293 | 63476839 |
Meconium in amniotic fluid | 17.52 | 16.35 | 5 | 11885 | 294 | 63476838 |
Neonatal cardiac failure | 17.38 | 16.35 | 3 | 11887 | 15 | 63477117 |
Megacolon | 17.20 | 16.35 | 8 | 11882 | 1907 | 63475225 |
Oligohydramnios | 16.91 | 16.35 | 12 | 11878 | 6354 | 63470778 |
Foetal death | 16.87 | 16.35 | 15 | 11875 | 10965 | 63466167 |
Retained placenta or membranes | 16.81 | 16.35 | 5 | 11885 | 340 | 63476792 |
Acute generalised exanthematous pustulosis | 16.73 | 16.35 | 15 | 11875 | 11084 | 63466048 |
Drug resistance | 16.64 | 16.35 | 21 | 11869 | 22912 | 63454220 |
Sinusitis | 16.64 | 16.35 | 11 | 11879 | 226642 | 63250490 |
Perineal necrosis | 16.53 | 16.35 | 4 | 11886 | 123 | 63477009 |
Sweat test abnormal | 16.52 | 16.35 | 3 | 11887 | 21 | 63477111 |
Renal failure | 16.48 | 16.35 | 54 | 11836 | 117598 | 63359534 |
Rheumatoid arthritis | 16.47 | 16.35 | 14 | 11876 | 253805 | 63223327 |
Urine output decreased | 16.42 | 16.35 | 15 | 11875 | 11355 | 63465777 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Premature baby | 185.27 | 16.07 | 94 | 9006 | 19539 | 34928292 |
Foetal exposure during pregnancy | 134.53 | 16.07 | 97 | 9003 | 38004 | 34909827 |
Low birth weight baby | 92.91 | 16.07 | 44 | 9056 | 7861 | 34939970 |
Sepsis neonatal | 87.07 | 16.07 | 19 | 9081 | 257 | 34947574 |
Neonatal disorder | 75.35 | 16.07 | 21 | 9079 | 809 | 34947022 |
Drug hypersensitivity | 68.31 | 16.07 | 94 | 9006 | 80435 | 34867396 |
Red blood cell hyperchromic morphology | 65.62 | 16.07 | 10 | 9090 | 10 | 34947821 |
Type IV hypersensitivity reaction | 56.06 | 16.07 | 19 | 9081 | 1415 | 34946416 |
Cardiac septal defect | 52.79 | 16.07 | 13 | 9087 | 306 | 34947525 |
Pleocytosis | 50.26 | 16.07 | 14 | 9086 | 538 | 34947293 |
Neonatal respiratory distress syndrome | 49.07 | 16.07 | 23 | 9077 | 4011 | 34943820 |
Fatigue | 45.34 | 16.07 | 20 | 9080 | 370633 | 34577198 |
Pulmonary haemorrhage | 45.16 | 16.07 | 30 | 9070 | 10274 | 34937557 |
Pathogen resistance | 44.96 | 16.07 | 29 | 9071 | 9453 | 34938378 |
Kidney duplex | 44.84 | 16.07 | 12 | 9088 | 396 | 34947435 |
Intraventricular haemorrhage | 42.54 | 16.07 | 20 | 9080 | 3511 | 34944320 |
Anisocytosis | 38.64 | 16.07 | 11 | 9089 | 458 | 34947373 |
Intraventricular haemorrhage neonatal | 38.19 | 16.07 | 10 | 9090 | 303 | 34947528 |
Drug ineffective | 38.04 | 16.07 | 225 | 8875 | 456526 | 34491305 |
Necrotising colitis | 37.04 | 16.07 | 13 | 9087 | 1075 | 34946756 |
Neonatal respiratory failure | 36.58 | 16.07 | 10 | 9090 | 358 | 34947473 |
Drug resistance | 36.22 | 16.07 | 39 | 9061 | 25888 | 34921943 |
Congenital cystic lung | 36.03 | 16.07 | 9 | 9091 | 225 | 34947606 |
Systemic candida | 35.56 | 16.07 | 18 | 9082 | 3708 | 34944123 |
Brain abscess | 35.50 | 16.07 | 17 | 9083 | 3108 | 34944723 |
Patent ductus arteriosus | 34.36 | 16.07 | 17 | 9083 | 3337 | 34944494 |
Pyrexia | 34.34 | 16.07 | 174 | 8926 | 332839 | 34614992 |
Death | 34.31 | 16.07 | 32 | 9068 | 398017 | 34549814 |
Listeriosis | 33.80 | 16.07 | 12 | 9088 | 1026 | 34946805 |
Meningitis aseptic | 32.02 | 16.07 | 16 | 9084 | 3208 | 34944623 |
Leukocytosis | 31.53 | 16.07 | 35 | 9065 | 24030 | 34923801 |
Macrocytosis | 30.51 | 16.07 | 11 | 9089 | 983 | 34946848 |
Cross sensitivity reaction | 30.33 | 16.07 | 12 | 9088 | 1385 | 34946446 |
Nutritional condition abnormal | 30.30 | 16.07 | 9 | 9091 | 436 | 34947395 |
Drug withdrawal syndrome neonatal | 30.27 | 16.07 | 16 | 9084 | 3603 | 34944228 |
Janeway lesion | 29.10 | 16.07 | 5 | 9095 | 16 | 34947815 |
Candida infection | 28.97 | 16.07 | 29 | 9071 | 17686 | 34930145 |
Nocardiosis | 28.95 | 16.07 | 16 | 9084 | 3935 | 34943896 |
Congenital skin dimples | 28.25 | 16.07 | 7 | 9093 | 169 | 34947662 |
Hydrops foetalis | 28.14 | 16.07 | 10 | 9090 | 857 | 34946974 |
Death neonatal | 27.63 | 16.07 | 8 | 9092 | 354 | 34947477 |
Type I hypersensitivity | 27.33 | 16.07 | 11 | 9089 | 1328 | 34946503 |
Drug reaction with eosinophilia and systemic symptoms | 27.13 | 16.07 | 38 | 9062 | 32974 | 34914857 |
Bradycardia neonatal | 26.99 | 16.07 | 10 | 9090 | 966 | 34946865 |
Enterocolitis haemorrhagic | 26.92 | 16.07 | 10 | 9090 | 973 | 34946858 |
Polyhydramnios | 25.95 | 16.07 | 7 | 9093 | 238 | 34947593 |
Apnoea | 25.86 | 16.07 | 18 | 9082 | 6646 | 34941185 |
Klebsiella infection | 24.02 | 16.07 | 19 | 9081 | 8512 | 34939319 |
Rash maculo-papular | 23.75 | 16.07 | 33 | 9067 | 28418 | 34919413 |
Acute generalised exanthematous pustulosis | 23.29 | 16.07 | 17 | 9083 | 6759 | 34941072 |
Neonatal candida infection | 23.23 | 16.07 | 4 | 9096 | 13 | 34947818 |
Fall | 23.12 | 16.07 | 12 | 9088 | 202873 | 34744958 |
Fungal skin infection | 23.04 | 16.07 | 12 | 9088 | 2622 | 34945209 |
Eosinophilia | 22.77 | 16.07 | 31 | 9069 | 26191 | 34921640 |
Respiratory failure | 22.76 | 16.07 | 71 | 9029 | 108501 | 34839330 |
Strongyloidiasis | 22.71 | 16.07 | 12 | 9088 | 2699 | 34945132 |
Respiratory distress | 22.11 | 16.07 | 36 | 9064 | 35629 | 34912202 |
Pseudo-Bartter syndrome | 21.69 | 16.07 | 4 | 9096 | 21 | 34947810 |
Pulmonary physical examination abnormal | 21.24 | 16.07 | 4 | 9096 | 24 | 34947807 |
Exposure during pregnancy | 21.17 | 16.07 | 18 | 9082 | 8916 | 34938915 |
Disseminated intravascular coagulation | 20.80 | 16.07 | 27 | 9073 | 21789 | 34926042 |
Lymphocytosis | 20.45 | 16.07 | 11 | 9089 | 2566 | 34945265 |
Posthaemorrhagic hydrocephalus | 20.17 | 16.07 | 5 | 9095 | 121 | 34947710 |
Atrial septal defect | 19.82 | 16.07 | 16 | 9084 | 7376 | 34940455 |
Bronchopulmonary dysplasia | 19.80 | 16.07 | 7 | 9093 | 591 | 34947240 |
Aspartate aminotransferase increased | 19.78 | 16.07 | 50 | 9050 | 67733 | 34880098 |
Grey syndrome neonatal | 19.68 | 16.07 | 3 | 9097 | 3 | 34947828 |
Congenital syphilis | 19.68 | 16.07 | 3 | 9097 | 3 | 34947828 |
Endocarditis | 19.41 | 16.07 | 15 | 9085 | 6496 | 34941335 |
Rash | 18.57 | 16.07 | 110 | 8990 | 222642 | 34725189 |
Enterococcal infection | 18.56 | 16.07 | 17 | 9083 | 9289 | 34938542 |
Maternal drugs affecting foetus | 18.48 | 16.07 | 12 | 9088 | 3953 | 34943878 |
Trichosporon infection | 18.40 | 16.07 | 7 | 9093 | 727 | 34947104 |
Neonatal hypoxia | 18.33 | 16.07 | 6 | 9094 | 401 | 34947430 |
Hepatotoxicity | 18.05 | 16.07 | 25 | 9075 | 21460 | 34926371 |
Dry gangrene | 17.88 | 16.07 | 6 | 9094 | 433 | 34947398 |
Sepsis | 17.76 | 16.07 | 88 | 9012 | 166473 | 34781358 |
Hepatic function abnormal | 17.67 | 16.07 | 37 | 9063 | 44326 | 34903505 |
Candida pneumonia | 17.54 | 16.07 | 6 | 9094 | 459 | 34947372 |
Dizziness | 17.13 | 16.07 | 19 | 9081 | 218502 | 34729329 |
Apgar score low | 17.05 | 16.07 | 7 | 9093 | 888 | 34946943 |
Tubulointerstitial nephritis | 16.97 | 16.07 | 24 | 9076 | 21000 | 34926831 |
Pleural effusion | 16.78 | 16.07 | 53 | 9047 | 81493 | 34866338 |
Photophobia | 16.44 | 16.07 | 14 | 9086 | 6950 | 34940881 |
Mucormycosis | 16.23 | 16.07 | 13 | 9087 | 5929 | 34941902 |
Pseudomonas infection | 16.20 | 16.07 | 18 | 9082 | 12364 | 34935467 |
Microtia | 16.13 | 16.07 | 5 | 9095 | 280 | 34947551 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Type IV hypersensitivity reaction | 337.81 | 14.09 | 89 | 14451 | 3992 | 79725856 |
Cross sensitivity reaction | 255.56 | 14.09 | 70 | 14470 | 3642 | 79726206 |
Drug hypersensitivity | 223.03 | 14.09 | 273 | 14267 | 298643 | 79431205 |
Premature delivery | 167.60 | 14.09 | 83 | 14457 | 23384 | 79706464 |
Exposure during pregnancy | 166.84 | 14.09 | 142 | 14398 | 100990 | 79628858 |
Rash maculo-papular | 143.13 | 14.09 | 102 | 14438 | 55976 | 79673872 |
Maternal exposure during pregnancy | 125.40 | 14.09 | 139 | 14401 | 136399 | 79593449 |
Pathogen resistance | 118.30 | 14.09 | 56 | 14484 | 14286 | 79715562 |
Drug reaction with eosinophilia and systemic symptoms | 109.55 | 14.09 | 92 | 14448 | 64152 | 79665696 |
Enterocolitis haemorrhagic | 95.65 | 14.09 | 29 | 14511 | 2165 | 79727683 |
Toxic epidermal necrolysis | 64.19 | 14.09 | 58 | 14482 | 44523 | 79685325 |
Amniotic cavity infection | 63.49 | 14.09 | 17 | 14523 | 810 | 79729038 |
Enterococcal infection | 63.26 | 14.09 | 38 | 14502 | 15622 | 79714226 |
Drug ineffective | 56.14 | 14.09 | 362 | 14178 | 1080551 | 78649297 |
Anaphylactic reaction | 55.04 | 14.09 | 72 | 14468 | 83671 | 79646177 |
Septic shock | 50.92 | 14.09 | 85 | 14455 | 122716 | 79607132 |
Pyrexia | 50.10 | 14.09 | 250 | 14290 | 678459 | 79051389 |
Pleocytosis | 45.96 | 14.09 | 15 | 14525 | 1424 | 79728424 |
Klebsiella infection | 45.70 | 14.09 | 31 | 14509 | 15689 | 79714159 |
Oedema | 44.62 | 14.09 | 79 | 14461 | 119501 | 79610347 |
Premature labour | 43.62 | 14.09 | 24 | 14516 | 8366 | 79721482 |
Premature rupture of membranes | 43.37 | 14.09 | 19 | 14521 | 4050 | 79725798 |
Thymus disorder | 42.24 | 14.09 | 10 | 14530 | 287 | 79729561 |
Respiratory acidosis | 42.21 | 14.09 | 26 | 14514 | 11174 | 79718674 |
Caesarean section | 41.98 | 14.09 | 27 | 14513 | 12508 | 79717340 |
Pseudomembranous colitis | 41.31 | 14.09 | 20 | 14520 | 5354 | 79724494 |
Appetite disorder | 39.85 | 14.09 | 22 | 14518 | 7717 | 79722131 |
Listeriosis | 39.40 | 14.09 | 15 | 14525 | 2235 | 79727613 |
Hepatic function abnormal | 39.22 | 14.09 | 57 | 14483 | 73050 | 79656798 |
Arthritis infective | 38.49 | 14.09 | 22 | 14518 | 8249 | 79721599 |
Fatigue | 37.95 | 14.09 | 70 | 14470 | 929657 | 78800191 |
Laryngeal stenosis | 37.43 | 14.09 | 12 | 14528 | 1076 | 79728772 |
Candida infection | 36.91 | 14.09 | 40 | 14500 | 38174 | 79691674 |
Tubulointerstitial nephritis | 36.89 | 14.09 | 40 | 14500 | 38195 | 79691653 |
Multiple organ dysfunction syndrome | 36.82 | 14.09 | 73 | 14467 | 120173 | 79609675 |
Meningitis aseptic | 36.52 | 14.09 | 20 | 14520 | 6908 | 79722940 |
Jarisch-Herxheimer reaction | 34.76 | 14.09 | 11 | 14529 | 946 | 79728902 |
Clostridial infection | 34.34 | 14.09 | 18 | 14522 | 5696 | 79724152 |
Brain abscess | 33.87 | 14.09 | 17 | 14523 | 4919 | 79724929 |
Pseudomonas infection | 33.68 | 14.09 | 29 | 14511 | 20874 | 79708974 |
Clostridium difficile colitis | 33.31 | 14.09 | 35 | 14505 | 32248 | 79697600 |
Drug resistance | 32.02 | 14.09 | 39 | 14501 | 42174 | 79687674 |
Nocardiosis | 31.62 | 14.09 | 17 | 14523 | 5662 | 79724186 |
Long QT syndrome congenital | 31.53 | 14.09 | 7 | 14533 | 150 | 79729698 |
Rash | 31.23 | 14.09 | 196 | 14344 | 578162 | 79151686 |
Hepatic infarction | 31.10 | 14.09 | 10 | 14530 | 905 | 79728943 |
Janeway lesion | 30.88 | 14.09 | 5 | 14535 | 16 | 79729832 |
Drug eruption | 30.77 | 14.09 | 39 | 14501 | 43896 | 79685952 |
Culture stool positive | 30.50 | 14.09 | 9 | 14531 | 612 | 79729236 |
Acute generalised exanthematous pustulosis | 29.98 | 14.09 | 25 | 14515 | 17229 | 79712619 |
Type I hypersensitivity | 29.74 | 14.09 | 15 | 14525 | 4383 | 79725465 |
Leukocytosis | 29.53 | 14.09 | 38 | 14502 | 43417 | 79686431 |
Death | 29.50 | 14.09 | 36 | 14504 | 566478 | 79163370 |
Nutritional condition abnormal | 29.15 | 14.09 | 10 | 14530 | 1107 | 79728741 |
Photophobia | 28.15 | 14.09 | 26 | 14514 | 20502 | 79709346 |
Stevens-Johnson syndrome | 27.80 | 14.09 | 35 | 14505 | 39131 | 79690717 |
Aspartate aminotransferase increased | 27.67 | 14.09 | 71 | 14469 | 138570 | 79591278 |
Renal infarct | 26.86 | 14.09 | 12 | 14528 | 2679 | 79727169 |
Alopecia | 26.57 | 14.09 | 5 | 14535 | 231350 | 79498498 |
Toxicity to various agents | 26.21 | 14.09 | 23 | 14517 | 421517 | 79308331 |
Circulatory collapse | 25.69 | 14.09 | 33 | 14507 | 37635 | 79692213 |
Malaise | 25.63 | 14.09 | 31 | 14509 | 489838 | 79240010 |
Eosinophilia | 25.26 | 14.09 | 36 | 14504 | 45309 | 79684539 |
Haemorrhagic diathesis | 25.18 | 14.09 | 15 | 14525 | 6069 | 79723779 |
Polyhydramnios | 24.94 | 14.09 | 10 | 14530 | 1710 | 79728138 |
Acute respiratory distress syndrome | 24.56 | 14.09 | 35 | 14505 | 44032 | 79685816 |
Premature separation of placenta | 24.34 | 14.09 | 9 | 14531 | 1237 | 79728611 |
Live birth | 24.28 | 14.09 | 23 | 14517 | 18721 | 79711127 |
Respiratory failure | 23.94 | 14.09 | 80 | 14460 | 180831 | 79549017 |
Meningitis | 23.43 | 14.09 | 17 | 14523 | 9565 | 79720283 |
Dysphoria | 23.13 | 14.09 | 13 | 14527 | 4721 | 79725127 |
Normal newborn | 23.10 | 14.09 | 15 | 14525 | 7057 | 79722791 |
Pulmonary physical examination abnormal | 22.66 | 14.09 | 4 | 14536 | 24 | 79729824 |
Strongyloidiasis | 22.63 | 14.09 | 12 | 14528 | 3886 | 79725962 |
Generalised anxiety disorder | 22.58 | 14.09 | 10 | 14530 | 2187 | 79727661 |
Monocytosis | 22.25 | 14.09 | 8 | 14532 | 1016 | 79728832 |
Arthropathy | 22.19 | 14.09 | 3 | 14537 | 177108 | 79552740 |
Anaphylactic shock | 22.17 | 14.09 | 30 | 14510 | 35966 | 79693882 |
Linear IgA disease | 22.11 | 14.09 | 11 | 14529 | 3121 | 79726727 |
Endocarditis | 21.91 | 14.09 | 17 | 14523 | 10580 | 79719268 |
Product dose omission issue | 21.67 | 14.09 | 9 | 14531 | 247528 | 79482320 |
Klebsiella test positive | 21.51 | 14.09 | 9 | 14531 | 1714 | 79728134 |
Erythema | 21.40 | 14.09 | 89 | 14451 | 223201 | 79506647 |
Skin test positive | 21.18 | 14.09 | 8 | 14532 | 1166 | 79728682 |
Oliguria | 21.10 | 14.09 | 20 | 14520 | 16289 | 79713559 |
Peripheral swelling | 20.29 | 14.09 | 12 | 14528 | 269605 | 79460243 |
Maternal exposure during delivery | 20.12 | 14.09 | 8 | 14532 | 1338 | 79728510 |
Arthralgia | 19.93 | 14.09 | 47 | 14493 | 571756 | 79158092 |
Guillain-Barre syndrome | 19.89 | 14.09 | 15 | 14525 | 8950 | 79720898 |
Completed suicide | 19.85 | 14.09 | 10 | 14530 | 245757 | 79484091 |
Stillbirth | 19.70 | 14.09 | 11 | 14529 | 3944 | 79725904 |
Clostridium test positive | 19.41 | 14.09 | 13 | 14527 | 6441 | 79723407 |
Joint swelling | 18.85 | 14.09 | 15 | 14525 | 288631 | 79441217 |
Megacolon | 18.17 | 14.09 | 10 | 14530 | 3485 | 79726363 |
Pleural effusion | 18.12 | 14.09 | 63 | 14477 | 145199 | 79584649 |
Pain in extremity | 18.08 | 14.09 | 24 | 14516 | 364514 | 79365334 |
Hepatotoxicity | 17.95 | 14.09 | 33 | 14507 | 51319 | 79678529 |
Bradypnoea | 17.75 | 14.09 | 12 | 14528 | 6040 | 79723808 |
Preterm premature rupture of membranes | 17.08 | 14.09 | 7 | 14533 | 1266 | 79728582 |
Fall | 17.04 | 14.09 | 40 | 14500 | 487589 | 79242259 |
Exposure to SARS-CoV-2 | 16.91 | 14.09 | 8 | 14532 | 2036 | 79727812 |
Foetal death | 16.84 | 14.09 | 13 | 14527 | 8031 | 79721817 |
Bacteraemia | 16.74 | 14.09 | 25 | 14515 | 32799 | 79697049 |
Umbilical cord prolapse | 16.72 | 14.09 | 3 | 14537 | 20 | 79729828 |
Nephritis | 16.43 | 14.09 | 10 | 14530 | 4204 | 79725644 |
Perineal necrosis | 16.39 | 14.09 | 4 | 14536 | 131 | 79729717 |
Neonatal disorder | 16.36 | 14.09 | 3 | 14537 | 23 | 79729825 |
Sepsis | 16.19 | 14.09 | 94 | 14446 | 269334 | 79460514 |
Paraesthesia | 16.10 | 14.09 | 6 | 14534 | 176317 | 79553531 |
Staphylococcal scalded skin syndrome | 16.05 | 14.09 | 5 | 14535 | 408 | 79729440 |
Uterine contractions abnormal | 16.00 | 14.09 | 4 | 14536 | 145 | 79729703 |
Escherichia infection | 15.91 | 14.09 | 18 | 14522 | 17999 | 79711849 |
Oligohydramnios | 15.67 | 14.09 | 9 | 14531 | 3403 | 79726445 |
Teratoma | 15.52 | 14.09 | 4 | 14536 | 164 | 79729684 |
Angioedema | 15.22 | 14.09 | 39 | 14501 | 75996 | 79653852 |
Encephalitis | 15.22 | 14.09 | 16 | 14524 | 14744 | 79715104 |
Disseminated intravascular coagulation | 15.09 | 14.09 | 25 | 14515 | 35817 | 79694031 |
Alanine aminotransferase increased | 14.94 | 14.09 | 64 | 14476 | 162506 | 79567342 |
Cervical incompetence | 14.86 | 14.09 | 5 | 14535 | 522 | 79729326 |
Sweat test abnormal | 14.85 | 14.09 | 3 | 14537 | 40 | 79729808 |
Depressed level of consciousness | 14.84 | 14.09 | 45 | 14495 | 96607 | 79633241 |
Pain | 14.83 | 14.09 | 72 | 14468 | 703730 | 79026118 |
Meningitis listeria | 14.76 | 14.09 | 6 | 14534 | 1063 | 79728785 |
Renal failure | 14.70 | 14.09 | 74 | 14466 | 200894 | 79528954 |
Injection site pain | 14.49 | 14.09 | 3 | 14537 | 129835 | 79600013 |
Insomnia | 14.48 | 14.09 | 14 | 14526 | 245156 | 79484692 |
Clostridium colitis | 14.42 | 14.09 | 8 | 14532 | 2831 | 79727017 |
Lymphocyte stimulation test positive | 14.42 | 14.09 | 6 | 14534 | 1127 | 79728721 |
Systemic candida | 14.39 | 14.09 | 11 | 14529 | 6695 | 79723153 |
Wound infection fungal | 14.38 | 14.09 | 4 | 14536 | 220 | 79729628 |
Sinusitis | 14.28 | 14.09 | 9 | 14531 | 195492 | 79534356 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Foetal exposure during pregnancy | 51.47 | 19.92 | 34 | 835 | 12807 | 76116 |
Drug ineffective | 45.70 | 19.92 | 53 | 816 | 999 | 87924 |
Abdominal distension | 28.02 | 19.92 | 16 | 853 | 98 | 88825 |
Candida infection | 25.71 | 19.92 | 14 | 855 | 77 | 88846 |
Haematochezia | 23.83 | 19.92 | 9 | 860 | 16 | 88907 |
Intraventricular haemorrhage | 23.40 | 19.92 | 16 | 853 | 140 | 88783 |
Pulmonary haemorrhage | 21.61 | 19.92 | 21 | 848 | 315 | 88608 |
Thrombocytopenia | 20.93 | 19.92 | 12 | 857 | 74 | 88849 |
Source | Code | Description |
---|---|---|
ATC | J01CA01 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE BETA-LACTAM ANTIBACTERIALS, PENICILLINS Penicillins with extended spectrum |
ATC | J01CA51 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE BETA-LACTAM ANTIBACTERIALS, PENICILLINS Penicillins with extended spectrum |
ATC | J01CR01 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE BETA-LACTAM ANTIBACTERIALS, PENICILLINS Combinations of penicillins, incl. beta-lactamase inhibitors |
ATC | S01AA19 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Antibiotics |
FDA CS | M0016152 | Penicillins |
FDA EPC | N0000175497 | Penicillin-class Antibacterial |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
CHEBI has role | CHEBI:36047 | antibacterial drugs |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Acute otitis media | indication | 3110003 | |
Septicemia due to Escherichia coli | indication | 9323009 | |
Bacterial septicemia | indication | 10001005 | DOID:0040085 |
Gonorrhea | indication | 15628003 | DOID:7551 |
Haemophilus Influenzae Acute Otitis Media | indication | 19021002 | |
Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
Acute gonococcal cervicitis | indication | 20943002 | DOID:10615 |
Acute bacterial epiglottitis | indication | 21060003 | |
Staphylococcal pneumonia | indication | 22754005 | |
Streptococcal septicemia | indication | 29577008 | |
Acute epiglottitis | indication | 29608009 | DOID:9398 |
Acute gonococcal urethritis | indication | 29864006 | |
Pneumonia due to Streptococcus | indication | 34020007 | |
Shigellosis | indication | 36188001 | |
Sinusitis | indication | 36971009 | |
Streptococcal tonsillitis | indication | 41582007 | |
Gonorrhea of rectum | indication | 42746002 | |
Salmonella septicemia | indication | 49786009 | |
Pneumococcal meningitis | indication | 51169003 | |
Bacterial pneumonia | indication | 53084003 | DOID:874 |
Acute gonococcal endometritis | indication | 65295003 | DOID:7527 |
Urinary tract infectious disease | indication | 68566005 | |
Haemophilus influenzae pneumonia | indication | 70036007 | |
Infection due to Escherichia coli | indication | 71057007 | |
Rhinoscleroma | indication | 72409005 | DOID:11336 |
Staphylococcal endocarditis | indication | 73028002 | |
Acute bacterial sinusitis | indication | 75498004 | |
Pneumococcal pharyngitis | indication | 76651006 | |
Cholangitis | indication | 82403002 | DOID:9446 |
Paratyphoid fever | indication | 85904008 | DOID:3055 |
Bacterial meningitis | indication | 95883001 | DOID:9470 |
Dysentery | indication | 111939009 | |
Female genital tract infection | indication | 125585007 | |
Infectious disease of abdomen | indication | 128070006 | |
Infection due to Enterobacteriaceae | indication | 128945009 | |
Meningococcal meningitis | indication | 192644005 | |
Escherichia coli meningitis | indication | 192655005 | |
Bacterial peritonitis | indication | 197171003 | |
Pneumococcal pneumonia | indication | 233607000 | |
Proteus septicemia | indication | 300986008 | |
Proteus urinary tract infection | indication | 301012009 | |
Bacterial endocarditis | indication | 301183007 | |
Septicemia due to enterococcus | indication | 310669007 | |
Bacterial urinary infection | indication | 312124009 | |
Infective otitis media | indication | 312218008 | |
Pharyngitis | indication | 405737000 | DOID:2275 |
Infection due to Staphylococcus aureus | indication | 406602003 | |
Acute exacerbation of chronic bronchitis | indication | 425748003 | |
Sepsis due to Staphylococcus aureus | indication | 448417001 | |
Staphylococcus Acute Otitis Media | indication | 703469002 | |
Bacteroides Gynecological Infections | indication | ||
Skin and Skin Structure Acinetobacter Infection | indication | ||
Haemophilus Influenzae Pharyngitis | indication | ||
Skin and Skin Structure Proteus Infection | indication | ||
Cesarean Section Infection Prevention | indication | ||
Streptococcus Pneumoniae Chronic Bronchitis | indication | ||
Haemophilus Influenzae Chronic Bronchitis | indication | ||
Skin and Skin Structure Bacteroides Fragilis Infection | indication | ||
Vaginal Hysterectomy Infection Prevention | indication | ||
Pneumococcal Acute Otitis Media | indication | ||
Staphylococcus Epidermidis Skin and Skin Structure Infection | indication | ||
Streptococcal Endocarditis | indication | ||
Bacteroides Peritonitis | indication | ||
E. Coli Peritonitis | indication | ||
Gastroenteritis due to Salmonella | indication | ||
Enterococcus Urinary Tract Infection | indication | ||
Neonatal Group B Streptococcal Septicemia | indication | ||
Klebsiella Pneumoniae Peritonitis | indication | ||
Genitourinary Tract Infections | indication | ||
Inflammatory Disease of Female Pelvic Organs | indication | ||
Intra-Abdominal E. Coli Abscess | indication | ||
E. Coli Gynecological Infections | indication | ||
Infection Prevention for GI Surgery | indication | ||
Necrotizing enterocolitis in fetus OR newborn | off-label use | 2707005 | |
Listeriosis | off-label use | 4241002 | DOID:11573 |
Streptococcal meningitis | off-label use | 4510004 | DOID:11574 |
Typhoid fever | off-label use | 4834000 | DOID:13258 |
Pyrexia of unknown origin | off-label use | 7520000 | |
Inhalational anthrax | off-label use | 11389007 | |
Listeria meningitis | off-label use | 31568009 | DOID:11572 |
Pseudotuberculosis | off-label use | 36753006 | |
Enterocolitis | off-label use | 43752006 | |
Infection of bone | off-label use | 111253001 | |
Gastrointestinal anthrax | off-label use | 111798006 | DOID:13386 |
Infection by Campylobacter fetus | off-label use | 111835002 | |
Listerial endocarditis | off-label use | 186318004 | |
Sepsis of the newborn | off-label use | 206376005 | |
Neonatal pneumonia | off-label use | 233619008 | |
Human bite - wound | off-label use | 262555007 | |
Diverticulitis of gastrointestinal tract | off-label use | 271366000 | |
Neonatal meningitis | off-label use | 276674008 | |
Dog bite - wound | off-label use | 283734005 | |
Cat bite - wound | off-label use | 283782004 | |
Cutaneous listeriosis | off-label use | 402128003 | |
Anthrax | off-label use | 409498004 | DOID:7427 |
Pharyngitis due to Haemophilus Parainfluenzae | off-label use | ||
Haemophilus Parainfluenzae Chronic Bronchitis | off-label use | ||
Listeria Osteomyelitis | off-label use | ||
Haemophilus Parainfluenzae Acute Otitis Media | off-label use | ||
Diabetic Foot Infection | off-label use | ||
Haemophilus Parainfluenzae Pneumonia | off-label use | ||
H. Influenzae Meningitis | off-label use | ||
Listeria Septic Arthritis | off-label use | ||
Granulomatosis Infantiseptica | off-label use | ||
Listeria Monocytogenes Septicemia | off-label use | ||
Prevention of Neonatal Group B Streptococcal Infection | off-label use | ||
Prevention of Bacterial Endocarditis | off-label use | ||
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Acute nephropathy | contraindication | 58574008 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Anemia due to enzyme deficiency | contraindication | 111577008 | |
Disease of blood AND/OR blood-forming organ | contraindication | 191124002 | DOID:74 |
Impaired renal function disorder | contraindication | 197663003 | |
Infectious mononucleosis | contraindication | 271558008 | DOID:8568 |
Uric acid renal calculus | contraindication | 274401005 | |
Pseudomembranous enterocolitis | contraindication | 397683000 | |
Uric Acid Nephropathy Gout | contraindication |
Species | Use | Relation |
---|---|---|
Cats | Skin, Soft Tissue and Post-Surgical Infections caused by Escherichia coli | Indication |
Cats | Skin, Soft Tissue and Post-Surgical Infections caused by Proteus mirabilis | Indication |
Cats | Skin, Soft Tissue and Post-Surgical Infections caused by hemolytic streptococci | Indication |
Cats | Skin, Soft Tissue and Post-Surgical Infections caused by Staphylococcus spp | Indication |
Cats | Skin, Soft Tissue and Post-Surgical Infections caused by Pasteurella spp | Indication |
Cats | Urinary Tract Infections caused by Proteus mirabilis | Indication |
Cats | Urinary Tract Infections caused by Escherichia coli | Indication |
Cats | Urinary tract infections caused by Staphylococcus species | Indication |
Cats | Urinary Tract Infections caused by hemolytic streptococci | Indication |
Cats | Urinary Tract Infections caused by Enterococcus spp | Indication |
Cats | Upper respiratory infections caused by hemolytic streptococci | Indication |
Cats | Upper respiratory infections caused by Staphylococcus aureus | Indication |
Cats | Upper respiratory infections caused by Escherichia coli | Indication |
Cats | Upper respiratory infections caused by Proteus mirabilis | Indication |
Cats | Upper respiratory infections caused by Pasteurella spp | Indication |
Cats | Gastrointestinal Infections caused by Enterococcus spp | Indication |
Cats | Gastrointestinal Infections caused by Staphylococcus spp | Indication |
Cats | Gastrointestinal Infections caused by Escherichia coli | Indication |
Cats | Tonsillitis caused by Escherichia coli | Indication |
Cats | Tonsillitis caused by hemolytic streptococci | Indication |
Cats | Tonsillitis caused by Pasteurella spp | Indication |
Cats | Tonsillitis caused by Proteus mirabilis | Indication |
Cats | Tonsillitis caused by Staphylococcus aureus | Indication |
Cats | Bronchopneumonia caused by Escherichia coli | Indication |
Cats | Bronchopneumonia caused by hemolytic streptococci | Indication |
Cats | Bronchopneumonia caused by Pasteurella spp | Indication |
Cats | Bronchopneumonia caused by Proteus mirabilis | Indication |
Cats | Bronchopneumonia caused by Staphylococcus aureus | Indication |
Cats | Abscesses caused by hemolytic streptococci | Indication |
Cats | Abscesses caused by Escherichia coli | Indication |
Cats | Abscesses caused by Pasteurella spp | Indication |
Cats | Abscesses caused by Proteus mirabilis | Indication |
Cats | Abscesses caused by Staphylococcus spp | Indication |
Cats | Pustular dermatitis caused by hemolytic streptococci | Indication |
Cats | Pustular dermatitis caused by Escherichia coli | Indication |
Cats | Pustular dermatitis caused by Pasteurella spp | Indication |
Cats | Pustular dermatitis caused by Proteus mirabilis | Indication |
Cats | Pustular dermatitis caused by Staphylococcus spp | Indication |
Cats | Cellulitis caused by hemolytic streptococci | Indication |
Cats | Cellulitis caused by Escherichia coli | Indication |
Cats | Cellulitis caused by Pasteurella spp | Indication |
Cats | Cellulitis caused by Proteus mirabilis | Indication |
Cats | Cellulitis caused by Staphylococcus spp | Indication |
Cats | Infections of the anal gland caused by hemolytic streptococci | Indication |
Cats | Infections of the anal gland caused by Escherichia coli | Indication |
Cats | Infections of the anal gland caused by Pasteurella spp | Indication |
Cats | Infections of the anal gland caused by Proteus mirabilis | Indication |
Cats | Infections of the anal gland caused by Staphylococcus spp | Indication |
Cattle | Bacterial pneumonia caused by Aerobacter spp | Indication |
Cattle | Bacterial pneumonia caused by Klebsiella spp | Indication |
Cattle | Bacterial pneumonia caused by Staphylococcus spp | Indication |
Cattle | Bacterial pneumonia caused by Streptococcus spp | Indication |
Cattle | Bacterial pneumonia caused by Pasteurella multocida | Indication |
Cattle | Bacterial pneumonia caused by Escherichia coli | Indication |
Dogs | Skin, Soft Tissue and Post-Surgical Infections caused by Escherichia coli | Indication |
Dogs | Skin, Soft Tissue and Post-Surgical Infections caused by Proteus mirabilis | Indication |
Dogs | Skin, Soft Tissue and Post-Surgical Infections caused by hemolytic streptococci | Indication |
Dogs | Skin, Soft Tissue and Post-Surgical Infections caused by Staphylococcus spp | Indication |
Dogs | Skin, Soft Tissue and Post-Surgical Infections caused by hemolytic streptococci | Indication |
Dogs | Upper respiratory infections caused by hemolytic streptococci | Indication |
Dogs | Upper respiratory infections caused by Staphylococcus aureus | Indication |
Dogs | Upper respiratory infections caused by Escherichia coli | Indication |
Dogs | Upper respiratory infections caused by Proteus mirabilis | Indication |
Dogs | Upper respiratory infections caused by Pasteurella spp | Indication |
Dogs | Urinary Tract Infections caused by Proteus mirabilis | Indication |
Dogs | Urinary Tract Infections caused by Escherichia coli | Indication |
Dogs | Urinary tract infections caused by Staphylococcus species | Indication |
Dogs | Urinary Tract Infections caused by hemolytic streptococci | Indication |
Dogs | Urinary Tract Infections caused by Enterococcus spp | Indication |
Dogs | Gastrointestinal Infections caused by Enterococcus spp | Indication |
Dogs | Gastrointestinal Infections caused by Staphylococcus spp | Indication |
Dogs | Gastrointestinal Infections caused by Escherichia coli | Indication |
Dogs | Tonsillitis caused by Escherichia coli | Indication |
Dogs | Tonsillitis caused by hemolytic streptococci | Indication |
Dogs | Tonsillitis caused by Pasteurella spp | Indication |
Dogs | Tonsillitis caused by Proteus mirabilis | Indication |
Dogs | Tonsillitis caused by Staphylococcus aureus | Indication |
Dogs | Bronchopneumonia caused by Escherichia coli | Indication |
Dogs | Bronchopneumonia caused by hemolytic streptococci | Indication |
Dogs | Bronchopneumonia caused by Pasteurella spp | Indication |
Dogs | Bronchopneumonia caused by Proteus mirabilis | Indication |
Dogs | Bronchopneumonia caused by Staphylococcus aureus | Indication |
Dogs | Abscesses caused by Staphylococcus spp | Indication |
Dogs | Pustular dermatitis caused by Staphylococcus spp | Indication |
Dogs | Cellulitis caused by Staphylococcus spp | Indication |
Dogs | Infections of the anal gland caused by Staphylococcus spp | Indication |
Dogs | Abscesses caused by hemolytic streptococci | Indication |
Dogs | Abscesses caused by Escherichia coli | Indication |
Dogs | Abscesses caused by hemolytic streptococci | Indication |
Dogs | Abscesses caused by Proteus mirabilis | Indication |
Dogs | Pustular dermatitis caused by hemolytic streptococci | Indication |
Dogs | Pustular dermatitis caused by Escherichia coli | Indication |
Dogs | Pustular dermatitis caused by hemolytic streptococci | Indication |
Dogs | Pustular dermatitis caused by Proteus mirabilis | Indication |
Dogs | Cellulitis caused by hemolytic streptococci | Indication |
Dogs | Cellulitis caused by Escherichia coli | Indication |
Dogs | Cellulitis caused by hemolytic streptococci | Indication |
Dogs | Cellulitis caused by Proteus mirabilis | Indication |
Dogs | Infections of the anal gland caused by hemolytic streptococci | Indication |
Dogs | Infections of the anal gland caused by Escherichia coli | Indication |
Dogs | Infections of the anal gland caused by hemolytic streptococci | Indication |
Dogs | Infections of the anal gland caused by Proteus mirabilis | Indication |
Horses | Respiratory tract infections caused by Staphylococcus species | Indication |
Horses | Respiratory tract infections caused by Escherichia coli | Indication |
Horses | Respiratory tract infections caused by Proteus mirabilis | Indication |
Horses | Skin and soft tissue infections caused by Staphylococcus spp | Indication |
Horses | Skin and soft tissue infections caused by Streptococcus spp | Indication |
Horses | Skin and soft tissue infections caused by Escherichia coli | Indication |
Horses | Skin and soft tissue infections caused by Proteus mirabilis | Indication |
Product | Applicant | Ingredients |
---|---|---|
Omnipen 250 mg | Zoetis Inc. | 1 |
Polyflex | Boehringer lngelheim Animal Health USA Inc. | 1 |
Ampi-Tab | Zoetis Inc. | 1 |
Princillin Injection | Zoetis Inc. | 1 |
Princillin Injection | Zoetis Inc. | 1 |
Princillin Injection 200 mg | Zoetis Inc. | 1 |
Ampi-Bol | Zoetis Inc. | 1 |
Ampi-Ject | Zoetis Inc. | 1 |
Amp-Equine | Zoetis Inc. | 1 |
Ampicillin Trihydrate | HQ Specialty Pharma Corp. | 1 |
Ampicillin Sodium | HQ Specialty Pharma Corp. | 1 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.79 | acidic |
pKa2 | 7.67 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Angiopoietin-1 receptor | Kinase | Kd | 4.09 | CHEMBL | |||||
Transient receptor potential cation channel subfamily M member 4 | Ion channel | IC50 | 4.72 | CHEMBL | |||||
Bacterial penicillin-binding protein | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
Penicillin-binding protein 1A | Enzyme | WOMBAT-PK |
ID | Source |
---|---|
4017545 | VUID |
N0000145927 | NUI |
D01251 | KEGG_DRUG |
69-52-3 | SECONDARY_CAS_RN |
7177-48-2 | SECONDARY_CAS_RN |
203115 | RXNORM |
C0002680 | UMLSCUI |
CHEBI:28971 | CHEBI |
AIC | PDB_CHEM_ID |
CHEMBL174 | ChEMBL_ID |
DB00415 | DRUGBANK_ID |
CHEMBL1200758 | ChEMBL_ID |
CHEMBL453388 | ChEMBL_ID |
D000667 | MESH_DESCRIPTOR_UI |
6249 | PUBCHEM_CID |
10896 | IUPHAR_LIGAND_ID |
1339 | INN_ID |
7C782967RD | UNII |
17720 | MMSL |
3783 | MMSL |
4194 | MMSL |
4195 | MMSL |
71827 | MMSL |
d00003 | MMSL |
1268946000 | SNOMEDCT_US |
31087008 | SNOMEDCT_US |
387170002 | SNOMEDCT_US |
96070009 | SNOMEDCT_US |
96071008 | SNOMEDCT_US |
4017543 | VANDF |
4017544 | VANDF |
4017545 | VANDF |
002692 | NDDF |
002693 | NDDF |
002694 | NDDF |
002695 | NDDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
UNASYN | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0049-0013 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAMUSCULAR | NDA | 26 sections |
UNASYN | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0049-0013 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAMUSCULAR | NDA | 26 sections |
UNASYN | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0049-0014 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAMUSCULAR | NDA | 26 sections |
UNASYN | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0049-0014 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAMUSCULAR | NDA | 26 sections |
UNASYN | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0049-0024 | INJECTION, POWDER, FOR SOLUTION | 100 mg | INTRAMUSCULAR | NDA | 25 sections |
UNASYN | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0049-0024 | INJECTION, POWDER, FOR SOLUTION | 100 mg | INTRAMUSCULAR | NDA | 25 sections |
UNASYN | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0049-0031 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAMUSCULAR | ANDA | 26 sections |
UNASYN | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0049-0031 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAMUSCULAR | ANDA | 26 sections |
UNASYN | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0049-0032 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAMUSCULAR | ANDA | 26 sections |
UNASYN | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0049-0032 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAMUSCULAR | ANDA | 26 sections |
AMPICILLIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9816 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAMUSCULAR | ANDA | 13 sections |
AMPICILLIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9816 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAMUSCULAR | ANDA | 13 sections |
AMPICILLIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9816 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAMUSCULAR | ANDA | 13 sections |
AMPICILLIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9817 | INJECTION, POWDER, FOR SOLUTION | 500 mg | INTRAMUSCULAR | ANDA | 13 sections |
AMPICILLIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9818 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 13 sections |
AMPICILLIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9818 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 13 sections |
AMPICILLIN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9818 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 13 sections |
Ampicillin and Sulbactam | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0409-2689 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 25 sections |
Ampicillin and Sulbactam | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0409-2689 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 25 sections |
Ampicillin and Sulbactam | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0409-2987 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 25 sections |
Ampicillin and Sulbactam | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0409-2987 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 25 sections |
Ampicillin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-3718 | INJECTION, POWDER, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 23 sections |
Ampicillin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-3718 | INJECTION, POWDER, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 23 sections |
Ampicillin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-3719 | INJECTION, POWDER, FOR SOLUTION | 250 mg | INTRAVENOUS | ANDA | 23 sections |
Ampicillin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-3719 | INJECTION, POWDER, FOR SOLUTION | 250 mg | INTRAVENOUS | ANDA | 23 sections |
Ampicillin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-3720 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 23 sections |
Ampicillin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-3720 | INJECTION, POWDER, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 23 sections |
Ampicillin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-3725 | INJECTION, POWDER, FOR SOLUTION | 10 g | INTRAVENOUS | ANDA | 22 sections |
Ampicillin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-3726 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 23 sections |
Ampicillin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-3726 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 23 sections |