olprinone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
cardiac stimulants, amrinone derivatives 1987 106730-54-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • E-1020
  • olprinone hydrochloride
  • olprinone hydrochloride hydrate
  • olprinone
  • loprinone
  • olprinone HCl
  • Molecular weight: 250.26
  • Formula: C14H10N4O
  • CLOGP: 0.67
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 70.19
  • ALOGS: -3.45
  • ROTB: 1

Drug dosage:

None

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.64 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 11 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.13 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
April 1, 1996 PMDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D002316 Cardiotonic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D058987 Phosphodiesterase 3 Inhibitors
MeSH PA D010726 Phosphodiesterase Inhibitors
MeSH PA D020011 Protective Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Acute heart failure indication 56675007

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.71 acidic
pKa2 5.31 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Phosphodiesterase 3 Enzyme INHIBITOR DRUG LABEL SCIENTIFIC LITERATURE

External reference:

IDSource
D02042 KEGG_DRUG
119615-63-3 SECONDARY_CAS_RN
C0637063 UMLSCUI
CHEBI:34902 CHEBI
CHEMBL1474900 ChEMBL_ID
7123 INN_ID
C059498 MESH_SUPPLEMENTAL_RECORD_UI
4593 PUBCHEM_CID
4Y8BMI9YGC UNII

Pharmaceutical products:

None